Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

TH PAH

1.49e-047542GO:0016714
GeneOntologyBiologicalProcesscatechol-containing compound biosynthetic process

TH MOXD1 PAH EPAS1

8.14e-0729524GO:0009713
GeneOntologyBiologicalProcesscatecholamine biosynthetic process

TH MOXD1 PAH EPAS1

8.14e-0729524GO:0042423
GeneOntologyBiologicalProcessnorepinephrine biosynthetic process

TH MOXD1 EPAS1

1.79e-0610523GO:0042421
GeneOntologyBiologicalProcessbiogenic amine biosynthetic process

TH MOXD1 PAH EPAS1

5.91e-0647524GO:0042401
GeneOntologyBiologicalProcessamine biosynthetic process

TH MOXD1 PAH EPAS1

6.44e-0648524GO:0009309
GeneOntologyBiologicalProcessembryonic organ development

A2M IFT140 TH TRIOBP KMT2A COBL EPAS1 RYR2 PCNT

9.91e-06561529GO:0048568
GeneOntologyBiologicalProcessphenol-containing compound biosynthetic process

TH MOXD1 PAH EPAS1

1.29e-0557524GO:0046189
GeneOntologyBiologicalProcessnorepinephrine metabolic process

TH MOXD1 EPAS1

1.95e-0521523GO:0042415
GeneOntologyBiologicalProcesscatechol-containing compound metabolic process

TH MOXD1 PAH EPAS1

3.63e-0574524GO:0009712
GeneOntologyBiologicalProcesscatecholamine metabolic process

TH MOXD1 PAH EPAS1

3.63e-0574524GO:0006584
GeneOntologyBiologicalProcessneuroligin clustering involved in postsynaptic membrane assembly

MAGI2 NRXN2

3.73e-054522GO:0097118
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

MAGI2 ARHGAP32 SEMA7A LRP1 COBL ULK2

1.03e-04299526GO:0060560
GeneOntologyBiologicalProcesscollateral sprouting

LRP1 COBL ULK2

1.11e-0437523GO:0048668
GeneOntologyBiologicalProcessnegative regulation of cell-matrix adhesion

LRP1 BCL6 SEMA3E

1.74e-0443523GO:0001953
GeneOntologyBiologicalProcessbiogenic amine metabolic process

TH MOXD1 PAH EPAS1

2.45e-04121524GO:0006576
GeneOntologyBiologicalProcessregulation of extent of cell growth

ARHGAP32 SEMA7A LRP1 ULK2

2.53e-04122524GO:0061387
GeneOntologyBiologicalProcessdopamine metabolic process

TH MOXD1 EPAS1

3.24e-0453523GO:0042417
GeneOntologyBiologicalProcesspostsynaptic membrane assembly

MAGI2 NRXN2

3.38e-0411522GO:0097104
GeneOntologyBiologicalProcesszinc ion import across plasma membrane

SLC39A6 SLC39A14

3.38e-0411522GO:0071578
GeneOntologyBiologicalProcesspositive regulation of axon extension

ARHGAP32 SEMA7A LRP1

3.61e-0455523GO:0045773
GeneOntologyBiologicalProcessaxon extension

ARHGAP32 SEMA7A LRP1 ULK2

3.72e-04135524GO:0048675
GeneOntologyBiologicalProcessmanganese ion transmembrane transport

SLC39A14 RYR2

4.05e-0412522GO:0071421
GeneOntologyBiologicalProcessphenol-containing compound metabolic process

