Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentcohesin complex

STAG1 STAG3

1.75e-0411382GO:0008278
DomainSCD

STAG1 STAG3

2.29e-054372PS51425
DomainSCD

STAG1 STAG3

2.29e-054372IPR020839
DomainSTAG

STAG1 STAG3

2.29e-054372PF08514
DomainSTAG

STAG1 STAG3

2.29e-054372IPR013721
DomainZnf_C2H2/integrase_DNA-bd

HIVEP3 RAG1 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

3.69e-04694377IPR013087
DomainZnf_C2H2-like

HIVEP3 RAG1 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

8.36e-04796377IPR015880
DomainZnF_C2H2

HIVEP3 RAG1 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

9.13e-04808377SM00355
Domain-

HIVEP3 RAG1 ZNF778 PRDM14 ZNF541 ZNF404

2.01e-036793763.30.160.60
Domainzf-C2H2

HIVEP3 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

2.22e-03693376PF00096
DomainZINC_FINGER_C2H2_2

HIVEP3 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

3.87e-03775376PS50157
DomainZINC_FINGER_C2H2_1

HIVEP3 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

3.92e-03777376PS00028
DomainWW_DOMAIN_2

ARHGAP39 IQGAP2

4.58e-0351372PS50020
DomainWW_DOMAIN_1

ARHGAP39 IQGAP2

4.58e-0351372PS01159
DomainZnf_C2H2

HIVEP3 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

4.66e-03805376IPR007087
DomainWW_dom

ARHGAP39 IQGAP2

4.76e-0352372IPR001202
PathwayREACTOME_RAC1_GTPASE_CYCLE

FGD5 ARHGAP39 IQGAP2 CYFIP2

2.37e-04175254MM15599
PathwayREACTOME_RAC1_GTPASE_CYCLE

FGD5 ARHGAP39 IQGAP2 CYFIP2

2.87e-04184254M41809
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

DNAJA3 RAG1 GLT6D1 NUDT6 IQGAP2 FGGY

1.10e-0631338620800603
Pubmed

Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks.

RAG1 DICER1

1.16e-06238223427252
Pubmed

Embryonic expression and regulation of the large zinc finger protein KRC.

HIVEP3 RAG1

1.16e-06238212001065
Pubmed

MicroRNA-155 drives TH17 immune response and tissue injury in experimental crescentic GN.

RAG1 DICER1

3.48e-06338223949802
Pubmed

MicroRNA-deficient NK cells exhibit decreased survival but enhanced function.

RAG1 DICER1

3.48e-06338222379033
Pubmed

VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation.

RAG1 DICER1

6.96e-06438229925675
Pubmed

STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.

STAG1 STAG3

1.16e-05538212034751
Pubmed

Cryo-EM structure of the human cohesin-NIPBL-DNA complex.

STAG1 STAG3

1.74e-05638232409525
Pubmed

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors.

RAG1 PPARD

4.16e-05938232066953
Pubmed

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression.

RAG1 DICER1

4.16e-05938227332731
Pubmed

RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis.

STAG1 STAG3

5.20e-051038221242291
Pubmed

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

NEB CYFIP2

5.20e-051038215048123
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNAJA3 FGD5 RPL35A URB2 DICER1 SUPT6H CYFIP2 NEMF

1.27e-04142538830948266
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

GATB KDELR2 NEB STAG1 IQGAP2 ERLIN1 ZNF541 CYFIP2

1.38e-04144238835575683
Pubmed

Programme of self-reactive innate-like T cell-mediated cancer immunity.

RAG1 FGD5

1.38e-041638235444279
Pubmed

STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.

STAG1 STAG3

2.18e-042038224797475
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

NEB ERLIN1

4.01e-042738218468998
Pubmed

HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.

