Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF35 ZNF442 HEY2 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ELF5 PRMT5 ZNF83	1.82e-07	1459	23	11	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF35 ZNF442 HEY2 ZNF14 ZNF93 ZNF251 ZFHX3 ELF5 ZNF83	1.42e-05	1412	23	9	GO:0000981
GeneOntologyMolecularFunction	TAP complex binding	HLA-H HLA-A	4.55e-05	9	23	2	GO:0062061
GeneOntologyMolecularFunction	CD8 receptor binding	HLA-H HLA-A	4.55e-05	9	23	2	GO:0042610
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HEY2 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 PRMT5 ZNF83	4.68e-05	1244	23	8	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HEY2 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 PRMT5 ZNF83	5.46e-05	1271	23	8	GO:0000987
GeneOntologyMolecularFunction	TAP1 binding	HLA-H HLA-A	5.68e-05	10	23	2	GO:0046978
GeneOntologyMolecularFunction	TAP2 binding	HLA-H HLA-A	5.68e-05	10	23	2	GO:0046979
GeneOntologyMolecularFunction	TAP binding	HLA-H HLA-A	5.68e-05	10	23	2	GO:0046977
GeneOntologyMolecularFunction	beta-2-microglobulin binding	HLA-H HLA-A	8.32e-05	12	23	2	GO:0030881
GeneOntologyMolecularFunction	natural killer cell lectin-like receptor binding	HLA-H HLA-A	1.71e-04	17	23	2	GO:0046703
GeneOntologyMolecularFunction	T cell receptor binding	HLA-H HLA-A	2.38e-04	20	23	2	GO:0042608
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	HEY2 ZNF14 ZNF93 ZFHX3	4.51e-04	320	23	4	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	HEY2 ZNF14 ZNF93 ZFHX3	4.83e-04	326	23	4	GO:0001217
GeneOntologyMolecularFunction	MHC class I protein binding	HLA-H HLA-A	6.16e-04	32	23	2	GO:0042288
GeneOntologyMolecularFunction	14-3-3 protein binding	HLA-H HLA-A	1.06e-03	42	23	2	GO:0071889
GeneOntologyMolecularFunction	peptide antigen binding	HLA-H HLA-A	1.44e-03	49	23	2	GO:0042605
GeneOntologyMolecularFunction	protein dimerization activity	HLA-H HLA-A HEY2 DPP4 PRMT5 THRSP	1.98e-03	1205	23	6	GO:0046983
GeneOntologyMolecularFunction	MHC protein binding	HLA-H HLA-A	2.02e-03	58	23	2	GO:0042287
GeneOntologyMolecularFunction	peptide binding	HLA-H HLA-A DPP4	5.60e-03	318	23	3	GO:0042277
GeneOntologyBiologicalProcess	T cell mediated immunity	HLA-H HLA-A MYO1G DPP4	2.96e-05	163	23	4	GO:0002456
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	HLA-H HLA-A	3.32e-05	8	23	2	GO:0002485
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA-H HLA-A	1.41e-04	16	23	2	GO:0002486
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway	HLA-H HLA-A	1.60e-04	17	23	2	GO:0002484
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA-H HLA-A	1.60e-04	17	23	2	GO:0002476
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class Ib	HLA-H HLA-A	1.80e-04	18	23	2	GO:0002428
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen via MHC class I	HLA-H HLA-A	1.80e-04	18	23	2	GO:0042590
GeneOntologyBiologicalProcess	regulation of T cell mediated immunity	HLA-H HLA-A DPP4	2.48e-04	111	23	3	GO:0002709
GeneOntologyBiologicalProcess	negative regulation of gene expression via chromosomal CpG island methylation	ZNF93 PRMT5	2.97e-04	23	23	2	GO:0044027
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I	HLA-H HLA-A	2.97e-04	23	23	2	GO:0019885
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen	HLA-H HLA-A	3.51e-04	25	23	2	GO:0002483
GeneOntologyBiologicalProcess	antigen processing and presentation via MHC class Ib	HLA-H HLA-A	3.51e-04	25	23	2	GO:0002475
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous antigen	HLA-H HLA-A	5.78e-04	32	23	2	GO:0019883
GeneOntologyBiologicalProcess	positive regulation of lymphocyte mediated immunity	HLA-H HLA-A DPP4	6.00e-04	150	23	3	GO:0002708
GeneOntologyBiologicalProcess	positive regulation of leukocyte mediated immunity	HLA-H HLA-A DPP4	9.38e-04	175	23	3	GO:0002705
