Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncytoskeletal motor activity

CENPE DYNC2H1 MYO1H KIF21A KIF19

2.57e-05118595GO:0003774
GeneOntologyMolecularFunctionmicrotubule motor activity

CENPE DYNC2H1 KIF21A KIF19

5.45e-0570594GO:0003777
GeneOntologyMolecularFunctionATP-dependent activity

CENPE DYNC2H1 TMEM94 MYO1H KIF21A KIF19 FANCM POLQ

4.25e-04614598GO:0140657
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

ASAP2 PLAA DIABLO APAF1 ASAP3 DOCK10 DAPK1 PLEK FAS ASAP1

1.36e-064995910GO:0051345
GeneOntologyBiologicalProcesspositive regulation of catalytic activity

ASAP2 PLAA CENPE DIABLO PIK3CG APAF1 ASAP3 DOCK10 DAPK1 PLEK FAS ASAP1

2.81e-0510285912GO:0043085
GeneOntologyBiologicalProcessregulation of hydrolase activity

ASAP2 PLAA DIABLO CSTL1 APAF1 ASAP3 DOCK10 DAPK1 PLEK FAS ASAP1

3.36e-058785911GO:0051336
DomainWD40

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

1.76e-07268609SM00320
DomainWD40_repeat

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

1.99e-07272609IPR001680
DomainWD_REPEATS_1

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

2.40e-07278609PS00678
DomainWD_REPEATS_2

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

2.47e-07279609PS50082
DomainWD_REPEATS_REGION

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

2.47e-07279609PS50294
DomainWD40_repeat_dom

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

4.18e-07297609IPR017986
DomainPH

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

6.68e-07229608PF00169
Domain-

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

1.09e-063336092.130.10.10
DomainWD40/YVTN_repeat-like_dom

NWD2 PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

1.14e-06335609IPR015943
DomainWD40

PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

1.68e-06259608PF00400
DomainPH

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

2.85e-06278608SM00233
DomainPH_DOMAIN

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

2.93e-06279608PS50003
DomainPH_domain

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

3.01e-06280608IPR001849
Domain-

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

3.39e-053916082.30.29.30
DomainPH_dom-like

DOK6 ASAP2 AFAP1 ASAP3 OSBPL6 DOCK10 PLEK ASAP1

6.21e-05426608IPR011993
DomainArfGap

ASAP2 ASAP3 ASAP1

1.09e-0429603SM00105
DomainArfGap

ASAP2 ASAP3 ASAP1

1.09e-0429603PF01412
DomainARFGAP

ASAP2 ASAP3 ASAP1

1.09e-0429603PS50115
DomainArfGAP

ASAP2 ASAP3 ASAP1

1.09e-0429603IPR001164
Domain-

ASAP2 ASAP3 ASAP1

1.20e-04306031.20.1270.60
DomainAH/BAR-dom

ASAP2 ASAP3 ASAP1

1.20e-0430603IPR027267
DomainG-protein_beta_WD-40_rep

RRP9 APAF1 WDR5 THOC3

1.60e-0485604IPR020472
DomainWD40_repeat_CS

NWD2 RRP9 KIF21A APAF1 WDR5

1.82e-04164605IPR019775
DomainKinesin_motor_CS

CENPE KIF21A KIF19

3.08e-0441603IPR019821
DomainKinesin-like_fam

CENPE KIF21A KIF19

3.55e-0443603IPR027640
DomainKINESIN_MOTOR_1

CENPE KIF21A KIF19

3.80e-0444603PS00411
Domain-

CENPE KIF21A KIF19

3.80e-04446033.40.850.10
DomainKinesin_motor_dom

CENPE KIF21A KIF19

3.80e-0444603IPR001752
DomainKinesin

CENPE KIF21A KIF19

3.80e-0444603PF00225
DomainKINESIN_MOTOR_2

CENPE KIF21A KIF19

3.80e-0444603PS50067
DomainKISc

CENPE KIF21A KIF19

3.80e-0444603SM00129
DomainAnk_2

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

6.30e-04215605PF12796
DomainAnk

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

8.21e-04228605PF00023
Domain-

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.19e-032486051.25.40.20
DomainANK

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.26e-03251605SM00248
DomainANK_REPEAT

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.30e-03253605PS50088
DomainAnkyrin_rpt-contain_dom

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.33e-03254605IPR020683
DomainANK_REP_REGION

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.33e-03254605PS50297
DomainP-loop_NTPase

