Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransforming growth factor beta receptor binding

LEFTY2 LEFTY1 SNX25

1.96e-0531343GO:0005160
GeneOntologyMolecularFunctionnodal binding

LEFTY2 LEFTY1

7.83e-058342GO:0038100
GeneOntologyMolecularFunctionhistone kinase activity

MST1 MST1L

1.03e-0328342GO:0035173
GeneOntologyBiologicalProcessnegative regulation of nodal receptor complex assembly

LEFTY2 LEFTY1

2.80e-062352GO:1900124
GeneOntologyBiologicalProcessregulation of nodal receptor complex assembly

LEFTY2 LEFTY1

2.80e-062352GO:1900123
GeneOntologyBiologicalProcessnodal receptor complex assembly

LEFTY2 LEFTY1

2.80e-062352GO:0038099
GeneOntologyBiologicalProcessnegative regulation of nodal signaling pathway

LEFTY2 LEFTY1

5.84e-057352GO:1900108
GeneOntologyBiologicalProcessregulation of nodal signaling pathway

LEFTY2 LEFTY1

1.00e-049352GO:1900107
GeneOntologyBiologicalProcesspositive regulation of mammary gland epithelial cell proliferation

MST1 MST1L

1.00e-049352GO:0033601
GeneOntologyBiologicalProcessmammary duct terminal end bud growth

MST1 MST1L

1.00e-049352GO:0060763
GeneOntologyCellularComponentCul2-RING ubiquitin ligase complex

VHLL ZER1 KLHDC10

6.07e-0547343GO:0031462
MousePhenoabnormal left renal vein morphology

LEFTY2 LEFTY1

4.76e-062312MP:0011327
MousePhenoabnormal renal vein morphology

LEFTY2 LEFTY1

4.76e-062312MP:0011323
MousePhenoabnormal kidney venous blood vessel morphology

LEFTY2 LEFTY1

1.43e-053312MP:0011311
MousePhenocomplete atrioventricular septal defect

LEFTY2 PCSK5 LEFTY1

2.48e-0526313MP:0010413
MousePhenoabnormal large intestine placement

LEFTY2 LEFTY1

2.85e-054312MP:0003284
MousePhenoatrioventricular septal defect

LRP1 LEFTY2 PCSK5 LEFTY1

3.37e-0584314MP:0010412
MousePhenoabnormal atrioventricular septum morphology

LRP1 LEFTY2 PCSK5 LEFTY1

3.87e-0587314MP:0010592
MousePhenoabsent heart right ventricle

LEFTY2 LEFTY1

7.10e-056312MP:0003872
MousePhenoleft atrial isomerism

LEFTY2 LEFTY1

1.32e-048312MP:0008461
MousePhenotransposition of great arteries

LEFTY2 PCSK5 LEFTY1

1.50e-0447313MP:0004110
MousePhenoaccessory spleen

LEFTY2 LEFTY1

1.70e-049312MP:0003342
MousePhenotricuspid valve atresia

LEFTY2 LEFTY1

1.70e-049312MP:0006123
MousePhenodextrocardia

LEFTY2 PCSK5 LEFTY1

1.91e-0451313MP:0000644
MousePhenoabnormal cardiac outflow tract development

LEFTY2 PCSK5 LEFTY1 VCAN

2.08e-04134314MP:0006126
MousePhenoincreased heart weight

LRP1 PCSK5 ZER1 RIC1 NOTCH3 C16orf89

2.21e-04403316MP:0002833
MousePhenoright aortic arch

LEFTY2 PCSK5 LEFTY1

3.10e-0460313MP:0004158
MousePhenoabsent heart

LEFTY2 LEFTY1

4.26e-0414312MP:0011388
MousePhenoabnormal hepatic portal vein morphology

LEFTY2 LEFTY1

5.60e-0416312MP:0010668
MousePhenoabnormal heart position or orientation

LEFTY2 PCSK5 LEFTY1

5.75e-0474313MP:0006065
MousePhenoabnormal heart atrium arrangement

LEFTY2 LEFTY1

6.34e-0417312MP:0014319
MousePhenoembryonic lethality during organogenesis, complete penetrance