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class I	HLA-H HLA-A	9.50e-04	41	23	2	GO:0002474
GeneOntologyBiologicalProcess	positive regulation of T cell mediated cytotoxicity	HLA-H HLA-A	9.97e-04	42	23	2	GO:0001916
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen	HLA-H HLA-A	1.30e-03	48	23	2	GO:0002478
GeneOntologyBiologicalProcess	lymphocyte mediated immunity	HLA-H HLA-A MYO1G DPP4	1.41e-03	449	23	4	GO:0002449
GeneOntologyBiologicalProcess	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	HLA-H HLA-A MYO1G DPP4	1.57e-03	462	23	4	GO:0002460
GeneOntologyBiologicalProcess	regulation of T cell mediated cytotoxicity	HLA-H HLA-A	1.58e-03	53	23	2	GO:0001914
GeneOntologyCellularComponent	MHC class Ib protein complex	HLA-H HLA-A	2.42e-05	7	23	2	GO:0032398
GeneOntologyCellularComponent	MHC class I protein complex	HLA-H HLA-A	5.18e-05	10	23	2	GO:0042612
GeneOntologyCellularComponent	MHC class I peptide loading complex	HLA-H HLA-A	1.05e-04	14	23	2	GO:0042824
GeneOntologyCellularComponent	cis-Golgi network membrane	HLA-H HLA-A	1.56e-04	17	23	2	GO:0033106
GeneOntologyCellularComponent	Golgi medial cisterna	HLA-H HLA-A	2.89e-04	23	23	2	GO:0005797
GeneOntologyCellularComponent	MHC protein complex	HLA-H HLA-A	3.70e-04	26	23	2	GO:0042611
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-H HLA-A	6.74e-04	35	23	2	GO:0098553
GeneOntologyCellularComponent	endoplasmic reticulum exit site	HLA-H HLA-A	9.71e-04	42	23	2	GO:0070971
GeneOntologyCellularComponent	lumenal side of membrane	HLA-H HLA-A	1.27e-03	48	23	2	GO:0098576
GeneOntologyCellularComponent	recycling endosome	HLA-H HLA-A VPS53	1.79e-03	222	23	3	GO:0055037
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	HLA-H HLA-A	2.24e-03	64	23	2	GO:0012507
GeneOntologyCellularComponent	phagocytic vesicle membrane	HLA-H HLA-A	3.73e-03	83	23	2	GO:0030670
GeneOntologyCellularComponent	cis-Golgi network	HLA-H HLA-A	3.91e-03	85	23	2	GO:0005801
GeneOntologyCellularComponent	COPII-coated ER to Golgi transport vesicle	HLA-H HLA-A	6.46e-03	110	23	2	GO:0030134
GeneOntologyCellularComponent	recycling endosome membrane	HLA-H HLA-A	6.69e-03	112	23	2	GO:0055038
GeneOntologyCellularComponent	membrane raft	HLA-H HLA-A DPP4	7.05e-03	362	23	3	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	HLA-H HLA-A DPP4	7.16e-03	364	23	3	GO:0098857
GeneOntologyCellularComponent	endoplasmic reticulum protein-containing complex	HLA-H HLA-A	8.27e-03	125	23	2	GO:0140534
GeneOntologyCellularComponent	endocytic vesicle	HLA-H HLA-A DPP4	8.29e-03	384	23	3	GO:0030139
GeneOntologyCellularComponent	Golgi cisterna	HLA-H HLA-A	9.58e-03	135	23	2	GO:0031985
GeneOntologyCellularComponent	Golgi apparatus subcompartment	HLA-H HLA-A VPS53	1.22e-02	443	23	3	GO:0098791
GeneOntologyCellularComponent	phagocytic vesicle	HLA-H HLA-A	1.28e-02	157	23	2	GO:0045335
GeneOntologyCellularComponent	lysosomal membrane	HLA-H HLA-A DPP4	1.37e-02	462	23	3	GO:0005765
GeneOntologyCellularComponent	lytic vacuole membrane	HLA-H HLA-A DPP4	1.37e-02	462	23	3	GO:0098852
GeneOntologyCellularComponent	Golgi stack	HLA-H HLA-A	1.50e-02	171	23	2	GO:0005795
MousePheno	spinal cord inflammation	HLA-H HLA-A	3.88e-05	8	17	2	MP:0030987
Domain	ZINC_FINGER_C2H2_2	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	1.69e-07	775	23	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	1.72e-07	777	23	9	PS00028
Domain	Znf_C2H2-like	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	2.11e-07	796	23	9	IPR015880
Domain	Znf_C2H2	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	2.33e-07	805	23	9	IPR007087
Domain	ZnF_C2H2	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	2.40e-07	808	23	9	SM00355
Domain	-	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF83	8.84e-07	679	23	8	3.30.160.60
