Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1 LRP2 LRP8	4.75e-06	16	42	3	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1 LRP2 LRP8	1.12e-05	21	42	3	GO:0030228
GeneOntologyMolecularFunction	cargo receptor activity	LRP1 LRP2 LRP8	7.58e-04	85	42	3	GO:0038024
GeneOntologyMolecularFunction	apolipoprotein binding	LRP1 LRP8	8.01e-04	20	42	2	GO:0034185
GeneOntologyMolecularFunction	calcium ion binding	LRP1 LRP2 EPS15 SMOC2 LOXL2 LRP8 NIN	8.71e-04	749	42	7	GO:0005509
GeneOntologyMolecularFunction	hormone binding	LRP2 NPR1 GLP2R	1.32e-03	103	42	3	GO:0042562
GeneOntologyBiologicalProcess	regulation of transforming growth factor beta receptor signaling pathway	LRP1 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	1.32e-07	192	43	7	GO:0017015
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	LRP1 LRP2 BCL9L ZEB1 ZFYVE9 SMOC2 BCL9 RBBP7 RNF111	1.43e-07	412	43	9	GO:0090287
GeneOntologyBiologicalProcess	regulation of cellular response to transforming growth factor beta stimulus	LRP1 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	1.46e-07	195	43	7	GO:1903844
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	LRP1 LRP2 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	5.14e-07	347	43	8	GO:0090092
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	LRP1 LRP2 BCL9L ZEB1 SETX ZFYVE9 SMOC2 BCL9 RBBP7 RNF111 LRP8	9.36e-07	850	43	11	GO:0071363
GeneOntologyBiologicalProcess	response to growth factor	LRP1 LRP2 BCL9L ZEB1 SETX ZFYVE9 SMOC2 BCL9 RBBP7 RNF111 LRP8	1.36e-06	883	43	11	GO:0070848
GeneOntologyBiologicalProcess	transforming growth factor beta receptor signaling pathway	LRP1 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	1.52e-06	276	43	7	GO:0007179
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	LRP1 LRP2 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	3.30e-06	445	43	8	GO:0141091
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	LRP1 LRP2 BCL9L NPR1 ZEB1 SETX ZFYVE9 SMOC2 BCL9 RBBP7 RNF111 NGEF	3.59e-06	1186	43	12	GO:0007167
GeneOntologyBiologicalProcess	cellular response to transforming growth factor beta stimulus	LRP1 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	5.57e-06	336	43	7	GO:0071560
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	LRP1 LRP2 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	5.93e-06	482	43	8	GO:0007178
GeneOntologyBiologicalProcess	response to transforming growth factor beta	LRP1 BCL9L ZEB1 ZFYVE9 BCL9 RBBP7 RNF111	6.37e-06	343	43	7	GO:0071559
GeneOntologyBiologicalProcess	chemoattraction of axon	LRP1 LRP2	4.23e-05	5	43	2	GO:0061642
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP1 LRP2	4.23e-05	5	43	2	GO:1905167
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LRP1 LRP2	8.86e-05	7	43	2	GO:1904352
GeneOntologyBiologicalProcess	regulation of lysosomal protein catabolic process	LRP1 LRP2	2.77e-04	12	43	2	GO:1905165
GeneOntologyBiologicalProcess	regulation of protein catabolic process in the vacuole	LRP1 LRP2	3.80e-04	14	43	2	GO:1904350