LRP1 LEFTY2 VHLL COL5A2 LEFTY1 EPCAM VCAN

7.02e-04700317MP:0011098
MousePhenoabnormal intestine placement

LEFTY2 LEFTY1

7.12e-0418312MP:0014023
MousePhenoabsent notochord

LEFTY2 LEFTY1

7.95e-0419312MP:0000932
MousePhenoabnormal heart weight

LRP1 PCSK5 ZER1 RIC1 NOTCH3 C16orf89

8.40e-04518316MP:0004857
MousePhenoabnormal azygos vein morphology

LEFTY2 LEFTY1

8.82e-0420312MP:0011569
MousePhenoatrial septal defect

LEFTY2 PCSK5 LEFTY1

9.54e-0488313MP:0010403
MousePhenoheterotaxia

LEFTY2 PCSK5 LEFTY1

1.02e-0390313MP:0004133
MousePhenoabnormal limb bud morphology

LRP1 PCSK5 VHLL

1.05e-0391313MP:0005650
MousePhenoabnormal vascular development

LEFTY2 PCSK5 VHLL LEFTY1 VCAN NOTCH3

1.06e-03542316MP:0000259
MousePhenoabnormal tricuspid valve morphology

LEFTY2 LEFTY1

1.50e-0326312MP:0002624
MousePhenoabnormal heart septum morphology

LRP1 LEFTY2 PCSK5 LEFTY1 VCAN

1.50e-03388315MP:0006113
MousePhenoabnormal thrombosis

LAT EPCAM NOTCH3

1.63e-03106313MP:0005048
MousePhenoabnormal heart atrium morphology

LEFTY2 PCSK5 LEFTY1 VCAN

1.64e-03232314MP:0003105
MousePhenoabnormal interatrial septum morphology

LEFTY2 PCSK5 LEFTY1

1.68e-03107313MP:0000282
DomainLRDF

LEFTY2 LEFTY1

3.41e-062352IPR003942
DomainPAN_AP

MST1 MST1L

3.40e-055352SM00473
DomainPAN

MST1 MST1L

7.12e-057352PS50948
DomainPan_app

MST1 MST1L

7.12e-057352IPR003609
DomainPAN_1

MST1 MST1L

7.12e-057352PF00024
DomainEGF

LRP1 PCSK5 ADAM23 VCAN NOTCH3

7.21e-05235355SM00181
DomainEGF-like_dom

LRP1 PCSK5 ADAM23 VCAN NOTCH3

9.47e-05249355IPR000742
DomainKringle

MST1 MST1L

4.56e-0417352IPR000001
DomainKringle

MST1 MST1L

4.56e-0417352PF00051
DomainKRINGLE_1

MST1 MST1L

4.56e-0417352PS00021
DomainKringle_CS

MST1 MST1L

4.56e-0417352IPR018056
DomainKR

MST1 MST1L

4.56e-0417352SM00130
DomainKRINGLE_2

MST1 MST1L

4.56e-0417352PS50070
DomainEGF_Ca-bd_CS

LRP1 VCAN NOTCH3

7.88e-0497353IPR018097
DomainEGF_CA

LRP1 VCAN NOTCH3

8.36e-0499353PS01187
DomainASX_HYDROXYL

LRP1 VCAN NOTCH3

8.61e-04100353PS00010
DomainEGF_3

LRP1 ADAM23 VCAN NOTCH3

9.42e-04235354PS50026
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1 VCAN NOTCH3

1.02e-03106353IPR000152
DomainTGFb_propeptide

LEFTY2 LEFTY1

1.25e-0328352PF00688
DomainTGF-b_N

LEFTY2 LEFTY1

1.25e-0328352IPR001111
DomainEGF_1

LRP1 ADAM23 VCAN NOTCH3

1.27e-03255354PS00022
DomainEGF-like_CS

LRP1 ADAM23 VCAN NOTCH3

1.39e-03261354IPR013032
DomainEGF_2

LRP1 ADAM23 VCAN NOTCH3

1.47e-03265354PS01186
DomainEGF_CA

LRP1 VCAN NOTCH3

1.53e-03122353SM00179
DomainEGF-like_Ca-bd_dom

LRP1 VCAN NOTCH3

1.60e-03124353IPR001881
DomainTGF-beta-rel

LEFTY2 LEFTY1

1.63e-0332352IPR015615
DomainSpectrin/alpha-actinin

AKAP6 MACF1

1.63e-0332352IPR018159
DomainSPEC

AKAP6 MACF1

1.63e-0332352SM00150
DomainKringle-like

MST1 MST1L

1.63e-0332352IPR013806
DomainTGFb_CS

LEFTY2 LEFTY1

1.63e-0332352IPR017948
DomainEGF

LRP1 VCAN NOTCH3

1.68e-03126353PF00008
DomainTGFB

LEFTY2 LEFTY1

2.18e-0337352SM00204
DomainTGF_BETA_2

LEFTY2 LEFTY1

2.18e-0337352PS51362
DomainTGF_beta

LEFTY2 LEFTY1

2.18e-0337352PF00019
DomainTGF-b_C

LEFTY2 LEFTY1

2.18e-0337352IPR001839
DomainTGF_BETA_1

LEFTY2 LEFTY1

2.18e-0337352PS00250
DomainLDLR_class-A_CS

LRP1 LDLRAD3

2.54e-0340352IPR023415
DomainGrowth_fac_rcpt_

LRP1 PCSK5 NOTCH3

3.08e-03156353IPR009030
DomainLdl_recept_a

LRP1 LDLRAD3

3.21e-0345352PF00057
Domain-

LRP1 LDLRAD3

3.35e-03463524.10.400.10
DomainLDLRA_1

LRP1 LDLRAD3

3.65e-0348352PS01209
DomainLDrepeatLR_classA_rpt

LRP1 LDLRAD3

3.80e-0349352IPR002172
DomainLDLa

LRP1 LDLRAD3

3.80e-0349352SM00192
DomainLDLRA_2

LRP1 LDLRAD3

3.80e-0349352PS50068
DomainEGF_extracell

ADAM23 NOTCH3

5.64e-0360352IPR013111
DomainEGF_2

ADAM23 NOTCH3

5.64e-0360352PF07974
Domain-

LEFTY2 LEFTY1

6.99e-03673522.10.90.10
DomainCystine-knot_cytokine

LEFTY2 LEFTY1

6.99e-0367352IPR029034
PathwayREACTOME_SIGNALING_BY_MST1

MST1 MST1L

4.15e-056242MM15492
PathwayBIOCARTA_MSP_PATHWAY

MST1 MST1L

5.80e-057242MM1580
PathwayWP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION

MST1 MST1L

7.73e-058242MM15986
PathwayWP_MIR127_IN_MESENDODERM_DIFFERENTIATION

LEFTY2 LEFTY1

1.81e-0412242MM15910
PathwayREACTOME_REGULATION_OF_SIGNALING_BY_NODAL

LEFTY2 LEFTY1

1.81e-0412242M26952
PathwayREACTOME_SIGNALING_BY_NODAL

LEFTY2 LEFTY1

6.88e-0423242M511
Pubmed

Decidual differentiation of stromal cells promotes Proprotein Convertase 5/6 expression and lefty processing.

