Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnuclear receptor binding

PPARGC1A PRAMEF4 KDM4C PRAMEF11 PRAMEF15

3.12e-06187255GO:0016922
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

3.13e-0682254GO:1990756
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

5.63e-0695254GO:0140767
GeneOntologyMolecularFunctionmolecular adaptor activity

PPARGC1A PRAMEF4 PRAMEF9 CAMTA1 SCIMP KDM4C MIS18A PRAMEF11 PRAMEF15

2.26e-051356259GO:0060090
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF4 PRAMEF11 PRAMEF15

4.36e-0555253GO:0042974
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

PPARGC1A PRAMEF4 PRAMEF9 CAMTA1 KDM4C MIS18A PRAMEF11 PRAMEF15

5.63e-051160258GO:0030674
GeneOntologyMolecularFunctionRNA polymerase II-specific DNA-binding transcription factor binding

PPARGC1A PRAMEF4 KDM4C PRAMEF11 PRAMEF15

1.46e-04417255GO:0061629
GeneOntologyMolecularFunctiontranscription factor binding

PPARGC1A STK36 PRAMEF4 KDM4C PRAMEF11 PRAMEF15

2.70e-04753256GO:0008134
GeneOntologyMolecularFunctionDNA-binding transcription factor binding

PPARGC1A PRAMEF4 KDM4C PRAMEF11 PRAMEF15

6.77e-04582255GO:0140297
GeneOntologyMolecularFunctionnuclear receptor coactivator activity

PPARGC1A KDM4C

2.63e-0361252GO:0030374
GeneOntologyBiologicalProcessblastocyst formation

PRAMEF4 KDM4C PRAMEF11 PRAMEF15

2.66e-0678264GO:0001825
GeneOntologyBiologicalProcessblastocyst development

PRAMEF4 KDM4C PRAMEF11 PRAMEF15

7.06e-05179264GO:0001824
GeneOntologyBiologicalProcessneurotransmitter loading into synaptic vesicle

SLC17A5 SLC18A3

8.35e-0511262GO:0098700
GeneOntologyBiologicalProcessregulation of ERK1 and ERK2 cascade

FGB PRAMEF4 SCIMP PRAMEF11 PRAMEF15

1.05e-04385265GO:0070372
GeneOntologyBiologicalProcessERK1 and ERK2 cascade

FGB PRAMEF4 SCIMP PRAMEF11 PRAMEF15

1.54e-04418265GO:0070371
GeneOntologyBiologicalProcessstem cell population maintenance

PRAMEF4 KDM4C PRAMEF11 PRAMEF15

2.08e-04237264GO:0019827
GeneOntologyBiologicalProcessmaintenance of cell number

PRAMEF4 KDM4C PRAMEF11 PRAMEF15

2.26e-04242264GO:0098727
GeneOntologyBiologicalProcessoocyte development

PRAMEF4 PRAMEF11 PRAMEF15

2.57e-0499263GO:0048599
GeneOntologyBiologicalProcessoocyte differentiation

PRAMEF4 PRAMEF11 PRAMEF15

2.89e-04103263GO:0009994
GeneOntologyBiologicalProcesssomatic stem cell population maintenance