TH MOXD1 PAH EPAS1

4.51e-04142524GO:0018958
GeneOntologyBiologicalProcessamine metabolic process

TH MOXD1 PAH EPAS1

5.27e-04148524GO:0009308
GeneOntologyBiologicalProcessmanganese ion transport

SLC39A14 RYR2

5.56e-0414522GO:0006828
MousePhenofetal cardiomyocyte vacuoles

TH RYR2

6.05e-054452MP:0031614
MousePhenoheart vascular congestion

TH EPAS1

6.05e-054452MP:0010021
MousePhenodecreased noradrenaline level

TH PAH EPAS1

6.82e-0525453MP:0012574
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

4.93e-0612543PF15371
DomainDUF4599

SPATA31A3 SPATA31A7 SPATA31A5

4.93e-0612543IPR027970
DomainGABBAg_rcpt

GABRG1 GABRG3

2.46e-053542IPR005437
DomainBiopterin_H

TH PAH

4.90e-054542PF00351
Domain-

TH PAH

4.90e-0545421.10.800.10
DomainTyrosine_3-monooxygenase-like

TH PAH

4.90e-054542IPR019773
DomainAromatic-AA_hydroxylase_C

TH PAH

4.90e-054542IPR019774
DomainArAA_hydroxylase_Fe/CU_BS

TH PAH

4.90e-054542IPR018301
DomainBH4_AAA_HYDROXYL_2

TH PAH

4.90e-054542PS51410
DomainArAA_hydroxylase

TH PAH

4.90e-054542IPR001273
DomainBH4_AAA_HYDROXYL_1

TH PAH

4.90e-054542PS00367
DomainZip

SLC39A6 SLC39A14

7.30e-0414542PF02535
DomainZIP

SLC39A6 SLC39A14

7.30e-0414542IPR003689
DomainSemaphorin

SEMA7A SEMA3E

1.51e-0320542IPR027231
DomainPAS_fold_3

EPAS1 KCNH3

2.00e-0323542IPR013655
DomainPAS_3

EPAS1 KCNH3

2.00e-0323542PF08447
DomainGABAA/Glycine_rcpt

GABRG1 GABRG3

2.00e-0323542IPR006028
DomainPAS-assoc_C

EPAS1 KCNH3

2.17e-0324542IPR000700
DomainPAC

EPAS1 KCNH3

2.55e-0326542IPR001610
DomainPAC

EPAS1 KCNH3

2.55e-0326542SM00086
DomainPAC

EPAS1 KCNH3

2.55e-0326542PS50113
DomainSema

SEMA7A SEMA3E

3.62e-0331542SM00630
DomainSemap_dom

SEMA7A SEMA3E

3.62e-0331542IPR001627
DomainSema

SEMA7A SEMA3E

3.62e-0331542PF01403
DomainSEMA

SEMA7A SEMA3E

3.62e-0331542PS51004
DomainPAS

EPAS1 KCNH3

3.85e-0332542SM00091
DomainPH

PRKD3 OSBPL10 TRIOBP CYTH4

4.31e-03229544PF00169
DomainPAS

EPAS1 KCNH3

4.34e-0334542IPR000014
DomainPAS

EPAS1 KCNH3

4.34e-0334542PS50112
DomainEGF

SELP NRXN2 LRP1

5.79e-03126543PF00008
DomainPSI

SEMA7A SEMA3E

7.18e-0344542IPR016201
DomainNeurotransmitter_ion_chnl_CS

GABRG1 GABRG3

7.50e-0345542IPR018000
DomainNeur_chan_memb

GABRG1 GABRG3

7.83e-0346542PF02932
DomainPSI

SEMA7A SEMA3E

7.83e-0346542SM00423
DomainNeur_chan_LBD

GABRG1 GABRG3

8.16e-0347542PF02931
DomainNEUROTR_ION_CHANNEL

GABRG1 GABRG3

8.16e-0347542PS00236
DomainNeurotrans-gated_channel_TM

GABRG1 GABRG3

8.16e-0347542IPR006029
Domain-

GABRG1 GABRG3

8.16e-03475422.70.170.10
DomainNeur_channel

GABRG1 GABRG3

8.16e-0347542IPR006201
DomainNeur_chan_lig-bd

GABRG1 GABRG3

8.16e-0347542IPR006202
DomainPH

PRKD3 OSBPL10 TRIOBP CYTH4

8.48e-03278544SM00233
Domain-

PIR KCNH3

8.50e-03485422.60.120.10
DomainPH_DOMAIN

PRKD3 OSBPL10 TRIOBP CYTH4

8.58e-03279544PS50003
PathwayREACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY

SLC39A6 SLC39A14

2.40e-048422MM15106
PathwayREACTOME_ZINC_INFLUX_INTO_CELLS_BY_THE_SLC39_GENE_FAMILY

SLC39A6 SLC39A14

3.84e-0410422M27361
PathwayREACTOME_ZINC_TRANSPORTERS

SLC39A6 SLC39A14

4.69e-0411422MM15101
PathwayREACTOME_OTHER_SEMAPHORIN_INTERACTIONS

SEMA7A SEMA3E

7.71e-0414422MM15047
PathwayWP_BIOGENIC_AMINE_SYNTHESIS

TH PAH

8.88e-0415422M39705
PathwayWP_BIOGENIC_AMINE_SYNTHESIS

TH PAH

8.88e-0415422MM15857
PathwayWP_BIOSYNTHESIS_AND_REGENERATION_OF_TETRAHYDROBIOPTERIN_AND_CATABOLISM_OF_PHENYLALANINE

TH PAH

8.88e-0415422M45537
PathwayREACTOME_ZINC_TRANSPORTERS

SLC39A6 SLC39A14

8.88e-0415422M832
Pubmed

The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.

SPATA31A3 SPATA31A7 SPATA31A5

7.05e-08654320850414
Pubmed

Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.

SPATA31A3 SPATA31A7 SPATA31A5

7.05e-08654325930072
Pubmed

Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways.

TH PAH

2.37e-0625422872999
Pubmed

NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)-macroglobulin.

A2M LRP1

2.37e-06254210652313
Pubmed

Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.

SLC39A6 SLC39A14

2.37e-06254215642354
Pubmed

Association of polymorphisms in the LRP1 and A2M genes with Alzheimer's disease in the northern Chinese Han population.

A2M LRP1

2.37e-06254223186781
Pubmed

Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia.

KMT2A BCL6

2.37e-06254231395741
Pubmed

Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling.

A2M LRP1

2.37e-06254220048078
Pubmed

Hypoxia inducible factor-2α importance for migration, proliferation, and self-renewal of trunk neural crest cells.

TH EPAS1

2.37e-06254232940375
Pubmed

Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.

A2M LRP1

2.37e-06254211823454
Pubmed

α-2-Macroglobulin induces the shedding of microvesicles from cutaneous wound myofibroblasts.

A2M LRP1

2.37e-06254230479021
Pubmed

Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.

A2M LRP1

2.37e-0625428485155
Pubmed

Association study of the A2M and LRP1 Genes with Alzheimer disease in the Han Chinese.

A2M LRP1

2.37e-06254216040006
Pubmed

Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species.

SPATA31A3 SPATA31A7 SPATA31A5

7.00e-062454332212159
Pubmed

Involvement of alpha-2-macroglobulin receptor in clearance of interleukin 8-alpha-2-macroglobulin complexes by human alveolar macrophages.

A2M LRP1

7.09e-06354210880251
Pubmed

Different stabilities and denaturation pathways for structurally related aromatic amino acid hydroxylases.

