Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

PRAMEF9 ANKRD9 PRAMEF15 TUT1 PRAMEF4 KLHL22 RPTOR PRAMEF27 PRAMEF11

3.65e-09951149GO:0140767
GeneOntologyMolecularFunctionGTPase activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B PLEKHG6 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

6.81e-0827911412GO:0005096
GeneOntologyMolecularFunctionenzyme activator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D CXCL1 TBC1D3C TBC1D3B CCND3 PSME4 PLEKHG6 RPTOR TBC1D3I FAM20A TBC1D3G TBC1D3K TBC1D3F

1.88e-0765611417GO:0008047
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

PRAMEF9 ANKRD9 PRAMEF15 PRAMEF4 KLHL22 PRAMEF27 PRAMEF11

4.38e-07821147GO:1990756
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B PLEKHG4B PLEKHG6 HERC1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.19e-0650711414GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B PLEKHG4B PLEKHG6 HERC1 TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.19e-0650711414GO:0030695
GeneOntologyMolecularFunctionenzyme regulator activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L CRIM1 TBC1D3D HSPBP1 ADGRV1 CXCL1 TBC1D3C TBC1D3B CCND3 PLEKHG4B PSME4 PLEKHG6 RPTOR SERPINA10 HERC1 TBC1D3I FAM20A TBC1D3G TBC1D3K TBC1D3F

4.38e-06141811423GO:0030234
GeneOntologyMolecularFunctionmolecular adaptor activity

BCL9L ZCCHC12 PRAMEF9 ANKRD9 PRAMEF15 SARM1 ATG2B PEX6 TUT1 PRAMEF4 ATG2A EMILIN1 KLHL22 AP4E1 DEDD2 GSDMD RPTOR NFKB1 SLC35D3 PRAMEF27 BAG6 PRAMEF11

7.32e-06135611422GO:0060090
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

BCL9L ZCCHC12 PRAMEF9 ANKRD9 PRAMEF15 SARM1 ATG2B PEX6 TUT1 PRAMEF4 ATG2A KLHL22 AP4E1 DEDD2 GSDMD RPTOR NFKB1 SLC35D3 PRAMEF27 PRAMEF11

8.41e-06116011420GO:0030674
GeneOntologyMolecularFunctionmolecular function activator activity

SEMA3F TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D CXCL1 TBC1D3C TBC1D3B CCND3 SEMA3D PSME4 PLEKHG6 RPTOR TBC1D3I FAM20A TBC1D3G TBC1D3K TBC1D3F

6.77e-05123311419GO:0140677
GeneOntologyMolecularFunctionnuclear retinoic acid receptor binding

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

2.75e-04551144GO:0042974
GeneOntologyMolecularFunctiontranslation initiation factor binding

ANGEL1 EIF3CL EIF3C

1.43e-03391143GO:0031369
GeneOntologyBiologicalProcessactivation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.63e-1110911111GO:0090630
GeneOntologyBiologicalProcesspositive regulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

8.47e-0824411111GO:0043547
GeneOntologyBiologicalProcessregulation of GTPase activity

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.96e-0633511111GO:0043087
GeneOntologyBiologicalProcesspositive regulation of hydrolase activity

TBC1D3E TBC1D3 SLC11A2 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.59e-0549911112GO:0051345
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

5.40e-06471135GO:0031462
GeneOntologyCellularComponentphagophore

ATG2B ATG2A

8.66e-0531132GO:0061908
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

PRAMEF9 ANKRD9 PRAMEF15 PRAMEF4 KLHL22 PRAMEF27 PRAMEF11

1.56e-042121137GO:0031461
MousePhenodilated renal tubule

NPHS1 CRIM1 LGR4 CRB3 FAM20A BAG6

2.07e-05101786MP:0002705
DomainTBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.86e-134910810SM00164
DomainRabGAP-TBC

