Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2D KMT2A	1.51e-05	8	131	3	GO:0140945
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2D KMT2A	3.20e-05	10	131	3	GO:0140999
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1H CACNA1G	1.28e-04	3	131	2	GO:0008332
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	NSD1 KMT2C KMT2D KMT2A	1.96e-04	44	131	4	GO:0140938
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C KMT2D KMT2A	2.90e-04	20	131	3	GO:0042800
Domain	EPHD	TCF20 KMT2C KMT2D KMT2A RAI1	3.76e-07	22	131	5	PS51805
Domain	PHD	TCF20 NSD1 KMT2C KMT2D PHF3 KMT2A RAI1	3.04e-06	89	131	7	SM00249
Domain	FYrich_C	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	IPR003889
Domain	FYrich_N	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	IPR003888
Domain	FYRC	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	SM00542
Domain	FYRN	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	SM00541
Domain	FYRN	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	PF05964
Domain	FYRC	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	PF05965
Domain	FYRC	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	PS51543
Domain	FYRN	KMT2C KMT2D KMT2A	3.34e-06	5	131	3	PS51542
Domain	Znf_PHD	TCF20 NSD1 KMT2C KMT2D PHF3 KMT2A RAI1	3.53e-06	91	131	7	IPR001965
Domain	Post-SET_dom	NSD1 KMT2C KMT2D KMT2A	3.94e-06	16	131	4	IPR003616
Domain	PostSET	NSD1 KMT2C KMT2D KMT2A	3.94e-06	16	131	4	SM00508
Domain	POST_SET	NSD1 KMT2C KMT2D KMT2A	3.94e-06	16	131	4	PS50868
Domain	ZF_PHD_2	TCF20 NSD1 KMT2C KMT2D PHF3 KMT2A RAI1	4.70e-06	95	131	7	PS50016
Domain	ZF_PHD_1	TCF20 NSD1 KMT2C KMT2D PHF3 KMT2A RAI1	5.05e-06	96	131	7	PS01359
Domain	Znf_FYVE_PHD	TCF20 PCLO NSD1 KMT2C KMT2D PHF3 KMT2A ZFYVE26	9.30e-06	147	131	8	IPR011011
Domain	FAM193_C	FAM193B FAM193A	4.88e-05	2	131	2	PF15914
Domain	FAM193_C	FAM193B FAM193A	4.88e-05	2	131	2	IPR031802
Domain	FAM193	FAM193B FAM193A	4.88e-05	2	131	2	IPR029717
Domain	PL48	RIPOR3 RIPOR1	1.46e-04	3	131	2	PF15903
Domain	FAM65_N	RIPOR3 RIPOR1	1.46e-04	3	131	2	IPR031780
Domain	FAM65	RIPOR3 RIPOR1	1.46e-04	3	131	2	IPR026136
Domain	VDCC_T_a1	CACNA1H CACNA1G	1.46e-04	3	131	2	IPR005445
Domain	PHD	NSD1 KMT2C KMT2D PHF3 KMT2A	1.83e-04	75	131	5	PF00628
Domain	SET	NSD1 KMT2C KMT2D KMT2A	1.91e-04	41	131	4	PF00856
Domain	Znf_PHD-finger	NSD1 KMT2C KMT2D PHF3 KMT2A	2.34e-04	79	131	5	IPR019787
Domain	SET	NSD1 KMT2C KMT2D KMT2A	3.00e-04	46	131	4	SM00317
Domain	SET_dom	NSD1 KMT2C KMT2D KMT2A	4.15e-04	50	131	4	IPR001214
Domain	SET	NSD1 KMT2C KMT2D KMT2A	4.15e-04	50	131	4	PS50280
Domain	LNS2	LPIN2 PITPNM3	7.19e-04	6	131	2	IPR013209
Domain	LNS2	LPIN2 PITPNM3	7.19e-04	6	131	2	SM00775
Domain	SPOC_C	PHF3 SPOCD1	7.19e-04	6	131	2	IPR012921
Domain	LNS2	LPIN2 PITPNM3	7.19e-04	6	131	2	PF08235
Domain	LNS2/PITP	LPIN2 PITPNM3	7.19e-04	6	131	2	IPR031315
Domain	SPOC	PHF3 SPOCD1	7.19e-04	6	131	2	PF07744
Domain	TFS2M	PHF3 SPOCD1	1.00e-03	7	131	2	SM00510
Domain	DUF3585	BMERB1 MICALL1	1.00e-03	7	131	2	IPR022735
Domain	DUF3585	BMERB1 MICALL1	1.00e-03	7	131	2	PF12130
Domain	TFIIS_M	PHF3 SPOCD1	1.00e-03	7	131	2	PF07500
Domain	TFIIS_cen_dom	PHF3 SPOCD1	1.33e-03	8	131	2	IPR003618
Domain	Man6P_isomerase_rcpt-bd_dom	ELAPOR2 PRKCSH	1.33e-03	8	131	2	IPR009011
Domain	-	PHF3 SPOCD1	1.33e-03	8	131	2	1.10.472.30
Domain	TFIIS_CENTRAL	PHF3 SPOCD1	1.33e-03	8	131	2	PS51321
Domain	zf-C2H2_11	ZNF592 ZNF687	1.70e-03	9	131	2	PF16622
Domain	VDCCAlpha1	CACNA1H CACNA1G	2.12e-03	10	131	2	IPR002077
Domain	Oxysterol-bd_CS	OSBPL5 OSBPL7	3.08e-03	12	131	2	IPR018494
Domain	Oxysterol_BP	OSBPL5 OSBPL7	3.08e-03	12	131	2	PF01237
Domain	Oxysterol-bd	OSBPL5 OSBPL7	3.08e-03	12	131	2	IPR000648
Domain	OSBP	OSBPL5 OSBPL7	3.08e-03	12	131	2	PS01013
Domain	AT_hook	KMT2C KMT2A	5.49e-03	16	131	2	PF02178
Domain	PH	ARHGAP10 ARHGAP22 AFAP1L2 FARP1 OSBPL5 OSBPL7	5.58e-03	229	131	6	PF00169
Domain	HMG_box	HBP1 KMT2C KMT2D	6.12e-03	53	131	3	PF00505
Domain	HMG	HBP1 KMT2C KMT2D	6.44e-03	54	131	3	SM00398
Domain	Chromodomain_CS	CHD2 CBX6	6.94e-03	18	131	2	IPR023779
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SEC16B RAD18 ERCC5 TCF20 MAP4 CARMIL1 BRD3 POGZ RRBP1 CHAMP1 ADD1 CLASRP PAPOLG MICALL1 KANSL3 SCAF1 USP10 NCOR2 EPS15L1 KMT2D SSH1 ZNF592 PHF3 KMT2A PACS2 RIPOR1 TNKS1BP1 SRRM2 AKAP1 ZNF687	9.93e-22	774	133	30	15302935
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 FAM193B SPHK2 SHROOM3 KIF26A SPEG INPPL1 TSNARE1 NSD1 SFI1 MICALL1 PPP1R26 KANSL3 HIVEP3 NHSL1 SCAF1 KMT2C NCOR2 EPS15L1 KMT2D SSH1 ZNF592 PKD1 OSBPL5 RIPOR1 ZFYVE26 CACNA1H TNKS1BP1 ULK1 RAI1 ZNF687	2.06e-18	1105	133	31	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DENND2A SHROOM3 KIF26A E2F3 POGZ SFI1 RRBP1 CHAMP1 MICALL1 KANSL3 USP10 KMT2C UBXN4 ZNF592 HPS4 OSBPL5 TNKS1BP1 CACNA1G RAI1 ZNF687	1.72e-14	529	133	20	14621295
