Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaxon guidance receptor activity

EPHB2 EPHB3 EPHB1

7.97e-0613623GO:0008046
GeneOntologyMolecularFunctiontransmembrane-ephrin receptor activity

EPHB2 EPHB3 EPHB1

1.26e-0515623GO:0005005
GeneOntologyMolecularFunctionephrin receptor activity

EPHB2 EPHB3 EPHB1

2.67e-0519623GO:0005003
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK1 GRIK3

1.41e-046622GO:0015277
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

EPHB2 EPHB3 SOSTDC1 EPHB1

1.41e-0485624GO:0019199
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

ABCC9 NIPA2 GRIK1 GRIK3 SLC5A8 CCDC51 SLC30A4

5.78e-04465627GO:0046873
GeneOntologyMolecularFunctionpotassium channel activity

ABCC9 GRIK1 GRIK3 CCDC51

6.74e-04128624GO:0005267
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

EPHB2 EPHB3 GIPR GPR39 TLR2 SOSTDC1 ABCC9 GRIK1 GRIK3 OSMR OR7A17 EPHB1

8.13e-0413536212GO:0004888
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

ABCC9 GRIK1 GRIK3 CCDC51

9.42e-04140624GO:0099094
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

EPHB2 EPHB3 EPHB1

1.09e-0365623GO:0004714
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK1 GRIK3

1.25e-0317622GO:0004970
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK1 GRIK3

1.41e-0318622GO:0015280
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

ABCC9 GRIK1 GRIK3 CCDC51

1.81e-03167624GO:0015079
GeneOntologyMolecularFunctionglucosyltransferase activity

GYS1 GBA2

2.11e-0322622GO:0046527
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK1 GRIK3

2.51e-0324622GO:0099507
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

TMC8 ABCC9 NIPA2 GRIK1 GRIK3 SLC5A8 CCDC51 SLC30A4

3.03e-03793628GO:0015075
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

ABCC9 GRIK1 GRIK3 CCDC51

3.05e-03193624GO:0015276
GeneOntologyMolecularFunctionglutamate receptor activity

GRIK1 GRIK3

3.17e-0327622GO:0008066
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

ABCC9 NIPA2 GRIK1 GRIK3 SLC5A8 CCDC51 SLC30A4

3.21e-03627627GO:0022890
GeneOntologyMolecularFunctionligand-gated channel activity

ABCC9 GRIK1 GRIK3 CCDC51

3.28e-03197624GO:0022834
GeneOntologyMolecularFunctiongated channel activity

TMC8 ABCC9 GRIK1 GRIK3 CCDC51

3.77e-03334625GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

ABCC9 NIPA2 GRIK1 GRIK3 SLC5A8 CCDC51 SLC30A4

4.39e-03664627GO:0008324
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK1 GRIK3