Domain	zf-C2H2	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF83	1.03e-06	693	23	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF83	1.04e-06	694	23	8	IPR013087
Domain	MHC_I_a_C	HLA-H HLA-A	2.17e-05	6	23	2	IPR010579
Domain	MHC_I_C	HLA-H HLA-A	2.17e-05	6	23	2	PF06623
Domain	zf-C2H2_6	ZNF442 ZNF564 ZNF14 ZNF93 ZNF251	3.41e-05	314	23	5	PF13912
Domain	KRAB	ZNF442 ZNF564 ZNF14 ZNF93 ZNF251	6.37e-05	358	23	5	PS50805
Domain	KRAB	ZNF442 ZNF564 ZNF14 ZNF93 ZNF251	6.37e-05	358	23	5	PF01352
Domain	KRAB	ZNF442 ZNF564 ZNF14 ZNF93 ZNF251	7.35e-05	369	23	5	SM00349
Domain	KRAB	ZNF442 ZNF564 ZNF14 ZNF93 ZNF251	7.45e-05	370	23	5	IPR001909
Domain	MHC_I_a_a1/a2	HLA-H HLA-A	3.00e-04	21	23	2	IPR001039
Domain	MHC_I	HLA-H HLA-A	3.00e-04	21	23	2	PF00129
Domain	C1-set	HLA-H HLA-A	2.00e-03	54	23	2	PF07654
Domain	IGc1	HLA-H HLA-A	2.15e-03	56	23	2	SM00407
Domain	Ig_C1-set	HLA-H HLA-A	2.30e-03	58	23	2	IPR003597
Domain	Ig/MHC_CS	HLA-H HLA-A	2.30e-03	58	23	2	IPR003006
Domain	IG_MHC	HLA-H HLA-A	2.46e-03	60	23	2	PS00290
Pathway	REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY	HLA-H HLA-A	4.90e-05	9	17	2	MM14527
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF442 ZNF14 ZNF93 RICTOR ZFHX3 PRMT5	1.89e-04	768	17	6	MM14851
Pathway	REACTOME_ER_PHAGOSOME_PATHWAY	HLA-H HLA-A	2.07e-04	18	17	2	MM14525
Pathway	BIOCARTA_CTL_PATHWAY	HLA-H HLA-A	2.57e-04	20	17	2	MM1374
Pathway	BIOCARTA_NKCELLS_PATHWAY	HLA-H HLA-A	4.04e-04	25	17	2	MM1465
Pathway	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	HLA-H HLA-A	4.04e-04	25	17	2	MM15713
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF442 HEY2 ZNF564 ZNF14 RICTOR ZFHX3 PRMT5	7.03e-04	1387	17	7	M734
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF442 ZNF14 ZNF93 RICTOR ZFHX3 PRMT5	8.83e-04	1022	17	6	MM15436
Pathway	REACTOME_DAP12_INTERACTIONS	HLA-H HLA-A	1.89e-03	54	17	2	MM14871
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF14 ZNF93	2.03e-03	56	17	2	MM17236
Pathway	WP_TAR_SYNDROME	HLA-A ZFHX3	2.56e-03	63	17	2	M48082
Pubmed	A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N).	HLA-H HLA-A	4.56e-07	2	24	2	10519371
Pubmed	Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells.	HLA-H HLA-A	9.56e-06	7	24	2	1348042
Pubmed	Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.	HLA-H HLA-A	9.56e-06	7	24	2	6088985
Pubmed	Molecular organization of the D-Qa region of t-haplotypes suggests that recombination is an important mechanism for generating genetic diversity of the major histocompatibility complex.	HLA-H HLA-A	9.56e-06	7	24	2	1686840
Pubmed	Generation of a functional cDNA encoding the LdH2 class-I molecule by using a single-LTR retroviral shuttle vector.	HLA-H HLA-A	9.56e-06	7	24	2	1705528
Pubmed	Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.	HLA-H HLA-A	9.56e-06	7	24	2	10023770
Pubmed	Different exon-intron organization at the 5' part of a mouse class I gene is used to generate a novel H-2Kd-related mRNA.	HLA-H HLA-A	9.56e-06	7	24	2	6143316
Pubmed	Manufacture of a functional cDNA for the H-2Db molecule using a retroviral shuttle vector.	HLA-H HLA-A	9.56e-06	7	24	2	1713192
Pubmed	Further studies on polymorphic expression of GM1 and GD1a in mouse liver. The presence of a third allele on the Ggm-1 locus.	HLA-H HLA-A	9.56e-06	7	24	2	2808323
Pubmed	Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.	HLA-H HLA-A	9.56e-06	7	24	2	9770513
Pubmed	Primary structure of murine major histocompatibility complex alloantigens. Amino acid sequence of the NH2-terminal ninety-eight residues of the H-2Db glycoprotein.	HLA-H HLA-A	9.56e-06	7	24	2	7225204
Pubmed	CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells.	HLA-H HLA-A	9.56e-06	7	24	2	21088134
