Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acyltransferase activity	RC3H2 BRPF3 BRCA2 EGR2 WWP2 SIAH2 BFAR OXSM HERC2 ZDHHC17 TTC3 RFWD3	7.33e-05	775	82	12	GO:0016746
MousePheno	increased salivary adenocarcinoma incidence	GON4L YY1AP1	2.20e-05	2	66	2	MP:0000621
MousePheno	postnatal lethality	PIKFYVE GMNC NEK1 RC3H2 FRAS1 MAP1B BRCA2 GAS2L3 EGR2 EGR3 SLC35C1 NFKBIA PRMT3 HERC2 HCFC1 TNS3	3.22e-05	1084	66	16	MP:0002082
Domain	DUF3446	EGR2 EGR3	5.84e-05	3	83	2	IPR021849
Domain	DUF3446	EGR2 EGR3	5.84e-05	3	83	2	PF11928
Domain	-	PIKFYVE RC3H2 BRPF3 PHF3 ASH1L SIAH2 BFAR TTC3 RFWD3	1.69e-04	449	83	9	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PIKFYVE RC3H2 BRPF3 PHF3 ASH1L SIAH2 BFAR TTC3 RFWD3	1.99e-04	459	83	9	IPR013083
Domain	TNF_CS	CD40LG TNF	1.05e-03	11	83	2	IPR021184
Domain	ZINC_FINGER_C2H2_2	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 PRMT3 ZNF625 ZNF236	2.25e-03	775	83	10	PS50157
Domain	ZINC_FINGER_C2H2_1	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 PRMT3 ZNF625 ZNF236	2.29e-03	777	83	10	PS00028
Domain	TNF_1	CD40LG TNF	2.54e-03	17	83	2	PS00251
Domain	Znf_C2H2-like	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 PRMT3 ZNF625 ZNF236	2.73e-03	796	83	10	IPR015880
Domain	TNF	CD40LG TNF	2.85e-03	18	83	2	SM00207
Domain	Znf_C2H2	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 PRMT3 ZNF625 ZNF236	2.96e-03	805	83	10	IPR007087
Domain	Zinc_finger_PHD-type_CS	BRPF3 PHF3 ASH1L	3.03e-03	65	83	3	IPR019786
Domain	ZnF_C2H2	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 PRMT3 ZNF625 ZNF236	3.04e-03	808	83	10	SM00355
Domain	-	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 ZNF625 ZNF236	3.14e-03	679	83	9	3.30.160.60
Domain	VWC_out	FRAS1 MUC5AC	3.18e-03	19	83	2	SM00215
Domain	TNF	CD40LG TNF	3.18e-03	19	83	2	PF00229
Domain	TNF_dom	CD40LG TNF	3.18e-03	19	83	2	IPR006052
Domain	TNF_2	CD40LG TNF	3.18e-03	19	83	2	PS50049
Domain	zf-C2H2	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 ZNF625 ZNF236	3.60e-03	693	83	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 ZNF625 ZNF236	3.63e-03	694	83	9	IPR013087
Domain	Znf_FYVE_PHD	PIKFYVE BRPF3 PHF3 ASH1L	4.18e-03	147	83	4	IPR011011
Domain	PHD	BRPF3 PHF3 ASH1L	4.54e-03	75	83	3	PF00628
Domain	zf-CCHC	RBM4B RBM4	4.65e-03	23	83	2	PF00098
Domain	Znf_PHD-finger	BRPF3 PHF3 ASH1L	5.25e-03	79	83	3	IPR019787
Domain	-	RBM4B RBM4	5.92e-03	26	83	2	4.10.60.10
Domain	C2_dom	CEP120 MCTP1 WWP2 TNS3	6.15e-03	164	83	4	IPR000008
Domain	HECT	WWP2 HERC2	6.37e-03	27	83	2	PF00632
Domain	HECTc	WWP2 HERC2	6.37e-03	27	83	2	SM00119
Domain	HECT_dom	WWP2 HERC2	6.37e-03	27	83	2	IPR000569
Domain	HECT	WWP2 HERC2	6.37e-03	27	83	2	PS50237
Pathway	PID_NFAT_TFPATHWAY	EGR2 EGR3 CD40LG TNF	2.95e-05	45	56	4	M60
Pathway	BIOCARTA_VIP_PATHWAY	EGR2 EGR3 NFKBIA	1.28e-04	25	56	3	MM1441
Pathway	BIOCARTA_VIP_PATHWAY	EGR2 EGR3 NFKBIA	1.45e-04	26	56	3	M17941
Pubmed	A human MAP kinase interactome.	CASP8AP2 JUP HIVEP1 CEP95 RBM4B PLEKHA5 YY1AP1 NCKAP5 HERC2 RAPGEF2 ZDHHC17 MGA	2.20e-09	486	84	12	20936779
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NEK1 JUP PHLDB1 HIVEP1 MAP1B PHF3 CEP95 WWP2 EPB41L5 PLEKHA5 RAPGEF2 LYST TNS3 KIAA0753	1.87e-08	861	84	14	36931259
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	NEK1 URI1 WDR33 RBM4B WWP2 EPB41L5 SIAH2 PRMT3 FRMPD3 HERC2 SDK1	6.70e-08	533	84	11	25544563
Pubmed	Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.	EGR2 EGR3 TNF	2.70e-07	6	84	3	14560009
Pubmed	Digital quantification of human eye color highlights genetic association of three new loci.	HERC2 TTC3 LYST	2.70e-07	6	84	3	20463881
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	FRAS1 MAP1B ZNF665 RBM4 ATG2B EPB41L5 OXSM HERC2 HCFC1 OMG	4.65e-07	513	84	10	25798074
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RC3H2 FRAS1 MAP1B MARF1 GON4L PLEKHA5 YY1AP1 QSER1 ZDHHC17 HCFC1 RFWD3	4.83e-07	650	84	11	38777146
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	NEK1 JUP MAP1B WDR33 PHF3 ATG2B PLEKHA5 QSER1 MGA HCFC1	8.59e-07	549	84	10	38280479
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FANCG NEK1 PHLDB1 URI1 RBM4 NFKBIA RTN3 CRYBG1 PLEKHA5 PRMT3 RAPGEF2 TNS3 RFWD3	1.22e-06	1038	84	13	26673895
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	BRCA2 WDR33 RBM4B QSER1 MGA HCFC1	1.53e-06	146	84	6	23892456
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIKFYVE WDR33 PHF3 RBM4 EPB41L5 PLEKHA5 DGKE QSER1 MGA HCFC1 TNS3	1.56e-06	733	84	11	34672954
Pubmed	Functional proteomics mapping of a human signaling pathway.	JUP HIVEP1 RBM4 WWP2 ASH1L SIAH2 HERC2 TTC3 MGA SDK1	1.66e-06	591	84	10	15231748
Pubmed	HIV-1 subtypes B and C Tat differentially impact synaptic plasticity expression and implicates HIV-associated neurocognitive disorders.	EGR2 EGR3 TNF ADCY1	2.19e-06	38	84	4	25613138
Pubmed	Developmentally regulated tumor necrosis factor-alpha induced nuclear factor-kappaB activation in intestinal epithelium.	NFKBIA TNF	5.76e-06	2	84	2	17307728
Pubmed	1,25-Dihydroxyvitamin D₃ suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation.	NFKBIA TNF	5.76e-06	2	84	2	21176770
Pubmed	NFκB and MAPK signalling pathways mediate TNFα-induced Early Growth Response gene transcription leading to aromatase expression.	EGR2 EGR3	5.76e-06	2	84	2	23485457
Pubmed	Newly identified Gon4l/Udu-interacting proteins implicate novel functions.	GON4L YY1AP1	5.76e-06	2	84	2	32848183
Pubmed	Cleavage of the CD11b extracellular domain by the leukocyte serprocidins is critical for neutrophil detachment during chemotaxis.	ITGAM LYST	5.76e-06	2	84	2	21403131
Pubmed	Phylogenetic and molecular characterization of the splicing factor RBM4.	RBM4B RBM4	5.76e-06	2	84	2	23527094
Pubmed	The transcriptional regulator GON4L is required for viability and hematopoiesis in mice.	GON4L YY1AP1	5.76e-06	2	84	2	33864850
Pubmed	Binding of CD40L to Mac-1's I-domain involves the EQLKKSKTL motif and mediates leukocyte recruitment and atherosclerosis--but does not affect immunity and thrombosis in mice.	CD40LG ITGAM	5.76e-06	2	84	2	21998326
Pubmed	A novel 4,6-disubstituted-1,2,4-triazolo-1,3,4-thiadiazole derivative inhibits tumor cell invasion and potentiates the apoptotic effect of TNFα by abrogating NF-κB activation cascade.	NFKBIA TNF	5.76e-06	2	84	2	27882436
