Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol monophosphate 1-phosphatase activity	IMPA2 INPP5F	3.84e-05	3	72	2	GO:0008934
GeneOntologyMolecularFunction	inositol monophosphate phosphatase activity	IMPA2 INPP5F	3.84e-05	3	72	2	GO:0052834
GeneOntologyMolecularFunction	inositol monophosphate 3-phosphatase activity	IMPA2 INPP5F	3.84e-05	3	72	2	GO:0052832
GeneOntologyMolecularFunction	inositol monophosphate 4-phosphatase activity	IMPA2 INPP5F	3.84e-05	3	72	2	GO:0052833
Domain	APCDDC	APCDD1 APCDD1L	1.51e-05	2	73	2	PF14921
Domain	APCDD1	APCDD1 APCDD1L	1.51e-05	2	73	2	IPR029405
Domain	APCDDC	APCDD1 APCDD1L	1.51e-05	2	73	2	SM01352
Domain	Cullin_homology	ANAPC2 CUL7	5.33e-04	9	73	2	IPR016158
Domain	Cullin	ANAPC2 CUL7	6.64e-04	10	73	2	PF00888
Domain	CULLIN_2	ANAPC2 CUL7	6.64e-04	10	73	2	PS50069
Domain	Cullin_N	ANAPC2 CUL7	6.64e-04	10	73	2	IPR001373
Domain	CULLIN_1	ANAPC2 CUL7	6.64e-04	10	73	2	PS01256
Domain	ARM-type_fold	DCAF1 GBF1 ZNFX1 CLASP2 CUL7 WDFY4	2.10e-03	339	73	6	IPR016024
Domain	RCC1	ALS2 HERC5	2.74e-03	20	73	2	PF00415
Domain	RCC1_1	ALS2 HERC5	3.02e-03	21	73	2	PS00625
Domain	RCC1_2	ALS2 HERC5	3.02e-03	21	73	2	PS00626
Domain	RCC1_3	ALS2 HERC5	3.02e-03	21	73	2	PS50012
Domain	Reg_chr_condens	ALS2 HERC5	3.31e-03	22	73	2	IPR000408
Domain	-	ALS2 HERC5	3.31e-03	22	73	2	2.130.10.30
Domain	RCC1/BLIP-II	ALS2 HERC5	3.61e-03	23	73	2	IPR009091
Domain	WD_REPEATS_1	DCAF1 WDR91 PWP2 TEP1 WDFY4	4.64e-03	278	73	5	PS00678
Domain	WD_REPEATS_2	DCAF1 WDR91 PWP2 TEP1 WDFY4	4.71e-03	279	73	5	PS50082
Domain	WD_REPEATS_REGION	DCAF1 WDR91 PWP2 TEP1 WDFY4	4.71e-03	279	73	5	PS50294
Domain	EGF_LAM_2	NTNG1 AGRN	6.11e-03	30	73	2	PS50027
Domain	EGF_LAM_1	NTNG1 AGRN	6.11e-03	30	73	2	PS01248
Domain	WD40_repeat_dom	DCAF1 WDR91 PWP2 TEP1 WDFY4	6.12e-03	297	73	5	IPR017986
Domain	LRRCT	LRRC24 TLR2	6.93e-03	32	73	2	PF01463
Pubmed	Drapc1 expression during mouse embryonic development.	APCDD1 APCDD1L	4.47e-06	2	74	2	15465500
Pubmed	Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.	SCN5A CLASP2	1.34e-05	3	74	2	34092082
Pubmed	The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins.	SUPT6H SUZ12	1.34e-05	3	74	2	29033324
Pubmed	Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.	CLASP2 AGRN	2.67e-05	4	74	2	22851317
Pubmed	FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest.	ANAPC2 CUL7	4.45e-05	5	74	2	21135578
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	DCAF1 WDR91 SUPT6H MED23	6.10e-05	99	74	4	34161765
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TANC2 ZFYVE28 ALS2 WDFY4	6.59e-05	101	74	4	10997877
Pubmed	CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis.	GDF15 TLR2	6.66e-05	6	74	2	32424099
Pubmed	Tagging genes with cassette-exchange sites.	TIPIN CYB5R3 NTNG1 CLASP2 MED23 PRDM5	8.16e-05	335	74	6	15741177
Pubmed	Novel Cul3 binding proteins function to remodel E3 ligase complexes.	WDR91 PWP2 WDFY4	8.63e-05	40	74	3	25011449
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 GBF1 LRRC24 SCN5A CLASP2 NCLN FHIP1B TEP1 AGRN MFSD12	1.14e-04	1105	74	10	35748872
Pubmed	An intrinsic distinction in neuromuscular junction assembly and maintenance in different skeletal muscles.	ITGA7 AGRN	2.43e-04	11	74	2	11988168
Pubmed	Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.	GBF1 SCN5A NME7	2.49e-04	57	74	3	24952745
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TANC2 GBF1 CLASP2 CUL7 INPP5F NME7	3.82e-04	446	74	6	24255178
Pubmed	A protein interaction landscape of breast cancer.	RAD51C DCAF1 HNRNPDL GBF1 GDF15 SUZ12 CUL7	4.05e-04	634	74	7	34591612