LEFTY2 PCSK5 LEFTY1

9.34e-10335316141390
Pubmed

The regulated cell surface zymogen activation of the proprotein convertase PC5A directs the processing of its secretory substrates.

LEFTY2 PCSK5 LEFTY1

1.86e-08635318039650
Pubmed

Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.

LEFTY2 PCSK5 LEFTY1

5.18e-071635320876279
Pubmed

Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.

MST1 MST1L

9.84e-07235210728827
Pubmed

Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.

MST1 MST1L

9.84e-07235216961763
Pubmed

Lefty antagonises TGF-beta1 induced epithelial-mesenchymal transition in tubular epithelial cells.

LEFTY2 LEFTY1

9.84e-07235220171171
Pubmed

Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.

LEFTY2 LEFTY1

9.84e-0723529496783
Pubmed

A functional role of LEFTY during progesterone therapy for endometrial carcinoma.

LEFTY2 LEFTY1

9.84e-07235229268772
Pubmed

Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.

MST1 MST1L

9.84e-07235239253972
Pubmed

Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.

MST1 MST1L

9.84e-07235229760744
Pubmed

Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.

LEFTY2 LEFTY1

9.84e-07235229286065
Pubmed

Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.

MST1 MST1L

9.84e-07235232017081
Pubmed

LEFTY2 alleviates hepatic stellate cell activation and liver fibrosis by regulating the TGF-β1/Smad3 pathway.

LEFTY2 LEFTY1

9.84e-07235232745796
Pubmed

Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.

MST1 MST1L

9.84e-07235230708325
Pubmed

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

MST1 MST1L

9.84e-07235224409221
Pubmed

Lefty1 and lefty2 control the balance between self-renewal and pluripotent differentiation of mouse embryonic stem cells.

LEFTY2 LEFTY1

9.84e-07235224147624
Pubmed

Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.

MST1 MST1L

9.84e-07235227696525
Pubmed

Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.

MST1 MST1L

9.84e-0723528393443
Pubmed

Isolation, characterization, and function of EBAF/LEFTY B: role in infertility.

LEFTY2 LEFTY1

9.84e-07235221401636
Pubmed

Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.

MST1 MST1L

9.84e-0723528340069
Pubmed

Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.

MST1 MST1L

9.84e-0723529486989
Pubmed

MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.

MST1 MST1L

9.84e-07235227609031
Pubmed

Lefty1 Ameliorates Post-infarction Fibrosis by Suppressing p-Smad2 and p-ERK1/2 Signaling Pathways.

LEFTY2 LEFTY1

9.84e-07235233409963
Pubmed

Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.

MST1 MST1L

9.84e-07235224980820
Pubmed

LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry.

LEFTY2 LEFTY1

9.84e-07235229230527
Pubmed

Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.

MST1 MST1L

9.84e-07235233887258
Pubmed

LEFTY, a member of the transforming growth factor-beta superfamily, inhibits uterine stromal cell differentiation: a novel autocrine role.

LEFTY2 LEFTY1

9.84e-07235220056823
Pubmed

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.

LEFTY2 LEFTY1

9.84e-07235210053005
Pubmed

HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.

MST1 MST1L

9.84e-07235225938541
Pubmed

Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.

MST1 MST1L

9.84e-07235231206688
Pubmed

Lefty is expressed in mouse endometrium in estrous cycle and peri-implantation period.

LEFTY2 LEFTY1

9.84e-07235215640253
Pubmed

Mutation analysis of human LEFTY A and LEFTY B genes in children with Ivemark syndrome.

LEFTY2 LEFTY1

9.84e-07235211100524
Pubmed

Molecular analysis of LEFTY-expressing cells in early human embryoid bodies.

LEFTY2 LEFTY1

9.84e-07235217038673
Pubmed

LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.

LRP1 LDLRAD3

2.95e-06335221795536
Pubmed

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.

MST1 MST1L

2.95e-06335227496379
Pubmed

Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.

MST1 MST1L

2.95e-06335212804176
Pubmed

Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.

MST1 MST1L

2.95e-06335212606483
Pubmed

Two modes by which Lefty proteins inhibit nodal signaling.

LEFTY2 LEFTY1

2.95e-06335215062104
Pubmed

Nodal and lefty signaling regulates the growth of pancreatic cells.

LEFTY2 LEFTY1

2.95e-06335218393305
Pubmed

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

LEFTY2 LEFTY1

2.95e-06335217011489
Pubmed

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

MST1 MST1L

2.95e-06335210225971
Pubmed

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.

MST1 MST1L

2.95e-06335236623453
Pubmed

Lefty-1 inhibits renal epithelial-mesenchymal transition by antagonizing the TGF-β/Smad signaling pathway.

LEFTY2 LEFTY1

2.95e-06335232065356
Pubmed

Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.

MST1 MST1L

2.95e-06335237184367
Pubmed

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.

MST1 MST1L

2.95e-06335238430683
Pubmed

Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.

MST1 MST1L

2.95e-06335212538524
Pubmed

Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.

MST1 MST1L

2.95e-06335219339990
Pubmed

Lefty-1 alleviates TGF-β1-induced fibroblast-myofibroblast transdifferentiation in NRK-49F cells.

LEFTY2 LEFTY1

2.95e-06335226316705
Pubmed

TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.

MST1 MST1L

2.95e-06335226698664
Pubmed

CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.

MST1 MST1L

2.95e-06335238288506
Pubmed

The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.

MST1 MST1L

2.95e-0633528545120
Pubmed

Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.

MST1 MST1L

2.95e-06335225049204
Pubmed

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.