TH PAH

7.09e-06354215135070
Pubmed

Activated α(2) macroglobulin induces matrix metalloproteinase 9 expression by low-density lipoprotein receptor-related protein 1 through MAPK-ERK1/2 and NF-κB activation in macrophage-derived cell lines.

A2M LRP1

7.09e-06354220568116
Pubmed

An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression.

GABRG1 GABRG3

7.09e-06354219019179
Pubmed

Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes.

A2M LRP1

7.09e-06354216402284
Pubmed

The role of Grp 78 in alpha 2-macroglobulin-induced signal transduction. Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, GRP 78-mediated signal transduction.

A2M LRP1

7.09e-06354212194978
Pubmed

Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction.

A2M LRP1

7.09e-06354212394648
Pubmed

Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.

SELP LRP1

1.42e-05454215769472
Pubmed

Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.

GABRG1 GABRG3

1.42e-05454211948245
Pubmed

Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.

A2M LRP1

1.42e-05454218706476
Pubmed

Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.

KMT2A EPAS1

1.42e-05454226642852
Pubmed

Abnormal expression of genes associated with development and inflammation in the heart of mouse maternal phenylketonuria offspring.

PAH RYR2

1.42e-05454216164837
Pubmed

C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene.

CEBPE KMT2A

1.42e-05454218776924
Pubmed

Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.

A2M LRP1

1.42e-05454220637261
Pubmed

Acute O2 sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.

TH EPAS1

1.42e-05454231848220
Pubmed

Crosstalk between leukemia-associated proteins MOZ and MLL regulates HOX gene expression in human cord blood CD34+ cells.

MOXD1 KMT2A

2.36e-05554220581860
Pubmed

Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues.

A2M LRP1

2.36e-0555427514554
Pubmed

Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.

A2M LRP1

2.36e-05554211100124
Pubmed

The Chromatin Regulator Mll1 Supports T Follicular Helper Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1.

KMT2A BCL6

2.36e-05554237074193
Pubmed

HIF-2α is essential for carotid body development and function.

TH EPAS1

3.54e-05654229671738
Pubmed

Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.

KMT2A BCL6

3.54e-05654225759025
Pubmed

Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.

A2M LRP1

3.54e-05654215389876
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

MAGI2 UBR2 COBL SLC39A14 ULK2 PCNT

3.98e-0540754612693553
Pubmed

Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.

A2M LRP1

4.94e-05754215226301
Pubmed

Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism.

GABRG1 GABRG3

4.94e-05754216080114
Pubmed

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

A2M LRP1

4.94e-05754217920016
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

MAGI2 IFT140 ARHGAP32 NRXN2

5.10e-0513054412421765
Pubmed

The LZT proteins; the LIV-1 subfamily of zinc transporters.

SLC39A6 SLC39A14

6.59e-05854212659941
Pubmed

Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation.

TH SEMA7A

6.59e-05854229038581
Pubmed

ACE variants and risk of intracerebral hemorrhage recurrence in amyloid angiopathy.

A2M LRP1

6.59e-05854220381197
Pubmed

Examination of tetrahydrobiopterin pathway genes in autism.

TH PAH

8.46e-05954219674121
Pubmed

Targeted inactivation of the mouse alpha 2-macroglobulin gene.

A2M LRP1

8.46e-0595427544347
Pubmed

Examination of association to autism of common genetic variationin genes related to dopamine.

TH PAH

8.46e-05954219360691
Pubmed

The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.

COBL PCNT

8.46e-05954230157434
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

GABRG1 MAGI2 GABRG3 NRXN2 PAH

1.03e-0430054519086053
Pubmed

Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder.

GABRG1 GABRG3

1.06e-041054220583128
Pubmed

USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer.

GABRG3 PAH BCL6

1.14e-046054336607699
Pubmed

An investigation into the human serum "interactome".

SPATA31A7 PLAG1 RYR2 PDZRN4

1.20e-0416254415174051
Pubmed

γ1 GABAA Receptors in Spinal Nociceptive Circuits.

GABRG1 GABRG3

1.29e-041154239137998
Pubmed

An association analysis of Alzheimer disease candidate genes detects an ancestral risk haplotype clade in ACE and putative multilocus association between ACE, A2M, and LRRTM3.

A2M LRP1

1.29e-041154219105203
Pubmed

The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.

TH RYR2

1.29e-041154227217161
Pubmed

Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.

TH SEMA3E

1.55e-041254219812329
Pubmed

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program.

CEBPE KMT2A

1.55e-041254227462455
Pubmed

Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex.

TH MOXD1

1.83e-041354219008461
Pubmed

Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.

CEBPE BCL6

1.83e-041354227133822
Pubmed

Association study of 182 candidate genes in anorexia nervosa.

GABRG1 GABRG3 TH PAH

1.87e-0418254420468064
Pubmed

Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification.

TH KMT2A RYR2

2.39e-047754329445148
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

ACADVL MMRN2 TRIOBP PCNT EHD2

2.41e-0436054533111431
Pubmed

Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.

A2M LRP1

2.45e-041554211436125
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

THADA SEMA7A COBL TEP1 ULK2 CYTH4 KCNH3 PCNT

2.88e-04110554835748872
Pubmed

Functional proteomics mapping of a human signaling pathway.

A2M LRP1 PLAG1 PIR EPAS1 RYR2

3.03e-0459154615231748
Pubmed

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

GABRG1 GABRG3

3.56e-041854219078961
Pubmed

GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality.

GABRG1 GABRG3

3.56e-041854218985723
Pubmed

Frizzled3 Controls Axonal Polarity and Intermediate Target Entry during Striatal Pathway Development.

