Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glucosylceramidase activity	LCT GBA2	9.70e-05	4	81	2	GO:0004348
GeneOntologyMolecularFunction	galactosylceramidase activity	LCT GBA2	1.61e-04	5	81	2	GO:0004336
GeneOntologyMolecularFunction	beta-glucosidase activity	LCT GBA2	2.41e-04	6	81	2	GO:0008422
GeneOntologyMolecularFunction	D-glucose:sodium symporter activity	SLC5A10 SLC5A2	3.37e-04	7	81	2	GO:0005412
GeneOntologyMolecularFunction	nerve growth factor binding	FURIN PCSK6	4.48e-04	8	81	2	GO:0048406
GeneOntologyBiologicalProcess	peptide hormone processing	PCSK5 FURIN PCSK6 PCSK4	1.72e-05	41	78	4	GO:0016486
GeneOntologyBiologicalProcess	signaling receptor ligand precursor processing	PCSK5 FURIN PCSK6 PCSK4	2.74e-05	46	78	4	GO:0140448
GeneOntologyBiologicalProcess	nerve growth factor production	FURIN PCSK6	4.23e-05	3	78	2	GO:0032902
GeneOntologyBiologicalProcess	cytokine precursor processing	PCSK5 FURIN	8.43e-05	4	78	2	GO:0140447
GeneOntologyBiologicalProcess	establishment of body hair planar orientation	CELSR1 ASTN2	8.43e-05	4	78	2	GO:0048105
GeneOntologyBiologicalProcess	establishment of body hair or bristle planar orientation	CELSR1 ASTN2	8.43e-05	4	78	2	GO:0048104
GeneOntologyBiologicalProcess	carbohydrate derivative metabolic process	BPNT1 NUDT1 PCSK6 GNPTAB PARG PANK4 MACROD1 COX11 GXYLT1 CHSY3 PFKP LCT GBA2 LCMT2	1.82e-04	1226	78	14	GO:1901135
GeneOntologyBiologicalProcess	neurotrophin production	FURIN PCSK6	2.10e-04	6	78	2	GO:0032898
MousePheno	Purkinje cell axonal dystrophy	GNPTAB HERC2	2.26e-05	2	67	2	MP:0013159
Domain	Peptidase_S8_Asp-AS	PCSK5 FURIN PCSK6 PCSK4	3.77e-09	6	76	4	IPR023827
Domain	PrprotnconvertsP	PCSK5 FURIN PCSK6 PCSK4	8.78e-09	7	76	4	IPR002884
Domain	P_proprotein	PCSK5 FURIN PCSK6 PCSK4	8.78e-09	7	76	4	PF01483
Domain	S8_pro-domain	PCSK5 FURIN PCSK6 PCSK4	8.78e-09	7	76	4	IPR032815
Domain	-	PCSK5 FURIN PCSK6 PCSK4	8.78e-09	7	76	4	3.30.70.850
Domain	S8_pro-domain	PCSK5 FURIN PCSK6 PCSK4	8.78e-09	7	76	4	PF16470
Domain	RCC1	RCC1L RCCD1 HERC2 HERC1 HERC6	1.44e-08	20	76	5	PF00415
Domain	RCC1_1	RCC1L RCCD1 HERC2 HERC1 HERC6	1.89e-08	21	76	5	PS00625
Domain	RCC1_2	RCC1L RCCD1 HERC2 HERC1 HERC6	1.89e-08	21	76	5	PS00626
Domain	RCC1_3	RCC1L RCCD1 HERC2 HERC1 HERC6	1.89e-08	21	76	5	PS50012
Domain	Reg_chr_condens	RCC1L RCCD1 HERC2 HERC1 HERC6	2.44e-08	22	76	5	IPR000408
Domain	-	RCC1L RCCD1 HERC2 HERC1 HERC6	2.44e-08	22	76	5	2.130.10.30
Domain	RCC1/BLIP-II	RCC1L RCCD1 HERC2 HERC1 HERC6	3.10e-08	23	76	5	IPR009091
Domain	Peptidase_S8_His-AS	PCSK5 FURIN PCSK6 PCSK4	3.14e-08	9	76	4	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK5 FURIN PCSK6 PCSK4	3.14e-08	9	76	4	IPR023828
Domain	Peptidase_S8_subtilisin-rel	PCSK5 FURIN PCSK6 PCSK4	5.22e-08	10	76	4	IPR015500
Domain	SUBTILASE_ASP	PCSK5 FURIN PCSK6 PCSK4	5.22e-08	10	76	4	PS00136
Domain	SUBTILASE_HIS	PCSK5 FURIN PCSK6 PCSK4	5.22e-08	10	76	4	PS00137
Domain	SUBTILASE_SER	PCSK5 FURIN PCSK6 PCSK4	5.22e-08	10	76	4	PS00138
Domain	-	PCSK5 FURIN PCSK6 PCSK4	8.17e-08	11	76	4	3.40.50.200
Domain	Peptidase_S8/S53_dom	PCSK5 FURIN PCSK6 PCSK4	8.17e-08	11	76	4	IPR000209