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	TSHZ3 SALL3 TCF20 BRD3 POGZ CHAMP1 ZNF592 KMT2A RAI1 ZNF687	8.28e-12	103	133	10	32744500
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	TSHZ3 RAD18 TCF20 NSD1 E2F3 CHD2 BRD3 POGZ MCM10 CHAMP1 PAPOLG NFATC2IP ZNF592 PHF3 ZSCAN18 KMT2A HDGFL2 RAI1	2.24e-11	608	133	18	36089195
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TCF20 AVL9 SPEG POGZ DCAF5 MAP7D1 PHF3 STARD9 PACS2 RIPOR1 CIPC CACNA1H ULK1 SRRM2	6.27e-10	407	133	14	12693553
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	RAD18 TCF20 NSD1 CHD2 BRD3 POGZ RRBP1 CHAMP1 CLASRP KANSL3 SCAF1 KMT2C NCOR2 MLXIPL MAP7D1 KMT2D YAF2 PHF3 KMT2A SRRM2 HDGFL2 RAI1 ZNF687	7.96e-10	1294	133	23	30804502
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	SPEG CARMIL1 PTPN22 CHD2 BRD3 RRBP1 LCP2 KMT2C MAP7D1 ZNF592 KMT2A HDGFL2 RAI1 ZNF687	8.02e-09	497	133	14	36774506
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHROOM3 MAP4 ARHGAP10 CARMIL1 TSNARE1 E2F3 CHD2 RRBP1 GALNT7 LARP4 KANSL3 HIVEP3 USP10 KMT2C NCOR2 EPS15L1 FARP1 OSBPL5 ZFHX2 RIPOR1 CACNA1H GNAS RAI1	1.12e-08	1489	133	23	28611215
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	XIRP1 TCF20 KIF26A SCAF1 KMT2C MAP7D1 PHF3 STARD9 OSBPL5 SRRM2	2.47e-08	233	133	10	37704626
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	CHD2 BRD3 CLASRP HELB KMT2C KMT2D SSH1 ZNF592 KMT2A CRYBG1 TNKS1BP1 EIF2A HDGFL2	3.40e-08	469	133	13	27634302
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	RAD18 ARHGAP10 BRD3 POGZ CHAMP1 SCAF1 KMT2C KMT2D KMT2A HDGFL2	4.97e-08	251	133	10	31076518
Pubmed	Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.	KMT2C KMT2D KMT2A	5.47e-08	3	133	3	23932714
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	TSHZ3 TCF20 POGZ CHAMP1 NCOR2 MAP7D1 KMT2D FAM193A ZNF592 TNKS1BP1 AKAP1 ZNF687	8.05e-08	418	133	12	34709266
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SEC16B MAP4 PTPN22 CDCP1 CLASRP SCAF1 MAP7D1 ZNF592 PHF3 NSUN5P2 SRRM2	1.58e-07	361	133	11	26167880
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TCF20 MAP4 NSD1 POGZ CHAMP1 ADD1 USP10 KMT2C EPS15L1 KMT2D PHF3 KMT2A TNKS1BP1	2.09e-07	549	133	13	38280479
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 TCF20 MAP4 CARMIL1 INPPL1 MICALL1 NHSL1 MLXIPL MAP7D1 PHF3 STARD9 KMT2A TNKS1BP1 GNAS SRRM2 AKAP1	2.09e-07	861	133	16	36931259
Pubmed	A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.	KMT2C KMT2D KMT2A	2.18e-07	4	133	3	23129768
Pubmed	The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.	KMT2C KMT2D KMT2A	2.18e-07	4	133	3	24081332
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	AVEN SEC16B MAP4 AVL9 STMN2 CHD2 POGZ RRBP1 LARP4 ADD1 KANSL3 SCAF1 USP10 MAP7D1 PHF3 STARD9 FARP1 KMT2A GNAS MGME1	2.82e-07	1371	133	20	36244648
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	RAD18 TCF20 MAP4 CHD2 BRD3 SIRT6 RRBP1 CHAMP1 KANSL3 USP10 NCOR2 ZNF592 PHF3 KMT2A EIF2A HDGFL2 ZNF687	3.60e-07	1014	133	17	32416067
Pubmed	Human transcription factor protein interaction networks.	HSPG2 TSHZ3 RAD18 TCF20 E2F3 POGZ LARP4 DCAF5 KANSL3 KMT2C NCOR2 MAP7D1 KMT2D YAF2 ZNF592 ZSCAN18 KMT2A PRKCSH SRRM2 ZNF687	5.40e-07	1429	133	20	35140242
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	RAD18 SALL3 TCF20 MAP4 NSD1 POGZ RRBP1 CHAMP1 PRAM1 NCOR2 EPS15L1 PHF3 KMT2A SRRM2 HDGFL2 RAI1	8.13e-07	954	133	16	36373674
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SHROOM3 MAP4 ARHGAP10 NSD1 CHD2 BRD3 SCAF1 USP10 KMT2C MAP7D1 UBXN4 ZNF592 PHF3 FARP1 KMT2A CRYBG1 EIF2A AKAP1 HDGFL2 ZNF687	1.11e-06	1497	133	20	31527615
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	SPHK2 AVL9 CHAMP1 MICALL1 USP10 MAP7D1 PHF3 KMT2A RAI1	1.47e-06	281	133	9	24163370
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	FAM193B INPPL1 RRBP1 ADD1 HELB NHSL1 FAM193A TNKS1BP1	1.53e-06	209	133	8	36779422
Pubmed	Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.	KMT2C KMT2D KMT2A	1.89e-06	7	133	3	36598580
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SPEG RRBP1 KANSL3 NHSL1 SSH1 STARD9 ZNF687	2.17e-06	153	133	7	10718198
Pubmed	Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders.	TCF20 CHAMP1 RAI1	3.02e-06	8	133	3	35074918
Pubmed	Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.	KMT2C KMT2D KMT2A	3.02e-06	8	133	3	23130995
Pubmed	The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.	KMT2C KMT2D KMT2A	3.02e-06	8	133	3	22266653
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	TCF20 CHD2 BRD3 POGZ RRBP1 CHAMP1 KMT2A PRKCSH RAI1 ZNF687	3.05e-06	394	133	10	27248496
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RAD18 MAP4 RRBP1 CHAMP1 USP10 EPS15L1 NFATC2IP PHF3 TNKS1BP1 SRRM2 ZNF687	4.01e-06	503	133	11	16964243