TH SEMA3E

3.98e-041954226490861
Pubmed

Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage.

SEMA7A SEMA3E

3.98e-041954215051154
Pubmed

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

TH THADA

3.98e-041954219767753
Pubmed

Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.

TH PCNT

4.42e-042054219439492
Pubmed

Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.

TH THADA

4.42e-042054220564319
Pubmed

Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity.

SEMA7A SEMA3E

4.88e-042154236240771
Pubmed

A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.

TNNI2 EPAS1

4.88e-042154225340332
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

ARHGAP32 OSBPL10 TRIOBP SLC39A6 COBL

4.93e-0442154536976175
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

MAGI2 COBL ULK2

5.45e-041025439734811
Pubmed

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

MOXD1 SLC39A14 SEMA3E

5.93e-0410554324667918
Pubmed

A semaphorin code defines subpopulations of spinal motor neurons during mouse development.

SEMA7A SEMA3E

6.39e-042454215869472
Pubmed

Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.

SEMA7A SEMA3E

8.72e-042854218617019
Pubmed

Developmental gene expression profiling along the tonotopic axis of the mouse cochlea.

A2M PDZRN4

8.72e-042854222808246
Pubmed

Alternatively spliced isoforms of WT1 control podocyte-specific gene expression.

MAGI2 SEMA3E

8.72e-042854225993318
Pubmed

Noggin is required for correct guidance of dorsal root ganglion axons.

SEMA7A SEMA3E

9.35e-042954212435358
Pubmed

Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.

GABRG1 TH

9.35e-042954237192624
Pubmed

The essential player in adipogenesis GRP78 is a novel KCTD15 interactor.

A2M EHD2

9.35e-042954229665387
Pubmed

Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.

ZNF91 ZNF679

9.35e-042954214563677
Pubmed

Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.

TH LRP1

1.07e-033154219796621
Pubmed

Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.

GABRG1 GABRG3

1.07e-033154219736351
Pubmed

Dissection of behavior and psychiatric disorders using the mouse as a model.

TH PAH

1.07e-033154210767319
Pubmed

Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.

TH SEMA3E

1.21e-033354218199763
Pubmed

Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.

MAGI2 PDZRN4

1.29e-033454230726710
Pubmed

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.

TH SEMA7A

1.36e-033554222407321
Pubmed

A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.

TH TNNI2

1.36e-033554223936387
Pubmed

Quantifying domain-ligand affinities and specificities by high-throughput holdup assay.

MAGI2 PDZRN4

1.44e-033654226053890
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

SEMA7A TRIOBP COBL

1.45e-0314354332560809
Pubmed

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.

NRXN2 BCL6

1.52e-033754222797727
Pubmed

Heart neurons use clock genes to control myocyte proliferation.

TH RYR2

1.52e-033754234851661
CytobandEnsembl 112 genes in cytogenetic band chr9q12

SPATA31A7 SPATA31A5

3.79e-058542chr9q12
GeneFamilyGamma-aminobutyric acid type A receptor subunits

GABRG1 GABRG3

6.82e-0419372563
GeneFamilyImmunoglobulin like domain containing|Semaphorins

SEMA7A SEMA3E

7.56e-0420372736
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PRKD3 OSBPL10 TRIOBP CYTH4

8.05e-04206374682
CoexpressionAIZARANI_LIVER_C30_HEPATOCYTES_4

A2M MACC1 ACADVL PAH UTP23 BCL6 SLC39A14 CMC2 SEMA3E

2.52e-07446539M39129
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

A2M UTP23 ZNF91 TNNI2 RYR2 SEMA3E PCNT

2.86e-06309537MM1244
CoexpressionYAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN

A2M UTP23 TNNI2 RYR2 SEMA3E PCNT

1.37e-05259536M9331
CoexpressionAIZARANI_LIVER_C29_MVECS_2

A2M SELP MMRN2 TRIOBP EPAS1 EHD2

3.96e-05313536M39128
CoexpressionHOEBEKE_LYMPHOID_STEM_CELL_UP

UBR2 COBL BCL6 CYTH4

4.49e-0597534M14698
CoexpressionGSE13522_CTRL_VS_T_CRUZI_BRAZIL_STRAIN_INF_SKIN_DN

GABRG3 LRP1 BCL6 TEP1 PDZRN4

5.12e-05199535M2921
CoexpressionGSE4748_CTRL_VS_LPS_AND_CYANOBACTERIUM_LPSLIKE_STIM_DC_3H_DN

RNF214 ACADVL ULK2 SEMA3E EHD2

5.24e-05200535M6485
CoexpressionGSE30971_2H_VS_4H_LPS_STIM_MACROPHAGE_WBP7_KO_UP

PRKD3 SELP GABRG1 RYR2 MGME1

5.24e-05200535M8703
CoexpressionWONG_ADULT_TISSUE_STEM_MODULE

SELP GABRG1 MAGI2 ARHGAP32 MOXD1 KMT2A RYR2 SEMA3E

9.36e-05721538M1999
CoexpressionPOMEROY_MEDULLOBLASTOMA_PROGNOSIS_UP

ACADVL BRME1 KMT2A

1.27e-0448533M18328
CoexpressionPARENT_MTOR_SIGNALING_UP

IFT140 THADA LRP1 TRIOBP PLAG1 CYTH4 EHD2

1.39e-04567537M16909
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRG1 GABRG3 EPAS1 RYR2 EHD2 PDZRN4

1.04e-0718754648bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRG1 GABRG3 EPAS1 RYR2 EHD2 PDZRN4

1.04e-07187546958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRG1 GABRG3 EPAS1 RYR2 EHD2 PDZRN4

