Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	KIF18A MACF1 ACTN2 TNNI1 TNNI2 CD2AP	3.08e-04	479	39	6	GO:0003779
GeneOntologyMolecularFunction	phosphatidylinositol 3-kinase regulatory subunit binding	FBXL2 CD2AP	3.33e-04	14	39	2	GO:0036312
GeneOntologyBiologicalProcess	microtubule cytoskeleton organization involved in establishment of planar polarity	BRSK2 BRSK1	1.04e-05	3	39	2	GO:0090176
GeneOntologyCellularComponent	striated muscle thin filament	ACTN2 TNNI1 TNNI2	2.13e-05	27	42	3	GO:0005865
GeneOntologyCellularComponent	myofilament	ACTN2 TNNI1 TNNI2	3.59e-05	32	42	3	GO:0036379
GeneOntologyCellularComponent	troponin complex	TNNI1 TNNI2	1.41e-04	9	42	2	GO:0005861
GeneOntologyCellularComponent	ruffle	KIF18A MACF1 FGD5 CD2AP	7.65e-04	206	42	4	GO:0001726
Domain	LRRC37_N	LRRC37A LRRC37A3 LRRC37A2	3.63e-08	4	40	3	IPR032754
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.63e-08	4	40	3	PF14914
Domain	LRRC37AB_C	LRRC37A LRRC37A3 LRRC37A2	3.63e-08	4	40	3	IPR029423
Domain	LRRC37	LRRC37A LRRC37A3 LRRC37A2	3.63e-08	4	40	3	PF15779
Domain	LRRC37A/B-like	LRRC37A LRRC37A3 LRRC37A2	3.63e-08	4	40	3	IPR015753
Domain	Troponin	TNNI1 TNNI2	6.67e-05	6	40	2	PF00992
Domain	Troponin	TNNI1 TNNI2	6.67e-05	6	40	2	IPR001978
Domain	Actinin_actin-bd_CS	MACF1 ACTN2	1.10e-03	23	40	2	IPR001589
Domain	ACTININ_2	MACF1 ACTN2	1.10e-03	23	40	2	PS00020
Domain	ACTININ_1	MACF1 ACTN2	1.10e-03	23	40	2	PS00019
Domain	Spectrin	MACF1 ACTN2	1.10e-03	23	40	2	PF00435
Domain	LRR_1	LRRC37A FBXL2 LRRC37A3 LRRC37A2	1.21e-03	219	40	4	PF00560
Domain	Spectrin_repeat	MACF1 ACTN2	1.75e-03	29	40	2	IPR002017
Domain	Spectrin/alpha-actinin	MACF1 ACTN2	2.13e-03	32	40	2	IPR018159
Domain	SPEC	MACF1 ACTN2	2.13e-03	32	40	2	SM00150
Domain	Leu-rich_rpt	LRRC37A FBXL2 LRRC37A3 LRRC37A2	2.63e-03	271	40	4	IPR001611
Domain	-	LRRC37A FBXL2 LRRC37A3 LRRC37A2	4.81e-03	321	40	4	3.80.10.10
Domain	L_dom-like	LRRC37A FBXL2 LRRC37A3 LRRC37A2	5.19e-03	328	40	4	IPR032675
Domain	LRR_8	LRRC37A LRRC37A3 LRRC37A2	5.81e-03	171	40	3	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRRC37A LRRC37A3 LRRC37A2	6.39e-03	177	40	3	IPR003591
Domain	LRR_TYP	LRRC37A LRRC37A3 LRRC37A2	6.39e-03	177	40	3	SM00369
Domain	CH	MACF1 ACTN2	8.54e-03	65	40	2	SM00033
Domain	LRR	LRRC37A LRRC37A3 LRRC37A2	9.05e-03	201	40	3	PS51450
Domain	Ca/CaM-dep_Ca-dep_prot_Kinase	BRSK2 BRSK1	9.58e-03	69	40	2	IPR020636
Domain	CH	MACF1 ACTN2	9.85e-03	70	40	2	PF00307
Domain	-	MACF1 ACTN2	1.01e-02	71	40	2	1.10.418.10
Domain	CH	MACF1 ACTN2	1.07e-02	73	40	2	PS50021
Domain	CH-domain	MACF1 ACTN2	1.12e-02	75	40	2	IPR001715
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	ACTN2 TNNI1 TNNI2	3.94e-05	35	27	3	MM15005
Pathway	REACTOME_STRIATED_MUSCLE_CONTRACTION	ACTN2 TNNI1 TNNI2	4.29e-05	36	27	3	M18647
Pathway	WP_STRIATED_MUSCLE_CONTRACTION_PATHWAY	ACTN2 TNNI1 TNNI2	5.05e-05	38	27	3	M39549
Pubmed	Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.	LRRC37A LRRC37A3 LRRC37A2	6.54e-09	4	42	3	22419166
Pubmed	Evolutionary dynamism of the primate LRRC37 gene family.	LRRC37A LRRC37A3 LRRC37A2	1.95e-07	10	42	3	23064749
Pubmed	Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.	ACTN2 HDAC5 TNNI1 TNNI2	7.43e-07	58	42	4	21884692
Pubmed	Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy.	TNNI1 TNNI2	1.42e-06	2	42	2	33683712
Pubmed	cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs.	TNNI1 TNNI2	1.42e-06	2	42	2	2760067
Pubmed	SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release.	BRSK2 BRSK1	1.42e-06	2	42	2	16630837
