Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

7.94e-1237978GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-19 ERVK-24

1.00e-1138978GO:0070001
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 HIVEP1 TES TRIM31 CHD3 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ZMAT3 RBSN ZFHX4 ERVK-8 ERVK-5 ERVK-19 RORA ZFR ERVK-24 TRIM37

4.70e-088919719GO:0008270
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

1.68e-0711974GO:0004523
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

5.05e-0714974GO:0003964
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 HIVEP1 TES TRIM31 CHD3 ERVK-7 ERVK-21 ERVK-9 ERVK-10 PPEF1 ZMAT3 RBSN ZFHX4 ERVK-8 ERVK-5 ERVK-19 RORA ZFR ERVK-24 TRIM37

8.99e-0711899720GO:0046914
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 ERVK-7 ERVK-10 ERVK-8

2.94e-0621974GO:0035613
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8

3.06e-0537974GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

3.40e-0538974GO:0034061
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 RHBDL1 ERVK-7 ERVK-21 ERVK-9 ERVK-10 CLCA1 ERVK-8 ERVK-19 ERVK-24

4.58e-054309710GO:0004175
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-7 ERVK-10 ERVK-8

7.30e-0546974GO:0016893
GeneOntologyMolecularFunctionnucleotidyltransferase activity

ERVK-6 PARP3 ERVK-7 ERVK-10 PARP4 ERVK-8

9.85e-05152976GO:0016779
GeneOntologyMolecularFunction(1->3)-beta-D-glucan binding

CLEC4M CD209

1.39e-044972GO:0001872
GeneOntologyMolecularFunctionhistone H3K36 trimethyltransferase activity

SETD2 SETD5

2.31e-045972GO:0140955
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 RHBDL1 ERVK-7 ERVK-21 ERVK-9 ERVK-10 CLCA1 ERVK-8 ERVK-19 ERVK-24 MINDY1

3.31e-046549711GO:0008233
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-7 ERVK-10 ERVK-8

5.95e-0479974GO:0004521
GeneOntologyMolecularFunctionvirion binding

CLEC4M CD209

1.02e-0310972GO:0046790
GeneOntologyMolecularFunctioncadherin binding

TES KTN1 PTPRT PPL HNRNPK GOLGA2 PLIN3

1.33e-03339977GO:0045296
GeneOntologyMolecularFunctionhistone H3K36 methyltransferase activity

SETD2 SETD5

1.76e-0313972GO:0046975
GeneOntologyMolecularFunctiondiacylglycerol-dependent serine/threonine kinase activity

PRKD2 PRKD3

2.68e-0316972GO:0004697
GeneOntologyBiologicalProcessviral process

ERVK-6 TRIM31 SRPK1 ERVK-7 ERVK-21 ERVK-9 ERVK-10 CLEC4M CD209 ERVK-8 ERVK-5 ERVK-19 ERVK-24

3.02e-074649813GO:0016032
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-7 ERVK-10 ERVK-8

3.32e-0713984GO:0015074
GeneOntologyBiologicalProcessDNA biosynthetic process

MYC ERVK-6 PRKD2 PARP3 ERVK-7 ERVK-10 PARP4 ERVK-8

9.53e-06218988GO:0071897
GeneOntologyBiologicalProcessRNA-templated DNA biosynthetic process

ERVK-6 ERVK-7 ERVK-10 PARP4 ERVK-8

4.73e-0583985GO:0006278
GeneOntologyBiologicalProcesscell-cell fusion

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

5.30e-0585985GO:0140253
GeneOntologyBiologicalProcesssyncytium formation by plasma membrane fusion

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

5.30e-0585985GO:0000768
GeneOntologyBiologicalProcesssyncytium formation

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

6.61e-0589985GO:0006949
GeneOntologyBiologicalProcessB cell adhesion

CLEC4M CD209

6.68e-053982GO:0097323
GeneOntologyBiologicalProcesspeptide antigen transport

CLEC4M CD209

6.68e-053982GO:0046968
GeneOntologyBiologicalProcessDNA synthesis involved in DNA repair

ERVK-6 ERVK-7 ERVK-10 ERVK-8

7.94e-0548984GO:0000731
GeneOntologyBiologicalProcessdetection of yeast

CLEC4M CD209

1.33e-044982GO:0001879
GeneOntologyBiologicalProcessendoplasmic reticulum tubular network membrane organization

ATL1 ATL2

1.33e-044982GO:1990809
GeneOntologyBiologicalProcessendoplasmic reticulum tubular network organization

ATL3 ATL1 ATL2

1.50e-0422983GO:0071786
GeneOntologyBiologicalProcessdetection of fungus

CLEC4M CD209

2.21e-045982GO:0016046
GeneOntologyBiologicalProcessDNA recombination

ERVK-6 PARP3 ERVK-7 ERVK-10 SETD2 KLHL15 ERVK-8 KPNA1

3.71e-04368988GO:0006310
GeneOntologyCellularComponentendoplasmic reticulum tubular network membrane