Pubmed	H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.	HLA-H HLA-A	9.56e-06	7	24	2	19346486
Pubmed	MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling.	HLA-H HLA-A	9.56e-06	7	24	2	34181639
Pubmed	The Tla locus: a new allele and antigenic specificity.	HLA-H HLA-A	9.56e-06	7	24	2	69663
Pubmed	Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells.	HLA-H HLA-A	9.56e-06	7	24	2	18383043
Pubmed	MHC class I genes are not imprinted in the mouse placenta.	HLA-H HLA-A	9.56e-06	7	24	2	8206527
Pubmed	Thymus-dependent memory phenotype CD8 T cells in naive B6.H-2Kb-/-Db-/- animals mediate an antigen-specific response against Listeria monocytogenes.	HLA-H HLA-A	9.56e-06	7	24	2	16272298
Pubmed	Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense.	HLA-H HLA-A	9.56e-06	7	24	2	12459592
Pubmed	Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells.	HLA-H HLA-A	9.56e-06	7	24	2	19195028
Pubmed	Tissue-specific expression of an unusual H-2 (class I)-related gene.	HLA-H HLA-A	9.56e-06	7	24	2	6956903
Pubmed	A physical map of the Q region of B1O.P.	HLA-H HLA-A	9.56e-06	7	24	2	8833240
Pubmed	Multiple sequences related to classical histocompatibility antigens in the mouse genome.	HLA-H HLA-A	9.56e-06	7	24	2	6264319
Pubmed	Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model.	HLA-H HLA-A	9.56e-06	7	24	2	21178009
Pubmed	Expression and function of transplantation antigens with altered or deleted cytoplasmic domains.	HLA-H HLA-A	9.56e-06	7	24	2	6604582
Pubmed	Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.	HLA-H HLA-A	9.56e-06	7	24	2	6815535
Pubmed	Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.	HLA-H HLA-A	9.56e-06	7	24	2	3456611
Pubmed	Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.	HLA-H HLA-A	9.56e-06	7	24	2	15809355
Pubmed	Sequence analysis of the C3H H-2K1k gene: relationship to the H-2 loci.	HLA-H HLA-A	9.56e-06	7	24	2	2714856
Pubmed	Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells.	HLA-H HLA-A	9.56e-06	7	24	2	10500200
Pubmed	Structural definition of the H-2Kd peptide-binding motif.	HLA-H HLA-A	9.56e-06	7	24	2	16473882
Pubmed	Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.	HLA-H HLA-A	9.56e-06	7	24	2	6954478
Pubmed	The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC".	HLA-H HLA-A	9.56e-06	7	24	2	16210630
Pubmed	HLA-G transgenic mice.	HLA-H HLA-A	9.56e-06	7	24	2	10479061
Pubmed	Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo.	HLA-H HLA-A	9.56e-06	7	24	2	12902470
Pubmed	Structural analysis of H-2Kf and H-2Kfm1 by using H-2K locus-specific sequences.	HLA-H HLA-A	9.56e-06	7	24	2	2391419
Pubmed	Optimized tetramer analysis reveals Ly49 promiscuity for MHC ligands.	HLA-H HLA-A	9.56e-06	7	24	2	24154624
Pubmed	CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.	HLA-H HLA-A	9.56e-06	7	24	2	34525366
Pubmed	Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver.	HLA-H HLA-A	9.56e-06	7	24	2	3838699
Pubmed	Expression of the Qa-2k phenotype encoded by the Q5k gene on the surface of tumor cells derived from H-2k mice.	HLA-H HLA-A	9.56e-06	7	24	2	1740659
Pubmed	The H-2Kkml mutation: a single nucleotide substitution is responsible for multiple functional differences in a class I MHC molecule.	HLA-H HLA-A	9.56e-06	7	24	2	3374494
Pubmed	Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.	HLA-H HLA-A	9.56e-06	7	24	2	3840195
Pubmed	Extensive deletions in the Q region of the mouse major histocompatibility complex.	HLA-H HLA-A	9.56e-06	7	24	2	3025084
Pubmed	DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence.	HLA-H HLA-A	9.56e-06	7	24	2	2543831
Pubmed	Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats.	HLA-H HLA-A	9.56e-06	7	24	2	15671142
Pubmed	GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS.	HLA-H HLA-A	9.56e-06	7	24	2	14215561