PRAMEF4 PRAMEF11 PRAMEF15

3.32e-04108263GO:0035019
GeneOntologyBiologicalProcessoogenesis

PRAMEF4 PRAMEF11 PRAMEF15

9.71e-04156263GO:0048477
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

2.74e-0747254GO:0031462
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

1.10e-04212254GO:0031461
GeneOntologyCellularComponentubiquitin ligase complex

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

7.56e-04352254GO:0000151
GeneOntologyCellularComponentacrosomal vesicle

PRAMEF4 PRAMEF11 PRAMEF15

1.85e-03206253GO:0001669
GeneOntologyCellularComponentsecretory vesicle

FGB SLC17A5 PRAMEF4 SLC18A3 PRAMEF11 PRAMEF15

2.94e-031246256GO:0099503
MousePhenoabnormal jejunum morphology

PRAMEF4 PRAMEF11 PRAMEF15

2.58e-0541203MP:0004002
MousePhenoabnormal spermatogonia proliferation

PRAMEF4 PRAMEF11 PRAMEF15

3.90e-0547203MP:0002685
MousePhenoincreased kidney weight

PPARGC1A PRAMEF4 PRAMEF11 PRAMEF15

4.73e-05145204MP:0003917
MousePhenoabnormal duodenum morphology

PRAMEF4 PRAMEF11 PRAMEF15

9.87e-0564203MP:0003271
MousePhenoabnormal small intestine morphology

PPARGC1A PRAMEF4 PRAMEF11 PRAMEF15

1.27e-04187204MP:0000496
MousePhenoincreased male germ cell apoptosis

PRAMEF4 TRIM41 PRAMEF11 PRAMEF15

1.32e-04189204MP:0014052
MousePhenoabnormal kidney weight

PPARGC1A PRAMEF4 PRAMEF11 PRAMEF15

1.91e-04208204MP:0002707
MousePhenoabnormal male germ cell apoptosis

PRAMEF4 TRIM41 PRAMEF11 PRAMEF15

3.10e-04236204MP:0008280
MousePhenoabnormal male germ cell physiology

PRAMEF4 TRIM41 PRAMEF11 PRAMEF15

3.52e-04244204MP:0020362
MousePhenoabnormal cecum morphology

PRAMEF4 PRAMEF11 PRAMEF15

3.60e-0499203MP:0000494
MousePhenoabnormal germ cell physiology

PRAMEF4 TRIM41 PRAMEF11 PRAMEF15

4.95e-04267204MP:0020363
MousePhenoenlarged urinary bladder

PRAMEF4 PRAMEF11 PRAMEF15

5.73e-04116203MP:0011874
MousePhenoincreased circulating amylase level

PRAMEF4 PRAMEF11 PRAMEF15

6.17e-04119203MP:0008806
DomainPRAME_family

PRAMEF4 PRAMEF15

2.45e-0419232IPR026271
DomainMFS

SLC17A5 SLC18A3

4.01e-0377232IPR011701
DomainMFS_1

SLC17A5 SLC18A3

4.01e-0377232PF07690
DomainIg_E-set

CPAMD8 CAMTA1

7.20e-03104232IPR014756
DomainMFS

SLC17A5 SLC18A3

7.74e-03108232PS50850
DomainMFS_dom

SLC17A5 SLC18A3

1.17e-02134232IPR020846
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF4 PRAMEF11 PRAMEF15

2.50e-071726323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF4 PRAMEF11 PRAMEF15

2.50e-071726337781892
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF4 PRAMEF11 PRAMEF15

3.00e-071826329731491
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF4 PRAMEF11 PRAMEF15

3.00e-071826323894331
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF4 PRAMEF11 PRAMEF15

3.00e-071826314675769
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF4 PRAMEF11 PRAMEF15

3.00e-071826312890732
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF4 PRAMEF11 PRAMEF15

3.00e-071826339181896
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF4 PRAMEF11 PRAMEF15

3.57e-071926328604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF4 PRAMEF11 PRAMEF15

4.19e-072026316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF4 PRAMEF11 PRAMEF15

4.19e-072026321425410
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF4 PRAMEF11 PRAMEF15

4.19e-072026326694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF4 PRAMEF11 PRAMEF15

5.66e-072226331729367
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF4 PRAMEF11 PRAMEF15

6.50e-072326319480014
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF4 PRAMEF11 PRAMEF15

8.44e-072526337451217
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF4 PRAMEF11 PRAMEF15

8.44e-072526312620990
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF4 PRAMEF11 PRAMEF15

9.53e-072626318500982
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF4 PRAMEF11 PRAMEF15

1.20e-062826325089626
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF4 PRAMEF11 PRAMEF15

1.49e-063026338786026
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF4 PRAMEF11 PRAMEF15

1.81e-063226337889087
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF4 PRAMEF11 PRAMEF15

2.39e-063526319389355
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF4 PRAMEF11 PRAMEF15

5.51e-064626317287250
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF4 PRAMEF11 PRAMEF15

7.10e-065026331806660
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF4 PRAMEF11 PRAMEF15

1.11e-055826331598710
Pubmed

An abundance of X-linked genes expressed in spermatogonia.

PRAMEF4 PRAMEF11 PRAMEF15

1.17e-055926311279525
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

PPARGC1A PRAMEF4 PRAMEF11 PRAMEF15

1.22e-0434726416033648
Pubmed

Transcriptome analysis of mouse stem cells and early embryos.

FRRS1 PRAMEF4 PRAMEF11 PRAMEF15

1.46e-0436326414691545
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

FRRS1 PRAMEF4 SCIMP KDM4C PRAMEF11 PRAMEF15

2.55e-04124226630973865
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

PRAMEF4 KDM4C PRAMEF11 PRAMEF15

2.63e-0442426421731673
InteractionPRAMEF4 interactions

PRAMEF4 PRAMEF9

3.74e-063232int:PRAMEF4
InteractionPRAMEF5 interactions

PRAMEF4 PRAMEF15

3.47e-058232int:PRAMEF5
InteractionPRAMEF9 interactions

PRAMEF4 PRAMEF9

9.64e-0513232int:PRAMEF9
Cytoband1p36.21

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

4.70e-08632641p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF4 PRAMEF9 CAMTA1 PRAMEF11 PRAMEF15

3.60e-05681265chr1p36
CytobandEnsembl 112 genes in cytogenetic band chr2q14

PTPN4 WDR33

3.94e-03165262chr2q14
GeneFamilyPRAME family

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

5.62e-0924174686
CoexpressionKINNEY_DNMT1_METHYLATION_TARGETS

PRAMEF4 PRAMEF11 PRAMEF15

3.96e-0634243MM955
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3_UNMETHYLATED

