Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	positive regulation of cell projection organization	ATP7A KALRN SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 MTOR LRP1 LRRC7 DMD DNM2	9.79e-07	494	102	13	GO:0031346
GeneOntologyBiologicalProcess	positive regulation of neurogenesis	KALRN SMURF1 OBSL1 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR LRP1 MYRF	1.44e-06	354	102	11	GO:0050769
GeneOntologyBiologicalProcess	neuron projection morphogenesis	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 CLU LRP1 PRMT3 RERE DMD DNM2	1.96e-06	802	102	16	GO:0048812
GeneOntologyBiologicalProcess	positive regulation of cell development	TRAF6 KALRN SMURF1 OBSL1 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR LRP1 PDE5A MYRF FOXP3	1.97e-06	614	102	14	GO:0010720
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 CLU LRP1 PRMT3 RERE DMD DNM2	2.57e-06	819	102	16	GO:0120039
GeneOntologyBiologicalProcess	positive regulation of cell differentiation	TRAF6 KALRN SMURF1 OBSL1 FOXA2 CASK LIMK1 NEUROD1 CSH1 CSH2 SNAP91 CLU MTOR LRP1 PDE5A DMD TBX20 MYRF FOXP3	2.81e-06	1141	102	19	GO:0045597
GeneOntologyBiologicalProcess	cell projection morphogenesis	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 CLU LRP1 PRMT3 RERE DMD DNM2	2.86e-06	826	102	16	GO:0048858
GeneOntologyBiologicalProcess	neuron projection development	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 RAP1GAP2 TSC2 CASK LIMK1 NEUROD1 SNAP91 CLU MTOR LRP1 LRRC7 PRMT3 RERE DMD DNM2	4.11e-06	1285	102	20	GO:0031175
GeneOntologyBiologicalProcess	positive regulation of nervous system development	KALRN SMURF1 OBSL1 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR LRP1 MYRF	7.08e-06	418	102	11	GO:0051962
GeneOntologyBiologicalProcess	neuron development	ATP7A TRIO KALRN CEP290 LRRK2 SMURF1 OBSL1 RAP1GAP2 TSC2 CASK LIMK1 NEUROD1 SNAP91 CLU MTOR LRP1 LRRC7 PRMT3 RERE DMD DNM2	7.97e-06	1463	102	21	GO:0048666
GeneOntologyBiologicalProcess	regulation of neurogenesis	KALRN SMURF1 OBSL1 TSC2 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR LRP1 MYRF	9.09e-06	515	102	12	GO:0050767
GeneOntologyBiologicalProcess	regulation of neuron projection development	KALRN LRRK2 SMURF1 OBSL1 RAP1GAP2 TSC2 CASK LIMK1 SNAP91 MTOR LRP1 LRRC7 DMD	1.01e-05	612	102	13	GO:0010975
GeneOntologyBiologicalProcess	regulation of cell size	ATP7A SMURF1 RAP1GAP2 TSC2 LIMK1 MTOR LRP1 DNM2	1.61e-05	225	102	8	GO:0008361
GeneOntologyBiologicalProcess	regulation of plasma membrane bounded cell projection organization	ATP7A KALRN LRRK2 SMURF1 OBSL1 RAP1GAP2 TSC2 CASK LIMK1 SNAP91 MTOR LRP1 LRRC7 DMD DNM2	1.73e-05	846	102	15	GO:0120035
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 LRP1 PRMT3 RERE DNM2	1.87e-05	748	102	14	GO:0048667
GeneOntologyBiologicalProcess	regulation of cell projection organization	ATP7A KALRN LRRK2 SMURF1 OBSL1 RAP1GAP2 TSC2 CASK LIMK1 SNAP91 MTOR LRP1 LRRC7 DMD DNM2	2.18e-05	863	102	15	GO:0031344
GeneOntologyBiologicalProcess	dendritic spine organization	LGMN KALRN LRRK2 CKAP5 CASK PRMT3	2.30e-05	115	102	6	GO:0097061
GeneOntologyBiologicalProcess	regulation of cell development	TRAF6 KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR CLPTM1 LRP1 PDE5A MYRF FOXP3	2.49e-05	1095	102	17	GO:0060284
GeneOntologyBiologicalProcess	neuron projection organization	LGMN KALRN LRRK2 CKAP5 CASK PRMT3	4.02e-05	127	102	6	GO:0106027
GeneOntologyBiologicalProcess	dendrite development	ATP7A KALRN LRRK2 OBSL1 TSC2 CASK MTOR PRMT3 RERE	4.30e-05	335	102	9	GO:0016358
GeneOntologyBiologicalProcess	dendrite morphogenesis	ATP7A KALRN LRRK2 OBSL1 CASK PRMT3 RERE	5.78e-05	198	102	7	GO:0048813
GeneOntologyBiologicalProcess	regulation of nervous system development	KALRN SMURF1 OBSL1 TSC2 CASK LIMK1 CSH1 CSH2 SNAP91 MTOR LRP1 MYRF	6.06e-05	625	102	12	GO:0051960
GeneOntologyBiologicalProcess	dendritic spine development	KALRN LRRK2 TSC2 CASK MTOR PRMT3	7.21e-05	141	102	6	GO:0060996
GeneOntologyBiologicalProcess	regulation of response to nutrient levels	CSH1 CSH2 MTOR NR1H4	7.84e-05	46	102	4	GO:0032107
GeneOntologyBiologicalProcess	locomotory behavior	ATP7A KALRN LRRK2 CKAP5 FOXA2 GRM6 MTOR DMD	8.39e-05	284	102	8	GO:0007626
GeneOntologyBiologicalProcess	myelin maintenance	DEGS1 CLU MYRF	9.08e-05	18	102	3	GO:0043217
GeneOntologyBiologicalProcess	positive regulation of endocytosis	LRRK2 CKAP5 SNAP91 CLU IGHG2 LRP1 DNM2	9.14e-05	213	102	7	GO:0045807
GeneOntologyBiologicalProcess	positive regulation of cellular component organization	ATP7A KALRN LRRK2 CKAP5 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 CLU MTOR IGHG2 LRP1 LRRC7 DMD CNOT1 DNM2	1.18e-04	1366	102	18	GO:0051130
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase III	ZNF143 FOXA2 MTOR	1.26e-04	20	102	3	GO:0045945
GeneOntologyBiologicalProcess	negative regulation of intracellular signal transduction	VEPH1 LRRK2 ARMC10 TSC2 CLU MTOR LRP1 IRAK3 DMD TBX20 CNOT1 NR1H4 PDE11A	1.48e-04	795	102	13	GO:1902532
GeneOntologyBiologicalProcess	postsynapse organization	LGMN KALRN LRRK2 CKAP5 TSC2 LRRC4 CASK PRMT3	1.64e-04	313	102	8	GO:0099173
GeneOntologyBiologicalProcess	positive regulation of developmental growth	SMURF1 LIMK1 CSH1 CSH2 MTOR LRP1 TBX20	1.82e-04	238	102	7	GO:0048639
GeneOntologyBiologicalProcess	response to organic cyclic compound	TET2 LRRK2 TMEM38B PRDM2 PPP5C CSH1 CSH2 MTOR IRAK3 TAF2 MYRF CNOT1 NR1H4 DNM2 FOXP3	1.93e-04	1048	102	15	GO:0014070
GeneOntologyBiologicalProcess	positive regulation of neuron projection development	KALRN TSC2 CASK MTOR LRP1 LRRC7 DMD	2.39e-04	249	102	7	GO:0010976
GeneOntologyBiologicalProcess	central nervous system myelin maintenance	CLU MYRF	2.40e-04	5	102	2	GO:0032286
GeneOntologyBiologicalProcess	regulation of developmental growth	LGMN SMURF1 LIMK1 CSH1 CSH2 MTOR LRP1 TBX20 DNM2	2.42e-04	421	102	9	GO:0048638
GeneOntologyBiologicalProcess	cell morphogenesis	ATP7A TRIO KALRN LRRK2 SMURF1 OBSL1 TSC2 CASK LIMK1 SNAP91 CLU LRP1 PRMT3 RERE DMD DNM2	2.45e-04	1194	102	16	GO:0000902
GeneOntologyBiologicalProcess	protein localization to cell periphery	TRAF6 KALRN SMURF1 TSC2 ARHGEF16 CASK TTC7A LRP1 LRRC7	2.47e-04	422	102	9	GO:1990778
GeneOntologyBiologicalProcess	positive regulation of transport	ATP7A CEP290 LRRK2 CKAP5 GRM6 CASK CSH1 CSH2 SNAP91 CLU IGHG2 LRP1 DMD NR1H4 DNM2	2.70e-04	1081	102	15	GO:0051050
GeneOntologyBiologicalProcess	positive regulation of growth	SMURF1 ARMC10 LIMK1 CSH1 CSH2 MTOR LRP1 TBX20	2.81e-04	339	102	8	GO:0045927
