Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

TOP2A TOP2B

8.76e-054772GO:0003918
GeneOntologyMolecularFunctionbiotin binding

ACACA PC

2.18e-046772GO:0009374
GeneOntologyMolecularFunctionligase activity, forming carbon-carbon bonds

ACACA PC

3.04e-047772GO:0016885
GeneOntologyMolecularFunctionDNA topoisomerase activity

TOP2A TOP2B

4.05e-048772GO:0003916
GeneOntologyBiologicalProcesspositive regulation of single stranded viral RNA replication via double stranded DNA intermediate

TOP2A TOP2B

1.34e-052762GO:0045870
GeneOntologyCellularComponentnuclear outer membrane

NAV3 RETSAT TRAPPC2B TRAPPC2

1.41e-0540774GO:0005640
DomainDNA_topoisoIV

TOP2A TOP2B

1.59e-052752PF00521
DomainTopo_IIA_A/C_ab

TOP2A TOP2B

1.59e-052752IPR013758
DomainTopo_IIA_A_a

TOP2A TOP2B

1.59e-052752IPR013757
DomainTopo_IIA_cen_dom

TOP2A TOP2B

1.59e-052752IPR013759
Domain-

TOP2A TOP2B

1.59e-0527523.40.50.670
DomainDTHCT

TOP2A TOP2B

1.59e-052752IPR012542
DomainTOP4c

TOP2A TOP2B

1.59e-052752SM00434
DomainTOP2c

TOP2A TOP2B

1.59e-052752SM00433
DomainTopo_IIA-like_dom

TOP2A TOP2B

1.59e-052752IPR013760
DomainTopo_IIA_bsu_dom2

TOP2A TOP2B

1.59e-052752IPR013506
DomainDTHCT

TOP2A TOP2B

1.59e-052752PF08070
DomainDNA_gyraseB

TOP2A TOP2B

1.59e-052752PF00204
Domain-

TOP2A TOP2B

1.59e-0527521.10.268.10
DomainMethyltransf_2

ASMTL ASMT

1.59e-052752PF00891
DomainTOPRIM_C

TOP2A TOP2B

1.59e-052752IPR031660
DomainTOPRIM_C

TOP2A TOP2B

1.59e-052752PF16898
Domain-

TOP2A TOP2B

1.59e-0527523.90.199.10
DomainTopoIIA_CS

TOP2A TOP2B

1.59e-052752IPR018522
DomainO-MeTrfase_COMT

ASMTL ASMT

1.59e-052752IPR016461
DomainDimerisation2

ASMTL ASMT

1.59e-052752PF16864
DomainO_MeTrfase_2

ASMTL ASMT

1.59e-052752IPR001077
DomainASMT_dimerisation

ASMTL ASMT

1.59e-052752IPR031725
DomainSAM_OMT_II

ASMTL ASMT

1.59e-052752PS51683
DomainTopo_IIA_A/C

TOP2A TOP2B

1.59e-052752IPR002205
DomainTopo_IIA

TOP2A TOP2B

1.59e-052752IPR001241
DomainTOPOISOMERASE_II

TOP2A TOP2B

1.59e-052752PS00177
Domain-

TOP2A TOP2B

4.76e-0537523.30.1360.40
DomainArg_repress_C-like

TOP2A TOP2B

4.76e-053752IPR024946
DomainToprim_domain

TOP2A TOP2B

9.50e-054752IPR006171
DomainToprim

TOP2A TOP2B

9.50e-054752PF01751
DomainTOPRIM

TOP2A TOP2B

9.50e-054752PS50880
DomainBiotin_BS

ACACA PC

1.58e-045752IPR001882
DomainBiotin_carb_C

ACACA PC

1.58e-045752SM00878
DomainBiotin_carb_C

ACACA PC

1.58e-045752PF02785
DomainBiotin_carboxylation_dom

ACACA PC

1.58e-045752IPR011764
DomainBiotin_COase_C

ACACA PC

1.58e-045752IPR005482
DomainBIOTIN

ACACA PC

1.58e-045752PS00188
DomainBC

ACACA PC

1.58e-045752PS50979
DomainRudment_hybrid_motif

ACACA PC

2.36e-046752IPR011054
DomainCPSase_L_D2

ACACA PC

3.30e-047752PF02786
DomainDi19_Zn_binding_dom

ZEB1 ZEB2

3.30e-047752IPR008598
DomainCbamoylP_synth_lsu-like_ATP-bd

ACACA PC

3.30e-047752IPR005479
DomainBC-like_N

ACACA PC

3.30e-047752IPR005481
Domainzf-Di19

ZEB1 ZEB2

3.30e-047752PF05605
DomainBiotin_carb_N

ACACA PC

3.30e-047752PF00289
DomainCullin_Nedd8

CUL3 CUL7

4.39e-048752PF10557
DomainCullin_Nedd8

CUL3 CUL7

4.39e-048752SM00884
DomainCullin_neddylation_domain

CUL3 CUL7

4.39e-048752IPR019559
Domain-

EPM2A PTPRZ1 DUSP16 TNS1

5.13e-04927543.90.190.10
DomainBiotin_lipoyl

ACACA PC

5.62e-049752PF00364
DomainCullin_homology

CUL3 CUL7

5.62e-049752IPR016158
DomainProt-tyrosine_phosphatase-like

EPM2A PTPRZ1 DUSP16 TNS1

6.77e-0499754IPR029021
DomainCullin

CUL3 CUL7

7.01e-0410752PF00888
DomainCULLIN_2

CUL3 CUL7

7.01e-0410752PS50069
DomainBiotin_lipoyl

ACACA PC

7.01e-0410752IPR000089
DomainBIOTINYL_LIPOYL

ACACA PC

7.01e-0410752PS50968
DomainCullin_N

CUL3 CUL7

7.01e-0410752IPR001373
DomainCULLIN_1

CUL3 CUL7

7.01e-0410752PS01256
DomainSingle_hybrid_motif

ACACA PC

1.02e-0312752IPR011053
Domain-

ACACA PC

1.21e-03137523.40.50.20
DomainbZIP_Maf

NFE2L3 BACH2

1.21e-0313752IPR004826
DomainbZIP_Maf

NFE2L3 BACH2

1.21e-0313752PF03131
DomainATP-grasp

ACACA PC

1.40e-0314752IPR011761
DomainPreATP-grasp_dom

ACACA PC

1.40e-0314752IPR016185
DomainATP_GRASP

ACACA PC

1.40e-0314752PS50975
Domain-

ACACA PC

1.62e-03157523.30.1490.20
Domain-

NFE2L3 BACH2

1.84e-03167521.10.880.10
DomainATP_grasp_subdomain_1

ACACA PC

2.34e-0318752IPR013815
Domain-

ACACA PC

2.34e-03187523.30.470.20
DomainHATPase_c

TOP2A TOP2B

2.34e-0318752SM00387
DomainHATPase_c

TOP2A TOP2B

2.60e-0319752PF02518
Domain-

TOP2A TOP2B

2.88e-03207523.30.565.10
DomainTyr_Pase_AS

EPM2A PTPRZ1 DUSP16

3.16e-0373753IPR016130
Domain-

TOP2A TOP2B