LRP1 NOTCH3

2.95e-06335220472562
Pubmed

Requirements of LEFTY and Nodal overexpression for tumor cell survival under hypoxia in glioblastoma.

LEFTY2 LEFTY1

2.95e-06335233111989
Pubmed

Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.

MST1 MST1L

2.95e-0633521832957
Pubmed

Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.

MST1 MST1L

2.95e-06335225183307
Pubmed

MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.

MST1 MST1L

2.95e-06335235525373
Pubmed

Role of asymmetric signals in left-right patterning in the mouse.

LEFTY2 LEFTY1

2.95e-06335211471154
Pubmed

MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.

MST1 MST1L

2.95e-06335227510910
Pubmed

Lefty1 alleviates renal tubulointerstitial injury in mice with unilateral ureteral obstruction.

LEFTY2 LEFTY1

2.95e-06335226647776
Pubmed

TGFβ signaling in establishing left-right asymmetry.

LEFTY2 LEFTY1

2.95e-06335224704359
Pubmed

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.

MST1 MST1L

2.95e-06335230063115
Pubmed

Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.

MST1 MST1L

2.95e-06335231976559
Pubmed

Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.

MST1 MST1L

2.95e-06335227218122
Pubmed

IFT46 plays an essential role in cilia development.

LEFTY2 LEFTY1

2.95e-06335225722189
Pubmed

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.

LEFTY2 LEFTY1

2.95e-0633529865700
Pubmed

Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.

MST1 MST1L

2.95e-06335232468668
Pubmed

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.

MST1 MST1L

2.95e-06335217395874
Pubmed

Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes.

LEFTY2 LEFTY1

2.95e-06335210886363
Pubmed

Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.

MST1 MST1L

2.95e-06335229127009
Pubmed

Nodal activates smad and extracellular signal-regulated kinases 1/2 pathways promoting renal cell carcinoma proliferation.

LEFTY2 LEFTY1

2.95e-06335225672326
Pubmed

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.

MST1 MST1L

2.95e-06335227465533
Pubmed

Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.

MST1 MST1L

2.95e-06335224852423
Pubmed

Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.

LEFTY2 LEFTY1

2.95e-06335227655833
Pubmed

Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.

MST1 MST1L

2.95e-06335230771091
Pubmed

Association of maternal hypertension and diabetes with variants of the NKX2-5, LEFTY1 and LEFTY2 genes in children with congenital heart defects: a case-control study from Pakistani Population.

LEFTY2 LEFTY1

2.95e-06335237097539
Pubmed

Embryonic asymmetry: the left side gets all the best genes.

LEFTY2 LEFTY1

2.95e-0633529889116
Pubmed

MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.

MST1 MST1L

2.95e-06335234967918
Pubmed

Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.

MST1 MST1L

2.95e-06335238898027
Pubmed

WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.

MST1 MST1L

2.95e-06335232045478
Pubmed

Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.

MST1 MST1L

2.95e-06335227940445
Pubmed

Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.

MST1 MST1L

5.90e-06435226903296
Pubmed

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

LEFTY2 LEFTY1

5.90e-0643529348041
Pubmed

Asymmetric Nodal expression in the mouse is governed by the combinatorial activities of two distinct regulatory elements.

LEFTY2 LEFTY1

5.90e-06435215454269
Pubmed

Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

MST1 MST1L

5.90e-06435223527007
Pubmed

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.

LEFTY2 LEFTY1

5.90e-0643529708732
Pubmed

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.

LEFTY2 LEFTY1

5.90e-0643529708731
Pubmed

A cell-intrinsic role for Mst1 in regulating thymocyte egress.

MST1 MST1L

5.90e-06435219692642
Pubmed

Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.

MST1 MST1L

5.90e-06435221078906
Pubmed

MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.

MST1 MST1L

5.90e-06435236618429
Pubmed

Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.

MST1 MST1L

5.90e-06435228480597
Pubmed

Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.

MST1 MST1L

5.90e-06435216892067
Pubmed

Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.

MST1 MST1L

5.90e-06435225659841
Pubmed

Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.

MST1 MST1L

5.90e-06435235715527
Pubmed

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

LEFTY2 LEFTY1

5.90e-0643528610011
Pubmed

Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.

MST1 MST1L

5.90e-06435226538561
Pubmed

The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.

LEFTY2 LEFTY1

5.90e-06435223544137
Pubmed

MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.

MST1 MST1L

5.90e-06435223818595
Pubmed

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.

MST1 MST1L

5.90e-06435225074980
Pubmed

RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.

MST1 MST1L

5.90e-06435235626096
InteractionLEFTY1 interactions

LEFTY2 LEFTY1

1.75e-054352int:LEFTY1
InteractionLEFTY2 interactions

LEFTY2 LEFTY1

1.75e-054352int:LEFTY2
Cytoband1q42.1

LEFTY2 LEFTY1

3.71e-05123521q42.1
CytobandEnsembl 112 genes in cytogenetic band chr7q32

COPG2 KLHDC10

2.51e-0397352chr7q32
CoexpressionNABA_MATRISOME

LEFTY2 PCSK5 MST1 COL5A2 LEFTY1 FNDC1 MST1L ADAM23 VCAN

5.08e-061008359MM17056
CoexpressionNABA_MATRISOME

LEFTY2 PCSK5 MST1 COL5A2 LEFTY1 FNDC1 MST1L ADAM23 VCAN

5.87e-061026359M5889
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_LATE_AIRWAY_SMC_CELL

LEFTY2 FNDC1 EPCAM C16orf89

1.66e-05115354M45671
CoexpressionTESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN

LEFTY2 LEFTY1

2.59e-056352M1764
CoexpressionTESAR_ALK_TARGETS_HUMAN_ES_4D_DN

LEFTY2 LEFTY1

2.59e-056352M16516
CoexpressionDESCARTES_FETAL_THYMUS_STROMAL_CELLS

LRP1 COL5A2 FNDC1 VCAN

3.30e-05137354M40313
CoexpressionTESAR_ALK_TARGETS_HUMAN_ES_5D_DN

LEFTY2 LEFTY1

3.62e-057352M2811
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

LEFTY2 COL5A2 LEFTY1 COPG2 ADAM23 VCAN

6.28e-05526356M2520
CoexpressionKOHOUTEK_CCNT2_TARGETS

LEFTY2 LEFTY1 CEP295

6.40e-0558353M2402
CoexpressionTESAR_ALK_AND_JAK_TARGETS_MOUSE_ES_D4_DN

LEFTY2 LEFTY1

7.74e-0510352MM741
CoexpressionTURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_DUCTAL_NORMAL_UP

COL5A2 FNDC1 VCAN

1.08e-0469353M10165
CoexpressionRAO_BOUND_BY_SALL4_ISOFORM_B

LEFTY2 COL5A2 LEFTY1 COPG2 ADAM23 VCAN

1.12e-04584356MM1080
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_AIRWAY_SMC_2_CELL

LEFTY2 FNDC1 EPCAM C16orf89

1.15e-04189354M45678
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MID_AIRWAY_SMC_1_CELL

PCSK5 EPCAM C16orf89

1.17e-0471353M45677
CoexpressionTURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_UP

COL5A2 NAA25 VCAN

1.32e-0474353M4479
CoexpressionTURASHVILI_BREAST_LOBULAR_CARCINOMA_VS_LOBULAR_NORMAL_DN

COL5A2 FNDC1 VCAN

1.32e-0474353M13547
CoexpressionGSE28449_WT_VS_LRF_KO_GERMINAL_CENTER_BCELL_UP

AKAP6 PCSK5 KLHDC10 VCAN

1.40e-04199354M8347
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN

AKAP6 LRP1 MST1 LEFTY1 KLHDC10 LAT NOTCH3

1.69e-04909357M41018
CoexpressionMENON_FETAL_KIDNEY_3_STROMAL_CELLS

COL5A2 MACF1 VCAN

1.73e-0481353M39253
CoexpressionKOHOUTEK_CCNT2_TARGETS

LEFTY2 LEFTY1 CEP295

1.73e-0481353MM938
CoexpressionSILIGAN_TARGETS_OF_EWS_FLI1_FUSION_UP

KAZN RIC1

1.80e-0415352M9251
CoexpressionMIKKELSEN_MEF_ICP_WITH_H3K27ME3

LEFTY2 MST1 LEFTY1 MST1L

2.17e-04223354MM838
CoexpressionHERNANDEZ_MITOTIC_ARREST_BY_DOCETAXEL_2_DN

MST1L VCAN

2.61e-0418352M1193
CoexpressionJAATINEN_HEMATOPOIETIC_STEM_CELL_DN

PCSK5 ZER1 LAT VCAN

2.65e-04235354M6905
CoexpressionGAO_LARGE_INTESTINE_24W_C1_DCLK1POS_PROGENITOR

COL5A2 FNDC1 VCAN

3.13e-0499353M39152
CoexpressionNABA_MATRISOME_ASSOCIATED

LEFTY2 PCSK5 MST1 LEFTY1 MST1L ADAM23

3.95e-04738356MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

LEFTY2 PCSK5 MST1 LEFTY1 MST1L ADAM23

4.33e-04751356M5885
CoexpressionCUI_DEVELOPING_HEART_C3_FIBROBLAST_LIKE_CELL

LRP1 COL5A2 FNDC1

5.11e-04117353M39300
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 FNDC1 LDLRAD3 VCAN NOTCH3

9.25e-09196356fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 FNDC1 LDLRAD3 VCAN NOTCH3

9.25e-09196356802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCellControl_saline-Mesenchymal_myocytic|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 PCSK5 COL5A2 FNDC1 VCAN NOTCH3

1.04e-082003565ed4261157cd51109b314818133ac3a0d34ee5fa
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KAZN RAB11FIP4 EPCAM NOTCH3

2.41e-07174355b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

AKAP6 COL5A2 THSD7B VCAN NOTCH3

2.86e-07180355d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL5A2 FNDC1 FIBIN VCAN C16orf89

2.93e-07181355e1ae9ada60ec89e7a7cde9c231c1a099ed2ffecc
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 COL5A2 FNDC1 FIBIN VCAN

3.02e-071823553dfa9187e9d2bab1d199079d29209c4648220ada
ToppCellLA-01._Fibroblast_I|World / Chamber and Cluster_Paper

LRP1 PCSK5 COL5A2 KAZN VCAN

3.45e-071873554ea486991f66c29728d127171a07b81404ec0b78
ToppCellE16.5-samps-Mesenchymal|E16.5-samps / Age Group, Lineage, Cell class and subclass

LRP1 COL5A2 MACF1 FIBIN VCAN

3.54e-071883553f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

COL5A2 FNDC1 FIBIN VCAN NOTCH3

3.54e-0718835514bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellE18.5-samps-Mesenchymal|E18.5-samps / Age Group, Lineage, Cell class and subclass

LRP1 COL5A2 MACF1 FIBIN VCAN

3.64e-071893550c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCellP07-Mesenchymal-mesenchymal_fibroblast|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 COL5A2 MACF1 FIBIN VCAN