GeneOntologyBiologicalProcess	positive regulation of lipid biosynthetic process	ELOVL5 CSH1 CSH2 MTOR NR1H4	3.38e-04	121	102	5	GO:0046889
GeneOntologyBiologicalProcess	protein targeting to vacuole involved in autophagy	SMURF1 CLU	3.59e-04	6	102	2	GO:0071211
GeneOntologyBiologicalProcess	positive regulation of dendritic spine development	KALRN TSC2 CASK MTOR	4.02e-04	70	102	4	GO:0060999
GeneOntologyBiologicalProcess	synaptic vesicle localization	LRRK2 SNAP91 CTBP1 DNM2	4.25e-04	71	102	4	GO:0097479
GeneOntologyBiologicalProcess	lung alveolus development	ATP7A TMEM38B CSH1 CSH2	5.23e-04	75	102	4	GO:0048286
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen via MHC class II	LGMN TRAF6 DNM2	5.25e-04	32	102	3	GO:0019886
GeneOntologyBiologicalProcess	positive regulation of lamellipodium assembly	ATP7A MTOR DNM2	5.25e-04	32	102	3	GO:0010592
GeneOntologyBiologicalProcess	regulation of transcription by RNA polymerase III	ZNF143 FOXA2 MTOR	5.25e-04	32	102	3	GO:0006359
GeneOntologyBiologicalProcess	localization within membrane	TRAF6 KALRN VPS50 SMURF1 TSC2 LRRC4 ARHGEF16 CASK TTC7A LRP1 LRRC7 DNM2	5.75e-04	798	102	12	GO:0051668
GeneOntologyBiologicalProcess	axon ensheathment in central nervous system	CKAP5 CLU MYRF	5.75e-04	33	102	3	GO:0032291
GeneOntologyBiologicalProcess	central nervous system myelination	CKAP5 CLU MYRF	5.75e-04	33	102	3	GO:0022010
GeneOntologyBiologicalProcess	habituation	KALRN CKAP5	6.65e-04	8	102	2	GO:0046959
GeneOntologyBiologicalProcess	negative regulation of macroautophagy	LRRK2 TSC2 MTOR	6.85e-04	35	102	3	GO:0016242
GeneOntologyBiologicalProcess	regulation of endocytosis	LRRK2 CKAP5 TSC2 SNAP91 CLU IGHG2 LRP1 DNM2	6.98e-04	389	102	8	GO:0030100
GeneOntologyBiologicalProcess	dendritic spine morphogenesis	KALRN LRRK2 CASK PRMT3	7.00e-04	81	102	4	GO:0060997
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class II	LGMN TRAF6 DNM2	7.45e-04	36	102	3	GO:0002495
GeneOntologyBiologicalProcess	central nervous system development	DMXL2 ATP7A CEP290 LRRK2 CKAP5 FOXA2 NEUROD1 CLU MTOR LRP1 RERE DMD TBX20 MYRF FOXP3	7.84e-04	1197	102	15	GO:0007417
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	LGMN TRAF6 DNM2	8.73e-04	38	102	3	GO:0002504
GeneOntologyCellularComponent	somatodendritic compartment	ATP7A KALRN CYP11B2 LRRK2 ELOVL5 CKAP5 SMURF1 TSC2 GRM6 LRRC4 CASK PPP5C SNAP91 CLU MTOR LRP1 LRRC7 DMD PDE11A	9.00e-06	1228	104	19	GO:0036477
GeneOntologyCellularComponent	perinuclear region of cytoplasm	LGMN TRAF6 ATP7A KALRN VPS50 OBSL1 RAP1GAP2 TSC2 CASK CCNT2 LIMK1 CLU LRP1 DMD DNM2	5.84e-05	934	104	15	GO:0048471
GeneOntologyCellularComponent	neuronal cell body	ATP7A KALRN LRRK2 ELOVL5 CKAP5 SMURF1 TSC2 CASK PPP5C SNAP91 MTOR LRP1 DMD PDE11A	6.67e-05	835	104	14	GO:0043025
GeneOntologyCellularComponent	dendrite	ATP7A CYP11B2 LRRK2 ELOVL5 CKAP5 TSC2 GRM6 LRRC4 CASK PPP5C CLU MTOR LRP1 LRRC7	8.91e-05	858	104	14	GO:0030425
GeneOntologyCellularComponent	dendritic tree	ATP7A CYP11B2 LRRK2 ELOVL5 CKAP5 TSC2 GRM6 LRRC4 CASK PPP5C CLU MTOR LRP1 LRRC7	9.13e-05	860	104	14	GO:0097447
GeneOntologyCellularComponent	cell body	ATP7A KALRN LRRK2 ELOVL5 CKAP5 SMURF1 TSC2 CASK PPP5C SNAP91 MTOR LRP1 DMD PDE11A	2.04e-04	929	104	14	GO:0044297
GeneOntologyCellularComponent	site of polarized growth	LRRK2 TSC2 GRM6 LIMK1 CLU LRP1 DNM2	2.74e-04	253	104	7	GO:0030427
GeneOntologyCellularComponent	growth hormone receptor complex	CSH1 CSH2	3.63e-04	6	104	2	GO:0070195
GeneOntologyCellularComponent	postsynaptic density	ATP7A KALRN TSC2 LRRC4 SNAP91 LRP1 LRRC7 DMD DNM2	4.21e-04	451	104	9	GO:0014069
GeneOntologyCellularComponent	extrinsic component of presynaptic endocytic zone membrane	SNAP91 CTBP1	5.07e-04	7	104	2	GO:0098894
GeneOntologyCellularComponent	postsynapse	ATP7A TRIO KALRN LRRK2 TSC2 GRM6 LRRC4 LIMK1 SNAP91 MTOR LRP1 LRRC7 DMD DNM2	5.14e-04	1018	104	14	GO:0098794
GeneOntologyCellularComponent	asymmetric synapse	ATP7A KALRN TSC2 LRRC4 SNAP91 LRP1 LRRC7 DMD DNM2	6.29e-04	477	104	9	GO:0032279
GeneOntologyCellularComponent	glutamatergic synapse	TRAF6 TRIO KALRN LRRK2 TSC2 LRRC4 LIMK1 MTOR LRP1 CTBP1 LRRC7 DNM2	7.50e-04	817	104	12	GO:0098978
GeneOntologyCellularComponent	postsynaptic specialization	ATP7A KALRN TSC2 LRRC4 SNAP91 LRP1 LRRC7 DMD DNM2	9.15e-04	503	104	9	GO:0099572
GeneOntologyCellularComponent	neuron to neuron synapse	ATP7A KALRN TSC2 LRRC4 SNAP91 LRP1 LRRC7 DMD DNM2	1.20e-03	523	104	9	GO:0098984
GeneOntologyCellularComponent	growth cone	LRRK2 TSC2 LIMK1 CLU LRP1 DNM2	1.42e-03	245	104	6	GO:0030426
GeneOntologyCellularComponent	presynaptic endocytic zone membrane	SNAP91 CTBP1	2.15e-03	14	104	2	GO:0098835
MousePheno	abnormal neuroendocrine gland morphology	DMXL2 TRAF6 CYP11B2 PRDM2 NEUROD1 CSH1 CSH2 DMD	5.57e-06	156	87	8	MP:0000631
MousePheno	abnormal pituitary gland morphology	DMXL2 TRAF6 CYP11B2 PRDM2 CSH1 CSH2 DMD	2.06e-05	135	87	7	MP:0000633
MousePheno	abnormal forebrain morphology	DMXL2 TRAF6 ATP7A TRIO KALRN CYP11B2 CEP290 LRRK2 PRDM2 LIMK1 NEUROD1 CSH1 CSH2 MTOR LRP1 RERE DMD TBX20 PDE11A	2.55e-05	1072	87	19	MP:0000783
Domain	ARM-type_fold	USP34 INTS7 VEPH1 LRRK2 USP24 CKAP5 ARMC10 TSC2 PPP6R1 MTOR TAF2	2.45e-06	339	102	11	IPR016024
Domain	PH	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 ARAP2 DNM2	3.68e-05	229	102	8	PF00169
Domain	ZINC_FINGER_C2H2_2	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 KIN ZNF398 PRMT3 ZNF160 ZFP2 ZNF292 FOXP3	8.02e-05	775	102	14	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 KIN ZNF398 PRMT3 ZNF160 ZFP2 ZNF292 FOXP3	8.24e-05	777	102	14	PS00028
Domain	Znf_C2H2-like	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 KIN ZNF398 PRMT3 ZNF160 ZFP2 ZNF292 FOXP3	1.06e-04	796	102	14	IPR015880
Domain	ZnF_C2H2	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 KIN ZNF398 PRMT3 ZNF160 ZFP2 ZNF292 FOXP3	1.25e-04	808	102	14	SM00355
Domain	PH	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 ARAP2 DNM2	1.43e-04	278	102	8	SM00233
Domain	PH_DOMAIN	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 ARAP2 DNM2	1.46e-04	279	102	8	PS50003
Domain	PH_domain	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 ARAP2 DNM2	1.50e-04	280	102	8	IPR001849
Domain	Kinase-like_dom	CDC42BPA TRIO KALRN LRRK2 PRDM2 CASK LIMK1 MTOR IRAK3 DMD DNM2	1.82e-04	542	102	11	IPR011009
Domain	Spectrin	TRIO KALRN DMD	2.59e-04	23	102	3	PF00435