NWD2 CENPE DYNC2H1 KIF21A KIF19 APAF1 DAPK1 FANCM POLQ

1.45e-03848609IPR027417
DomainAnkyrin_rpt

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

1.52e-03262605IPR002110
Domain-

APAF1 DAPK1 FAS

3.33e-03936031.10.533.10
DomainDEATH

DAPK1 FAS

3.38e-0327602SM00005
DomainDEATH-like_dom

APAF1 DAPK1 FAS

3.97e-0399603IPR011029
DomainDeath

DAPK1 FAS

5.03e-0333602PF00531
DomainDeath_domain

DAPK1 FAS

6.62e-0338602IPR000488
DomainDEATH_DOMAIN

DAPK1 FAS

6.62e-0338602PS50017
PathwayWP_NANOMATERIAL_INDUCED_APOPTOSIS

DIABLO APAF1 FAS

3.12e-0520443M39479
PathwayWP_RELATIONSHIP_BETWEEN_INFLAMMATION_COX2_AND_EGFR

PLA1A PIK3CG PTGER3

6.22e-0525443M39794
PathwayKEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS

ASAP2 PIK3CG ASAP3 ASAP1

2.23e-0496444M16121
PathwayREACTOME_SMAC_XIAP_REGULATED_APOPTOTIC_RESPONSE

DIABLO APAF1

2.63e-048442M26908
PathwayREACTOME_FORMATION_OF_APOPTOSOME

DIABLO APAF1

4.22e-0410442MM14485
PathwayREACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION

CENPE KIF21A KIF19 DOCK10

4.58e-04116444MM15715
PathwayREACTOME_FORMATION_OF_APOPTOSOME

DIABLO APAF1

5.14e-0411442M41721
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS

APAF1 FAS

5.14e-0411442M47693
PathwayREACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE

DIABLO APAF1

6.16e-0412442MM14487
PathwayREACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE

DIABLO APAF1

7.27e-0413442M26907
PathwayREACTOME_KINESINS

CENPE KIF21A KIF19

7.38e-0457443MM15714
PathwayBIOCARTA_HSP27_PATHWAY

APAF1 FAS

8.46e-0414442M2587
PathwayBIOCARTA_HSP27_PATHWAY

APAF1 FAS

8.46e-0414442MM1503
PathwayREACTOME_KINESINS

CENPE KIF21A KIF19

9.00e-0461443M977
PathwayKEGG_MEDICUS_REFERENCE_CROSSTALK_BETWEEN_EXTRINSIC_AND_INTRINSIC_APOPTOTIC_PATHWAYS

APAF1 FAS

9.74e-0415442M47448
Pubmed

Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.

DIABLO APAF1 FAS

1.07e-07662317603079
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C KDM5B WDR5

1.52e-061362321502505
Pubmed

Prostaglandin E1 attenuates AngII-induced cardiac hypertrophy via EP3 receptor activation and Netrin-1upregulation.

NTN1 PTGER3

3.13e-06262234147480
Pubmed

Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications.

APAF1 DAPK1

3.13e-06262216951219
Pubmed

ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.

ASAP3 ASAP1

3.13e-06262218400762
Pubmed

Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2.

PIK3CG PTGER3

3.13e-06262236245399
Pubmed

Methylation of the APAF-1 and DAPK-1 promoter region correlates with progression of renal cell carcinoma in North Indian population.

APAF1 DAPK1

9.37e-06362221922274
Pubmed

Evidence for the stochastic integration of gene trap vectors into the mouse germline.

APAF1 NTN1

9.37e-0636229092658
Pubmed

Role of Methylation in the Regulation of Apoptosis Genes APAF1, DAPK1, and BCL2 in Breast Cancer.

APAF1 DAPK1

9.37e-06362228429233
Pubmed

Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.

ASAP2 ASAP3 ASAP1

1.53e-052762318685082
Pubmed

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

APAF1 FAS

1.87e-0546229267021
Pubmed

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.

APAF1 FAS

1.87e-05462215118096
Pubmed

PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins.

DIABLO APAF1

1.87e-05462223207240
Pubmed

Immunohistochemical Aspects of Cell Death in Diabetic Nephropathy.

APAF1 FAS

1.87e-05462227141571
Pubmed

Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.

MYLK DYNC2H1

1.87e-05462226147384
Pubmed

Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.

ASAP2 ASAP1

1.87e-05462212149250
Pubmed

XIAP activity dictates Apaf-1 dependency for caspase 9 activation.