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	AVEN MAP4 POGZ RRBP1 LARP4 ADD1 MICALL1 USP10 MAP7D1 FAM193A PHF3 FARP1 EIF2A	4.49e-06	724	133	13	36232890
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SHROOM3 TCF20 NSD1 GRM1 ADD1 USP10 NCOR2 EPS15L1 MAP7D1 SSH1 FARP1 ZSCAN18 FRMPD3 SLC4A4 RAI1	4.50e-06	963	133	15	28671696
Pubmed	Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.	KMT2C KMT2D KMT2A	4.52e-06	9	133	3	22665483
Pubmed	Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.	E2F3 KMT2D KMT2A	4.52e-06	9	133	3	16951254
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	PCLO CCKBR AFAP1L2 PKD1 CACNA1H GNAS MYO16	4.54e-06	171	133	7	20201926
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TSHZ3 SHROOM3 INPPL1 PTPN22 DTNBP1 GRM1 TGFB1I1 NCOR2 ZNF469 FAM193A	6.57e-06	430	133	10	35044719
Pubmed	Identification of proximal SUMO-dependent interactors using SUMO-ID.	MAP4 MCM10 LARP4 PAPOLG KANSL3 USP10 NCOR2 EPS15L1 PHF3 TNKS1BP1	8.68e-06	444	133	10	34795231
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	TCF20 CHAMP1 KANSL3 KMT2D NFATC2IP PHF3 KMT2A RAI1	9.56e-06	268	133	8	33640491
Pubmed	Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.	KMT2C KMT2D KMT2A	1.17e-05	12	133	3	27563068
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	SHROOM3 MAP4 CARMIL1 INPPL1 ADD1 MICALL1 NHSL1 EPS15L1 CRYBG1 TNKS1BP1 EIF2A	1.20e-05	565	133	11	25468996
Pubmed	Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.	TCF20 POGZ NCOR2 KMT2D RAI1	1.28e-05	78	133	5	28611094
Pubmed	Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.	KMT2C KMT2D	1.45e-05	2	133	2	28483418
Pubmed	Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.	SIRT6 ULK1	1.45e-05	2	133	2	28653878
Pubmed	Cav3.2 subunit underlies the functional T-type Ca2+ channel in murine hearts during the embryonic period.	CACNA1H CACNA1G	1.45e-05	2	133	2	14988077
Pubmed	Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice.	CACNA1H CACNA1G	1.45e-05	2	133	2	21622683
Pubmed	The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.	KMT2C KMT2D	1.45e-05	2	133	2	34156443
Pubmed	Mutations in RAI1 associated with Smith-Magenis syndrome.	TCF20 RAI1	1.45e-05	2	133	2	12652298
Pubmed	Ca(v)3.2 T-type Ca2+ channel-dependent activation of ERK in paraventricular thalamus modulates acid-induced chronic muscle pain.	CACNA1H CACNA1G	1.45e-05	2	133	2	20685979
Pubmed	Rad18 is a transcriptional target of E2F3.	RAD18 E2F3	1.45e-05	2	133	2	22391204
Pubmed	KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.	KMT2C KMT2D	1.45e-05	2	133	2	31924266
Pubmed	Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus.	ADD1 FAM193A	1.45e-05	2	133	2	8946164
Pubmed	Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.	KMT2C KMT2D	1.45e-05	2	133	2	27280393
Pubmed	T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells.	CACNA1H CACNA1G	1.45e-05	2	133	2	22469755
Pubmed	Activity-dependent gating of calcium spikes by A-type K+ channels controls climbing fiber signaling in Purkinje cell dendrites.	GRM1 CACNA1G	1.45e-05	2	133	2	25220810
Pubmed	Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.	KMT2C KMT2D	1.45e-05	2	133	2	36869380
Pubmed	Chronic deficit in nitric oxide elicits oxidative stress and augments T-type calcium-channel contribution to vascular tone of rodent arteries and arterioles.	CACNA1H CACNA1G	1.45e-05	2	133	2	23436820
Pubmed	Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.	KMT2D KMT2A	1.45e-05	2	133	2	26711341
Pubmed	Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type Ca(2+) channels in the embryonic heart of mice.	CACNA1H CACNA1G	1.45e-05	2	133	2	21079360
Pubmed	Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.	KMT2C KMT2D	1.45e-05	2	133	2	28967912
Pubmed	Deficiency of T-type Ca2+ channels Cav3.1 and Cav3.2 has no effect on angiotensin II-induced hypertension but differential effect on plasma aldosterone in mice.	CACNA1H CACNA1G	1.45e-05	2	133	2	31042060
Pubmed	LYP regulates SLP76 and other adaptor proteins in T cells.	PTPN22 LCP2	1.45e-05	2	133	2	39342392
Pubmed	The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice.	CACNA1H CACNA1G	1.45e-05	2	133	2	22886848
Pubmed	Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.	KMT2D KMT2A	1.45e-05	2	133	2	24423662
Pubmed	A phylogenetic study of SPBP and RAI1: evolutionary conservation of chromatin binding modules.	TCF20 RAI1	1.45e-05	2	133	2	24205348
Pubmed	Deletion of T-type calcium channels Cav3.1 or Cav3.2 attenuates endothelial dysfunction in aging mice.	CACNA1H CACNA1G	1.45e-05	2	133	2	29082441
Pubmed	Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.	KMT2C KMT2D	1.45e-05	2	133	2	25346535
Pubmed	[Decreased mRNA expressions of T-type channel alpha1H and alpha1G in the sperm of varicocele patients and their implication].	CACNA1H CACNA1G	1.45e-05	2	133	2	22574369