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

4.33e-135310810PF00566
DomainTBC_RABGAP

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

6.43e-135510810PS50086
DomainRab-GTPase-TBC_dom

TBC1D3E TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

6.43e-135510810IPR000195
DomainVPS13_N

ATG2B ATG2A VPS13D

1.03e-0581083IPR026854
DomainChorein_N

ATG2B ATG2A VPS13D

1.03e-0581083PF12624
DomainARM-type_fold

SARM1 HSPBP1 HUWE1 AP4E1 PSME4 INF2 RPTOR ARMC5 DIAPH2 HTT

2.73e-0533910810IPR016024
DomainATG2

ATG2B ATG2A

3.31e-0521082IPR026849
DomainATG2_CAD

ATG2B ATG2A

3.31e-0521082PF13329
DomainEIF3C_N_dom

EIF3CL EIF3C

3.31e-0521082IPR008905
DomaineIF-3c_N

EIF3CL EIF3C

3.31e-0521082PF05470
DomainEIF3C

EIF3CL EIF3C

3.31e-0521082IPR027516
DomainATG2_CAD_motif

ATG2B ATG2A

3.31e-0521082IPR026885
DomainPRAME_family

PRAMEF15 PRAMEF4 PRAMEF27

1.70e-04191083IPR026271
DomainARM-like

SARM1 HSPBP1 HUWE1 AP4E1 PSME4 RPTOR ARMC5 HTT

1.74e-042701088IPR011989
Domain-

SARM1 HSPBP1 AP4E1 PSME4 RPTOR ARMC5 HTT

3.08e-0422210871.25.10.10
DomainATG_C

ATG2B ATG2A

3.28e-0451082PF09333
DomainSec6

EXOC3L4 EXOC3L1

3.28e-0451082PF06046
DomainEXOC3/Sec6

EXOC3L4 EXOC3L1

3.28e-0451082IPR010326
DomainAutophagy-rel_C

ATG2B ATG2A

3.28e-0451082IPR015412
DomainDrf_GBD

INF2 DIAPH2

1.16e-0391082PF06371
DomainFH3_dom

INF2 DIAPH2

1.16e-0391082IPR010472
DomainGTPase-bd

INF2 DIAPH2

1.16e-0391082IPR010473
DomainDrf_FH3

INF2 DIAPH2

1.16e-0391082PF06367
DomainDrf_FH3

INF2 DIAPH2

1.16e-0391082SM01139
DomainDrf_GBD

INF2 DIAPH2

1.16e-0391082SM01140
DomainGBD/FH3_dom

INF2 DIAPH2

1.76e-03111082IPR014768
DomainGBD_FH3

INF2 DIAPH2

1.76e-03111082PS51232
Domain-

LRRC75B PRAMEF15 LGR4 PRAMEF4 CEP78 LRRC61 PRAMEF27

2.63e-0332110873.80.10.10
DomainL_dom-like

LRRC75B PRAMEF15 LGR4 PRAMEF4 CEP78 LRRC61 PRAMEF27

2.97e-033281087IPR032675
DomainFH2

INF2 DIAPH2

3.31e-03151082PS51444
DomainFH2_Formin

INF2 DIAPH2

3.31e-03151082IPR015425
DomainFH2

INF2 DIAPH2

3.31e-03151082PF02181
DomainFH2

INF2 DIAPH2

3.31e-03151082SM00498
DomainPINT

EIF3CL EIF3C

3.77e-03161082SM00088
DomainPCI_dom

EIF3CL EIF3C

4.26e-03171082IPR000717
DomainPCI

EIF3CL EIF3C

4.26e-03171082PF01399
DomainSemaphorin

SEMA3F SEMA3D

5.88e-03201082IPR027231
DomainClaudin_CS

CLDN22 CLDN24

7.10e-03221082IPR017974
DomainCLAUDIN

CLDN22 CLDN24

7.10e-03221082PS01346
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K

2.18e-0999749M46448
Pubmed

TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

3.16e-28111151116863688
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DOC2A SEMA3F FLNC ITPRIPL2 ANKRD9 PIEZO1 PEX6 ATG2A HUWE1 KIAA2013 CCND3 JAK3 PSME4 INF2 PCNX4 RPTOR DIAPH2 HERC1 HTT

4.03e-0911051151935748872
Pubmed

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

TBC1D3E TBC1D3 TBC1D3H TBC1D3D TBC1D3B TBC1D3G TBC1D3F

5.38e-0974115716625196
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

ANGEL1 ATG2B PEX6 ATG2A VPS13D INF2 RPTOR DHRS7 NECTIN2 DIAPH2 EIF3C BAG6

1.20e-075041151234432599
Pubmed

PRC17, a novel oncogene encoding a Rab GTPase-activating protein, is amplified in prostate cancer.

TBC1D3 TBC1D3D TBC1D3F

1.41e-074115312359748
Pubmed

Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes.

TBC1D3 TBC1D3D TBC1D3F

1.41e-07411538406013
Pubmed

The Tre2 (USP6) oncogene is a hominoid-specific gene.

TBC1D3 TBC1D3D TBC1D3C

3.50e-075115312604796
Pubmed

Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes.

TBC1D3 TBC1D3D TBC1D3F

3.50e-07511538471161
Pubmed

Preferentially Expressed Antigen in Melanoma (PRAME) and the PRAME Family of Leucine-Rich Repeat Proteins.

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

5.28e-0720115426694250
Pubmed

Sertoli cell-only phenotype and scRNA-seq define PRAMEF12 as a factor essential for spermatogenesis in mice.

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

7.92e-0722115431729367
Pubmed

MAGE-B4, a binding partner of PRAMEF12, is dispensable for spermatogenesis and male fertility in mice.