DIABLO APAF1

3.12e-05562217562856
Pubmed

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis.

DIABLO APAF1

3.12e-05562211242052
Pubmed

Diversification of stem cell molecular repertoire by alternative splicing.

BRIX1 APAF1 ASAP1

3.39e-053562316183747
Pubmed

All kinesin superfamily protein, KIF, genes in mouse and human.

CENPE KIF21A KIF19

4.01e-053762311416179
Pubmed

Essential postmitochondrial function of p53 uncovered in DNA damage-induced apoptosis in neurons.

DIABLO APAF1

4.67e-05662217218959
Pubmed

C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase.

PIK3CG DAPK1

4.67e-05662220018188
Pubmed

Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF.

ASAP2 ASAP1

4.67e-05662218786926
Pubmed

Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis.

DIABLO FAS

4.67e-05662212011074
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C WDR5

4.67e-05662217021013
Pubmed

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

ASAP2 ASAP1

6.53e-0576229819391
Pubmed

CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.

ASAP2 ASAP1

6.53e-05762217255943
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2C WDR5

6.53e-05762230604749
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C WDR5

6.53e-05762219433796
Pubmed

Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth.

APAF1 NTN1

6.53e-05762215105372
Pubmed

FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.

HIPK1 FAS

6.53e-05762211034606
Pubmed

Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.

KMT2C WDR5

6.53e-05762226324722
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

KDM5B DIABLO DYNC2H1 USP28 PIK3CG KLHL23 BARD1 THOC3 DCAF4

6.96e-05100562919615732
Pubmed

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.

PIK3CG ZHX2

8.69e-05862221909108
Pubmed

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.

ASAP2 ASAP1

8.69e-05862215719014
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2C WDR5

8.69e-05862222266653
Pubmed

Knockdown of miR-182 promotes apoptosis via regulating RIP1 deubiquitination in TNF-α-treated triple-negative breast cancer cells.

DIABLO APAF1

8.69e-05862227476169
Pubmed

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.

APAF1 FAS

8.69e-05862224632563
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TMEM94 HIPK1 ZNF451 DOCK10 ZHX2 ASAP1

8.75e-0540762612693553
Pubmed

Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system.

KLHL23 DCAF4 PDZRN3 DCAF4L1

1.11e-0413862428786561
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2C WDR5

1.12e-04962222665483
Pubmed

Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.

KDM5B ZNF451 DAPK1 THOC3 LY75 PDZRN3

1.21e-044326267671812
Pubmed

Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1.

APAF1 DAPK1

1.70e-041162215001356
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2C WDR5

2.04e-041262227563068
Pubmed

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.

ASAP2 ASAP1

2.04e-041262235192416
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C WDR5

2.41e-041362217761849
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KMT2C KDM5B

2.41e-041362224619213
Pubmed

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.

PLAA WDR5

2.81e-041462221070969
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C WDR5

3.23e-041562217925232
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

KMT2C AFAP1 USP28 KIF21A TMEM131L PCNX1

3.60e-0452962614621295
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2C WDR5

3.69e-041662223870121
Pubmed

HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.

PIK3CG FAS

3.69e-041662216524887
Pubmed

Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development.

NTN1 PTGER3

3.69e-041662228439006
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

CYP2C9 PIK3CG APAF1 BARD1 FAS

4.11e-0435162520453000
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2C WDR5

4.18e-041762226180087
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2C9 ZHX2

4.18e-041762227197076
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2C WDR5

4.70e-041862217500065
Pubmed

Jmjd5 functions as a regulator of p53 signaling during mouse embryogenesis.

APAF1 FAS

4.70e-041862226334721
Pubmed

Impact of ancestry and common genetic variants on QT interval in African Americans.

OSBPL6 PDZRN3

5.24e-041962223166209
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

KMT2C ASAP2 DOCK10 POLQ

5.29e-0420862433230847
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C WDR5

5.82e-042062229785026
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2C WDR5

5.82e-042062219047629
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CENPE DYNC2H1 USP28 HIPK1 ZNF451 THOC3

6.27e-0458862638580884
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2C KDM5B

6.42e-042162227626377
Pubmed

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.

KDM5B ASAP1

6.42e-042162224859337
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

ZNF451 BARD1 WDR5 POLQ

6.74e-0422262437071664
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2C WDR5

7.06e-042262226886794
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

KMT2C APAF1 DOCK10 PCNX1

7.09e-0422562412168954
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

HIPK1 KIF21A DOCK10

8.17e-041026239734811
Pubmed

MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis.