3.18e-03217523.30.230.10
DomainHATPase_C

TOP2A TOP2B

3.18e-0321752IPR003594
DomainRibosomal_S5_D2-typ_fold_subgr

TOP2A TOP2B

3.49e-0322752IPR014721
DomainTYR_PHOSPHATASE_1

EPM2A PTPRZ1 DUSP16

5.01e-0386753PS00383
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

YTHDF1 CUL3 SHROOM4 ACACA CUL7 PC TOP2B

1.22e-0624477730349055
Pubmed

DNA topoisomerase II is dispensable for oocyte meiotic resumption but is essential for meiotic chromosome condensation and separation in mice.

TOP2A TOP2B

4.84e-06277224048577
Pubmed

ZEBs: Novel Players in Immune Cell Development and Function.

ZEB1 ZEB2

4.84e-06277230956067
Pubmed

Prognostic significance of ZEB1 and ZEB2 in digestive cancers: a cohort-based analysis and secondary analysis.

ZEB1 ZEB2

4.84e-06277228416756
Pubmed

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively.

TOP2A TOP2B

4.84e-0627721309226
Pubmed

Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases.

TOP2A TOP2B

4.84e-06277219222228
Pubmed

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

TOP2A TOP2B

4.84e-0627722555055
Pubmed

Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development.

ZEB1 ZEB2

4.84e-06277212609600
Pubmed

Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.

TOP2A TOP2B

4.84e-0627721331984
Pubmed

Expression of miRNAs and ZEB1 and ZEB2 correlates with histopathological grade in papillary urothelial tumors of the urinary bladder.

ZEB1 ZEB2

4.84e-06277224306957
Pubmed

Doxorubicin-induced cardiotoxicity is maturation dependent due to the shift from topoisomerase IIα to IIβ in human stem cell derived cardiomyocytes.

TOP2A TOP2B

4.84e-06277231106979
Pubmed

A biochemical analysis of topoisomerase II alpha and beta kinase activity found in HIV-1 infected cells and virus.

TOP2A TOP2B

4.84e-06277216091284
Pubmed

Either ZEB1 or ZEB2/SIP1 can play a central role in regulating the Epstein-Barr virus latent-lytic switch in a cell-type-specific manner.

ZEB1 ZEB2

4.84e-06277220375168
Pubmed

Prognostic Significance of Zinc Finger E-Box-Binding Homeobox Family in Glioblastoma.

ZEB1 ZEB2

4.84e-06277229476046
Pubmed

Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1 and ZEB-2 expression in pancreatic cancer.

ZEB1 ZEB2

4.84e-06277222213144
Pubmed

Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development.

ZEB1 ZEB2

4.84e-06277216957952
Pubmed

Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance.

TOP2A TOP2B

4.84e-06277214596941
Pubmed

Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.

TOP2A TOP2B

4.84e-06277217361331
Pubmed

Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.

TOP2A TOP2B

4.84e-06277210095062
Pubmed

The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.

ZEB1 ZEB2

4.84e-06277237819755
Pubmed

Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.

TOP2A TOP2B

4.84e-06277214996935
Pubmed

Structural organization of the human TOP2A and TOP2B genes.

TOP2A TOP2B

4.84e-0627729795238
Pubmed

The distribution of DNA topoisomerase II isoforms in differentiated adult mouse tissues.

TOP2A TOP2B

4.84e-0627728241259
Pubmed

Mining topoisomerase isoforms in gastric cancer.

TOP2A TOP2B

4.84e-06277232535049
Pubmed

Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development.

TOP2A TOP2B

4.84e-0627721380833
Pubmed

Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.

TOP2A TOP2B

4.84e-06277211927602
Pubmed

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.

TOP2A TOP2B

4.84e-06277217182034
Pubmed

Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.

TOP2A TOP2B

4.84e-06277228700616
Pubmed

Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.

TOP2A TOP2B

4.84e-06277228087392
Pubmed

Roles of the C-terminal domains of topoisomerase IIα and topoisomerase IIβ in regulation of the decatenation checkpoint.

TOP2A TOP2B

4.84e-06277228472494
Pubmed

Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer.

ZEB1 ZEB2

4.84e-06277222892238
Pubmed

Association of immunophenotype with expression of topoisomerase II α and β in adult acute myeloid leukemia.

TOP2A TOP2B

4.84e-06277232218491
Pubmed

The Zeb proteins δEF1 and Sip1 may have distinct functions in lens cells following cataract surgery.

ZEB1 ZEB2

4.84e-06277225082886
Pubmed

Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway.

ZEB1 ZEB2

4.84e-06277220025777
Pubmed

Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors.

ZEB1 ZEB2

4.84e-06277220424117
Pubmed

Involvement of human topoisomerase II isoforms in HIV-1 reverse transcription.