1.37e-046642GO:0032983
GeneOntologyCellularComponentpotassium channel complex

ABCC9 GRIK1 GRIK3 CCDC51

2.92e-04104644GO:0034705
MousePhenoabnormal axon pruning

EPHB2 EPHB3 EPHB1

2.68e-068523MP:0008960
MousePhenoincreased circulating glucose level

KNTC1 GIPR IQSEC3 RAPGEF3 GPR39 GRIK3 BBS5 CEP126 OSMR CCDC51

3.05e-055535210MP:0005559
MousePhenoaortic arch dilation

THSD4 ABCC9

4.06e-053522MP:0010575
DomainRECEPTOR_TYR_KIN_V_2

EPHB2 EPHB3 EPHB1

1.30e-0514633PS00791
DomainRECEPTOR_TYR_KIN_V_1

EPHB2 EPHB3 EPHB1

1.30e-0514633PS00790
DomainEph_TM

EPHB2 EPHB3 EPHB1

1.30e-0514633IPR027936
DomainTyr_kinase_rcpt_V_CS

EPHB2 EPHB3 EPHB1

1.30e-0514633IPR001426
DomainEPH_lbd

EPHB2 EPHB3 EPHB1

1.30e-0514633SM00615
DomainEphrin_lbd

EPHB2 EPHB3 EPHB1

1.30e-0514633PF01404
DomainEphA2_TM

EPHB2 EPHB3 EPHB1

1.30e-0514633PF14575
DomainTyr_kinase_ephrin_rcpt

EPHB2 EPHB3 EPHB1

1.30e-0514633IPR016257
DomainEphrin_rcpt_lig-bd_dom

EPHB2 EPHB3 EPHB1

1.30e-0514633IPR001090
DomainEPH_LBD

EPHB2 EPHB3 EPHB1

1.30e-0514633PS51550
DomainRas_G-nucl-exch_fac_CS

RGL1 RAPGEF3 RGL3

1.30e-0514633IPR019804
Domainfn3

EPHB2 EPHB3 FN1 NFASC OSMR EPHB1

1.75e-05162636PF00041
DomainFN3

EPHB2 EPHB3 FN1 NFASC OSMR EPHB1

3.70e-05185636SM00060
DomainRasGEFN

RGL1 RAPGEF3 RGL3

4.00e-0520633SM00229
DomainSAM/pointed

EPHB2 EPHB3 CNKSR2 TFCP2 EPHB1

4.66e-05117635IPR013761
DomainRasGEF_N

RGL1 RAPGEF3 RGL3

4.66e-0521633PF00618
DomainRas-like_Gua-exchang_fac_N

RGL1 RAPGEF3 RGL3

5.38e-0522633IPR000651
DomainRASGEF_NTER

RGL1 RAPGEF3 RGL3

5.38e-0522633PS50212
DomainFN3

EPHB2 EPHB3 FN1 NFASC OSMR EPHB1

5.56e-05199636PS50853
DomainFN3_dom

EPHB2 EPHB3 FN1 NFASC OSMR EPHB1

7.30e-05209636IPR003961
DomainEphrin_rec_like

EPHB2 EPHB3 EPHB1

7.98e-0525633SM01411
DomainTyr-kin_ephrin_A/B_rcpt-like

EPHB2 EPHB3 EPHB1

7.98e-0525633IPR011641
DomainSAM_1

EPHB2 EPHB3 CNKSR2 EPHB1

8.14e-0568634PF00536
DomainRASGEF

RGL1 RAPGEF3 RGL3

9.00e-0526633PS00720
Domain-

EPHB2 EPHB3 PCSK7 EPHB1

1.07e-04736342.60.120.260
DomainRASGEF_CAT

RGL1 RAPGEF3 RGL3

1.26e-0429633PS50009
DomainRasGEF

RGL1 RAPGEF3 RGL3

1.39e-0430633PF00617
Domain-

RGL1 RAPGEF3 RGL3

1.39e-04306331.10.840.10
DomainRas_GEF_dom

RGL1 RAPGEF3 RGL3

1.39e-0430633IPR023578
DomainRASGEF_cat_dom

RGL1 RAPGEF3 RGL3

1.39e-0430633IPR001895
DomainRasGEF

RGL1 RAPGEF3 RGL3

1.39e-0430633SM00147
DomainSAM

EPHB2 EPHB3 CNKSR2 EPHB1

2.22e-0488634SM00454
DomainGalactose-bd-like

EPHB2 EPHB3 PCSK7 EPHB1

2.86e-0494634IPR008979
DomainSAM_DOMAIN

EPHB2 EPHB3 CNKSR2 EPHB1

2.97e-0495634PS50105
DomainSAM

EPHB2 EPHB3 CNKSR2 EPHB1

3.22e-0497634IPR001660
Domain-

EPHB2 EPHB3 CNKSR2 EPHB1

4.51e-041066341.10.150.50
DomainEphrin_rec_like

EPHB2 EPHB3

6.04e-0411632PF07699
DomainIontro_rcpt

GRIK1 GRIK3

1.65e-0318632IPR001320
DomainLig_chan-Glu_bd

GRIK1 GRIK3

1.65e-0318632PF10613
DomainIono_rcpt_met

GRIK1 GRIK3

1.65e-0318632IPR001508
DomainGlu/Gly-bd

GRIK1 GRIK3

1.65e-0318632IPR019594
DomainLig_chan-Glu_bd

GRIK1 GRIK3

1.65e-0318632SM00918
DomainLig_chan

GRIK1 GRIK3

1.65e-0318632PF00060
DomainPBPe

GRIK1 GRIK3

1.65e-0318632SM00079
Domain-

EPHB2 EPHB3 FN1 TAPBPL MMP23B NFASC OSMR EPHB1

1.67e-036636382.60.40.10
DomainGrowth_fac_rcpt_

EPHB2 EPHB3 MATN2 EPHB1

1.90e-03156634IPR009030
DomainIg-like_fold

EPHB2 EPHB3 FN1 TAPBPL MMP23B NFASC OSMR EPHB1

2.47e-03706638IPR013783
DomainTyrKc

EPHB2 EPHB3 EPHB1

3.27e-0388633SM00219
DomainTyr_kinase_cat_dom

EPHB2 EPHB3 EPHB1

3.27e-0388633IPR020635
PathwayREACTOME_EPHRIN_SIGNALING

EPHB2 EPHB3 EPHB1

2.92e-0518483MM15024
PathwayREACTOME_EPHRIN_SIGNALING

EPHB2 EPHB3 EPHB1

3.46e-0519483M27310
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB2 EPHB3 EPHB1

2.06e-0434483MM15025
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 EPHB3 EPHB1

2.65e-0437483MM15022
PathwayWP_NEURAL_CREST_CELL_MIGRATION_DURING_DEVELOPMENT

EPHB2 EPHB3 EPHB1

3.35e-0440483M39798
PathwayPID_EPHB_FWD_PATHWAY

EPHB2 EPHB3 EPHB1

3.35e-0440483M62
PathwayREACTOME_EPHB_MEDIATED_FORWARD_SIGNALING

EPHB2 EPHB3 EPHB1

3.87e-0442483M27308
PathwayWP_NEURAL_CREST_CELL_MIGRATION_IN_CANCER

EPHB2 EPHB3 EPHB1

4.16e-0443483M39788
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK3

5.02e-0410482M10272
PathwayREACTOME_EPH_EPHRIN_MEDIATED_REPULSION_OF_CELLS

EPHB2 EPHB3 EPHB1

6.88e-0451483M27311
PathwayREACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS

GRIK1 GRIK3

7.33e-0412482MM15142
Pubmed

EphB regulates L1 phosphorylation during retinocollicular mapping.

EPHB2 EPHB3 NFASC EPHB1

3.63e-10764422579729
Pubmed

Multiple EphB receptors mediate dorsal-ventral retinotopic mapping via similar bi-functional responses to ephrin-B1.

EPHB2 EPHB3 EPHB1

5.94e-09364325051176
Pubmed

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.

EPHB2 EPHB3 EPHB1

5.94e-09364314691139
Pubmed

A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development.

EPHB2 EPHB3 EPHB1

5.94e-09364323143520
Pubmed

EphB receptors couple dendritic filopodia motility to synapse formation.

EPHB2 EPHB3 EPHB1

5.94e-09364318614029
Pubmed

Filopodia Conduct Target Selection in Cortical Neurons Using Differences in Signal Kinetics of a Single Kinase.

EPHB2 EPHB3 EPHB1

5.94e-09364329731254
Pubmed

Investigating the effects of compound paralogous EPHB receptor mutations on mouse facial development.

EPHB2 EPHB3 EPHB1

5.94e-09364335025117
Pubmed

A novel feedback mechanism by Ephrin-B1/B2 in T-cell activation involves a concentration-dependent switch from costimulation to inhibition.

EPHB2 EPHB3 EPHB1

5.94e-09364322622783
Pubmed

Retinal axon growth cones respond to EphB extracellular domains as inhibitory axon guidance cues.

EPHB2 EPHB3 EPHB1

5.94e-09364311532925
Pubmed

EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak.