FAS PDZRN3

8.41e-042462224931612
Pubmed

Expression of Fas, FasL, caspase-8 and other factors of the extrinsic apoptotic pathway during the onset of interdigital tissue elimination.

DAPK1 FAS

8.41e-042462227709293
Pubmed

Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction.

CA12 PLA1A LY75

8.88e-0410562324667918
Pubmed

A protein interaction landscape of breast cancer.

BRIX1 PLAA DIABLO USP28 RRP9 BARD1

9.27e-0463462634591612
Pubmed

No death without life: vital functions of apoptotic effectors.

DIABLO APAF1

9.89e-042662218309324
Pubmed

A three-stage genome-wide association study of general cognitive ability: hunting the small effects.

WDR5 PDZRN3

1.23e-032962220306291
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

KMT2C USP28 WDR5

1.28e-0311962323508102
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

USP28 ZNF451 BARD1 FANCM ZHX2

1.29e-0345362529656893
Pubmed

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

SORCS2 ZHX2

1.32e-033062220080650
Pubmed

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.

CLCN5 USP28

1.32e-033062228077597
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

KMT2C WDR5

1.41e-033162220516061
Pubmed

The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.

KDM5B PCNX1

1.59e-033362219336002
Pubmed

Genome-wide association study of antibody response to smallpox vaccine.

CYP2C9 ZHX2

1.69e-033462222542470
Pubmed

Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.

APAF1 BARD1

1.69e-033462212549820
Pubmed

A human MAP kinase interactome.

KMT2C ASAP2 HIPK1 ZNF451 ASAP1

1.76e-0348662520936779
GeneFamilyWD repeat domain containing

PLAA RRP9 KIF21A APAF1 WDR5 THOC3 DCAF4 DCAF4L1

6.49e-07262518362
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOK6 ASAP2 AFAP1 ASAP3 DOCK10 PLEK ASAP1

1.70e-06206517682
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP2 ASAP3 ASAP1

1.40e-05175131291
GeneFamilyArfGAPs

ASAP2 ASAP3 ASAP1

1.09e-0433513395
GeneFamilyKinesins|Pleckstrin homology domain containing

CENPE KIF21A KIF19

2.95e-0446513622
GeneFamilyAnkyrin repeat domain containing

ASAP2 ASAP3 BARD1 DAPK1 ASAP1

5.86e-04242515403
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SLC12A3 PLA1A DOCK10 PLEK LY75

4.81e-06177625ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ASAP2 SLC12A3 DYNC2H1 PTGER3

5.08e-06179625666072c0e8448dbaec1683d18368ec2502453f90
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ASAP2 SLC12A3 DYNC2H1 PTGER3

5.50e-061826255f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell10x5'v1-week_12-13-Hematopoietic-MK-MK|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DOK6 ASAP2 MYLK PLEK PTGER3

5.65e-061836256cbc88c27dc957d182526e84824f70c8e860bf74
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ASAP2 SLC12A3 DYNC2H1 PTGER3

5.65e-061836252e831a4d99c6f983793df71c0994124c943c6da9
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RRP9 KIF21A SORCS2 SLC34A2 DAPK1

5.80e-0618462542ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A HIPK1 RRP9 KIF21A SLC34A2

5.80e-06184625157a3d00165bb4a8c52c3e63ae57d9cf57500be7
ToppCell10x3'2.3-week_17-19-Hematopoietic-MK-MK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DOK6 ASAP2 MYLK PLEK PTGER3

5.80e-06184625ba65e3972b2b8d825a2c1a9d03d092cc1afad073
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

KMT2C HIPK1 DOCK10 TMEM131L PCNX1

6.44e-06188625ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ASAP2 SLC12A3 DYNC2H1 PTGER3

6.61e-061896257eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCell10x3'2.3-week_17-19-Hematopoietic-MK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DOK6 ASAP2 MYLK PLEK PTGER3

6.78e-0619062564060e4b56ac9989e659c2d5d2a6b6edeba4d8d4
ToppCell10x5'v1-week_14-16-Hematopoietic-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DOK6 ASAP2 MYLK PLEK PTGER3

6.96e-061916257edc22e7e70697fb22690699efb352577162709b
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

KMT2C HIPK1 DOCK10 TMEM131L PCNX1

7.14e-0619262547646d7e4990be85072987f92bf18d52f8da752e
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KMT2C DAPK1 PCNX1 ZHX2 ASAP1

7.32e-06193625779276e775cb2492e8dd36436295a536084a6415
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 CLCN5 DYNC2H1 PTGER3