ATL3 ATL1 ATL2

9.92e-075983GO:0098826
DomainGBP_C

ATL3 ATL1 ATL2

1.23e-0510893PF02841
DomainG_GB1_RHD3_dom

ATL3 ATL1 ATL2

1.68e-0511893IPR030386
DomainGuanylate-bd_C

ATL3 ATL1 ATL2

1.68e-0511893IPR003191
DomainGBP

ATL3 ATL1 ATL2

1.68e-0511893PF02263
DomainGuanylate-bd_N

ATL3 ATL1 ATL2

1.68e-0511893IPR015894
DomainG_GB1_RHD3

ATL3 ATL1 ATL2

1.68e-0511893PS51715
DomainBAT2_N

PRRC2C PRRC2B

6.72e-053892PF07001
DomainProtein_Kinase_C_mu-related

PRKD2 PRKD3

6.72e-053892IPR015727
DomainBAT2_N

PRRC2C PRRC2B

6.72e-053892IPR009738
DomainPRRC2

PRRC2C PRRC2B

6.72e-053892IPR033184
Domain-

PARP3 PARP4

1.34e-0448921.20.142.10
DomainPARP_ALPHA_HD

PARP3 PARP4

1.34e-044892PS51060
DomainPoly(ADP-ribose)pol_reg_dom

PARP3 PARP4

1.34e-044892IPR004102
DomainZnf_C2H2_jaz

ZMAT3 PRDM10 ZFR

1.51e-0422893IPR022755
Domainzf-C2H2_jaz

ZMAT3 PRDM10 ZFR

1.51e-0422893PF12171
DomainZnF_U1

ZMAT3 ZFHX4 ZFR

3.49e-0429893SM00451
DomainZnf_U1

ZMAT3 ZFHX4 ZFR

3.49e-0429893IPR003604
DomainZnf_C2H2-like

SP2 SP3 HIVEP1 ZNF518A HINFP ZMAT3 RBSN PRDM10 ZFHX4 ZNF335 ZFR ZNF292

3.85e-047968912IPR015880
DomainZnF_C2H2

SP2 SP3 HIVEP1 ZNF518A HINFP ZMAT3 RBSN PRDM10 ZFHX4 ZNF335 ZFR ZNF292

4.40e-048088912SM00355
DomainRFX_DNA_binding

RFX8 RFX1

7.91e-049892PF02257
DomainDNA-bd_RFX

RFX8 RFX1

7.91e-049892IPR003150
DomainRFX_DBD

RFX8 RFX1

7.91e-049892PS51526
DomainSp1_fam

SP2 SP3

9.86e-0410892IPR030450
DomainBTB-kelch_protein

KLHL7 KLHL15 KLHL18

1.12e-0343893IPR017096
DomainZINC_FINGER_C2H2_1

SP2 SP3 HIVEP1 ZNF518A HINFP RBSN PRDM10 ZFHX4 ZNF335 ZFR ZNF292

1.14e-037778911PS00028
DomainZnf_C2H2

SP2 SP3 HIVEP1 ZNF518A HINFP RBSN PRDM10 ZFHX4 ZNF335 ZFR ZNF292

1.52e-038058911IPR007087
DomainSET_dom

SETD2 PRDM10 SETD5

1.74e-0350893IPR001214
DomainSET

SETD2 PRDM10 SETD5

1.74e-0350893PS50280
DomainKelch

KLHL7 KLHL15 KLHL18

2.67e-0358893SM00612
DomainPoly(ADP-ribose)pol_cat_dom

PARP3 PARP4

2.91e-0317892IPR012317
DomainPARP_CATALYTIC

PARP3 PARP4

2.91e-0317892PS51059
DomainPARP

PARP3 PARP4

2.91e-0317892PF00644
Domain-

PARP3 PARP4

2.91e-03178923.90.228.10
DomainBACK

KLHL7 KLHL15 KLHL18

2.94e-0360893SM00875
DomainBACK

KLHL7 KLHL15 KLHL18

3.08e-0361893PF07707
DomainBACK

KLHL7 KLHL15 KLHL18

3.08e-0361893IPR011705
DomainZINC_FINGER_C2H2_2

SP2 SP3 HIVEP1 ZNF518A HINFP RBSN PRDM10 ZFHX4 ZNF335 ZNF292

3.77e-037758910PS50157
DomainDAG/PE-bd

PRKD2 PRKD3

4.45e-0321892IPR020454
DomainKelch_1

KLHL7 KLHL15 KLHL18

4.55e-0370893PF01344
DomainKelch_1

KLHL7 KLHL15 KLHL18

4.55e-0370893IPR006652
DomainG_patch

ERVK-6 AGGF1

5.32e-0323892SM00443
DomainG_patch_dom

ERVK-6 AGGF1

5.32e-0323892IPR000467
DomainG_PATCH

ERVK-6 AGGF1

5.32e-0323892PS50174
DomainG-patch

ERVK-6 AGGF1

5.32e-0323892PF01585
Domainzf-CCHC

ERVK-6 ERVK-5

5.32e-0323892PF00098
Domain-

LNX2 TRIM31 RNF213 CHD3 RBSN ZFYVE9 TRIM37

5.62e-034498973.30.40.10
Domainzf-C2H2

SP2 SP3 HIVEP1 ZNF518A HINFP PRDM10 ZFHX4 ZNF335 ZNF292

5.72e-03693899PF00096
DomainZnf_C2H2/integrase_DNA-bd

SP2 SP3 HIVEP1 ZNF518A HINFP PRDM10 ZFHX4 ZNF335 ZNF292

5.77e-03694899IPR013087
DomainWGR_domain

PARP3 PARP4

5.79e-0324892IPR008893
DomainZnf_RING/FYVE/PHD

LNX2 TRIM31 RNF213 CHD3 RBSN ZFYVE9 TRIM37

6.31e-03459897IPR013083
DomainFHA

KIF16B AGGF1

7.83e-0328892SM00240
DomainFYVE

RBSN ZFYVE9

8.38e-0329892PF01363
DomainFYVE

RBSN ZFYVE9

8.38e-0329892SM00064
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-7 ERVK-21 ERVK-9 ERVK-10 ERVK-8 ERVK-5 ERVK-19 ERVK-24

7.37e-129499921542922
Pubmed

Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.

ERVK-6 ERVK-7 ERVK-10 ERVK-24

6.18e-11499410469592
Pubmed

Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.

ERVK-6 ERVK-10 ERVK-5 ERVK-19

6.18e-1149947983737
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-21 ERVK-9 ERVK-8 ERVK-19

1.32e-101299514557543
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-7 ERVK-21 ERVK-19

3.08e-10599412629516
Pubmed

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes.

ATL3 ATL1 ATL2

2.24e-08399325773277
Pubmed

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.

ATL3 ATL1 ATL2

2.24e-08399327669642
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TES KTN1 RFX1 HNRNPK SETD2 PRRC2C ZFR QSER1 AMOTL2 SNRNP200 PLIN3 PRRC2B

5.65e-08549991238280479
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

MYC SP2 SP3 HIVEP1 TES MBNL1 CHD3 RFX1 HINFP ZMAT3 TSC22D1 RORA ZFR ZNF292

7.32e-08808991420412781
Pubmed

Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.

ERVK-21 ERVK-9 ERVK-10 ERVK-24

1.83e-071899418664271
Pubmed

Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.

ERVK-6 ERVK-7 ERVK-5

2.23e-07599311401426
Pubmed

Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network.

ATL3 ATL1 ATL2

2.23e-07599327619977
Pubmed

Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.

ERVK-6 ERVK-9 ERVK-19

4.45e-07699315063128
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

KNTC1 HIVEP1 MBNL1 CHD3 RFX1 HNRNPK LENG8 PRRC2C ZFR QSER1 SNRNP200 PLIN3 PRRC2B RAI1 ZNF292

5.37e-071103991534189442
Pubmed

A class of dynamin-like GTPases involved in the generation of the tubular ER network.

ATL3 ATL1 ATL2

7.77e-07799319665976
Pubmed

Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.

ATL3 ATL1 ATL2

7.77e-07799323969831
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

MBNL1 KIF16B PPL HNRNPK GOLGA2 FCHSD1

8.12e-0711199622558309
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

MYC PLEKHG4 KTN1 AGGF1 RFX1 PRDM10 ZFHX4 PRRC2C UTP20 ZFR QSER1 SNRNP200 KPNA1

9.92e-07857991325609649
Pubmed

A human MAP kinase interactome.