Pubmed	Ubiquitin-Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6.	SIRT6 USP10	1.45e-05	2	133	2	29698567
Pubmed	A case of pediatric acute myeloid leukemia with t(11;16)(q23;q24) leading to a novel KMT2A-USP10 fusion gene.	USP10 KMT2A	1.45e-05	2	133	2	30107050
Pubmed	Blockade of T-type Ca(2+) channels inhibits human ovarian cancer cell proliferation.	CACNA1H CACNA1G	1.45e-05	2	133	2	21438841
Pubmed	Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.	LCP2 PRAM1	1.45e-05	2	133	2	24034616
Pubmed	Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.	KMT2C KMT2D	1.45e-05	2	133	2	36601880
Pubmed	β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A.	CACNA1H CACNA1G	1.45e-05	2	133	2	22808078
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	FAM193B MAP4 CARMIL1 RRBP1 CHAMP1 ADD1 USP10 EPS15L1 FAM193A KMT2A TNKS1BP1 EIF2A AKAP1 HDGFL2	1.47e-05	934	133	14	33916271
Pubmed	Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.	AVL9 UBXN4 ZNF592 PHF3 LPIN2	1.73e-05	83	133	5	9039502
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	TCF20 NSD1 POGZ NCOR2 KMT2D	1.73e-05	83	133	5	28794006
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RAD18 ERCC5 SALL3 MAP4 NSD1 CHD2 COLGALT1 GALNT7 ANKRD6 CDCP1 DCAF5 KMT2C FARP1 CRYBG1 CIPC	1.82e-05	1084	133	15	11544199
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	E2F3 POGZ CHAMP1 HELB KANSL3 KMT2C KMT2D YAF2 CBX6 KMT2A	2.21e-05	495	133	10	27705803
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TCF20 MAP4 PTPN22 POGZ KANSL3 PRAM1 KMT2C NCOR2 MAP7D1 KMT2D KMT2A EIF2A SRRM2 RAI1 ZNF687	2.23e-05	1103	133	15	34189442
Pubmed	Impact of WIN site inhibitor on the WDR5 interactome.	HELB KMT2C KMT2D KMT2A	2.25e-05	43	133	4	33472061
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TSHZ3 TCF20 PCLO BRD3 POGZ KMT2C NCOR2 KMT2D MGME1	2.40e-05	398	133	9	35016035
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TCF20 MCM10 RRBP1 LARP4 ADD1 PAPOLG UBXN4 FAM193A GLE1 PHF3 AKAP1 ZNF687	2.64e-05	733	133	12	34672954
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	PCLO CHD2 BRD3 TGFB1I1 SCAF1 KMT2C AFAP1L2 ZNF592 PKD1 PITPNM3 TMEM200C RAI1	2.75e-05	736	133	12	29676528
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DENND2A MAP4 CARMIL1 PCLO RRBP1 GRM1 ADD1 NHSL1 USP10 MLXIPL EPS15L1 MAP7D1 FARP1 KMT2A PACS2 TNKS1BP1 SLC4A4	3.42e-05	1431	133	17	37142655
Pubmed	The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse.	PKD1 PRKCSH SLC4A4	3.57e-05	17	133	3	16472605
Pubmed	5,6-EET potently inhibits T-type calcium channels: implication in the regulation of the vascular tone.	CACNA1H CACNA1G	4.34e-05	3	133	2	24327205
Pubmed	Novel analytical methods to interpret large sequencing data from small sample sizes.	ERCC5 PTPN22	4.34e-05	3	133	2	31470908
Pubmed	Role of CircCHD2 in the pathogenesis of gestational diabetes mellitus by regulating autophagy via miR-33b-3p/ULK1 axis.	CHD2 ULK1	4.34e-05	3	133	2	38039841
Pubmed	Ethanol inhibition of a T-type Ca²+ channel through activity of protein kinase C.	CACNA1H CACNA1G	4.34e-05	3	133	2	23488970
Pubmed	Differential effect of T-type voltage-gated Ca2+ channel disruption on renal plasma flow and glomerular filtration rate in vivo.	CACNA1H CACNA1G	4.34e-05	3	133	2	24966091
Pubmed	T-type channels: release a brake, engage a gear.	CACNA1H CACNA1G	4.34e-05	3	133	2	26488564
Pubmed	Differential interactions of Na+ channel toxins with T-type Ca2+ channels.	CACNA1H CACNA1G	4.34e-05	3	133	2	18591418
Pubmed	Identification of the t-type calcium channel (Ca(v)3.1d) in developing mouse heart.	CACNA1H CACNA1G	4.34e-05	3	133	2	11230107
Pubmed	Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.	CACNA1H CACNA1G	4.34e-05	3	133	2	28846697
Pubmed	Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.	KMT2A HDGFL2	4.34e-05	3	133	2	33477970
Pubmed	Caveolin-3 regulates protein kinase A modulation of the Ca(V)3.2 (alpha1H) T-type Ca2+ channels.	CACNA1H CACNA1G	4.34e-05	3	133	2	21084288
Pubmed	Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.	KMT2D KMT2A	4.34e-05	3	133	2	26902498
Interaction	TOP3B interactions	HSPG2 FAM193B SPHK2 SHROOM3 KIF26A SPEG INPPL1 TSNARE1 NSD1 SFI1 LARP4 MICALL1 PPP1R26 KANSL3 HIVEP3 NHSL1 SCAF1 USP10 KMT2C NCOR2 EPS15L1 KMT2D SSH1 ZNF592 PKD1 OSBPL5 RIPOR1 ZFYVE26 CACNA1H TNKS1BP1 ULK1 GNAS EIF2A RAI1 ZNF687	1.47e-11	1470	133	35	int:TOP3B
Interaction	H3-3A interactions	TSHZ3 RAD18 TCF20 NSD1 E2F3 CHD2 BRD3 POGZ MCM10 CHAMP1 PAPOLG KMT2C KMT2D NFATC2IP ZNF592 CBX6 PHF3 OSBPL5 ZSCAN18 KMT2A HDGFL2 RAI1	3.95e-09	749	133	22	int:H3-3A
Interaction	TERF2IP interactions	RAD18 ERCC5 TCF20 NSD1 POGZ MCM10 CHAMP1 KANSL3 NCOR2 NFATC2IP ZNF592 PHF3 ZSCAN18 KMT2A SRRM2 RAI1 ZNF687	1.40e-07	552	133	17	int:TERF2IP