1.11e-07189546fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCelldroplet-Liver-Hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP ARHGAP32 NRXN2 MMRN2 EPAS1 EHD2

1.11e-07189546ce5b3d53c9a5457a5a02b221dee18334b5eaf8b7
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ACADVL LRP1 BCL6 SLC39A14 EPAS1 EHD2

1.50e-0719954685bb28369e0568b7b3bda095722102fc793f60ef
ToppCellmedial-Endothelial-Vein-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1 PDZRN4

1.55e-072005463f689029f5bc7db0af50a405f1e252aeec529077
ToppCelldistal-2-Endothelial-Vein|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1 PDZRN4

1.55e-072005462785225956d2422acab90e99b7debe3709cf3308
ToppCellmedial-Endothelial-Vein|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1 PDZRN4

1.55e-072005461163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCelldistal-Endothelial-Vein|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1 PDZRN4

1.55e-072005466acf7afe122f81a95c4c66f4d0878d997b57127a
ToppCellmedial-2-Endothelial-Vein|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1 PDZRN4

1.55e-0720054649da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP MOXD1 MMRN2 PIR EPAS1

1.92e-0616954558136b8a0bf2dab45c91a053ef7225ea49ccb871
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP MOXD1 MMRN2 PIR EPAS1

1.92e-0616954504c6ed38e1d1befba5ef5f37a3c1e045a0b163d6
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 PIR EPAS1

2.76e-06182545d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 PIR EPAS1

3.15e-06187545d6765854154557794815514c0aa355bc74b8523e
ToppCelldroplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.24e-0618854567c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCelldroplet-Kidney-nan-3m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.24e-0618854503a7f6538cfddc230c0eab10c3613929addd7e33
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.32e-061895452ce330d8078833c05775c481e73770f9ee4a5c88
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP SEMA7A MMRN2 EPAS1 EHD2

3.32e-06189545a3f6ebd1622d36d114e42f6e0618d7b2fe8b9a2f
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP SEMA7A MMRN2 EPAS1 EHD2

3.32e-06189545d86455cf20769d70d62e2c1dd92cbc93c67aada5
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MOXD1 SEMA7A MMRN2 EPAS1 EHD2

3.32e-06189545feedac2751ed770f80bc56fec31662b5b3826f58
ToppCellE17.5-Endothelial-large_vessel_endothelial_cell|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MOXD1 SEMA7A MMRN2 EPAS1 EHD2

3.32e-06189545360f09f46231a83f99d8fa0158b72a38068e1642
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.32e-06189545473c87036e04a058b4a5138438b7ba7e1e766799
ToppCelldroplet-Limb_Muscle-nan-18m-Endothelial-endothelial_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELP SEMA7A MMRN2 EPAS1 EHD2

3.32e-0618954584036d1257f6b18f47cfc7ac5e6ed6ea3553c235
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.41e-06190545cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.41e-061905455bf3d0beee69879c95265d07fba023626a7cc808
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 EPAS1 EHD2

3.41e-06190545141266bf411ea675fbf889b20c1b08673c45ff95
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.59e-06192545144503af50274eaed5cf6effa892c640eab28663
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEMA7A MMRN2 PIR EPAS1 EHD2

3.59e-06192545c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M SELP MMRN2 SLC39A14 EPAS1

3.68e-06193545c0f0052c24b7fe9e21d2bc6c38047a8e755f87b6
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M SELP MMRN2 SLC39A14 EPAS1

3.68e-06193545682ce63b73a7d02eef240673db67058d7507f744
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2|World / Primary Cells by Cluster

GABRG1 GABRG3 NRXN2 COBL PDZRN4

3.77e-06194545b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2-10|World / Primary Cells by Cluster

GABRG1 GABRG3 NRXN2 COBL PDZRN4

3.77e-0619454581e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCellEndothelial-A-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

A2M SELP MMRN2 SLC39A14 EPAS1

3.87e-06195545c3a0aa34b672c99cb3a2a4e9218412dbd19da3ca
ToppCell3'-Distal_airway-Endothelial-Blood_vessel_EC-vein_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M SELP MMRN2 SLC39A14 EPAS1

3.87e-0619554553b83e16b350100b1d5791a9c42bd98e37cbc0af
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 PIR EPAS1

4.06e-0619754587eda06344498dc66cac292cf89746dc90b5cf67
ToppCelldistal-Endothelial-Vein-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 EPAS1 PDZRN4

4.06e-061975453d71c93da4b88ebbd58e68ed3dbf610d4bcfc4f5
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M SELP MMRN2 PIR EPAS1

4.06e-061975458437c33e2c4a10a1b95343431e48d5e820b1f742
ToppCelldistal-Endothelial-Artery-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 PIR EPAS1

4.17e-06198545f284f59f4ebe55ee132eddfaa2f5d9ecb059654f
ToppCellTracheal-10x5prime-Stromal-Chondrocytic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

A2M MOXD1 LRP1 SLC39A14 PDZRN4

4.17e-06198545c72ef2ddcbb6dacbed4c6200d89e17d57314dcdc
ToppCellLAM-Endothelial-VasEndo-2|Endothelial / Condition, Lineage and Cell class

A2M SELP MMRN2 PIR EPAS1

4.17e-0619854592bccaec01f1dbb17d5efcba30f7f800f674ca96
ToppCelldistal-1-Endothelial-Vein|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 EPAS1 PDZRN4

4.17e-06198545eee6cb4fe0e1caf460869d5a0a57c9d259573f10
ToppCellTracheal-10x5prime-Stromal-Chondrocytic-Chondrocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

