Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

RDH16 HSD17B6

7.71e-068112GO:0047023
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

RDH16 HSD17B6

9.91e-069112GO:0047044
GeneOntologyMolecularFunctionelectron transfer activity

RDH16 HSD17B6 STEAP4

3.72e-05124113GO:0009055
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DYNC1H1 DNAH3

4.20e-0518112GO:0008569
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

RDH16 HSD17B6

7.56e-0524112GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

RDH16 HSD17B6

8.90e-0526112GO:0004022
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DYNC1H1 DNAH3

1.03e-0428112GO:0051959
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

RDH16 HSD17B6

1.19e-0430112GO:0018455
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

RDH16 HSD17B6

1.44e-0433112GO:0033764
GeneOntologyMolecularFunctiondynein intermediate chain binding

DYNC1H1 DNAH3

1.82e-0437112GO:0045505
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

RDH16 HSD17B6

2.02e-0439112GO:0016229
GeneOntologyMolecularFunctionmicrotubule motor activity

DYNC1H1 DNAH3

6.53e-0470112GO:0003777
GeneOntologyMolecularFunctioncytoskeletal motor activity

DYNC1H1 DNAH3

1.84e-03118112GO:0003774
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

RDH16 HSD17B6

2.13e-03127112GO:0016616
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

RDH16 HSD17B6

2.50e-03138112GO:0016614
GeneOntologyMolecularFunctionoxidoreductase activity

RDH16 HSD17B6 STEAP4

7.37e-03766113GO:0016491
GeneOntologyMolecularFunctionATP hydrolysis activity

DYNC1H1 DNAH3

2.35e-02441112GO:0016887
GeneOntologyCellularComponentdynein complex

DYNC1H1 DNAH3

4.25e-0454122GO:0030286
GeneOntologyCellularComponentplasma membrane bounded cell projection cytoplasm

DYNC1H1 CFAP54 DNAH3

6.87e-04317123GO:0032838
GeneOntologyCellularComponentcytoplasmic region

DYNC1H1 CFAP54 DNAH3

9.93e-04360123GO:0099568
GeneOntologyCellularComponentmicrotubule associated complex

DYNC1H1 DNAH3

3.70e-03161122GO:0005875
GeneOntologyCellularComponentaxoneme

CFAP54 DNAH3

6.03e-03207122GO:0005930
GeneOntologyCellularComponentciliary plasm

CFAP54 DNAH3

6.09e-03208122GO:0097014
GeneOntologyCellularComponentearly endosome membrane

HSD17B6 STEAP4

6.32e-03212122GO:0031901
DomainDHC_N2

DYNC1H1 DNAH3

3.43e-0514122PF08393
DomainMT

DYNC1H1 DNAH3

3.43e-0514122PF12777
DomainDynein_heavy_dom-2

DYNC1H1 DNAH3

3.43e-0514122IPR013602
DomainATPase_dyneun-rel_AAA

DYNC1H1 DNAH3

3.43e-0514122IPR011704
DomainAAA_8

DYNC1H1 DNAH3

3.43e-0514122PF12780
DomainDynein_heavy_chain_D4_dom

DYNC1H1 DNAH3

3.43e-0514122IPR024317
DomainAAA_5

DYNC1H1 DNAH3

3.43e-0514122PF07728
DomainDynein_HC_stalk

DYNC1H1 DNAH3

3.43e-0514122IPR024743
DomainDynein_heavy

DYNC1H1 DNAH3

3.96e-0515122PF03028
DomainDHC_fam

DYNC1H1 DNAH3

3.96e-0515122IPR026983
DomainDynein_heavy_dom

DYNC1H1 DNAH3

3.96e-0515122IPR004273
Domain-

RDH16 HSD17B6 STEAP4

1.51e-041691233.40.50.720
DomainNAD(P)-bd_dom

RDH16 HSD17B6 STEAP4

1.62e-04173123IPR016040
DomainSc_DH/Rdtase_CS

RDH16 HSD17B6

2.23e-0435122IPR020904
DomainADH_SHORT

RDH16 HSD17B6

5.12e-0453122PS00061
Domainadh_short

RDH16 HSD17B6

5.51e-0455122PF00106
DomainSDR_fam

RDH16 HSD17B6

5.72e-0456122IPR002347
DomainAAA+_ATPase

DYNC1H1 DNAH3

3.70e-03144122IPR003593
DomainAAA

DYNC1H1 DNAH3

3.70e-03144122SM00382
PathwayREACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION

RDH16 HSD17B6

6.84e-052092MM14888
PathwayREACTOME_THE_CANONICAL_RETINOID_CYCLE_IN_RODS_TWILIGHT_VISION

RDH16 HSD17B6

9.10e-052392M27174
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DYNC1H1 DNAH3

9.91e-06141229373155
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

RDH16 DYNC1H1 TRPM3 DNAH3

8.60e-0573612429676528
Pubmed

Searching QTL by gene expression: analysis of diabesity.

RDH16 HSD17B6

2.68e-047112215760467
Pubmed

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative.

RDH16 HSD17B6

2.83e-047312219027726
CytobandEnsembl 112 genes in cytogenetic band chr12q13

RDH16 HSD17B6

5.26e-03423122chr12q13
GeneFamilyShort chain dehydrogenase/reductase superfamily

RDH16 HSD17B6

6.16e-047692743
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKAIN1 TRPM3 CFAP54

8.62e-06155123441fcb6d05364fc6f4973f0b973f1a80b573ce1f
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

FRYL CFAP54 SMAD6

1.51e-0518712340ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D175|Adult / Lineage, Cell type, age group and donor

DOCK6 IL18RAP SMAD6

1.51e-05187123f3548817f2fded5978137bb252cb628ac199e4f6
ToppCellRA-10._Endothelium_II|RA / Chamber and Cluster_Paper

DOCK6 TRPM3 SMAD6

1.56e-05189123c81787a8c662db5d7814c583dd64562857629e81
ToppCellCOVID-19-lung-Artery_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRYL DOCK6 SMAD6

1.59e-0519012307b675befcd1d0a9c90cb17b5d22323468325d51
ToppCellBronchus_Control_(B.)-Stromal-TX-Mesothelial-2|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

NKAIN1 HSD17B6 SMAD6

1.82e-0519912360a653100aff31f7f96796ff2ec634798bfb4b0d
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf|Striatum / BrainAtlas - Mouse McCarroll V32

NKAIN1 IL18RAP

1.99e-0479122a60fcbb278ba629af922c53faf58e4d96c537b15
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)|Striatum / BrainAtlas - Mouse McCarroll V32

NKAIN1 IL18RAP

1.99e-0479122239d34f40c3a96186231f3aabd41c4988af3f372
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3-Excitatory_Neuron.Slc17a7.Pvrl3-Fos_(CA3_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

RDH16 IL18RAP

2.04e-0480122b661644806e225f215047e78ae46d7cee6efde4f
ToppCellPosterior_cortex-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Tfr.Ctps_(Ctps)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

RDH16 NKAIN1

2.58e-04901224d75217fd6b376bfda3300962cbe4875b31ffdaf
ToppCellCOVID-19_Mild-Neutrophil-|COVID-19_Mild / Disease condition and Cell class

IL18RAP STEAP4

4.73e-041221226ce3e9e2868d6cdc4ed90b90b2541b8f51270cac
ToppCellCOVID-19_Mild-Neutrophil|COVID-19_Mild / Disease condition and Cell class

IL18RAP STEAP4

4.73e-04122122bc4346f4caaed153583b0fe8521b45437f5c3049
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL18RAP STEAP4

6.39e-04142122b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NKAIN1 CFAP54

6.48e-041431227a7a9829ba63468c9745904d9e993590051207ab
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RDH16 TRPM3

6.48e-04143122990844ca674d30b2924c74b45bed4fdfb8463fa7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 IL18RAP