Pubmed	cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I.	TNNI1 TNNI2	1.42e-06	2	42	2	2365354
Pubmed	Troponin I isoform expression in human and experimental atrial fibrillation.	TNNI1 TNNI2	1.42e-06	2	42	2	15289369
Pubmed	Investigating the regulation of brain-specific kinases 1 and 2 by phosphorylation.	BRSK2 BRSK1	1.42e-06	2	42	2	18339622
Pubmed	Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.	BRSK2 BRSK1	1.42e-06	2	42	2	30307479
Pubmed	Microtubule stabilization specifies initial neuronal polarization.	BRSK2 BRSK1	4.27e-06	3	42	2	18268107
Pubmed	Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.	BRSK2 BRSK1	4.27e-06	3	42	2	22669945
Pubmed	Tissue-specific alternative splicing of ascidian troponin I isoforms. Redesign of a protein isoform-generating mechanism during chordate evolution.	TNNI1 TNNI2	4.27e-06	3	42	2	9405409
Pubmed	Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity.	BRSK2 BRSK1	4.27e-06	3	42	2	20026642
Pubmed	Developmental regulation of troponin I isoform genes in striated muscles of transgenic mice.	TNNI1 TNNI2	4.27e-06	3	42	2	7781893
Pubmed	The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse.	ACTN2 TNNI1 TNNI2	7.93e-06	32	42	3	23369715
Pubmed	Tuberous sclerosis complex proteins control axon formation.	BRSK2 BRSK1	8.53e-06	4	42	2	18794346
Pubmed	Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function.	BRSK2 BRSK1	1.42e-05	5	42	2	15150265
Pubmed	Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.	TNNI1 TNNI2	1.42e-05	5	42	2	9016781
Pubmed	A recombinant monocysteine mutant (Ser to Cys-155) of fast skeletal troponin T: identification by cross-linking of a domain involved in a physiologically relevant interaction with troponins C and I.	TNNI1 TNNI2	1.42e-05	5	42	2	9724539
Pubmed	Troponin I binds polycystin-L and inhibits its calcium-induced channel activation.	TNNI1 TNNI2	1.42e-05	5	42	2	12809519
Pubmed	C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.	BRSK2 BRSK1	1.42e-05	5	42	2	18854318
Pubmed	SAD kinases control the maturation of nerve terminals in the mammalian peripheral and central nervous systems.	BRSK2 BRSK1	2.13e-05	6	42	2	24395778
Pubmed	Mammalian SAD kinases are required for neuronal polarization.	BRSK2 BRSK1	2.13e-05	6	42	2	15705853
Pubmed	Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7.	TNNI1 TNNI2	2.13e-05	6	42	2	8903721
Pubmed	Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.	BRSK2 BRSK1	2.13e-05	6	42	2	21985311
Pubmed	Both smooth and skeletal muscle precursors are present in foetal mouse oesophagus and they follow different differentiation pathways.	TNNI1 TNNI2	2.13e-05	6	42	2	10906778
Pubmed	LKB1 and AMPK regulate synaptic remodeling in old age.	BRSK2 BRSK1	2.13e-05	6	42	2	25086610
Pubmed	Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.	TNNI1 TNNI2	2.13e-05	6	42	2	7958896
Pubmed	Genes encoding troponin I and troponin T are organized as three paralogous pairs in the mouse genome.	TNNI1 TNNI2	2.98e-05	7	42	2	11003710
Pubmed	Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.	MACF1 ACTN2	6.37e-05	10	42	2	33773096
Pubmed	Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.	TNNI1 TNNI2	7.78e-05	11	42	2	7720708
Pubmed	Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.	HDAC5 APLN	7.78e-05	11	42	2	23603510
Pubmed	CHD4 and the NuRD complex directly control cardiac sarcomere formation.	ACTN2 TNNI2	9.32e-05	12	42	2	29891665
Pubmed	Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival.	BRSK2 BRSK1	9.32e-05	12	42	2	23275438