Domain	-	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 RABGAP1L ARAP2 DNM2	2.90e-04	391	102	9	2.30.29.30
Domain	-	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 ZNF398 ZNF160 ZFP2 ZNF292 FOXP3	3.28e-04	679	102	12	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 ZNF398 ZNF160 ZFP2 ZNF292 FOXP3	4.00e-04	694	102	12	IPR013087
Domain	Znf_C2H2	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 ZNF398 PRMT3 ZNF160 ZFP2 ZNF292 FOXP3	4.35e-04	805	102	13	IPR007087
Domain	SOMATOTROPIN_2	CSH1 CSH2	4.37e-04	6	102	2	PS00338
Domain	SOMATOTROPIN_1	CSH1 CSH2	4.37e-04	6	102	2	PS00266
Domain	Hormone_1	CSH1 CSH2	4.37e-04	6	102	2	PF00103
Domain	Spectrin_repeat	TRIO KALRN DMD	5.21e-04	29	102	3	IPR002017
Domain	PH_dom-like	CDC42BPA TRIO KALRN VEPH1 ARHGEF16 PLCH2 RABGAP1L ARAP2 DNM2	5.41e-04	426	102	9	IPR011993
Domain	Somatotropin	CSH1 CSH2	6.09e-04	7	102	2	IPR001400
Domain	GAF	PDE5A PDE11A	6.09e-04	7	102	2	PF01590
Domain	SPEC	TRIO KALRN DMD	6.99e-04	32	102	3	SM00150
Domain	Spectrin/alpha-actinin	TRIO KALRN DMD	6.99e-04	32	102	3	IPR018159
Domain	GAF	PDE5A PDE11A	8.09e-04	8	102	2	IPR003018
Domain	GAF	PDE5A PDE11A	8.09e-04	8	102	2	SM00065
Domain	-	PDE5A PDE11A	1.04e-03	9	102	2	3.30.450.40
Domain	GAF_dom-like	PDE5A PDE11A	1.04e-03	9	102	2	IPR029016
Domain	Rap_GAP	RAP1GAP2 TSC2	1.29e-03	10	102	2	PF02145
Domain	-	INTS7 LRRK2 CKAP5 ARMC10 TSC2 MTOR	1.37e-03	222	102	6	1.25.10.10
Domain	zf-C2H2	ZNF438 ZNF143 ZNF559 ZNF485 PRDM2 ZNF599 ZBTB45 ZNF398 ZNF160 ZFP2 ZNF292	1.41e-03	693	102	11	PF00096
Domain	Rap_GAP_dom	RAP1GAP2 TSC2	1.57e-03	11	102	2	IPR000331
Domain	BAH	TNRC18 RERE	1.57e-03	11	102	2	PS51038
Domain	BAH_dom	TNRC18 RERE	1.57e-03	11	102	2	IPR001025
Domain	BAH	TNRC18 RERE	1.57e-03	11	102	2	SM00439
Domain	RAPGAP	RAP1GAP2 TSC2	1.57e-03	11	102	2	PS50085
Domain	BAH	TNRC18 RERE	1.57e-03	11	102	2	PF01426
Domain	Ser/Thr_kinase_AS	CDC42BPA TRIO KALRN LRRK2 CASK LIMK1 IRAK3	3.44e-03	357	102	7	IPR008271
Domain	ARM-like	INTS7 LRRK2 CKAP5 ARMC10 TSC2 MTOR	3.65e-03	270	102	6	IPR011989
Domain	PROTEIN_KINASE_ST	CDC42BPA TRIO KALRN LRRK2 CASK LIMK1 IRAK3	3.71e-03	362	102	7	PS00108
Domain	PDEase	PDE5A PDE11A	4.75e-03	19	102	2	IPR023088
Domain	Pkinase	CDC42BPA TRIO KALRN LRRK2 CASK LIMK1 IRAK3	4.90e-03	381	102	7	PF00069
Domain	DH_1	TRIO KALRN ARHGEF16	4.95e-03	63	102	3	PS00741
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 USP34 DMXL2 TRAF6 TRIO KALRN CEP290 CKAP5 OBSL1 RAP1GAP2 TSC2 LRRC4 CASK LIMK1 UBA7 PPP5C CLU LRP1 CTBP1 DNM2 ZNF292	2.34e-10	1285	105	21	35914814
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TET2 USP34 USP24 CKAP5 PPP6R1 PRDM2 GREB1L LRP1 CTBP1 RERE CNOT1 GOLGB1	5.54e-09	418	105	12	34709266
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DMXL2 TRIO KALRN CKAP5 TSC2 PPP6R1 CASK SNAP91 CLU MTOR LRP1 CTBP1 LRRC7 CNOT1 GOLGB1 DNM2	3.30e-08	963	105	16	28671696
Pubmed	Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors.	FOXA2 CSH1 CSH2 CLU	1.04e-07	15	105	4	12163409
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CKAP5 SMURF1 OBSL1 RAP1GAP2 PPP6R1 STARD9 RABGAP1L LRRC7 RERE ARAP2	4.63e-07	407	105	10	12693553
Pubmed	Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.	CSH1 CSH2 ZNF292	5.31e-07	6	105	3	12166626
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	USP34 ZNF143 RBM33 CKAP5 ZNF485 FOXA2 TMEM38B DEGS1 CCNT2 CLPTM1 LRP1 TAF2 RERE ZNF160 CNOT1 GOLGB1	6.61e-07	1203	105	16	29180619
Pubmed	The rapid activation of protein synthesis by growth hormone requires signaling through mTOR.	CSH1 CSH2 MTOR	9.28e-07	7	105	3	17284572
Pubmed	microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.	CSH1 CSH2 MTOR	9.28e-07	7	105	3	36976763
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 CDC42BPA TRIO CKAP5 TSC2 ARHGEF16 LIMK1 MTOR STARD9 RABGAP1L NHS GOLGB1 ARAP2	2.06e-06	861	105	13	36931259
Pubmed	A census of human transcription factors: function, expression and evolution.	ZNF143 HSFY1 FOXA2 PRDM2 NEUROD1 ZNF398 RERE TBX20 ZNF160 MYRF NR1H4 MBNL3 FOXP3	3.67e-06	908	105	13	19274049
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	AMPD1 ZNF143 ABCA4 USP24 ELOVL5 FBRSL1 MRPS2 IRAK3 TAF2 CNOT1 DNM2	3.81e-06	638	105	11	31182584
Pubmed	Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases.	TTC7A IGHG2 FOXP3	4.33e-06	11	105	3	16492738
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	TRIO KALRN PPP5C SNAP91 CLU DMD	6.85e-06	151	105	6	17043677
Pubmed	TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination.	TRAF6 FOXP3	9.03e-06	2	105	2	30886050
Pubmed	Loss of TSC2 confers resistance to ceramide and nutrient deprivation.	TSC2 MTOR	9.03e-06	2	105	2	23604129
Pubmed	Identification of the interchain disulfide bonds of dimeric human placental lactogen.	CSH1 CSH2	9.03e-06	2	105	2	438159
Pubmed	mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells.	MTOR FOXP3	9.03e-06	2	105	2	26238486
Pubmed	Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis.	SNAP91 DNM2	9.03e-06	2	105	2	23678185
Pubmed	mTORC2 is required for proliferation and survival of TSC2-null cells.	TSC2 MTOR	9.03e-06	2	105	2	21482669
Pubmed	CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6.	LGMN TRAF6	9.03e-06	2	105	2	38047378
Pubmed	Amino acid sequence of human chorionic somatomammotropin.	CSH1 CSH2	9.03e-06	2	105	2	4712450
Pubmed	TRAF6 regulates proliferation and differentiation of skeletal myoblasts.	TRAF6 DMD	9.03e-06	2	105	2	21131124
Pubmed	Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress.	TSC2 MTOR	9.03e-06	2	105	2	23699409
Pubmed	A CCR4-NOT Transcription Complex, Subunit 1, CNOT1, Variant Associated with Holoprosencephaly.	FOXA2 CNOT1	9.03e-06	2	105	2	31006510
Pubmed	TSC2 regulates VEGF through mTOR-dependent and -independent pathways.	TSC2 MTOR	9.03e-06	2	105	2	12957289
Pubmed	Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis.	TSC2 MTOR	9.03e-06	2	105	2	24591652
Pubmed	Two structurally different genes produce the same secreted human placental lactogen hormone.	CSH1 CSH2	9.03e-06	2	105	2	6300056
Pubmed	Oligomeric form of C-terminal-binding protein coactivates NeuroD1-mediated transcription.	NEUROD1 CTBP1	9.03e-06	2	105	2	27880001
Pubmed	Cotranslational sequestration of egg white proteins and placental lactogen inside membrane vesicles.	CSH1 CSH2	9.03e-06	2	105	2	6930851
Pubmed	Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy.	PDE5A DMD	9.03e-06	2	105	2	22653783
Pubmed	Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis.	TET2 FOXP3	9.03e-06	2	105	2	31778687