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

1.36e-0625115437451217
Pubmed

Differences in gene expression between mouse and human for dynamically regulated genes in early embryo.

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

2.18e-0628115425089626
Pubmed

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

EIF3CL RPTOR EIF3C

4.16e-0610115316286006
Pubmed

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse.

PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

5.49e-0635115419389355
Pubmed

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

HSPBP1 HUWE1 CEP78 BAG6

6.16e-0636115435379950
Pubmed

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.

ATG2B ATG2A

1.08e-052115228800131
Pubmed

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

ATG2B ATG2A

1.08e-052115222219374
Pubmed

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

NFKBID NFKB1

1.08e-052115229222168
Pubmed

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

EIF3CL EIF3C

1.08e-052115236157221
Pubmed

Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.

HSPBP1 HTT

1.08e-052115228847953
Pubmed

A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease.

NFKB1 HTT

1.08e-052115225938884
Pubmed

16p11.2 CNV gene Doc2α functions in neurodevelopment and social behaviors through interaction with Secretagogin.

DOC2A SCGN

1.08e-052115237354460
Pubmed

The Proteasome Activators Blm10/PA200 Enhance the Proteasomal Degradation of N-Terminal Huntingtin.

PSME4 HTT

1.08e-052115233233776
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

FLNC HSPBP1 EIF3CL MAP3K15 EIF3C HERC1 BAG6

1.24e-05231115736597993
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

LARGE2 HK3 PRAMEF15 ANGEL1 LGR4 PATL1 PRAMEF4 HUWE1 PSME4 INF2 EXOC3L4 EXOC3L1 HERC1 PRAMEF11

1.44e-0510841151411544199
Pubmed

Differential expression of PRAMEL1, a cancer/testis antigen, during spermatogenesis in the mouse.

PRAMEF15 PRAMEF4 PRAMEF11

2.32e-0517115323565261
Pubmed

Mouse Pramel1 regulates spermatogonial development by inhibiting retinoic acid signaling during spermatogenesis.

PRAMEF15 PRAMEF4 PRAMEF11

2.32e-0517115337781892
Pubmed

The promoter of the oocyte-specific gene, Oog1, functions in both male and female meiotic germ cells in transgenic mice.

PRAMEF15 PRAMEF4 PRAMEF11

2.77e-0518115323894331
Pubmed

Pramel15 facilitates zygotic nuclear DNMT1 degradation and DNA demethylation.

PRAMEF15 PRAMEF4 PRAMEF11

2.77e-0518115339181896
Pubmed

Oogenesin is a novel mouse protein expressed in oocytes and early cleavage-stage embryos.

PRAMEF15 PRAMEF4 PRAMEF11

2.77e-0518115312890732
Pubmed

Oocyte-specific gene Oog1 suppresses the expression of spermatogenesis-specific genes in oocytes.

PRAMEF15 PRAMEF4 PRAMEF11

2.77e-0518115329731491
Pubmed

Identification of a new expanding family of genes characterized by atypical LRR domains. Localization of a cluster preferentially expressed in oocyte.

PRAMEF15 PRAMEF4 PRAMEF11

2.77e-0518115314675769
Pubmed

Aggregate-centered redistribution of proteins by mutant huntingtin.

HSPBP1 HTT

3.24e-053115217208201
Pubmed

LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts.

CXCL1 NFKB1

3.24e-053115219430878
Pubmed

Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex.

HUWE1 BAG6

3.24e-053115235569519
Pubmed

Diversity of human copy number variation and multicopy genes.

TBC1D3E TBC1D3G

3.24e-053115221030649
Pubmed

A conserved ATG2-GABARAP family interaction is critical for phagophore formation.

ATG2B ATG2A

3.24e-053115232009292
Pubmed

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1.

CXCL1 NFKB1

3.24e-053115234049975
Pubmed

Nephrin deficiency activates NF-kappaB and promotes glomerular injury.

NPHS1 NFKB1

3.24e-053115219497968
Pubmed

Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling.

INF2 DIAPH2

3.24e-053115223620398
Pubmed

Low expression of IL-6 and TNF-α correlates with the presence of the nuclear regulators of NF-κB, IκBNS and BCL-3, in the uterus of mice.

NFKBID NFKB1

3.24e-053115226442662
Pubmed

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

PRAMEF15 PRAMEF4 PRAMEF11

3.28e-0519115328604677
Pubmed

Oog1, an oocyte-specific protein, interacts with Ras and Ras-signaling proteins during early embryogenesis.

PRAMEF15 PRAMEF4 PRAMEF11

3.85e-0520115316580637
Pubmed

Pramel7 mediates LIF/STAT3-dependent self-renewal in embryonic stem cells.