TOP2A TOP2B

4.84e-06277223399433
Pubmed

Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2.

TOP2A TOP2B

4.84e-06277230169847
Pubmed

Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.

TOP2A TOP2B

4.84e-06277215044480
Pubmed

C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.

TOP2A TOP2B

4.84e-06277217526531
Pubmed

The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.

TOP2A TOP2B

4.84e-0627729155056
Pubmed

Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.

TRAPPC2B TRAPPC2

4.84e-06277214597397
Pubmed

TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.

ZEB1 ZEB2

4.84e-06277221747944
Pubmed

Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.

TRAPPC2B TRAPPC2

4.84e-06277210431248
Pubmed

Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.

BACH2 IRF8

4.84e-06277229514092
Pubmed

DNA topoisomerase II distribution in mouse preimplantation embryos.

TOP2A TOP2B

4.84e-06277211835579
Pubmed

The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2.

ZEB1 ZEB2

4.84e-06277237948583
Pubmed

Characterization and immunological identification of cDNA clones encoding two human DNA topoisomerase II isozymes.

TOP2A TOP2B

4.84e-0627722556712
Pubmed

A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.

TOP2A TOP2B

4.84e-06277216712776
Pubmed

The role of epithelial-mesenchymal transition drivers ZEB1 and ZEB2 in mediating docetaxel-resistant prostate cancer.

ZEB1 ZEB2

4.84e-06277228133913
Pubmed

Active heterodimers are formed from human DNA topoisomerase II alpha and II beta isoforms.

TOP2A TOP2B

4.84e-0627728710863
Pubmed

Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).

TRAPPC2B TRAPPC2

4.84e-06277212939648
Pubmed

Distinct expression patterns for type II topoisomerases IIA and IIB in the early foetal human telencephalon.

TOP2A TOP2B

4.84e-06277226612825
Pubmed

Using a biochemical approach to identify the primary dimerization regions in human DNA topoisomerase IIalpha.

TOP2A TOP2B

4.84e-06277210473615
Pubmed

Cellular distribution of mammalian DNA topoisomerase II is determined by its catalytically dispensable C-terminal domain.

TOP2A TOP2B

4.84e-0627729224616
Pubmed

DNA damage response during chromatin remodeling in elongating spermatids of mice.

TOP2A TOP2B

4.84e-06277218032420
Pubmed

Discrete localization of different DNA topoisomerases in HeLa and K562 cell nuclei and subnuclear fractions.

TOP2A TOP2B

4.84e-0627728299728
Pubmed

Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a-/- mutants.

TOP2A TOP2B

4.84e-06277222111588
Pubmed

Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

TOP2A TOP2B

4.84e-06277217578914
Pubmed

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

ZEB1 ZEB2

4.84e-06277234550965
Pubmed

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.

ATXN2 BACH2 FANCA

9.86e-061977322561518
Pubmed

A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.

ZEB1 ZEB2

1.45e-05377221890822
Pubmed

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1.

TOP2A TOP2B

1.45e-05377217567603
Pubmed

TCF4 promotes colorectal cancer drug resistance and stemness via regulating ZEB1/ZEB2 expression.

ZEB1 ZEB2

1.45e-05377231933004
Pubmed

Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

1.45e-05377224968735
Pubmed

Deacetylase activity associates with topoisomerase II and is necessary for etoposide-induced apoptosis.

TOP2A TOP2B

1.45e-05377211136718
Pubmed

Expression of miR-9 and miR-200c, ZEB1, ZEB2 and E-cadherin in Non-Small Cell Lung Cancers in Iran.

ZEB1 ZEB2

1.45e-05377231244281
Pubmed

miR-144-3p inhibited the growth, metastasis and epithelial-mesenchymal transition of colorectal adenocarcinoma by targeting ZEB1/2.

ZEB1 ZEB2

1.45e-05377234226299
Pubmed

Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).

TOP2A TOP2B

1.45e-05377224808172
Pubmed

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.

TOP2A TOP2B

1.45e-05377212821127
Pubmed

The potential role of regulator of G-protein signaling 16 in cell motility mediated by δEF1 family proteins.

ZEB1 ZEB2

1.45e-05377226823172
Pubmed

A miRNA signature associated with human metastatic medullary thyroid carcinoma.

ZEB1 ZEB2

1.45e-05377224127332
Pubmed

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2.

ZEB1 ZEB2

1.45e-05377221518799
Pubmed

miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM.

ZEB1 ZEB2

1.45e-05377225833697
Pubmed

miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

1.45e-05377226022123
Pubmed

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.

ZEB1 ZEB2

1.45e-05377221411626
Pubmed

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.

ZEB1 ZEB2

1.45e-05377224165969
Pubmed

IL-6 selectively suppresses cDC1 specification via C/EBPβ.

IRF8 ZEB2

1.45e-05377237432392
Pubmed

Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype.

ZEB1 ZEB2

1.45e-05377223412770
Pubmed

DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-an LXR-dependent mechanism.

TOP2A TOP2B

1.45e-05377223466610
Pubmed

Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT.

ZEB1 ZEB2

1.45e-05377229052277
Pubmed

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53.

TOP2A TOP2B

1.45e-05377210666337
Pubmed

Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.

TOP2A TOP2B

1.45e-05377236633090
Pubmed

Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta.

ZEB1 ZEB2

1.45e-05377217615296
Pubmed

miR-590-3p suppresses cancer cell migration, invasion and epithelial-mesenchymal transition in glioblastoma multiforme by targeting ZEB1 and ZEB2.

ZEB1 ZEB2

1.45e-05377226556542
Pubmed

Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage.

TOP2A TOP2B

1.45e-05377216611985
Pubmed

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities.

TOP2A TOP2B

1.45e-0537729049244
Pubmed

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1.

ZEB1 ZEB2

1.45e-05377218376396
Pubmed

The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2.