Domain	Peptidase_S8	PCSK5 FURIN PCSK6 PCSK4	8.17e-08	11	76	4	PF00082
Domain	Propept_inh	PCSK5 FURIN PCSK6 PCSK4	5.79e-07	17	76	4	IPR009020
Domain	Furin_repeat	PCSK5 FURIN PCSK6 PCSK4	7.42e-07	18	76	4	IPR006212
Domain	FU	PCSK5 FURIN PCSK6 PCSK4	7.42e-07	18	76	4	SM00261
Domain	Na/solute_symporter_CS	SLC5A5 SLC5A10 SLC5A2	3.57e-06	8	76	3	IPR018212
Domain	-	PCSK5 FURIN PCSK6 HERC2 PCSK4	1.18e-05	73	76	5	2.60.120.260
Domain	NA_SOLUT_SYMP_2	SLC5A5 SLC5A10 SLC5A2	1.39e-05	12	76	3	PS00457
Domain	SSF	SLC5A5 SLC5A10 SLC5A2	1.39e-05	12	76	3	PF00474
Domain	Na/solute_symporter	SLC5A5 SLC5A10 SLC5A2	1.39e-05	12	76	3	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A5 SLC5A10 SLC5A2	1.39e-05	12	76	3	PS50283
Domain	PLAC	PCSK5 ADAMTS19 PCSK6	2.28e-05	14	76	3	PF08686
Domain	Galactose-bd-like	PCSK5 FURIN PCSK6 HERC2 PCSK4	4.04e-05	94	76	5	IPR008979
Domain	PLAC	PCSK5 ADAMTS19 PCSK6	5.99e-05	19	76	3	PS50900
Domain	PLAC	PCSK5 ADAMTS19 PCSK6	5.99e-05	19	76	3	IPR010909
Domain	HECT	HERC2 HERC1 HERC6	1.77e-04	27	76	3	PF00632
Domain	HECTc	HERC2 HERC1 HERC6	1.77e-04	27	76	3	SM00119
Domain	HECT_dom	HERC2 HERC1 HERC6	1.77e-04	27	76	3	IPR000569
Domain	HECT	HERC2 HERC1 HERC6	1.77e-04	27	76	3	PS50237
Domain	GF_recep_IV	PCSK5 PCSK6	2.43e-04	6	76	2	PF14843
Domain	GF_recep_IV	PCSK5 PCSK6	2.43e-04	6	76	2	IPR032778
Domain	Growth_fac_rcpt_	PCSK5 CELSR1 FURIN PCSK6 PCSK4	4.37e-04	156	76	5	IPR009030
Domain	NA_SOLUT_SYMP_1	SLC5A5 SLC5A2	8.78e-04	11	76	2	PS00456
Domain	SH3	MYO15B ABL2 MYO1F MAP3K21 ARHGAP33	1.88e-03	216	76	5	SM00326
Domain	SH3	MYO15B ABL2 MYO1F MAP3K21 ARHGAP33	1.88e-03	216	76	5	PS50002
Domain	SH3_domain	MYO15B ABL2 MYO1F MAP3K21 ARHGAP33	2.03e-03	220	76	5	IPR001452
Domain	-	GALK2 TOP2B	3.26e-03	21	76	2	3.30.230.10
Domain	Ribosomal_S5_D2-typ_fold_subgr	GALK2 TOP2B	3.58e-03	22	76	2	IPR014721
Domain	SH3_9	MYO1F MAP3K21 ARHGAP33	3.96e-03	78	76	3	PF14604
Domain	SH3_1	ABL2 MYO1F MAP3K21 ARHGAP33	4.50e-03	164	76	4	PF00018
Domain	SH2	SOCS2 ABL2 SHC1	8.11e-03	101	76	3	PF00017
Pathway	REACTOME_ASSEMBLY_OF_ACTIVE_LPL_AND_LIPC_LIPASE_COMPLEXES	PCSK5 FURIN PCSK6	1.01e-05	11	57	3	MM15559
Pathway	REACTOME_ASSEMBLY_OF_ACTIVE_LPL_AND_LIPC_LIPASE_COMPLEXES	PCSK5 FURIN PCSK6	5.80e-05	19	57	3	M27839
Pathway	REACTOME_SIGNALING_BY_NODAL	FURIN PCSK6 GDF1	1.05e-04	23	57	3	M511
Pathway	REACTOME_PLASMA_LIPOPROTEIN_REMODELING	PCSK5 FURIN PCSK6	1.35e-04	25	57	3	MM15562
Pathway	KEGG_GALACTOSE_METABOLISM	GALK2 PFKP LCT	1.53e-04	26	57	3	M4377
Pathway	REACTOME_SIGNALING_BY_NTRKS	PCSK5 FURIN PCSK6 SHC1	2.36e-04	75	57	4	MM14652
Pathway	REACTOME_PLASMA_LIPOPROTEIN_REMODELING	PCSK5 FURIN PCSK6	3.43e-04	34	57	3	M27842
Pubmed	Proteolytic processing in the secretory pathway.	PCSK5 FURIN PCSK6 PCSK4	9.50e-10	7	81	4	10409610
Pubmed	The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.	PCSK5 FURIN PCSK6 PCSK4	9.50e-10	7	81	4	7819324
Pubmed	Chromosomal assignment of the genes for proprotein convertases PC4, PC5, and PACE 4 in mouse and human.	PCSK5 FURIN PCSK6 PCSK4	1.90e-09	8	81	4	7782070