6.85e-0414712264fa0753a3a79f492ef8acc6942bf90d379a983f
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

6.94e-04148122d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

6.94e-04148122c8e93b87212f55774223caa385859c566fa1981f
ToppCellCiliated_cells-A-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

CFAP54 DNAH3

7.22e-041511229d03ce73af15ef40c592d19b36aff46bebc14c40
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.22e-0415112281cf939ed4df9574fbfff265e109cb9f947d7e6e
ToppCellLPS-IL1RA-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.22e-041511229cbcbbc22965a9f0be8364e733d205dd64f2a533
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

CFAP54 DNAH3

7.22e-041511228216462e723fec2797387929dde095370947e10a
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|343B / Donor, Lineage, Cell class and subclass (all cells)

RDH16 IL18RAP

7.22e-04151122563439b0278776b82c1836c3de9fa80d1a4109af
ToppCellsevere_COVID-19-NK_CD56bright|World / disease group, cell group and cell class (v2)

RDH16 IL18RAP

7.32e-04152122ab5a4e47b23d16018642d4c9c7f41b30205edf73
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c6-FGF23|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IL18RAP DNAH3

7.32e-041521220652ee3443e6fbb679d2c4f326239ae7c803f924
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TRPM3 SMAD6

7.32e-04152122ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.51e-041541224e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.51e-041541227556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.51e-0415412258072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.51e-041541229ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell18-Distal-Immune-Immune|Distal / Age, Tissue, Lineage and Cell class

RDH16 IL18RAP

7.51e-04154122ecfaed6fbffd1305a2216d48ecb33d8a182a9dd9
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK6 STEAP4

7.61e-04155122d8b5145258f075b15080f8739f537f48dd22225e
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.61e-041551225f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

7.61e-041551220944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK6 STEAP4

7.61e-04155122ced64e26962c5c6e6d539f361fe57ab0b399e999
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HSD17B6 STEAP4

7.61e-0415512282e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

HSD17B6 STEAP4

7.61e-04155122979c1d53b435a82c57d16707eed8ba7346326866
ToppCellprimary_visual_cortex-Non-neuronal-pericyte_cell|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

DOCK6 STEAP4

7.61e-041551220f24ef6486aef354f0911c06932cb01d1a0525ac
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DOCK6 STEAP4

7.71e-041561220b3630fd4479291599e1674e87eba6f93877ac3a
ToppCellNS-moderate-d_07-13-Epithelial-FOXN4+|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CFAP54 DNAH3

7.80e-04157122410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCellsevere_COVID-19-NK_CD56bright|severe_COVID-19 / disease group, cell group and cell class (v2)

RDH16 IL18RAP

7.90e-04158122c2e8d96fc29aa2388b92b4fd81d2726e1f7a053f
ToppCellfacs-Heart-RV-24m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HSD17B6 STEAP4

7.90e-041581222ef43d14ee65d004dc62c12ff209bbe12e4db681
ToppCellAdult-Endothelial-endothelial_cell_of_vein-D122|Adult / Lineage, Cell type, age group and donor

DOCK6 SMAD6

8.10e-041601220cfe130606af433b2aa90e0a20b6c44659dd6fd4
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TRPM3 SMAD6

8.10e-0416012219105debef96ea0c267d6a1d332303ec668ae47e
ToppCellInfluenza_Severe-Neutrophil|Influenza_Severe / Disease group and Cell class

IL18RAP STEAP4

8.20e-0416112298c95b1b85d5427415af2ca8fb14849e97f6e8b5
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSD17B6 STEAP4

8.31e-041621222259e9536147e9cdee772e3a30ba7d104573262c
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CFAP54 DNAH3

8.51e-04164122e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCelldroplet-Kidney-nan-18m-Lymphocytic-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL18RAP STEAP4

8.51e-04164122731b9c7d6f6ecfb14d4a8705e0ddac9fb460d9a8
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRYL STEAP4

8.82e-04167122a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCelllung-Ciliated_Epithelia|lung / shred on tissue and cell subclass