3.83e-07191355a05e9a7eb137d804570dd7d8905975d735738767
ToppCellfacs-Heart-LV-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 FNDC1 FIBIN VCAN NOTCH3

3.83e-07191355b7a57691a4742070cee640e285c1f4d0da95baf1
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FNDC1 FIBIN VCAN NOTCH3

3.83e-071913551efb47743b6834b64cb0f61721ddbe875b1a66ca
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 FIBIN VCAN

3.93e-07192355671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCellCOVID-19-Heart-Fib_+_EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

LRP1 PCSK5 COL5A2 LDLRAD3 VCAN

3.93e-0719235560b1312e84f6d6448365a952469c506c00b5fe93
ToppCellfacs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 FIBIN VCAN

3.93e-07192355840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.03e-0719335549600db68ed65cafc67bd45a285b364e4f5f88af
ToppCellfacs-Diaphragm-Limb_Muscle-3m-Mesenchymal-mesenchymal_stem_cell|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.03e-07193355160691b671710be10220803d788c2c961c236af1
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.03e-0719335545b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellLA-02._Fibroblast_II|LA / Chamber and Cluster_Paper

LRP1 PCSK5 COL5A2 KAZN VCAN

4.14e-07194355234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 FNDC1 LDLRAD3 VCAN NOTCH3

4.14e-07194355ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP1 PCSK5 COL5A2 FIBIN VCAN

4.24e-07195355f54bc4454270ff06e85596f98199372b50d0179f
ToppCellCOVID-19-Heart-Fib_1|Heart / Disease (COVID-19 only), tissue and cell type

LRP1 COL5A2 KAZN LDLRAD3 VCAN

4.24e-07195355f423baa36ac7cdc383c033e35a7d17e6bf913323
ToppCellP07-Mesenchymal|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.24e-07195355859764b605866b6c3e6edd0698670ca9c0f20745
ToppCellLA-02._Fibroblast_II|World / Chamber and Cluster_Paper

LRP1 PCSK5 COL5A2 KAZN VCAN

4.24e-07195355a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCellP03-Mesenchymal|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 COL5A2 MACF1 FIBIN VCAN

4.24e-071953556180309c6ae278b996fd98c57461cbc129c028ba
ToppCell15-Trachea-Mesenchymal|Trachea / Age, Tissue, Lineage and Cell class

COL5A2 FNDC1 THSD7B FIBIN VCAN

4.35e-071963557e178c76285e61c721c38d7a995ebf89dc428f9f
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 LEFTY1 FIBIN VCAN

4.35e-0719635559b5b5a0c123d0423abd19c312514849004b903b
ToppCellE18.5-Mesenchymal-Mesenchymal_structural|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 COL5A2 MACF1 FIBIN VCAN

4.35e-0719635597e26622d9582b092c18ff5b7e957818f99d9631
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP1 COL5A2 MACF1 FIBIN VCAN

4.35e-07196355f429f045ba45e24717963315832150b12a115bfa
ToppCelldroplet-Heart-HEART-1m-Mesenchymal-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 LEFTY1 FIBIN VCAN

4.46e-07197355b16add329bb35a558287ede51353010dde5bc029
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

LRP1 COL5A2 MACF1 KAZN VCAN

4.46e-0719735531a1852911bda38543916585fda34255fd62a134
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 PCSK5 FNDC1 VCAN NOTCH3

4.46e-071973555afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 PCSK5 FNDC1 VCAN NOTCH3

4.46e-071973551baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

LRP1 PCSK5 FNDC1 VCAN NOTCH3

4.46e-07197355b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.58e-071983550a4b19c3d5e65ecd24fc2ce80ac5276c813282c7
ToppCelltumor_Lung-Fibroblasts-Myofibroblasts|tumor_Lung / Location, Cell class and cell subclass

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.58e-0719835531f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.69e-0719935584545ced0c792bc77980a50d65e484eab648d47e
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.69e-07199355c2c42ecf20d1924edc2f899c01dfa5fcf3c210b9
ToppCelldroplet-Limb_Muscle-nan-3m-Mesenchymal-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 PCSK5 COL5A2 FNDC1 FIBIN

4.69e-07199355edd5300da1a3b758210ff8f949e9d1988b8bc7e2
ToppCell(2)_Fibroblasts|World / Cell class and subclass of bone marrow stroma cells in homeostatis

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.69e-07199355777423b413376b0d3fbd92ff51dd0133fb54d293
ToppCellILEUM-inflamed-(8)_Fibroblast|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.69e-07199355cb3c04b91c8e8080137823b11c76ca0a2adda52d
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

LRP1 PCSK5 FIBIN VCAN C16orf89

4.69e-07199355f19c683f38bca3bfee40396f27423441051dec67
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 COL5A2 KAZN LDLRAD3 VCAN

4.69e-07199355abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCellControl_saline-Mesenchymal_fibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.81e-0720035564ae5cf6cb4fc94cf1052abd82648f6b8e6445fe
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 PCSK5 COL5A2 FNDC1 VCAN

4.81e-072003559d5b3c2dcfa55d50acc2ce2c319d51aa525d4cd1
ToppCellControl_saline-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 PCSK5 COL5A2 FNDC1 VCAN

4.81e-07200355a799fc7bb83ad0524362cb5010df949741fb7bf3
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.81e-072003553dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.81e-0720035544a68bacdb3d5bf563bd35952176995850933a81
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 COL5A2 FNDC1 VCAN C16orf89

4.81e-072003553a164e3971bcd62b148b813171c103adb81f972e
ToppCellTracheal-10x5prime-Stromal-Fibroblastic-Fibro_adventitial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 PCSK5 COL5A2 FIBIN VCAN