MYC CASP8AP2 HIVEP1 KTN1 HNRNPK LENG8 TSC22D1 SNRNP200 GOLGA2 WNK2

1.33e-06486991020936779
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

HIVEP1 PLEKHG4 PPL HNRNPK LENG8 SETD2 RORA TRIM37 WNK2 PRRC2B KPNA1

1.34e-06608991116713569
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KNTC1 SP2 MAN2B2 KTN1 RNF213 PARP4 TSC22D1 SETD2 SNRNP200 KLHL18

1.51e-06493991015368895
Pubmed

The E3 Ubiquitin Ligase SYVN1 Ubiquitinates Atlastins to Remodel the Endoplasmic Reticulum Network.

ATL3 ATL1 ATL2

1.86e-06999332916628
Pubmed

Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.

ERVK-6 ERVK-21 ERVK-19

2.65e-061099312970426
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HIVEP1 KTN1 MBNL1 CHD3 RFX1 HNRNPK LENG8 SETD2 PRRC2C ZFR QSER1 SNRNP200 RAI1

3.22e-06954991336373674
Pubmed

Lymph Node Mesenchymal and Endothelial Stromal Cells Cooperate via the RANK-RANKL Cytokine Axis to Shape the Sinusoidal Macrophage Niche.

CLEC4M CD209 CLCA1

4.83e-061299331201093
Pubmed

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

CHD3 SETD2 GCC2 AMOTL2

5.22e-064099428805822
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

PRKD2 HIVEP1 KTN1 AGGF1 PRKD3 GCC2 KLHL15 COPS7B ZFR SNRNP200 KLHL18 PRRC2B KPNA1

5.65e-061005991319615732
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

MYC SP2 SP3 HIVEP1 TES MBNL1 AGGF1 RBSN RORA ZFR ZNF292

5.80e-06709991122988430
Pubmed

Functional proteomics mapping of a human signaling pathway.

PRKD2 HIVEP1 CHD3 RFX1 PPL ZNF518A MTMR11 ZFYVE9 PLIN3 KPNA1

7.48e-06591991015231748
Pubmed

Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.

CLEC4M CD209

8.02e-06299212351402
Pubmed

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs.

CLEC4M CD209

8.02e-06299225870292
Pubmed

The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection.

CLEC4M CD209

8.02e-06299218981244
Pubmed

Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration.

PRKD2 PRKD3

8.02e-06299224840177
Pubmed

[Genetic polymorphism of dendritic cell-specific ICAM-3 grabbing nonintegrin and DC-SIGNR's exon 4 in Chinese hepatitis C patients].

CLEC4M CD209

8.02e-06299218171520
Pubmed

Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299212502850
Pubmed

Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299212137941
Pubmed

A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands.

CLEC4M CD209

8.02e-06299211384997
Pubmed

Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN.

CLEC4M CD209

8.02e-06299211581396
Pubmed

DC-SIGN and L-SIGN: the SIGNs for infection.

CLEC4M CD209

8.02e-06299218458800
Pubmed

Protein kinase Ds promote tumor angiogenesis through mast cell recruitment and expression of angiogenic factors in prostate cancer microenvironment.

PRKD2 PRKD3

8.02e-06299230841931
Pubmed

Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299212634366
Pubmed

The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmission.

CLEC4M CD209

8.02e-06299220217198
Pubmed

Setd5, but not Setd2, is indispensable for retinal cell survival and proliferation.

SETD2 SETD5

8.02e-06299236349512
Pubmed

Extended neck regions stabilize tetramers of the receptors DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299215509576
Pubmed

SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen.

CLEC4M CD209

8.02e-06299223238564
Pubmed

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation.

MYC HNRNPK

8.02e-06299216293596
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

8.02e-0629929060628
Pubmed

Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus.

ATL1 ATL2

8.02e-06299234817557
Pubmed

Role of homozygous DC-SIGNR 5/5 tandem repeat polymorphism in HIV-1 exposed seronegative North Indian individuals.

CLEC4M CD209

8.02e-06299217876530
Pubmed

Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection.

CLEC4M CD209

8.02e-06299216134084
Pubmed

Polymorphisms in DC-SIGN and L-SIGN genes are associated with HIV-1 vertical transmission in a Northeastern Brazilian population.

CLEC4M CD209

8.02e-06299222902397
Pubmed

C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.

CLEC4M CD209

8.02e-06299212050398
Pubmed

The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?

CLEC4M CD209

8.02e-06299212223058
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

8.02e-0629929460924
Pubmed

SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice.

CLEC4M CD209

8.02e-06299226079881
Pubmed

[Analysis of DC-SIGN and DC-SIGNR genetic polymorphism in Chinese Han population].

CLEC4M CD209

8.02e-06299216883544
Pubmed

The clinical significance of DC-SIGN and DC-SIGNR, which are novel markers expressed in human colon cancer.

CLEC4M CD209

8.02e-06299225504222
Pubmed

Utilization of human DC-SIGN and L-SIGN for entry and infection of host cells by the New World arenavirus, Junín virus.

CLEC4M CD209

8.02e-06299224183720
Pubmed

High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin.

CLEC4M CD209

8.02e-06299215136555
Pubmed

SIGN-R1 contributes to protection against lethal pneumococcal infection in mice.

CLEC4M CD209

8.02e-06299215583012
Pubmed

Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens.

CLEC4M CD209

8.02e-06299215184372
Pubmed

Murine SIGNR1 (CD209b) Contributes to the Clearance of Uropathogenic Escherichia coli During Urinary Tract Infections.

CLEC4M CD209

8.02e-06299231998663
Pubmed

Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes.

CLEC4M CD209

8.02e-06299215111305
Pubmed

Atlastin GTPases are required for Golgi apparatus and ER morphogenesis.

ATL3 ATL2

8.02e-06299218270207
Pubmed

Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses.

CLEC4M CD209

8.02e-06299216365436
Pubmed

Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population.

CLEC4M CD209

8.02e-06299224874302
Pubmed

Human lectins and their roles in viral infections.

CLEC4M CD209

8.02e-06299225642836
Pubmed

Structural basis for selective recognition of oligosaccharides by DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299211739956
Pubmed

C-type lectin receptor SIGNR1 expressed on peritoneal phagocytic cells with an immature dendritic cell-like phenotype is involved in uptake of oligomannose-coated liposomes and subsequent cell maturation.

CLEC4M CD209

8.02e-06299224491912
Pubmed

Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.

PRKD2 PRKD3

8.02e-06299225802335
Pubmed

L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.

CLEC4M CD209

8.02e-06299215371595
Pubmed

Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor's role as an antigen-capturing rather than an adhesion receptor.