Pubmed	Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.	PCSK5 FURIN PCSK6 PCSK4	1.90e-09	8	81	4	9885250
Pubmed	The activation and physiological functions of the proprotein convertases.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	18343183
Pubmed	The prohormone theory and the proprotein convertases: it is all about serendipity.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	21805236
Pubmed	The proprotein convertases, 20 years later.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	21805237
Pubmed	The biology and therapeutic targeting of the proprotein convertases.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	22679642
Pubmed	The multifaceted proprotein convertases: their unique, redundant, complementary, and opposite functions.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	23775089
Pubmed	SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.	PCSK5 FURIN PCSK6 PCSK4	3.41e-09	9	81	4	8698813
Pubmed	Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.	PCSK5 FURIN PCSK6 PCSK4	5.67e-09	10	81	4	16163737
Pubmed	Comparative cellular processing of the human immunodeficiency virus (HIV-1) envelope glycoprotein gp160 by the mammalian subtilisin/kexin-like convertases.	PCSK5 FURIN PCSK6	1.22e-08	3	81	3	8670066
Pubmed	CDMP1/GDF5 has specific processing requirements that restrict its action to joint surfaces.	PCSK5 FURIN PCSK6	4.86e-08	4	81	3	16829522
Pubmed	Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases.	PCSK5 FURIN PCSK6	4.86e-08	4	81	3	8615794
Pubmed	Neurotrophin secretion: current facts and future prospects.	PCSK5 FURIN PCSK6	4.86e-08	4	81	3	12787574
Pubmed	The proprotein convertases furin and PACE4 play a significant role in tumor progression.	PCSK5 FURIN PCSK6	4.86e-08	4	81	3	10900462
Pubmed	Retroviral envelope glycoprotein processing: structural investigation of the cleavage site.	PCSK5 FURIN PCSK6	4.86e-08	4	81	3	9521771
Pubmed	Regulation of prohepcidin processing and activity by the subtilisin-like proprotein convertases Furin, PC5, PACE4 and PC7.	PCSK5 FURIN PCSK6	1.21e-07	5	81	3	18664504
Pubmed	Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.	PCSK5 FURIN PCSK6	1.21e-07	5	81	3	9242664
Pubmed	Proprotein convertase expression and localization in epidermis: evidence for multiple roles and substrates.	PCSK5 FURIN PCSK6	1.21e-07	5	81	3	11380615
Pubmed	The new enzymology of precursor processing endoproteases.	FURIN PCSK6 PCSK4	1.21e-07	5	81	3	1429684
Pubmed	Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.	PCSK5 FURIN PCSK6	2.42e-07	6	81	3	8940009
Pubmed	Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.	PCSK5 FURIN PCSK6	2.42e-07	6	81	3	9291583
Pubmed	Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.	PCSK5 FURIN PCSK6	6.76e-07	8	81	3	10037747
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PPP1R26 PCSK5 CELSR1 ARAP3 SPRED2 FURIN SHC1 EML2 HERC2 HERC1 GBA2 WNK2 ARHGAP33	1.59e-06	1105	81	13	35748872
Pubmed	Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.	PCSK5 PCSK6	5.36e-06	2	81	2	18061232