7.69e-06195625a38d9dc6192aea673d96fda6b25e81223fda3abf
ToppCell10x3'2.3-week_14-16-Hematopoietic-MK-MK|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ASAP2 AFAP1 MYLK PLEK PTGER3

7.89e-0619662566ba31b74953726e9c314f6d8fe3f75d3762e23a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

DOK6 MYLK DOCK10 DAPK1 PDZRN3

8.08e-0619762511a4c417f035e554431a8f03be13b5eefa3530c0
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_1-2_Progenitor-Progenitor_AT1-AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PLA1A RRP9 KIF21A SLC34A2 DAPK1

8.28e-0619862550852713c017217c79777c95857097103bcf2fbe
ToppCellTracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLC12A3 DOCK10 DAPK1 PLEK LY75

8.49e-061996257b3d4c62b11268c7c1599600d8a7b331287cf21a
ToppCellLPS_IL1RA_TNF-Epithelial_alveolar|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PLA1A RRP9 KIF21A SLC34A2 DAPK1

8.70e-06200625c89f3cb36bb14c476d6a392bfd3ded1c8feecfeb
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CENPE TMEM94 RRP9 KLHL23

6.47e-051556245687416773809b8c478567bc54310af102b3029a
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 CLCN5 PTGER3

6.63e-051566244d2679e7639758c49fc25a2deb9109b08f0a3e57
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

6.80e-05157624c17c5c01fcb65c453690c265ec4f300ecdfefd34
ToppCellBronchial-10x5prime-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

MYLK OSBPL6 NTN1 PDZRN3

7.14e-051596247cda111bb98f1241989e49d490bdf51a712ea589
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 KIF19 ASAP3

7.32e-051606248bcdbcfdf1e0ace6053e8de82762f6e2f86bba7a
ToppCellAdult-Mesenchymal-airway_smooth_muscle_cell-D231|Adult / Lineage, Cell type, age group and donor

PCSK1 MYLK NTN1 PDZRN3

7.32e-05160624d783d29150033e9181c0e30870070268fed3fd85
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 KIF19 ASAP3

7.32e-051606242d391ba6f7adb55dfa89feecc10cc9ce97e5fe74
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 NTN1 PTGER3

7.32e-051606241e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCellPND01-03-samps-Myeloid-Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

PIK3CG DOCK10 PLEK LY75

8.05e-0516462449733a9d3d95f05056b5b01916060ff20a8de3cf
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DOK6 KLHL23 PTGER3 PDZRN3

8.44e-051666246d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DOK6 DOCK10 PCNX1 THOC3

8.64e-0516762483969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCellImmune-dendritic_cell|World / Lineage, Cell type, age group and donor

SLC12A3 PIK3CG DOCK10 PLEK

9.46e-051716246a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

9.68e-051726241565f38266891c3acf49778838de134c5dee5460
ToppCell10x5'-bone_marrow-Hematopoietic_Erythro-Mega-Erythrocytic-Meg|bone_marrow / Manually curated celltypes from each tissue

ASAP2 MYLK PLEK PTGER3

9.68e-05172624deda14ba1e760dd46a5e129683d415436e74deb6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PIK3CG DOCK10 PLEK ASAP1

9.90e-0517362473f858f2c45d19b9ec8d99ac02c91551790f670c
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA1A BARD1 TMEM131L LY75

1.01e-041746247be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 LY6L NTN1 PTGER3

1.01e-04174624d81a5e767e8882ebca4678af881c94c062f8cea5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CENPE BARD1 PLEK POLQ

1.01e-041746247b318796728001c17b4043d2b033330c7be40c78
ToppCellsaliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CLCN5 KLHL23 DAPK1 PLEK

1.01e-04174624d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.01e-041746245f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCelldroplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLA1A BARD1 TMEM131L LY75

1.03e-041756241b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.03e-0417562477c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPE ZNF165 BARD1 POLQ

1.03e-04175624876cea684faf42ff3eb4623ad6d7a1fb1276ee02
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.06e-0417662425ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 KIF21A NTN1 PTGER3

1.06e-04176624c2c4306476989bc2fb30dab00250ef7915842f13
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 KIF21A NTN1 PTGER3

1.08e-041776248e4005fad50e6f919da175f3b9ae58849dbd60b1
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE DOCK10 PLEK LY75