Interaction	NUP43 interactions	ERCC5 TCF20 MAP4 NSD1 POGZ SIRT6 CHAMP1 HELB KANSL3 SCAF1 NCOR2 KMT2D NFATC2IP ZNF592 KMT2A EIF2A SRRM2 ZNF687	1.59e-07	625	133	18	int:NUP43
Interaction	FBXO22 interactions	SPEG CARMIL1 PTPN22 CHD2 BRD3 RRBP1 LCP2 KMT2C NCOR2 MAP7D1 ZNF592 KMT2A HDGFL2 RAI1 ZNF687	2.88e-06	540	133	15	int:FBXO22
Interaction	ASF1A interactions	TCF20 NSD1 POGZ NCOR2 KMT2D ZNF592 PHF3 KMT2A RAI1 ZNF687	6.18e-06	249	133	10	int:ASF1A
Interaction	H2BC8 interactions	RAD18 ERCC5 TCF20 NSD1 BRD3 POGZ MCM10 CHAMP1 NFATC2IP ZNF592 PHF3 KMT2A HDGFL2 RAI1 ZNF687	6.29e-06	576	133	15	int:H2BC8
Interaction	EN1 interactions	DCAF5 KMT2C NCOR2 KMT2D YAF2 KMT2A SRRM2	8.42e-06	110	133	7	int:EN1
Interaction	APEX1 interactions	RAD18 ERCC5 TCF20 NSD1 BMERB1 BRD3 POGZ SIRT6 LARP4 CHAMP1 TGFB1I1 EPS15L1 MAP7D1 FAM193A PHF3 PKD1 ZSCAN18 OSBPL7 KMT2A EIF2A SPOCD1 HDGFL2 RAI1	9.14e-06	1271	133	23	int:APEX1
Interaction	CBX3 interactions	RAD18 TCF20 NSD1 BRD3 POGZ SIRT6 CHAMP1 YAF2 NFATC2IP CBX6 PHF3 KMT2A TNKS1BP1 SRRM2 HDGFL2	2.43e-05	646	133	15	int:CBX3
Interaction	H3C3 interactions	TSHZ3 RAD18 TCF20 NSD1 BRD3 POGZ CHAMP1 NFATC2IP PHF3 ZSCAN18 KMT2A HDGFL2 RAI1	2.48e-05	495	133	13	int:H3C3
Interaction	YWHAH interactions	SHROOM3 TCF20 SPEG RPS6KA1 CARMIL1 INPPL1 MICALL1 NHSL1 MLXIPL MAP7D1 YAF2 SSH1 PHF3 STARD9 OSBPL5 KMT2A PACS2 TNKS1BP1 SRRM2 AKAP1	3.63e-05	1102	133	20	int:YWHAH
Interaction	CENPA interactions	TSHZ3 RAD18 ERCC5 TCF20 NSD1 BRD3 MCM10 NFATC2IP KMT2A HDGFL2 RAI1	4.17e-05	377	133	11	int:CENPA
Interaction	CHD4 interactions	TSHZ3 RAD18 SALL3 TCF20 STMN2 BRD3 POGZ SIRT6 RRBP1 CHAMP1 MLXIPL ZNF592 KMT2A PRKCSH SRRM2 HDGFL2 RAI1 ZNF687	4.54e-05	938	133	18	int:CHD4
Interaction	H3C1 interactions	SPHK2 RAD18 ARHGAP10 NSD1 E2F3 BRD3 POGZ SIRT6 RRBP1 CHAMP1 KMT2C MAP7D1 KMT2D CBX6 PHF3 KMT2A HDGFL2	9.23e-05	901	133	17	int:H3C1
Interaction	ARHGAP28 interactions	ARHGAP10 ARHGAP30 ARHGAP22	9.70e-05	14	133	3	int:ARHGAP28
Interaction	TBXT interactions	TCF20 POGZ KMT2C NCOR2 KMT2D YAF2	1.21e-04	116	133	6	int:TBXT
Interaction	H2AC4 interactions	RAD18 TCF20 CHD2 POGZ SIRT6 PPP1R26 KMT2C KMT2D CBX6 KMT2A RAI1 ZNF687	1.35e-04	506	133	12	int:H2AC4
Interaction	SETD1A interactions	RAD18 ARHGAP10 SIRT6 KANSL3 KMT2C KMT2D KMT2A	1.37e-04	170	133	7	int:SETD1A
Interaction	SETD1B interactions	SIRT6 KANSL3 KMT2C KMT2D KMT2A	1.38e-04	75	133	5	int:SETD1B
Interaction	PCGF6 interactions	RAD18 E2F3 POGZ CHAMP1 KANSL3 YAF2 CBX6	1.42e-04	171	133	7	int:PCGF6
Interaction	PLCD3 interactions	RAD18 BRD3 DCAF5 ARHGAP22 GPR156 HDGFL2	1.52e-04	121	133	6	int:PLCD3
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	NSD1 KMT2C KMT2D KMT2A	2.08e-05	34	87	4	487
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	SFI1 GRM1 PPP1R26 FARP1 SPOCD1 AKAP1 MYO16	2.67e-05	181	87	7	694
GeneFamily	PHD finger proteins	NSD1 KMT2C KMT2D PHF3 KMT2A	7.32e-05	90	87	5	88
GeneFamily	SH2 domain containing	INPPL1 SH2D3A LCP2 SHF	1.43e-03	101	87	4	741
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL5 OSBPL7	1.46e-03	12	87	2	670
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP10 ARHGAP30 ARHGAP22	1.79e-03	50	87	3	721
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 ZFHX2	2.31e-03	15	87	2	529
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGAP22 AFAP1L2 FARP1 OSBPL5 OSBPL7	3.17e-03	206	87	5	682
GeneFamily	Ataxins\|Trinucleotide repeat containing	NCOR2 KMT2D	6.39e-03	25	87	2	775
GeneFamily	Calcium voltage-gated channel subunits	CACNA1H CACNA1G	6.90e-03	26	87	2	253
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	TSHZ3 SALL3 CHAMP1 HIVEP3 ZNF469 ZNF592 ZNF358 ZSCAN18 ZFHX2	7.58e-03	718	87	9	28
Coexpression	GSE15215_CD2_POS_VS_NEG_PDC_UP	DENND2A TCF20 MAP4 ARHGAP10 CLASRP HIVEP3 MLXIPL CBX6 LPIN2	7.14e-07	195	133	9	M3519
Coexpression	GSE9988_LPS_VS_VEHICLE_TREATED_MONOCYTE_DN	TCF20 RPS6KA1 ARHGAP30 BRD3 CHAMP1 ARHGAP22 NCOR2 MAP7D1	8.05e-06	198	133	8	M5861
Coexpression	GSE9988_ANTI_TREM1_VS_CTRL_TREATED_MONOCYTES_DN	TCF20 RPS6KA1 BRD3 CHAMP1 DCAF5 MAP7D1 GLE1 KMT2A	8.66e-06	200	133	8	M5851
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_345_5P_GENES	SPEG BRD3 NCOR2 OSBPL5 CIPC	5.53e-05	80	133	5	MM17502
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_28DY_DN	SPHK2 PRAM1 MAP7D1 NFATC2IP CBX6 HPS4 ZSCAN18 OSBPL7 NSUN5P2 RIPOR1 ZFYVE26 PRKCSH ULK1 SRRM2 RAI1	5.77e-05	905	133	15	M40865
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	NSD1 PTPN22 ARHGAP30 CHD2 LCP2 DCAF5 ADD1 PAPOLG HIVEP3 KMT2C MAP7D1 KMT2D UBXN4 SSH1 NFATC2IP PHF3 LPIN2 KMT2A CRYBG1 GNAS	6.46e-05	1492	133	20	M40023
Coexpression	GSE9988_ANTI_TREM1_VS_VEHICLE_TREATED_MONOCYTES_DN	TCF20 RPS6KA1 ARHGAP30 BRD3 ARHGAP22 MAP7D1 ULK1	6.82e-05	197	133	7	M5853
Coexpression	GSE18281_SUBCAPSULAR_CORTICAL_REGION_VS_WHOLE_MEDULLA_THYMUS_UP	HSPG2 TCF20 STMN2 NSD1 BMERB1 ADD1 SRRM2	7.26e-05	199	133	7	M7254