PRAMEF15 PRAMEF4 PRAMEF11

3.85e-0520115321425410
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

ITPRIPL2 CRIM1 SARM1 LGR4 PEX6 GALNT12 PCDHA4 TUT1 HUWE1 DHRS7 NECTIN2 HERC1 BAG6

5.09e-0510611151333845483
Pubmed

Oogenesis specific genes (Nobox, Oct4, Bmp15, Gdf9, Oogenesin1 and Oogenesin2) are differentially expressed during natural and gonadotropin-induced mouse follicular development.

PRAMEF15 PRAMEF4 PRAMEF11

5.94e-0523115319480014
Pubmed

Tight junction-based epithelial microenvironment and cell proliferation.

CLDN22 CLDN24

6.48e-054115219029935
Pubmed

Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses.

SLC2A5 RPTOR

6.48e-054115237863051
Pubmed

Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.

EIF3CL EIF3C

6.48e-054115210504338
Pubmed

Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2).

INF2 DIAPH2

6.48e-054115221278336
Pubmed

Transcription of nephrin-Neph3 gene pair is synergistically activated by WT1 and NF-κB and silenced by DNA methylation.

NPHS1 NFKB1

6.48e-054115221980157
Pubmed

BAT3 negatively regulates lipopolysaccharide-induced NF-κB signaling through TRAF6.

NFKB1 BAG6

6.48e-054115227501752
Pubmed

Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

CXCL1 NFKB1

6.48e-054115215845480
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

SARM1 GALNT12 HSPBP1 HUWE1 KIAA2013 CEP78 INF2 RPTOR DHRS7 NECTIN2 SLC47A1 BAG6

6.97e-059421151231073040
Pubmed

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

PRAMEF15 PRAMEF4 PRAMEF11

7.68e-0525115312620990
Pubmed

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.

ATG2B HUWE1 RPTOR

7.68e-0525115330340022
Pubmed

Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

PRAMEF15 PRAMEF4 PRAMEF11

8.66e-0526115318500982
Pubmed

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets.

CFAP251 HUWE1 TBC1D3B LIG1 CEP78 ERICH6

1.07e-04225115625277244
Pubmed

Involvement of the neuropeptide substance P in lung inflammation induced by hepatic ischemia/reperfusion.

CXCL1 NFKB1

1.08e-045115215167973
Pubmed

The Ron receptor tyrosine kinase positively regulates angiogenic chemokine production in prostate cancer cells.

CXCL1 NFKB1

1.08e-045115219838218
Pubmed

Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.

SEMA3F SEMA3D

1.08e-045115218818766
Pubmed

A key role for early growth response-1 and nuclear factor-kappaB in mediating and maintaining GRO/CXCR2 proliferative signaling in esophageal cancer.

CXCL1 NFKB1

1.08e-045115219435811
Pubmed

Selective regulation of a defined subset of inflammatory and immunoregulatory genes by an NF-κB p50-IκBζ pathway.

NFKBID NFKB1

1.08e-045115238918046
Pubmed

Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.

ATG2B ATG2A

1.08e-045115222710871
Pubmed

c-REL and IκBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.

NFKBID NFKB1

1.08e-045115228652399
Pubmed

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

HUWE1 BAG6 HTT

1.09e-0428115325752541
Pubmed

Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice.

PRAMEF15 PRAMEF4 PRAMEF11

1.34e-0430115338786026
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

FLNC VPS13D DIAPH2 EIF3C ANKRD34C BAG6

1.36e-04235115630258100
Pubmed

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.

ATG2B ATG2A RPTOR HERC1 HTT

1.46e-04150115532423001
Pubmed

Chromosomal domains and escape from X inactivation: comparative X inactivation analysis in mouse and human.

KDM5C HUWE1

1.61e-046115211003698
Pubmed

Peptide-induced negative selection of thymocytes activates transcription of an NF-kappa B inhibitor.

NFKBID NFKB1

1.61e-046115211931770
Pubmed

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.

PRAMEF15 PRAMEF4 PRAMEF11

1.63e-0432115337889087
Pubmed

NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.

NPDC1 CCND3

2.25e-047115211042687
Pubmed

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.

CXCL1 NFKB1

2.25e-047115218542050
Pubmed

JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.

JAK3 NFKB1

3.00e-048115219414010
Pubmed

Genetic targeting of Card19 is linked to disrupted NINJ1 expression, impaired cell lysis, and increased susceptibility to Yersinia infection.

SARM1 GSDMD

3.00e-048115234648590
Pubmed

The m subunit of murine translation initiation factor eIF3 maintains the integrity of the eIF3 complex and is required for embryonic development, homeostasis, and organ size control.

EIF3CL EIF3C

3.84e-049115224003236
Pubmed

The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.

EIF3CL EIF3C

3.84e-049115221292980
Pubmed

EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.