ZEB1 ZEB2

1.45e-05377218411277
Pubmed

BMP4 signaling mediates Zeb family in developing mouse tooth.

ZEB1 ZEB2

1.45e-05377222350174
Pubmed

miR-200c inhibits TGF-β-induced-EMT to restore trastuzumab sensitivity by targeting ZEB1 and ZEB2 in gastric cancer.

ZEB1 ZEB2

1.45e-05377229302045
Pubmed

Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.

ACACA PC

2.89e-05477238447582
Pubmed

A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.

TRAPPC2B TRAPPC2

2.89e-05477211134351
Pubmed

SUMO-1 conjugation to human DNA topoisomerase II isozymes.

TOP2A TOP2B

2.89e-05477210862613
Pubmed

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression.

ZEB1 ZEB2

2.89e-05477225301070
Pubmed

miR-200b regulates cell migration via Zeb family during mouse palate development.

ZEB1 ZEB2

2.89e-05477222261924
Pubmed

MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors.

ZEB1 ZEB2

2.89e-05477217360662
Pubmed

Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma.

ZEB1 ZEB2

2.89e-05477223381389
Pubmed

Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells.

ZEB1 ZEB2

2.89e-05477228247944
Pubmed

Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants.

ZEB1 ZEB2

2.89e-05477216598713
Pubmed

MiR-525-5p Repressed Metastasis and Anoikis Resistance in Cervical Cancer via Blocking UBE2C/ZEB1/2 Signal Axis.

ZEB1 ZEB2

2.89e-05477231679088
CytobandYp11.3

ASMTL ASMT

3.28e-0416772Yp11.3
CytobandXp22.3

ASMTL ASMT

6.87e-0423772Xp22.3
Cytoband7q36

NUB1 EN2

9.48e-04277727q36
GeneFamilyTopoisomerases

TOP2A TOP2B

1.56e-0465921050
GeneFamilyCullins

CUL3 CUL7

2.89e-0485921032
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZEB1 ZEB2

1.07e-0315592529
GeneFamilyPseudoautosomal region 1|Solute carriers

ASMTL ASMT

2.99e-0325592715
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 ZEB1 BACH2 ROR2 NAV3 ZEB2 ADGRG4

5.71e-0820077774e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SHANK2 ACACA MSMO1 NKX2-1 ICA1 FAM149A

6.20e-071767763bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHROOM4 SHANK2 ACACA CSF3R MSMO1 NKX2-1

7.78e-071837766847c1252d6bb105524f812658112517fd351eab
ToppCellCOPD-Epithelial-Mesothelial|Epithelial / Disease state, Lineage and Cell class

BNC2 ZEB1 BACH2 ROR2 NAV3 ZEB2

9.11e-07188776159d63ecc3653a7449fc6acefd6ef0464845260e
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell|Adult / Lineage, Cell type, age group and donor

BNC2 ZEB1 ROR2 NAV3 GPSM2 ADGRG4

1.03e-06192776d21f0f577156f17c899b08871046a26b88aea011
ToppCelldroplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE TXNDC5 IRF8 ZEB2 FAM149A

1.15e-0517077529deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCelldroplet-Thymus-nan-21m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HFE TXNDC5 IRF8 ZEB2 FAM149A

1.15e-05170775dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCellAdult-Immune-dendritic_cell-D175|Adult / Lineage, Cell type, age group and donor

ZEB1 TXNDC5 SLC35F3 IRF8 NUB1

1.36e-051767751f0f1f953e6d61119f342de0d980aa1287511dba
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

CUL3 ZEB1 ICA1 DUSP16 PCNX1

1.52e-051807756bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SHROOM4 SHANK2 ACACA MSMO1 NKX2-1

1.56e-05181775576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

SHANK2 ACACA CSF3R MSMO1 NKX2-1

1.69e-05184775369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D122|Adult / Lineage, Cell type, age group and donor

BNC2 ZEB1 BACH2 NAV3 GPSM2

1.69e-051847752b7e6f91e11c228f0521e099886867d9e998e78d
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

SHANK2 SLC35F3 NKX2-1 PTPRZ1 ICA1

1.69e-05184775fa4915b0498f3069fd5ef497286445528f75187e
ToppCellAdult-Mesenchymal-matrix_fibroblast_2_cell-D231|Adult / Lineage, Cell type, age group and donor

BNC2 ZEB1 ROR2 NAV3 GPSM2

1.73e-05185775fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATRN FRMD4A BNC2 SIGLEC1 ZEB2

1.73e-051857758207f9eff113eed429e961748c6b17d672a13b33
ToppCellnormal_Lymph_Node-Myeloid_cells-mo-Mac|normal_Lymph_Node / Location, Cell class and cell subclass

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

1.87e-05188775e83de94a9b47a6a90e98face887eae031a322af6
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

SHANK2 ACACA CSF3R MSMO1 NKX2-1

2.02e-05191775a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SHANK2 NKX2-1 PTPRZ1 ICA1 TUFT1

2.07e-0519277539804d9ddc67c1b41887752df2503389eae44a1a
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

BNC2 ZEB1 BACH2 ROR2 NAV3

2.12e-05193775e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.17e-051947757c7091de47359760003e910cfbe63db5c99410d6
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SHANK2 NKX2-1 PTPRZ1 ICA1 TUFT1

2.17e-05194775c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCellILEUM-inflamed-(3)_moDC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.17e-05194775c9d2acab0bbcfa9a9113cf3b9f8147403f0beb43
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

FRMD4A ASMTL ROR2 NUB1 GRSF1

2.17e-0519477530f683725cb13ae32ef6846618801ec78e12397d
ToppCellRA-08._Macrophage|RA / Chamber and Cluster_Paper

FRMD4A PCNX1 SIGLEC1 ZEB2 SDS

2.17e-05194775ac26e5c71d5069622de72fa25a9c920887ac2c19
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.23e-05195775f289a44010788853d7726d4b5aa75f3c62186c08
ToppCellhuman_hepatoblastoma-Inflammatory_Monocytes|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