Pubmed	Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP.	TRIO KALRN	9.03e-06	2	105	2	26858404
Pubmed	mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity.	TSC2 MTOR	9.03e-06	2	105	2	34667149
Pubmed	The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.	FOXA2 NR1H4	9.03e-06	2	105	2	29981427
Pubmed	Development of hypomelanotic macules is associated with constitutive activated mTORC1 in tuberous sclerosis complex.	TSC2 MTOR	9.03e-06	2	105	2	28336152
Pubmed	Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.	NR1H4 FOXP3	9.03e-06	2	105	2	32461639
Pubmed	Analysis of a major human chorionic somatomammotropin gene. Evidence for two functional promoter elements.	CSH1 CSH2	9.03e-06	2	105	2	6208192
Pubmed	Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin.	TSC2 MTOR	9.03e-06	2	105	2	29364507
Pubmed	Sorting out co-occurrence of rare monogenic retinopathies: Stargardt disease co-existing with congenital stationary night blindness.	ABCA4 GRM6	9.03e-06	2	105	2	24397708
Pubmed	Multiple origins of transcription for the human placental lactogen genes.	CSH1 CSH2	9.03e-06	2	105	2	6209277
Pubmed	Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway.	TSC2 MTOR	9.03e-06	2	105	2	22287548
Pubmed	Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy.	TRAF6 DMD	9.03e-06	2	105	2	24163132
Pubmed	Tuberous Sclerosis Complex Protein 2-Independent Activation of mTORC1 by Human Cytomegalovirus pUL38.	TSC2 MTOR	9.03e-06	2	105	2	25972538
Pubmed	T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle.	DMD FOXP3	9.03e-06	2	105	2	31822623
Pubmed	A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2).	TSC2 MTOR	9.03e-06	2	105	2	22492229
Pubmed	Muscle protein synthesis, mTORC1/MAPK/Hippo signaling, and capillary density are altered by blocking of myostatin and activins.	MTOR DMD	9.03e-06	2	105	2	23115080
Pubmed	Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.	TSC2 MTOR	9.03e-06	2	105	2	21886784
Pubmed	mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy.	TSC2 MTOR	9.03e-06	2	105	2	27023784
Pubmed	STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer.	TET2 FOXP3	9.03e-06	2	105	2	30013992
Pubmed	FXR controls insulin content by regulating Foxa2-mediated insulin transcription.	FOXA2 NR1H4	9.03e-06	2	105	2	38135007
Pubmed	Amino-acid sequence of human placental lactogen.	CSH1 CSH2	9.03e-06	2	105	2	5286363
Pubmed	Construction and analysis of recombinant DNA for human chorionic somatomammotropin.	CSH1 CSH2	9.03e-06	2	105	2	593368
Pubmed	Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.	TSC2 MTOR	9.03e-06	2	105	2	24740570
Pubmed	Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation.	NEUROD1 CSH1 CSH2	9.50e-06	14	105	3	14726486
Pubmed	An investigation into the human serum "interactome".	OBSL1 CLU IGHG2 DMD CNOT1 ZNF292	1.02e-05	162	105	6	15174051
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	DMXL2 TRIO KALRN PPP6R1 CLU LRP1 LRRC7	1.17e-05	251	105	7	27507650
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TET2 FBRSL1 SMURF1 RNF213 ZNF160	1.43e-05	101	105	5	10997877
Pubmed	Tpit determines alternate fates during pituitary cell differentiation.	NEUROD1 CSH1 CSH2	2.50e-05	19	105	3	12651892
Pubmed	Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.	CDC42BPA PLCH2 RABGAP1L RERE	2.55e-05	56	105	4	9455484
Pubmed	Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner.	TSC2 MTOR	2.70e-05	3	105	2	17562867
Pubmed	Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.	MTOR FOXP3	2.70e-05	3	105	2	27261457
Pubmed	Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.	ADAMTS4 LRP1	2.70e-05	3	105	2	24474687
Pubmed	Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.	TSC2 MTOR	2.70e-05	3	105	2	15624760
Pubmed	Searching the second hit in patients with inherited retinal dystrophies and monoallelic variants in ABCA4, USH2A and CEP290 by whole-gene targeted sequencing.	ABCA4 CEP290	2.70e-05	3	105	2	30190494
Pubmed	Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway.	MTOR FOXP3	2.70e-05	3	105	2	37121553
Pubmed	Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action.	TRIO KALRN	2.70e-05	3	105	2	31801062
Pubmed	Differential placental expression profile of human Growth Hormone/Chorionic Somatomammotropin genes in pregnancies with pre-eclampsia and gestational diabetes mellitus.	CSH1 CSH2	2.70e-05	3	105	2	22387044
Pubmed	Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain.	TSC2 MTOR	2.70e-05	3	105	2	17018601
Pubmed	mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability.	TSC2 MTOR	2.70e-05	3	105	2	29056426
Pubmed	Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma.	VEPH1 TSC2	2.70e-05	3	105	2	32610114
Pubmed	IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.	IRAK3 FOXP3	2.70e-05	3	105	2	23776703
Pubmed	Mycobacterium tuberculosis lipoarabinomannan-mediated IRAK-M induction negatively regulates Toll-like receptor-dependent interleukin-12 p40 production in macrophages.	TRAF6 IRAK3	2.70e-05	3	105	2	16263713
Pubmed	Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma.	TSC2 MTOR	2.70e-05	3	105	2	26831717
Pubmed	Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα.	FOXA2 NR1H4	2.70e-05	3	105	2	34246806
Pubmed	Eosinophilic Renal Cell Tumors With a TSC and MTOR Gene Mutations Are Morphologically and Immunohistochemically Heterogenous: Clinicopathologic and Molecular Study.	TSC2 MTOR	2.70e-05	3	105	2	32091432
Pubmed	Low-grade oncocytic tumor of kidney harboring TSC/MTOR mutation: clinicopathologic, immunohistochemical and molecular characteristics support a distinct entity.	TSC2 MTOR	2.70e-05	3	105	2	35099634
Pubmed	Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.	MTOR FOXP3	2.70e-05	3	105	2	20972332
Pubmed	Role of the endocytic pathway in the counteraction of BST-2 by human lentiviral pathogens.	SNAP91 DNM2	2.70e-05	3	105	2	21813615
Pubmed	Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway.	TSC2 MTOR	2.70e-05	3	105	2	26735435
Pubmed	Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1.	TSC2 MTOR	2.70e-05	3	105	2	23878397
Pubmed	Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.	TSC2 MTOR	2.70e-05	3	105	2	23592839
Pubmed	SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling.	MTOR NR1H4	2.70e-05	3	105	2	24338587
Pubmed	GLI2 promotes cell proliferation and migration through transcriptional activation of ARHGEF16 in human glioma cells.	CKAP5 ARHGEF16	2.70e-05	3	105	2	30305138
