Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

1.36e-0890185GO:0008028
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

8.76e-07207185GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

8.97e-07208185GO:0005342
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ATP1A4 SLC16A5 CLCN7 SLC16A1 SLC16A11 SLC16A13

2.62e-06477186GO:0022804
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

4.82e-06293185GO:0008514
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC16A5 CLCN7 SLC16A1 SLC16A11 SLC16A13

5.06e-06296185GO:0015291
GeneOntologyMolecularFunctionsymporter activity

SLC16A5 SLC16A1 SLC16A11 SLC16A13

8.62e-06150184GO:0015293
GeneOntologyMolecularFunctiontransmembrane transporter activity

ATP1A4 SLC16A5 CLCN7 SLC16A1 SLC16A11 SLC16A13 SLC27A4

4.42e-051180187GO:0022857
GeneOntologyMolecularFunctiontransporter activity

ATP1A4 SLC16A5 CLCN7 SLC16A1 SLC16A11 SLC16A13 SLC27A4

7.77e-051289187GO:0005215
GeneOntologyMolecularFunctionstructural molecule activity

MRPL16 CLDN25 CLDN22 CLDN24

7.30e-03891184GO:0005198
GeneOntologyBiologicalProcesscarboxylic acid transport

SLC16A5 SLC16A1 SLC16A11 SLC16A13 GABBR1 SLC27A4

6.11e-07410176GO:0046942
GeneOntologyBiologicalProcessmonocarboxylic acid transport

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

6.27e-07213175GO:0015718
GeneOntologyBiologicalProcessorganic acid transport

SLC16A5 SLC16A1 SLC16A11 SLC16A13 GABBR1 SLC27A4

6.29e-07412176GO:0015849
GeneOntologyBiologicalProcessorganic anion transport

SLC16A5 SLC16A1 SLC16A11 SLC16A13 GABBR1 SLC27A4

2.30e-06515176GO:0015711
GeneOntologyBiologicalProcesscell-cell junction assembly

CLDN25 FKRP CLDN22 CLDN24

9.09e-06167174GO:0007043
GeneOntologyBiologicalProcesspyruvate transmembrane transport

SLC16A1 SLC16A11

1.34e-057172GO:1901475
GeneOntologyBiologicalProcesspyruvate transport

SLC16A1 SLC16A11

2.29e-059172GO:0006848
GeneOntologyBiologicalProcessbicellular tight junction assembly

CLDN25 CLDN22 CLDN24

3.81e-0581173GO:0070830
GeneOntologyBiologicalProcesscell-cell junction organization

CLDN25 FKRP CLDN22 CLDN24

4.16e-05246174GO:0045216
GeneOntologyBiologicalProcesstransport across blood-brain barrier

ATP1A4 SLC16A1 SLC27A4

4.72e-0587173GO:0150104
GeneOntologyBiologicalProcesstight junction assembly

CLDN25 CLDN22 CLDN24

4.89e-0588173GO:0120192
GeneOntologyBiologicalProcessvascular transport

ATP1A4 SLC16A1 SLC27A4

4.89e-0588173GO:0010232
GeneOntologyBiologicalProcessapical junction assembly

CLDN25 CLDN22 CLDN24

5.23e-0590173GO:0043297
GeneOntologyBiologicalProcesstight junction organization

CLDN25 CLDN22 CLDN24

5.95e-0594173GO:0120193
GeneOntologyBiologicalProcesscell junction assembly

CLDN25 FKRP CLDN22 CLDN24

1.02e-03569174GO:0034329
GeneOntologyBiologicalProcessvascular process in circulatory system