CLEC4M CD209

8.02e-06299215795245
Pubmed

Autonomous tetramerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299219249311
Pubmed

N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.

CLEC4M CD209

8.02e-06299221191006
Pubmed

Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis.

CLEC4M CD209

8.02e-06299217224292
Pubmed

Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression.

MYC HNRNPK

8.02e-06299226317903
Pubmed

Oligomerization domains in the glycan-binding receptors DC-SIGN and DC-SIGNR: Sequence variation and stability differences.

CLEC4M CD209

8.02e-06299227859859
Pubmed

Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins.

CLEC4M CD209

8.02e-06299216682406
Pubmed

Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells.

PRKD2 PRKD3

8.02e-06299223393329
Pubmed

DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans.

CLEC4M CD209

8.02e-06299227334579
Pubmed

Difference in fine specificity to polysaccharides of Candida albicans mannoprotein between mouse SIGNR1 and human DC-SIGN.

CLEC4M CD209

8.02e-06299222331432
Pubmed

DC-SIGN and DC-SIGNR polymorphic variants in Northern Asian Indians.

CLEC4M CD209

8.02e-06299219046307
Pubmed

Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran.

CLEC4M CD209

8.02e-06299227309478
Pubmed

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein gp120.

CLEC4M CD209

8.02e-0629921518869
Pubmed

Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule.

CLEC4M CD209

8.02e-06299224434373
Pubmed

DC-SIGN, DC-SIGNR and LSECtin: C-type lectins for infection.

CLEC4M CD209

8.02e-06299224156700
Pubmed

Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors.

CLEC4M CD209

8.02e-06299235380569
Pubmed

DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2.

CLEC4M CD209

8.02e-06299212609975
Pubmed

CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.

CLEC4M CD209

8.02e-06299215496474
Pubmed

Protein kinase D3 conditional knockout impairs osteoclast formation and increases trabecular bone volume in male mice.

PRKD2 PRKD3

8.02e-06299237044359
Pubmed

Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression.

SP2 SP3

8.02e-0629921341900
Pubmed

Interaction of acute lymphopblastic leukemia cells with C-type lectins DC-SIGN and L-SIGN.

CLEC4M CD209

8.02e-06299218375037
Pubmed

Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins down regulate both DC-SIGN and DC-SIGNR.

CLEC4M CD209

8.02e-06299223460925
Pubmed

Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion.

CLEC4M CD209

8.02e-06299226447454
Pubmed

[Relationship between intrauterine infection and the gene polymorphism of DC-SIGN/DC-SIGNR in the pregnant women of HBV positive].

CLEC4M CD209

8.02e-06299222338216
Pubmed

DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility.

CLEC4M CD209

8.02e-06299217509452
Pubmed

HIV-1 transmission by dendritic cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) is regulated by determinants in the carbohydrate recognition domain that are absent in liver/lymph node-SIGN (L-SIGN).

CLEC4M CD209

8.02e-06299219833723
Pubmed

[Natural selection of DC-SIGN and its homologues L-SIGN and mSIGNR1 in pathogen recognition and innate immunity].

CLEC4M CD209

8.02e-06299216386217
Pubmed

The polymorphisms in DC-SIGNR affect susceptibility to HIV type 1 infection.

CLEC4M CD209

8.02e-06299217530994
Pubmed

Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry.