Pubmed	Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.	EGR2 EGR3	5.76e-06	2	84	2	28487311
Pubmed	Cardioprotection afforded by NF-kappaB ablation is associated with activation of Akt in mice overexpressing TNF-alpha.	NFKBIA TNF	5.76e-06	2	84	2	16199483
Pubmed	Effects of representative glucocorticoids on TNFα- and CD40L-induced NF-κB activation in sensor cells.	CD40LG TNF	5.76e-06	2	84	2	24747770
Pubmed	Emerging roles of Egr2 and Egr3 in the control of systemic autoimmunity.	EGR2 EGR3	5.76e-06	2	84	2	27856665
Pubmed	Inducible degradation of I kappa B alpha in vitro and in vivo requires the acidic C-terminal domain of the protein.	NFKBIA TNF	5.76e-06	2	84	2	7739525
Pubmed	T cells responding to Trypanosoma cruzi detected by membrane TNF-α and CD154 in chagasic patients.	CD40LG TNF	5.76e-06	2	84	2	28967229
Pubmed	The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.	GON4L YY1AP1	5.76e-06	2	84	2	20530203
Pubmed	The LARK/RBM4a protein is highly expressed in cerebellum as compared to cerebrum.	RBM4B RBM4	5.76e-06	2	84	2	18708123
Pubmed	E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells.	BRCA2 RFWD3	5.76e-06	2	84	2	32391871
Pubmed	Suppression of tumour necrosis factor-alpha by Schizonepeta tenuifolia water extract via inhibition of IkappaBalpha degradation and Jun N-terminal kinase/stress-activated protein kinase activation.	NFKBIA TNF	5.76e-06	2	84	2	20663042
Pubmed	Differential effects of tumor necrosis factor-alpha and CD40L on NF-kappa B inhibitory proteins I kappa B alpha, beta and epsilon and on the induction of the Jun amino-terminal kinase pathway in Ramos Burkitt lymphoma cells.	CD40LG TNF	5.76e-06	2	84	2	16464740
Pubmed	EGR3 as a potential susceptibility gene for schizophrenia in Korea.	EGR2 EGR3	5.76e-06	2	84	2	20687139
Pubmed	Egr-2 and Egr-3 are negative regulators of T cell activation.	EGR2 EGR3	5.76e-06	2	84	2	15834410
Pubmed	Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.	EGR2 EGR3	5.76e-06	2	84	2	29314730
Pubmed	Relative levels of the inflammatory cytokine TNFα and the soluble CD40 ligand profile in serum correlate with the thyrotoxic activity of Graves' disease.	CD40LG TNF	5.76e-06	2	84	2	22512415
Pubmed	CEP120-mediated KIAA0753 recruitment onto centrioles is required for timely neuronal differentiation and germinal zone exit in the developing cerebellum.	CEP120 KIAA0753	5.76e-06	2	84	2	34711653
Pubmed	CR3 (CD11b/CD18) is the major macrophage receptor for IgM antibody-mediated phagocytosis of African trypanosomes: diverse effect on subsequent synthesis of tumor necrosis factor alpha and nitric oxide.	TNF ITGAM	5.76e-06	2	84	2	16616573
Pubmed	Tumour necrosis factor alpha upregulates platelet CD40L in patients with heart failure.	CD40LG TNF	5.76e-06	2	84	2	18281372
Pubmed	The transcription factors Egr2 and Egr3 are essential for the control of inflammation and antigen-induced proliferation of B and T cells.	EGR2 EGR3	5.76e-06	2	84	2	23021953
Pubmed	Direct interaction of the Fanconi anaemia protein FANCG with BRCA2/FANCD1.	FANCG BRCA2	5.76e-06	2	84	2	12915460
Pubmed	Suppression of TNF-alpha-induced apoptosis by NF-kappaB.	NFKBIA TNF	5.76e-06	2	84	2	8864120
Pubmed	Impaired CD40L signaling is a cause of defective IL-12 and TNF-alpha production in Sézary syndrome: circumvention by hexameric soluble CD40L.	CD40LG TNF	5.76e-06	2	84	2	15315967
Pubmed	The Npro product of classical swine fever virus interacts with IkappaBalpha, the NF-kappaB inhibitor.	NFKBIA TNF	5.76e-06	2	84	2	18632959
Pubmed	Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells.	EGR2 EGR3	5.76e-06	2	84	2	32709717
Pubmed	Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.	EGR2 EGR3	5.76e-06	2	84	2	36342511
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	NEK1 CEP120 MAP1B GAS2L3 PHF3 RBM4B ASH1L MGA OMG KIAA0753	6.45e-06	689	84	10	36543142
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 NEK1 JUP HIVEP1 BRCA2 ATG2B PLEKHA5 MGA	8.00e-06	418	84	8	34709266
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	NEK1 RC3H2 ATG2B PLEKHA5 PRMT3 TNS3	1.21e-05	209	84	6	36779422
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN PHLDB1 URI1 MAP1B ATXN7L1 RBM4 WWP2 ASH1L RTN3 QSER1 RAPGEF2 ZNF236 TTC3 ADCY1	1.25e-05	1489	84	14	28611215
Pubmed	Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease.	NFKBIA ITGAM	1.73e-05	3	84	2	26758846
Pubmed	Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division.	GON4L YY1AP1	1.73e-05	3	84	2	28381640
Pubmed	Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation.	RC3H2 TNF	1.73e-05	3	84	2	23583642
Pubmed	Cloning and tissue expression of the mouse ortholog of AIM1, a betagamma-crystallin superfamily member.	EGR2 CRYBG1	1.73e-05	3	84	2	9716656
Pubmed	Uncontrolled CD21low age-associated and B1 B cell accumulation caused by failure of an EGR2/3 tolerance checkpoint.	EGR2 EGR3	1.73e-05	3	84	2	35045301
Pubmed	Interruption of classic CD40L-CD40 signalling but not of the novel CD40L-Mac-1 interaction limits arterial neointima formation in mice.	CD40LG ITGAM	1.73e-05	3	84	2	24652469
Pubmed	GRK6 phosphorylates IκBα at Ser(32)/Ser(36) and enhances TNF-α-induced inflammation.	NFKBIA TNF	1.73e-05	3	84	2	25881508
Pubmed	RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.	RBM4B RBM4	1.73e-05	3	84	2	27821480
Pubmed	CD40/CD40 ligand interactions and TNFα treatment reduce activity of P105 promoter of the human papilloma virus-18 in vitro.	CD40LG TNF	1.73e-05	3	84	2	27031714
Pubmed	Induction of murine macrophage TNF-alpha synthesis by Mycobacterium avium is modulated through complement-dependent interaction via complement receptors 3 and 4 in relation to M. avium glycopeptidolipid.	TNF ITGAM	1.73e-05	3	84	2	15899409
Pubmed	Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst.	CD40LG ITGAM	1.73e-05	3	84	2	23785403
Pubmed	A conserved interaction that is essential for the biogenesis of histone locus bodies.	CASP8AP2 GON4L	1.73e-05	3	84	2	25339177
Pubmed	Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors.	EGR2 EGR3	1.73e-05	3	84	2	19706684
Pubmed	Cooperation of TNF family members CD40 ligand, receptor activator of NF-kappa B ligand, and TNF-alpha in the activation of dendritic cells and the expansion of viral specific CD8+ T cell memory responses in HIV-1-infected and HIV-1-uninfected individuals.	CD40LG TNF	1.73e-05	3	84	2	12574344