ATP1A4 SLC16A1 SLC27A4

2.63e-03344173GO:0003018
GeneOntologyCellularComponentbicellular tight junction

CLDN25 CLDN22 CLDN24

1.83e-04131183GO:0005923
GeneOntologyCellularComponenttight junction

CLDN25 CLDN22 CLDN24

2.18e-04139183GO:0070160
GeneOntologyCellularComponentapical junction complex

CLDN25 CLDN22 CLDN24

3.18e-04158183GO:0043296
GeneOntologyCellularComponentapical plasma membrane

SLC16A1 CLDN25 CDHR2 CLDN24

6.87e-04487184GO:0016324
GeneOntologyCellularComponentapical part of cell

SLC16A1 CLDN25 CDHR2 CLDN24

1.42e-03592184GO:0045177
GeneOntologyCellularComponentbrush border membrane

CDHR2 SLC27A4

2.29e-0383182GO:0031526
MousePhenothin retina inner nuclear layer

CLCN7 FKRP

2.84e-044092MP:0008511
MousePhenoabnormal stratification in cerebral cortex

CLCN7 FKRP

2.98e-044192MP:0000790
MousePhenoabnormal retina inner nuclear layer thickness

CLCN7 FKRP

3.60e-044592MP:0011996
MousePhenoabnormal posture

CLCN7 GABBR1 SLC27A4

4.03e-0424393MP:0001504
MousePhenoabnormal lysosome physiology

CLCN7 NCOA7

4.09e-044892MP:0003172
MousePhenoabnormal neocortex morphology

CLCN7 FKRP

4.09e-044892MP:0008547
MousePhenoabnormal reflex

FKRP NCOA7 PAQR6 GABBR1 SLC27A4

6.18e-04129495MP:0001961
MousePhenoabnormal lysosome morphology

CLCN7 NCOA7

6.61e-046192MP:0005058
MousePhenoabnormal vacuole morphology

CLCN7 NCOA7

7.74e-046692MP:0020851
MousePhenoabnormal cerebral cortex morphology

CLCN7 FKRP NCOA7

9.68e-0432893MP:0000788
MousePhenodecreased susceptibility to diet-induced hepatic steatosis

SLC16A1 SLC16A13

1.13e-038092MP:0031268
MousePhenoabnormal sensory capabilities/reflexes/nociception

FKRP NCOA7 PAQR6 GABBR1 SLC27A4

1.18e-03148695MP:0002067
DomainMFS

SLC16A5 SLC16A1 SLC16A11 SLC16A13

7.82e-0777184IPR011701
DomainMFS_1

SLC16A5 SLC16A1 SLC16A11 SLC16A13

7.82e-0777184PF07690
DomainClaudin

CLDN25 CLDN22 CLDN24

2.43e-0628183IPR006187
DomainMFS

SLC16A5 SLC16A1 SLC16A11 SLC16A13

3.04e-06108184PS50850
DomainMFS_dom

SLC16A5 SLC16A1 SLC16A11 SLC16A13

7.17e-06134184IPR020846
DomainPMP22_Claudin

CLDN25 CLDN22 CLDN24

7.26e-0640183PF00822
DomainMCT

SLC16A5 SLC16A1

8.76e-065182IPR004743
DomainPMP22/EMP/MP20/Claudin

CLDN25 CLDN22 CLDN24

1.04e-0545183IPR004031
DomainClaudin_CS

CLDN22 CLDN24

2.00e-0422182IPR017974
DomainCLAUDIN

CLDN22 CLDN24

2.00e-0422182PS01346
PathwayKEGG_MEDICUS_REFERENCE_TIGHT_JUNCTION_ACTIN_SIGNALING_PATHWAY

CLDN25 CLDN22 CLDN24

4.68e-0637133M47769
Pubmed

The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.

SLC16A5 SLC16A1 SLC16A11 SLC16A13

5.01e-111418412739169
Pubmed

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.

SLC16A1 SLC16A11 SLC16A13

2.33e-09618324390345
Pubmed

CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

CLDN25 CLDN22 CLDN24

2.55e-081218312736707
Pubmed

Structure and function of claudins.

CLDN25 CLDN22 CLDN24

2.05e-072318318036336
Pubmed

The claudins.

CLDN25 CLDN22 CLDN24

2.05e-072318319706201
Pubmed

Tight junction-based epithelial microenvironment and cell proliferation.

CLDN22 CLDN24

1.52e-06418219029935
Pubmed

Predicted expansion of the claudin multigene family.

CLDN25 CLDN24

3.79e-06618221276448
Pubmed

Fatty Acid Binding Protein 3 Is Involved in n-3 and n-6 PUFA transport in mouse trophoblasts.

SLC16A1 SLC27A4

1.97e-051318225122651
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ATP1A4 SLC16A1 SLC27A4

2.11e-0510518330280653
Pubmed

Biology of claudins.

CLDN22 CLDN24

4.30e-051918218480174
Pubmed

Multifunctional strands in tight junctions.

CLDN22 CLDN24

5.28e-052118211283726
Pubmed

Claudin-based barrier in simple and stratified cellular sheets.

CLDN22 CLDN24

5.28e-052118212231346
Pubmed

Tight junctions of the blood-brain barrier.

CLDN22 CLDN24

5.28e-052118210690502
Pubmed

The roles of claudin superfamily proteins in paracellular transport.

CLDN22 CLDN24

5.28e-052118211247307
Pubmed

Tight junction proteins.

CLDN22 CLDN24

5.28e-052118212475568
Pubmed

Lipid signatures reflect the function of the murine primary placentation†.