A2M MOXD1 LRP1 SLC39A14 PDZRN4

4.17e-0619854555f013e9e6587d9ece59751fa131b1d22d6cceea
ToppCellILEUM-inflamed-(7)_ACKR1+_endothelial_cells|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

A2M SELP MMRN2 EPAS1 EHD2

4.27e-061995455c799115a6e95bcd896e4ad10bd272705c9a4e2c
ToppCell5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 PIR EPAS1

4.27e-06199545a8f2eb00c3e4267a174bc9eff307dc2e5d18c76e
ToppCelldistal-Endothelial-Vein-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 EPAS1 PDZRN4

4.27e-06199545f9fc0482d7ab11f2165b30cce3564b4ff87d61a6
ToppCelldistal-Endothelial-Artery|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 PIR EPAS1

4.27e-06199545b6e9aaac047d4b64b9d97f5e174e89a424d8b36d
ToppCelldistal-1-Endothelial-Artery|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 PIR EPAS1

4.27e-06199545fd71d08f6de790a29c880d50d2ed0881952d7791
ToppCelldistal-Endothelial-Artery-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 PIR EPAS1

4.27e-061995458acf381087268fcf13f025e3b67e028bf1f9b77e
ToppCelldistal-2-Endothelial-Artery|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 PIR EPAS1

4.27e-06199545fa8aaf7a90699e41a7a4cee5614f8c9248110327
ToppCellBronchial-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M MOXD1 LRP1 RYR2 PDZRN4

4.37e-06200545389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCelldistal-3-Endothelial-Vein|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 EPAS1 PDZRN4

4.37e-062005453a5c85bad2e7a9ecf55d90acb04178a343b3f5fd
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_pulmonary_arterial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

A2M SELP MMRN2 PIR EPAS1

4.37e-06200545e90ca26643f8496bdd6672c327da9855490d1aa8
ToppCelldistal-Endothelial-Vein-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

A2M SELP MMRN2 SLC39A14 EPAS1

4.37e-06200545ff88d28162e0231d5dac0e0c6bec98fa8da58a23
ToppCell5'-Adult-SmallIntestine-Endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M SELP MMRN2 EPAS1 EHD2

4.37e-062005452554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MAGI2 TH SEMA7A PDZRN4

2.18e-051355445113bb1713f99d01103b9a99de5d80393081cf87
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 SEMA3E EHD2 PDZRN4

3.47e-05152544bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

RYR2 SEMA3E EHD2 PDZRN4

3.47e-05152544ee329249a034a969a16b26a224aa04249d67382d
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SELP MACC1 ACADVL TRIOBP

3.65e-051545441f8d127b657976656e4ec292f26d619943533b86
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4/8-lo-Trm_Tgd|lymph-node_spleen / Manually curated celltypes from each tissue

SEMA7A ZNF91 TEP1 EPAS1

3.75e-05155544b0e456c4915076e1d38282e116a6eb3230ae80dc
ToppCellPND07-28-samps-Mesenchymal-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SELP MAGI2 OSBPL10 RYR2

3.84e-05156544574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCellPND07-28-samps-Mesenchymal-Mesothelial-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SELP MAGI2 OSBPL10 RYR2

3.84e-05156544605d95a900e1443d3f6aae163ef2e893d3293203
ToppCellPND10-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

BRME1 BCL6 TNNI2 CYTH4

4.14e-05159544807ee55fe0d3645fbfb98f641dd0a0555b847cf5
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MAGI2 MOXD1 CCDC62 PDZRN4

5.25e-0516954458e22f9119240664515fe91ca53812611a8f17d6
ToppCellE16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THADA SEMA7A MMRN2 EPAS1

5.37e-0517054455fe16d98ea284d05fb899888e4569c685644c7b
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MOXD1 MMRN2 TRIOBP EHD2

5.49e-051715443112d15f2a28cf4a71992db4971d960716dc1264
ToppCell10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages|bone_marrow / Manually curated celltypes from each tissue

A2M LRP1 SLC39A14 EPAS1

5.88e-051745440746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCellfacs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP SEMA7A MMRN2 EPAS1

5.88e-0517454440bb87d219aafab0357ab0d797efd38085fc0312
ToppCell5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M GABRG1 MMRN2 EPAS1

5.88e-0517454442735f6a8e5ec36dd3d35aceea6d37cf3eaa1871
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M EPAS1 RYR2 PDZRN4

6.01e-05175544316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M EPAS1 RYR2 PDZRN4

6.01e-05175544a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellfacs-Marrow-T_cells-18m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 NRXN2 TNNI2 CYTH4

6.14e-0517654474f851a398c7562dd713bc0d8d488c0037243112
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|343B / Donor, Lineage, Cell class and subclass (all cells)

A2M MOXD1 NRXN2 LRP1

6.14e-051765442e94bbe17c0bb65dc58b4ebc0cb829258bd7373b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRG3 MOXD1 PIR PDZRN4

6.14e-05176544b4a23d8d1414434adeb237a96f28c825f1aebd77
ToppCellfacs-Marrow-T_cells-18m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 NRXN2 TNNI2 CYTH4

6.14e-0517654431b5459a978d5cdde0af03a77401e0464d8c95ba
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRG3 MOXD1 PIR PDZRN4

6.14e-0517654466c9c6b59030f67e8d746a9c6930e50923f2ded1
ToppCell343B-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|343B / Donor, Lineage, Cell class and subclass (all cells)