CXCL1 JAK3 NFKB1

4.23e-0444115335493520
Pubmed

Conservation and diversity of eukaryotic translation initiation factor eIF3.

EIF3CL EIF3C

4.79e-041011528995409
Pubmed

Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.

SEMA3F SEMA3D

4.79e-0410115215550623
Pubmed

Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion.

DOC2A SCGN

4.79e-0410115221528130
Pubmed

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.

PRAMEF15 PRAMEF4 PRAMEF11

4.82e-0446115317287250
Pubmed

The DNA sequence and analysis of human chromosome 14.

ANKRD9 ANGEL1 ATG2B DHRS7

5.17e-04111115412508121
Pubmed

Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.

FLNC BAG6

5.85e-0411115236579465
Pubmed

Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways.

CXCL1 NFKB1

5.85e-0411115217466952
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

FLNC PRAMEF15 HSPBP1 PRAMEF4 VPS13D PSME4 EXOC3L4 PRAMEF11

5.90e-04564115821565611
Pubmed

DUX is a non-essential synchronizer of zygotic genome activation.

PRAMEF15 PRAMEF4 PRAMEF11

6.16e-0450115331806660
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

FLNC KDM5C HUWE1 KIAA2013 CEP78 BAG6

6.27e-04313115638270169
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

SEMA3F LARGE2 ITPRIPL2 CRIM1 PIEZO1 PON2 LGR4 HSPBP1 KIAA2013 NECTIN2 TXNDC16 HTT

6.39e-0412011151235696571
Pubmed

Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.

SEMA3F SEMA3D

7.00e-0412115219812329
Pubmed

Neuropilins guide preganglionic sympathetic axons and chromaffin cell precursors to establish the adrenal medulla.

SEMA3F OLIG1

7.00e-0412115230237243
Pubmed

Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons.

SEMA3F SEMA3D

7.00e-0412115223991118
Pubmed

Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3.

EIF3CL EIF3C

7.00e-0412115214519125
Pubmed

Reconstitution reveals the functional core of mammalian eIF3.

EIF3CL EIF3C

7.00e-0412115217581632
Pubmed

CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.

CLDN22 CLDN24

7.00e-0412115212736707
Pubmed

PAQR9 Modulates BAG6-mediated protein quality control of mislocalized membrane proteins.

HUWE1 BAG6

7.00e-0412115231904842
Pubmed

RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins.

HUWE1 BAG6

8.26e-0413115232645369
Pubmed

ZAR1 and ZAR2 are required for oocyte meiotic maturation by regulating the maternal transcriptome and mRNA translational activation.

PRAMEF15 PRAMEF4 PRAMEF11

9.52e-0458115331598710
Pubmed

HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.

JAK3 NFKB1

9.61e-0414115224244375
CytobandEnsembl 112 genes in cytogenetic band chr17q12

TBC1D3E TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3I TBC1D3G TBC1D3K TBC1D3F

1.54e-1314911511chr17q12
Cytoband17q12

TBC1D3 TBC1D3H TBC1D3C TBC1D3B TBC1D3F

5.36e-0699115517q12
Cytoband1p36.21

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF11

1.99e-056311541p36.21
CytobandEnsembl 112 genes in cytogenetic band chr1p36

PRAMEF9 PRAMEF15 PRAMEF4 SLC2A5 KIAA2013 VPS13D PRAMEF27 PRAMEF11

3.31e-046811158chr1p36
Cytoband16p11.2

DOC2A EIF3CL ARMC5 EIF3C

1.40e-03191115416p11.2
Cytoband17q24.2

C17orf58 FAM20A

2.58e-0330115217q24.2
GeneFamilyPRAME family

PRAMEF9 PRAMEF15 PRAMEF4 PRAMEF27 PRAMEF11

2.61e-0824685686
CoexpressionAtlasMesoderm Day 5-reprogram_OSKM-L_vs_Mesoderm Day 5-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

LARGE2 FLNC TBC1D3 TBC1D3H TBC1D3L CRIM1 TBC1D3D NFKBID PCDHA4 CCDC57 TBC1D3C TBC1D3B FAM20A TBC1D3G PHF21B TBC1D3K TBC1D3F

5.76e-1428110717PCBC_ratio_MESO-5_from-OSKM-L_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5-method_mRNA_vs_Mesoderm Day 5-method_NA-Confounder_removed-fold2.0_adjp0.05

LARGE2 FLNC TBC1D3 TBC1D3H TBC1D3L CRIM1 TBC1D3D NFKBID PCDHA4 CCDC57 TBC1D3C TBC1D3B FAM20A TBC1D3G PHF21B TBC1D3K TBC1D3F

5.76e-1428110717PCBC_ratio_MESO-5_from-mRNA_vs_MESO-5_from-ESC_cfr-2X-p05
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 30-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D GALNT12 TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F