CLEC4M CD209

8.02e-06299217715238
InteractionFHL2 interactions

MYC SP2 SP3 TES MBNL1 RIBC1 RFX1 ZFYVE9 PRRC2C ZFR QSER1 TRIM37

3.14e-073969412int:FHL2
InteractionSP7 interactions

MYC HIVEP1 MBNL1 CHD3 RFX1 LENG8 ZFHX4 ZFR QSER1 PRRC2B

1.56e-063049410int:SP7
InteractionSNX33 interactions

MYC PRKD2 HNRNPK PRKD3 FCHSD1

1.22e-0564945int:SNX33
InteractionC2CD3 interactions

CEP162 CEP128 HNRNPK TRIM37

1.85e-0534944int:C2CD3
InteractionSUPT5H interactions

MYC HIVEP1 CHD3 HNRNPK LENG8 ZFYVE9 SETD5 ATL2 SNRNP200 GOLGA2

2.06e-054089410int:SUPT5H
InteractionDHX40 interactions

MYC KTN1 LENG8 SETD2 UTP20 SNRNP200 RAI1 KPNA1

2.16e-05249948int:DHX40
InteractionFCRL5 interactions

MYC CAGE1 AMOTL2

2.72e-0513943int:FCRL5
InteractionTACR3 interactions

PRKD2 KTN1 ATL3 LENG8 ATL2

2.82e-0576945int:TACR3
InteractionAKAP8 interactions

MYC TES TRIM31 CHD3 PPEF1 HNRNPK TRIM37

3.36e-05193947int:AKAP8
InteractionKRT6B interactions

MYC KRT32 CHD3 WTAP TRIM37 GOLGA2

3.58e-05132946int:KRT6B
InteractionFBL interactions

MYC KTN1 TRIM31 SRPK1 CHD3 LENG8 PRRC2C UTP20 ZFR TRIM37 PRRC2B KPNA1

4.14e-056399412int:FBL
InteractionFEV interactions

SP2 HIVEP1 RFX1 LENG8 ZFHX4 QSER1 PRRC2B

4.63e-05203947int:FEV
InteractionKRT78 interactions

MYC KRT32 CHD3 WTAP QSER1

5.42e-0587945int:KRT78
InteractionCEBPA interactions

MYC KNTC1 HIVEP1 MBNL1 CHD3 RFX1 WTAP HNRNPK LENG8 PRRC2C ZFR QSER1 SNRNP200 PLIN3 PRRC2B RAI1 ZNF292

5.66e-0512459417int:CEBPA
InteractionCECR2 interactions

MYC SETD2 PRRC2B KPNA1

6.23e-0546944int:CECR2
InteractionRGL1 interactions

ATL3 LENG8 ATL2

7.62e-0518943int:RGL1
InteractionSNRPA interactions

MYC MBNL1 TRIM31 SRPK1 HNRNPK LENG8 SETD2 PRRC2C ZFR SNRNP200

8.38e-054829410int:SNRPA
InteractionALB interactions

MYC PRKD2 MBNL1 TRIM31 CHD3 WTAP TSC22D1 TRIM37 ZNF292

8.84e-05391949int:ALB
InteractionSF1 interactions

MYC TES TRIM31 HNRNPK ZFR SNRNP200 PRRC2B KPNA1

8.85e-05304948int:SF1
InteractionDCLRE1A interactions

KTN1 TRIM37 KPNA1

1.06e-0420943int:DCLRE1A
InteractionNAGK interactions

LNX2 TES MBNL1 SETD5 PRRC2B RAI1

1.12e-04162946int:NAGK
InteractionDZIP1L interactions

PRKD2 AMOTL2 TRIM37

1.23e-0421943int:DZIP1L
InteractionKRT1 interactions

MYC TRIM31 CHD3 WTAP AMOTL2 TRIM37 GOLGA2

1.25e-04238947int:KRT1
InteractionSNRPB interactions

MYC KNTC1 SP3 SRPK1 CHD3 HNRNPK SETD2 ZFR SNRNP200 GOLGA2

1.49e-045179410int:SNRPB
InteractionSEC16A interactions

MYC TES TRIM31 PPEF1 HNRNPK PRRC2C TRIM37 GOLGA2 PRRC2B

1.69e-04426949int:SEC16A
InteractionCPSF6 interactions

MYC TRIM31 SRPK1 WTAP HNRNPK LENG8 SETD2 ZFR SNRNP200 TRIM37

1.71e-045269410int:CPSF6
InteractionTSSC4 interactions

MYC ATL3 SNRNP200 GOLGA2 KPNA1

1.72e-04111945int:TSSC4
InteractionFXR2 interactions

MYC HIVEP1 TRIM31 CHD3 PRRC2C AMOTL2 TRIM37 GOLGA2 PRRC2B

1.81e-04430949int:FXR2
InteractionSNRNP40 interactions

MYC CASP8AP2 HIVEP1 MBNL1 AGGF1 SRPK1 CHD3 LENG8 SETD2 PRDM10 SNRNP200

1.85e-046379411int:SNRNP40
InteractionHMGXB4 interactions

MYC CHD3 LENG8 TSC22D1 KPNA1

1.87e-04113945int:HMGXB4
InteractionNUP50 interactions

MYC RFX1 TSC22D1 KLHL7 ZFR RAI1 ZNF292 KPNA1

1.95e-04341948int:NUP50
InteractionUGT2B10 interactions

MYC PRKD2

2.13e-045942int:UGT2B10
InteractionEEF1A1 interactions

MYC PRKD2 CEP162 CAGE1 CHD3 WTAP HNRNPK PRRC2C GCC2 SNRNP200 TRIM37 PLIN3

2.18e-047629412int:EEF1A1
InteractionCINP interactions

MYC SP2 AMOTL2 GOLGA2

2.28e-0464944int:CINP
InteractionAPOBEC3C interactions

MYC SRPK1 CHD3 HNRNPK LENG8 ZFR

2.44e-04187946int:APOBEC3C
InteractionTSC22D4 interactions

PRKD2 PPL TSC22D1 GOLGA2 WNK2

2.48e-04120945int:TSC22D4
InteractionTERF2IP interactions

MYC HIVEP1 CHD3 RFX1 WTAP HNRNPK SETD2 QSER1 RAI1 ZNF292

2.52e-045529410int:TERF2IP
InteractionCOIL interactions

MYC CASP8AP2 HIVEP1 PLEKHG4 AGGF1 CHD3 UTP20 SNRNP200 ZNF292 KPNA1

2.52e-045529410int:COIL
InteractionBCAS2 interactions

MYC MBNL1 CHD3 GCC2 SNRNP200 GOLGA2 PRRC2B

2.72e-04270947int:BCAS2
InteractionPALLD interactions

MYC TES CEP162 CEP128 TRIM37

2.78e-04123945int:PALLD
InteractionSOX2 interactions

SP2 HIVEP1 SRPK1 CHD3 RFX1 PPL HNRNPK PARP4 SETD2 ZFHX4 CROCC2 ZFR QSER1 AMOTL2 RSPH10B PRRC2B ZNF292

2.82e-0414229417int:SOX2
InteractionIKBKG interactions

MYC LNX2 TES TRIM31 SRPK1 PRKD3 LENG8 TRIM37 KPNA1

2.88e-04458949int:IKBKG
InteractionKRT5 interactions

MYC KRT32 TRIM31 CHD3 WTAP TRIM37

2.89e-04193946int:KRT5
Cytoband7p22.1

ERVK-6 RSPH10B2 RSPH10B

1.43e-04479837p22.1
Cytoband6q14.3

CEP162 ZNF292

6.75e-04189826q14.3
Cytoband19p13

CLEC4M CD209

1.53e-032798219p13
Cytoband14q22.1

KTN1 ATL1

1.89e-033098214q22.1
GeneFamilyRegulatory factor X family

RFX8 RFX1

2.70e-0485721153
GeneFamilyKelch like|BTB domain containing

KLHL7 KLHL15 KLHL18

3.13e-0442573617
GeneFamilyZinc fingers C2H2-type|Sp transcription factors

SP2 SP3

3.47e-049572755
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP3 PARP4

1.29e-0317572684
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

SP2 SP3 HIVEP1 ZNF518A HINFP PRDM10 ZNF335 ZNF292

1.76e-0371857828
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PRKD2 PLEKHG4 VEPH1 PRKD3

4.04e-03206574682
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

RBSN ZFYVE9

4.28e-033157281
CoexpressionKOINUMA_TARGETS_OF_SMAD2_OR_SMAD3

MYC LNX2 TES MBNL1 AGGF1 CHD3 HNRNPK PARP4 TSC22D1 PRDM10 MTMR11 ZNF335 AMOTL2 KPNA1

1.07e-068439014M2356
CoexpressionGSE24671_CTRL_VS_SENDAI_VIRUS_INFECTED_MOUSE_SPLENOCYTES_DN

SLC9A9 CHD3 RFX1 PRRC2C PRRC2B RAI1 ZNF292

5.74e-06199907M9443
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

KNTC1 SLC9A9 SETD2 PRDM10 PRRC2C KLHL18

3.73e-05180906M8239
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

PRKD2 SP3 KTN1 MBNL1 AGGF1 RNF213 CHD3 PRKD3 ZMAT3 SETD2 SETD5 RORA ZFR SNRNP200 PRRC2B ZNF292

4.41e-0514929016M40023
CoexpressionGSE30971_WBP7_HET_VS_KO_MACROPHAGE_DN

KTN1 ATL3 LDLRAD3 WTAP ZFR GOLGA2

6.51e-05199906M8721
CoexpressionGSE339_CD8POS_VS_CD4CD8DN_DC_IN_CULTURE_DN

PRKD2 PRKD3 KLHL7 RORA ZNF292 KPNA1

6.69e-05200906M5128
CoexpressionGSE46606_DAY1_VS_DAY3_CD40L_IL2_IL5_STIMULATED_IRF4HIGH_BCELL_UP