CFAP54 DNAH3

8.82e-0416712226cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCellfacs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH16 HSD17B6

8.82e-041671223e3d8f6df2feefafad5b44ba0ebf5b5a0fe4ed58
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NKAIN1 DNAH3

8.82e-041671223edb0570e583bb527165bcd8a4c25a042054043b
ToppCellfacs-Heart-RV-24m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH16 HSD17B6

8.82e-041671223ad9f3122dbe96580f640388ef920ea209fc2349
ToppCellfacs-Large_Intestine-Distal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH16 DOCK6

8.93e-0416812203896466698a79f7f1ad862cb7e05585260e2a5a
ToppCellfacs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK6 SMAD6

8.93e-0416812206dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D122|Adult / Lineage, Cell type, age group and donor

TRPM3 SMAD6

8.93e-041681228c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPM3 CFAP54

8.93e-04168122a086c306be430adf0632ba53e98cd8014d2de330
ToppCellfacs-Heart-RA-18m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK6 SMAD6

8.93e-041681221002f058a340763e3d8de0bd1f0547a903526ec6
ToppCellInfluenza_Severe-Neutrophil|World / Disease group and Cell class

IL18RAP STEAP4

9.03e-041691226e8e2580e19c96bcf7fa6a6d8c183df65f428396
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP54 IL18RAP

9.03e-041691228bca402e144819cb9a8d431d6bf9429be2fff6d6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NKAIN1 TRPM3

9.03e-04169122319cba07263bf41fcbcbfecd117f91b729394241
ToppCelldroplet-Lung-nan-18m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STEAP4 SMAD6

9.03e-04169122f0f97ca415aef619b8b4b1399ad5e0823267516e
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP54 DNAH3

9.03e-04169122fba841664939c771881ba97f14ef1df6635c04ff
ToppCell3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFAP54 DNAH3

9.03e-0416912214aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HSD17B6 STEAP4

9.03e-04169122a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellCTRL-Myeloid-Neutrophil|Myeloid / Disease state, Lineage and Cell class

IL18RAP STEAP4

9.14e-04170122151dabe1d240dde414c881bf4fa816c69fa1c32d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NKAIN1 TRPM3

9.14e-041701225de2f7d16a05af74ebfb1ca42d0f9c3c3524692d
ToppCelldroplet-Lung-18m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STEAP4 SMAD6

9.14e-04170122683c4aa74689791944b6f3998dba51a4456fbc49
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FRYL SMAD6

9.24e-041711226a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

DOCK6 SMAD6

9.24e-04171122bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK6 SMAD6

9.24e-041711221597459c971d6befa991d59dc66b41b6a522f797
ToppCell356C-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FRYL SMAD6

9.24e-041711229be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSD17B6 STEAP4

9.24e-04171122fd59ac4a39748840b2ee1c930ea475433ff61485
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSD17B6 STEAP4

9.24e-04171122d382430e5cdd0f2aac4fc093d8fe8d66efb4629b
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSD17B6 STEAP4

9.24e-041711224347e6f62c04ea43299893ad4b79719049009a56
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HSD17B6 STEAP4

9.24e-04171122d5960b40ad5b87aaa00c93a6b31cdf41cc4f1375
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-venous_capillary|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK6 SMAD6

9.24e-04171122b3e6e31dfe3623b960ccf692fdbd236fa4039923
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSD17B6 STEAP4

9.35e-041721221ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HSD17B6 STEAP4

9.35e-04172122ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCellCTRL-Myeloid-Neutrophil|CTRL / Disease state, Lineage and Cell class

IL18RAP STEAP4

9.35e-04172122ef3a6fe3b7300959f9f71130200c7fb8741c42b0
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

RDH16 HSD17B6

9.46e-04173122e05cddf5bf63cf419343ff229453327519765be8
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP54 STEAP4

9.46e-04173122d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCell367C-Fibroblasts-Fibroblast-J_(Lipofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