4.81e-0720035574ad0ae592252060ee294d7483327d765a6ba1dd
ToppCellControl_saline-Mesenchymal_fibroblastic-Fibroblasts|Control_saline / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.81e-07200355a1fc74c1b27e104895910bc7cdce7ba33d30df7e
ToppCellLPS_IL1RA_TNF-Mesenchymal_fibroblastic|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LRP1 COL5A2 MACF1 FIBIN VCAN

4.81e-07200355dc61016c61729f69649cfb21f6264e685ce83dea
ToppCellTracheal-10x5prime-Stromal-Fibroblastic|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 PCSK5 COL5A2 FIBIN VCAN

4.81e-072003557ba292c30d915e66ebc8026fa76492cedf64700e
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 COL5A2 FNDC1 FIBIN VCAN

4.81e-07200355ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCellTracheal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LRP1 PCSK5 COL5A2 FIBIN VCAN

4.81e-07200355920e6036c0a9c0089d0d898673daf9dd9d7279fc
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 FNDC1 VCAN NOTCH3

9.62e-06171354b0373ed8283ee1792b6a490bff93906546978593
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 FNDC1 VCAN NOTCH3

9.62e-06171354b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 KAZN EPCAM NOTCH3

1.03e-05174354a9f34d1237f335d27c5560ff514368f4709f9144
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 KAZN EPCAM NOTCH3

1.03e-051743540fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-Smooth_muscle_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

LEFTY2 THSD7B FIBIN NOTCH3

1.05e-05175354fed9e4120c758fdcc23bb248d1801002b0e0d485
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 KAZN EPCAM NOTCH3

1.08e-05176354d43d9e86c4d4fa1e88fbf2b899ac7143717aac90
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.10e-051773544943d040eee0f9dceaddc7498171281d170e271f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.10e-051773543f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCelldroplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COPG2 KAZN LMTK3 ADAM23

1.10e-051773548ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

LEFTY2 LMTK3 FIBIN C16orf89

1.13e-051783549a3ef66814dfca7b37024e7f79e86ea8c72ae10f
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6|TCGA-Ovary / Sample_Type by Project: Shred V9

LRP1 COL5A2 FNDC1 VCAN

1.13e-05178354142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LEFTY2 LMTK3 FIBIN C16orf89

1.13e-05178354b413a634283550fa224db7d0d05956e3f64694a1
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LEFTY2 LMTK3 FIBIN C16orf89

1.13e-0517835449a2271718637522f74334068d252963ee13b1ce
ToppCellBAL-Severe-Epithelial-Epithelial-undefined_Epi|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

LEFTY2 LMTK3 FIBIN C16orf89

1.13e-0517835419b5432aa1d7f616d58a106543c18cf2d7ca840c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 FNDC1 VCAN

1.15e-0517935468ccfe66474d049a926afc21bffa231446becc69
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 FNDC1 VCAN

1.20e-05181354c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 FNDC1 VCAN

1.20e-05181354c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell21-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high|Trachea / Age, Tissue, Lineage and Cell class

LEFTY2 COL5A2 FNDC1 FIBIN

1.23e-05182354354dcdb01360597f68c4fe157a682aee1c0b8bb1
ToppCellPND07-28-samps-Epithelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

LRRIQ1 EPCAM SNX25 C16orf89

1.26e-05183354a98f1d71d82ed6cca996f74352ab834fb6e95206
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 COL5A2 LRRIQ1 C16orf89

1.28e-05184354f506d0ee48f39d6f59f19554217dfdf0987cc405
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PCSK5 COL5A2 LRRIQ1 C16orf89

1.28e-051843548bcb1c4bc8ffef74338cdade926a94711de93c64
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-4|TCGA-Bladder / Sample_Type by Project: Shred V9

LEFTY2 FNDC1 FIBIN VCAN

1.31e-05185354e1f3f0e974eb3fe1c05018beb9e124c7fb0cbe50
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FNDC1 ADAM23 FIBIN VCAN

1.31e-05185354ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCellP15-Mesenchymal-mesenchymal_fibroblast|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP1 COL5A2 MACF1 FIBIN

1.31e-0518535446460e74cc613df9043f5404e7342aa13cc34873
ToppCellControl-Fibroblasts-Pathological_FB|Control / group, cell type (main and fine annotations)

COL5A2 FNDC1 VCAN NOTCH3

1.37e-05187354b7280b8baa0fba9c2b4bff660c240ed96f6ff9b7
ToppCellCOVID-19-Fibroblasts-Airway_smooth_muscle|COVID-19 / group, cell type (main and fine annotations)

AKAP6 COL5A2 VCAN NOTCH3

1.37e-05187354464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.37e-05187354ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.37e-0518735448bfdb3504c3fefe5db3abac4b790c369680ab4e
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 FNDC1 FIBIN VCAN

1.37e-051873544e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 FNDC1 FIBIN VCAN

1.37e-05187354d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL5A2 FNDC1 FIBIN VCAN

1.37e-05187354827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.37e-05187354530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.37e-05187354958402fcc78f4c7a7d13d659d776f3817137975f
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

LRP1 COL5A2 LDLRAD3 FIBIN

1.40e-05188354fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell(2)_Fibroblasts-(20)_Fibro-1|World / Cell class and subclass of bone marrow stroma cells in homeostatis

LRP1 COL5A2 FNDC1 VCAN

1.40e-05188354409a7b69d02e87084ca955e3fe6c77230dee8861
ToppCellhuman_hepatoblastoma-Tumor_cells-T5|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

COPG2 LDLRAD3 ADAM23 VCAN

1.40e-05188354b070a0667f1ee9b825b267b6c389b7c42fc436f9
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP1 KAZN LDLRAD3 FIBIN