1.08e-0417762467cc3a6461db5e0678f96b18224aeb83ad34b0f4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.10e-04178624dfed0fbf7a73b8a9e00178ec58dc4592b271c344
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.13e-04179624e6ae070b4c52ba08167c7d64ea4cfbac0454c1bf
ToppCelldroplet-Bladder-Unstain-18m-Epithelial-granulocyte-monocyte_progenitor|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CENPE BARD1 POLQ PTGER3

1.13e-04179624804aa3899585fc7e662eff9f6d41f48655f16dd6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.13e-04179624d0fa700648db8ce76a8aa689879a25048299fa40
ToppCell10x5'v1-week_17-19-Hematopoietic-MK-early_MK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

DOK6 MYLK PLEK PTGER3

1.13e-04179624d5b9c610c1519804b1753fed1b505293ea590867
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.13e-041796242e49b215b71438400aebb483f2c2c08d5e956961
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.15e-041806249e09b3dfe344b5d50520711513d389865d73a861
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.15e-04180624eee71184ebed2694d3e60f579a44b3cf7dd2cd35
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.15e-04180624b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.15e-04180624a17dbe03597b81e7a1fe2bf2d23e59e55c615a2a
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.18e-041816240513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MYLK NTN1 PTGER3 PDZRN3

1.18e-04181624fc51468c74534b60b4e786bd512d0f1c5dc05de7
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.18e-0418162430729f0364f719c044712a51453e22dc2c1a232b
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYLK PLA1A TMEM94 KLHL23

1.18e-041816241db1eb7d330a7e5090994007ae287e11f0a74450
ToppCellfacs-Heart-LV-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYLK PLA1A TMEM94 KLHL23

1.18e-0418162406174ce9240c9261c0f51a1b0d875335d60722e5
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CENPE PLEK LY75 POLQ

1.20e-0418262421dcab170ffeef89faa9fee5008568cb6e15c694
ToppCellCOVID-19-kidney-CD-IC-B|COVID-19 / Disease (COVID-19 only), tissue and cell type

CA12 ASAP2 NTN1 PTGER3

1.20e-04182624ee6a8c356bbbdae55e4ea858337e079491f9f4aa
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.20e-041826241e2149b222a3e9f64841aed45288a6f29394e7b0
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.20e-04182624d1a1feef318062f25493355d7beee8e5fb0e4206
ToppCelldroplet-Tongue-nan-24m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA1A PIK3CG DOCK10 PLEK

1.20e-041826240f06309318c064f0ebdb12a46226b90032290137
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.20e-04182624041bc819e6cf2618bf86bce8dfe2df673f392ba3
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.20e-0418262417ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.23e-041836245f2db95d44b7de68779de098892892af540fd431
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 SLC12A3 DYNC2H1 PTGER3

1.23e-041836242f0ee40e69ad1259e56e8ee4b352736900eb8901
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AFAP1 DOCK10 NTN1 PDZRN3

1.23e-041836247eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-AT1-AT2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.23e-0418362406ac66726ec53db810ebb90ec69cfdb903da53f6
ToppCellCOVID-19-kidney-CD-IC-A|kidney / Disease (COVID-19 only), tissue and cell type

CA12 DOCK10 NTN1 PTGER3

1.23e-041836245c7597a5b2bf6a481ca2c7e68560179214150fa0
ToppCell10x5'v1-week_17-19-Hematopoietic-MK-MK|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

AFAP1 MYLK PLEK PTGER3

1.23e-041836249c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-maDC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SLC12A3 DOCK10 PLEK LY75

1.23e-04183624e01dacb08a9c36cf09c0b6764ce032a7232d4cdc
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.23e-04183624e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCellCOVID-19-APC-like|COVID-19 / group, cell type (main and fine annotations)

SLC12A3 DOCK10 PLEK LY75

1.23e-04183624b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPE HIPK1 TMEM131L POLQ

1.25e-04184624a8c6028d745aaa6ee7842259238694cb50ce0526
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CENPE HIPK1 TMEM131L POLQ

1.25e-04184624081d045f3bc98a36f342de7d50f39c9a888dd7eb
ToppCellControl-Myeloid_G-immature_Neutrophil|Control / Disease group, lineage and cell class

CENPE HIPK1 TMEM131L POLQ

1.25e-0418462445f873236f7e90fb78c8e291d3b5b92d121acec9
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CENPE HIPK1 TMEM131L POLQ

1.25e-0418462484c20730cd92b9aaa50077d7b625e37e7f9e91d2
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RRP9 KIF21A SORCS2 SLC34A2