RDH16 HSD17B6

9.46e-0417312274ad5ed33821b8816c9c8e67c50ee4496ba18e2f
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP54 STEAP4

9.46e-041731223c852ffe22f4a5b632463086b08c669310684e80
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

HSD17B6 DNAH3

9.46e-04173122ef8d720b99470fe1953661f6e66bc0366266bdb6
ToppCellsevere_influenza-Neutrophil|severe_influenza / disease group, cell group and cell class (v2)

IL18RAP STEAP4

9.46e-04173122615e266419b9f06e964eff73cb466f05451ba0dd
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NKAIN1 TRPM3

9.46e-041731229a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell356C-Myeloid-Macrophage-FABP4+_Macrophage_4|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

HSD17B6 DNAH3

9.57e-04174122110369f6b78de34a6d934b5b47cecd023347bc80
ToppCellfacs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK6 SMAD6

9.57e-0417412242dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCellfacs-Heart-RA-24m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK6 SMAD6

9.57e-04174122f04edf2ca6788875c9918611e416fb739924382e
ToppCellCOVID-19-kidney-PCT-S3-2|kidney / Disease (COVID-19 only), tissue and cell type

RDH16 HSD17B6

9.57e-041741225aa2fb631505600f37d2b87b02def7be139dc262
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NKAIN1 TRPM3

9.57e-04174122b3cd22e717d178269e6d5bd5ed7b2d945cd8ea25
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FRYL TRPM3

9.57e-04174122f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellCOVID-19-kidney-PCT-S3-2|COVID-19 / Disease (COVID-19 only), tissue and cell type

RDH16 HSD17B6

9.79e-04176122b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCellAdult-Endothelial-endothelial_cell_of_vein|Adult / Lineage, Cell type, age group and donor

DOCK6 SMAD6

9.79e-04176122043683c61c5d1a7f8a4666a612310246bd3d83a2
ToppCellCiliated_cells-B-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

CFAP54 DNAH3

9.90e-04177122c38138fb5ad9766c2d240811210c854338cd612e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Neutrophil|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL18RAP STEAP4

9.90e-04177122ed44b1bf2ffae97f94e944d1b6060d5163eba6a6
ToppCellfacs-Kidney-nan-18m|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RDH16 NKAIN1

9.90e-04177122d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell390C-Endothelial_cells-Endothelial-E|390C / Donor, Lineage, Cell class and subclass (all cells)

DOCK6 SMAD6

1.00e-03178122ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCellFetal_29-31_weeks-Epithelial-ciliated_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CFAP54 DNAH3

1.00e-03178122de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ComputationalNeighborhood of IGF1

RDH16 HSD17B6

1.17e-042672GNF2_IGF1
ComputationalNeighborhood of CYP2B6

RDH16 HSD17B6

4.21e-044972GNF2_CYP2B6
ComputationalNeighborhood of CEBPA

RDH16 HSD17B6

7.19e-046472GNF2_CEBPA
ComputationalNeighborhood of TST

RDH16 HSD17B6

1.89e-0310472GNF2_TST
ComputationalNeighborhood of GSTM1

RDH16 HSD17B6

2.07e-0310972GNF2_GSTM1
ComputationalNeighborhood of LCAT

RDH16 HSD17B6

2.67e-0312472GNF2_LCAT
ComputationalNeighborhood of HPN

RDH16 HSD17B6

3.11e-0313472GNF2_HPN
ComputationalNeighborhood of HPX

RDH16 HSD17B6

3.16e-0313572GNF2_HPX
ComputationalNeighborhood of MAP4K4

DYNC1H1 FRYL

5.07e-0317272GCM_MAP4K4
DrugAndrostane-3,17-diol

RDH16 HSD17B6

3.88e-0518122ctd:D015113
Drug3,4-didehydroretinoic acid

RDH16 HSD17B6

3.88e-0518122CID000447276
DrugRacecadotril [81110-73-8]; Down 200; 10.4uM; PC3; HT_HG-U133A