Pubmed	Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells.	HLA-H HLA-A	9.56e-06	7	24	2	1540549
Pubmed	Structural relationships among the H-2 D-regions of murine MHC haplotypes.	HLA-H HLA-A	9.56e-06	7	24	2	2909618
Pubmed	Mouse histocompatibility genes: structure and organisation of a Kd gene.	HLA-H HLA-A	9.56e-06	7	24	2	11894934
Pubmed	Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis.	HLA-H HLA-A	9.56e-06	7	24	2	19700752
Pubmed	A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity.	HLA-H HLA-A	9.56e-06	7	24	2	28234229
Pubmed	The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.	HLA-H HLA-A	9.56e-06	7	24	2	11894963
Pubmed	Interaction of H-2Db with mutant histocompatibility gene H (KH-11) in the mouse.	HLA-H HLA-A	9.56e-06	7	24	2	6242891
Pubmed	Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.	HLA-H HLA-A	9.56e-06	7	24	2	16836618
Pubmed	Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.	HLA-H HLA-A	9.56e-06	7	24	2	22287714
Pubmed	Characterization of a severe parenchymal phenotype of experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice.	HLA-H HLA-A	9.56e-06	7	24	2	17512611
Pubmed	Family organization of mouse H-2 class I genes.	HLA-H HLA-A	9.56e-06	7	24	2	3997208
Pubmed	The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H-2Dd, not Qa/Tla.	HLA-H HLA-A	9.56e-06	7	24	2	2989712
Pubmed	The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens.	HLA-H HLA-A	9.56e-06	7	24	2	3263465
Pubmed	Amino acid sequence of residues 1-98 of the K-2Kb murine major histocompatibility alloantigen: comparison with H-2Kb and H-2db reveals extensive localized differences.	HLA-H HLA-A	9.56e-06	7	24	2	7018573
Pubmed	Unique biochemical properties of a mutant MHC class I molecule, H-2Ksm1.	HLA-H HLA-A	9.56e-06	7	24	2	1280760
Pubmed	Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.	HLA-H HLA-A	9.56e-06	7	24	2	2997361
Pubmed	Expression of GM1 and GD1a in mouse liver is linked to the H-2 complex on chromosome 17.	HLA-H HLA-A	9.56e-06	7	24	2	6671979
Pubmed	Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.	HLA-H HLA-A	9.56e-06	7	24	2	6786753
Pubmed	Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus.	HLA-H HLA-A	9.56e-06	7	24	2	6583704
Pubmed	The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.	HLA-H HLA-A	9.56e-06	7	24	2	18974374
Pubmed	Structural analysis of H-2Kj and H-2Ku.	HLA-H HLA-A	9.56e-06	7	24	2	8168857
Pubmed	BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs.	HLA-H HLA-A	9.56e-06	7	24	2	20534453
Pubmed	Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer.	HLA-H HLA-A	9.56e-06	7	24	2	6571712
Pubmed	Nucleotide sequences of three H-2K and three H-2D complementary DNA clones coding mouse class I MHC heavy chain proteins.	HLA-H HLA-A	9.56e-06	7	24	2	9869916
Pubmed	The H-2Kk MHC peptide-binding groove anchors the backbone of an octameric antigenic peptide in an unprecedented mode.	HLA-H HLA-A	9.56e-06	7	24	2	16148128
Pubmed	Mutation of a major histocompatibility class I locus, H-2D, leads to an increased virus burden and disease susceptibility in Theiler's virus-induced demyelinating disease.	HLA-H HLA-A	9.56e-06	7	24	2	9222352
Pubmed	Probing for membrane domains in the endoplasmic reticulum: retention and degradation of unassembled MHC class I molecules.	HLA-H HLA-A	9.56e-06	7	24	2	12006653
Pubmed	CD8+ T cells require perforin to clear West Nile virus from infected neurons.	HLA-H HLA-A	9.56e-06	7	24	2	16352536
Pubmed	The role of the MHC on resistance to group a streptococci in mice.	HLA-H HLA-A	9.56e-06	7	24	2	16148132
Pubmed	Three spontaneous H-2Db mutants are generated by genetic micro-recombination (gene conversion) events. Impact on the H-2-restricted immune responsiveness.	HLA-H HLA-A	9.56e-06	7	24	2	3199070