Coexpression	GSE17721_LPS_VS_PAM3CSK4_1H_BMDC_DN	XIRP1 CLASRP NHSL1 USP10 UBXN4 CACNA1H SLC41A1	7.26e-05	199	133	7	M3912
Coexpression	GSE23984_CTRL_VS_HYPOCALEMIC_VITAMIND_ANALOG_TCELL_DN	SFI1 DTNBP1 HIVEP3 ZNF469 UBXN4 KMT2A SRRM2	7.49e-05	200	133	7	M8052
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_GERMINAL_CENTER_BCELL_DAY7_UP	TSHZ3 RPS6KA1 ADD1 MAP7D1 YAF2 CRYBG1 RAI1	7.49e-05	200	133	7	M9319
Coexpression	GSE20198_IL12_IL18_VS_IFNA_TREATED_ACT_CD4_TCELL_UP	HELB PAPOLG HIVEP3 ARHGAP22 SCAF1 OSBPL7 PRKCSH	7.49e-05	200	133	7	M7370
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR2 PCLO MCM10 CDCP1 ANKRD53 SCAF1 MLXIPL PITPNM3 ZFHX2 GPR151	1.29e-10	174	133	10	f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO STMN2 GRM1 SHF PITPNM3 CACNA1G FRMPD3	1.89e-06	193	133	7	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SPEG CHD2 SFI1 HELB KANSL3 CRYBG1	9.34e-06	162	133	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ELAPOR2 SHROOM3 RRBP1 CDCP1 SLC4A4 AKAP1	1.92e-05	184	133	6	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SALL3 AVL9 KANSL3 HIVEP3 MUC6	1.98e-05	185	133	6	bdd2e6cb20294b39a9d856004bf57ba69cf877e2
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSHZ3 KIF26A STMN2 TGFB1I1 AFAP1L2 FAM181B	2.11e-05	187	133	6	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO STMN2 GRM1 SHF PITPNM3 FRMPD3	2.24e-05	189	133	6	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TSHZ3 STMN2 TGFB1I1 CBX6 CACNA1H SPOCD1	2.30e-05	190	133	6	591310e615700321a010a4b90405cbbbbdb3aade
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND2A ARHGAP10 TGFB1I1 AFAP1L2 STARD9 CACNA1H	2.37e-05	191	133	6	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DENND2A ARHGAP10 TGFB1I1 AFAP1L2 STARD9 CACNA1H	2.37e-05	191	133	6	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	CHD2 SFI1 HELB KMT2C KMT2A CRYBG1	2.44e-05	192	133	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DENND2A SHROOM3 SHF GNAS FAM181B SLC4A4	2.59e-05	194	133	6	8b81f039f5b25d35a4d5a41b27d4d9360ba22f15
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO NSD1 KMT2C MLXIPL KMT2A SRRM2	2.67e-05	195	133	6	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A ARHGAP10 AFAP1L2 STARD9 CIPC CACNA1H	2.82e-05	197	133	6	f66945f9007d59d4208849c7fd727f8519713fbc
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DENND2A ARHGAP10 AFAP1L2 STARD9 CIPC CACNA1H	2.82e-05	197	133	6	41dd312f46a2b983c8d864adeb6970c0ca4a8048
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB1I1 CBX6 GLE1 STARD9 FARP1 PACS2	2.82e-05	197	133	6	789c97ca9d1e28df3353140046047f11fbccc1d0
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	SHROOM3 PCLO GALNT7 UBXN4 PHF3 LPIN2	2.99e-05	199	133	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3---L2-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 ARHGAP10 ZNF469 IQCJ IQCJ-SCHIP1 SLC4A4	3.07e-05	200	133	6	9c89e91bb630cc306a820927a36ea6fb3d13e9d7
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 ARHGAP10 ZNF469 IQCJ IQCJ-SCHIP1 SLC4A4	3.07e-05	200	133	6	8821574d17b55dfea3ca0204e6b4c0ca6b19588a
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3--\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 ARHGAP10 ZNF469 IQCJ IQCJ-SCHIP1 SLC4A4	3.07e-05	200	133	6	96b1d2e70fbbba744fd4356a70efcf356aca9abc
ToppCell	LPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2\|LPS_only / Treatment groups by lineage, cell group, cell type	DENND2A TSHZ3 TGFB1I1 AFAP1L2 STARD9 SLC4A4	3.07e-05	200	133	6	69edc375d85689300d1dbc1217fedc40063ecdcb
ToppCell	Neuronal-Excitatory-eA(LAMP5_LINC00507)-FREM3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SHROOM3 ARHGAP10 ZNF469 IQCJ IQCJ-SCHIP1 SLC4A4	3.07e-05	200	133	6	ad6f1d4d7f5d7bab2ba2e4fff58c535290065c0e
ToppCell	356C-Fibroblasts-Fibroblast-E\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FAM193B INPPL1 ZNF592 HPS4 CIPC	5.52e-05	136	133	5	edfd453c9a650d69d05a5a3ab15f7df56349fa86
ToppCell	356C-Fibroblasts-Fibroblast-E-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	FAM193B INPPL1 ZNF592 HPS4 CIPC	5.52e-05	136	133	5	03e4e2353c23ceffde35b2d0aadd15299e3db09f
Disease	Intellectual Disability	TCF20 NSD1 E2F3 POGZ CHAMP1 KMT2C PACS2 CACNA1G GNAS EIF2A RAI1	5.71e-06	447	132	11	C3714756
Disease	Kleefstra syndrome 2 (implicated_via_orthology)	KMT2C KMT2D	1.99e-05	2	132	2	DOID:0080598 (implicated_via_orthology)
Disease	hypertrophic cardiomyopathy	KMT2C ZNF592 PKD1 TNKS1BP1 MUC6	5.98e-05	92	132	5	EFO_0000538
Disease	Neurodevelopmental Disorders	CHD2 POGZ HIVEP3 KMT2C KMT2A	6.29e-05	93	132	5	C1535926
Disease	event-related brain oscillation	KANSL3 GNAS	1.18e-04	4	132	2	EFO_0004358
Disease	Weaver syndrome	NSD1 KMT2A	1.97e-04	5	132	2	C0265210
Disease	Polycystic Kidney - body part	PKD1 PRKCSH	1.97e-04	5	132	2	C1567435