Pubmed	XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons.	TSC2 MTOR	2.70e-05	3	105	2	23348097
Pubmed	Control of Foxp3 stability through modulation of TET activity.	TET2 FOXP3	2.70e-05	3	105	2	26903244
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	TSC2 MTOR	2.70e-05	3	105	2	23966835
Pubmed	CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens.	MTOR FOXP3	2.70e-05	3	105	2	25786177
Pubmed	Effects of MiR-194-5p on the proliferation and invasion of laryngeal cancer cells by regulating the expression of smurf1 and activating the mTOR signaling pathway.	SMURF1 MTOR	2.70e-05	3	105	2	36227673
Pubmed	Placental mTOR complex 1 regulates fetal programming of obesity and insulin resistance in mice.	TSC2 MTOR	2.70e-05	3	105	2	34032632
Pubmed	Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.	TRAF6 IRAK3	2.70e-05	3	105	2	21098228
Pubmed	Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.	TSC2 MTOR	2.70e-05	3	105	2	20615870
Pubmed	Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein: implications for iron metabolism.	TSC2 MTOR	2.70e-05	3	105	2	23508953
Pubmed	The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex.	CSH1 CSH2	2.70e-05	3	105	2	9312053
Pubmed	FXR blocks the growth of liver cancer cells through inhibiting mTOR-s6K pathway.	MTOR NR1H4	2.70e-05	3	105	2	27109477
Pubmed	Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.	TSC2 MTOR	2.70e-05	3	105	2	28289099
Pubmed	The human growth hormone gene locus: structure, evolution, and allelic variations.	CSH1 CSH2	2.70e-05	3	105	2	3030680
Pubmed	Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells.	TET2 FOXP3	2.70e-05	3	105	2	24984151
Pubmed	TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.	TSC2 MTOR	2.70e-05	3	105	2	36715448
Pubmed	Role of TSC-mTOR pathway in diabetic nephropathy.	TSC2 MTOR	2.70e-05	3	105	2	18926585
Interaction	KDM1A interactions	TET2 USP34 VPS50 USP24 CKAP5 OBSL1 PPP6R1 PRDM2 GREB1L CLU RABGAP1L LRP1 CTBP1 RERE CNOT1 GOLGB1 FOXP3	5.38e-06	941	103	17	int:KDM1A
Cytoband	1q42.11	CDC42BPA DEGS1	2.30e-04	10	105	2	1q42.11
Cytoband	1p36.3	MMP23B ARHGEF16	4.63e-04	14	105	2	1p36.3
GeneFamily	Growth hormone family	CSH1 CSH2	2.52e-04	6	75	2	1175
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF438 ZNF143 ZNF559 ZNF485 ZNF599 ZBTB45 ZNF398 ZNF160 ZFP2 ZNF292	7.37e-04	718	75	10	28
CoexpressionAtlas	dev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_500	ATP7A OBSL1 RNF213 GREB1L MBNL3	1.06e-05	61	101	5	gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k3_500
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 USP34 RBM33 RNF213 PRDM2 GOLGB1 ARAP2 ZNF292	2.55e-08	200	105	8	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 USP24 RNF213 HELB GOLGB1 ARAP2 ZNF292	4.70e-07	199	105	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF438 VEPH1 CLU PDE5A DMD LINC02915	4.10e-06	178	105	6	f5d83ad082e31d5601890d245b9fb4f9ef6a062b
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF438 VEPH1 CLU PDE5A DMD LINC02915	4.10e-06	178	105	6	a2a8fc14f492a4695e6991a357b6626145f1bf7f
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF438 VEPH1 CLU PDE5A DMD LINC02915	4.23e-06	179	105	6	510927794bbd21814eba75286e0801eb1fd2e8a6
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF438 VEPH1 CLU PDE5A DMD LINC02915	4.23e-06	179	105	6	906a5ebbbac660b6fd498ced09d0ada40a3e64af
ToppCell	remission-Platelet\|remission / disease stage, cell group and cell class	ZNF438 VEPH1 CLU PDE5A DMD LINC02915	4.66e-06	182	105	6	65e2798aacd670cbc3a8c8e9d1a2f7768513bb70
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF438 KALRN VEPH1 PDE5A DMD LINC02915	5.12e-06	185	105	6	709236097cbfc254796fcc69b5f5178b73dad9bd
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_4\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF438 KALRN VEPH1 PDE5A DMD LINC02915	5.12e-06	185	105	6	af078a6c4a3e0b54b7d8ab7b30dcd06053ebfd28
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 USP24 RNF213 PRDM2 GOLGB1 ARAP2	5.61e-06	188	105	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D175\|Adult / Lineage, Cell type, age group and donor	ZNF438 DMXL2 ARHGAP30 TMEM38B LRP1 IRAK3	6.33e-06	192	105	6	733491e932350e3c216a626cc49c3cd3fe970a82
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	VEPH1 SMURF1 CASK RABGAP1L RERE DMD	7.12e-06	196	105	6	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	VEPH1 LRRK2 RAP1GAP2 CCDC148 NHS NR1H4	7.12e-06	196	105	6	6ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 USP24 RNF213 HELB ARAP2 ZNF292	7.33e-06	197	105	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 TTC7A LRP1 IRAK3	7.55e-06	198	105	6	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	TRIO SMURF1 CASK RABGAP1L RERE DMD	7.55e-06	198	105	6	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 CLU LRP1 IRAK3	7.55e-06	198	105	6	d5e525d2f2226d06a3fb985ce3a33555ff4b2e7b
ToppCell	LPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_only / Treatment groups by lineage, cell group, cell type	CEP290 VEPH1 FOXA2 MYRF GOLGB1 DNM2	7.99e-06	200	105	6	2dadf317a42a7e27cc1fac74f91b806c93a57108
ToppCell	mild-Classical_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 CLU LRP1 IRAK3	7.99e-06	200	105	6	c8b80d4e7f70c66cbbdd0665821bcd5db69c7d35
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42BPA DEGS1 CLPTM1 MYRF ARAP2 DNM2	7.99e-06	200	105	6	f0c338877e39226a90c4effe12f6501d33542a73
ToppCell	control-Neutrophil\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 TNRC18 LRP1 IRAK3	7.99e-06	200	105	6	b5d197472799cc61d7497faed91ac2564ae4930a
ToppCell	control-HLA-DR-_S100A+_Monocyte\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 TNRC18 LRP1 IRAK3	7.99e-06	200	105	6	9e3e13a68bc1110fa000ec2d80f4c654ddbce17e
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	LGMN AMT USP24 STARD9 MBNL3	5.46e-05	172	105	5	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	LGMN AMT USP24 STARD9 MBNL3	5.93e-05	175	105	5	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP7A LRRK2 RAP1GAP2 LRP1 IRAK3	5.93e-05	175	105	5	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	BAL-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ATP7A LRRK2 STARD9 ZNF398 CTBP1	6.60e-05	179	105	5	68511e87b12b8253de7771e5ccfc5869248b8450
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	ZNF438 VEPH1 CLU PDE5A LINC02915	6.60e-05	179	105	5	3b1616e974ea7792ff5c37da3b0281f28edfbb56