1.43e-05189354f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast|PND07-28-samps / Age Group, Lineage, Cell class and subclass

COL5A2 MACF1 FIBIN VCAN

1.43e-05189354dc5164591dea45b420798b94dda211be03daa70c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL5A2 THSD7B LDLRAD3 NOTCH3

1.43e-05189354fac5c291a9a87418bb0878c3d624829bdbf1f428
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP1 COL5A2 LDLRAD3 VCAN

1.43e-05189354c734e5693808a0333139e87bd5be2597a9252afe
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LRP1 PCSK5 FNDC1 NOTCH3

1.43e-0518935445e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCelldroplet-Mammary_Gland-nan-3m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 COL5A2 FNDC1 VCAN

1.46e-05190354bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP1 FNDC1 KAZN VCAN

1.46e-05190354990ac07f4b0a22041daac7502f74fafd6d258cba
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

COL5A2 FNDC1 VCAN

2.56e-0450273GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_1
Drug(-)-Isoproterenol hydrochloride [5984-95-2]; Up 200; 16.2uM; HL60; HT_HG-U133A

PCSK5 ZER1 LAT DNAJA4 VCAN

4.97e-061643556149_UP
Diseasecolorectal cancer

AKAP6 LRP1 MACF1 NAA25 KAZN VCAN

7.03e-05604356MONDO_0005575
DiseaseMigraine Disorders

LRP1 NOTCH3

1.06e-0413352C0149931
Diseasecortical thickness

AKAP6 LRP1 COL5A2 MACF1 RAB11FIP4 LRRIQ1 VCAN

2.84e-041113357EFO_0004840
Diseaseinflammatory bowel disease (implicated_via_orthology)

MST1 MST1L

4.03e-0425352DOID:0050589 (implicated_via_orthology)
DiseaseCFTR mutation carrier status

PCSK5 THSD7B

4.03e-0425352EFO_0021794
Diseasejoint hypermobility measurement

FNDC1 VCAN

7.05e-0433352EFO_0007905
Diseaseblood molybdenum measurement

AKAP6 NAA25

9.35e-0438352EFO_0007582
DiseaseMalignant neoplasm of breast

AKAP6 MST1 MACF1 NAA25 KLHDC10 NOTCH3

1.51e-031074356C0006142
Diseasedisease recurrence, colon carcinoma

MACF1 THSD7B

1.68e-0351352EFO_0004952, EFO_1001950
DiseaseFamilial thoracic aortic aneurysm and aortic dissection

COL5A2 VCAN

1.81e-0353352C4707243
Diseaseoptic disc size measurement

MACF1 LRRIQ1 VCAN

1.84e-03205353EFO_0004832
DiseaseAlzheimer's disease (implicated_via_orthology)

LRP1 DNAJA4

2.09e-0357352DOID:10652 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
GALQNNDGLYDPDCD

EPCAM

86

P16422
NDGLYDPDCDESGLF

EPCAM

91

P16422
QQEGCFGEPDAEDEE

C16orf89

281

Q6UX73
EPTECGNGYVEAGEE

ADAM23

501

O75077
VPGYSGDQCELDFDE

VCAN

3116

P13611
AEGDVGDYRCPQDQS

GZF1

251

Q9H116
YEEDEDGPQAGVQCQ

DNAJA4

381

Q8WW22
FEDYGEGDDVDCAPS

RAB11FIP4

216

Q86YS3
QAEEEEPFQDGTYDC

RIC1

1406

Q4ADV7
CNGFEDCPDGSDEEN

LDLRAD3

91

Q86YD5
DYGSLQNEDCGDDDP

KAZN

741

Q674X7
DLGDYGAQGDCDPEA

LEFTY1

241

O75610
LDQGLDDNYCRNPDG

MST1L

201

Q2TV78
CEDADEDEDDYHNPG

LAT

146

O43561
QDNCGDGEDERDCPE

LRP1

3436

Q07954
EFENPEGEDCSGEYT

LMTK3

71

Q96Q04
ECGQGEVQDPDYEEC

PCSK5

1021

Q92824
NPDYDESGGPDNEDY

KLHDC10

111

Q6PID8
LPGYNGDNCEDDVDE

NOTCH3

1111

Q9UM47
GEEEDGYIEDCYVPQ

MACF1

21

O94854
EFPGADGCNQVDAEY

LCN15

76

Q6UWW0
PDDADINFGYCEVEE

LRRIQ1

151

Q96JM4
NGIPECYAEEDEFSG

FNDC1

1531

Q4ZHG4
EDEGYGEEIACTQNG

COL5A2

31

P05997
DCDPNTGVPDEDGYD

COPG2

731

Q9UBF2
DLRDYGAQGDCDPEA

LEFTY2

241

O00292
LDQGLDDNYCRNPDG

MST1

231

P26927
QLVGQENVCGDDYDE

CEP295

1901

Q9C0D2
GDYEENDDPEKCQLL

FIBIN

41

Q8TAL6
YDQQEDGALDEGEGP

SNX25

266

Q9H3E2
GTQEAGPEEYCQEEL

VHLL

16

Q6RSH7
GPEEYCQEELGAEEE

VHLL

21

Q6RSH7
SDDDEQEDPNDYCKG

SRPK1

51

Q96SB4
NEDPGYDEEADNHGG

AKAP6

1256

Q13023
NIFYEEENPGGCEDE

ZER1

141

Q7Z7L7
EAANGGQECPDTLYE

THSD7B

771

Q9C0I4
SQGCNDEYKLGDPEE

NAA25

336

Q14CX7