GeneOntologyBiologicalProcess	endosomal transport	LRP2 EPS15 ZFYVE9 BTBD8 PIK3C3	5.17e-04	320	43	5	GO:0016197
GeneOntologyCellularComponent	clathrin-coated pit	LRP1 LRP2 EPS15 BTBD8	2.19e-05	80	43	4	GO:0005905
GeneOntologyCellularComponent	endocytic vesicle membrane	LRP1 LRP2 EPS15 BTBD8 PIK3C3	7.20e-05	212	43	5	GO:0030666
GeneOntologyCellularComponent	axonal growth cone	LRP1 LRP2 NIN	1.08e-04	45	43	3	GO:0044295
GeneOntologyCellularComponent	growth cone	LRP1 LRP2 SETX NIN NGEF	1.42e-04	245	43	5	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	LRP1 LRP2 SETX NIN NGEF	1.65e-04	253	43	5	GO:0030427
GeneOntologyCellularComponent	beta-catenin-TCF complex	BCL9L BCL9	3.18e-04	13	43	2	GO:1990907
GeneOntologyCellularComponent	AP-2 adaptor complex	EPS15 BTBD8	3.70e-04	14	43	2	GO:0030122
GeneOntologyCellularComponent	clathrin coat of endocytic vesicle	EPS15 BTBD8	4.27e-04	15	43	2	GO:0030128
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	LRP2 EPS15 BTBD8	5.75e-04	79	43	3	GO:0030669
GeneOntologyCellularComponent	clathrin coat of coated pit	EPS15 BTBD8	8.47e-04	21	43	2	GO:0030132
GeneOntologyCellularComponent	endocytic vesicle	LRP1 LRP2 EPS15 BTBD8 PIK3C3	1.11e-03	384	43	5	GO:0030139
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle	LRP2 EPS15 BTBD8	1.17e-03	101	43	3	GO:0045334
GeneOntologyCellularComponent	clathrin-coated vesicle	LRP1 LRP2 EPS15 BTBD8	1.41e-03	237	43	4	GO:0030136
GeneOntologyCellularComponent	clathrin adaptor complex	EPS15 BTBD8	1.85e-03	31	43	2	GO:0030131
GeneOntologyCellularComponent	distal axon	LRP1 LRP2 SETX NIN NGEF	1.91e-03	435	43	5	GO:0150034
GeneOntologyCellularComponent	basement membrane	ALB SMOC2 LOXL2	2.02e-03	122	43	3	GO:0005604
GeneOntologyCellularComponent	axon	LRP1 LRP2 SETX BTBD8 LRP8 NIN NGEF	2.10e-03	891	43	7	GO:0030424
GeneOntologyCellularComponent	clathrin vesicle coat	EPS15 BTBD8	2.77e-03	38	43	2	GO:0030125
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	LRP2 EPS15 BTBD8	3.42e-03	147	43	3	GO:0030665
GeneOntologyCellularComponent	AP-type membrane coat adaptor complex	EPS15 BTBD8	4.39e-03	48	43	2	GO:0030119
Domain	Ldl_recept_b	LRP1 LRP2 LRP8	4.07e-06	14	43	3	PF00058
Domain	LDLRB	LRP1 LRP2 LRP8	4.07e-06	14	43	3	PS51120
Domain	LY	LRP1 LRP2 LRP8	5.07e-06	15	43	3	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP2 LRP8	5.07e-06	15	43	3	IPR000033
Domain	BCL9_beta-catenin-bd_dom	BCL9L BCL9	5.18e-06	2	43	2	IPR024670
Domain	BCL9	BCL9L BCL9	5.18e-06	2	43	2	PF11502
Domain	Bcl-9	BCL9L BCL9	5.18e-06	2	43	2	IPR015668
Domain	-	LRP1 LRP2 LRP8	9.80e-05	39	43	3	2.120.10.30
Domain	LDLR_class-A_CS	LRP1 LRP2 LRP8	1.06e-04	40	43	3	IPR023415
Domain	Ldl_recept_a	LRP1 LRP2 LRP8	1.51e-04	45	43	3	PF00057
Domain	-	LRP1 LRP2 LRP8	1.61e-04	46	43	3	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP1 LRP2 LRP8	1.61e-04	46	43	3	IPR011042
Domain	LDLRA_1	LRP1 LRP2 LRP8	1.83e-04	48	43	3	PS01209
Domain	LDrepeatLR_classA_rpt	LRP1 LRP2 LRP8	1.95e-04	49	43	3	IPR002172
Domain	LDLa	LRP1 LRP2 LRP8	1.95e-04	49	43	3	SM00192
Domain	LDLRA_2	LRP1 LRP2 LRP8	1.95e-04	49	43	3	PS50068