Pubmed	Early growth response transcriptional regulators are dispensable for macrophage differentiation.	EGR2 EGR3	1.73e-05	3	84	2	17312150
Pubmed	Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing.	NFKBIA TNF	1.73e-05	3	84	2	20581820
Pubmed	Glucose ingestion induces an increase in intranuclear nuclear factor kappaB, a fall in cellular inhibitor kappaB, and an increase in tumor necrosis factor alpha messenger RNA by mononuclear cells in healthy human subjects.	NFKBIA TNF	1.73e-05	3	84	2	16919536
Pubmed	α-Melanocyte-stimulating hormone inhibits tumor necrosis factor α-stimulated MUC5AC expression in human nasal epithelial cells.	TNF MUC5AC	1.73e-05	3	84	2	20639461
Pubmed	Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.	EGR2 EGR3	1.73e-05	3	84	2	15173177
Pubmed	Association of common polymorphisms in TNFA, NFkB1 and NFKBIA with risk and prognosis of esophageal squamous cell carcinoma.	NFKBIA TNF	1.73e-05	3	84	2	24324738
Pubmed	CD40L and TNF both activate the classical NF-κB pathway, which is not required for the CD40L induced alternative pathway in endothelial cells.	CD40LG TNF	1.73e-05	3	84	2	29183724
Pubmed	Early growth response genes 2 and 3 induced by AP-1 and NF-κB modulate TGF-β1 transcription in NK1.1- CD4+ NKG2D+ T cells.	EGR2 EGR3	1.73e-05	3	84	2	33011290
Pubmed	The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.	EGR2 WWP2	1.73e-05	3	84	2	19651900
Pubmed	Structural Analysis of the SANT/Myb Domain of FLASH and YARP Proteins and Their Complex with the C-Terminal Fragment of NPAT by NMR Spectroscopy and Computer Simulations.	CASP8AP2 GON4L	1.73e-05	3	84	2	32722282
Pubmed	The Justy mutant mouse strain produces a spontaneous murine model of salivary gland cancer with myoepithelial and basal cell differentiation.	GON4L YY1AP1	1.73e-05	3	84	2	23608756
Pubmed	Egr2 and 3 Inhibit T-bet-Mediated IFN-γ Production in T Cells.	EGR2 EGR3	1.73e-05	3	84	2	28455436
Pubmed	Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production.	EGR2 EGR3	1.73e-05	3	84	2	27911796
Pubmed	Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.	NFKBIA TNF	1.73e-05	3	84	2	17681786
Pubmed	MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.	NFKBIA TNF	1.73e-05	3	84	2	8662753
Pubmed	Early Growth Response Genes 2 and 3 Regulate the Expression of Bcl6 and Differentiation of T Follicular Helper Cells.	EGR2 EGR3	1.73e-05	3	84	2	25979336
Pubmed	HCF-1 functions as a coactivator for the zinc finger protein Krox20.	EGR2 HCFC1	1.73e-05	3	84	2	14532282
Pubmed	A novel splicing regulator shares a nuclear import pathway with SR proteins.	RBM4B RBM4	1.73e-05	3	84	2	12628928
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	JUP HIVEP1 MAP1B BRCA2 WDR33 PHF3 RBM4 MARF1 QSER1 MGA HCFC1	1.87e-05	954	84	11	36373674
Pubmed	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	EGR2 EGR3 NFKBIA	2.32e-05	23	84	3	20379146
Pubmed	Fanconi Anemia	FANCG BRCA2 RFWD3	2.32e-05	23	84	3	20301575
Pubmed	Inhibition of phagocytosis in HIV-1-infected macrophages relies on Nef-dependent alteration of focal delivery of recycling compartments.	TNF ITGAM	3.45e-05	4	84	2	20299515
Pubmed	Tumor necrosis factor-alpha (TNF-alpha) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1alpha) on human neutrophils through defined signalling pathways.	TNF ITGAM	3.45e-05	4	84	2	18164590
Pubmed	Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity.	NFKBIA TNF	3.45e-05	4	84	2	19487661
Pubmed	The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression.	NFKBIA TNF	3.45e-05	4	84	2	11799106
Pubmed	Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma.	TNF ITGAM	3.45e-05	4	84	2	17151265
Pubmed	Overexpression of mucin genes induced by interleukin-1 beta, tumor necrosis factor-alpha, lipopolysaccharide, and neutrophil elastase is inhibited by a retinoic acid receptor alpha antagonist.	TNF MUC5AC	3.45e-05	4	84	2	12042033
Pubmed	Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein.	NFKBIA TNF	3.45e-05	4	84	2	23001849
Pubmed	Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.	CD40LG TNF	3.45e-05	4	84	2	22675201
Pubmed	An amphioxus Krox gene: insights into vertebrate hindbrain evolution.	EGR2 EGR3	3.45e-05	4	84	2	11180801
Pubmed	Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia.	CD40LG TNF	3.45e-05	4	84	2	17312171
Pubmed	Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis.	NFKBIA TNF	3.45e-05	4	84	2	11880364
Pubmed	CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.	CD40LG ITGAM	3.45e-05	4	84	2	17372166
Pubmed	EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin.	EGR2 EGR3	3.45e-05	4	84	2	20506119
Pubmed	Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.	CD40LG TNF	3.45e-05	4	84	2	10637268
Interaction	UBE2D2 interactions	RC3H2 WWP2 NFKBIA SIAH2 BFAR QSER1 HERC2 TTC3 RFWD3	6.39e-06	318	83	9	int:UBE2D2
Interaction	ASF1A interactions	CASP8AP2 HIVEP1 BRCA2 PHF3 QSER1 ZDHHC17 MGA HCFC1	8.61e-06	249	83	8	int:ASF1A
Interaction	UBE2E3 interactions	RC3H2 MAP1B WWP2 NFKBIA TTC3 RFWD3	1.76e-05	132	83	6	int:UBE2E3
Interaction	MAGEA9 interactions	RC3H2 BRCA2 CEP95 ASH1L YY1AP1 HERC2 RAPGEF2	2.41e-05	208	83	7	int:MAGEA9
Cytoband	1q22	ASH1L GON4L YY1AP1	1.61e-04	57	84	3	1q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	ASH1L GON4L YY1AP1	3.09e-04	71	84	3	chr1q22
Cytoband	11q13	RBM4B RBM4 RTN3	1.36e-03	118	84	3	11q13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HIVEP1 ZNF613 EGR2 EGR3 ZNF268 ZNF665 ZNF778 ZNF625 ZNF236	4.35e-04	718	58	9	28
GeneFamily	CD molecules\|Endogenous ligands\|Tumor necrosis factor superfamily\|Death inducing signaling complex	CD40LG TNF	1.50e-03	18	58	2	781
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	FANCG BRCA2	1.85e-03	20	58	2	548
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	URI1 MAP1B MARF1 HCFC1	2.71e-03	181	58	4	694
GeneFamily	Zinc fingers CCHC-type\|RNA binding motif containing	RBM4B RBM4	2.89e-03	25	58	2	74
GeneFamily	PHD finger proteins	BRPF3 PHF3 ASH1L	3.02e-03	90	58	3	88
Coexpression	DIRMEIER_LMP1_RESPONSE_EARLY	JUP EGR2 EGR3 NFKBIA SIAH2 TNF	4.81e-08	62	84	6	M13941
Coexpression	GSE21927_UNTREATED_VS_GMCSF_GCSF_TREATED_BONE_MARROW_UP	GMNC EGR3 EPB41L5 FAM135B TMEM200B TNS3	4.06e-05	196	84	6	M7588
Coexpression	KIM_PTEN_TARGETS_DN	RBM4 MGA	1.01e-04	5	84	2	M2277