EPHB2 EPHB3 EPHB1

2.37e-08464323147113
Pubmed

Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors.

EPHB2 EPHB3 EPHB1

2.37e-08464322475621
Pubmed

Eph receptor deficiencies lead to altered cochlear function.

EPHB2 EPHB3 EPHB1

2.37e-08464312684184
Pubmed

GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.

EPHB2 EPHB3 EPHB1

2.37e-08464315965473
Pubmed

Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity.

EPHB2 EPHB3 FN1 EPHB1

3.13e-081864418651661
Pubmed

Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping.

EPHB2 EPHB3 EPHB1

5.93e-08564321847105
Pubmed

Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex.

EPHB2 EPHB3 EPHB1

5.93e-08564321559471
Pubmed

EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure.

EPHB2 EPHB3 EPHB1

1.18e-07664326148571
Pubmed

Distribution of EphB receptors and ephrin-B1 in the developing vertebrate spinal cord.

EPHB2 EPHB3 EPHB1

1.18e-07664316786562
Pubmed

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning.

EPHB2 EPHB3 EPHB1

1.18e-07664319182796
Pubmed

Abnormal hippocampal axon bundling in EphB receptor mutant mice.

EPHB2 EPHB3 EPHB1

1.18e-07664315014111
Pubmed

Similarities and Differences in the Way Transmembrane-Type Ligands Interact with the Elk Subclass of Eph Receptors.

EPHB2 EPHB3 EPHB1

2.07e-0776438954633
Pubmed

Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection.

EPHB2 EPHB3 EPHB1

2.07e-07764322103419
Pubmed

Mis-expression of L1 on pre-crossing spinal commissural axons disrupts pathfinding at the ventral midline.

EPHB2 EPHB3 EPHB1

3.31e-07864317884558
Pubmed

Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons.

EPHB2 EPHB3 EPHB1

4.95e-07964310704386
Pubmed

Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.

EPHB2 EPHB3 EPHB1

4.95e-07964311403717
Pubmed

Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion.

EPHB2 EPHB3 EPHB1

4.95e-07964318713744
Pubmed

EphrinB1 modulates glutamatergic inputs into POMC-expressing progenitors and controls glucose homeostasis.

EPHB2 EPHB3 EPHB1

4.95e-07964333253166
Pubmed

EphB/syndecan-2 signaling in dendritic spine morphogenesis.

EPHB2 EPHB3 EPHB1

4.95e-07964311580899
Pubmed

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.

EPHB2 EPHB3 EPHB1

4.95e-07964310683176
Pubmed

Aberrant cell segregation in the craniofacial primordium and the emergence of facial dysmorphology in craniofrontonasal syndrome.

EPHB2 EPHB3 EPHB1

7.07e-071064332092051
Pubmed

EphB signaling regulates target innervation in the developing and deafferented auditory brainstem.

EPHB2 EPHB3 EPHB1

7.07e-071064322021100
Pubmed

Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling.

EPHB2 EPHB3 EPHB1

7.07e-071064325923646
Pubmed

EphB2 guides axons at the midline and is necessary for normal vestibular function.

EPHB2 EPHB3 EPHB1

7.07e-071064310839360
Pubmed

Bidirectional ephrinB3/EphA4 signaling mediates the segregation of medial ganglionic eminence- and preoptic area-derived interneurons in the deep and superficial migratory stream.

EPHB2 EPHB3 EPHB1

9.70e-071164322171039
Pubmed

Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism.

EPHB2 EPHB3 EPHB1

9.70e-071164319515977
Pubmed

Ephrin/ephrin receptor expression during early stages of mouse inner ear development.

EPHB2 EPHB3 EPHB1

1.29e-061264321465626
Pubmed

Retrograde regulation of mossy fiber axon targeting and terminal maturation via postsynaptic Lnx1.

EPHB2 EPHB3 EPHB1

1.68e-061364330185604
Pubmed

EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.

EPHB2 EPHB3 EPHB1

1.68e-061364320616004
Pubmed

Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain.

EPHB2 EPHB3 EPHB1

1.68e-061364316421308
Pubmed

Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord.

EPHB2 EPHB3 EPHB1

2.66e-061564328595615
Pubmed

Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling.

EPHB2 EPHB3 EPHB1

2.66e-061564326839344
Pubmed

Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb.

EPHB2 EPHB3 EPHB1

3.27e-061664319109910
Pubmed

Nolz1 expression is required in dopaminergic axon guidance and striatal innervation.

EPHB2 EPHB3 GRIK3 EPHB1

3.31e-065564432561725
Pubmed

Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.

GRIK1 GRIK3

3.33e-06264219320626
Pubmed

Association of VDR gene polymorphisms and 22 bp deletions in the promoter region of TLR2Δ22 (-196-174) with increased risk of pulmonary tuberculosis: A case-control study in tea garden communities of Assam.

TLR2 VDR

3.33e-06264229727015
Pubmed

EphB2 receptor cell-autonomous forward signaling mediates auditory memory recall and learning-driven spinogenesis.

EPHB2 EPHB1

3.33e-06264231633063
Pubmed

Cell-autonomous role of EphB2 and EphB3 receptors in the thymic epithelial cell organization.

EPHB2 EPHB3

3.33e-06264219731361
Pubmed

Involvement of EphB/Ephrin-B signaling in axonal survival in mouse experimental glaucoma.

EPHB2 EPHB3

3.33e-06264222064993
Pubmed

25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis: A Case-Control Study.

TLR2 VDR

3.33e-06264227124026
Pubmed

EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.

EPHB2 EPHB3

3.33e-06264216777604
Pubmed

Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis.

EPHB2 EPHB3

3.33e-06264238558087
Pubmed

EphB receptors, mainly EphB3, contribute to the proper development of cortical thymic epithelial cells.

EPHB2 EPHB3

3.33e-06264229027839
Pubmed

Null mutations in EphB receptors decrease sharpness of frequency tuning in primary auditory cortex.