HNRNPK TSC22D1 SETD5 BBS12 TRIM37 PLIN3

6.69e-05200906M9838
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MBNL1 RNF213 CHD3 PRRC2C GCC2 RORA SNRNP200 ZNF292

6.68e-0919790857ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellhuman_hepatoblastoma|World / Sample and Cell Type and Tumor Cluster (all cells)

DCDC2 HIVEP1 MBNL1 SETD5 PRRC2C GCC2 ZNF292

1.33e-07193907e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 KLHL15 ATL2 BBS12 WNK2 PRRC2B

1.41e-061739068bffd512a4e561e23cc04478e2ca6fd5d3771fe4
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-immature_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 KLHL15 ATL2 BBS12 WNK2 PRRC2B

1.41e-061739063e3c61468e703330788a10d850ef41a85680f86d
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

CASP8AP2 SP3 KIF16B PARP4 PRDM10 GCC2

2.15e-0618690603db813598b67b1e08f759758a1c2023396921fa
ToppCell3'-Adult-Distal_Rectal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KTN1 MBNL1 TRIM31 MTMR11 PRRC2C GCC2

3.08e-061989067ad7726fc405806b1d7824f58548073ea5e0c70b
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell-TA|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KTN1 MBNL1 TRIM31 MTMR11 PRRC2C GCC2

3.08e-061989061fbec311f2c987ca90a023a5989128c05aa12d5c
ToppCell3'-Adult-Distal_Rectal-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KTN1 MBNL1 TRIM31 MTMR11 PRRC2C GCC2

3.08e-06198906ceede961ad9af6a3159db7efaa5087bf38aafc2d
ToppCell3'-Adult-Distal_Rectal-Epithelial-epithelial_progenitor_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KTN1 MBNL1 TRIM31 MTMR11 PRRC2C GCC2

3.08e-061989064f26a60e99f42343e5af7221723e108a1a1b7827
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 KTN1 MBNL1 WTAP PRRC2C

2.68e-05173905869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 KTN1 MBNL1 WTAP PRRC2C

2.68e-051739050672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SP3 KTN1 MBNL1 WTAP PRRC2C

2.68e-05173905870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DCDC2 NEK10 RIBC1 CEP128 CROCC2

3.24e-051809055c9d2d44d840cd4ec7d42d43446ba2b689e7ec43
ToppCellPND14-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DCDC2 NEK10 RIBC1 CEP128 CROCC2

3.24e-05180905c60e74fbbd815a0251253a19dc520a254b2e1762
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 MBNL1 CHD3 PRRC2C GCC2

3.41e-05182905e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CASP8AP2 MBNL1 CHD3 PRRC2C GCC2

3.41e-051829051710eab3037a87609d21838be2d2d29c3bc36651
ToppCellcellseq2-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-NK|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PRKD2 CEP128 ZNF335 KLHL15 KPNA1

3.41e-051829058ccffcbae28c374fd4161fb0d4cf2c49fae557f6
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KTN1 MBNL1 SETD2 PRRC2C GCC2

3.59e-051849051154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VEPH1 MYZAP ATL1 TSC22D1 BBS12

3.69e-05185905709236097cbfc254796fcc69b5f5178b73dad9bd
ToppCellPBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VEPH1 MYZAP ATL1 TSC22D1 BBS12

3.69e-05185905af078a6c4a3e0b54b7d8ab7b30dcd06053ebfd28
ToppCellmild_COVID-19-Platelet|World / disease group, cell group and cell class (v2)

VEPH1 MYZAP ATL1 TSC22D1 MINDY1

4.08e-05189905038ec3c266b89416bb5b774ba522d916394961da
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

VEPH1 MYZAP ATL1 TSC22D1 MINDY1

4.19e-05190905b719061be370ffc293854f1f6e526bf33cd2f442
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

VEPH1 MYZAP ATL1 TSC22D1 MINDY1

4.19e-05190905427038bae9c7b3a9441c8d59ace69da74e9d37bf
ToppCellCOVID-19_Mild-Hematopoietic_Mega-Platelet|COVID-19_Mild / Disease group, lineage and cell class

VEPH1 MYZAP ATL1 TSC22D1 MINDY1

4.29e-051919056b3cfc670f69ed3e757cbf7498943e549e31326e
ToppCellmild_COVID-19-Platelet|mild_COVID-19 / disease group, cell group and cell class (v2)

VEPH1 MYZAP ATL1 TSC22D1 MINDY1

4.29e-05191905968e2d48969884dd21b8a87f199af94a7410b0dd
ToppCellsevere-low-quality_cells|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MBNL1 RNF213 RSPH10B2 RORA ZNF292

4.51e-051939059337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

MYC MBNL1 CHD3 GCC2 RORA

4.74e-051959054bdedd924564a260841a9153604026b57487c83d
ToppCell(1)_T_cells-(1)_T_CD4_naive|(1)_T_cells / Spleen cell shreds - cell class (v1) and cell subclass (v1)

MYC MBNL1 CHD3 SETD2 GCC2

4.74e-05195905d3fa551bc6f5ee5890af1040415e61ecd5d46201
ToppCellCOVID-19_Severe|World / Disease condition and Cell class

MYC KTN1 MBNL1 CHD3 PRRC2C

4.85e-05196905450ac2aff89c5ca73b8bfbc80663e03be066931f
ToppCelldroplet-Tongue-TONGUE|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT32 KTN1 PPL PRRC2C RORA

4.85e-0519690544a30b1a5f3d8c845e5f3bd17d8102a7449f555b
ToppCelldroplet-Tongue-TONGUE-1m|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT32 KTN1 PPL PRRC2C RORA

4.85e-051969059935bdb10789e8cfc922dca526ca3bf8317fe270
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DCDC2 NEK10 VEPH1 PPL ZFHX4

4.85e-05196905c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT32 KTN1 PPL PRRC2C RORA

4.85e-05196905a85f5f1e6acc798e9e02b1a21e0ffe87a323c333
ToppCellCOVID_non-vent-Lymphocytic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

MYC MBNL1 CHD3 GCC2 RORA

4.97e-05197905c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCellCOVID_vent-Lymphocytic-T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

MYC MBNL1 CHD3 GCC2 RORA

4.97e-05197905ad702e440a74d54cfdcb8bb1c66bd8e0e71ab04e
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

MYC MBNL1 CHD3 GCC2 RORA

5.09e-0519890558f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCellmoderate-Lymphoid-CTL|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

KTN1 MBNL1 RNF213 PRRC2C RORA

5.09e-051989050a868098b1ee4b28b2149ed766acb09e9c0ce14c
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RNF213 PRRC2C RORA SNRNP200 ZNF292