Disease	cognitive function measurement	SEC16B TCF20 MAP4 TSNARE1 CHD2 BRD3 C8orf34 ARHGAP22 KMT2D FAM193A NFATC2IP IQCJ FARP1 CRYBG1 CACNA1H IQCJ-SCHIP1 TMEM200C	2.32e-04	1434	132	17	EFO_0008354
Disease	Sezary Syndrome	RPS6KA1 KMT2C KMT2D	2.37e-04	27	132	3	C0036920
Disease	Polycystic Kidney Diseases	PKD1 PRKCSH	2.94e-04	6	132	2	C0022680
Disease	neuroimaging measurement	SHROOM3 CARMIL1 LARP4 NHSL1 ARHGAP22 MLXIPL ZNF469 IQCJ PKD1 IQCJ-SCHIP1 PRKCSH SLC41A1 MYO16 RAI1	3.19e-04	1069	132	14	EFO_0004346
Disease	temporal lobe epilepsy (biomarker_via_orthology)	DTNBP1 GRM1 ADD1	3.59e-04	31	132	3	DOID:3328 (biomarker_via_orthology)
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 PRKCSH	4.11e-04	7	132	2	DOID:0050770 (implicated_via_orthology)
Disease	peptic ulcer disease	CCKBR GNAS MUC6	4.33e-04	33	132	3	MONDO_0004247
Disease	triglyceride change measurement, response to long-chain n-3 PUFA dietary supplementation	IQCJ IQCJ-SCHIP1	5.46e-04	8	132	2	EFO_0007681, EFO_0009308
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	PKD1 PRKCSH	5.46e-04	8	132	2	C0887850
Disease	duodenal ulcer	CCKBR PRKCSH GNAS	5.61e-04	36	132	3	EFO_0004607
Disease	Liver Diseases, Parasitic	KMT2C GNAS	7.00e-04	9	132	2	C0023897
Disease	Hermanski-Pudlak Syndrome	DTNBP1 HPS4	8.73e-04	10	132	2	C0079504
Disease	Hermansky-Pudlak syndrome	DTNBP1 HPS4	8.73e-04	10	132	2	cv:C0079504
Disease	interleukin-6 measurement, response to stimulus	ELAPOR2 CARMIL1	1.06e-03	11	132	2	EFO_0004810, GO_0050896
Disease	dimethylglycine measurement	RAD18 ERCC5 CACNA1G	1.15e-03	46	132	3	EFO_0010476
Disease	intracranial aneurysm (is_implicated_in)	KMT2D PKD1	1.27e-03	12	132	2	DOID:10941 (is_implicated_in)
Disease	coffee consumption measurement	SEC16B ADD1 NCOR2 MLXIPL RAI1	1.39e-03	182	132	5	EFO_0006781
Disease	Respiratory Depression	SLC23A1 MGME1	1.50e-03	13	132	2	C0235063
Disease	Respiratory Insufficiency	SLC23A1 MGME1	1.50e-03	13	132	2	C0035229
Disease	Respiratory Failure	SLC23A1 MGME1	1.50e-03	13	132	2	C1145670
Disease	Connective Tissue Diseases	ZNF469 PKD1	1.50e-03	13	132	2	C0009782
Disease	immature platelet fraction	CARMIL1 BRD3 DCAF5 GNAS	1.75e-03	114	132	4	EFO_0009187
Disease	platelet storage pool deficiency (implicated_via_orthology)	DTNBP1 HPS4	2.01e-03	15	132	2	DOID:2223 (implicated_via_orthology)
Disease	alkaline phosphatase measurement	SEC16B HSPG2 MAP4 ARHGAP10 CARMIL1 PTPN22 RRBP1 DTNBP1 HIVEP3 MLXIPL PKD1 RAI1	2.05e-03	1015	132	12	EFO_0004533
Disease	platelet component distribution width	DENND2A CARMIL1 RIPOR3 BRD3 DCAF5 MICALL1 NCOR2 MLXIPL AFAP1L2 GNAS	2.15e-03	755	132	10	EFO_0007984
Disease	monocyte count	CARMIL1 RIPOR3 HBP1 PTPN22 ARHGAP30 HIVEP3 NCOR2 MLXIPL MRAP PKD1 GPR156 SLC41A1 MYO16 RAI1	2.41e-03	1320	132	14	EFO_0005091
Disease	electrocardiography	SPEG CARMIL1 E2F3 JSRP1 ZNF592 ZNF358 CACNA1G SLC41A1	2.71e-03	530	132	8	EFO_0004327
Disease	Tourette syndrome, schizophrenia	TCF20 PHF3	2.90e-03	18	132	2	EFO_0004895, MONDO_0005090
Disease	cholangiocarcinoma (is_marker_for)	OSBPL7 SLC4A4 MUC6	2.99e-03	64	132	3	DOID:4947 (is_marker_for)
Disease	C-reactive protein measurement	SEC16B ARHGAP10 RPS6KA1 CARMIL1 TSNARE1 RIPOR3 BRD3 CLASRP MLXIPL ZNF469 CBX6 PKD1 TNKS1BP1	2.99e-03	1206	132	13	EFO_0004458
Disease	depressive symptom measurement	TCF20 CARMIL1 TSNARE1 PCLO DCAF5 FARP1 KMT2A	3.13e-03	426	132	7	EFO_0007006
Disease	cerebral microbleeds	HSPG2 OSBPL5	3.23e-03	19	132	2	EFO_0010059
Disease	pelvic organ prolapse	PAPOLG IQCJ FARP1 IQCJ-SCHIP1	3.31e-03	136	132	4	EFO_0004710
Disease	Profound Mental Retardation	NSD1 CACNA1G GNAS RAI1	3.58e-03	139	132	4	C0020796
Disease	lung non-small cell carcinoma (is_implicated_in)	ERCC5 E2F3 KMT2C KMT2D	3.58e-03	139	132	4	DOID:3908 (is_implicated_in)
Disease	Mental Retardation, Psychosocial	NSD1 CACNA1G GNAS RAI1	3.58e-03	139	132	4	C0025363
Disease	Mental deficiency	NSD1 CACNA1G GNAS RAI1	3.58e-03	139	132	4	C0917816
Disease	ulcerative colitis, Crohn's disease	PTPN22 NCOR2	3.58e-03	20	132	2	EFO_0000384, EFO_0000729
Disease	congenital heart disease (implicated_via_orthology)	KMT2C KMT2D KMT2A	3.70e-03	69	132	3	DOID:1682 (implicated_via_orthology)
Disease	white matter lesion progression measurement	GLE1 IQCJ IQCJ-SCHIP1	4.01e-03	71	132	3	EFO_0007746
Disease	Sclerocystic Ovaries	ARHGAP30 LARP4 JSRP1 GNAS	4.06e-03	144	132	4	C1136382
Disease	Polycystic Ovary Syndrome	ARHGAP30 LARP4 JSRP1 GNAS	4.06e-03	144	132	4	C0032460

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASPKVTRSPPETAAP	BARGIN	551	Q6ZT62
PSLPSKLDPFESSDP	EPS15L1	696	Q9UBC2
ITASRSESPPPLSDP	BRD3	256	Q15059
SPRDKAITPPLPEST	AKAP1	526	Q92667
SLPPESAATSKRAPP	CBX6	316	O95503
SRAPTAKLATEEPPP	CDCP1	781	Q9H5V8
VSPRPKAVTPASAPD	AFAP1L2	766	Q8N4X5
SNISPPSPDSKSLPR	C8orf34	191	Q49A92