Domain	ZINC_FINGER_C2H2_2	ZNF286B DNAJC21 ZNF23 ZEB1 CPXCR1 ZNF382 ZNF655 ZNF518A	3.38e-04	775	43	8	PS50157
Domain	Znf_C2H2-like	ZNF286B DNAJC21 ZNF23 ZEB1 CPXCR1 ZNF382 ZNF655 ZNF518A	4.05e-04	796	43	8	IPR015880
Domain	Znf_C2H2	ZNF286B DNAJC21 ZNF23 ZEB1 CPXCR1 ZNF382 ZNF655 ZNF518A	4.36e-04	805	43	8	IPR007087
Domain	ZnF_C2H2	ZNF286B DNAJC21 ZNF23 ZEB1 CPXCR1 ZNF382 ZNF655 ZNF518A	4.47e-04	808	43	8	SM00355
Domain	Znf_C2H2/integrase_DNA-bd	ZNF286B DNAJC21 ZNF23 ZEB1 ZNF382 ZNF655 ZNF518A	9.53e-04	694	43	7	IPR013087
Domain	EGF_CA	LRP1 LRP2 LRP8	1.02e-03	86	43	3	PF07645
Domain	EGF_Ca-bd_CS	LRP1 LRP2 LRP8	1.44e-03	97	43	3	IPR018097
Domain	EGF_CA	LRP1 LRP2 LRP8	1.53e-03	99	43	3	PS01187
Domain	ASX_HYDROXYL	LRP1 LRP2 LRP8	1.57e-03	100	43	3	PS00010
Domain	cEGF	LRP1 LRP2	1.62e-03	26	43	2	IPR026823
Domain	cEGF	LRP1 LRP2	1.62e-03	26	43	2	PF12662
Domain	ZINC_FINGER_C2H2_1	ZNF286B DNAJC21 ZNF23 ZEB1 ZNF382 ZNF655 ZNF518A	1.83e-03	777	43	7	PS00028
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1 LRP2 LRP8	1.86e-03	106	43	3	IPR000152
Domain	FYVE	ZFYVE9 FGD6	2.02e-03	29	43	2	PF01363
Domain	FYVE	ZFYVE9 FGD6	2.02e-03	29	43	2	SM00064
Domain	EGF_3	LRP1 LRP2 VWDE LRP8	2.05e-03	235	43	4	PS50026
Domain	EGF	LRP1 LRP2 VWDE LRP8	2.05e-03	235	43	4	SM00181
Domain	EGF-like_dom	LRP1 LRP2 VWDE LRP8	2.53e-03	249	43	4	IPR000742
Domain	EGF_1	LRP1 LRP2 VWDE LRP8	2.76e-03	255	43	4	PS00022
Domain	Znf_FYVE-rel	ZFYVE9 FGD6	2.77e-03	34	43	2	IPR017455
Domain	EGF_CA	LRP1 LRP2 LRP8	2.77e-03	122	43	3	SM00179
Domain	EGF-like_Ca-bd_dom	LRP1 LRP2 LRP8	2.90e-03	124	43	3	IPR001881
Domain	EGF-like_CS	LRP1 LRP2 VWDE LRP8	3.00e-03	261	43	4	IPR013032
Domain	EGF	LRP1 LRP2 LRP8	3.04e-03	126	43	3	PF00008
Domain	EGF_2	LRP1 LRP2 VWDE LRP8	3.17e-03	265	43	4	PS01186
Domain	Znf_FYVE	ZFYVE9 FGD6	3.45e-03	38	43	2	IPR000306
Domain	ZF_FYVE	ZFYVE9 FGD6	3.82e-03	40	43	2	PS50178
Domain	Growth_fac_rcpt_	LRP1 LRP2 LRP8	5.52e-03	156	43	3	IPR009030
Domain	zf-RING_2	SCAF11 RNF111	6.38e-03	52	43	2	PF13639
Domain	RhoGEF	FGD6 NGEF	1.07e-02	68	43	2	SM00325
Domain	DH_2	FGD6 NGEF	1.13e-02	70	43	2	PS50010
Domain	RhoGEF	FGD6 NGEF	1.13e-02	70	43	2	PF00621
Domain	DH-domain	FGD6 NGEF	1.16e-02	71	43	2	IPR000219
Domain	-	FGD6 NGEF	1.16e-02	71	43	2	1.20.900.10
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	LRP1 LRP2 EPS15 ZFYVE9 BTBD8 PIK3C3 LOXL2 LRP8	2.59e-06	381	34	8	M48063
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	LRP1 LRP2 PDE6A LRP8	9.39e-05	100	34	4	M27158
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	LRP1 LRP2 LRP8	1.70e-04	45	34	3	MM15344
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	LRP1 LRP2 LRP8	2.06e-04	48	34	3	M27642
Pubmed	ApoER2 is endocytosed by a clathrin-mediated process involving the adaptor protein Dab2 independent of its Rafts' association.	LRP1 LRP2 LRP8	1.89e-08	5	44	3	16101684
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP1 LRP2 LRP8	6.59e-08	7	44	3	12169628
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP1 LRP2 LRP8	6.81e-07	14	44	3	17389516
