Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3C RIMBP3B	3.15e-05	5	36	2	GO:0030156
GeneOntologyCellularComponent	spliceosomal snRNP complex	DDX23 SNRNP70 PRPF3	6.00e-04	96	36	3	GO:0097525
GeneOntologyCellularComponent	small nuclear ribonucleoprotein complex	DDX23 SNRNP70 PRPF3	8.23e-04	107	36	3	GO:0030532
GeneOntologyCellularComponent	manchette	RIMBP3C RIMBP3B	1.06e-03	28	36	2	GO:0002177
GeneOntologyCellularComponent	Sm-like protein family complex	DDX23 SNRNP70 PRPF3	1.12e-03	119	36	3	GO:0120114
Domain	Homeobox_metazoa	HMX1 MNX1 NKX1-2	6.33e-04	90	35	3	IPR020479
Domain	Homeobox_CS	HMX1 MNX1 NKX1-2	5.03e-03	186	35	3	IPR017970
Domain	SH3_9	RIMBP3C RIMBP3B	9.37e-03	78	35	2	PF14604
Domain	Homeobox	HMX1 MNX1 NKX1-2	9.46e-03	234	35	3	PF00046
Domain	HOMEOBOX_1	HMX1 MNX1 NKX1-2	9.68e-03	236	35	3	PS00027
Domain	HOX	HMX1 MNX1 NKX1-2	9.79e-03	237	35	3	SM00389
Domain	Homeobox_dom	HMX1 MNX1 NKX1-2	1.00e-02	239	35	3	IPR001356
Domain	HOMEOBOX_2	HMX1 MNX1 NKX1-2	1.00e-02	239	35	3	PS50071
Domain	SH3_2	RIMBP3C RIMBP3B	1.13e-02	86	35	2	IPR011511
Domain	SH3_2	RIMBP3C RIMBP3B	1.13e-02	86	35	2	PF07653
Domain	-	HMX1 MNX1 NKX1-2	1.58e-02	283	35	3	1.10.10.60
Pathway	BIOCARTA_BARRESTIN_PATHWAY	KCNA3 GNAS	1.39e-04	11	23	2	MM1501
Pathway	BIOCARTA_BARRESTIN_PATHWAY	KCNA3 GNAS	1.66e-04	12	23	2	M7772
Pathway	BIOCARTA_BARR_MAPK_PATHWAY	KCNA3 GNAS	2.29e-04	14	23	2	M668
Pathway	BIOCARTA_BARR_MAPK_PATHWAY	KCNA3 GNAS	2.29e-04	14	23	2	MM1489
Pathway	BIOCARTA_BARRESTIN_SRC_PATHWAY	KCNA3 GNAS	3.41e-04	17	23	2	M111
Pathway	BIOCARTA_BARRESTIN_SRC_PATHWAY	KCNA3 GNAS	3.41e-04	17	23	2	MM1491
Pathway	KEGG_SPLICEOSOME	DDX23 SNRNP70 PRPF3	1.11e-03	127	23	3	M2044
Pubmed	Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.	HMX1 MNX1 NKX1-2	1.55e-06	22	36	3	14645517
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DDX23 EIF3A GNAS SNRNP70 RBM12B PRPF3 TPRN	4.44e-06	660	36	7	32780723
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3C RIMBP3B	6.24e-06	4	36	2	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3C RIMBP3B	1.04e-05	5	36	2	17855024
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	DDX23 CRACD EIF3A GNAS SNRNP70 PRPF3 AP3D1 CLCC1 LEMD2	1.19e-05	1440	36	9	30833792
Pubmed	A novel function for human factor C1 (HCF-1), a host protein required for herpes simplex virus infection, in pre-mRNA splicing.	SNRNP70 PRPF3	2.18e-05	7	36	2	12456665
Pubmed	The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor.	DDX23 PRPF3	2.91e-05	8	36	2	35627203
Pubmed	Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP.	SNRNP70 PRPF3	5.70e-05	11	36	2	21283520
Pubmed	An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.	ITGA7 MNX1	5.70e-05	11	36	2	11988168
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DDX23 EIF3A GNAS RPAP1 SNRNP70 RBM12B PRPF3	7.43e-05	1024	36	7	24711643
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3C RIMBP3B	9.41e-05	14	36	2	17662146
Pubmed	Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.	DDX23 CRACD EIF3A SPG7 SNRNP70 PRPF3	9.61e-05	731	36	6	29298432
Pubmed	SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.	EIF3A SNRNP70 RBM12B CCDC9	1.45e-04	258	36	4	37794589
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	DDX23 EIF3A SNRNP70 RBM12B PRPF3 CCDC9	1.65e-04	807	36	6	22681889
Pubmed	Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.	DDX23 SNRNP70 PRPF3	2.32e-04	115	36	3	17332742
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	DDX23 FKBP15 SNRNP70	3.40e-04	131	36	3	34551306
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	DDX23 EIF3A GNAS PRPF3 AP3D1 TPRN	3.93e-04	949	36	6	36574265