Coexpression	GSE40274_CTRL_VS_EOS_TRANSDUCED_ACTIVATED_CD4_TCELL_DN	EGR2 ATXN7L1 NFKBIA TNF PRMT3	1.23e-04	150	84	5	M9139
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	PIKFYVE HIVEP1 MAP1B PHF3 MARF1 PRMT3 RAPGEF2 ZDHHC17	1.26e-04	466	84	8	M13522
Coexpression	KOYAMA_SEMA3B_TARGETS_DN	NFKBIA ASH1L SERTAD4 GON4L QSER1 ITGAM TNS3	1.70e-04	364	84	7	M2029
Coexpression	DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN	FRAS1 PHLDB1 SERTAD4 EPB41L5 RAPGEF2 ZDHHC17 LYST TNS3	2.14e-04	504	84	8	M2157
Coexpression	GSE13946_CTRL_VS_DSS_COLITIS_GD_TCELL_FROM_COLON_DN	BRCA2 EGR2 PRMT3 QSER1 TTC3	2.21e-04	170	84	5	M2942
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_8	FANCG NFKBIA ITGAM	2.28e-04	37	84	3	M1392
Coexpression	SHIN_B_CELL_LYMPHOMA_CLUSTER_8	FANCG NFKBIA ITGAM	2.28e-04	37	84	3	MM588
Coexpression	GENTILE_UV_RESPONSE_CLUSTER_D2	MAP1B PHF3 RAPGEF2	2.47e-04	38	84	3	M12861
Coexpression	TERAMOTO_OPN_TARGETS_CLUSTER_5	GON4L YY1AP1	2.81e-04	8	84	2	MM522
Coexpression	ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN	WDR33 ADCY1 SDK1	3.57e-04	43	84	3	M17794
Coexpression	CHASSOT_SKIN_WOUND	EGR2 EGR3	3.60e-04	9	84	2	M13038
Coexpression	GSE2706_R848_VS_R848_AND_LPS_2H_STIM_DC_DN	NEK1 EGR3 ATXN7L1 DGKE TNF	3.78e-04	191	84	5	M4715
Coexpression	GSE17974_0H_VS_0.5H_IN_VITRO_ACT_CD4_TCELL_DN	EGR2 EGR3 WDR33 ZNF778 TNF	3.87e-04	192	84	5	M4154
Coexpression	LAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM	FRAS1 MCTP1 ATXN7L1 NFKBIA GON4L PLEKHA5 NCKAP5	3.88e-04	417	84	7	M39224
Coexpression	PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN	GARIN5B RC3H2 MAP1B MARF1	3.94e-04	107	84	4	MM947
Coexpression	MEK_UP.V1_DN	EGR3 ELAPOR1 MARF1 OXSM PRMT3	4.06e-04	194	84	5	M2724
Coexpression	GSE21670_UNTREATED_VS_TGFB_IL6_TREATED_CD4_TCELL_UP	FANCG NEK1 GAS2L3 CRYBG1 PCNX1	4.06e-04	194	84	5	M7467
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	PIKFYVE NEK1 URI1 HIVEP1 MAP1B BRCA2 PHF3 PRMT3 RAPGEF2 ZDHHC17	4.07e-04	856	84	10	M4500
Coexpression	GSE9988_ANTI_TREM1_VS_ANTI_TREM1_AND_LPS_MONOCYTE_DN	HIVEP1 NFKBIA SIAH2 TNF RAPGEF2	4.25e-04	196	84	5	M5849
Coexpression	GSE13411_NAIVE_BCELL_VS_PLASMA_CELL_UP	PIKFYVE ZNF665 GON4L CRYBG1 MGA	4.25e-04	196	84	5	M3243
Coexpression	GSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_1H_CD4_TCELL_DN	EGR2 EGR3 WDR33 CD40LG TNF	4.25e-04	196	84	5	M4182
Coexpression	GSE3982_MAC_VS_EFF_MEMORY_CD4_TCELL_DN	ZNF665 TLL2 CD40LG YY1AP1 QSER1	4.25e-04	196	84	5	M5504
Coexpression	GSE46606_UNSTIM_VS_CD40L_IL2_IL5_DAY3_STIMULATED_BCELL_UP	SERTAD4 MARF1 THAP10 HERC2 TNS3	4.25e-04	196	84	5	M9867
Coexpression	GSE34156_NOD2_LIGAND_VS_TLR1_TLR2_LIGAND_24H_TREATED_MONOCYTE_DN	MAP1B WDR33 ZNF778 TTC3 TUBE1	4.25e-04	196	84	5	M8678
Coexpression	GSE9988_LOW_LPS_VS_CTRL_TREATED_MONOCYTE_UP	EGR3 NFKBIA SIAH2 TNF RAPGEF2	4.35e-04	197	84	5	M5867
Coexpression	GSE37416_0H_VS_3H_F_TULARENSIS_LVS_NEUTROPHIL_DN	BRPF3 NFKBIA OXSM TNF RAPGEF2	4.35e-04	197	84	5	M5342
Coexpression	GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_GRAN_MONO_PROGENITOR_DN	PIKFYVE RBM4 GON4L OXSM PRMT3	4.35e-04	197	84	5	M8871
Coexpression	SILIGAN_BOUND_BY_EWS_FLT1_FUSION	NEK1 WWP2 ADCY1	4.36e-04	46	84	3	M5218
Coexpression	GSE9988_ANTI_TREM1_VS_LOW_LPS_MONOCYTE_DN	HIVEP1 NFKBIA SIAH2 TNF RAPGEF2	4.45e-04	198	84	5	M5847
Coexpression	GSE15659_NAIVE_CD4_TCELL_VS_RESTING_TREG_DN	WDR33 ZNF268 ZNF665 TLL2 TNF	4.45e-04	198	84	5	M3542
Coexpression	GSE9006_HEALTHY_VS_TYPE_2_DIABETES_PBMC_AT_DX_DN	EGR2 EGR3 ASH1L CRYBG1 PCNX1	4.45e-04	198	84	5	M5782
Coexpression	GSE37534_UNTREATED_VS_GW1929_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	FRAS1 HIVEP1 NFKBIA CRYBG1 OMG	4.56e-04	199	84	5	M8978
Coexpression	GSE45365_WT_VS_IFNAR_KO_CD8A_DC_DN	AKAP4 RBM4 NFKBIA PCNX1 RAPGEF2	4.56e-04	199	84	5	M9963
Coexpression	GSE17974_0H_VS_2H_IN_VITRO_ACT_CD4_TCELL_DN	EGR2 EGR3 TNF TUBE1 LYST	4.56e-04	199	84	5	M4159
Coexpression	GSE17974_0H_VS_4H_IN_VITRO_ACT_CD4_TCELL_DN	EGR2 EGR3 TNF LYST TNS3	4.56e-04	199	84	5	M4161
Coexpression	GSE20727_H2O2_VS_ROS_INHIBITOR_TREATED_DC_DN	EGR3 ATXN7L1 BFAR PRMT3 ZDHHC17	4.56e-04	199	84	5	M9253
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_GRAN_MONO_PROGENITOR_DN	CASP8AP2 WWP2 MARF1 BFAR HERC2	4.56e-04	199	84	5	M8861
Coexpression	GSE31082_CD4_VS_CD8_SP_THYMOCYTE_UP	HIVEP1 CRYBG1 PCNX1 RAPGEF2 ZDHHC17	4.66e-04	200	84	5	M5069
Coexpression	GSE16385_ROSIGLITAZONE_IL4_VS_ROSIGLITAZONE_ALONE_STIM_MACROPHAGE_UP	JUP FRMPD3 LYST TNS3 CC2D2B	4.66e-04	200	84	5	M7986
Coexpression	GSE3982_CTRL_VS_LPS_4H_MAC_UP	WDR33 ASH1L OXSM ZDHHC17 MGA	4.66e-04	200	84	5	M5367
Coexpression	GSE42021_CD24HI_VS_CD24INT_TCONV_THYMUS_DN	ZNF613 EGR2 SLC35C1 CD40LG CRYBG1	4.66e-04	200	84	5	M9593
Coexpression	GSE19923_WT_VS_HEB_AND_E2A_KO_DP_THYMOCYTE_DN	EGR2 NFKBIA TNF LYST HCFC1	4.66e-04	200	84	5	M7269
Coexpression	GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_6H_DN	RBM4B CD40LG SIAH2 PCNX1 BFAR	4.66e-04	200	84	5	M9923
Coexpression	GSE17721_POLYIC_VS_CPG_24H_BMDC_DN	ATXN7L1 SLC35C1 PCNX1 HERC2 MGA	4.66e-04	200	84	5	M3954
Coexpression	GSE37301_COMMON_LYMPHOID_PROGENITOR_VS_CD4_TCELL_DN	PIKFYVE RTN3 PCNX1 HERC2 ZDHHC17	4.66e-04	200	84	5	M8869
Coexpression	GSE20366_CD103_POS_VS_CD103_KLRG1_DP_TREG_UP	EGR2 CEP95 PCNX1 DGKE PRMT3	4.66e-04	200	84	5	M4344
Coexpression	GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_DN	PHLDB1 ASH1L PLEKHA5 PRMT3 TTC3	4.66e-04	200	84	5	M3044
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 ATXN7L1 ASH1L PLEKHA5 NCKAP5 RAPGEF2 SDK1	7.93e-08	192	84	7	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 PHLDB1 MCTP1 MAP1B MGA HCFC1	1.15e-06	179	84	6	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	HIVEP1 PHF3 CEP95 PCNX1 TTC3	1.62e-05	167	84	5	ced6ed9b412739c6ced622523347c10295edbf53
ToppCell	COVID-19-Myeloid-MoAM5,_CCL3L1\|Myeloid / Condition, Lineage and Cell class	HIVEP1 EGR2 EGR3 NFKBIA TNF	1.66e-05	168	84	5	ea465152ea31391b63c02425beafa9a4f51f6703
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRPF3 ATXN7L1 WWP2 PCNX1 RAPGEF2	1.81e-05	171	84	5	a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRPF3 PHLDB1 PLEKHA5 QSER1 ZNF236	2.08e-05	176	84	5	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFKBIA MARF1 RTN3 DGKE TUBE1	2.51e-05	183	84	5	6a15ffb56381b724ef4d574e7b2835e00e1a0092