EPHB2 EPHB3

3.33e-06264222022561
Pubmed

Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.

EPHB2 EPHB3

3.33e-06264232506584
Pubmed

EphB forward signaling controls directional branch extension and arborization required for dorsal-ventral retinotopic mapping.

EPHB2 EPHB3

3.33e-06264212165470
Pubmed

Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors.

EPHB2 EPHB3

3.33e-06264217122040
Pubmed

The Eph/ephrinB signal balance determines the pattern of T-cell maturation in the thymus.

EPHB2 EPHB3

3.33e-06264221243004
Pubmed

Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.

EPHB2 EPHB3 EPHB1

3.97e-061764312217323
Pubmed

Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm.

EPHB2 EPHB3 EPHB1

3.97e-061764312971893
Pubmed

The role of floor plate contact in the elaboration of contralateral commissural projections within the embryonic mouse spinal cord.

EPHB2 EPHB3 EPHB1

4.75e-061864316854408
Pubmed

Expression of Ephs and ephrins in developing mouse inner ear.

EPHB2 EPHB3 EPHB1

5.64e-061964312684176
Pubmed

Multiple roles of EPH receptors and ephrins in neural development.

EPHB2 EPHB3 EPHB1

6.63e-062064311256076
Pubmed

Eph receptors and ephrins: effectors of morphogenesis.

EPHB2 EPHB3 EPHB1

6.63e-062064310207129
Pubmed

The ephrins and Eph receptors in neural development.

EPHB2 EPHB3 EPHB1

6.63e-06206439530499
Pubmed

The Eph family receptors and ligands.

EPHB2 EPHB3 EPHB1

6.63e-06206439576626
Pubmed

Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee.

EPHB2 EPHB3 EPHB1

7.72e-06216439267020
Pubmed

Roles of Eph receptors and ephrins in segmental patterning.

EPHB2 EPHB3 EPHB1

7.72e-062164311128993
Pubmed

Eph receptors and ephrins demarcate cerebellar lobules before and during their formation.

EPHB2 EPHB3 EPHB1

7.72e-062164310495276
Pubmed

Developmental expression of Eph and ephrin family genes in mammalian small intestine.

EPHB2 EPHB3 EPHB1

7.72e-062164320112066
Pubmed

Eph receptors and ephrins: regulators of guidance and assembly.

EPHB2 EPHB3 EPHB1

7.72e-062164310730216
Pubmed

Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.

EPHB2 EPHB3

9.99e-0636429321682
Pubmed

EphB receptor activity suppresses colorectal cancer progression.

EPHB2 EPHB3

9.99e-06364215973414
Pubmed

Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

EPHB2 EPHB1

9.99e-0636429499402
Pubmed

Completing the structural family portrait of the human EphB tyrosine kinase domains.

EPHB2 EPHB1

9.99e-06364224677421
Pubmed

Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity.

EPHB2 EPHB3

9.99e-06364211754835
Pubmed

Ephrin-B reverse signaling is required for formation of strictly contralateral auditory brainstem pathways.

EPHB2 EPHB3

9.99e-06364220660266
Pubmed

The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain.

GRIK1 GRIK3

9.99e-06364231513786
Pubmed

Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation.

EPHB2 EPHB3

9.99e-06364227810913
Pubmed

EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis.

EPHB2 EPHB1

9.99e-06364218057206
Pubmed

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.

EPHB2 EPHB3

9.99e-06364215223334
Pubmed

Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion.

EPHB2 EPHB3

9.99e-06364234296545
Pubmed

TFCP2c/LSF/LBP-1c is required for Snail1-induced fibronectin gene expression.

FN1 TFCP2

9.99e-06364221361876
Pubmed

Role of genetic variants of Vitamin D receptor, Toll-like receptor 2 and Toll-like receptor 4 in extrapulmonary tuberculosis.

TLR2 VDR

9.99e-06364233991642
Pubmed

Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling.

EPHB2 EPHB3

9.99e-06364220410461
Pubmed

Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier.

FN1 NFASC

9.99e-06364222009740
Pubmed

Kainate receptor-mediated responses in the CA1 field of wild-type and GluR6-deficient mice.

GRIK1 GRIK3

9.99e-0636429880586
Pubmed

EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity.

EPHB2 EPHB1

9.99e-06364215722342
Pubmed

Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.

GRIK1 GRIK3

9.99e-0636427538211
Pubmed

Differential trafficking of GluR7 kainate receptor subunit splice variants.

GRIK1 GRIK3

9.99e-06364215805114
Pubmed

EphrinB1-EphB signaling regulates thymocyte-epithelium interactions involved in functional T cell development.

EPHB2 EPHB1

9.99e-06364217668899
Pubmed

Amygdala EphB2 Signaling Regulates Glutamatergic Neuron Maturation and Innate Fear.

EPHB2 EPHB1

9.99e-06364227683910
Pubmed

Genetic diversity of TLR2, TLR4, and VDR loci and pulmonary tuberculosis in Moroccan patients.

TLR2 VDR

9.99e-06364224727508
Pubmed

ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.

EPHB2 FN1 EPHB1

1.03e-052364326027930
Pubmed

Promotion of proliferation in the developing cerebral cortex by EphA4 forward signaling.

EPHB2 EPHB3 EPHB1

1.03e-052364319542359
Pubmed

Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis.

EPHB2 EPHB3 EPHB1

1.03e-052364319571816
Pubmed

Eph receptors and their ephrin ligands are expressed in developing mouse pancreas.

EPHB2 EPHB3 EPHB1

1.17e-052464316446123
Pubmed

Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling.

EPHB2 EPHB3 EPHB1

1.50e-052664335927240
Pubmed

Eph receptor interclass cooperation is required for the regulation of cell proliferation.

EPHB2 EPHB3

2.00e-05464227565439
Pubmed

RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.

EPHB2 EPHB3

2.00e-05464211956217
Pubmed

Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.