PSPDSKSLPRSVEHP	C8orf34	196	Q49A92
PKSPDASSAFSPASP	GLE1	86	Q53GS7
PDEDPPTPSIASLSR	CCKBR	421	P32239
SSEPARRPTEPPKAT	FAM193A	1056	P78312
SRPKVSAFSDPTPPA	ANKRD6	341	Q9Y2G4
SPGDAPKPHRKPSSS	RAI1	1616	Q7Z5J4
SSPKPQTSDRPTDKP	NSD1	2396	Q96L73
SDASPPPVKIESSSP	HSPG2	2046	P98160
DPSEAKRPEPPSTST	RAD18	181	Q9NS91
PLGKRSPSPPSVSSE	IQCJ	66	Q1A5X6
SPKSELHQDRSSPPP	PTPN22	681	Q9Y2R2
ASLTPPRADPSPSKE	ANKRD53	81	Q8N9V6
PPATVADKPPESIRS	ARHGAP10	716	A1A4S6
SSKPTASSGEPPRPT	MUC6	1261	Q6W4X9
LEPASSPSKGSEPRP	NCOR2	1966	Q9Y618
EPVAPKATAPPERTS	PIERCE1	11	Q5BN46
PEPFPATSKERPRSL	FAM189A1	466	O60320
KSDNSDIRPSGSPPP	KMT2C	2926	Q8NEZ4
APEKRASPSKPASAP	MAP4	781	P27816
SSAPREPSSPLPKFE	JSRP1	166	Q96MG2
PERSDKPNASDPSVP	MGME1	106	Q9BQP7
SPPSSRPLSSPLDEL	MYO16	1661	Q9Y6X6
RSEALPTDLPAPSAP	PRKCSH	281	P14314
PASSRAEKKAEPPPS	BMERB1	166	Q96MC5
PPEDTAISSLRPPSA	HPS4	416	Q9NQG7
AEARPSPSTTPLPDS	NHSL1	1176	Q5SYE7
ADSLSKPAPPKEPSV	PCLO	726	Q9Y6V0
PNPSELRAKPPSSSS	DTNBP1	286	Q96EV8
KASAPERTPSPAPKR	NSUN5P2	251	Q63ZY6
SSASLPRSPPPTVDE	DCAF5	461	Q96JK2
SASPPPKERSSSPAT	L1RE1	16	Q9UN81
PPAPPTRKSSLEQRS	KIF26A	1361	Q9ULI4
PTPAPRKASESTTPA	MICALL1	301	Q8N3F8
RTPKASPPDPKSSSS	MCM10	191	Q7L590
PSPSAADTPAKRPLA	FAM181B	116	A6NEQ2
EPPSPADVPEKTRSL	PACS2	346	Q86VP3
SASPAAKEASPTPPS	PACS2	711	Q86VP3
PASIPEKEKPSSPSS	GPR151	356	Q8TDV0
PSSSSRPLPPCQEKD	ELAPOR2	51	A8MWY0
KPKPERPPSSSSSDS	HDGFL2	291	Q7Z4V5
LPSKELPDSSSPVPA	PAPOLG	706	Q9BWT3
LRSPDSPKTPKSPSE	E2F3	161	O00716
PSSDSKDPLASGPPD	CACNA1G	2336	O43497
KISPPSTPSSPDDIF	DENND2A	451	Q9ULE3
SPGPSRDSQKPTSPL	AVEN	261	Q9NQS1
DPRSPPSQKSPHDSK	CHD2	1786	O14647
KSEASPAPRPPASLE	FAM193B	726	Q96PV7
PEFLASSPPDNKSPD	FARP1	866	Q9Y4F1
ARTTSPEPRKPSPSE	CHAMP1	271	Q96JM3
TSPRKSSRCTPPPAD	FRMPD3	541	Q5JV73
SSLTPRPDDPSPLSR	GALNT7	26	Q86SF2
LKPPSRPSPDSSESD	AVL9	316	Q8NBF6
PKKPTRRDASPESPS	GNAS	221	O95467
SRPHPSTAESKAPTP	LARP4	461	Q71RC2
SPSSEAKSRGPTPPA	MAP7D1	86	Q3KQU3
EKESAAPASPAPSPA	MAP7D1	536	Q3KQU3
RPSSRKPSLPSDPQD	GPR156	656	Q8NFN8
SRPASPAAKLPASPS	KANSL3	511	Q9P2N6
SQKPTPSAREDPAPK	KMT2A	1241	Q03164
RPPPVSSSSKSEPAF	HBP1	151	O60381
RPDDIPDSPSSPKVA	CARMIL1	1281	Q5VZK9
ESDRSKQPPPASSPT	CRYBG1	91	Q9Y4K1
ARSDKSPDLAPTPAP	EIF2A	501	Q9BY44
PAEPSRFISAPTKTP	COLGALT1	321	Q8NBJ5
DSPALTPPSPFRDSV	GRM1	1141	Q13255
PTPKSSPFLDAAPSL	CACNA1H	1086	O95180
IPLKTERPDSPAAAP	SALL3	931	Q9BXA9
PPADFPSPRKSSGDS	HELB	961	Q8NG08
SRGSKVSPDVPPPSA	PKD1	4166	P98161
RDPPFLPESAQSSKP	OSBPL7	6	Q9BZF2
GPPDEKLEASPASSP	ARHGAP30	471	Q7Z6I6
LPRDEGPPTPSSATK	OSBPL5	56	Q9H0X9
ATPRDKPPVPSSLAS	SFI1	1106	A8K8P3
EASPTRDRSPPKSPE	SRRM2	396	Q9UQ35
SRHASSSPESPKPAP	SRRM2	431	Q9UQ35
SGSDSSPEPKAPAPR	SRRM2	1616	Q9UQ35
DSSPLAKAASPSPPL	TMEM200C	496	A6NKL6
LDSEPSVPSAAKPPS	POGZ	411	Q7Z3K3
TEKEPDATPPSPRTL	ERCC5	331	P28715
SKPSEPPPGDRTSQL	MRAP	156	Q8TCY5
DELSHPARPPSEPKS	PRAM1	171	Q96QH2
GDLPRKPPLPSSASE	PRAM1	376	Q96QH2
KPPLPSSASESSLPA	PRAM1	381	Q96QH2
DEKPPLPPRSGSTSI	INPPL1	136	O15357
RDPHPKATSSPTFEP	SHROOM3	1511	Q8TF72
TDRGPAPPSPLKETS	SLC41A1	81	Q8IVJ1
KETKAPPPASPASRS	PPP1R26	451	Q5T8A7
TPSSADPLAPDSPRS	STARD9	2711	Q9P2P6
PLGKRSPSPPSVSSE	IQCJ-SCHIP1	66	B3KU38
DNSPLSPPSPRTKSR	NFATC2IP	196	Q8NCF5
SEPASPKRERPTSPA	SIRT6	326	Q8N6T7
PKAERLSPPAPSGSE	MLXIPL	596	Q9NP71
PSPLPSSSEDPKSLD	ARHGAP22	551	Q7Z5H3
TPRDPAATSKPSGKP	SSH1	1021	Q8WYL5
TFKPTLPDLSPDEPS	ADD1	636	P35611
SPSTPAPPSAKLAED	CIPC	211	Q9C0C6
SPSPSPAREKLTRPA	CLASRP	531	Q8N2M8
PASPLPEPSLEDSSA	SHF	251	Q7M4L6
PEPTSSPTIGPRKDS	TSNARE1	91	Q96NA8
STPSDPVTKDPPAAS	ZFHX2	31	Q9C0A1
SDSLPTSPPPDDSLS	ZFHX2	701	Q9C0A1
PAPAEPSSDLASKLR	RRBP1	1101	Q9P2E9
RAKSELTLTPDPAPP	SPHK2	396	Q9NRA0
SEAQPSSPARPSAPK	SPEG	2171	Q15772
RPLPPPSSLKASSRE	RIPOR3	596	Q96MK2
TRDPSTPLPTEPKFD	SLC23A1	16	Q9UHI7
PRTSSDPVLLKAPAP	SH2D3A	176	Q9BRG2
TKPPRTPSFELPDAS	SH2D3A	211	Q9BRG2
DKSDPRGPSPAPASS	SCAF1	711	Q9H7N4
SPTLSKEEPPGRPLT	SPOCD1	181	Q6ZMY3
VTRILPDPDDPSKSP	ZNF592	391	Q92610
RLDSPPPSPITEASE	TNKS1BP1	491	Q9C0C2
AKVDSPLPSDKAPTP	TMEM115	316	Q12893
SPTRPKRQPKPSSDE	YAF2	6	Q8IY57
PEPSATPPLDRSSSV	HIVEP3	2341	Q5T1R4
PKDPAALGSSRSSPP	nan	226	A8MX80
QESPKSTFSPAPRPE	PHF3	1176	Q92576
TPPPSSTESKALPAS	TCF20	1671	Q9UGU0
SPPKRATPSPCSSEV	TSHZ3	636	Q63HK5
SSRDSPPLLDAPASP	PITPNM3	491	Q9BZ71
SPESPPLPDVSAFSR	SEC16B	961	Q96JE7
HPKPSARDAPPASSS	ZNF469	1371	Q96JG9
PKDPAVLGSSRSSPP	nan	196	A8MV72
PKDPAALGSSRSSPP	nan	226	Q8N9G6
PKDPAALGSSRSSPP	nan	226	A8MUA0
KAFASPRSSPAPPDL	ZSCAN18	6	Q8TBC5
DLDPTKPESASPPAD	USP10	311	Q14694
SSPKATDIPASASPP	ZNF687	241	Q8N1G0
DPAIRIEPPKSLPSS	SLC4A4	386	Q9Y6R1
PSPISEAPRTLASPK	STMN2	61	Q93045
EDKKRPSLPSSPSPG	TGFB1I1	131	O43294
PPNPASSSKSEKREP	UBXN4	451	Q92575
SSRKPLTSPAPDPSE	RIPOR1	736	Q6ZS17
PETLPRSPSAEFSPA	ZFYVE26	1756	Q68DK2
RLPKPLPLSPSFSSE	XIRP1	1341	Q702N8
PFLDASPSVRKSPPV	ULK1	276	O75385
LPDPSSKPLPGSRST	ZNF358	471	Q9NW07
EESPTSPPPEASRLS	KMT2D	676	O14686
PAPSIDRSTKPPLDR	LCP2	231	Q13094
TSRTPKDSPGIPPSA	RPS6KA1	356	Q15418
APPASDLPSSSKEPA	LPIN2	581	Q92539