ToppCell	NS-critical-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEP120 BRCA2 SERTAD4 TMEM200B RFWD3	3.00e-05	190	84	5	7be0f2ff86ca8500a43e0d44e5e292530f9ba0bb
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 HIVEP1 PHF3 PLEKHA5 SDK1	3.16e-05	192	84	5	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	FRAS1 HIVEP1 PHF3 PLEKHA5 SDK1	3.23e-05	193	84	5	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	BL\|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MCTP1 NFKBIA PCNX1 ITGAM LYST	3.57e-05	197	84	5	1acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCell	facs-Diaphragm-Limb_Muscle-18m-Myeloid-nan\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAS2L3 SLC35C1 TNF ITGAM	1.68e-04	146	84	4	69cbe8d4772f8e46a5e1a1cdca0e370308a97b4f
ToppCell	ILEUM-non-inflamed-(3)_MNP-(3)_Inf._Macrophages\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NFKBIA TNF RAPGEF2 TMEM200B	1.91e-04	151	84	4	88f7498f29e43441e0982f9f97ea563edf2835a4
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SERTAD4 TNF ITGAM FAM135B	1.91e-04	151	84	4	0cc2f4aec3dae4603fa831f22c40f897e68b34e2
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SERTAD4 TNF ITGAM FAM135B	1.91e-04	151	84	4	b545823113a3450c5f841f7de48bf0937593544f
ToppCell	Club_cells-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	ESPN JUP ELAPOR1 ADCY1	2.01e-04	153	84	4	77030b0e033f3635b1bbe7552a28c074ea7bb106
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ESPN FRAS1 SERTAD4 ADCY1	2.16e-04	156	84	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ESPN FRAS1 SERTAD4 ADCY1	2.16e-04	156	84	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GMNC CEP120 BRCA2 TMEM200B	2.22e-04	157	84	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GMNC ELAPOR1 MUC5AC SDK1	2.33e-04	159	84	4	60b1f4dce2ce0911160fda17f137c064da31e2eb
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-macrophage\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 GAS2L3 TNF ITGAM	2.50e-04	162	84	4	db1e09324e9fdd5e571600cff4f2b1c0cb3c179d
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 GAS2L3 TNF ITGAM	2.50e-04	162	84	4	9734943c8b7c04e568792253b7352672a3a5cc58
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Myeloid\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 GAS2L3 TNF ITGAM	2.50e-04	162	84	4	48d7bee271f74b5d06c03c6ae06a662d765a6de3
ToppCell	facs-MAT-Fat-3m-Myeloid-nan\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 GAS2L3 TNF ITGAM	2.62e-04	164	84	4	1250876abd7311f86730e5b9c03c3610cc2ff6d3
ToppCell	facs-MAT-Fat-3m-Myeloid\|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 GAS2L3 TNF ITGAM	2.62e-04	164	84	4	fa0d77b648cde5e42b9394e877168c80de238bde
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 EGR3 ITGAM LYST	2.62e-04	164	84	4	8e6dbddacd56a07769163813e3ebfad13302bb62
ToppCell	Adult-Epithelial-lung_goblet_cell-D122\|Adult / Lineage, Cell type, age group and donor	GMNC ELAPOR1 MUC5AC SDK1	2.80e-04	167	84	4	6efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCell	3'_v3-Lung-Lymphocytic_Invariant-Inducer-like\|Lung / Manually curated celltypes from each tissue	ESPN NFKBIA ELAPOR1 TNF	2.87e-04	168	84	4	b9bde6f542d730682d34a80e1f7f1609e5c699c7
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CASP8AP2 SLC35C1 ITGAM RFWD3	2.87e-04	168	84	4	27cdf5cfa1d906868cfd60fdfab3cd51f3b3602f
ToppCell	5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CEP120 PCNX1 DGKE MGA	2.93e-04	169	84	4	8caf7996796a2e2716e3855de855c903d6126bf2
ToppCell	Fetal_29-31_weeks-Epithelial-basal_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GMNC FRAS1 ELAPOR1 SDK1	2.93e-04	169	84	4	c3ee781735a9288ce1822b230d39bb91c1415589
ToppCell	Frontal_cortex-Macroglia-POLYDENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	PHLDB1 NCKAP5 MUCL3 TNS3	2.93e-04	169	84	4	50cc0f5a022b95986949db63208a627cef9f4a69
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF268 SERTAD4 MARF1 ZNF625	3.07e-04	171	84	4	6a2f88c2a62cb2f69797804e24eb1137a3e148de
ToppCell	356C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNF268 SERTAD4 MARF1 ZNF625	3.07e-04	171	84	4	9be3554626408bb897d1f1c43b3ab4a92651f2e2
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGR3 EPB41L5 MUC5AC SDK1	3.07e-04	171	84	4	eddc5e05003382603ee49f74b9e2242a43021096
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PCNX1 OXSM TNF RAPGEF2	3.14e-04	172	84	4	a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCell	droplet-Fat-Scat-21m-Endothelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JUP BRCA2 EGR3 RAPGEF2	3.21e-04	173	84	4	f13124b4cf2ac1dc2895f90f5487d6ac681b0ba4
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SLC35C1 ELAPOR1 MUC5AC ADCY1	3.21e-04	173	84	4	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	COVID-19-Myeloid-MoAM5,_CCL3L1\|COVID-19 / Condition, Lineage and Cell class	EGR2 EGR3 NFKBIA TNF	3.21e-04	173	84	4	502f888b7684ed39f5c577eedcacf673ae81d39e
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CEP120 ATG2B ELAPOR1 HCFC1	3.28e-04	174	84	4	a1f745962a104c6f4b86b7e482da8755384c773a
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MCTP1 SLC35C1 DGKE ADCY1	3.28e-04	174	84	4	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	Adult-Epithelial-lung_goblet_cell-D231\|Adult / Lineage, Cell type, age group and donor	FRAS1 ELAPOR1 MUC5AC SDK1	3.28e-04	174	84	4	7d2f802f493f19a068e097b2909a9000e2160266
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_E\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CEP120 ATG2B ELAPOR1 HCFC1	3.35e-04	175	84	4	78a86cac3e6c0d115c997d1c29ee0e24af54551f
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	JUP GON4L FRMPD3 TNS3	3.42e-04	176	84	4	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGR3 EPB41L5 MUC5AC SDK1	3.50e-04	177	84	4	a235ff4f37a7622216526191efc4832fb8ed6957
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_E\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ESPN PHLDB1 CEP95 TUBE1	3.50e-04	177	84	4	946803293a7955116c80f403e99e4093e798ca3f
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|343B / Donor, Lineage, Cell class and subclass (all cells)	FANCG CEP120 CD40LG OPLAH	3.57e-04	178	84	4	5289ac61637224ae70ffbc2d164d73116f10af40