1.25e-041846247cc5796557379c3d1db078c1aeda40659c6e401c
ToppCellPBMC-Control-Myeloid-Neutrophil-immature_Neutrophil-Neu_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CENPE HIPK1 TMEM131L POLQ

1.25e-04184624d31d4116d1d196633784863781fa45673607a421
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFAP1 CENPE DAPK1 POLQ

1.25e-0418462416aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT1-AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.28e-0418562468f428e169cfb77de970bdfdeea9b9f16f68d2ba
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

MYLK KLHL23 NTN1 PDZRN3

1.28e-04185624427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.28e-0418562403f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.28e-04185624fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CENPE ZNF165 BARD1 POLQ

1.28e-0418562430e041d6f6e310d64809e9d6d93cd30052972f3b
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.28e-04185624929b68b05b7686341329ac756d7df172cb4b810b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 ASAP2 NTN1 PTGER3

1.28e-041856243d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 DOCK10 NTN1 PTGER3

1.28e-041856249438097e94219c1db922b8507e3a29106d32a923
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.31e-04186624e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SORCS2 SLC34A2 DAPK1 NTN1

1.31e-041866242ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellmild-unassigned|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DOK6 USP28 KIF19 MACROD1

1.31e-041866245b2e1a58916f392fa1156bf9210df528775248ff
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.34e-0418762485e58a312fc325e4063a2d250666b99b8f99beb6
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CA12 CLCN5 SORCS2 PTGER3

1.34e-0418762452b5b38bef3cc06487cf42c6fb22fb33f0c7ce2b
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLA1A RRP9 KIF21A SLC34A2

1.34e-04187624201ff693e4756ee3e44762885b3a303a77eb535b
ToppCelldroplet-Heart-4Chambers-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK1 MYLK KLHL23 PTGER3

1.34e-04187624dba4924d914a7dcd4901142684ba920c2404860b
DiseaseNephritis, Tubulointerstitial

CYP2C9 SLC12A3 CLCN5

1.04e-0521603C0041349
DiseaseNephritis, Interstitial

CYP2C9 SLC12A3 CLCN5

1.57e-0524603C0027707
Diseaseplatelet measurement

DOK6 OR11L1 DOCK10 TMEM131L LY75 ASAP1

4.35e-05315606EFO_0005036
DiseaseCarcinoma, Transitional Cell

KMT2C APAF1 DAPK1

8.06e-0541603C0007138
Diseasesleep duration, high density lipoprotein cholesterol measurement

AFAP1 SLC12A3 TMEM94 MYO1H

1.10e-04121604EFO_0004612, EFO_0005271
DiseaseVasogenic Brain Edema

MYLK NTN1

1.13e-048602C0750969
DiseaseCytotoxic Brain Edema

MYLK NTN1

1.13e-048602C0750970
DiseaseCytotoxic Cerebral Edema

MYLK NTN1

1.13e-048602C0472388
DiseaseVasogenic Cerebral Edema

MYLK NTN1

1.13e-048602C0472387
DiseaseBrain Edema

MYLK NTN1

1.13e-048602C1527311
DiseaseCerebral Edema

MYLK NTN1

1.13e-048602C0006114
DiseaseLeukemia, Myelocytic, Acute

KMT2C DAPK1 FANCM FAS

4.31e-04173604C0023467
Diseaseurinary bladder cancer (is_implicated_in)

CYP2C9 DAPK1 FAS

5.06e-0476603DOID:11054 (is_implicated_in)
DiseaseVascular Diseases

MYLK SLC12A3

5.42e-0417602C0042373
DiseaseAcute Lung Injury

MYLK FAS

9.15e-0422602C0242488
DiseaseRenal glomerular disease

SLC12A3 CLCN5

1.00e-0323602C0268731
DiseaseGlomerulopathy Assessment

SLC12A3 CLCN5

1.00e-0323602C4521256
Diseaseresponse to gemcitabine

DOK6 DAPK1

1.18e-0325602GO_0036272
Diseaseneuroblastoma

CA12 ASAP2 BARD1

1.72e-03116603EFO_0000621
Diseasefasting blood glucose change measurement

KLHL23 LY6L

1.94e-0332602EFO_0010120
Diseaseasthma, response to diisocyanate

ASAP2 DYNC2H1 TMEM131L ASAP1

1.98e-03261604EFO_0006995, MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
IRLWETKKVCKNSAV