GRIK1 GRIK3

2.00e-05464215513934
Cytoband1p36.3

MMP23B WRAP73

1.72e-04146421p36.3
GeneFamilyFibronectin type III domain containing

EPHB2 EPHB3 FN1 NFASC OSMR EPHB1

2.68e-06160456555
GeneFamilyFibronectin type III domain containing|Sterile alpha motif domain containing|EPH receptors

EPHB2 EPHB3 EPHB1

5.14e-06144531095
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK1 GRIK3

6.03e-0554521199
GeneFamilySterile alpha motif domain containing

EPHB2 EPHB3 CNKSR2 EPHB1

6.70e-0588454760
CoexpressionBROWNE_HCMV_INFECTION_48HR_DN

IQSEC3 FN1 ACACB MATN2 PCSK7 NFASC OSMR ALDH6A1 VDR

2.51e-06482649M12144
ToppCellCTRL-Myeloid-Neutrophil|Myeloid / Disease state, Lineage and Cell class

ZEB1 XPO6 SYNE2 TLR2 MCTP2 EPHB1

1.67e-07170646151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCellCTRL-Myeloid-Neutrophil|CTRL / Disease state, Lineage and Cell class

ZEB1 XPO6 SYNE2 TLR2 MCTP2 EPHB1

1.78e-07172646ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ZEB1 FN1 MATN2 NFASC ABCC9

3.31e-07191646107113b930d9ad171f1b2aa20df4567c94fae7d8
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ZEB1 FN1 MATN2 NFASC ABCC9

3.31e-07191646bc353a79a1d11ca52bba5e3874a80d432e1a7715
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ZEB1 FN1 MATN2 NFASC ABCC9

3.73e-0719564649c99553629cdd83ee56a2e508d5bc8d34b8507b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ZEB1 FN1 MATN2 NFASC ABCC9

3.73e-07195646dd281a249854800f737dc22e0f375f66dfb5cf5f
ToppCellCF-Myeloid-Neutrophil|Myeloid / Disease state, Lineage and Cell class

ZEB1 XPO6 SYNE2 MCTP2 EPHB1

5.32e-061756458020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9 OSMR

5.78e-0617864578a0c6340001a77f5b2d890b6263f574af2e72da
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FN1 MATN2 NFASC ABCC9 STEAP2

6.44e-061826453dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellCF-Myeloid-Neutrophil|CF / Disease state, Lineage and Cell class

ZEB1 XPO6 TLR2 MCTP2 EPHB1

6.62e-06183645da43827952e6fdee2ce94648c316182f272b321c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN8 THSD4 RGL3 TLR2 VDR

6.79e-061846458fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 MATN2 MMP23B SOSTDC1 MCTP2

6.97e-061856456712512100ccef456d2e2bd201d0987986c92ac9
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MYH3 IQSEC3 NFASC GRIK3 MCTP2

7.16e-06186645bdc87e4631a8ea73e262e541aa84a28f24c94b00
ToppCellCF|World / Disease state, Lineage and Cell class

ZEB1 SYNE2 TLR2 MCTP2 EPHB1

7.35e-06187645eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellCOVID-19-kidney-Fibroblast-1|COVID-19 / Disease (COVID-19 only), tissue and cell type

THSD4 MATN2 NFASC ABCC9 OSMR

7.35e-0618764576bfe8c42430a230a8bdf299575c444fb7780f24
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 MATN2 SOSTDC1 CNKSR2 GRIK3

7.54e-06188645921a2c9212a0f2a00fd72c594d80924f27e8b9b7
ToppCelldroplet-Heart-HEART-1m-Neuronal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 MATN2 SOSTDC1 CNKSR2 GRIK3

7.74e-06189645a618a1ddf5097a010c6c2c7341f3a0bd46a29c02
ToppCelldroplet-Heart-HEART-1m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 MATN2 SOSTDC1 CNKSR2 GRIK3

7.74e-061896454e61f9cd1c06bddb47ebf98affc0f97770e26e8c
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIPR IQSEC3 FN1 ABCC9 CCAR2

7.94e-06190645bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIPR IQSEC3 FN1 ABCC9 CCAR2

7.94e-06190645eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 ZEB1 FN1 NFASC ABCC9

7.94e-0619064570c86dd454afb21d4a85db56c5f369d4b342bc97
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9 CNKSR2

8.35e-061926455105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 MATN2 MMP23B NFASC ABCC9

8.56e-06193645dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 MATN2 MMP23B NFASC ABCC9

8.56e-06193645e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9 OSMR

8.78e-0619464590efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9 OSMR

8.78e-06194645df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

GIPR GPR39 RGL3 NFASC MCTP2

8.78e-06194645b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9 OSMR

9.23e-061966452b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 FN1 MATN2 NFASC ABCC9

9.23e-06196645fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CAPN8 KRT15 ASPG SLC5A8 STEAP2

9.23e-06196645a4d05d85fbafa869df19bba3881020ea433d81fb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 FN1 MATN2 NFASC ABCC9

9.23e-06196645802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CAPN8 KRT15 ASPG SLC5A8 STEAP2

9.23e-0619664591a3c3091064f1f5a3bdc1dd5883fc24dce8ff05
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CAPN8 KRT15 ASPG SLC5A8 STEAP2

9.23e-06196645e819088a74d29e958371aa851ac9c74ec55367b7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 FN1 MATN2 NFASC ABCC9

9.23e-061966453a6c942e2907aa07b5e12dbf9019d18f7bfca507
ToppCellBAL-Mild-Epithelial-Epithelial-Basal/Club|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

CAPN8 KRT15 ASPG SLC5A8 STEAP2

9.23e-06196645e675d661b6494ac3a85ba7ee5bdeaa98b8bbe957
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 FN1 MATN2 NFASC ABCC9

9.23e-06196645bba88e91cd3e3a6f5a9b443e3a4da33c5b455e70
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FN1 MATN2 MMP23B NFASC ABCC9