Pubmed	Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.	FURIN PCSK6	5.36e-06	2	81	2	17909005
Pubmed	In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.	PCSK5 FURIN	5.36e-06	2	81	2	34149625
Pubmed	Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene.	PCSK5 PCSK4	5.36e-06	2	81	2	11776387
Pubmed	Enhanced UV-induced skin carcinogenesis in transgenic mice overexpressing proprotein convertases.	FURIN PCSK6	5.36e-06	2	81	2	23441131
Pubmed	Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases.	PCSK5 FURIN	5.36e-06	2	81	2	10888676
Pubmed	Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.	PCSK5 PCSK6	5.36e-06	2	81	2	8335106
Pubmed	Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15.	FURIN PCSK6	5.36e-06	2	81	2	1741956
Pubmed	Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4.	PCSK5 PCSK6	5.36e-06	2	81	2	8468318
Pubmed	Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization.	FURIN PCSK4	5.36e-06	2	81	2	8422932
Pubmed	Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.	PCSK5 FURIN PCSK6	6.67e-06	16	81	3	20876279
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	JPH1 RCC1L AARS2 TTLL5 GHITM PANK4 SHC1 COX11 CPOX ARMCX4 HERC2 HERC1 COIL HNRNPAB	8.55e-06	1496	81	14	32877691
Pubmed	Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.	PCSK5 FURIN PCSK6	1.35e-05	20	81	3	23918928
Pubmed	In vivo evidence that furin from hepatocytes inactivates PCSK9.	PCSK5 FURIN	1.60e-05	3	81	2	21147780
Pubmed	The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.	PCSK5 FURIN	1.60e-05	3	81	2	16912035
Pubmed	LncRNA TUG1 reverses LPS-induced cell apoptosis and inflammation of macrophage via targeting MiR-221-3p/SPRED2 axis.	SPRED2 TUG1	1.60e-05	3	81	2	32841583
Pubmed	Thrombin activation of protein C requires prior processing by a liver proprotein convertase.	PCSK5 FURIN	1.60e-05	3	81	2	28468828
Pubmed	Maturation of HIV envelope glycoprotein precursors by cellular endoproteases.	PCSK5 PCSK6	1.60e-05	3	81	2	11063880
Pubmed	Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains.	PCSK5 FURIN	1.60e-05	3	81	2	11723118
Pubmed	Subtilisin-like proprotein convertases, PACE4 and PC8, as well as furin, are endogenous proalbumin convertases in HepG2 cells.	FURIN PCSK6	1.60e-05	3	81	2	10050053
Pubmed	ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.	ABL2 SHC1	1.60e-05	3	81	2	25691660
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HERC2 HERC1 HERC6	3.04e-05	26	81	3	26949039
Pubmed	Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.	FURIN PCSK4	3.20e-05	4	81	2	10701998
Pubmed	Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport.	PCSK5 FURIN	3.20e-05	4	81	2	23686857
Pubmed	Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.	PARG MACROD1	3.20e-05	4	81	2	23474714
Pubmed	Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.	FURIN PCSK6	3.20e-05	4	81	2	26283733
Pubmed	Proprotein convertase furin regulates osteocalcin and bone endocrine function.	PCSK5 FURIN	3.20e-05	4	81	2	28972540
Pubmed	Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.	PCSK5 FURIN	3.20e-05	4	81	2	18245819