A2M MOXD1 NRXN2 LRP1

6.14e-05176544f33ab41d121b59d871ad7d48ca021524a027d2ef
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M MOXD1 NRXN2 RYR2

6.28e-05177544cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

A2M MOXD1 NRXN2 RYR2

6.28e-05177544db222faaecbe5600da39277243c4e7e764eb63c9
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Immature_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M EPAS1 RYR2 EHD2

6.42e-05178544e5e4742e35c3d90f82b830d77bdbdc45828c7deb
ToppCell5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M MMRN2 EPAS1 EHD2

6.42e-05178544360d7a987f91d6d721487a921824057ec31a7332
ToppCellEndothelial-A-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

SELP NRXN2 MMRN2 EPAS1

6.42e-051785442f2602b9305d55f25afa9861dd6c6347ae179337
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SEMA7A GDAP1 MMRN2 EPAS1

6.42e-05178544a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCellCOPD-Endothelial-VE_Venous|World / Disease state, Lineage and Cell class

SELP SLC39A14 EPAS1 PDZRN4

6.56e-051795449968da1adcb561d9bf167a42ab5d9de85c071c4a
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NEU4 SEMA7A TNNI2 CYTH4

6.56e-051795449fc44637c9a7551fd47b8533e45a9c199e164a95
ToppCelldroplet-Spleen-nan-24m-Myeloid-macrophage_dendritic_cell_progenitor|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGAP32 NRXN2 TNNI2 PIR

6.56e-05179544d50d29f26d5a2cd8c4cd4e1244e1bb8de072d159
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M MOXD1 LRP1 EPAS1

6.70e-05180544ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MAGI2 MOXD1 LRP1 RYR2

6.70e-0518054408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SLC39A14 PIR CYTH4

6.70e-05180544bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c02-AQP3|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

A2M ACADVL SPATA31A7 TEP1

6.70e-0518054481d60f0fa9e3b5bfcec85139a0a49e9130145f0e
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN2 SLC39A14 PIR CYTH4

6.70e-0518054482965ed1b72a1873c24dd4553d39681596057316
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP MOXD1 MMRN2 EPAS1

6.85e-0518154472c28baf4fd417ff4a7068603830d55074960144
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP MMRN2 EPAS1 EHD2

6.85e-051815444d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCellfacs-Marrow-B-cells-18m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CEBPE NRXN2 PIR CYTH4

6.85e-05181544e6c78038b14100e0c9c6fe25e8f0b75c02c33549
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial-vein_endothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP MOXD1 MMRN2 EPAS1

6.85e-051815442ac4d3e8987d5a009d7908d8787e18165826202a
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

MACC1 NRXN2 BRME1 KCNH3

6.85e-05181544cc7ae1221a28bc404138a7efee0ad08a19cc3d86
ToppCellfacs-Lung-3m-Endothelial-venous_endothelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP MOXD1 MMRN2 EPAS1

6.85e-051815442628c7ac345eaaeecf8e34617e81948925962cb9
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP MMRN2 EPAS1 EHD2

7.00e-05182544c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP SEMA7A MMRN2 EPAS1

7.00e-05182544840427d1c23d60482c943ff006b14007ed44d247
ToppCelldroplet-Lung-21m-Endothelial-arterial_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SELP MMRN2 EPAS1 EHD2

7.00e-05182544d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SELP MMRN2 EPAS1 EHD2

7.15e-051835443427f3cbe6ea81709750e7dd3ff378f03ae65eab
Drugnerisopam

GABRG1 GABRG3 TH

2.98e-0613513CID000065875
Drugoudenone

TH PAH

4.92e-062512CID000160199
DrugN-methyl-DL-aspartic acid

PRKD3 GABRG1 MAGI2 GABRG3 TH ARHGAP32 PAH LRP1 RYR2

1.32e-05655519CID000004376
DrugDMPH2

TH PAH

1.47e-053512CID006453850
Drug7,8-Dihydrobiopterin

TH PAH

1.47e-053512DB04400
DrugTetrahydrobiopterin

TH PAH

2.94e-054512DB00360
DrugL75-4

TH PAH

2.94e-054512CID000151513
DrugBicuculline

GABRG1 TH RYR2

3.71e-0529513ctd:D001640
Drug4-vinylcatechol

TH PAH

4.90e-055512CID000151398
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

GABRG3 IFT140 PLAG1 BCL6 TEP1

6.77e-051915154451_UP
Drugbiotinyl-L-lysine

GABRG1 GABRG3 TH PAH

7.18e-0599514CID000083814
DrugPiromidic acid [19562-30-2]; Up 200; 13.8uM; MCF7; HT_HG-U133A

A2M GABRG3 TH CYTH4 PDZRN4

7.47e-051955153335_UP
DrugScopolamin-N-oxide hydrobromide [6106-81-6]; Up 200; 10uM; MCF7; HT_HG-U133A

MAGI2 MOXD1 SEMA7A BCL6 EPAS1

7.65e-051965152262_UP
Drugivermectin

GABRG1 GABRG3 MOXD1 TEP1

7.77e-05101514CID006435110
DrugGuaifenesin [93-14-1]; Up 200; 20.2uM; MCF7; HT_HG-U133A

PRKD3 IFT140 ARHGAP32 ULK2 RYR2

7.84e-051975153431_UP
DrugNiridazole [61-57-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

IFT140 TH TEP1 RYR2 EHD2

7.84e-051975153301_DN
DrugVigabatrin [60643-86-9]; Up 200; 31uM; PC3; HT_HG-U133A