9.46e-061976454cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ORM2 GPR39 GRIK1 CNKSR2 SLC5A8

9.46e-0619764549689a03ab31e53386dbe15c77c09ca3a14ebf4e
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD4 FN1 MATN2 MMP23B SOSTDC1

9.93e-06199645e9820d5fb4e8b46973c4c50ac5db8fb4a1bf603b
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD4 MATN2 MMP23B SOSTDC1 MCTP2

9.93e-0619964538cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

THSD4 MATN2 MMP23B SOSTDC1 MCTP2

1.02e-05200645a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

THSD4 MATN2 MMP23B SOSTDC1 MCTP2

1.02e-0520064509537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellLPS_anti-TNF-Mesenchymal_myocytic|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

THSD4 FN1 MATN2 SOSTDC1 ABCC9

1.02e-0520064567dcbd86fbc79fd585d0793f979e4aac100326c9
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

CAPN8 ZEB1 SYNE2 PCSK7

4.28e-05135644ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCell(08)_PNEC-(2)_48hpi|(08)_PNEC / shred by cell type and Timepoint

THSD4 ZEB1 ASPG CCDC51

5.22e-05142644e95d34170f5053678e0dd9793e68d93c03b05822
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

EPHB3 CAPN8 RGL1 RGL3

6.13e-05148644fd0d8386b94adb1bdc993fbb44d2d87852bfd7f0
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

MYH3 ASPG GRIK3 EPHB1

7.15e-0515464412cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellAT1-AT2_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

ASPG MMP23B ABCC9 SLC5A8

7.33e-05155644010e45ef4b505bf419ea41e4d1619521d1c78319
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Papillary_Adenocarcinoma|TCGA-Lung / Sample_Type by Project: Shred V9

ORM2 ASPG GPR39 ALDH6A1

7.33e-0515564457259549d7ad97d9f628b821417be5ddac7dbff7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9

8.09e-05159644e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

THSD4 MATN2 NFASC ABCC9

8.09e-051596442607b562903228274fbd96168ba826782fab0b53
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|356C / Donor, Lineage, Cell class and subclass (all cells)

THSD4 ORM2 ABCC9 VIRMA

8.09e-0515964424f87c666eff10c1844c900ffd7ad49fa9f80481
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD4 RRN3 TMC8 LRRC70

8.09e-05159644f7bccfeffa737f151417bf52ea45111b0957bce9
ToppCellfacs-Skin-Anagen-24m-Epithelial-bulge_keratinocyte|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 SOSTDC1 VDR EPHB1

9.78e-0516764478909f685ccd1321064eb0887caf9263e0e54879
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

IQSEC3 RAPGEF3 MMP23B MCTP2

1.00e-04168644b4bb03efb601a61465260f93896c56861c588bef
ToppCellmetastatic_Brain-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

GPR39 MMP23B CEP126 EPHB1

1.00e-041686444bf3f85aac4b335efa93d22c9ce7b153cb5ce152
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

IQSEC3 RAPGEF3 MMP23B MCTP2

1.00e-04168644240ea32b64d86f9216785010d6b237d9adf052c9
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

EPHB3 CAPN8 KNTC1 GYS1

1.02e-04169644dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

IQSEC3 RAPGEF3 MMP23B MCTP2

1.02e-04169644e7470a5b060881b2a8ce2ab04b0788396aa13889
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

EPHB2 KNTC1 MATN2 MMP23B

1.02e-04169644335619507857383c3b0b507cdf05d786ed59e585
ToppCellInfluenza_Severe-Neutrophil|World / Disease group and Cell class

XPO6 TLR2 MCTP2 EPHB1

1.02e-041696446e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CAPN8 RRN3 RGL3 PCSK7

1.17e-04175644dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

AP3B2 CCAR2 CNKSR2 ZNF654

1.22e-041776448abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCelldroplet-Limb_Muscle-nan-21m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 THSD4 ASPG GRIK3

1.22e-04177644291231b1520c135e92739e201495fe1935efa927
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ORM2 MATN2 SOSTDC1 GRIK3

1.25e-04178644ef490b45901b2e6dedb519540fa3ae4e4db3a9ba
ToppCell10x3'2.3-week_12-13-Myeloid_macrophage-stroma-erythroid_macrophage|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

THSD4 GPR39 ABCC9 SLC30A4

1.28e-04179644c17ae394b855f01f8ca1765c416fd8b34a96e60b
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 MATN2 MMP23B SOSTDC1

1.28e-0417964402c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCC9 SRBD1 GBA2 TFCP2

1.28e-04179644dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCellP28-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 MATN2 SOSTDC1 CNKSR2

1.31e-041806441e819c5c87704ec6535dfeaae56561895e239d07
ToppCellfacs-Pancreas-Exocrine-24m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT15 FN1 ACACB SOSTDC1

1.31e-0418064472310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCellCOVID-19-Endothelial_cells-Capillary_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

THSD4 ZEB1 SYNE2 SOSTDC1

1.33e-04181644c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCellCOPD-Epithelial-Basal|World / Disease state, Lineage and Cell class

CAPN8 KRT15 GPR39 OSMR

1.33e-041816446d8a886b4afe729f8a05b9c0f4ea9375de735da4
ToppCellRA-07._Pericyte|World / Chamber and Cluster_Paper

FN1 RGL3 NFASC ABCC9

1.36e-041826442075efeae633550fb2eb026d0dfd741c8252482e
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 MATN2 MMP23B ABCC9

1.36e-04182644e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

XPO6 AP3B2 NIPA2 MCTP2

1.36e-04182644d486b0213bd3cf20965cb4e38e95981c4aaff259
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25-31|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MATN2 SOSTDC1 CNKSR2 GRIK3

1.36e-04182644a1c0e4090a9e7aa4941a40c817d178de144888b6
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

CAPN8 THSD4 FN1 GPR39

1.39e-04183644dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 MMP23B SOSTDC1 MCTP2