Pubmed	The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.	SPG7 RBM12B	4.45e-04	30	36	2	30480076
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	EIF3A SNRNP70 RBM12B LEMD2	4.56e-04	349	36	4	25665578
Pubmed	Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.	DDX23 PRPF3	4.75e-04	31	36	2	28878014
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	DDX23 PRPF3 FOSL2	4.96e-04	149	36	3	25184681
Pubmed	WW domains provide a platform for the assembly of multiprotein networks.	DDX23 SNRNP70 PRPF3	5.46e-04	154	36	3	16055720
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	RIMBP3C FAT1 TPRN KIAA0753 LEMD2	6.82e-04	689	36	5	36543142
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DDX23 CRYBG3 GNAS RPAP1 AP3D1 CLCC1 KIAA0753	7.23e-04	1487	36	7	33957083
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DDX23 FKBP15 SNRNP70 RBM12B PRPF3 AP3D1	7.83e-04	1082	36	6	38697112
Pubmed	Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.	DDX23 EIF3A RPAP1	7.91e-04	175	36	3	37866880
Pubmed	Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.	DDX23 EIF3A RBM12B PRPF3 AP3D1	8.00e-04	714	36	5	28302793
Pubmed	Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.	EIF3A RPAP1	9.16e-04	43	36	2	34672947
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	DDX23 PRPF3	9.16e-04	43	36	2	26030138
GeneFamily	NKL subclass homeoboxes and pseudogenes	HMX1 NKX1-2	2.98e-03	67	22	2	519
GeneFamily	RNA binding motif containing	SNRNP70 RBM12B	2.73e-02	213	22	2	725
Disease	Head Neoplasms	FAT1 UROD	3.30e-04	24	33	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	FAT1 UROD	3.30e-04	24	33	2	C0887900
Disease	Cancer of Head	FAT1 UROD	3.30e-04	24	33	2	C0751177
Disease	Cancer of Neck	FAT1 UROD	3.58e-04	25	33	2	C0746787
Disease	Neck Neoplasms	FAT1 UROD	3.58e-04	25	33	2	C0027533
Disease	blood vanadium measurement	GNAS HMX1	5.17e-04	30	33	2	EFO_0021533
Disease	Head and Neck Neoplasms	FAT1 UROD	6.27e-04	33	33	2	C0018671
Disease	Malignant Head and Neck Neoplasm	FAT1 UROD	1.11e-03	44	33	2	C0278996

Protein segments in the cluster

Peptide	Gene	Start	Entry
EQERERPVDREPVDR	ASPSCR1	306	Q9BZE9
PRSPSRDKEEEEEER	CRYBG3	21	Q68DQ2
EERRERSPEGPREEE	CLIC6	371	Q96NY7
RPSEADEEELARRRE	AP3D1	656	O14617
ERELPEEEEIPRRRA	CCDC27	386	Q2M243
PEDFRRPREEDFRRP	RBM12B	576	Q8IXT5
RPREEDFRRPSEEDF	RBM12B	581	Q8IXT5
RRSREEDFRHPPDED	RBM12B	796	Q8IXT5
RRQEELAAREEPLEP	RASSF10	361	A6NK89
RGTERREERREPEPH	RIMBP3B	1391	A6NNM3
RGTERREERREPEPH	RIMBP3C	1391	A6NJZ7
PLREEQDLERLRDPE	UROD	111	P06132
EREKPDRERNARREP	FAT1	1256	Q14517
PAPRRARERERERED	NRBP2	6	Q9NSY0
EERPRRCRDELEGPE	LZTS1	296	Q9Y250
DEERLREEARPRGEE	LEMD2	46	Q8NC56
REEARPRGEERLREE	LEMD2	51	Q8NC56
RRLRDLRDSDPEEDE	MNX1	346	P50219
SEEEEEKAEERPRRP	FKBP15	941	Q5T1M5
DPEDEDAEQARRRRL	HMX1	51	Q9NP08
EGFLREEERPLPRRD	KCNA3	201	P22001
PDRERDRDRDRKSSP	DDX23	26	Q9BUQ8
RPRRLGDDEDREPSL	EIF3A	936	Q14152
RPDDDRVPRRGMDDD	EIF3A	951	Q14152
NTDDDRPPRRIADED	EIF3A	991	Q14152
DDRDRRGPPLRSERE	EIF3A	1291	Q14152
RKDDRVEERDPPRRV	EIF3A	1316	Q14152
RSGPLEESERDRREE	CCDC9	201	Q9Y3X0
EPNPLDSEEERRRQE	CRACD	211	Q6ZU35
GRRRRDEQLSPEEEE	FOSL2	111	P15408
DSRDRRRRELEPPEQ	ITGA7	951	Q13683
RRIPRFEEVEEEPEV	PRPF3	111	O43395
SPLPHRDRDRDRERE	SNRNP70	226	P08621
DEGRPLDPEDRAREQ	UVSSA	596	Q2YD98
EEEDAEDPRRPRLRE	NKX1-2	91	Q9UD57
RERAERPPVEEEAAE	GNAS	346	Q5JWF2
RLEEALDPDEERRIR	KIAA0753	241	Q2KHM9
PEEDEEERRRRERDD	SPG7	121	Q9UQ90
PRDRRRQEEIDYRPD	CLCC1	376	Q96S66
RESRLPEDDERPPEE	SHF	186	Q7M4L6
PREELDERIAREEFR	UNC80	2476	Q8N2C7
PEDEDPEERLRRHDQ	RPAP1	86	Q9BWH6
NREPRPREAEEEEAS	TPRN	521	Q4KMQ1