DOCK6 HSD17B6 STEAP4

1.27e-041941235755_DN
Drugalpha-Santonin [481-06-1]; Up 200; 16.2uM; PC3; HT_HG-U133A

DOCK6 HSD17B6 STEAP4

1.27e-041941234531_UP
DrugAsiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A

NKAIN1 DOCK6 HSD17B6

1.29e-041951237004_DN
DrugTelenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; MCF7; HT_HG-U133A

DOCK6 SMAD6 DNAH3

1.31e-041961237419_DN
DrugAscorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A

NKAIN1 DOCK6 STEAP4

1.31e-041961235407_UP
DrugClemastine fumarate [14976-57-9]; Down 200; 8.6uM; MCF7; HT_HG-U133A

NKAIN1 HSD17B6 SMAD6

1.31e-041961237485_DN
DrugQuinidine hydrochloride monohydrate [6151-40-2]; Down 200; 10.6uM; MCF7; HT_HG-U133A

DOCK6 HSD17B6 SMAD6

1.31e-041961236267_DN
DrugDiethylcarbamazine citrate [1642-54-2]; Down 200; 10.2uM; MCF7; HT_HG-U133A

DOCK6 HSD17B6 DNAH3

1.33e-041971237425_DN
Drugtroglitazone; Up 200; 10uM; SKMEL5; HG-U133A

DOCK6 TRPM3 IL18RAP

1.33e-04197123504_UP
DrugAntipyrine, 4-hydroxy [1672-63-5]; Down 200; 19.6uM; MCF7; HT_HG-U133A

NKAIN1 SMAD6 DNAH3

1.33e-041971231497_DN
DrugDropropizine (R,S) [17692-31-8]; Down 200; 17uM; MCF7; HT_HG-U133A

NKAIN1 DOCK6 DNAH3

1.35e-041981235531_DN
DrugTetrahydroxy-1,4-quinone monohydrate [319-89-1]; Down 200; 21uM; PC3; HT_HG-U133A

DOCK6 HSD17B6 STEAP4

1.35e-041981234078_DN
DrugCarisoprodol [78-44-4]; Up 200; 15.4uM; PC3; HT_HG-U133A

TRPM3 HSD17B6 STEAP4

1.35e-041981236610_UP
DrugMK-886; Down 200; 1uM; MCF7; HG-U133A

HSD17B6 SMAD6 DNAH3

1.37e-04199123264_DN
Drugtetraethylenepentamine pentahydrochloride; Up 200; 100uM; HL60; HG-U133A

RDH16 NKAIN1 DOCK6

1.37e-04199123412_UP
DrugBiliton

DYNC1H1 DNAH3

2.06e-0441122CID000002974
Drugtriethylamine

DYNC1H1 HSD17B6

3.08e-0450122CID000008471
Drug4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile

RDH16 HSD17B6

3.72e-0455122ctd:C575631
Druganethole trithione

RDH16 HSD17B6

4.89e-0463122CID000002194
DrugN,N-dimethylproline

HSD17B6 SMAD6

5.20e-0465122CID000000554
Drug2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester

FRYL IL18RAP STEAP4 SMAD6

6.18e-04807124ctd:C548651
DrugNAD

RDH16 HSD17B6

7.87e-0480122ctd:D009243
Drug5 alpha-androstane

RDH16 HSD17B6

8.67e-0484122CID000094144
Drugolmesartan

DYNC1H1 STEAP4

1.02e-0391122CID000158781
DrugIC261

DYNC1H1 DNAH3

1.13e-0396122CID000003674
Drug3-hydroxyandrostan-17-one

RDH16 HSD17B6

1.27e-03102122CID000000225
Drugflufenamic acid

TRPM3 HSD17B6

1.43e-03108122CID000003371
DrugAC1L1IZE

DYNC1H1 DNAH3

2.09e-03131122CID000004799
Drugdihydrochloride

TRPM3 STEAP4

3.05e-03159122CID000070978
Drugandrostan-3-ol

RDH16 HSD17B6

3.09e-03160122CID000092877
DrugEllipticine [519-23-3]; Up 200; 16.2uM; PC3; HT_HG-U133A