SLC16A1 SLC27A4

5.81e-052218234850819
Pubmed

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.

CLDN22 CLDN24

8.16e-052618222275141
Pubmed

Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos.

SLC16A11 SLC16A13

2.15e-044218238529784
Pubmed

Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.

CLDN22 CLDN24

2.26e-044318234737342
Pubmed

Establishment and Dysfunction of the Blood-Brain Barrier.

SLC16A1 SLC27A4

3.30e-045218226590417
Pubmed

Mass spectrometry analyses of normal and polyglutamine expanded ataxin-3 reveal novel interaction partners involved in mitochondrial function.

SLC16A1 SLC27A4

3.70e-045518229111377
Pubmed

Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse.

CLDN22 CLDN24

5.16e-046518233795231
Cytoband4q35.1

CLDN22 CLDN24

9.07e-05361824q35.1
CytobandEnsembl 112 genes in cytogenetic band chr4q35

CLDN22 CLDN24

9.59e-04117182chr4q35
Cytoband17p13.1

SLC16A11 SLC16A13

9.76e-0411818217p13.1
CytobandEnsembl 112 genes in cytogenetic band chr17p13

SLC16A11 SLC16A13

8.00e-03346182chr17p13
GeneFamilyClaudins

CLDN25 CLDN22 CLDN24

8.10e-0723153488
GeneFamilySolute carriers

SLC16A5 SLC16A1 SLC16A11 SLC16A13 SLC27A4

1.22e-05395155752
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 CDHR2 NCOA7 SLC27A4

6.19e-0717318499532bb768ee35fed939a377acb5215d3f8904bd
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 CDHR2 NCOA7 SLC27A4

6.19e-07173184e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 CDHR2 NCOA7 SLC27A4

6.63e-071761847622f5a8e7320cc7b593141854107ecaf4adff7f
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 NCOA7 SLC27A4

3.86e-0516618322b31acbbef1936ce19b393cf880c63ea2fa0f1b
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR2 NCOA7 SLC27A4

4.22e-051711835d0d6c1ff610a703ae0b834a12823c5ff9012932
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLDN22 SLC16A13 PAQR6

4.45e-05174183c58328c2f262506a4518f49f148e29874faf9171
ComputationalGenes in the cancer module 71.

SLC16A5 SLC16A1

1.11e-042282MODULE_71
DrugSodium Oxybate

SLC16A1 GABBR1

5.24e-065172ctd:D012978
DrugChloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A

SLC16A5 CLCN7 CDHR2 FKRP

1.18e-051971743350_UP
Drugcalcium carbonate

SLC16A5 SLC16A1 SLC16A11 SLC16A13

1.33e-05203174CID000010112
DrugPyruvic acid

SLC16A5 SLC16A1

4.75e-0514172DB00119
Diseasegout

ATP1A4 CLDN24

4.95e-03196162EFO_0004274
Diseaseaspartate aminotransferase measurement

FKRP GABBR1 CLDN24

1.19e-02904163EFO_0004736

Protein segments in the cluster

PeptideGeneStartEntry
LFLGWFAGLSLLLGG

CLDN24

166

A6NM45
LYLGWAAGIFLALGG

CLDN25

166

C9JDP6
IFGWRGSFLILGGLL

SLC16A1

171

P53985
LYLGLGLLAGFGWAL

SLC16A11

131

Q8NCK7
RLWLLGLGFSLGYGS

GABBR1

666

Q9UBS5
GAAWGRLFGISLSYL

CLCN7

521

P51798
SWLNRGALGLLYTAG

OR14K1

146

Q8NGZ2
YFLWRLLALAGGPGF

PAQR6

61

Q6TCH4
LFLGWFAGLSLLLGG

CLDN22

166

Q8N7P3
GLVLGAGWAEGYLRL

CDHR2

746

Q9BYE9
AGVRYWLEGGSLLGA

FKRP

336

Q9H9S5
GTLYLLFGAWAGVLG

MT-CO1

16

P00395
NFAILALGGGYLHWG

MRPL16

86

Q9NX20
GGGGRFGLWLDADLY

NCOA7

896

Q8NI08
GVTFFALSLLLGYGW

ATP1A4

311

Q13733
FFSILGTGLLWLPGG

SFT2D1

46

Q8WV19
LYLSIGLLSGSGWAL

SLC16A13

106

Q7RTY0
LGWRGTFLVFGGIFL

SLC16A5

166

O15375
GFSLLFLYLGSGGWR

SLC27A4

26

Q6P1M0