ToppCell	T_cells-TFH-like_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MCTP1 EGR3 ELAPOR1 SDK1	3.57e-04	178	84	4	e2ae43e5ec31de6197f2cbd6089f944adbf0a163
ToppCell	Club_cells-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	JUP ELAPOR1 MUC5AC SDK1	3.57e-04	178	84	4	be64d4be23fb96a4cdd7980c58880fdfe817747f
ToppCell	ASK452-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	FANCG SLC35C1 ELAPOR1 OPLAH	3.65e-04	179	84	4	c3cf49c069e66db16d2fce1de4c52a4c4fe7e832
ToppCell	NS-critical-d_0-4-Epithelial-Ionocyte\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ESPN ZNF613 MAP1B NCKAP5	3.80e-04	181	84	4	cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	3.80e-04	181	84	4	aa233b652921848af2257cc3687a7a09c3acfb67
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CASP8AP2 EGR2 EGR3 HCFC1	3.88e-04	182	84	4	4a85429d365c4b2d73fc921f261b4b7635ac40bd
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CASP8AP2 EGR2 EGR3 HCFC1	3.88e-04	182	84	4	53213af34af3337f5edc734d3b7b79e4349eac0d
ToppCell	droplet-Marrow-nan-3m-Hematologic-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 PLEKHA5 TTC3 LYST	3.88e-04	182	84	4	e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCell	droplet-Marrow-nan-3m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CASP8AP2 PLEKHA5 TTC3 LYST	3.88e-04	182	84	4	1710eab3037a87609d21838be2d2d29c3bc36651
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_macrophage-lung_macrophage-Interstitial_macrophage_perivascular-Interstitial_macrophage_perivascular_L.1.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CASP8AP2 EGR2 EGR3 HCFC1	3.88e-04	182	84	4	7909089ed6325c44edd6f9b7e8b1d542398222ea
ToppCell	wk_15-18-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	NFKBIA CD40LG ELAPOR1 TNF	3.88e-04	182	84	4	6bd48c5d60a259719f65cacee4b8135247e78fa9
ToppCell	facs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NFKBIA MARF1 DGKE TUBE1	4.05e-04	184	84	4	b80d3f2b76927842a54bc89a87cd70469a6d825a
ToppCell	droplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESPN ELAPOR1 FRMPD3 ADCY1	4.05e-04	184	84	4	e0e5a553fb8c0947679634396d20c2ca8455b932
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	CRYBG1 PLEKHA5 NCKAP5 SDK1	4.05e-04	184	84	4	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	343B-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FANCG URI1 CEP120 OPLAH	4.05e-04	184	84	4	2c2125b8030af83f7a6d59a7102d4de8e0ac1988
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EGR2 EGR3 CD40LG TNF	4.05e-04	184	84	4	780d67f04fc795f614e077d8a5cf368542f6d99d
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	CASP8AP2 GON4L MGA RHNO1	4.05e-04	184	84	4	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	droplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESPN ELAPOR1 FRMPD3 ADCY1	4.05e-04	184	84	4	c3b848e1438a84b3fac8a4e40f3db478cc84d970
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCTP1 MAP1B NFKBIA TNF	4.05e-04	184	84	4	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-lung_neuroendocrine_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESPN ELAPOR1 FRMPD3 ADCY1	4.13e-04	185	84	4	30263c558ee331e0879abcf8b4c2427ff05f9fe7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 RTN3 CRYBG1 SDK1	4.13e-04	185	84	4	d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCell	HSPCs-Eo/Baso_prog.\|HSPCs / Lineage and Cell class	EGR2 NFKBIA ELAPOR1 TNF	4.13e-04	185	84	4	1ae29c0077bfc57e8896e59a21f20af43e7ff5b7
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP1 MAP1B NFKBIA ASH1L	4.13e-04	185	84	4	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CEP95 ELAPOR1 ITGAM MGA	4.13e-04	185	84	4	7925519b855f76444a0b57382ce35d89457b0b14
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Neuroendocrine\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESPN ELAPOR1 FRMPD3 ADCY1	4.13e-04	185	84	4	1b000ca11970db8f347eb97ff44605d562aea70a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCTP1 MAP1B TTC3 ADCY1	4.22e-04	186	84	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	CRYBG1 PLEKHA5 NCKAP5 SDK1	4.22e-04	186	84	4	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA5 DGKE TTC3 TNS3	4.22e-04	186	84	4	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	Control-Epithelial-Club\|World / Disease state, Lineage and Cell class	JUP ELAPOR1 EPB41L5 NCKAP5	4.22e-04	186	84	4	9798428691408e17ff2af2fe2d1b345f074d67e4
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA5 DGKE TTC3 TNS3	4.22e-04	186	84	4	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	normal_Pleural_Fluid-Myeloid_cells-Alveolar_Mac\|Myeloid_cells / Location, Cell class and cell subclass	BRPF3 PHLDB1 YY1AP1 CC2D2B	4.22e-04	186	84	4	701eea0016d69f0f9d29b613948f91239096e6c7
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PLEKHA5 DGKE TTC3 TNS3	4.22e-04	186	84	4	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PLEKHA5 NCKAP5 SDK1 FAM135B	4.22e-04	186	84	4	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	COVID-19-kidney-tDL\|kidney / Disease (COVID-19 only), tissue and cell type	GAS2L3 PLEKHA5 NCKAP5 SDK1	4.30e-04	187	84	4	d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.4.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EGR2 NFKBIA TNF ITGAM	4.30e-04	187	84	4	d56664da336a580e9da2ea52622b5ce36fdafb1c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRCA2 GAS2L3 ELAPOR1 RFWD3	4.30e-04	187	84	4	9351fa87b69a951af85b10bf91fe9b1cce8c0517
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	4.30e-04	187	84	4	e3095455d2f255854f339f6b05fa87852af0700f
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Cytotoxic_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EGR2 NFKBIA TNF LYST	4.39e-04	188	84	4	c80956649b10b7dd7540394a00fc2a0619b27e80
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESPN FRMPD3 TTC3 ADCY1	4.39e-04	188	84	4	1efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCell	343B-Lymphocytic-ILC-ILC-1\|343B / Donor, Lineage, Cell class and subclass (all cells)	EGR3 CD40LG PCNX1 ZNF625	4.39e-04	188	84	4	8f6b45ad82bde65e044d17f0edbc3db90d457915