2.81e-119010710PCBC_ratio_MESO-15_vs_MESO-30_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-method_mRNA_vs_Endoderm Differentiated Cells-method_NA-Confounder_removed-fold2.0_adjp0.05

LRRC75B TBC1D3 TBC1D3H TBC1D3L TBC1D3D ANKRD9 TBC1D3C TBC1D3B FAM20A TBC1D3G TBC1D3K TBC1D3F

8.18e-1021310712PCBC_ratio_DE_from-mRNA_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasEndoderm Differentiated Cells-reprogram_OSKM-L_vs_Endoderm Differentiated Cells-reprogram_NA-Confounder_removed-fold2.0_adjp0.05

LRRC75B TBC1D3 TBC1D3H TBC1D3L TBC1D3D ANKRD9 TBC1D3C TBC1D3B FAM20A TBC1D3G TBC1D3K TBC1D3F

8.18e-1021310712PCBC_ratio_DE_from-OSKM-L_vs_DE_from-ESC_cfr-2X-p05
CoexpressionAtlasDE cord blood_vs_DE blastocyst-Confounder_removed-fold2.0_adjp0.05

LRRC75B TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B FAM20A TBC1D3G TBC1D3K TBC1D3F

3.97e-0824210711PCBC_ratio_DE cord blood_vs_DE blastocyst_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Endoderm Differentiated Cells-Confounder_removed-fold2.0_adjp0.05

LRRC75B TBC1D3 TBC1D3H TBC1D3L TBC1D3D TBC1D3C TBC1D3B TBC1D3G TBC1D3K TBC1D3F

5.07e-0632010710PCBC_ratio_MESO-5_vs_DE_cfr-2X-p05
CoexpressionAtlasMesoderm Day 5_vs_Pluripotent Stem Cells-Confounder_removed-fold2.0_adjp0.05

SEMA3F FLNC LRRC75B TBC1D3 TBC1D3H TBC1D3L TBC1D3D PIEZO1 TBC1D3C TBC1D3B KLHL22 INF2 PCNX4 CRB3 FAM20A TBC1D3G TBC1D3K TBC1D3F

1.73e-05115310718PCBC_ratio_MESO-5_vs_SC_cfr-2X-p05
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#5_top-relative-expression-ranked_500

LGR4 HUWE1 SEMA3D

1.55e-04211073gudmap_developingKidney_e15.5_Peripheral blastema_500_k5
CoexpressionAtlasMesoderm Day 15_vs_Mesoderm Day 5-Confounder_removed-fold2.0_adjp0.05

TBC1D3 TBC1D3H TBC1D3L TBC1D3D OGFR SPTBN2 SARM1 PON2 PEX6 TBC1D3C TBC1D3B PLEKHG6 TBC1D3G TBC1D3K TBC1D3F

2.45e-04104910715PCBC_ratio_MESO-15_vs_MESO-5_cfr-2X-p05
Diseaseinterleukin 17 receptor B measurement

CACNA1D SARM1

1.59e-046972EFO_0008176
DiseaseCXCL1 measurement

SARM1 CXCL1

3.79e-049972EFO_0010777
Disease2-ketocaprylate measurement

PCNX4 DHRS7

4.73e-0410972EFO_0800110
Diseasepeptidoglycan recognition protein 1 measurement

CCDC61 NECTIN2

4.73e-0410972EFO_0020624
Diseaseinterleukin-22 receptor subunit alpha-2 measurement

SARM1 NFKB1

5.77e-0411972EFO_0020500
DiseaseFamilial idiopathic steroid-resistant nephrotic syndrome

NPHS1 INF2

8.15e-0413972cv:C4273714
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Positive

ANKRD9 CXCL1 MEX3C FAM20A

9.34e-04131974C4704862
DiseasePolyarthritis, Juvenile, Rheumatoid Factor Negative

ANKRD9 CXCL1 MEX3C FAM20A

9.34e-04131974C4552091
DiseaseJuvenile arthritis

ANKRD9 CXCL1 MEX3C FAM20A

9.34e-04131974C3495559
DiseaseJuvenile psoriatic arthritis

ANKRD9 CXCL1 MEX3C FAM20A

9.34e-04131974C3714758
DiseaseJuvenile-Onset Still Disease

ANKRD9 CXCL1 MEX3C FAM20A

1.04e-03135974C0087031
Diseaseneurodegenerative disease (implicated_via_orthology)