IFT140 ARHGAP32 SEMA7A PLAG1 CYTH4

7.84e-051975156314_UP
DrugEthamsylate [2624-44-4]; Down 200; 15.2uM; PC3; HT_HG-U133A

MOXD1 LRP1 TRIOBP BCL6 TEP1

8.03e-051985154576_DN
Drugsevoflurane

PRKD3 SELP GABRG1 GABRG3

9.03e-05105514CID000005206
DiseaseNeurobehavioral Manifestations

SELP MAGI2

1.84e-0412502C0525041
Diseaseacute lymphoblastic leukemia

MAGI2 CEBPE RYR2

1.94e-0466503EFO_0000220
DiseaseAutosome Abnormalities

KMT2A EPAS1

3.33e-0416502C0004403
DiseaseChromosome Aberrations

KMT2A EPAS1

3.33e-0416502C0008625
DiseaseAutism Spectrum Disorders

NRXN2 PAH RYR2

4.10e-0485503C1510586
DiseaseSchizophrenia

MAGI2 ARHGAP32 NRXN2 PAH LRP1 KMT2A PCNT

6.83e-04883507C0036341
Diseasediastolic blood pressure, systolic blood pressure

CCDC62 LRP1 MMRN2 BCL6 CMC2 RYR2

9.11e-04670506EFO_0006335, EFO_0006336
DiseaseUnipolar Depression

SELP TH LRP1 PCNT

9.73e-04259504C0041696
Diseasegranulocyte percentage of myeloid white cells

UBR2 THADA CEBPE BCL6

1.10e-03268504EFO_0007997

Protein segments in the cluster

PeptideGeneStartEntry
CEPIQHPSHMDIPLD

EPAS1

226

Q99814
CHPSNFIIEAPGHMS

CCDC62

516

Q6P9F0
AHCGQTAMHLPPTLA

CEBPE

146

Q15744
HHISPGDFPDCQKMQ

EHD2

346

Q9NZN4
MDLCHPEPAELSSGE

CYTH4

1

Q9UIA0
LEPMSHELPCGHTQT

A2M

461

P01023
PFLLSDSCHSLHPME

PDZRN4

361

Q6ZMN7
DPHSLEMVLIGCHGS

KCNH3

1056

Q9ULD8
PHSLHSMPTDGQLDG

MAGI2

566

Q86UL8
GSPAHPHFMDAELCS

MGME1

301

Q9BQP7
TGPNCEHHDSMAIPE

MMRN2

126

Q9H8L6
PHMTGPRCEEHVFSQ

LRP1

4401

Q07954
LPMDAYTHGCILHPE

GDAP1

131

Q8TB36
HAEMPCSEEPAHGLQ

PIR

101

O00625
CSEEEHPMEGPAHLT

NRXN2

241

Q9P2S2
HHPGIVNLECMFETP

PRKD3

631

O94806
EHRSMNPCPVHDAGT

NEU4

81

Q8WWR8
KLPDMGCSLPEHRAH

ARHGAP32

1866

A7KAX9
DHPPEQCGMFTVSDH

PCNT

111

O95613
MYTPEPDICHELLGH

PAH

276

P00439
DPQSSMLGCLHHPEE

BRME1

31

Q0VDD7
QLHNFPMDEHSCPLE

GABRG1

191

Q8N1C3
HNFPMDEHSCPLIFS

GABRG3

176

Q99928
MHPDLSPHLHTEECN

CMC2

1

Q9NRP2
ASNHCPQDAMIPHGD

COBL

521

O75128
QSPQHAEMCLHTAGP

BCL6

481

P41182
DPPHMLNHDLSCTVS

MACC1

256

Q6ZN28
HLEAPSEGTMDCVHP

SELP

326

P16109
QGHMDADHISSPPCG

KMT2A

2996

Q03164
DLDHMIPQHCSSELD

SLC39A14

281

Q15043
LLHGHMDECLTVPSG

RYR2

236

Q92736
DEVEPGCHHIPQMVS

IFT140

741

Q96RY7
SECLLSMVEEGNPHH

UTP23

101

Q9BRU9
LHCMDPGEWLPQTEH

THADA

1611

Q6YHU6
HLSRHPPETCQMEAG

SPATA31A7

301

Q8IWB4
RSPASCHEHPMADDP

OSBPL10

506

Q9BXB5
SLVPSMDSLHECPHI

TRIOBP

1146

Q9H2D6
VPEMLHNDASDHGCS

SLC39A6

706

Q13433
EGHPTAQHEKMLCDT

ACADVL

591

P49748
TCPIDMDTVHPSHHL

PLAG1

316

Q6DJT9
AEHCPPLHIPGSMSE

TNNI2

46

P48788
HLSRHPPETCQMEAG

SPATA31A3

301

Q5VYP0
QPSELHPMACTHVLH

RNF214

666

Q8ND24
HSGPISHCAAAMEPR

TEP1

2186

Q99973
LESGHECYHPNMPDA

MOXD1

251

Q6UVY6
HLSRHPPETCQMEAG

SPATA31A5

301

Q5VU36
HPVMCSHFTQDLPPE

ZNF679

86

Q8IYX0
PEDGIMAEHLLGHAC

SEMA7A

631

O75326
VPHNISSDHSCDMPV

ULK2

356

Q8IYT8
QHEMVDEPTGICPHF

ZNF91

76

Q05481
DEEDRHHRMPCPAQS

SEMA3E

686

O15041
HTPDGEPCGLMNHLT

POLR1B

501

Q9H9Y6
DPLFMHPDLSCGTHT

UBR2

1151

Q8IWV8
EPDCCHELLGHVPML

TH

356

P07101