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP1 LRP2 LRP8	1.52e-06	18	44	3	10827173
Pubmed	Identification of a homozygous missense mutation in LRP2 and a hemizygous missense mutation in TSPYL2 in a family with mild intellectual disability.	LRP2 TSPYL2	1.56e-06	2	44	2	26529358
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	1.56e-06	2	44	2	34445520
Pubmed	Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.	LRP1 LRP8	1.56e-06	2	44	2	12871934
Pubmed	Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.	BCL9L BCL9	1.56e-06	2	44	2	20682801
Pubmed	Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.	BCL9L BCL9	1.56e-06	2	44	2	38811552
Pubmed	BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.	BCL9L BCL9	1.56e-06	2	44	2	33767438
Pubmed	Megalin/gp330 mediates uptake of albumin in renal proximal tubule.	LRP2 ALB	1.56e-06	2	44	2	8898021
Pubmed	Mechanisms of albumin uptake by proximal tubular cells.	LRP2 ALB	1.56e-06	2	44	2	11158855
Pubmed	Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.	BCL9L BCL9	1.56e-06	2	44	2	15371335
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	LRP1 EPS15 SCAF11 AMER1 SMOC2 PIK3C3 LOXL2 DNAH14 LRP8 TSPYL2 NGEF	1.78e-06	1489	44	11	28611215
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	LRP2 DNAJC21 EPS15 ZFYVE9 USP48 TEFM RNF111	2.28e-06	481	44	7	28190767
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1 LRP2 LRP8	2.47e-06	21	44	3	21337463
Pubmed	Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1.	NPR1 ZEB1	4.69e-06	3	44	2	26934489
Pubmed	Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.	LRP1 LRP8	4.69e-06	3	44	2	24251389
Pubmed	The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.	BCL9L BCL9	4.69e-06	3	44	2	34545187
Pubmed	Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.	BCL9L BCL9	4.69e-06	3	44	2	33649334
Pubmed	Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease.	LRP2 ALB	4.69e-06	3	44	2	28356267
Pubmed	Cubilin is an albumin binding protein important for renal tubular albumin reabsorption.	LRP2 ALB	4.69e-06	3	44	2	10811843
Pubmed	Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.	LRP2 LRP8	4.69e-06	3	44	2	18174160
Pubmed	Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.	BCL9L BCL9	4.69e-06	3	44	2	20637214
Pubmed	Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.	LRP1 LRP8	4.69e-06	3	44	2	12807892
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1 LRP2 NPR1 LRP8	8.32e-06	101	44	4	23382219
Pubmed	ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis.	ZEB1 LOXL2	9.37e-06	4	44	2	27694892
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP1 LRP2	9.37e-06	4	44	2	7775583
Pubmed	Maternal-fetal transfer of selenium in the mouse.	LRP2 LRP8	9.37e-06	4	44	2	23651543
Pubmed	Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E.	LRP1 LRP2	9.37e-06	4	44	2	11421580
Pubmed	Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.	LRP1 LRP2	9.37e-06	4	44	2	12413896
Pubmed	SARA and RNF11 at the crossroads of EGFR signaling and trafficking.	EPS15 ZFYVE9	9.37e-06	4	44	2	24377927