5.22e-05199905f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell(10)_Ciliated-(2)_GFP_FOXI1|(10)_Ciliated / shred by cell type by condition

CEP162 KTN1 PRRC2C GCC2 ZFR

5.22e-0519990561b1ed2db71b96157b92b7535d1955a4033098da
ToppCell(00)_Basal-(2)_GFP_FOXI1|(00)_Basal / shred by cell type by condition

KTN1 PRRC2C GCC2 ZFR ZNF292

5.22e-0519990519674e1eaeb51e4196d847cb62aa437c852951d3
ToppCell(04)_Interm._basal>secr.-(2)_GFP_FOXI1|(04)_Interm._basal>secr. / shred by cell type by condition

KTN1 PRRC2C GCC2 ZFR ZNF292

5.22e-0519990553ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell(05)_Secretory-(2)_GFP_FOXI1|(05)_Secretory / shred by cell type by condition

KTN1 PRRC2C GCC2 KDSR ZNF292

5.22e-05199905d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell(01)_IL1RL1+-(2)_GFP_FOXI1|(01)_IL1RL1+ / shred by cell type by condition

KTN1 PRRC2C GCC2 ZFR ZNF292

5.22e-05199905a2f7d0cabf35b80fe239fae34a77bf9344d5d743
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MBNL1 RNF213 SETD2 PRRC2C ZNF292

5.34e-0520090512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E-|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC9A9 LNX2 LDLRAD3 PTPRT PARP4

5.34e-052009051a3d29a580d1b405a74869a1da3e818c581fc559
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E---L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC9A9 LNX2 LDLRAD3 PTPRT PARP4

5.34e-052009056f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E--|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC9A9 LNX2 LDLRAD3 PTPRT PARP4

5.34e-0520090586705dfc05b3e1576543b93883c88fb55b742855
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E|Neuronal / cells hierarchy compared to all cells using T-Statistic

SLC9A9 LNX2 LDLRAD3 PTPRT PARP4

5.34e-05200905db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCellsevere-CD4+_Tcm|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MYC PRRC2C GCC2 RORA KDSR

5.34e-05200905e83558090a079dd9e40e0d3b5d9917fbd2695ec4
ToppCell343B-Lymphocytic-NK_cells-NK_cell_A2|343B / Donor, Lineage, Cell class and subclass (all cells)

SP3 CEP162 AGGF1 FCHSD1

1.53e-041339048ff1cf0ea1fc33fe8384c0e65c1ee1853b25a2ae
ToppCell(08)_Brush+PNEC-(2)_GFP_FOXI1|(08)_Brush+PNEC / shred by cell type by condition

PRRC2C GCC2 ZFR ZNF292

1.76e-04138904817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell3'_v3-Lung-Lymphocytic_T_CD4-Tfh|Lung / Manually curated celltypes from each tissue

NEK10 TRIM31 RFX8 RORA

1.97e-04142904319812c84fad93276bf093f2ad78db02ae745bf4
Drugisobenzofuran

SP2 SP3 PPL

2.21e-067923CID011378474
DrugLe(x

CLEC4M CD209 TRIM37

5.27e-069923CID004571095
Diseasehereditary spastic paraplegia 3A (implicated_via_orthology)

ATL3 ATL1 ATL2

2.65e-083893DOID:0110791 (implicated_via_orthology)
DiseaseIntellectual Disability

CHD3 ATL1 HNRNPK SETD2 ZNF335 KLHL15 RORA RAI1 ZNF292

8.45e-06447899C3714756
Diseasehereditary spastic paraplegia (implicated_via_orthology)

ATL3 ATL1 ATL2 BORCS7

8.72e-0643894DOID:2476 (implicated_via_orthology)
Diseaseextrapulmonary tuberculosis (is_implicated_in)

CLEC4M CD209

2.69e-053892DOID:0050598 (is_implicated_in)
DiseaseHereditary Sensory Autonomic Neuropathy, Type 1

ATL3 ATL1

2.49e-048892C0020071
Diseaseprostate carcinoma

SP3 MBNL1 TRIM31 RNF213 CHD3 WTAP PPL QSER1 HTR3B KDSR

3.54e-048918910EFO_0001663
Diseaselymphocyte percentage of leukocytes

HIVEP1 MBNL1 CLEC4M LDLRAD3 PRKD3 SETD2 BBS12 ZNF292

9.07e-04665898EFO_0007993
Diseaseacute graft vs. host disease, donor genotype effect measurement

AGGF1 RORA

9.21e-0415892EFO_0004599, EFO_0007892
Diseaseattention deficit hyperactivity disorder, schizophrenia

RORA MINDY1 RAI1

9.68e-0464893EFO_0003888, MONDO_0005090
Diseaseresponse to acetylsalicylate

SETD2 KLHL18

1.05e-0316892GO_1903492
Diseaseautosomal dominant intellectual developmental disorder (is_implicated_in)

SETD2 ZNF292

1.19e-0317892DOID:0060307 (is_implicated_in)
Diseaseneutrophil percentage of leukocytes