HSD17B6 IL18RAP

3.81e-031781225779_UP
Drugdeferoxamine mesylate salt; Up 200; 100uM; MCF7; HG-U133A

TRPM3 IL18RAP

4.06e-03184122573_UP
Drug5224221; Down 200; 12uM; MCF7; HT_HG-U133A_EA

HSD17B6 DNAH3

4.15e-03186122839_DN
Drugfluphenazine dihydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A

TRPM3 STEAP4

4.15e-031861225597_UP
DrugDimethisoquin hydrochloride [2773-92-4]; Up 200; 13uM; PC3; HT_HG-U133A

TRPM3 IL18RAP

4.20e-031871224207_UP
Drug15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A

SMAD6 DNAH3

4.20e-031871226948_DN
DrugCP-690334-01 [459212-38-5]; Up 200; 10uM; PC3; HT_HG-U133A

RDH16 HSD17B6

4.24e-031881223823_UP
Druggeldanamycin; Down 200; 1uM; HL60; HT_HG-U133A

HSD17B6 SMAD6

4.24e-031881226187_DN
Drug11-cis-retinal

RDH16 HSD17B6

4.28e-03189122CID000001070
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

NKAIN1 SMAD6

4.28e-031891221643_DN
Drugcarbamazepine; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA

DOCK6 HSD17B6

4.33e-03190122952_UP
DrugCID11987713

DYNC1H1 SMAD6

4.33e-03190122CID011987713
Drugtyrphostin AG-825; Up 200; 25.2uM; MCF7; HT_HG-U133A_EA

DOCK6 HSD17B6

4.33e-031901221114_UP
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

DOCK6 SMAD6

4.37e-031911222678_DN
DrugTranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; HL60; HG-U133A

TRPM3 SMAD6

4.37e-031911221417_UP
Diseaseserine measurement

DYNC1H1 SMAD6

8.95e-0535122EFO_0009774
Diseaseage at menopause

DYNC1H1 FRYL HSD17B6

2.18e-04302123EFO_0004704
Diseasemigraine disorder

RDH16 TRPM3 HSD17B6

3.56e-04357123MONDO_0005277
Diseasemigraine disorder, Headache

RDH16 HSD17B6

5.44e-0486122HP_0002315, MONDO_0005277
Diseaseurinary uromodulin measurement

DYNC1H1 DNAH3

6.77e-0496122EFO_0005663
Diseaselifestyle measurement, anxiety disorder measurement

TRPM3 CFAP54

1.37e-03137122EFO_0007795, EFO_0010724
Diseasephospholipid measurement

DOCK6 CFAP54

1.43e-03140122EFO_0004639
Diseasesphingomyelin measurement

DYNC1H1 DOCK6

5.48e-03278122EFO_0010118
Diseasephosphatidylcholine measurement

DYNC1H1 DOCK6

5.72e-03284122EFO_0010226

Protein segments in the cluster

PeptideGeneStartEntry
ITWILLLRYYIHLQR

CFAP54

2796

Q96N23
LYRHWIEIVLLYRTY

IL18RAP

381

O95256
LESLYRLLWVYVIRI

FRYL

356

O94915
LYYLLHWYRERQVVS

HSD17B6

11

O14756
YIEDWVIVHRRYQYL

DOCK6

116

Q96HP0
RLWIHEVYRVFYDRL

DNAH3

2301

Q8TD57
LERYIQRYLVYAILW

DYNC1H1

2486

Q14204
YWEHRTRVGRLYAVY

SMAD6

336

O43541
LYYLLHWYRERQVLS

RDH16

11

O75452
QYRSRYLILYAAWLV

NKAIN1

56

Q4KMZ8
VIYCVNIIYWYIRLL

TRPM3

996

Q9HCF6
LYTLVIPIRYYVRWR

STEAP4

306

Q687X5