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF438 VEPH1 CLU PDE5A LINC02915	6.60e-05	179	105	5	35271a4396a533f6d960ce55d171a32d9d2fd1a4
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega-Platelet\|COVID-19_Convalescent / Disease group, lineage and cell class	ZNF438 VEPH1 CLU PDE5A LINC02915	6.77e-05	180	105	5	deed53167504c91220b35a63366ed7d8f02a5254
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZNF438 VEPH1 CLU PDE5A LINC02915	6.77e-05	180	105	5	3c605d6adb4199963532f3639f2c768f7e575152
ToppCell	COVID-19_Convalescent-Hematopoietic_Mega\|COVID-19_Convalescent / Disease group, lineage and cell class	ZNF438 VEPH1 CLU PDE5A LINC02915	6.77e-05	180	105	5	17323d382ae322e388e230fdad13e3464ea73e8e
ToppCell	megakaryocytic-Platelet\|World / Lineage and Cell class	ZNF438 VEPH1 CLU PDE5A LINC02915	6.77e-05	180	105	5	c007c3e63c2bb35ed34327dd8863899b5db93115
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet-plt_1\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZNF438 VEPH1 CLU PDE5A LINC02915	6.77e-05	180	105	5	3d52ca0568f9c0d6359b302ff5ff41b075f78597
ToppCell	10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|bone_marrow / Manually curated celltypes from each tissue	KALRN VEPH1 CLU PDE5A LINC02915	7.32e-05	183	105	5	3cc9f3dc3bc4bde1d3408b0a6ba58e135a11036d
ToppCell	severe-multiplets\|severe / disease stage, cell group and cell class	AMT INTS7 GRM6 CLU PRMT3	7.32e-05	183	105	5	78af8df48f0fe49ac37ccec0ad7b2993883b1148
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	KALRN VEPH1 CLU PDE5A LINC02915	7.32e-05	183	105	5	9c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCell	(5)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ADAMTS4 PDE5A DMD TBX20 ARAP2	7.91e-05	186	105	5	acbca8cc048d87faf859b3e77bdb38d0a3dad71c
ToppCell	(5)_Pericytes-(50)_Pericytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	ADAMTS4 PDE5A DMD TBX20 ARAP2	7.91e-05	186	105	5	67b59defdd1ed3608229cc5e2a3b480d92312afa
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	RAP1GAP2 GREB1L RABGAP1L LRRC7 DMD	8.32e-05	188	105	5	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	remission-Platelet\|World / disease stage, cell group and cell class	ZNF438 VEPH1 CLU PDE5A LINC02915	8.32e-05	188	105	5	fa69f20ef6b8ce620ba342f0984d40ddf259bc3f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO MC5R LRRC4 CASK LRP1	8.32e-05	188	105	5	a244fcd092d5bd544e503366b1439b0fbc1ee00e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRIO MC5R LRRC4 CASK LRP1	8.32e-05	188	105	5	c8530c9ff98666c64a94683261af4288cb790a7e
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LGMN LRRK2 USP24 IGHG2 RERE	8.74e-05	190	105	5	ed100e271aac82806f59e0c613ccda63f59100c1
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-smooth_muscle_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS4 TMEM38B PDE5A DMD ARAP2	8.74e-05	190	105	5	1ab3f19f1ce9f58e5125135704d94655a2e330a0
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	RAP1GAP2 GREB1L RABGAP1L LRRC7 DMD	8.96e-05	191	105	5	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	Adult-Immune-alveolar_macrophage_(MARCO_positive)-D122\|Adult / Lineage, Cell type, age group and donor	ZNF438 DMXL2 TMEM38B LRP1 IRAK3	9.41e-05	193	105	5	cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	VEPH1 RAP1GAP2 GREB1L DMD ARAP2	9.41e-05	193	105	5	b38aaffbea36ef6c08ebe82675438f873c89b242
ToppCell	HSPCs-Mk_prog.\|HSPCs / Lineage and Cell class	ABCA4 KALRN CLU RABGAP1L PDE5A	9.64e-05	194	105	5	5c05d508f5c29e6efe87506bf59e3b0fe5922f65
ToppCell	Children_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZNF438 DMXL2 TMEM38B LRP1 IRAK3	9.87e-05	195	105	5	9d649ac7d2af313481069c95349efc0c68449e2b
ToppCell	Smart-seq2-bone_marrow_(Smart-seq2)-myeloid\|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DMXL2 LRRK2 TNRC18 LRP1 IRAK3	9.87e-05	195	105	5	b0dbaae86f5703ab62f925e0f36500274044884a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VEPH1 RAP1GAP2 CCDC148 NHS RERE	9.87e-05	195	105	5	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	TET2 DMXL2 LRRK2 RAP1GAP2 IRAK3	9.87e-05	195	105	5	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	TET2 DMXL2 LRRK2 RAP1GAP2 IRAK3	1.01e-04	196	105	5	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	(7)_Monocyte\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.01e-04	196	105	5	0232167559dcd2d86ee8b78017cf5f2a084b2cb7
ToppCell	(7)_MNP-(7)_Monocyte\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.01e-04	196	105	5	4c2ea16352ba3482c02c03866460e0d975f9fc99
ToppCell	Int-URO-Myeloid-CD14_Mono\|Int-URO / Disease, Lineage and Cell Type	DMXL2 LRRK2 CLU LRP1 IRAK3	1.01e-04	196	105	5	e6a897c29404119fb40c29033d0198a866015bf8
ToppCell	COVID-granulo1-\|COVID / Condition, Cell_class and T cell subcluster	TET2 DMXL2 LRRK2 LRP1 IRAK3	1.04e-04	197	105	5	190392117dc6269a21983bd3e554066fd48acd5e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRK2 CCDC148 CLU NHS NR1H4	1.04e-04	197	105	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RNF213 HELB STARD9 ARAP2 ZNF292	1.04e-04	197	105	5	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	LRRK2 OBSL1 FOXA2 RABGAP1L GOLGB1	1.04e-04	197	105	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	DMXL2 RAP1GAP2 RNF213 ARHGAP30 IRAK3	1.04e-04	197	105	5	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	COVID-granulo1\|COVID / Condition, Cell_class and T cell subcluster	TET2 DMXL2 LRRK2 LRP1 IRAK3	1.04e-04	197	105	5	4cd774d9d5a6bf7729dc6b7bcd3ddfe3f3051ada
ToppCell	wk_15-18-Epithelial-Distal_epithelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	VEPH1 FOXA2 CLU DMD MYRF	1.04e-04	197	105	5	b7aff83c27606d87565382a768119a863fe1c294
ToppCell	Influenza_Severe-Classical_Monocyte\|World / Disease group and Cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.04e-04	197	105	5	e9a01f0fbbeaf6b23bce4603f62053c003848da4
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CEP290 VEPH1 FOXA2 GOLGB1 DNM2	1.04e-04	197	105	5	3d13a4f2e86422900ee2194e8a1fd1cf9750d5d3
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	TET2 DMXL2 LRRK2 LRP1 IRAK3	1.04e-04	197	105	5	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	COVID-19_Moderate-Classical_Monocyte\|World / disease group, cell group and cell class	TET2 DMXL2 LRRK2 LRP1 IRAK3	1.04e-04	197	105	5	16cf3939e700aef1e16159f0652ba2dfad287e7a
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 RAP1GAP2 RNF213 ARHGAP30 IRAK3	1.06e-04	198	105	5	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	cf0fda1a24449cfd8ed56ffc7841d8accb187949