HIVEP1 CLEC4M LDLRAD3 PRKD3 SETD2 BBS12 ZNF292

2.49e-03610897EFO_0007990
DiseaseAcute kidney injury

SP2 ATL1

2.58e-0325892HP_0001919
DiseaseNeurodevelopmental Disorders

SETD2 SETD5 ZNF292

2.83e-0393893C1535926
Diseasecalcium measurement

MBNL1 MYZAP ATL1 HINFP RORA MINDY1 KPNA1

2.93e-03628897EFO_0004838

Protein segments in the cluster

PeptideGeneStartEntry
LQQQQQYQYLQQSQE

AMOTL2

256

Q9Y2J4
SQISKQQSNYQDEQG

CEP128

331

Q6ZU80
NLLNDNNIENYSTNA

CAGE1

91

Q8TC20
NQYKENHNRTQQQVE

COPS7B

196

Q9H9Q2
QSISNYLQTQDQTDQ

HTR3B

386

O95264
LYQNAESNNQELRTQ

AGGF1

56

Q8N302
TVEDQYKQLNQQHSQ

ANGPTL3

181

Q9Y5C1
SISQEQSRQDAIYQN

CD209

66

Q9NNX6
NEAVQAQNNTYRTGI

BBS12

71

Q6ZW61
VEEAVQLQYQNACVQ

BBS12

286

Q6ZW61
ENYQDQNNSSINTVK

CASP8AP2

1216

Q9UKL3
EKEEQLAQYQANANQ

KIF16B

951

Q96L93
SGRLSYDQQQQQQQQ

RAI1

271

Q7Z5J4
QENLRQLQDEYDQQQ

RBSN

486

Q9H1K0
SNQQEVLSSVTNENY

QSER1

396

Q2KHR3
NQTNIENNNNKFYII

PARP3

71

Q9Y6F1
RQNVQQNEDATQYEE

RSPH10B

61

P0C881
RQNVQQNEDASQYEE

RSPH10B2

61

B2RC85
NNGIQYVASQAEQNA

LDLRAD3

236

Q86YD5
IVQARAQSNQAQQYS

MTMR11

161

A4FU01
QQVATSSEQLQNYQS

KRT32

296

Q14532
ASEGTINQEIQRYQQ

KIAA1109

3561

Q2LD37
QYVSQAEASALQQQQ

LENG8

71

Q96PV6
DQILQVNNYNISNVS

LNX2

281

Q8N448
NDTNAHQVVQENGVY

NEK10

401

Q6ZWH5
EQEVQKICANSQQYQ

PPL

781

O60437
SDYQTNNNDQAVVEI

VEPH1

46

Q14D04
AQQLQQEEYQQQQAA

MINDY1

416

Q8N5J2
NSQIQENVDIATVYQ

PRKD2

536

Q9BZL6
NCQIQENVDISTVYQ

PRKD3

561

O94806
QIEQLKQQNYQQASS

KTN1

976

Q86UP2
NTNNITELVNYLAND

KNTC1

2156

P50748
SNNVQSLLDAANQYQ

KLHL7

111

Q8IXQ5
QVAYVQQDATAQQAS

PRDM10

86

Q9NQV6
DPQTNSQQQTTQYII

PRDM10

1116

Q9NQV6
DNADVLSQYQLNSIQ

PARP4

51

Q9UKK3
KSQEAQSLQQQRDQY

GOLGA2

601

Q08379
NQQQYEAEEVIQTSS

PTPRT

431

O14522
QSAQYSQQLQAARNE

FCHSD1

196

Q86WN1
AQSTQNVDYNQLQEV

ERVK-10

141

P87889
AQSTQNVDYNQLQEV

ERVK-19

141

Q9YNA8
AQSTQNVDYNQLQEV

ERVK-21

141

P62683
AQSTQNVDYNQLQEV

ERVK-24

141

P63145
AQSTQNVDYNQLQGV

ERVK-5

141

Q9HDB9
AQSTQNVDYNQLQEV

ERVK-6

141

Q7LDI9
AQSTQNVDYNQLQEV

ERVK-7

141

P63130
AQSTQNVDYNQLQEV

ERVK-8

141

P62685
AQSTQNVDYNQLQEV

ERVK-9

141

P63126
AQSTQNADYNQLQEV

HERVK_113

141

P62684
EVDQALNYFQNVHQQ

KLHL15

251

Q96M94
AYNGNLAIDQQNVQS

KLHL18

96

O94889
SSIQVYNLSQNVQED

ATL1

171

Q8WXF7
QEAQSQQEQAQATIS

CROCC2

971

H7BZ55
QVNYNDAAQEDQDNQ

CHD3

1346

Q12873
NSQHYQKNINSLQEE

GCC2

226

Q8IWJ2
QVYNLSQNIQEDDLQ

ATL2

201

Q8NHH9
QEQETLLQGYQQENE

CEP162

711

Q5TB80
IYNLSQNIQEDDLQQ

ATL3

171

Q6DD88
QYQQEAIQKNVEQSS

BORCS7

81

Q96B45
QYQVNQAAAAQAAAT

MBNL1

251

Q9NR56
TNLNSQQVIYSDNNG

MAN2B2

721

Q9Y2E5
ETRQQLAQYQQQQSQ

WTAP

231

Q15007
VVNQTNAQGQQEIVY

HINFP

466

Q9BQA5
QDYNQVENVIKQAQE

KDSR

96

Q06136
EENENNQQNKDYAAV

DCDC2

461

Q9UHG0
SSNLVNIDQNGNVEY

PPEF1

526

O14829
QSFNQLVYHQNEIVQ

UTP20

76

O75691
IEEAAQNYQGQIQEQ

TRIM31

131

Q9BZY9
QLEAAQTSYIQQINN

TRIM37

421

O94972
ELIFSNEYTQAENQN

TES

306

Q9UGI8
IVNQDELAINYQEQA

SLC9A9

581

Q8IVB4
AQGSFQELYQVAQEQ

PLEKHG4

491

Q58EX7
TGLSDISAQVQQYQQ

RFX1

561

P22670
QVDLNQQQYIFQQCE

KPNA1

516

P52294
DEEENFYQQQQQSEL

MYC

26

P01106
QDQIQNAQYLLQNSV

HNRNPK

441

P61978
FDVASVQQQRQEQSY

PLIN3

221

O60664
QQQNPQVYVSQSAAA

PRRC2C

2371

Q9Y520
FTNQYSADVQNALEQ

SETD5

221

Q9C0A6
QVQLQSQELSYQQKQ

TSC22D1

546

Q15714
EVINYTQNSNNETLR

SRPK1

361

Q96SB4
AQSNEQGQVCYQELV

RHBDL1

116

O75783
AQSTQNVDYNQLQEV

ERVK-9

141

P63128
QEQSEQDAIYQNLTQ

CLEC4M

81

Q9H2X3
QTYASDQVQNNGLID

CLCA1

456

A8K7I4
QNQDLDTFQYQEGSV

RNF213

2176

Q63HN8
LLQQYQQYQQNLQES

ZFHX4

3266

Q86UP3
RQQQEQQQAKVDENY

RIBC1

166

Q8N443
QTFLQEEIENYQNKQ

RORA

301

P35398
QYQAVPQIQASNSQT

SP2

131

Q02086
NYIQSPVSEETQAQN

SP3

371

Q02447
IYVETCGQNTENQVN

RFX8

46

Q6ZV50
GETSQNAQINYNIQL

ZNF292

1781

O60281
QQQSYQQAAAAQQIP

PRRC2B

1946

Q5JSZ5
QNIDGQNLYSNENQN

ZNF518A

726

Q6AHZ1
NQQSVSVQQQYSPAQ

SETD2

2276

Q9BYW2
IQTQVFNTVYNSDDN

SNRNP200

1331

O75643
QGATQYTQAQQTRQV

ZFR

196

Q96KR1
NVTLNSAQQAQAHYQ

ZMAT3

76

Q9HA38
SRQSQANAPVYQQNV

WNK2

1291

Q9Y3S1
DNQVQYIISQDGVQH

ZNF335

1221

Q9H4Z2
LQRQQATDYSQEQQG

HIVEP1

646

P15822
VQNDDGNYQTQAISI

ZFYVE9

1176

O95405
AQQEYLENHIQTQSS

MYZAP

141

P0CAP1