1.39e-041836447eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

CAPN8 ABCC9 SLC5A8 OSMR

1.39e-041836448e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THSD4 MYH3 FN1 MMP23B

1.39e-04183644b4f29dd3994009bb5eb769d36d95886664e7f87d
ToppCellLV-07._Pericyte|World / Chamber and Cluster_Paper

ZEB1 RGL3 NFASC ABCC9

1.39e-04183644273db6a3b00a93ca852498471187b642b5368185
ToppCellfacs-Brain_Non-Myeloid-Striatum_|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT15 TLR2 SOSTDC1 VDR

1.39e-04183644824ecda1219fb596a01bf5cfeee29a6daa462098
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT15 TLR2 SOSTDC1 VDR

1.39e-0418364482b84ee065fb573688d59da97a327152a1ba294c
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MATN2 SOSTDC1 GRIK3 HAUS2

1.39e-041836448330c39184ce076e1f95fd3725b68af551d89db0
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 FN1 MATN2 MMP23B

1.42e-0418464401257e5c12e38b849fd3d9496c43ded666249ba5
ToppCelldroplet-Lung-1m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACACB ABCC9 CCAR2 OSMR

1.42e-04184644e33e2a887aafba7b6a31f00bb0dbe974b4359fd6
ToppCellfacs-Lung-24m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPHB2 EPHB3 MMP23B ABCC9

1.42e-04184644d754c3de621429b220ae4ac426cdfc619e848462
ToppCellfacs-Skin-nan-24m-Mesenchymal|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL1 FN1 MMP23B ABCC9

1.45e-041856448433a337625ff8398520e223ef92bf9bb0beb14c
ToppCellfacs-Skin-nan-24m-Mesenchymal-fibroblast|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL1 FN1 MMP23B ABCC9

1.45e-04185644049d793d043d5d434f143025de49dd210d18756c
ToppCellfacs-Skin-nan-24m-Mesenchymal-nan|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RGL1 FN1 MMP23B ABCC9

1.45e-0418564463200c42565eea596f9b00728e70e544b8d50a7f
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

THSD4 MATN2 SOSTDC1 MCTP2

1.45e-041856443b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCellnormal-na-Lymphocytic_NK-NK_dim-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

SYNE2 MMP23B PCSK7 MCTP2

1.45e-04185644b1a8a8c4d0fc7605eabc17dcb6bd9e8ab4fd578c
ToppCellLV-07._Pericyte|LV / Chamber and Cluster_Paper

ZEB1 RGL3 NFASC ABCC9

1.45e-04185644acb38eba871ec72f2a8136a33b87d33b8c85465d
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

EPHB2 MATN2 MMP23B SOSTDC1

1.48e-04186644c0a036096c2cb23305605b8aaf18869d6e0fb512
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CAPN8 GPR39 RGL3 TLR2

1.48e-041866442ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCelldroplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 ACACB SYNE2 SOSTDC1

1.48e-041866448eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

ZEB1 FN1 MATN2 EPHB1

1.48e-041866447def03dd856b765bd3f493288641981c4f7fd26e
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

ZEB1 RGL3 NFASC ABCC9

1.48e-04186644c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCellControl-Epithelial-ATII|World / Disease state, Lineage and Cell class

CAPN8 ABCC9 SLC5A8 OSMR

1.48e-04186644f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCelldroplet-Heart-HEART-1m-Neuronal-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPHB2 MATN2 SOSTDC1 GRIK3

1.48e-04186644fddc6b93f98b10aaf8d4ebc142b46d8213f3129d
ComputationalGenes in the cancer module 80.

EPHB2 EPHB3 EPHB1

2.04e-0432393MODULE_80
ComputationalGenes in the cancer module 27.

EPHB2 GPR39 TLR2 GRIK1 GRIK3 VDR EPHB1

2.49e-04355397MODULE_27
ComputationalGenes in the cancer module 51.

EPHB2 EPHB3 EPHB1

2.90e-0436393MODULE_51
Drugbenzo(F)quinoxaline

FN1 GRIK1 GRIK3

1.76e-069643CID000098494
Drugdiazepam

ORM2 ZEB1 GRIK1 GRIK3 BBS5 TFCP2

1.52e-05189646CID000003016
DrugTrimethoprim [738-70-5]; Up 200; 13.8uM; PC3; HT_HG-U133A

EPHB2 THSD4 ANKFY1 RRN3 ALDH6A1 TFCP2

1.81e-051956467377_UP
DrugDydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A

ZEB1 FN1 RAPGEF3 GRIK1 OSMR VDR

1.98e-051986462811_UP
DrugLabetalol hydrochloride [32780-64-6]; Up 200; 11uM; MCF7; HT_HG-U133A

GPR39 TLR2 NFASC GRIK1 OSMR ALDH6A1

2.09e-052006463167_UP
Diseaselow density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

GIPR ACACB RRN3 SYNE2 PCSK7

6.95e-05200635EFO_0004611, EFO_0020945
Diseaseglycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement

SYNE2 GBA2

9.36e-057632EFO_0800551
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

GIPR RRN3 SYNE2 PCSK7

3.03e-04150634EFO_0004611, EFO_0020947
Diseasecardiovascular system disease (is_implicated_in)

GIPR GYS1

9.18e-0421632DOID:1287 (is_implicated_in)
Diseasevitiligo (is_implicated_in)

TLR2 VDR

9.18e-0421632DOID:12306 (is_implicated_in)
DiseaseObesity

ACACB RAPGEF3 BBS5 ALDH6A1

9.78e-04205634C0028754
Diseasetriglycerides:total lipids ratio, high density lipoprotein cholesterol measurement

ACACB RRN3 SYNE2 PCSK7

9.96e-04206634EFO_0004612, EFO_0020947
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

GIPR RRN3 SYNE2 PCSK7

1.31e-03222634EFO_0008317, EFO_0020943
Diseasetriglyceride measurement, very low density lipoprotein cholesterol measurement

ACACB RRN3 SYNE2 PCSK7

1.36e-03224634EFO_0004530, EFO_0008317
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