MYO3A DICER1

6.38e-043438225925205
Pubmed

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

GATB DNAJA3 RPL35A IQGAP2

9.34e-0440038435013556
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

RPL35A URB2 ARHGAP39 DICER1 SUPT6H ERLIN1 CYFIP2

1.05e-03149738731527615
GeneFamilyCohesin complex

STAG1 STAG3

4.31e-0582321060
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

HIVEP3 ZNF778 PRDM14 ZNF177 ZNF541 ZNF404

2.17e-0471823628
DrugPyrvinium pamoate [3546-41-6]; Down 200; 3.4uM; PC3; HT_HG-U133A

HIVEP3 CABIN1 SUPT6H STAG3 ERLIN1

1.75e-051953856339_DN
DrugChelidonine monohydrate (+) [476-32-4]; Up 200; 10.8uM; PC3; HT_HG-U133A

MYO3A NUDT6 PPARD FAM13C PRDM14

1.75e-051953855760_UP
DrugEtidronic acid, disodium salt [7414-83-7]; Up 200; 16uM; PC3; HT_HG-U133A

PPARD NEB FAM13C PRDM14 FAM135A

1.79e-051963854564_UP
Diseaseascending aortic diameter

HIVEP3 FGD5 FGGY

7.81e-04140383EFO_0021787
Diseasesquamous cell lung carcinoma

HIVEP3 NEB ERLIN1

1.25e-03165383EFO_0000708
DiseaseObesity

PPARD FGGY BBS10

2.33e-03205383C0028754

Protein segments in the cluster

PeptideGeneStartEntry
FKELYNDYLKYHKAK

URB2

1501

Q14146
EKAKADAEYYAAHKY

ERLIN1

256

O75477
NKKSLFDRKHYFYAD

GATB

131

O75879
ASLAVKYDYHKYFKA

DICER1

1746

Q9UPY3
KYDYHKYFKAVSPEL

DICER1

1751

Q9UPY3
FEILLHYYLLNYAKK

BBS10

606

Q8TAM1
KFKYRYEGKITNYFH

RAG1

926

P15918
TYAKYCYHKLQKAAL

ARHGAP39

846

Q9C0H5
SLSAYANAKKYYDHK

NEMF

466

O60524
ANAKKYYDHKRYAAK

NEMF

471

O60524
FLYKLSNKAGLHYFK

FAM135A

1401

Q9P2D6
LFYKLYHKELPENYK

NUDT6

296

P53370
LYHKKTLFYSFKAED

FGD5

1431

Q6ZNL6
FVYKLADQIFAYYKA

CYFIP2

726

Q96F07
SKKGDYLKYHYNASL

FKBP9

386

O95302
ELYYLLADYHFKNKE

CABIN1

1056

Q9Y6J0
TYEKHLNKYFYLNKP

GLT6D1

261

Q7Z4J2
YYDKKYQVFLKLVEH

FGGY

526

Q96C11
KAYYQLAKKYHPDTN

DNAJA3

111

Q96EY1
KKLHENYYAMYLKYL

CFAP47

631

Q6ZTR5
YLIYLKFKATYDGNH

KDELR2

76

P33947
FYLGKRCAYVYKAKN

RPL35A

41

P18077
GKVFTYKYYRDKHLK

PRDM14

406

Q9GZV8
KAFSKHIYNAYLKNF

PPARD

176

Q03181
DEHKSLKYKYKDYHT

FER1L5

1396

A0AVI2
RKGLDQDYYKALHYF

SEL1L2

311

Q5TEA6
QDYYKALHYFLKAAK

SEL1L2

316

Q5TEA6
LKLNLHKKYDYYYNT

IQGAP2

601

Q13576
ADEYYEYKHIKAKLR

FAM13C

556

Q8NE31
YKEFLSKNFQKHMYY

COA8

156

Q96IL0
AHYAYSFKYLKNKPV

SUPT6H

631

Q7KZ85
AYNRFYLLKEHLKTY

ZNF778

681

Q96MU6
KCYKYIKYSKVFNHP

ZNF177

146

Q13360
KHYNKFYNDYGDIIK

STAG3

896

Q9UJ98
RYKKRDNYEAHKKYY

HIVEP3

651

Q5T1R4
KHYMKYYNDYGDIIK

STAG1

891

Q8WVM7
YECKEYKKGFRKYLH

ZNF404

131

Q494X3
RLFKKAFYAHKKDFY

ZNF541

1171

Q9H0D2
YKSYLEAFYKFCKNH

ATP6V0D2

186

Q8N8Y2
YIYAGLAEKKKLAHY

MYO3A

531

Q8NEV4
KYKDSYLKDILGHYV

NEB

421

P20929
SDYKYKEAYRKQLGH

NEB

3276

P20929