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	CRYBG1 PLEKHA5 NCKAP5 SDK1	4.39e-04	188	84	4	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	ILEUM-inflamed-(1)_Cytotoxic_CD8_Trm\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	EGR2 NFKBIA TNF LYST	4.39e-04	188	84	4	d26894d1066a70e4b32ae41fff1c4718f2591ba9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	4.39e-04	188	84	4	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	control-immature_Neutrophil\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLC35C1 TNF QSER1 TNS3	4.48e-04	189	84	4	bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCell	cellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HIVEP1 BRCA2 EGR2 GON4L	4.48e-04	189	84	4	bccb3481ffed597c845fe860da658505316105b5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	4.48e-04	189	84	4	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B FRMPD3 TTC3 ADCY1	4.48e-04	189	84	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	GAS2L3 PLEKHA5 NCKAP5 SDK1	4.48e-04	189	84	4	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	EGR2 EGR3 NFKBIA RAPGEF2	4.57e-04	190	84	4	4d401b73c0e7eb38e95d0851a128bf12bb0d3a9f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	4.57e-04	190	84	4	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	NS-moderate-d_16-33-Epithelial-FOXN4+\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CEP120 BRCA2 SERTAD4 TMEM200B	4.57e-04	190	84	4	250ca4a605c1cccd77d23383e4fe6f91cf3609ba
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRAS1 MCTP1 CRYBG1 SDK1	4.57e-04	190	84	4	b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCell	IPF-Epithelial-Goblet\|World / Disease state, Lineage and Cell class	JUP ELAPOR1 MUC5AC SDK1	4.57e-04	190	84	4	c29dabf0826663b9d6df51a7af9b76592090e44c
Drug	4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline	FANCG BRCA2 NFKBIA TNF	4.39e-06	30	84	4	ctd:C471109
Drug	Phenformin hydrochloride [834-28-6]; Down 200; 16.6uM; PC3; HT_HG-U133A	MAP1B PHF3 RBM4 ASH1L PCNX1 RAPGEF2 LYST	6.88e-06	191	84	7	4283_DN
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	MAP1B PHF3 RBM4 GON4L PCNX1 ZDHHC17 LYST	8.70e-06	198	84	7	3294_DN
Drug	dimemorfan	NFKBIA TNF ITGAM	3.17e-05	17	84	3	ctd:C012621
Drug	RV09 compound	NFKBIA TNF	4.03e-05	3	84	2	ctd:C531164
Drug	benzcoprine	NFKBIA TNF	4.03e-05	3	84	2	ctd:C020710
Drug	plaunotol	TNF ITGAM	4.03e-05	3	84	2	ctd:C047686
Drug	Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; PC3; HT_HG-U133A	PHLDB1 SLC35C1 PCNX1 DGKE RAPGEF2 MUC5AC	5.31e-05	179	84	6	4619_UP
Drug	LY 294002; Up 200; 10uM; PC3; HT_HG-U133A	MCTP1 ATG2B MARF1 PCNX1 DGKE LYST	6.57e-05	186	84	6	4463_UP
Drug	Doxorubicin hydrochloride [25316-40-9]; Down 200; 6.8uM; MCF7; HT_HG-U133A	EGR3 PHF3 NFKBIA OXSM RAPGEF2 MGA	6.97e-05	188	84	6	3291_DN
Drug	retinoic acid; Down 200; 1uM; MCF7; HT_HG-U133A	PHLDB1 EGR3 EPB41L5 PCNX1 ADCY1 HCFC1	7.18e-05	189	84	6	5208_DN
Drug	loxoribine	CASP8AP2 NFKBIA TNF LYST	7.18e-05	60	84	4	CID000060737
Drug	Cinchonine [118-10-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A	FRAS1 MAP1B WDR33 ZNF665 PCNX1 LYST	7.61e-05	191	84	6	2789_DN
Drug	Pramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; PC3; HT_HG-U133A	PHF3 RBM4 EPB41L5 GON4L PCNX1 HCFC1	7.61e-05	191	84	6	3811_DN
Drug	BN 50739	NFKBIA TNF	8.03e-05	4	84	2	ctd:C064509
Drug	yu ping feng san	NFKBIA TNF	8.03e-05	4	84	2	ctd:C506362
Drug	praeruptorin A	NFKBIA TNF	8.03e-05	4	84	2	ctd:C441070
Drug	3-methylcatechol	NFKBIA TNF	8.03e-05	4	84	2	ctd:C031136
Drug	Cyproterone acetate [427-51-0]; Down 200; 9.6uM; PC3; HT_HG-U133A	ATXN7L1 PHF3 RBM4 GON4L PCNX1 RFWD3	8.29e-05	194	84	6	4470_DN
Drug	Benfotiamine [22457-89-2]; Down 200; 8.6uM; PC3; HT_HG-U133A	RC3H2 MAP1B PHF3 PCNX1 RAPGEF2 ZDHHC17	8.29e-05	194	84	6	4312_DN
Drug	ST021200; Down 200; 10uM; PC3; HT_HG-U133A	BRCA2 WDR33 ZNF665 ATG2B LYST ADCY1	8.53e-05	195	84	6	7493_DN
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT_HG-U133A	NEK1 PHF3 DGKE RAPGEF2 ZDHHC17 HCFC1	8.53e-05	195	84	6	3835_DN
Drug	Flufenamic acid [530-78-9]; Down 200; 14.2uM; HL60; HG-U133A	URI1 ZNF268 RBM4 PCNX1 RAPGEF2 RFWD3	8.53e-05	195	84	6	1420_DN
Drug	Nefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; HL60; HT_HG-U133A	RC3H2 MAP1B ASH1L PCNX1 HCFC1 KIAA0753	8.77e-05	196	84	6	2355_UP
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	NEK1 MCTP1 DGKE RAPGEF2 LYST ADCY1	9.02e-05	197	84	6	4974_DN
Drug	Antigen-Antibody Complex	EGR2 EGR3 TNF	9.27e-05	24	84	3	ctd:D000936
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	EGR3 ATXN7L1 ELAPOR1 ZNF236 MUC5AC OMG	9.28e-05	198	84	6	4422_UP
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; HL60; HT_HG-U133A	NEK1 RC3H2 PHF3 GON4L PCNX1 RFWD3	9.28e-05	198	84	6	2362_DN
Drug	Norethindrone [68-22-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	FRAS1 PHLDB1 EGR3 SLC35C1 PCNX1 HCFC1	9.54e-05	199	84	6	7414_UP
Drug	3-nitropropionic acid; Down 200; 10uM; PC3; HT_HG-U133A	NEK1 HIVEP1 ATXN7L1 SLC35C1 ZNF236 MUC5AC	9.81e-05	200	84	6	6407_DN
Disease	Fanconi Anemia	FANCG BRCA2 TNF RFWD3	6.07e-07	25	80	4	C0015625
Disease	Fanconi anemia (is_implicated_in)	FANCG BRCA2 RFWD3	2.27e-06	10	80	3	DOID:13636 (is_implicated_in)
Disease	salivary gland cancer (implicated_via_orthology)	GON4L YY1AP1	7.26e-06	2	80	2	DOID:8850 (implicated_via_orthology)
Disease	corneal ulcer (is_marker_for)	TNF MUC5AC	2.17e-05	3	80	2	DOID:8463 (is_marker_for)
Disease	thrombosis (is_marker_for)	CD40LG ITGAM	4.34e-05	4	80	2	DOID:0060903 (is_marker_for)
Disease	gastritis (implicated_via_orthology)	NFKBIA TNF	7.22e-05	5	80	2	DOID:4029 (implicated_via_orthology)
Disease	Behcet's disease (is_marker_for)	CD40LG TNF ITGAM	9.87e-05	33	80	3	DOID:13241 (is_marker_for)
Disease	familial hyperlipidemia (is_marker_for)	CD40LG ITGAM	1.08e-04	6	80	2	DOID:1168 (is_marker_for)
Disease	toxic shock syndrome (biomarker_via_orthology)	NFKBIA TNF	1.08e-04	6	80	2	DOID:14115 (biomarker_via_orthology)
Disease	asphyxiating thoracic dystrophy (is_implicated_in)	NEK1 KIAA0753	1.51e-04	7	80	2	DOID:0050592 (is_implicated_in)
Disease	encephalitis (biomarker_via_orthology)	NFKBIA TNF	2.58e-04	9	80	2	DOID:9588 (biomarker_via_orthology)
Disease	prostate cancer (is_implicated_in)	JUP BRCA2 NFKBIA TNF	2.94e-04	117	80	4	DOID:10283 (is_implicated_in)
Disease	Asthma, Occupational	TNF HERC2	3.22e-04	10	80	2	C0264423
Disease	Hemolytic-Uremic Syndrome	DGKE TNF	3.93e-04	11	80	2	C0019061
Disease	diabetic angiopathy (is_marker_for)	CD40LG ITGAM	4.71e-04	12	80	2	DOID:11713 (is_marker_for)