BNC2 IRF8 SIGLEC1 ZEB2 SDS

2.23e-05195775ba7f85e5307d96ac5ad7c952f8d094db9ca1790c
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SHANK2 NKX2-1 PTPRZ1 ICA1 TUFT1

2.28e-051967750a34a0009f479384f1994c6f977f942699a132c8
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

SHANK2 NKX2-1 PTPRZ1 ICA1 TUFT1

2.28e-051967757b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A CSF3R IRF8 SIGLEC1 ZEB2

2.28e-05196775cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SHANK2 NKX2-1 PTPRZ1 ICA1 TUFT1

2.34e-0519777522b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.34e-05197775e698a0bbb20bd4868ff4348f2ac9f609942b55fa
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRMD4A IRF8 SIGLEC1 ZEB2 SDS

2.40e-051987752b724d2a36843801984d46a969d33149b76c9771
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SHROOM4 SHANK2 ACACA CSF3R NKX2-1

2.46e-05199775725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellSigmoid-Macrophage-Macrophage|Sigmoid / Region, Cell class and subclass

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.52e-052007759ee3a799de7bade1bfe94b6827461633f02bc1dc
ToppCellMild-Myeloid-Macrophages-FCN1-SPP1+|Mild / Condition, Lineage, Cell class and cell subclass

CSF3R SIGLEC1 TNS1 ZEB2 SDS

2.52e-05200775e5afd8e2cb2c63899d49fe17011f474d20bb06ea
ToppCellSigmoid-Macrophage|Sigmoid / Region, Cell class and subclass

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.52e-05200775b07ac0ff3b8530e99094678fed80f35949cafac8
ToppCellSigmoid-(6)_Macrophage-(60)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.52e-05200775ad84a83a5a1893f7b053d39eddeca851463a8ff0
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FRMD4A IRF8 SIGLEC1 ZEB2 SDS

2.52e-0520077578d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCellParenchymal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 BACH2 ROR2 NAV3 ZEB2

2.52e-05200775cf433f9b43d7db07acaf70e060f8f77c974e72f3
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 ZEB1 NAV3 ZEB2 ADGRG4

2.52e-052007753dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 ZEB1 NAV3 TNS1 ZEB2

2.52e-05200775c318d14bd6fd6f42c597eb55ac9e2f48008aeb9b
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 BACH2 ROR2 NAV3 ZEB2

2.52e-05200775311fab076f2ceb258e3970eb21e39344b894042a
ToppCellSigmoid-(6)_Macrophage|Sigmoid / shred on region, Cell_type, and subtype

FRMD4A CSF3R SIGLEC1 ZEB2 SDS

2.52e-052007759e10cca4429de2c4c8c3c6cf2c9e28637a095be9
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

BNC2 BACH2 ROR2 NAV3 ZEB2

2.52e-0520077534f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCellCerebellum-Hematopoietic-MICROGLIA|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-0513977475cca1e6c1af289987d5d98455e9c6db81ecdd64
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-05139774a077ce50f6d6746d80de35abed5b6dc35b1145b9
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-05139774de34e2f51f6fda638357abb662c111a20b83e70b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ROR2 IRF8 TOP2A FANCA

9.91e-05139774c9bf98bed77415a1438f3f9e441a1346e75c26b0
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-051397740ae117308bd10d3a7d2688794c69dc5a31cfca5f
ToppCellCerebellum-Hematopoietic-MICROGLIA-MI1(C1qb)-MICROGLIA_Microglia.C1qb.Mrc1-Tmem119_(Resident_macrophage)--|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-05139774fac6a3100a277efa1db250e0c576be1a0c901e6d
ToppCellCerebellum-Hematopoietic|Cerebellum / BrainAtlas - Mouse McCarroll V32

CSF3R DPEP3 ASMT SIGLEC1

9.91e-051397743913c3828ad4cb5c71380519d0cf5f195e53c51d
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ACACA MSMO1 NKX2-1 SH3RF2

1.26e-041487749fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CSF3R EN2 ZEB2 SDS

1.51e-0415577477ae0b8d30bc3db4a73fd5340f99691a73d2684f
ToppCell5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BACH2 IRF8 TOP2A FANCA

1.55e-04156774203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NFE2L3 FRMD4A ASMT LMBRD2

1.55e-04156774c11ca6b1b5029c15aab91273cece70a487287839
ToppCellURO-Other-RBC|URO / Disease, Lineage and Cell Type

SNX4 TXNDC5 SLC35F3 IRF8

1.70e-04160774558f3b0719e2461a69e1b93b08e21675e8d07a5a
ToppCellURO-Other|URO / Disease, Lineage and Cell Type

SNX4 TXNDC5 SLC35F3 IRF8

1.70e-04160774b0923e6bacfaba8ca40aa5706bf270eea0938b0a
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SHANK2 NKX2-1 SH3RF2 FAM149A

1.79e-041627745c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Adult / Lineage, Cell type, age group and donor

SHANK2 CSF3R NKX2-1 FAM149A

1.83e-04163774e819a1d6d28290854aa0672b3a18fa9e293d8f23
ToppCell368C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

ZEB1 ROR2 NUB1 PC

1.92e-041657749d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Myeloid-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF3R DUSP16 SDS TUFT1

1.92e-041657747f293f64e7df7710b13016937cdd4f1af326f8c3
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 ZEB1 BACH2 ROR2

1.96e-0416677494636dbc039f794c735960c3425e00bdd5523602
ToppCellmild_COVID-19_(asymptomatic)-Plasmablast|World / disease group, cell group and cell class (v2)

EPM2A TXNDC5 QRICH2 TOP2A

2.01e-04167774f26ae4de4804a3486502e3df37eabf3dfca688f5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A SIGLEC1 ZEB2 SDS

2.05e-0416877461a5435b27b01ff1a509ea463a6af220c5d2c9b3
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FRMD4A SIGLEC1 ZEB2 SDS