Pubmed	Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.	LRP2 LRP8	9.37e-06	4	44	2	24760755
Pubmed	BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.	BCL9L BCL9	9.37e-06	4	44	2	19699733
Pubmed	Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.	BCL9L BCL9	1.56e-05	5	44	2	30760710
Pubmed	Crystal structure of a beta-catenin/BCL9/Tcf4 complex.	BCL9L BCL9	1.56e-05	5	44	2	17052462
Pubmed	LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.	BCL9L BCL9	1.56e-05	5	44	2	24360964
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2	1.56e-05	5	44	2	19047013
Pubmed	TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.	BCL9L BCL9	1.56e-05	5	44	2	32808927
Pubmed	A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.	BCL9L BCL9	1.56e-05	5	44	2	19328798
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP1 LRP2	1.56e-05	5	44	2	18685438
Pubmed	Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.	BCL9L BCL9	2.34e-05	6	44	2	30760720
Pubmed	BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.	BCL9L BCL9	2.34e-05	6	44	2	17113272
Pubmed	Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.	BCL9L BCL9	2.34e-05	6	44	2	15574752
Pubmed	Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.	BCL9L BCL9	2.34e-05	6	44	2	25184676
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP1 LRP2	2.34e-05	6	44	2	9837937
Pubmed	Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.	BCL9L BCL9	3.27e-05	7	44	2	30366904
Pubmed	Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.	LRP1 LRP8	4.36e-05	8	44	2	10380922
Pubmed	Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.	BCL9L BCL9	4.36e-05	8	44	2	28296634
Pubmed	LDL receptor-related protein as a component of the midkine receptor.	LRP1 LRP2	5.60e-05	9	44	2	10772929
Pubmed	APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.	LRP1 LRP8	5.60e-05	9	44	2	23986861
Pubmed	SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking.	EPS15 ZFYVE9	5.60e-05	9	44	2	23222715
Pubmed	HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.	ALB PIK3C3	5.60e-05	9	44	2	29558368
Pubmed	APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.	PIK3C3 RBBP7	5.60e-05	9	44	2	15016378
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	LRP1 LRP8	5.60e-05	9	44	2	20005821
Pubmed	Genome-wide association analysis identifies susceptibility loci for migraine without aura.	LRP1 PHACTR1	6.99e-05	10	44	2	22683712
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1 LRP2	8.54e-05	11	44	2	24639464
Pubmed	Functional proteomics mapping of a human signaling pathway.	LRP1 EPS15 NPR1 ZFYVE9 ZNF518A RNF111	9.57e-05	591	44	6	15231748
Pubmed	Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.	LRP1 LRP2	1.41e-04	14	44	2	15082773
Pubmed	A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.	BCL9L BCL9	1.41e-04	14	44	2	28174279
Pubmed	The WTX Tumor Suppressor Interacts with the Transcriptional Corepressor TRIM28.	AMER1 RBBP7	1.63e-04	15	44	2	25882849
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	SETX RBBP7	2.36e-04	18	44	2	20064376