Pubmed	Expression of H-2K major histocompatibility antigens on preimplantation mouse embryos.	HLA-H HLA-A	9.56e-06	7	24	2	8481472
Pubmed	Changes in the coding sequence of the H-2Dk gene of metastatic cells that might account for immunogenic abnormality of its encoded antigen.	HLA-H HLA-A	9.56e-06	7	24	2	1699529
Pubmed	Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.	HLA-H HLA-A	9.56e-06	7	24	2	312902
Pubmed	Induction of the H-2 D antigen during B cell activation.	HLA-H HLA-A	9.56e-06	7	24	2	2642506
Pubmed	A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.	HLA-H HLA-A	9.56e-06	7	24	2	9037062
Pubmed	A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.	HLA-H HLA-A	9.56e-06	7	24	2	15520861
Pubmed	Distinctive interactions at multiple site 2 subsites by allele-specific rat and mouse ly49 determine functional binding and class I MHC specificity.	HLA-H HLA-A	9.56e-06	7	24	2	17982076
Pubmed	A single-chain H-2Db molecule presenting an influenza virus nucleoprotein epitope shows enhanced ability at stimulating CD8+ T cell responses in vivo.	HLA-H HLA-A	9.56e-06	7	24	2	19342630
Pubmed	Identification of an H-2 Kb-presented Moloney murine leukemia virus cytotoxic T-lymphocyte epitope that displays enhanced recognition in H-2 Db mutant bm13 mice.	HLA-H HLA-A	9.56e-06	7	24	2	7520098
Pubmed	Nucleic acid sequences of the H-2Ks and H-2Ksm1 genes.	HLA-H HLA-A	9.56e-06	7	24	2	1840571
Pubmed	Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense.	HLA-H HLA-A	9.56e-06	7	24	2	16476767
Pubmed	Influence of xenogeneic beta2-microglobulin on functional recognition of H-2Kb by the NK cell inhibitory receptor Ly49C.	HLA-H HLA-A	9.56e-06	7	24	2	16148097
Pubmed	Serological analysis of H-2 mutations using monoclonal antibodies.	HLA-H HLA-A	9.56e-06	7	24	2	6084033
Pubmed	Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.	HLA-H HLA-A	9.56e-06	7	24	2	20957233
Pubmed	Insertion of the B2 sequence into intron 13 is the only defect of the H-2k C4 gene which causes low C4 production.	HLA-H HLA-A	9.56e-06	7	24	2	1329034
Pubmed	DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen.	HLA-H HLA-A	9.56e-06	7	24	2	7058332
Pubmed	Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance.	HLA-H HLA-A	9.56e-06	7	24	2	15644207
Pubmed	How a single T cell receptor recognizes both self and foreign MHC.	HLA-H HLA-A	9.56e-06	7	24	2	17418792
Pubmed	Inactivation of the H-2Klk gene could involve the substitutions of methylated CpGs.	HLA-H HLA-A	9.56e-06	7	24	2	2212699
Pubmed	PCR identification of class I major histocompatibility complex genes transcribed in mouse blastocyst and placenta.	HLA-H HLA-A	9.56e-06	7	24	2	9185075
Pubmed	Zooming in on the hydrophobic ridge of H-2D(b): implications for the conformational variability of bound peptides.	HLA-H HLA-A	9.56e-06	7	24	2	11580250
Pubmed	Complete nucleotide sequence of the murine H-2Kk gene. Comparison of three H-2K locus alleles.	HLA-H HLA-A	9.56e-06	7	24	2	6096831
Pubmed	V beta T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules.	HLA-H HLA-A	9.56e-06	7	24	2	11086076
Pubmed	Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes.	HLA-H HLA-A	9.56e-06	7	24	2	24101547
Cytoband	19p13.2	ZNF442 ZNF564	6.36e-03	229	24	2	19p13.2
Cytoband	6p21.3	HLA-H HLA-A	7.53e-03	250	24	2	6p21.3
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF442 ZNF564 ZNF14	8.04e-03	797	24	3	chr19p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF35 ZNF442 ZNF564 ZNF14 ZNF93 ZNF251 ZFHX3 ZNF609 ZNF83	8.24e-09	718	18	9	28
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-H HLA-A	8.64e-04	44	18	2	588
Coexpression	RUAN_RESPONSE_TO_TNF_UP	HLA-H HLA-A THRSP	8.87e-07	21	24	3	MM651
Coexpression	HOWLIN_CITED1_TARGETS_1_UP	HLA-H HLA-A DPP4	7.03e-06	41	24	3	MM710