SARM1 PON2 NFKB1 HTT

1.36e-03145974DOID:1289 (implicated_via_orthology)
DiseaseCCL4 measurement

TBC1D3 TBC1D3F

1.96e-0320972EFO_0004751
Diseasecortisol measurement

TMPRSS9 SERPINA10

1.96e-0320972EFO_0005843
DiseaseRenal glomerular disease

NPHS1 INF2

2.59e-0323972C0268731
DiseaseGlomerulopathy Assessment

NPHS1 INF2

2.59e-0323972C4521256
Diseasethalamus volume

SEMA3F ADGRV1 NFKB1

2.80e-0385973EFO_0006935

Protein segments in the cluster

PeptideGeneStartEntry
RELLNLRDPALLGLE

EXOC3L1

651

Q86VI1
AQLLAELGGLVRRDL

EXOC3L4

276

Q17RC7
GDDLLLLASLIKIRR

ERICH6

591

Q7L0X2
AEALRGLVRGLELEL

CCDC61

216

Q9Y6R9
QRDLKRRLLILGGIL

CLDN24

111

A6NM45
LLGDQRVLQSLLRLE

CCND3

21

P30281
LGRLRLTRLLLEGGA

ANKRD34C

21

P0C6C1
LLERRGSGTLLLDRI

ANKRD34C

441

P0C6C1
RLINLVGESLRLLGN

BAG6

321

P46379
LRVALLLLLLVAAGR

CXCL1

16

P09341
LELLDRELCQLLLEG

GSDMD

301

P57764
DGEIRLLVIRAQGLL

ADGRV1

1736

Q8WXG9
WRRLLLEQGGLRLLL

ARMC5

671

Q96C12
LEQGGLRLLLAALTR

ARMC5

676

Q96C12
NLLLAEGTLRLLTRL

AP5S1

131

Q9NUS5
ELNGLILRERDLTIL

CEP78

126

Q5JTW2
SNLRLLGQLLRVLAR

DEDD2

81

Q8WXF8
GLQRILGDERSLLLL

DIAPH2

246

O60879
LLLLVQLLRFLRADG

DHRS7

16

Q9Y394
QLLRFLRADGDLTLL

DHRS7

21

Q9Y394
ELGALDRLAALLRLA

ATG2A

596

Q2TAZ0
GRLIGRLELSLTLKQ

ATG2B

286

Q96BY7
QLLRILGLLGKDDQR

AP4E1

276

Q9UPM8
NEPRLLSLGTDRLLI

CFAP251

756

Q8TBY9
ALCRLLELLEEGQRL

JAK3

1046

P52333
TGVILLRLDRLRQAG

LARGE2

256

Q8N3Y3
TLRASLLLLGLLTEG

NPHS1

6

O60500
LSLLLILLSRGEDLQ

PATL1

686

Q86TB9
LLEDGLLLSQSRQRI

KIAA0100

336

Q14667
VLLSLRLLENRALGD

FANCF

91

Q9NPI8
ESILLLKLRGLGLAD

LRRC61

31

Q9BV99
TLVQLLLELPRGDLR

NFKBID

221

Q8NI38
AGIRLVTLLVDRDGL

C17orf58

226

Q2M2W7
TLGRRLASELLLGLA

HERC1

241

Q15751
RSLDTGLRLLLVGII

PCNX4

516

Q63HM2
GTKLLERAGLVLRLL

KCNG2

276

Q9UJ96
LLLTAVDLLGRDRDG

PEX6

526

Q13608
QRDLSDGLRLIALLE

FLNC

61

Q14315
LLELAGRSLLRDQAL

PRAMEF15

11

P0DUQ1
LLRQDLGLERTLLPD

LRRC75B

56

Q2VPJ9
LRGGLLLQVGLSLLR

LY6L

121

H3BQJ8
QGLISLRILDLSRNL

LGR4

386

Q9BXB1
ATLVGLLLQRLAARL

SLC11A2

111

P49281
ILLLGSSLQELRRAL

OLIG1

161

Q8TAK6
LALRQVRAILEDLGL

HK3

801

P52790
GSNVDTLLRLRGRLL

HUWE1

3166

Q7Z6Z7
LLLEALARLSGRGVA

INF2

76

Q27J81
GNLLIILAIRSDTRL

OR1L1

91

Q8NH94
LGVLRNDIALLRLAS

PRSS41

141

Q7RTY9
LRLLLSGLVLGAALR

NPDC1

16

Q9NQX5
GIALALLGERLLALR

PON2

11

Q15165
LLGERLLALRNRLKA

PON2

16

Q15165
GSGQESRRLLLLLLL

PCDHA4

6

Q9UN74
LLAAGLLNLQRVGLL

PLEKHG6

186

Q3KR16
QRDLKRRLLILGGIL

CLDN22

111

Q8N7P3