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	BCL9L SCAF11 SETX RBBP7 TSPYL2	3.07e-04	469	44	5	27634302
Pubmed	Temporal and spatial transcriptional programs in murine kidney development.	ALB SMOC2	3.24e-04	21	44	2	15998744
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	LRP2 ALB	4.24e-04	24	44	2	31740596
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	PMS1 LRP1	4.24e-04	24	44	2	17452356
Pubmed	Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.	LRP2 TRPV5	5.79e-04	28	44	2	28847650
Pubmed	Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.	ZNF23 SMOC2	6.21e-04	29	44	2	16966370
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	LRP1 ZEB1	7.11e-04	31	44	2	32546759
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ZNF286B AMER1 SETX PIK3C3 FGD6 RBBP7	7.16e-04	861	44	6	36931259
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	LRP1 ZEB1 RBBP7 ZNF655 RETREG3 ZNF518A RNF111	7.28e-04	1203	44	7	29180619
Pubmed	Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.	LRP2 TRPV5	8.55e-04	34	44	2	35341793
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PMS1 SCAF11 SETX USP48 RBBP7	9.93e-04	608	44	5	36089195
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L ALB ZEB1 BCL9	1.01e-03	351	44	4	38297188
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	LRP1 LRP2 LRRCC1 ZNF655 RNF111 TSPYL2 NGEF	1.07e-03	1285	44	7	35914814
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LRP1 ALB LOXL2	1.18e-03	164	44	3	32409323
Interaction	APBA2 interactions	LRP1 LRP2 ZNF518A LRP8	3.58e-06	48	44	4	int:APBA2
Interaction	CUBN interactions	LRP1 LRP2 ALB	4.34e-06	15	44	3	int:CUBN
Interaction	SCN3A interactions	LRP1 LRP2 LRP8	5.33e-06	16	44	3	int:SCN3A
Interaction	MAPK8IP1 interactions	LRP1 LRP2 SETX LRP8	7.69e-06	58	44	4	int:MAPK8IP1
Interaction	NTN5 interactions	LRP2 AMER1 VWDE	1.90e-05	24	44	3	int:NTN5
Interaction	LRPAP1 interactions	LRP1 LRP2 ZFYVE9 LRP8 NGEF	4.40e-05	180	44	5	int:LRPAP1
Interaction	UBC interactions	LRP2 DNAJC21 EPS15 ZFYVE9 USP48 TEFM RNF111	4.68e-05	446	44	7	int:UBC
Interaction	ITGB1BP1 interactions	LRP1 LRP2 LRP8	5.06e-05	33	44	3	int:ITGB1BP1
Cytoband	1p34	GJA9 LRP8	4.37e-04	32	44	2	1p34
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	EPS15 ZFYVE9 LRP8	4.52e-04	155	44	3	chr1p32
Cytoband	7q35	ARHGEF35 TRPV5	1.29e-03	55	44	2	7q35
GeneFamily	Low density lipoprotein receptors	LRP1 LRP2 LRP8	1.42e-06	13	32	3	634
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF35 FGD6 NGEF	2.14e-04	66	32	3	722
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE9 FGD6	1.37e-03	31	32	2	81
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF286B ZNF23 ZEB1 ZNF382 ZNF655 ZNF518A	1.44e-03	718	32	6	28
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRP1 LRRCC1 NPR1 SPACA1 NGEF	7.85e-07	174	44	5	1d157f7a919c8246e83d8060d2a0017c6c781ef3
Disease	migraine without aura	LRP1 PHACTR1	1.88e-05	5	41	2	MONDO_0100431
Disease	Common Migraine	LRP1 PHACTR1	3.94e-05	7	41	2	C0338480
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	LRP1 PHACTR1	6.74e-05	9	41	2	EFO_0005763, MONDO_0011847