Coexpression	TABULA_MURIS_SENIS_LUNG_ENDOTHELIAL_CELL_OF_LYMPHATIC_VESSEL_AGEING	HLA-H HLA-A	9.57e-05	16	24	2	MM3766
Coexpression	CAHOY_ASTROCYTIC	HEY2 ELF5 THRSP	1.03e-04	100	24	3	M2806
Coexpression	WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_DN	HLA-H HLA-A	1.36e-04	19	24	2	MM797
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K27ME3	HLA-H HLA-A	1.36e-04	19	24	2	MM862
Coexpression	TABULA_MURIS_SENIS_BLADDER_LEUKOCYTE_AGEING	HLA-H HLA-A	1.51e-04	20	24	2	MM3682
Coexpression	TABULA_MURIS_SENIS_HEART_VALVE_CELL_AGEING	HLA-H HLA-A ZFHX3	2.04e-04	126	24	3	MM3709
Coexpression	TABULA_MURIS_SENIS_LUNG_PULMONARY_INTERSTITIAL_FIBROBLAST_AGEING	HLA-H HLA-A	2.19e-04	24	24	2	MM3773
Coexpression	RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP	HLA-H HLA-A	2.38e-04	25	24	2	MM672
Coexpression	BLANCO_MELO_BRONCHIAL_EPITHELIAL_CELLS_INFLUENZA_A_DEL_NS1_INFECTION_UP	HLA-H HLA-A ZNF442 DPP4 RICTOR	2.54e-04	644	24	5	M34026
Drug	valdecoxib; Down 200; 10uM; PC3; HT_HG-U133A	ZNF442 VPS53 DPP4 ZNF609	4.23e-05	197	23	4	6408_DN
Drug	ahz	HLA-A ZFHX3	4.75e-04	32	23	2	CID000656929
Drug	dibenzothiophene	ZNF35 HLA-A	5.69e-04	35	23	2	CID000003023
Drug	ceric oxide	HLA-H HLA-A	7.07e-04	39	23	2	ctd:C030583
Drug	Chloroquine diphosphate [50-63-5]; Down 200; 7.8uM; MCF7; HT_HG-U133A	ZNF93 VPS53 ZNF609	8.96e-04	190	23	3	2869_DN
Drug	Acetaminophen [103-90-2]; Down 200; 26.4uM; MCF7; HT_HG-U133A	ZNF442 ZNF93 ZNF609	9.51e-04	194	23	3	5384_DN
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZNF93 ZFHX3 ZNF609	9.51e-04	194	23	3	4335_DN
Drug	2-propylpentanoic acid; Up 200; 200uM; HL60; HT_HG-U133A	ZNF93 DPP4 ZFHX3	9.51e-04	194	23	3	6173_UP
Drug	Flunisolide [3385-03-3]; Down 200; 9.2uM; HL60; HT_HG-U133A	ZNF93 VPS53 ZNF609	9.66e-04	195	23	3	2168_DN
Drug	Minaprine dihydrochloride [25953-17-7]; Up 200; 10.8uM; MCF7; HT_HG-U133A	ZNF442 DPP4 ZNF609	9.66e-04	195	23	3	4814_UP
Drug	Alfaxalone [23930-19-0]; Down 200; 12uM; HL60; HT_HG-U133A	ZNF93 VPS53 ZNF609	9.66e-04	195	23	3	3135_DN
Drug	Trapidil [15421-84-8]; Down 200; 19.4uM; HL60; HT_HG-U133A	ZNF93 ZFHX3 ZNF609	9.80e-04	196	23	3	3136_DN
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HT_HG-U133A	ZNF442 VPS53 ZNF609	9.80e-04	196	23	3	4656_DN
Drug	CP-690334-01 [459212-38-5]; Up 200; 1uM; PC3; HT_HG-U133A	HEY2 VPS53 ZNF609	9.80e-04	196	23	3	3826_UP
Drug	Cisapride [81098-60-4]; Down 200; 8.6uM; HL60; HT_HG-U133A	ZNF35 VPS53 ZNF609	9.80e-04	196	23	3	2443_DN
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	ZNF93 VPS53 ZNF609	9.80e-04	196	23	3	1151_UP
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; MCF7; HT_HG-U133A	HEY2 VPS53 ZNF609	9.80e-04	196	23	3	4359_DN
Drug	D-cycloserine [68-41-7]; Down 200; 39.2uM; MCF7; HT_HG-U133A	ZNF35 ZNF442 ZNF609	9.80e-04	196	23	3	6782_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; PC3; HT_HG-U133A	ZNF93 VPS53 ZNF609	9.80e-04	196	23	3	4624_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	HEY2 ZNF93 ZNF609	9.80e-04	196	23	3	1511_DN
Drug	Skimmianine [83-95-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	ZNF442 ZNF93 ZNF609	9.94e-04	197	23	3	5766_DN
Drug	Betulin [473-98-3]; Up 200; 9uM; MCF7; HT_HG-U133A	HEY2 DPP4 ZNF609	9.94e-04	197	23	3	3513_UP
Drug	resorcinol	ZNF442 ZNF564 ZNF14	9.94e-04	197	23	3	ctd:C031389
Drug	Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; MCF7; HT_HG-U133A	ZNF442 VPS53 DPP4	9.94e-04	197	23	3	4986_DN
Drug	Stachydrine hydrochloride; Down 200; 22.2uM; MCF7; HT_HG-U133A	ZNF442 VPS53 ZNF609	9.94e-04	197	23	3	6805_DN
Drug	Lincomycin hydrochloride [859-18-7]; Up 200; 9uM; MCF7; HT_HG-U133A	VPS53 DPP4 ZNF609	9.94e-04	197	23	3	7411_UP
Drug	estradiol, USP; Up 200; 0.01uM; MCF7; HG-U133A	ZNF35 ZNF14 ZFHX3	9.94e-04	197	23	3	121_UP
Drug	Atropine sulfate monohydrate [5908-99-6]; Up 200; 5.8uM; MCF7; HT_HG-U133A	ZNF442 HEY2 ELF5	9.94e-04	197	23	3	2761_UP