Pubmed	Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.	PCSK5 FURIN	3.20e-05	4	81	2	15911696
Pubmed	Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation.	FURIN PCSK6	5.33e-05	5	81	2	18772886
Pubmed	Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.	PARG TOP2B	5.33e-05	5	81	2	21228215
Pubmed	Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.	ADRA2A SHC1	5.33e-05	5	81	2	10896916
Pubmed	The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.	HERC1 HERC6	5.33e-05	5	81	2	15676274
Pubmed	Genetic differences between five European populations.	HERC2 LCT	7.99e-05	6	81	2	20616560
Pubmed	Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation.	MBP SHC1	7.99e-05	6	81	2	10362356
Pubmed	Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.	ARAP3 MYO1F	7.99e-05	6	81	2	11804589
Pubmed	The cysteine-rich domain of the secreted proprotein convertases PC5A and PACE4 functions as a cell surface anchor and interacts with tissue inhibitors of metalloproteinases.	PCSK5 PCSK6	7.99e-05	6	81	2	16135528
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	SLC5A5 PCSK5 MYO15B ZNF497 USHBP1 KRT36 ARHGAP33 KRT73	1.12e-04	630	81	8	36949045
Pubmed	The ancestral gene for transcribed, low-copy repeats in the Prader-Willi/Angelman region encodes a large protein implicated in protein trafficking, which is deficient in mice with neuromuscular and spermiogenic abnormalities.	HERC2 HERC1	1.12e-04	7	81	2	9949213
Pubmed	SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence.	SHC1 PCSK4	1.12e-04	7	81	2	20622265
Pubmed	Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment.	FURIN PCSK6	1.12e-04	7	81	2	15505202
Pubmed	Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZNF469 MYO15B BRSK1 MAP3K21	1.17e-04	107	81	4	11347906
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	SUGCT NUDT1 DMKN MACROD1 COX11 EML2 TUG1 SRRM3 HNRNPAB SPRN	1.30e-04	1021	81	10	26760575
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PPP1R26 MYO15B AARS2 GNPTAB ASTN2 GBA2 LCMT2	1.55e-04	493	81	7	15368895
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	PPP1R26 QSOX1 RCC1L AARS2 USHBP1 CLK3 SHC1 PFKP	2.05e-04	689	81	8	36543142
Pubmed	PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation.	FURIN PCSK6	2.38e-04	10	81	2	26416966
Pubmed	Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk.	MBP SHC1	2.91e-04	11	81	2	10464310
Pubmed	Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.	C19orf12 HERC2 LCMT2	2.93e-04	55	81	3	29997285
Pubmed	Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.	BPNT1 RCC1L AARS2 SUGCT NUDT1 C19orf12 GHITM MACROD1 COX11 CPOX	3.05e-04	1136	81	10	34800366
Pubmed	Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin.	PCSK5 FURIN	3.48e-04	12	81	2	15606899
Pubmed	Pathway analysis in HEK 293T cells overexpressing HIV-1 tat and nucleocapsid.	PCSK5 SHC1	4.11e-04	13	81	2	19884766
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	PCSK5 QSOX1 ZSWIM8 USHBP1 MBP COIL WNK2	5.48e-04	608	81	7	16713569
Pubmed	Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.	AARS2 SUGCT	5.52e-04	15	81	2	22277967