RAKELLGQGLLLRSL

EIF3C

641

Q99613
LLGQGLLLRSLQERN

EIF3CL

646

B5ME19
TRNVGLLLIDTRLLR

DNAH6

666

Q9C0G6
GLERLLLSEQLSRLD

HTT

2881

P42858
LLRGLLALRDSGILF

KLHL22

36

Q53GT1
QGLLEERGRILLSLS

DOC2A

246

Q14183
LGLLGLRLSVTLNFR

EFCAB6

786

Q5THR3
LQTLRDIERLLLRSG

BCL9L

411

Q86UU0
LGLLLLLARSGTRAL

CRIM1

21

Q9NZV1
RGREALLVLLALLAL

GALNT12

16

Q8IXK2
SGLALRKLGDRVQLL

CCDC57

656

Q2TAC2
LELLLRQLGRDAGAT

ANKRD9

196

Q96BM1
LGRRLGALNSSLQLL

EMILIN1

786

Q9Y6C2
LSGRLRLGLAEQSVL

LIG1

446

P18858
DGRLDLNDLARILAL

SCGN

166

O76038
LVKLLSRGEGIRTLL

CACNA1D

1326

Q01668
LLAVGLALLVRKLRE

CRB3

71

Q9BUF7
ELALLQGLLGENRLL

NYNRIN

1271

Q9P2P1
LQLLKALRDLGARGL

ITPRIPL2

376

Q3MIP1
LRITRILKSLGELGL

OGFR

211

Q9NZT2
LELRKIGVRLNSLLG

MAP3K15

421

Q6ZN16
EQVLGLGALRKLLRL

HSPBP1

181

Q9NZL4
LGRLELLEEVLALGL

RSAD1

346

Q9HA92
TAALSLELLRRLGLI

SLC35D3

51

Q5M8T2
FLRTEQGLLLRALQL

SEMA3F

656

Q13275
QGLLLRALQLSDRGL

SEMA3F

661

Q13275
RDRLLTLLLLGALLS

FAM20A

6

Q96MK3
VELLGRRLLLLLGFS

SLC2A5

336

P22732
LEGDGLLLRERLAAL

MEX3C

41

Q5U5Q3
RVLGLLLLLGSRLAR

SHROOM1

711

Q2M3G4
LLELAGRSLLRDQAL

PRAMEF27

11

A3QJZ7
RILIDGISLGLTLRL

TBC1D3L

271

B9A6J9
RLRALDLLGRFLDLG

RPTOR

446

Q8N122
QLVLRRGLLLLGVFL

SLC47A1

541

Q96FL8
QTLLLDEERGRLLLG

SEMA3D

71

O95025
LELLNRDNVGLVLLL

ANGEL1

356

Q9UNK9
RILIDGISLGLTLRL

TBC1D3B

271

A6NDS4
RILIDGISLGLTLRL

TBC1D3H

271

P0C7X1
LLELAGRSLLRDQAL

PRAMEF4

11

O60810
RLLGKAGVLLLLRDS

TXNDC16

296

Q9P2K2
RLRALLRLIQGEQLL

PHF21B

481

Q96EK2
RDGRNLLRLLEVLSG

SPTBN2

86

O15020
RLDGGLDLLLRLLQA

SARM1

121

Q6SZW1
RILIDGISLGLTLRL

TBC1D3F

271

A6NER0
LLVSLRLEGGTVLAR

PLEKHG4B

401

Q96PX9
DLRGSLLSLREGQAL

TUT1

506

Q9H6E5
LLELAGRSLLRDQAL

PRAMEF9

11

P0DUQ2
GLVSLILLLLGRTRG

TRAV9-2

6

A0A087WT02
LSLGLEEELLQRGIR

TMPRSS9

101

Q7Z410
LLELAGRSLLRDQAL

PRAMEF11

11

O60813
RILIDGISLGLTLRL

TBC1D3E

271

A0A087X179
IGIGLLSLLLRDDRV

PSME4

1166

Q14997
KGLRETLSRNLELGL

SERPINA10

146

Q9UK55
RILIDGISLGLTLRL

TBC1D3D

271

A0A087WVF3
TGRLLRALLGLSLLF

PIEZO1

56

Q92508
RILIDGISLGLTLRL

TBC1D3G

271

Q6DHY5
RILIDGISLGLTLRL

TBC1D3

271

Q8IZP1
RILIDGISLGLTLRL

TBC1D3K

271

A0A087X1G2
RILIDGISLGLTLRL

TBC1D3I

271

A0A087WXS9
RILIDGISLGLTLRL

TBC1D3C

271

Q6IPX1
QQLLLGGELSRDLRL

ZCCHC12

176

Q6PEW1
SLLSVRLGGLFLRDL

VPS13D

546

Q5THJ4
VTALLGRLAELRQRL

KDM5C

1301

P41229
EAGEAVLLLREGLLR

KIAA2013

136

Q8IYS2
LLRAGADLSLLDRLG

NFKB1

601

P19838
LLLLLLLETGAQDVR

NECTIN2

21

Q92692