APAF1

906

O14727
AGKIKLWDLRTTKCV

DCAF4

391

Q8WV16
ARKKWKQSVRLISLC

DAPK1

301

P53355
KKSDGIRRVWQKRKC

ASAP3

311

Q8TDY4
LKFEWVKACLRRKVC

BARD1

631

Q99728
GLCRRLQKFWRVTVK

ARMH2

21

H3BNL8
LRKKRFGQWTKLLCV

AFAP1

161

Q8N556
VCKGKWKNKERILIF

BRIX1

51

Q8TDN6
KKRCFSELIRPWHKT

DIABLO

31

Q9NR28
FWSLEKKCGQKLVSR

NWD2

646

Q9ULI1
LKCIRKWRSAKEFES

MKRN4P

346

Q13434
WIRSRDIACKCPKIK

NTN1

536

O95631
WKVKIRSDGTRYITK

PDZRN3

921

Q9UPQ7
GQVFRLVEKKTRKVW

MYLK

1476

Q15746
IKITKVVLSKGWRCL

KMT2C

991

Q8NEZ4
FGQVAKCWKRSTKEI

HIPK1

201

Q86Z02
SDGIRKVWQKRKCSV

ASAP2

316

O43150
TRKEIWCSKRVLFLT

FANCM

176

Q8IYD8
TGKIKLWDLRATKCV

DCAF4L1

291

Q3SXM0
VVSIWLFRRKSIKKG

CA12

321

O43570
FRVIKVNKECVRGLW

PCNX1

1936

Q96RV3
ESKRKKSFLLCIGWL

PTGER3

81

P43115
IVTVKIGWTKCKRND

CSTL1

81

Q9H114
VGKWEVKDCRSFKAL

LY75

606

O60449
VSFKWSVRVLLSKRC

LY6L

61

H3BQJ8
GGFAVVCKDRKWTKI

KDM5B

141

Q9UGL1
RRKCGILWSTSKRKF

OR11L1

306

Q8NGX0
CVDISKKDKRVTRRW

OSBPL6

301

Q9BZF3
RKEILTGTKCIWVKA

KIF19

771

Q2TAC6
KLRKWHTTFCEKVVV

DYNC2H1

691

Q8NCM8
KESRRILCSKFKEVW

KLHL23

156

Q8NBE8
RKGYWKVEKICTASL

DOCK10

1736

Q96BY6
RCWLVFKKASSKGPR

DOK6

26

Q6PKX4
IKEWRCKKRFSISLA

POLQ

1841

O75417
IAWCRKRKTTQLGKY

CLCN5

411

P51795
DGIRKVWQRRKCSVK

ASAP1

336

Q9ULH1
CKDFVRLKKIPTWKE

MACROD1

116

Q9BQ69
KWRRFAKIQIGLKVC

GCNA

566

Q96QF7
GIVFSNGKKWKEIRR

CYP2C9

111

P11712
KRKRRVTWCLGKINK

CENPE

416

Q02224
WSKSRTCRKNKKRGV

TMEM131L

1211

A2VDJ0
AWVRDIKKAIKCIEG

PLEK

91

P08567
VGFKEFSRKCSEKWR

HMGB4

36

Q8WW32
RKRKSTSWCIKGRSF

SORCS2

676

Q96PQ0
KWSERDTKGKILCFF

SLC34A2

81

O95436
TVSLWDCDRKFRVKI

PIK3CG

351

P48736
RVWKKDRTTIIGKFC

PLA1A

406

Q53H76
FWCRTCKKELTRKDT

ZNF451

531

Q9Y4E5
LIVWVKRKEVQKTCR

FAS

186

P25445
GHLRERKKCLTWKEV

TMEM94

36

Q12767
KDCSIIKWSVESGRK

RRP9

166

O43818
KVWDIRDSAKCIRTL

KIF21A

1411

Q7Z4S6
ADKTVKLWKAGRCER

PLAA

171

Q9Y263
DKTIRIWDVRTTKCI

THOC3

121

Q96J01
GRKRRWSKCKIRVFV

SLC12A3

851

P55017
VPTKRSFECKEKLWK

TSTD2

66

Q5T7W7
SAETKRSKRKRCEVW

USP28

131

Q96RU2
FKENRCLLKTGTVKW

ZHX2

676

Q9Y6X8
ICKSAGRVKRQWEKE

ZNF165

226

P49910
ESVRIWDVKTGKCLK

WDR5

151

P61964
KWAVRIIRKFIKGFI

MYO1H

751

Q8N1T3
RTWRSVPEKKECVVK

PCSK1

456

P29120