Pubmed	Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.	DMKN ARHGAP33	6.29e-04	16	81	2	11441184
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	SOCS2 ABL2 SHC1	6.73e-04	73	81	3	24728074
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	SOCS2 ABL2 SHC1	7.86e-04	77	81	3	22973453
Pubmed	Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.	FURIN GDF1	8.00e-04	18	81	2	17936261
Pubmed	PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke.	PCSK5 FURIN	8.00e-04	18	81	2	21518694
Pubmed	The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4.	FURIN PCSK6	8.93e-04	19	81	2	16950123
Pubmed	Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning.	FURIN PCSK6	9.91e-04	20	81	2	15829518
Pubmed	Extraembryonic proteases regulate Nodal signalling during gastrulation.	FURIN PCSK6	1.09e-03	21	81	2	12447384
Pubmed	Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.	FURIN PCSK6	1.09e-03	21	81	2	18781635
Pubmed	Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.	ADRA2A MBP	1.09e-03	21	81	2	1676978
Pubmed	Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.	ABL2 HNRNPAB	1.20e-03	22	81	2	26420826
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	HERC2 LCT	1.20e-03	22	81	2	19174780
Pubmed	The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.	FURIN PCSK6	1.20e-03	22	81	2	21896659
Pubmed	Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1.	ABL2 SHC1	1.43e-03	24	81	2	20624904
Pubmed	KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.	KCTD2 PFKP	1.43e-03	24	81	2	23209302
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	HERC2 HERC1 HERC6	1.44e-03	95	81	3	29643511
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	GXYLT1 GBA2	1.55e-03	25	81	2	2283726
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	PCSK5 TGM3 FURIN KCTD2 PCSK4 HNRNPAB WNK2	1.58e-03	730	81	7	34857952
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	PCSK5 QSOX1 PCSK6	1.67e-03	100	81	3	25807483
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	GXYLT1 GBA2	1.68e-03	26	81	2	8218172
Pubmed	Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.	ABL2 MBP	1.95e-03	28	81	2	18067320
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	HERC2 LCT	1.95e-03	28	81	2	19422935
Interaction	PMCH interactions	PCSK5 FURIN PCSK6 HERC2	3.38e-06	26	81	4	int:PMCH
Cytoband	5q23.3	ADAMTS19 CHSY3	2.76e-04	14	81	2	5q23.3
Cytoband	17q25.1	MYO15B KCTD2 HID1	4.09e-04	81	81	3	17q25.1
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 FURIN PCSK6 PCSK4	6.45e-09	9	50	4	973
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CELSR1 MYO15B SLC5A10 LINC00482 GNPTAB CHSY3 KRT73	7.69e-09	142	81	7	e5608bbbc04edcdaafe1affc4db7f9d8edba04d9
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SLC5A5 ADRA2A MSLNL SUGCT DMKN LCT PCSK4	1.48e-08	156	81	7	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SLC5A5 ADRA2A MSLNL SUGCT DMKN LCT PCSK4	1.48e-08	156	81	7	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CELSR1 MYO15B SLC5A10 LINC00482 KRT73 SLC5A2	1.12e-07	125	81	6	9e98dcfdc768ae492f453efc08926164bbb0a909