2.05e-0416877426fce414439ccd204e3acb41f2b4f75072df5a26
ToppCell10x5'v1-week_17-19-Myeloid_DC-DC-DC1|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

SH3RF2 DPEP3 IRF8 FAM149A

2.10e-04169774488ba50631a64cb9e0d69219491c66ac824c9e7d
ToppCellCOVID-19_Convalescent-cDC|COVID-19_Convalescent / Disease condition and Cell class

BNC2 SH3RF2 PC SDS

2.20e-041717749ccaa9f1629818b0f63a5d930ee78c01e04cd98d
ToppCellCOVID-19_Convalescent-cDC-|COVID-19_Convalescent / Disease condition and Cell class

BNC2 SH3RF2 PC SDS

2.20e-04171774fb5fae8b3adafcbb7c5618d887966b418355ed4d
ToppCell10x3'2.3-week_17-19-Myeloid_DC-DC-tDC|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NBEAL1 IRF8 SIGLEC1 SDS

2.20e-04171774b327fb7813a3cdae06c8a4f8a0c256e9a20132f6
ToppCelldroplet-Lung-30m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l15|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ZNF512B IRF8 QRICH2 FAM149A

2.30e-04173774b6aed736d8480e3a6a5718aabd2fb79b1b75fa48
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX1 PC GPR151 FANCA

2.35e-04174774f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellPND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MICAL1 IRF8 TOP2A FANCA

2.35e-0417477409b091e24317c3f7bac043f04762a533e30793de
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FRMD4A MICAL1 SIGLEC1 ZEB2

2.35e-04174774d5c22b43531414951666ee7542a66ed9380e2d14
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACA PC RETSAT SDS

2.40e-041757745c38d4b6c03473d841e6203a7efaa6dcb2d59386
ToppCell390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FRMD4A ZEB1 SLC35F3 DUSP16

2.40e-041757746374ab186d7ccf7f6dfb858267edba8962789e15
ToppCellsevere_influenza-Plasmablast|World / disease group, cell group and cell class (v2)

TXNDC5 ESPNL TOP2A FAM149A

2.40e-04175774e6d6c44510d5dc4eb0bae820125e42366f7a4e74
ToppCellfacs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ATXN2 GPSM2 PC ZEB2

2.40e-04175774bb898796662b97f7459b7dda7cecf6a9bde8b055
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CSF3R DPEP3 SIGLEC1 ZEB2

2.45e-04176774926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

SHANK2 CSF3R NKX2-1 FAM149A

2.45e-041767743fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

DUSP16 TNS1 SDS TOP2A

2.50e-04177774470f54fe2b21c7350ea471e02039461a3808f700
ToppCell3'_v3-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

FRMD4A BNC2 TNS1 SDS

2.50e-0417777452c2ba74a8605260a2623e7d151286e504ac4d19
ToppCell10x5'v1-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DUSP16 SIGLEC1 EN2 SDS

2.50e-04177774945b2d0723a0a35c767604ae607d2c2d53bf0c82
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|390C / Donor, Lineage, Cell class and subclass (all cells)

PIK3R4 NFE2L3 ICA1 LMBRD2

2.56e-04178774829ea00c022a78d1861aa3ec53503272976775d9
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPM2A PCNX1 PC GPR151

2.56e-04178774fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

FRMD4A SIGLEC1 TNS1 SDS

2.67e-041807747be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellControl-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BNC2 ROR2 NAV3 GPSM2

2.67e-0418077408ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCellfacs-Marrow-B-cells-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L3 IRF8 TNS1 ZEB2

2.67e-04180774bf8d13d4db1af55b8c9fe16aaccf8743e000e005
ToppCellfacs-Marrow-B-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L3 IRF8 TNS1 ZEB2

2.67e-04180774839defb40f7cfb2711e9025194de636533f51bcd
ToppCellfacs-Marrow-B-cells-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NFE2L3 IRF8 TNS1 ZEB2

2.67e-0418077482965ed1b72a1873c24dd4553d39681596057316
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

BNC2 ZEB1 BACH2 ROR2

2.67e-0418077401f2e5d96016823482f89ba503d007d4bd88eeac
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FRMD4A DPEP3 ROR2 NAV3

2.67e-04180774810c7116007ee6668d3731e7ce1fcf697c7b24f6
ToppCellLPS_only-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NFE2L3 SHANK2 MSMO1 NKX2-1

2.73e-041817740513b9e6673ff7bf8e72ba123ca3794b65d10170
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PIK3R4 NFE2L3 ICA1 LMBRD2

2.73e-041817749275531e896e118cee043ed94fd31a0070d9581c
ToppCellCTRL-Myeloid-cDC|Myeloid / Disease state, Lineage and Cell class

ZEB1 BACH2 SDS FAM149A

2.78e-04182774ee137574b8f0e684a4a7cb26226877c471cae433
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BACH2 IRF8 ZEB2 TOP2B

2.78e-04182774f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell5'-Adult-Appendix-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FRMD4A CSF3R ZEB2 SDS

2.78e-04182774ea39b1b5db185b0cb11dfa2e01f3f972effbd770
ToppCelldroplet-Marrow-nan-3m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TXNDC5 IRF8 ZEB2 TOP2A

2.78e-04182774bc8d621be57f76d718d9b0f11e023b0f4dcb668d
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CUL3 BNC2 ICA1 DUSP16

2.84e-04183774807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

FRMD4A ACACA PC RETSAT

2.84e-04183774b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

FRMD4A ACACA PC RETSAT

2.84e-041837743f9011976782fa8aa95cdd6f00f07a91094d411b
DrugBerberine chloride [633-65-8]; Down 200; 10.8uM; HL60; HG-U133A