Disease	Endometrial Carcinoma	PMS1 ZEB1 TSPYL2	1.39e-04	72	41	3	C0476089
Disease	migraine without aura, susceptibility to, 4	LRP1 PHACTR1	2.23e-04	16	41	2	MONDO_0011847
Disease	Kidney Diseases	LRP2 NPR1 ALB	2.52e-04	88	41	3	C0022658
Disease	cervical artery dissection	LRP1 PHACTR1	2.53e-04	17	41	2	EFO_1000059
Disease	myocardial infarction (is_implicated_in)	LRP1 NPR1 LRP8	3.56e-04	99	41	3	DOID:5844 (is_implicated_in)
Disease	Antimigraine preparation use measurement	LRP1 PHACTR1	3.89e-04	21	41	2	EFO_0009939
Disease	Unipolar Depression	LRP1 ALB BCL9 LRP8	4.55e-04	259	41	4	C0041696
Disease	migraine disorder, pulse pressure measurement	LRP1 PHACTR1	5.99e-04	26	41	2	EFO_0005763, MONDO_0005277
Disease	glomerular filtration rate, response to platinum based chemotherapy	BCL9 PHACTR1	6.96e-04	28	41	2	EFO_0004647, EFO_0005208
Disease	spontaneous coronary artery dissection	LRP1 PHACTR1	8.54e-04	31	41	2	EFO_0010820
Disease	ovarian neoplasm	PMS1 ZEB1 BCL9	8.60e-04	134	41	3	C0919267
Disease	Malignant neoplasm of ovary	PMS1 ZEB1 BCL9	9.17e-04	137	41	3	C1140680
Disease	coronary artery disease	LRP1 SCAF11 ZEB1 USP48 FGD6 VWDE PHACTR1	1.18e-03	1194	41	7	EFO_0001645
Disease	aspirin use measurement	FGD6 PHACTR1	1.35e-03	39	41	2	EFO_0007013
Disease	response to anticoagulant	SMOC2 BCL9	1.49e-03	41	41	2	GO_0061476
Disease	Secondary Biliary Cholangitis	ALB LOXL2	1.57e-03	42	41	2	C0238065

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERNECFLQHKDDNPN	ALB	121	P02768
CEEHPAETNQNEGAE	ARHGEF35	186	A5YM69
KCEENPEFHNDEDLA	AMER1	821	Q5JTC6
GFDNEDPACNQDHLS	NPR1	456	P16066
HKNSENEPPNDCSTD	CPXCR1	16	Q8N123
ENDCHDQSDEAPKNP	LRP1	2881	Q07954
KFNAESQGCNHEEDA	LOXL2	406	Q9Y4K0
ANVPNTEEDEHFCDF	PDE6A	151	P16499
NGVDNCHDNNTSDEK	LRP2	2801	P98164
CHDNNTSDEKNCPDR	LRP2	2806	P98164
HPDKNLDNAAEAAEQ	DNAJC21	31	Q5F1R6
PNDDAQFDASHCDSD	RBBP7	86	Q16576
ECDDNKENVPHESDY	PHACTR1	371	Q9C0D0
DSECSENHSFKQNVD	GLP2R	156	O95838
FQPNPDNHSVNDEKC	GJA9	306	P57773
NSSDCSLQKHEIPED	BTBD8	156	Q5XKL5
PNDDSDIKECNSADH	BCL9	116	O00512
SEEDDKPIGATHNCN	BCL9L	166	Q86UU0
NSKENFHESDQCPEE	DNAH14	551	Q0VDD8
CSELDNNRHSKEEDP	EPS15	586	P42566
NNRHSKEEDPFNVDS	EPS15	591	P42566
DADDPNSADKHRNDC	SCAF11	1006	Q99590
SHPLAFECDTLDNNE	SPACA1	176	Q9HBV2
NDESGKNTDDCLNHQ	PMS1	396	P54277
KHCNQEQDCPDGSDE	LRP8	316	Q14114
NEEHFQEPDCSLEAQ	NIN	81	Q8N4C6
CEDQDTQQRDPKTHE	PIK3C3	501	Q8NEB9
TSQADQDIQDKEPHC	NGEF	41	Q8N5V2
HPDDNNSVQDGEKKC	SETX	1096	Q7Z333
NVTFCDENAKEPENA	TEFM	46	Q96QE5
NHSDSEEELAAFCPQ	RETREG3	256	Q86VR2
GTFDENPENDFHDKN	VWDE	566	Q8N2E2
DINENICDSENPDHN	TSPYL2	471	Q9H2G4
GNEFSHLCDDSQKQE	RNF111	61	Q6ZNA4
CDQEHQSALEEAKQP	SMOC2	216	Q9H3U7
EHFETCQDDSEKSNN	FGD6	251	Q6ZV73
RLHCENNDKAPESES	ZNF518A	376	Q6AHZ1
ECESDAENEQNHDPN	ZEB1	111	P37275
ETFTSEKNNECHEPE	ZNF655	121	Q8N720
ENEGNLHFQCPSDVE	ZNF286B	101	P0CG31
HQENNTEEKPYQCSE	ZNF23	186	P17027
QAPEQPFDHNECEKS	ZNF382	206	Q96SR6
EIDENSFHNIDDPNC	USP48	66	Q86UV5
FLENDDQHNCLSDPA	ZFYVE9	1316	O95405
FKNSDKEDDQEHPSE	TRPV5	651	Q9NQA5
VCQSSEPEKNNHEND	LRRCC1	276	Q9C099