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	7e1f08dae11a7cc7949a5622d82c7e6660d06dea
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	525adc91fd8f2ad957b1879a5bf3950baa7d5ef8
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	70e62d815b2a0aa5327ff94d6f4d503176e007b9
ToppCell	COVID-19_Severe-Myeloid-Classical_Monocyte\|COVID-19_Severe / Disease group, lineage and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	dfe92577c7d1e63315c7564d5d99362c6e7d4d46
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	0128d00e6c3f99a026329dd169c0ea5e0e24c59c
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	51c220507bb05aa6338fec494b8ecf4902437708
ToppCell	COVID-19_Mild-Classical_Monocyte\|COVID-19_Mild / Disease condition and Cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.06e-04	198	105	5	30ada3de865b6fb2b14196a1cbfd4740c6a57ce3
ToppCell	mild-HLA-DR-_S100A+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	d0d286eafe935f9b3aaba5b783e8911251121b4a
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	9314eb9a89407738626a0384884454b5f9031ee7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Classical_Monocyte-Mono_c3-CD14-VCAN\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	571accef38f5b03a7e032495d5c6d25d27073428
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Classical_Monocyte-Mono_c1-CD14-CCL3\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	cd93e8947bcf3c2d7e6d5bfd70300145fba15f74
ToppCell	3'_v3-bone_marrow-Myeloid_Monocytic\|bone_marrow / Manually curated celltypes from each tissue	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	51a766f823a9d50a3b1d59d0df2f5241a6b44c2b
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 TRIO RABGAP1L RERE DMD	1.09e-04	199	105	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TET2 CDC42BPA CEP290 GOLGB1 ZNF292	1.09e-04	199	105	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	COVID-19-lung\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DMXL2 RNF213 LRP1 IRAK3 ARAP2	1.09e-04	199	105	5	155b03b859157013e9142e9248551369127d9204
ToppCell	10x5'-bone_marrow-Myeloid_Monocytic-Classical_monocytes\|bone_marrow / Manually curated celltypes from each tissue	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	2c747e9265594e12d46bd8c8de75c45e83144155
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	dbf0bf09896c46155ae6fbd6307f097799e7e34e
ToppCell	3'_v3-bone_marrow-Myeloid_Monocytic-Classical_monocytes\|bone_marrow / Manually curated celltypes from each tissue	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	93f25e8f22deb438c930c2e95e572dbd16503f71
ToppCell	severe_influenza-Classical_Monocyte\|severe_influenza / disease group, cell group and cell class (v2)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.09e-04	199	105	5	899d9fa9e3d97e876da27674de89c33bff1affe9
ToppCell	Sepsis-Int-URO-Myeloid-CD14+_Monocyte\|Int-URO / Disease, condition lineage and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	7471a202c36800f488a738c6803d9fb3fe167aad
ToppCell	COVID_vent-Myeloid\|COVID_vent / Disease condition, Lineage, Cell class and subclass	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	621af09aae34226902c03edf556562f3ab35a7d8
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 DMXL2 LRRK2 LRP1 IRAK3	1.11e-04	200	105	5	934c2efc780318c66d667ca75be0de350361d351
ToppCell	mild-Classical_Monocyte\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	7beafb86fd77b022bd0549c8642a630937e364c3
ToppCell	facs-Brain_Non-Myeloid-Hippocampus\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDC42BPA CLPTM1 MYRF ARAP2 DNM2	1.11e-04	200	105	5	fc28f71ca1cd0fdae66009ae5afe175d22f2bd8c
ToppCell	severe-Classical_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	ce03be0ccfc22eb923302a2ad73b39752e888270
ToppCell	COVID-19-COVID-19_Severe-Myeloid-CD14+_Monocyte\|COVID-19_Severe / Disease, condition lineage and cell class	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	6abee30708572519045e9456dac2017b5308817a
ToppCell	COVID_vent-Myeloid-Monocytic-CD14+_Monocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	e57452b73abb21cb3f645d45523ab93f6bef0243
ToppCell	COVID_non-vent-Myeloid-Monocytic-CD14+_Monocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	465ed50e0b92bb8c27ffe56d816f063a45b52be9
ToppCell	COVID_vent-Myeloid-Monocytic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	b0a5bee87700ce38f26f95a6f491da7e27cade51
ToppCell	COVID-19-COVID-19_Convalescent-Others-Platelet\|COVID-19_Convalescent / Disease, condition lineage and cell class	ZNF438 VEPH1 CLU PDE5A DMD	1.11e-04	200	105	5	5547e7173293fce403706f69331ce3976da73a32
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Monocytic-Classical_Monocyte\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DMXL2 LRRK2 CLU LRP1 IRAK3	1.11e-04	200	105	5	933db31e61e08ccf31105b3d3cf85c8d42c8174d
Drug	Pronethalol hydrochloride [51-02-5]; Down 200; 15uM; MCF7; HT_HG-U133A	TRAF6 TRIO CEP290 PPP6R1 ARHGEF16 LIMK1 PPP5C DNM2	3.08e-06	194	104	8	7322_DN
Drug	Gabexate mesilate [56974-61-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A	VPS50 ELOVL5 RAP1GAP2 LIMK1 NEUROD1 CLU RERE PDE11A	3.58e-06	198	104	8	7357_UP
Drug	Magnetite Nanoparticles	TET2 USP34 ATP7A CDC42BPA VPS50 MMP23B RNF213 TMEM38B PRDM2 CASK TTC7A CCNT2 UBA7 CLU STARD9 LRP1 FBXO15 MBNL3 ZNF292	6.74e-06	1310	104	19	ctd:D058185
Disease	Focal Cortical Dysplasia of Taylor, Type IIb	TSC2 MTOR	3.75e-05	3	105	2	C1846389
Disease	FOCAL CORTICAL DYSPLASIA OF TAYLOR	TSC2 MTOR	3.75e-05	3	105	2	C1846385
Disease	Focal Cortical Dysplasia of Taylor, Type IIa	TSC2 MTOR	3.75e-05	3	105	2	C1846386
Disease	Isolated focal cortical dysplasia type II	TSC2 MTOR	3.75e-05	3	105	2	cv:C1846385
Disease	FOCAL CORTICAL DYSPLASIA, TYPE II	TSC2 MTOR	3.75e-05	3	105	2	607341
Disease	isolated growth hormone deficiency type II (implicated_via_orthology)	CSH1 CSH2	1.25e-04	5	105	2	DOID:0060872 (implicated_via_orthology)
Disease	Colorectal Carcinoma	TET2 AMPD1 ABCA4 KALRN LRRC4 TOMM40L LRP1 CTBP1 DMD ZNF292	2.06e-04	702	105	10	C0009402
Disease	isolated growth hormone deficiency (implicated_via_orthology)	CSH1 CSH2	2.60e-04	7	105	2	DOID:0060870 (implicated_via_orthology)
Disease	level of Phosphatidylethanolamine (O-18:2_20:4) in blood serum	CLPTM1 MYRF	3.46e-04	8	105	2	OBA_2045151