ZNF512B CDK17 SLC30A5 ACACA ATXN2 ZFR GRSF1 TOP2B FANCA

1.56e-081927691778_DN
DrugDexrazoxane

TOP2A TOP2B

1.10e-052762DB00380
DrugF14512

TOP2A TOP2B

1.10e-052762ctd:C534191
DrugDaunorubicin

TOP2A TOP2B

1.10e-052762DB00694
Drug1-nitro-9-aminoacridine

SIGLEC1 TOP2B

1.10e-052762CID000146709
DrugPapaverine hydrochloride [61-25-6]; Down 200; 10.6uM; HL60; HG-U133A

ACACA MSMO1 ATXN2 PCNX1 TNS1 GRSF1

3.20e-051817661755_DN
Drugacetyl-dephospho-CoA

ACACA PC

3.29e-053762CID000193680
DrugLY 294002; Down 200; 10uM; HL60; HT_HG-U133A

CUL3 NAV3 IRF8 TNS1 GRSF1 FANCA

3.96e-051887661177_DN
DrugLabetalol hydrochloride [32780-64-6]; Down 200; 11uM; MCF7; HT_HG-U133A

HFE FRMD4A EPM2A CARS1 PCNX1 CUL7

4.45e-051927666809_DN
DrugCalycanthine [595-05-1]; Up 200; 11.6uM; MCF7; HT_HG-U133A

HFE FRMD4A MICAL1 SLC9A8 EPM2A SLC30A5

4.58e-051937662764_UP
DrugGabazine [105538-73-6]; Up 200; 10.8uM; HL60; HT_HG-U133A

HFE EPM2A SLC30A5 NAV3 IRF8 PCNX1

4.72e-051947661316_UP
Drugrosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A

FRMD4A EPM2A PCNX1 CUL7 TNS1 FANCA

5.00e-051967665230_UP
DrugDiphemanil methylsulfate [62-97-5]; Down 200; 10.2uM; MCF7; HT_HG-U133A

HFE MICAL1 ICA1 PCNX1 CUL7 EN2

5.00e-051967664416_DN
DrugSulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A

HFE SHANK2 IRF8 PCNX1 EN2 SDS

5.00e-051967663847_UP
Drug0173570-0000 [211245-44-2]; Down 200; 1uM; PC3; HT_HG-U133A

SHANK2 NAV3 GPSM2 PCNX1 EN2 TRAPPC2

5.00e-051967667391_DN
DrugNifenazone [2139-47-1]; Down 200; 13uM; MCF7; HT_HG-U133A

HFE CDK17 FRMD4A EPM2A ICA1 PC

5.14e-051977662285_DN
DrugVitamin K2 [11032-49-8]; Down 200; 9uM; MCF7; HT_HG-U133A

HFE MICAL1 ICA1 PCNX1 CUL7 FANCA

5.29e-051987664356_DN
DrugAcemetacin [53164-05-9]; Down 200; 9.6uM; PC3; HT_HG-U133A

ZNF512B CUL3 SLC9A8 SLC30A5 SHANK2 TNS1

5.44e-051997666361_DN
DrugFuraltadone hydrochloride [3759-92-0]; Down 200; 11uM; PC3; HT_HG-U133A

CUL3 ZEB1 SLC30A5 NAV3 PCNX1 PC

5.44e-051997664313_DN
DiseaseX-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)

TRAPPC2B TRAPPC2

6.55e-062762DOID:0080362 (implicated_via_orthology)
DiseaseB cell deficiency (implicated_via_orthology)

TOP2A TOP2B

6.55e-062762DOID:2115 (implicated_via_orthology)
DiseaseFamilial Nonmedullary Thyroid Cancer

ZEB1 NKX2-1 WDR20 ZEB2

1.90e-0561764C3501844
DiseaseNonmedullary Thyroid Carcinoma

ZEB1 NKX2-1 WDR20 ZEB2

1.90e-0561764C3501843
DiseasePapillary thyroid carcinoma

ZEB1 NKX2-1 WDR20 ZEB2

7.35e-0586764C0238463
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

TRAPPC2B TRAPPC2

9.75e-056762DOID:14789 (implicated_via_orthology)
Diseaseinterleukin 17 measurement

EPM2A NAV3 FANCA

2.16e-0445763EFO_0008174
Diseaseleukemia

CSF3R TOP2A FANCA

3.91e-0455763C0023418
Diseaseacute myeloid leukemia (implicated_via_orthology)

TOP2A TOP2B

4.25e-0412762DOID:9119 (implicated_via_orthology)
Diseaserheumatic heart disease (biomarker_via_orthology)

ZEB1 ZEB2

4.25e-0412762DOID:0050827 (biomarker_via_orthology)
Diseaseinformation processing speed, response to cranial radiation therapy

FRMD4A ZFR SIGLEC1

4.58e-0458763EFO_0004363, EFO_0010950
Diseasefibroblast growth factor basic measurement

FRMD4A NAV3 GPSM2

4.81e-0459763EFO_0008130
DiseaseGenetic chronic primary adrenal insufficiency

ATXN2 BACH2

5.01e-0413762Orphanet_101960
Diseaselateral ventricle volume change measurement

NFE2L3 FAM149A

6.73e-0415762EFO_0021502
DiseaseMYELODYSPLASTIC SYNDROME

HFE CSF3R FANCA

6.99e-0467763C3463824
Diseaseskin neoplasm

BNC2 SHANK2 BACH2

9.33e-0474763EFO_0004198
DiseaseLeukemia, Myelocytic, Acute

CSF3R ASMTL BACH2 FANCA

1.05e-03173764C0023467
Diseaseunipolar depression, response to bupropion, mood disorder