Disease	Kawasaki disease (is_implicated_in)	CD40LG TNF	4.71e-04	12	80	2	DOID:13378 (is_implicated_in)
Disease	Short Rib-Polydactyly Syndrome	NEK1 CEP120	5.55e-04	13	80	2	C0036996
Disease	bronchopulmonary dysplasia (is_implicated_in)	NFKBIA TNF	5.55e-04	13	80	2	DOID:11650 (is_implicated_in)
Disease	rhinitis (biomarker_via_orthology)	TNF MUC5AC	5.55e-04	13	80	2	DOID:4483 (biomarker_via_orthology)
Disease	multiple myeloma (is_implicated_in)	NFKBIA CD40LG TNF	5.59e-04	59	80	3	DOID:9538 (is_implicated_in)
Disease	Fanconi anemia	FANCG BRCA2	6.47e-04	14	80	2	cv:C0015625
Disease	Saldino-Noonan Syndrome	NEK1 CEP120	6.47e-04	14	80	2	C0036069
Disease	sickle cell anemia (is_marker_for)	CD40LG TNF	6.47e-04	14	80	2	DOID:10923 (is_marker_for)
Disease	Majewski Syndrome	NEK1 CEP120	6.47e-04	14	80	2	C0024507
Disease	cystic fibrosis (is_marker_for)	CD40LG TNF MUC5AC	6.47e-04	62	80	3	DOID:1485 (is_marker_for)
Disease	endometriosis (biomarker_via_orthology)	NFKBIA TNF	8.50e-04	16	80	2	DOID:289 (biomarker_via_orthology)
Disease	Malignant Glioma	PHLDB1 BRCA2 TNF	9.22e-04	70	80	3	C0555198
Disease	mixed gliomas	PHLDB1 BRCA2 TNF	9.22e-04	70	80	3	C0259783
Disease	lupus nephritis (is_marker_for)	CD40LG TNF	9.61e-04	17	80	2	DOID:0080162 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	CD40LG TNF	9.61e-04	17	80	2	DOID:8677 (biomarker_via_orthology)
Disease	otitis media (biomarker_via_orthology)	TNF MUC5AC	9.61e-04	17	80	2	DOID:10754 (biomarker_via_orthology)
Disease	lupus nephritis (is_implicated_in)	CD40LG ITGAM	1.08e-03	18	80	2	DOID:0080162 (is_implicated_in)
Disease	alcoholic hepatitis (biomarker_via_orthology)	NFKBIA TNF	1.08e-03	18	80	2	DOID:12351 (biomarker_via_orthology)
Disease	Bone marrow hypocellularity	FANCG BRCA2	1.08e-03	18	80	2	C1855710
Disease	pulse pressure measurement	RC3H2 JUP BRPF3 CEP120 MAP1B WWP2 NFKBIA TNF HCFC1 TNS3 KIAA0753	1.30e-03	1392	80	11	EFO_0005763
Disease	Ewing sarcoma	EGR2 FAM135B	1.34e-03	20	80	2	EFO_0000174
Disease	hair colour measurement	FRAS1 ATXN7L1 ZNF778 PCNX1 QSER1 HERC2 LYST	1.41e-03	615	80	7	EFO_0007822
Disease	Glioma	PHLDB1 BRCA2 TNF	1.73e-03	87	80	3	C0017638
Disease	Bipolar Disorder	BRCA2 EGR2 EGR3 TLL2 TNF ITGAM	1.90e-03	477	80	6	C0005586
Disease	unipolar depression, neuroticism measurement	PHF3 TLL2	1.93e-03	24	80	2	EFO_0003761, EFO_0007660
Disease	Sjogren's syndrome (is_marker_for)	CD40LG MUC5AC	1.93e-03	24	80	2	DOID:12894 (is_marker_for)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	EGR2 NFKBIA TNF	2.09e-03	93	80	3	DOID:3525 (biomarker_via_orthology)
Disease	pre-eclampsia (is_implicated_in)	TNF ITGAM	2.09e-03	25	80	2	DOID:10591 (is_implicated_in)
Disease	Pancytopenia	FANCG BRCA2	2.26e-03	26	80	2	C0030312
Disease	Endogenous Hyperinsulinism	TNF ITGAM	2.26e-03	26	80	2	C1257963
Disease	Exogenous Hyperinsulinism	TNF ITGAM	2.26e-03	26	80	2	C1257964
Disease	Compensatory Hyperinsulinemia	TNF ITGAM	2.26e-03	26	80	2	C1257965
Disease	Pancreatic Neoplasm	BRCA2 NFKBIA TNF	2.57e-03	100	80	3	C0030297
Disease	corpus callosum central volume measurement	GMNC FANCG	2.62e-03	28	80	2	EFO_0010296
Disease	Hyperinsulinism	TNF ITGAM	2.62e-03	28	80	2	C0020459
Disease	obesity (is_marker_for)	CD40LG TNF ITGAM	2.64e-03	101	80	3	DOID:9970 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSSGKTCHSPSERSH	C2orf16	1871	Q68DN1
LTSSCSPHHIKRSVV	ASH1L	1786	Q9NR48
THSSAKPCGQQSIHL	CD40LG	211	P29965
QHALSPSTSTCKHKV	AKAP4	126	Q5JQC9
ESCSKHASGTSFHLP	BRPF3	101	Q9ULD4
TSHLPTSVEKHCTNG	CASP8AP2	211	Q9UKL3
HTVYKTNTASGSHPC	CC2D2B	926	Q6DHV5
FHSKEETGSHSPVCL	ATG2B	631	Q96BY7
CLSGHHSASSTSKPF	ATXN7L1	151	Q9ULK2
HKPISLGCSHTVCKT	RC3H2	26	Q9HBD1
TSTKLHVGNISPTCT	RBM4	76	Q9BWF3
CSVIKHHQRPSGTQS	QSER1	186	Q2KHR3
VLSCSPSSQGQHKHK	RFWD3	421	Q6PCD5
TTHIRTHTGEKPFAC	EGR2	386	P11161
PNHAVSTACTTGAHA	OXSM	201	Q9NWU1
PCETHETGTTHTATT	HCFC1	1321	P51610
PCETHETGTTHTATT	HCFC1	1421	P51610
LPSHDAQHKALSTCG	OR52D1	231	Q9H346
SGVHTHSEPIFCTTS	C22orf46	141	C9J442
TSNETCSGKIHTPSL	FRAS1	1091	Q86XX4
CSGKIHTPSLHVNGS	FRAS1	1096	Q86XX4
AHLCHQKSSSLPGTA	MCTP1	191	Q6DN14
HVCVSASKHSPTEDE	MAP1B	961	P46821
IHIEPGTNDSQHSKC	NEK1	961	Q96PY6
KPSEHSCITGSHTDQ	MGA	2046	Q8IWI9
LCSSPTSHKGSLQEV	HERC2	411	O95714
GTCHSCPTNTILKAH	ELAPOR1	616	Q6UXG2
DSCSSSHSSIKGQHP	ESPN	381	B1AK53
VSGTKPHSAIFCHDE	PCNX1	586	Q96RV3
SSQSIPACKHHTLVG	PCNX1	2196	Q96RV3
SCTTPHLHSILKATN	NFKBIA	166	P25963
SKTTHSQPVTRDCHP	MUC5AC	3941	P98088
KTTHSQPVTSDCHPL	MUC5AC	4616	P98088
SPLHCGTQSQTKHIL	FANCG	336	O15287
ASTKLHVGNISPTCT	RBM4B	76	Q9BQ04
IHSGANTCVPSVSSK	JUP	26	P14923
ASVKHQEHSTTACPA	PIKFYVE	951	Q9Y2I7
TSPLTHNVSGTAKAC	SLC35C1	291	Q96A29
CVSGLTQPKTDHAHC	ADCY1	356	Q08828
THIPAAGDSKSIITC	EPB41L5	31	Q9HCM4
KSTGPQISVSEFSCH	BFAR	21	Q9NZS9
HPISLSSSKCHDSVV	BRCA2	1256	P51587
PCGIKHIDCHTTSIS	PRMT3	416	O60678
SGQKIAVPATSHHFC	CEP120	441	Q8N960
HQTHPSCGTKGSAIQ	FRMPD3	366	Q5JV73
VSHLAAHSNSSSKCP	GAS2L3	486	Q86XJ1
TTHIRTHTGEKPFAC	EGR3	321	Q06889
FSTHVSIDCSPHKTV	GON4L	766	Q3T8J9
SHCSPAVNSTGEHTE	CEP95	286	Q96GE4
NKPIISLTFSCDGHH	LYST	3751	Q99698
VHKLHQFPSLQGCTS	MARF1	206	Q9Y4F3
HSHCTAELAAKSGPQ	CRYBG1	606	Q9Y4K1
AQGPCTVTITHKTHA	DGKE	526	P52429
KAGTVCPTVTHSVHS	FAM135B	981	Q49AJ0
IKGTTATLHCGATHD	SDK1	586	Q7Z5N4
HCNTTRHSKPTDKPT	MUCL3	86	Q3MIW9
TSTHQKTPVCSIDGS	RTN3	381	O95197
PKHSCASTQLPITHT	RHNO1	26	Q9BSD3
VTDSHTPCHKDVASS	URI1	261	O94763
ITVQPSGSCIEHSKS	TMEM200B	246	Q69YZ2
STSLSPHCNVKTHSF	GMNC	296	A6NCL1
CRPHGSKLTHSVSDS	NCKAP5	496	O14513
HKLHGPCLIIDSNST	OPLAH	686	O14841
ATTGCSLTLHHTEKP	SIAH2	141	O43255
SGALKSTSCSINHPI	ITGAM	856	P11215
QCSHQPSKVEISSSG	KIAA0753	156	Q2KHM9
DFHPPLSSCSHKTIS	SERTAD4	86	Q9NUC0
HLGPFTCHKSSQNSL	TNS3	506	Q68CZ2
KAHVIGTPCSTQISS	OMG	246	P23515
SSLTTHQTIHTGEKP	ZNF665	331	Q9H7R5
PQVTHVSSSHSGCSI	RAPGEF2	36	Q9Y4G8
CHSNALPSHVKISVS	WWP2	506	O00308
CGKASPVSSSLTQHV	ZNF778	286	Q96MU6
ILSAHQRTHTGEKPC	ZNF268	906	Q14587
KTSLCSVPPVGHSHS	TUBE1	381	Q9UJT0
CAHKISSVEGTLASP	TLL2	776	Q9Y6L7
LGISVKSHCSTGDAH	TTC3	1411	P53804
TGHVSHSSQKQCHKP	PHF3	616	Q92576
KTHIESSGHGVDTCL	PHLDB1	1236	Q86UU1
KVTTTSIESPFNHGC	ZDHHC17	576	Q8IUH5
EDFSTHVSIDCSPHK	YY1AP1	241	Q9H869
TCLISHQRFHTGKTP	ZNF613	441	Q6PF04
LTLHKCTHSGEDPTC	ZNF236	81	Q9UL36
KIHERTHTGEKPCSS	ZNF625	281	Q96I27
LGHILCSGSNDHTSK	WDR33	386	Q9C0J8
SVPTHCEEGPVHKST	THAP10	166	Q9P2Z0
SICSVTPSTHDKTLG	PLEKHA5	471	Q9HAU0
GTDHCVTSATLPTKL	HIVEP1	1591	P15822
KGQGCPSTHVLLTHT	TNF	141	P01375
TGQGHVVESPSHCVS	GARIN5B	306	Q8N5Q1