Drug	Minaprine dihydrochloride [25953-17-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	ZNF35 ZNF442 ZFHX3	9.94e-04	197	23	3	1468_DN
Drug	Hemicholinium bromide [312-45-8]; Down 200; 7uM; MCF7; HT_HG-U133A	ZNF442 ZNF93 ZNF609	9.94e-04	197	23	3	3216_DN
Drug	Fenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	ZNF442 ZNF93 ZNF609	1.01e-03	198	23	3	2106_UP
Drug	(R)-(+)-Atenolol [56715-13-0]; Up 200; 15uM; MCF7; HT_HG-U133A	FAM124B HEY2 DPP4	1.01e-03	198	23	3	4841_UP
Drug	Phenethicillin potassium salt [132-93-4]; Down 200; 10uM; HL60; HT_HG-U133A	ZNF93 ZFHX3 ZNF609	1.01e-03	198	23	3	2542_DN
Drug	Tomatidine [77-59-8]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ZNF14 ZNF93 ZNF83	1.01e-03	198	23	3	7166_DN
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; PC3; HT_HG-U133A	DPP4 ZFHX3 ZNF609	1.01e-03	198	23	3	4252_DN
Drug	Lithocholic acid [434-13-9]; Down 200; 10.6uM; PC3; HT_HG-U133A	ZNF442 ZNF93 VPS53	1.01e-03	198	23	3	4551_DN
Drug	CP-645525-01 [287190-82-3]; Up 200; 10uM; MCF7; HT_HG-U133A	ZNF35 VPS53 ZNF609	1.01e-03	198	23	3	7515_UP
Drug	haloperidol; Up 200; 10uM; HL60; HT_HG-U133A	ZNF93 VPS53 ZFHX3	1.01e-03	198	23	3	6163_UP
Drug	Dydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ZNF442 DPP4 ZNF609	1.01e-03	198	23	3	4836_UP
Drug	Niacin [59-67-6]; Up 200; 32.4uM; PC3; HT_HG-U133A	ZNF93 VPS53 ZNF609	1.01e-03	198	23	3	6702_UP
Drug	Cefadroxil [50370-12-2]; Down 200; 11uM; MCF7; HT_HG-U133A	ZNF35 ZNF93 ZNF609	1.01e-03	198	23	3	3259_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	ZNF93 VPS53 ZNF609	1.01e-03	198	23	3	4536_DN
Disease	glycoprotein measurement	HLA-A ZFHX3 ELF5	1.07e-04	119	23	3	EFO_0004555
Disease	serum IgE measurement	HLA-H HLA-A	1.14e-03	64	23	2	EFO_0004579
Disease	obsolete aging	HLA-A MYO1G ZFHX3	1.29e-03	279	23	3	GO_0007568
Disease	esophagus squamous cell carcinoma (is_marker_for)	DPP4 RICTOR	1.52e-03	74	23	2	DOID:3748 (is_marker_for)
Disease	squamous cell lung carcinoma, family history of lung cancer	FAM124B MYO1G	1.99e-03	85	23	2	EFO_0000708, EFO_0006953
Disease	non-alcoholic fatty liver disease, type 2 diabetes mellitus	VPS53 RICTOR	3.31e-03	110	23	2	EFO_0003095, MONDO_0005148
Disease	lymphocyte measurement	HLA-A MYO1G	3.73e-03	117	23	2	EFO_0803546
Disease	prostate carcinoma	HLA-A UPF2 VPS53 ZFHX3	4.63e-03	891	23	4	EFO_0001663
Disease	basophil count	HLA-H HLA-A MYO1G	6.05e-03	483	23	3	EFO_0005090
Disease	nasopharyngeal neoplasm	HLA-A ZFHX3	6.13e-03	151	23	2	EFO_0004252
Disease	colorectal cancer (is_marker_for)	RICTOR ZFHX3	6.61e-03	157	23	2	DOID:9256 (is_marker_for)
Disease	brain measurement, neuroimaging measurement	HEY2 DPP4 ZFHX3	8.64e-03	550	23	3	EFO_0004346, EFO_0004464

Protein segments in the cluster

Peptide	Gene	Start	Entry
HTRILTLSHMHTHAH	nan	106	Q6ZRP5
CTLTSTITHMHTHTH	nan	161	Q6ZRP5
TLTLTHTHMHTFLSL	nan	186	Q6ZRP5
HTHMHTFLSLVSHLA	nan	191	Q6ZRP5
HSHRVMLDSVTHSTF	ELF5	6	Q9UKW6
THMTHHPISDHEATL	HLA-H	211	P01893
MVHSLLHRLSHNDHI	CT47A1	126	Q5JQC4
AAAMTSSMAHHHHPL	HEY2	166	Q9UBP5
TAHQHIYTHMSHFIK	DPP4	746	P27487
LHMANTILPHSHSHH	RICTOR	431	Q6R327
HLHLSSHHLESGARM	FAM124B	331	Q9H5Z6
RVLTNHIHTGHHSSM	PRMT5	136	O14744
THMTHHPISDHEATL	HLA-A	211	P04439
HCLKMLLSDFSHHHI	UPF2	686	Q9HAU5
VMCHALSHLHAMLHT	OR1Q1	146	Q15612
VFMHHSSLSRHIRSH	ZNF564	111	Q8TBZ8
FHLSTHLTTHKILHT	ZNF93	546	P35789
FISNSHLMRHHRTHL	ZNF35	511	P13682
EMESLSARHSHSHHT	UNC80	531	Q8N2C7
TSPSQRLMSTHHHHH	ZNF609	1356	O15014
HLTTSITTLNHLHML	VPS53	141	Q5VIR6
LSHHSSFRSHMIMHT	ZNF442	386	Q9H7R0
FTHSSNLVLHHHIHT	ZNF251	246	Q9BRH9
AQFHLHFSSLHHILM	THRSP	111	Q92748
HFSSLHHILMHLTEK	THRSP	116	Q92748
FSMRSSLTNHHAIHT	ZNF83	466	P51522
DFIHHSSLNRHMRSH	ZNF14	111	P17017
SFVTHAVHDHRMTLS	ZFHX3	296	Q15911
TLDMHHRHHLHYTSR	MYO1G	486	B0I1T2