PRAMEF4 PRAMEF11 PRAMEF15

1.91e-0557243MM1262
CoexpressionKOHOUTEK_CCNT2_TARGETS

PRAMEF4 PRAMEF11 PRAMEF15

5.49e-0581243MM938
CoexpressionMIKKELSEN_NPC_ICP_WITH_H3K4ME3

PPARGC1A FRRS1 PRAMEF4 PRAMEF11 PRAMEF15

7.58e-05497245MM863
CoexpressionDESCARTES_ORGANOGENESIS_SCHWANN_CELL_PRECURSOR

PRAMEF4 PRAMEF11 PRAMEF15

9.69e-0598243MM3656
CoexpressionHUANG_GATA2_TARGETS_DN

PRAMEF4 PRAMEF11 PRAMEF15

9.69e-0598243MM942
CoexpressionMORI_SMALL_PRE_BII_LYMPHOCYTE_UP

PRAMEF4 PRAMEF11 PRAMEF15

9.69e-0598243MM592
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Monophasic_Synovial_Sarcoma-5|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

PRAMEF4 PRAMEF9 PRAMEF11 PRAMEF15

2.47e-07932643e05ea0f8f4a7cdb78a596f47d563dc3c94d4d8e
Diseasecardiovascular system disease (is_implicated_in)

FGB PPARGC1A

9.10e-0521202DOID:1287 (is_implicated_in)
Diseaseresponse to fenofibrate

KDM4C FAM135B

5.24e-0450202GO_1901557
DiseaseHuntington's disease (is_marker_for)

PPARGC1A SLC18A3

5.89e-0453202DOID:12858 (is_marker_for)
Diseasethalamus volume

PPARGC1A CAMTA1

1.51e-0385202EFO_0006935
DiseaseParkinson Disease

FGB PPARGC1A

1.51e-0385202C0030567
Diseasecomplement factor D measurement

PPARGC1A KDM4C

1.80e-0393202EFO_0020283
Diseasemean fractional anisotropy measurement

PPARGC1A CAMTA1

1.88e-0395202EFO_0008399
Diseasepuberty onset measurement

CAMTA1 KDM4C

3.22e-03125202EFO_0005677
Diseasesevere acute respiratory syndrome, COVID-19

PPARGC1A PTPN4 CAMTA1

3.25e-03447203EFO_0000694, MONDO_0100096
Diseasetype 2 diabetes mellitus (is_marker_for)

FGB PPARGC1A

3.79e-03136202DOID:9352 (is_marker_for)
DiseaseCOVID-19, mortality

PPARGC1A KDM4C

5.86e-03170202EFO_0004352, MONDO_0100096
Diseasecoffee consumption measurement

PPARGC1A WDR33

6.68e-03182202EFO_0006781
Diseasevisual perception measurement

CPAMD8 CAMTA1

9.88e-03223202EFO_0009700

Protein segments in the cluster

PeptideGeneStartEntry
ESWMAQWHSEAISSP

CAMTA1

1191

Q9Y6Y1
DFWQMTWEQGSSMVV

PTPN4

736

P29074
MAKHGTDDGVVWMNW

FGB

456

P02675
MDNITWMASHTGWSD

OR2T4

1

Q8NH00
WMASHTGWSDFILMG

OR2T4

6

Q8NH00
CENFWMVWSEAMAHG

PRAMEF15

111

P0DUQ1
GMWKTTFAWHTEDMD

KDM4C

181

Q9H3R0
MAWDMCNQDSESVWS

PPARGC1A

1

Q9UBK2
QMFNWTHWSMGTAAR

FRRS1

476

Q6ZNA5
MRDGVTHWSLSNSWD

CPAMD8

1341

Q8IZJ3
SWMGRGSQEQMESWE

C2orf81

166

A6NN90
DLAWLTSHMMTLWTQ

FAM135B

306

Q49AJ0
GVTFPAMHAMWSSWA

SLC17A5

176

Q9NRA2
NMWDHMQWSKEEEAA

METTL8

46

Q9H825
MISTWMQSNHSCHWA

KRBA2

371

Q6ZNG9
VFWTSGMSRSSWDNM

TRIM41

106

Q8WV44
GMSRSSWDNMDYVWE

TRIM41

111

Q8WV44
TIATWMKHTMAASEW

SLC18A3

311

Q16572
MDTFTVQDSTAMSWW

SCIMP

1

Q6UWF3
DAWLEHTTEMLQMWQ

PNMA3

181

Q9UL41
IMTFNTSLHRSWWME

NKAIN1

96

Q4KMZ8
TASWEQMEWSITGML

SI

606

P14410
DMSSSEMWTVLWHRF

STK36

871

Q9NRP7
CENFWMVWSEAMAHG

PRAMEF4

111

O60810
QKWASMWSSMSEDAS

MIS18A

46

Q9NYP9
CENFWMVWSEAMAHG

PRAMEF9

111

P0DUQ2
CENFWMVWSEAMAHG

PRAMEF11

111

O60813
DSPVRAMTWSHNDMW

WDR33

161

Q9C0J8
AMTWSHNDMWMLTAD

WDR33

166

Q9C0J8