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_C\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	PCSK5 QSOX1 GNPTAB MYO1F	7.27e-06	68	81	4	1f432e77d83bf6900c29c5c07fefc8662440490b
ToppCell	metastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	PCSK5 CELSR1 SUGCT RCCD1 C19orf12	1.13e-05	161	81	5	e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SUGCT CHSY3 POLA2 COIL HNRNPAB	2.05e-05	182	81	5	d1c3cc2942faec7527a3c25869fd65c17899e5e4
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SUGCT CHSY3 POLA2 COIL HNRNPAB	2.05e-05	182	81	5	92f83f29e358000cd86a709eb8b6199761ffe8bd
ToppCell	5'-Airway_Nasal-Epithelial-Airway_epithelium-brush_cell_of_trachebronchial_tree-Tuft-Tuft_L.0.7.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SUGCT CHSY3 POLA2 COIL HNRNPAB	2.05e-05	182	81	5	02baca9a72c7b559c3e452693b3b134af804c868
ToppCell	COVID-19-kidney-PCT-S1/S2\|kidney / Disease (COVID-19 only), tissue and cell type	PCSK5 SLC5A10 SUGCT ASTN2 SLC5A2	2.16e-05	184	81	5	dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PCSK5 CELSR1 SLC5A10 SUGCT SLC5A2	2.27e-05	186	81	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 IFI27L1 TGM3 FURIN HID1	2.33e-05	187	81	5	ab109aa51beae3df474c15002e70361f328cadad
ToppCell	facs-Large_Intestine-Distal-18m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	QSOX1 IFI27L1 TGM3 FURIN HID1	2.33e-05	187	81	5	a4c408fc941d2e8a811a26aa916c0b3e3341163a
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOCS2 PCSK5 C11orf96 BRSK1 SPRN	2.58e-05	191	81	5	9d3fa8d8138700640cc7927521c7635299df697d
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOCS2 PCSK5 C11orf96 BRSK1 SPRN	2.58e-05	191	81	5	d04ed1e04b8cb904237d8e8388fe7740c724237b
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell-pulmonary_interstitial_myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOCS2 PCSK5 C11orf96 BRSK1 SPRN	2.71e-05	193	81	5	2b80991e7ba7640f7ab2139d30e4c54d8e533862
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast-myofibroblast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SOCS2 PCSK5 C11orf96 BRSK1 SPRN	2.71e-05	193	81	5	90cfc34c2d0d7c70f071703d35db1d6037961481
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ZNF497 SCAMP5 HID1 PFKP WNK2	3.07e-05	198	81	5	dd0465b45b02cb8edf0914d19afb52fcaaeb012c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	QSOX1 ADAMTS19 GNPTAB ASTN2 WNK2	3.22e-05	200	81	5	7c2d499af60654b7b28f172ac2c914ad49fb74b4
Disease	glucoside xylosyltransferase 1 measurement	GNPTAB GXYLT1	1.91e-05	3	75	2	EFO_0801629
Disease	VACTERL association (implicated_via_orthology)	PCSK5 QSOX1	9.50e-05	6	75	2	DOID:14679 (implicated_via_orthology)
Disease	ovarian serous carcinoma	GALK2 USHBP1 RCCD1	2.21e-04	46	75	3	EFO_1001516
Disease	vital capacity	SOCS2 PCSK5 ADAMTS19 SPRED2 SUGCT CLK3 MYO1F ASTN2 CHSY3 LCT	1.12e-03	1236	75	10	EFO_0004312
Disease	unipolar depression, bipolar disorder, schizophrenia	PCSK5 ADAMTS19	1.18e-03	20	75	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	Antimigraine preparation use measurement	SUGCT ASTN2	1.30e-03	21	75	2	EFO_0009939