CUL3 NAV3

1.09e-0319762EFO_0003761, EFO_0004247, EFO_0006326
Diseasefreckles

BNC2 FANCA

1.21e-0320762EFO_0003963
DiseaseHashimoto's thyroiditis

ATXN2 BACH2

2.04e-0326762EFO_0003779
DiseaseVitiligo

ATXN2 BACH2 FANCA

2.28e-03101763EFO_0004208

Protein segments in the cluster

PeptideGeneStartEntry
MSHSHPAGLLAAYNS

ERICH3

1

Q5RHP9
SSQAYSHGGLMADHL

BACH2

476

Q9BYV9
YHALSLAMHGFSVTL

ALG1

51

Q9BT22
GDHTFDGMAFSIHSY

ADGRG4

2571

Q8IZF6
MAALHESFTSSLNYG

BNC2

801

Q6ZN30
SFSSNLNHYGMTHVA

ACACA

1201

Q13085
HYHMLLSSAGFRDFQ

ASMT

316

P46597
HGAVTAAYHMTAAGV

NKX2-1

61

P43699
GTHYSNSAGVMHYLI

NBEAL1

2096

Q6ZS30
GHAFSLFDSHDSMYP

QRICH2

931

Q9H0J4
AADFGTTSSLHFVHM

GRSF1

391

Q12849
GMGYSTHAAQQVLHA

NUB1

441

Q9Y5A7
DFHHMNFIGNYASTF

MSMO1

251

Q15800
MSALHAAAARGHYSL

ESPNL

206

Q6ZVH7
HTTDFYFNIAGHQAM

EPM2A

141

O95278
AYTALGNHDQAMHFA

GPSM2

331

P81274
HHFSSSFYSDMNGVM

FAM149A

536

A5PLN7
ASDGEYSLHGFIMHN

ASMTL

366

O95671
GHSAVLHNSTMYVFG

ATRN

616

O75882
SATQYGAHEQTHAMY

ATXN2

1091

Q99700
YHSSAQFSTHGAHTM

C9orf131

246

Q5VYM1
TASHHMSSNLESFLY

PCNX1

1806

Q96RV3
DAHHSAFSQMVISFY

IRF8

196

Q02556
HYAHGSVAHSLMASA

OR51J1

156

Q9H342
AMSSSAAGKYHFSNL

NAV3

1466

Q8IVL0
ESNGSAGSHYITLHM

CUL7

866

Q14999
ISDGMNSSAHYHVNF

NFE2L3

291

Q9Y4A8
IAYLSHFHSAFKSMA

MICAL1

601

Q8TDZ2
SHSMHSFLHQYTGSF

CDK17

51

Q00537
RSHSLHYLFMGASEQ

HFE

26

Q30201
HMHSASLQGLTISYA

PTPRZ1

1251

P23471
SSSMNVSFAHLHFAG

GPR151

11

Q8TDV0
MGAHLNAYSTREHTA

UQCRC1

116

P31930
YRAGEHFAMFAHNTL

GAL3ST3

191

Q96A11
HFAMFAHNTLAYDLG

GAL3ST3

196

Q96A11
TSHSSSEHYYPAQMN

FRMD4A

751

Q9P2Q2
NALMDFHQSSRSYDH

FANCA

986

O15360
QHHMGSADLNATFYG

CUL3

551

Q13618
SVSYSASMAASLHGF

DUSP16

406

Q9BY84
QHEHGYTALMFAALS

ANKMY2

76

Q8IV38
YHIHLMAASQAGATN

CSF3R

596

Q99062
VHLMAQGLYNHSTTA

EN2

311

P19622
FRHHMYTNVSGLTSF

DPEP3

236

Q9H4B8
IAMETFGAHSFHAAT

SDS

191

P20132
SHTMAAIHESFKGYQ

ICA1

246

Q05084
FSYAAVHTGNMFREH

OR14I1

151

A6ND48
LSTFSHFSLFHMAAN

PARL

211

Q9H300
YGVTPNHSAFSMHAL

RETSAT

266

Q6NUM9
LQSAGHHMDVYASSI

SNX4

276

O95219
DASHMGHARSYISFD

CARS1

61

P49589
AQLAGSVAEMSAYHH

TOP2B

766

Q02880
HHQTDAYSLLFSGML

LMBRD2

466

Q68DH5
HNSHTGAAASVMYTV

OR7A10

266

O76100
MDQSYHSADQPYHAT

SHROOM4

826

Q9ULL8
FSGIVMSHYTHHNLS

SLC9A8

326

Q9Y2E8
SESLFLVAHSSGNMY

WDR20

161

Q8TBZ3
VAQIAAGMEYLSSHH

ROR2

596

Q01974
MTYADGFHSHSVIGI

SLC35F3

221

Q8IY50
HLLFYGADMSAQNAS

SHANK2

316

Q9UPX8
ATLNAFLYHMGQHSN

ATAD3B

431

Q5T9A4
MHHFNSGAQSVLAYA

PIK3R4

1101

Q99570
YAMVSSHSAGHSLAS

TUFT1

51

Q9NNX1
TAAGLMHTFNAHAAT

SEPHS2

301

Q99611
MHTFNAHAATDITGF

SEPHS2

306

Q99611
SFYMSHLTQHTGIHA

ZNF595

181

Q8IYB9
MSVLGHYNNFFFAAH

RYR3

4631

Q15413
TSHYAHDPSGMFRSQ

TNS1

606

Q9HBL0
LAFTHVARAQAGMYH

SIGLEC1

1496

Q9BZZ2
MSGSFYFVIVGHHDN

TRAPPC2

1

P0DI81
GKRFSHSGSYSQHMN

ZEB1

966

P37275
QLAGSVAEMSSYHHG

TOP2A

746

P11388
SKAGLNYHTMAEHSA

ZNF512B

551

Q96KM6
FTHSGAAAAAAAAQY

ZFR

31

Q96KR1
YFQHMSGLSTGFHDV

SLC30A5

731

Q8TAD4
YTADMFTHGIQSAAH

TXNDC5

66

Q8NBS9
SANMFVALHSYSAHG

SH3RF2

381

Q8TEC5
GKRFSHSGSYSQHMN

ZEB2

1061

O60315
MSGSFYFVIVGHHDN

TRAPPC2B

1

P0DI82
YTNLHFQAHSMGLGS

PC

871

P11498
LTTYGQLSNGDHHFM

YTHDF1

86

Q9BYJ9