Disease	type 1 diabetes mellitus (implicated_via_orthology)	CSH1 CSH2 IRAK3	3.65e-04	39	105	3	DOID:9744 (implicated_via_orthology)
Disease	Moyamoya disease	RNF213 LRP1 MYRF	3.93e-04	40	105	3	MONDO_0016820
Disease	mortality	GALNTL6 RAP1GAP2 CCDC148 DMD ARAP2	3.93e-04	173	105	5	EFO_0004352
Disease	Thyroid carcinoma	TSC2 PRDM2 MTOR	5.22e-04	44	105	3	C0549473
Disease	Muscle Weakness	AMPD1 DMD	5.54e-04	10	105	2	C0151786
Disease	cystic kidney disease (implicated_via_orthology)	CEP290 DNM2	5.54e-04	10	105	2	DOID:2975 (implicated_via_orthology)
Disease	level of Phosphatidylethanolamine (O-18:1_20:4) in blood serum	CLPTM1 MYRF	5.54e-04	10	105	2	OBA_2045148
Disease	cerebral cavernous malformation (implicated_via_orthology)	CDC42BPA RNF213	6.76e-04	11	105	2	DOID:0060669 (implicated_via_orthology)
Disease	Crohn's disease	GALNTL6 USP34 KALRN LRRK2 SMURF1 PPP5C MYRF	1.03e-03	441	105	7	EFO_0000384
Disease	congenital hypothyroidism (biomarker_via_orthology)	CSH1 CSH2	1.11e-03	14	105	2	DOID:0050328 (biomarker_via_orthology)
Disease	Seizures	ATP7A TSC2 DEGS1 CLU ZNF292	1.12e-03	218	105	5	C0036572
Disease	Anilide use measurement	RABGAP1L LRP1	1.28e-03	15	105	2	EFO_0009938
Disease	Malignant neoplasm of breast	ZNF438 ABCA4 KALRN GRM6 NLRP14 MTOR NHS LRRC7 DMD GOLGB1 FOXP3	1.55e-03	1074	105	11	C0006142
Disease	Moyamoya Disease	ATP7A RNF213	1.65e-03	17	105	2	C0026654
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TRIO ZNF292	1.65e-03	17	105	2	DOID:0060307 (is_implicated_in)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	TET2 LRRK2 TSC2 MTOR	1.96e-03	148	105	4	C0279702
Disease	portal hypertension (implicated_via_orthology)	MTOR NR1H4	2.06e-03	19	105	2	DOID:10762 (implicated_via_orthology)
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	OBSL1 MYRF	2.06e-03	19	105	2	EFO_0004612, EFO_0008589
Disease	family history of Alzheimer’s disease	ADAMTS4 CLU CLPTM1	2.10e-03	71	105	3	EFO_0009268
Disease	glucose measurement	TET2 FBRSL1 FOXA2 NEUROD1 SNAP91 CTBP1	2.42e-03	380	105	6	EFO_0004468
Disease	reaction time measurement	TET2 LRRK2 FBRSL1 RAP1GAP2 SNAP91 RABGAP1L RERE DNM2	2.46e-03	658	105	8	EFO_0008393
Disease	venous thromboembolism, plasminogen activator inhibitor 1 measurement	CKAP5 ZNF160	2.52e-03	21	105	2	EFO_0004286, EFO_0004792
Disease	osteoporosis (biomarker_via_orthology)	CSH1 CSH2	2.77e-03	22	105	2	DOID:11476 (biomarker_via_orthology)
Disease	type 2 diabetes mellitus (is_implicated_in)	CYP11B2 FOXA2 NEUROD1 MTOR	3.30e-03	171	105	4	DOID:9352 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ALRSQAQHQLHAAMF	FBRSL1	366	Q9HCM7
LHVNDASHNHHSKMS	CCNT2	621	O60583
QHSHPHIEFNSMKVL	CCDC148	146	Q8NFR7
EHNHHLINDFTVKQM	CTBP1	241	Q13363
HNILFHHLTVAEHML	ABCA4	1011	P78363
HHLTVAEHMLFYAQL	ABCA4	1016	P78363
LRATVTQMEHHHLFS	ARHGEF16	316	Q5VV41
TQMEHHHLFSNILDV	ARHGEF16	321	Q5VV41
INHMNAHNLALVFSS	ARAP2	1256	Q8WZ64
HHEMQAHIFHLETLS	AMPD1	51	P23109
TTHHLMVHGNERFIQ	SNAP91	81	O60641
MHEVQRHISHHANAL	DMXL2	341	Q8TDJ6
TKEEHFQLHHQMHYS	DMD	261	P11532
DHQHMLHSYITDLFQ	ARMC10	211	Q8N2F6
HHFATLHHNQNMSKE	ATP7A	676	Q04656
QKFHRHMIDLSHINV	RBM33	1151	Q96EV2
LQHMHHDAILASSAR	INTS7	201	Q9NVH2
LTELRTFNHHHAEML	NR1H4	451	Q96RI1
NEYISHREHIHMNAT	KIN	96	O60870
LSMAQDGHIHRLFIH	OBSL1	1496	O75147
HFMALLQTHDVVAHE	CASK	436	O14936
AILNQLTTIHMHSHS	HSFY1	291	Q96LI6
HFMHQLSTVDAHART	FOXP3	101	Q9BZS1
LQANGHSFVHMEHEK	LRRC7	1501	Q96NW7
NHQITVLHVYHHASM	ELOVL5	136	Q9NYP7
HTINISLSLHHVEQM	LRP1	271	Q07954
FDHAMLQAHRAHQLA	CSH2	36	P0DML3
LTLQHFQHMHIKVGD	HTD2	26	P86397
ATLEHHHFNHAVMIL	PDE11A	731	Q9HCR9
HHFNHAVMILQSEGH	PDE11A	736	Q9HCR9
MEHHHFDQCLMILNS	PDE5A	681	O76074
EMQDLELAIHHHQTL	KALRN	446	O60229
YLVSQLANMEHSFHH	VEPH1	311	Q14D04
NIQMIQADTFRHLHH	LRRC4	86	Q9HBW1
LVHHSFDLVIFHQMS	LRRK2	666	Q5S007
DFAMAHFRSHLEHQS	IRAK3	311	Q9Y616
HFRSHLEHQSCTINM	IRAK3	316	Q9Y616
HLMINNTKAFIHHEL	DNM2	681	P50570
LLNLFHAMEGISHLH	GREB1L	1531	Q9C091
LHSHFSDLNLEAHMY	RABGAP1L	681	Q5R372
EMFHSDFQHHNKALA	CKAP5	1211	Q14008
DFQHHNKALAVMVDH	CKAP5	1216	Q14008
HELGHVFNMLHDNSK	ADAMTS4	361	O75173
DAVYAIAHALHSMHQ	GRM6	406	O15303
HQFNIDSMVHKHGLE	PRMT3	71	O60678
SHHTLKIAHQTIANM	CEP290	1531	O15078
EEELAFVMANLHFHH	FBXO15	306	Q8NCQ5
FVMANLHFHHLVERS	FBXO15	311	Q8NCQ5
NHSMTLAIHEIAHNA	DEGS1	81	O15121
HHQMNHSAASAMALQ	MBNL3	246	Q9NUK0
MNSSFHLHFLDLNLN	MC5R	1	P33032
VMHEALHNHYTQKSL	IGHG2	306	P01859
YEHLHLEMHQTFQEL	CYP11B2	61	P19099
HTRQHCSLFDVSHML	AMT	71	P48728
MEHTHAHLAANSSLS	GPR139	1	Q6DWJ6
FDHAMLQAHRAHQLA	CSH1	36	P0DML2
RSHLHDTFTQMTHAL	SPACA6	76	W5XKT8
IHMLTHLAEALHQAR	CHID1	206	Q9BWS9
NDLTLTLSNHMSFHA	HELB	316	Q8NG08
ERHMHIHISTVNHAF	PRDM2	376	Q13029
HLVHMASFSAQTNMH	ARHGAP30	151	Q7Z6I6
DQSLSHHHTMVVQAI	MTOR	961	P42345
FSINNLMSSEQQHHH	FOXA2	376	Q9Y261
HINMTVLEKFNHHAN	GALNTL6	586	Q49A17
LDNLHDELHAHTQAM	RAP1GAP2	461	Q684P5
VSNQFKHQFVMSRHH	NHS	1336	Q6T4R5
HSQHGRALMHLNATL	MMP23B	221	O75900
VHDSQAFISHHLNML	TAF2	1051	Q6P1X5
HFHLLRGNHETDNMN	PPP5C	296	P53041
RLQMFNVTPHHHQHS	RERE	1416	Q9P2R6
SMHNLSLHLSQLLHS	STARD9	3676	Q9P2P6
TATHLQLALNFTAHM	MRPS2	121	Q9Y399
HSNDHTLSFIAHQPM	CDC42BPA	1396	Q5VT25
TTQFTDPRLHHIMNH	SMURF1	331	Q9HCE7
TLMNLHVYISEHEHF	CLPTM1	101	O96005
SNLFLHLRATHHMTE	LINC02915	46	Q8N8G6
IHEAQQAMDIHFHSP	CLU	251	P10909
ASISHFMQFPHHLQE	CNOT1	976	A5YKK6
TITHSAHMDIFQNLA	CNOT1	2241	A5YKK6
QHVSMEFLKLHQFLH	TRIM69	201	Q86WT6
FHEHSAMLLAQLNAF	RNF213	2651	Q63HN8
TQMAVLAAQHHHSRA	TNRC18	521	O15417
DQLHMHFTQAIHNTV	VPS50	271	Q96JG6
AFTHRSSFIQHNMTH	ZNF599	291	Q96NL3
AAFHTASSEMGHQQH	ZNF143	571	P52747
ASSEMGHQQHSHHLV	ZNF143	576	P52747
AFSMHSNLATHQVIH	ZNF160	461	Q9HCG1
MAAAEAVHHIHLQNF	ZBTB45	1	Q96K62
NHHQQAHTSLADMDE	UBA7	631	P41226
IFNPEHHHVHQDMTQ	PLCH2	316	O75038
NHLARHLQENTQSHM	TRAF6	256	Q9Y4K3
DFNGHSALIRHQMIH	ZNF398	491	Q8TD17
FVSVTHLNDHLQMHC	ZNF292	731	O60281
QHTQHLAISKHNLMF	TMEM38B	196	Q9NVV0
KNMVDLVNTHHLHSS	PPP6R1	516	Q9UPN7
ETENGLLALMHHSNH	USP24	2476	Q9UPU5
LLALMHHSNHVDSSR	USP24	2481	Q9UPU5
LSSHFQVAHTIHMSA	TOMM40L	56	Q969M1
HHQHALDVVNMAITE	TTC7A	581	Q9ULT0
NELDQHGHIILNSMH	TBX20	211	Q9UMR3
FSQSMHLIVHQRSHT	ZFP2	251	Q6ZN57
HSRGLFSHMQQHDIL	USP34	3506	Q70CQ2
DFCAHAHRDLHNMQN	TET2	1376	Q6N021
AFANSSHLTVHMRTH	ZNF559	361	Q9BR84
FQFKQHLRDHMNTHT	ZNF438	516	Q7Z4V0
AFMNSSSLLNHHKVH	ZNF485	166	Q8NCK3
HAMELQTQHNHFAMN	TRIO	376	O75962
ALHANMASQVHHSRS	TSC2	1716	P49815
RKLSFHNLQEEMHHL	GOLGB1	331	Q14789
HLVKSHTNTSHVMQY	LGMN	256	Q99538
LHSMNIIHRDLNSHN	LIMK1	451	P53667
YHSNLDKSAMNILHH	NLRP14	681	Q86W24
TDLHHTQQSQMLHQL	MYRF	226	Q9Y2G1
FDSHSHHERVMSAQL	NEUROD1	336	Q13562
HHERVMSAQLNAIFH	NEUROD1	341	Q13562