Pubmed	The loss of the kinases SadA and SadB results in early neuronal apoptosis and a reduced number of progenitors.	BRSK2 BRSK1	1.10e-04	13	42	2	29698519
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	TNNI1 TNNI2	1.48e-04	15	42	2	24852826
Pubmed	Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice.	ADCY7 GLRA1	1.48e-04	15	42	2	12183685
Pubmed	LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.	BRSK2 BRSK1	1.48e-04	15	42	2	14976552
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	MACF1 HDAC5 CLCN6 UNC80	1.57e-04	225	42	4	12168954
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	TNNI1 TNNI2	1.69e-04	16	42	2	16494860
Pubmed	HIC2 regulates isoform switching during maturation of the cardiovascular system.	TNNI1 TNNI2	1.69e-04	16	42	2	29061339
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	TNNI1 TNNI2	1.69e-04	16	42	2	19922871
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	KIF18A RPL27A FGD5 CD2AP RAD17 ASH1L	1.69e-04	689	42	6	36543142
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	TNNI1 TNNI2	1.91e-04	17	42	2	16124007
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	ATXN2L MACF1 RPL27A ZC3H18 MAGT1 CD2AP	1.96e-04	708	42	6	39231216
Pubmed	Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.	ACTN2 TNNI1	2.40e-04	19	42	2	29374072
Pubmed	LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.	BRSK2 BRSK1	2.40e-04	19	42	2	17482548
Pubmed	Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis.	TNNI1 TNNI2	2.67e-04	20	42	2	22267199
Pubmed	Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.	BRSK2 BRSK1	2.67e-04	20	42	2	18227155
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	KIF18A MAGT1 TNNI1 C3orf20 CTSC RAD17	2.67e-04	750	42	6	11230166
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	LRRC37A HDAC5 LRRC37A3	2.82e-04	105	42	3	9628581
Pubmed	Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c.	TNNI1 TNNI2	2.95e-04	21	42	2	17875930
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	TNNI1 TNNI2	3.24e-04	22	42	2	24301466
Pubmed	SAD kinases sculpt axonal arbors of sensory neurons through long- and short-term responses to neurotrophin signals.	BRSK2 BRSK1	3.54e-04	23	42	2	23790753
Pubmed	Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.	TNNI1 TNNI2	3.54e-04	23	42	2	25190801
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	MACF1 ACTN2 CD2AP	4.17e-04	120	42	3	31413325
Pubmed	Screening the proteins that interact with calpain in a human heart cDNA library using a yeast two-hybrid system.	ACTN2 CTSC	4.20e-04	25	42	2	12358155
Pubmed	Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans.	ACTN2 TNNI1	4.54e-04	26	42	2	30121012
Pubmed	Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.	MACF1 ACTN2 TNNI2	5.63e-04	133	42	3	15604093
Pubmed	HAND2-mediated epithelial maintenance and integrity in cardiac outflow tract morphogenesis.	ACTN2 TNNI2	5.66e-04	29	42	2	31201155
Pubmed	14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.	BRSK2 BRSK1	6.06e-04	30	42	2	16306228
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	HDAC5 ASH1L	6.06e-04	30	42	2	17403666
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	TNNI1 TNNI2	6.47e-04	31	42	2	21985497
Pubmed	Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.	TNNI1 TNNI2	6.47e-04	31	42	2	16140986
Pubmed	STK11 is required for the normal program of ciliated cell differentiation in airways.	BRSK2 BRSK1	6.47e-04	31	42	2	31636950
Pubmed	Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.	TNNI1 TNNI2	6.90e-04	32	42	2	19320717
Pubmed	Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle.	ACTN2 TNNI2	6.90e-04	32	42	2	17904117