Disease	colon adenocarcinoma (is_marker_for)	PCSK5 ABHD5	1.84e-03	25	75	2	DOID:234 (is_marker_for)
Disease	eye measurement	ZNF469 HERC1	2.15e-03	27	75	2	EFO_0004731

Protein segments in the cluster

Peptide	Gene	Start	Entry
TCLFSGRGGGRGLWT	SUGCT	21	Q9HAC7
GGTSGIDGGQVGRAW	USHBP1	571	Q8N6Y0
GAVGGLLGAWMTSGQ	C19orf12	66	Q9NSK7
GFGAGRWNGFGGKVQ	NUDT1	26	P36639
FTAWNAAIGGAAGGG	ARAP3	891	Q8WWN8
AGGGWSGITGFFTPR	ABL2	741	P42684
AAGSGRGARSGEWGL	CLK3	126	P49761
FVGWASAGLAVLGGS	CLDN19	166	Q8N6F1
HSLAVGGTGGWSARG	CELSR1	2416	Q9NYQ6
GRTIWGVLGLGAFGF	BPNT1	166	O95861
GIGTWARAGEQASGG	ARMCX4	1176	Q5H9R4
ARAGEQASGGLWAGG	ARMCX4	1181	Q5H9R4
IGWSGARAGAGAGTG	ASTN2	81	O75129
VYSCGWGADGQTGLG	RCC1L	251	Q96I51
AGQVFSWGGGRHGQL	RCCD1	176	A6NED2
GRGRGQWLQVLGGGF	QSOX1	691	O00391
GWVRGVGGGGSARAQ	ADAMTS19	61	Q8TE59
SISFNVASGSGWAGG	KRT73	56	Q86Y46
GGGTGSIGVGQPWQF	GNPTAB	481	Q3T906
GRWFVAGGAAVGLGA	GHITM	81	Q9H3K2
LSAGGSGTIYGWGHN	HERC2	3946	O95714
GLNEGVGQGIWFRGR	FER1L4	326	A9Z1Z3
GGWELSVAQAGQGAG	GDF1	161	P27539
RTVWSFGGGDNGKLG	HERC1	581	Q15751
GGTYQGQWAGGMRHG	JPH1	126	Q9HDC5
GRGGLGTLFIWASGN	PCSK4	286	Q6UW60
RGLGSVFVWASGNGG	PCSK5	301	Q92824
GLGSIFVWASGNGGR	PCSK6	336	P29122
ATGNWGCGAFGGDAR	PARG	866	Q86W56
VGGWTGQGGSILGTK	PFKP	466	Q01813
KFGAQGSRLTGAGWG	GALK2	391	Q01415
ASWLAGGGRGAVRGA	GXYLT1	46	Q4G148
VFAWGAGSEGQLGIG	HERC6	96	Q8IVU3
TAGAAGWRRSGSNGG	COIL	361	P38432
STGAFNVEGGWAEGG	LCT	391	P09848
IGGFAGTALGAWLGS	IFI27L1	86	Q96BM0
VASGWLGSQGSGAGK	MSLNL	671	Q96KJ4
SIGGGTFWGLGALLT	PANK4	216	Q9NVE7
TLEPGWQFGSAGGRS	MYO15B	1456	Q96JP2
WQFGSAGGRSGLFPA	MYO15B	1461	Q96JP2
PGGSSWKTFFALGRG	ARHGAP33	586	O14559
GTLLTWTYRGGQGGR	LINC00482	111	Q8N8I6
AWETSGGHGIFGSQG	DMKN	141	Q6E0U4
GIGGGTITRGWRGQF	GBA2	156	Q9HCG7
SGTGGAERGLRWLGT	COX11	41	Q9Y6N1
GRGGLGSIFVWASGN	FURIN	281	P09958
GRGFTRGSWGFLPFN	DGAT2L6	266	Q6ZPD8
GGGVGGAAWRSRLNS	BRSK1	541	Q8TDC3
RTSAGVGAWGAAAVG	MACROD1	56	Q9BQ69
VGAWGAAAVGRTAGV	MACROD1	61	Q9BQ69
SRFSWGAEGQRPGFG	MBP	246	P02686
SGGNLYVWGKGGNRI	EML2	271	O95834
WLIGGGGATNFGLAF	SCAMP5	61	Q8TAC9
GGGGLRAWSQRSAAG	CPOX	31	P36551
GFVGSGGWFCEGSFN	KRT36	76	O76013
GGGGAARWVRLNVGG	KCTD2	66	Q14681
SGWGSPQRNGGSGQR	SRRM3	306	A6NNA2
ASRGRGWTGAAAGAG	HNRNPAB	26	Q99729
AGVGGGNGALTWVTL	TOP2B	11	Q02880
GAGGFGQVYRATWQG	MAP3K21	131	Q5TCX8
GFFWSTVPGAGRGGQ	HID1	116	Q8IV36
NGGEGTRSQWGTAGS	SOCS2	11	O14508
KGVSWGGRQAGLFSP	PPP1R26	1091	Q5T8A7
LAQGVSWSGRGGAGN	POLA2	176	Q14181
GGKAWGSRVVAQGTG	AARS2	951	Q5JTZ9
GVLAGNWSGTYTGGR	TGM3	231	Q08188
LHGFGGGLGLWALNF	ABHD5	81	Q8WTS1
ASWNGTEAPGGGARA	ADRA2A	26	P08913
LGAGGFDTSIQGWGL	CHSY3	791	Q70JA7
WRGAGGAGEGAVTFP	C11orf96	166	Q7Z7L8
TRGLSEGAVSGGWGA	ZNF497	26	Q6ZNH5
GTGAASGLAVAGFEW	SLC5A2	86	P31639
VSTGIGLWVGLARGG	SLC5A5	26	Q92911
GSGAAGGLAVAGFEW	SLC5A10	81	A0PJK1
AAGAAAGLAAGSGWR	SPRN	76	Q5BIV9
RTQLGGQEGAGGWLV	TUG1	126	A0A6I8PU40
SSGGWFPQEGGGISR	SPRED2	26	Q7Z698
PEWQGGSQGALGTAG	ZNF469	511	Q96JG9
ALGSRGGYNGRGWGS	ZSWIM8	1116	A7E2V4
ALGEARGGGAAFSWG	nan	176	Q6ZR54
ASDGGGARGQGWTVY	WNK2	2066	Q9Y3S1
TWQGGALIAGGLGAS	LCMT2	541	O60294
GGQLGGEEWTRHGSF	SHC1	126	P29353
PGSRSLQTGGFAWEG	TTLL5	1106	Q6EMB2
KEGWGGGGTRSVTFS	MYO1F	881	O00160