SYNE2 PCSK7 EPHB1

1.41e-03103633EFO_0008595, EFO_0020944
Diseaseatopic dermatitis (is_implicated_in)

TLR2 VDR

1.41e-0326632DOID:3310 (is_implicated_in)
DiseaseDepressive Symptoms

ABCC9 VDR

1.41e-0326632C0086132
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement

ACACB RRN3 PCSK7

1.53e-03106633EFO_0008317, EFO_0008596
Diseasetuberculosis (is_implicated_in)

TLR2 VDR

1.64e-0328632DOID:399 (is_implicated_in)
Diseasecholesteryl ester measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

ACACB RRN3 PCSK7

1.70e-03110633EFO_0008317, EFO_0008596, EFO_0010351
Diseasefree cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement

ACACB RRN3 PCSK7

1.70e-03110633EFO_0008317, EFO_0008591, EFO_0008596
Diseasechylomicron measurement, total cholesterol measurement, very low density lipoprotein cholesterol measurement

ACACB RRN3 PCSK7

1.70e-03110633EFO_0004574, EFO_0008317, EFO_0008596
Diseaseprostate cancer (is_implicated_in)

TLR2 VDR EPHB1

2.03e-03117633DOID:10283 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
QDRLSNTLQTYIRCR

VDR

356

P11473
SRVVTQNICQYRSLQ

CCAR2

746

Q8N163
RVNVSVGYNCILNIT

BBS5

66

Q8N3I7
SIEYVTQRNCNLTQI

GRIK1

756

P39086
DTIFLREYQTRQNQC

ORM2

76

P19652
QALAACRTAQIVTQY

GIPR

211

P48546
QRQRICVARALYQNT

ABCC9

816

O60706
LNSQVQQTIALRYAC

CAPN8

641

A6NHC0
FQLCTQTRQFYVSIQ

AP3B2

951

Q13367
GTNVTICYVSRNIQN

OSMR

161

Q99650
VYNQQNEDTCIIRIS

RGL1

641

Q9NZL6
INTQSIVQLVQRYRS

ACACB

1106

O00763
LVNVRNCIRFYQTAE

ANKFY1

161

Q9P2R3
NLNTIRTYQVCNVFE

EPHB1

51

P54762
TSVLSRQQVLLRYQQ

ALDH6A1

96

Q02252
VSCFVNFTRLQQITN

HAUS2

41

Q9NVX0
VSSQQFRRVFVQVLC

GPR39

346

O43194
QGYILNSDQTTCRIQ

MATN2

266

O00339
LSERKQITQRYCLQN

MCTP2

486

Q6DN12
ASRNQRILYTVLECQ

ASPG

66

Q86U10
IRTYQVCNVFESSQN

EPHB2

56

P29323
VYLSQRNVASNQVCR

PCSK7

686

Q16549
ARVQTCINLITSQEY

MKNK2

96

Q9HBH9
IVCVSTQINYLNRAL

NIPA2

226

Q8N8Q9
RTYQVCNVRESSQNN

EPHB3

76

P54753
YQNTEEVCQLRTLVN

KNTC1

676

P50748
AETECRYATQLQQIQ

KRT15

351

P19012
RIQQLQRRCQSYTLS

RGL3

461

Q3MIN7
RVVVVTLNTSQYLCQ

HELZ

766

P42694
RRAACTIQTAFRQYQ

IQSEC3

316

Q9UPP2
LRYINITNCVTSSIN

LRRC70

396

Q7Z2Q7
YRITQTNNQLINCRN

MGAT4D

26

A6NG13
RDTQISSRAVYQCNT

NFASC

396

O94856
TVCLRREGQTVYQQV

GBA2

191

Q9HCG7
QRYHQRTNTNVNCPI

FN1

2446

P02751
QAVARQDATLYCTQR

CEP126

896

Q9P2H0
TTIEYVTQRNCNLTQ

GRIK3

741

Q13003
LYSFCQQSRRQRIIQ

GYS1

571

P13807
RSRNAQVAVTQYQVL

RPUSD4

236

Q96CM3
RARQQETQLCLYCSQ

RTL4

271

Q6ZR62
QLVFCYTIIERNNRQ

RRN3

521

Q9NYV6
YICQITTSLYRAQQI

TAPBPL

281

Q9BX59
YQQVSQRAECRTSQL

SYNE2

3766

Q8WXH0
QVNRNTIYSTLVTCV

CCDC51

381

Q96ER9
GTYTCVVRRQQRVLT

MMP23B

366

O75900
QSQVQRYISCKSRFQ

SLC5A8

261

Q8N695
ASRQVYICSNNIQAR

STEAP2

161

Q8NFT2
VQRRESIFCIQYNIR

MYH3

806

P11055
QTQSRVITYAGCITQ

OR7A17

86

O14581
CVQYRLVVRDVNTLQ

WRAP73

26

Q9P2S5
IRINQDYIRTFCSQQ

SRBD1

766

Q8N5C6
TDYSVTRNNVIQLCL

CNKSR2

151

Q8WXI2
EQERSTYVCNKRQQI

RAPGEF3

451

O95398
QQTRAQTACRLLSYL

TMC8

286

Q8IU68
ILRQQIANELNYSCR

WASHC5

956

Q12768
TIYVCQESLQLREQQ

TFCP2

391

Q12800
QCYQLLRTATNVRVI

ZNF654

321

Q8IZM8
QRIQLQCQDGSTRTY

SOSTDC1

141

Q6X4U4
RRNNVTNYNTVVETN

ZEB1

16

P37275
CTIQLQSYRQEVDRT

SLC30A4

406

O14863
SRQICYQSLQESVQV

XPO6

806

Q96QU8
VLCRQVYANRSLTVQ

THSD4

701

Q6ZMP0
NNRITYISNSDLQRC

TLR2

61

O60603
RQQCVEYVTSILQSL

VIRMA

1276

Q69YN4