Pubmed	Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation.	BCL9L MACF1 RPL27A	8.29e-04	152	42	3	34299191
Pubmed	Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.	ACTN2 TNNI1	9.74e-04	38	42	2	38196272
Pubmed	Roles of tau protein in health and disease.	BRSK2 BRSK1	1.08e-03	40	42	2	28386764
Pubmed	Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.	TNNI1 TNNI2	1.13e-03	41	42	2	18157088
Cytoband	Ensembl 112 genes in cytogenetic band chr3p25	FGD5 IL17RE C3orf20	4.22e-04	155	43	3	chr3p25
Cytoband	3p25.1	FGD5 C3orf20	5.00e-04	35	43	2	3p25.1
Cytoband	Xq25	TEX13D APLN	6.87e-04	41	43	2	Xq25
GeneFamily	EF-hand domain containing\|Troponin complex subunits	TNNI1 TNNI2	4.71e-05	8	24	2	1219
Drug	AC1NUV13	TNNI1 TNNI2	9.48e-06	3	41	2	CID005494391
Drug	diethyl sebacate	CTSC CD2AP	1.89e-05	4	41	2	CID000008049
Disease	serine/threonine-protein kinase BRSK2 measurement	BRSK2 BRSK1	5.65e-06	3	41	2	EFO_0803063
Disease	adenocarcinoma (implicated_via_orthology)	TNNI1 TNNI2	3.94e-05	7	41	2	DOID:299 (implicated_via_orthology)
Disease	corpus callosum mid-anterior volume measurement	BRSK2 OSTN	6.47e-04	27	41	2	EFO_0010297
Disease	heart disease (implicated_via_orthology)	TNNI1 TNNI2	1.28e-03	38	41	2	DOID:114 (implicated_via_orthology)
Disease	clinical treatment	ADCY7 CTSC	1.49e-03	41	41	2	EFO_0007056
Disease	brain connectivity measurement	BRSK2 OSTN CTSC LRRC37A2	2.27e-03	400	41	4	EFO_0005210
Disease	pulmonary hypertension (is_marker_for)	HDAC5 APLN	3.60e-03	64	41	2	DOID:6432 (is_marker_for)
Disease	autoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis	ATXN2L ADCY7	4.29e-03	70	41	2	EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Disease	cardiomyopathy (implicated_via_orthology)	TNNI1 TNNI2	4.41e-03	71	41	2	DOID:0050700 (implicated_via_orthology)
Disease	dilated cardiomyopathy (implicated_via_orthology)	TNNI1 TNNI2	5.56e-03	80	41	2	DOID:12930 (implicated_via_orthology)
Disease	thalamus volume	OSTN MACF1	6.25e-03	85	41	2	EFO_0006935

Protein segments in the cluster

Peptide	Gene	Start	Entry
FPKKRGRPKRQMRSP	ASH1L	886	Q9NR48
GERLPKPDRGKMRFH	ACTN2	81	P35609
RSKRTPLPRKRQLMH	C8orf33	146	Q9H7E9
AKRKHRRLRFPPMDT	FAM47DP	31	A6NHR8
KFRRQRPRLSHKGPM	APLN	61	Q9ULZ1
LLHLTANRPKMPGRR	CD2AP	486	Q9Y5K6
HLPRPKGDAALKMRA	ADCY7	466	P51828
RQPSRRKPMDDHLRK	CEP20	141	Q96NB1
GTRLPPKTHRKMARK	ATXN7L2	221	Q5T6C5
SRMSPKAQRPLRGAK	ATXN2L	406	Q8WWM7
RLPLKRHFGRLKMEA	RAD17	586	O75943
RAGIKRMRAQLPHVK	FBXL2	381	Q9UKC9
RVLMGPRSIQKRHFK	LRRC37A3	1166	O60309
MNGDKFRRLVKAPPR	MAGT1	56	Q9H0U3
RVLMGPRSIQKRHFK	LRRC37A2	1166	A6NM11
RVLMGPRSIQKRHFK	LRRC37A	1166	A6NMS7
MAPRSRRRRHKKPPS	MSS51	1	Q4VC12
RTRRKLMPSPLKGQH	KIF18A	666	Q8NI77
RSRSKLMAPPRIGTH	MYG1	36	Q9HB07
KMPAPAQRKLLPRRH	IL17RE	116	Q8NFR9
PRKRVDSPMLNRHGK	BRSK2	361	Q8IWQ3
MKVTGKNRRPRHLFL	FGD5	1121	Q6ZNL6
AGMVHRLLKRTPRPA	GPR78	306	Q96P69
GIKLPREKGRMRFHR	MACF1	121	Q9UPN3
HPKRRFGIPMDRIGR	OSTN	111	P61366
VEFHKMGSFRRPRPR	PRR5L	11	Q6MZQ0
KRLAKYRMRNVHPKP	CLCN6	356	P51797
RFKMRSRTHPERLPK	C3orf20	581	Q8ND61
MRILANKTRLPHPRR	BCL9L	1	Q86UU0
KRCMEIFGPRHRRPR	GJB4	211	Q9NTQ9
MIRRSGGHSRKIPRP	CTSC	201	P53634
RVDSPMLSRHGKRRP	BRSK1	381	Q8TDC3
LGSPRFHRRKMQVPT	BRSK1	561	Q8TDC3
MRTVGKLPRHRPLSR	HDAC5	481	Q9UQL6
GLPMFSRDNKPRRIH	FADS6	251	Q8N9I5
MPSRLRKTRKLRGHV	RPL27A	1	P46776
RRKRRHHKSPMLNLF	GLRA1	346	P23415
KFKRPPLRRVRMSAD	TNNI2	106	P48788
GPKRARRMHTLVFRR	TEX13D	376	A0A0J9YY54
QRTPFPMRRLHKRKQ	ZBTB5	181	O15062
KRRPRRMGVPFLLHE	UNC80	466	Q8N2C7
VMDLRGKFKRPPLRR	TNNI1	101	P19237
GPGEMRRARKRKHTI	ZCCHC12	331	Q6PEW1
RKVRPRPTCRFFMKG	ZC3H18	216	Q86VM9