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TANC2 VPS33A ADAM30 ZNFX1 NCLN PRDM5 DNAH7	4.20e-04	638	74	7	31182584
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	DCAF1 CLCN6 SUPT6H ANAPC2 CUL7 NME7 AGRN	4.24e-04	639	74	7	23443559
Pubmed	Patterns of laminins and integrins in the embryonic ventricular zone of the CNS.	ITGA7 AGRN	5.26e-04	16	74	2	17948866
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TANC2 GBF1 NTNG1 KCNS2 CUL7 WDFY4	6.46e-04	493	74	6	15368895
Pubmed	CRL7SMU1 E3 ligase complex-driven H2B ubiquitylation functions in sister chromatid cohesion by regulating SMC1 expression.	DCAF1 CUL7	6.68e-04	18	74	2	29507117
Pubmed	Toll-like receptor signaling pathway variants and prostate cancer mortality.	GDF15 TLR2	7.46e-04	19	74	2	19505919
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	HNRNPDL GBF1 SUPT6H PWP2 CYB5R3 CC2D2A CLASP2 SUZ12 NCLN MED23	8.54e-04	1425	74	10	30948266
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	ANAPC2 CUL7 HERC5	9.51e-04	90	74	3	35671810
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	DCAF1 GBF1 P4HTM CYB5R3 METAP1D NCLN MED23 TMEM205 HSDL1	1.01e-03	1203	74	9	29180619
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	SUPT6H NCLN NME7 HERC5	1.11e-03	212	74	4	33462405
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	PWP2 CUL7 TEP1 HERC5	1.15e-03	214	74	4	22199357
Pubmed	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	HNRNPDL TANC2 GBF1	1.18e-03	97	74	3	22360420
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	ANAPC2 CUL7	1.20e-03	24	74	2	33705438
Pubmed	Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	NTNG1 INPP5F DNAH7	1.36e-03	102	74	3	10231032
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	HNRNPDL GBF1 VPS33A SUZ12	1.54e-03	232	74	4	25515538
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DCAF1 SUPT6H AGRN HERC5	2.05e-03	251	74	4	28077445
Pubmed	Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.	TINF2 SUZ12	2.13e-03	32	74	2	21460039
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|368C / Donor, Lineage, Cell class and subclass (all cells)	GBF1 GDF15 DDX60L CUL7 NCLN MED23 WDFY4 MFSD12	6.18e-10	178	74	8	536a601abcc60867949ea06e9aafb6c7b799b56b
Disease	growth differentiation factor 15 measurement	GDF15 WDFY4	1.22e-04	7	72	2	EFO_0009181
Disease	hemoglobin A1 measurement	DCAF1 LRRC66 GDF15 CYB5R3 VHLL ADAM30	1.70e-03	520	72	6	EFO_0007629
Disease	blood cobalt measurement	NTNG1 CC2D2A PRDM5	1.96e-03	101	72	3	EFO_0007577

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLLHQFSFSPEREIR	ANAPC2	526	Q9UJX6
EILNTLFFLPIRRLH	ALS2	831	Q96Q42
PTLRAYHTLRLALEF	AGRN	1386	O00468
VRPAVLFLTRLFTFH	APCDD1L	291	Q8NCL9
LISLHQPRSDIFRLF	ABCG8	266	Q9H221
ALLDAVSSFRIRHRP	NPR2	936	P20594
NFLRSLPTLHERFRL	ADGRG7	761	Q96K78
SPIRRFADVLVHRLL	DIS3L2	701	Q8IYB7
RDHFIRTLSLKPLLF	P4HTM	131	Q9NXG6
FPFRHDLDDLSLRTR	RAD51C	246	O43502
EIISHDTRRFRFALP	CYB5R3	51	P00387
RRPDLFRRHFKSSSI	HNRNPDL	81	O14979
EHERFAIRRLPAFTL	NCLN	371	Q969V3
ALFRTPFSLQRHLLI	PRDM5	411	Q9NQX1
LFRPFHTLLRKIRDL	ZFYVE28	256	Q9HCC9
RLIRTIAAIRSFPHD	ASB8	21	Q9H765
GFRVRPELHILLFLL	OR9K2	41	Q8NGE7
LLFSRLVPFVHREGT	FHIP1B	211	Q8N612
FDRHLIFSRFRPISV	DCAF1	1071	Q9Y4B6
FIIFSIRHEIRRIDL	LRP1B	1261	Q9NZR2
FFRRQRDISHSIVLP	METAP1D	41	Q6UB28
KSFPLRTTRRHFLRQ	DDX60L	411	Q5H9U9
GPAFFSRVRRLTHLL	CUL7	1086	Q14999
FKRRLRSHTLLRFPE	KCNS2	26	Q9ULS6
LRFLPVFDIVIHRFL	MED23	961	Q9ULK4
RLLDFTFLHLPRLQE	LRRC24	136	Q50LG9
EASRLHRALFRLSPT	GDF15	116	Q99988
ISELRERFPSHRFIA	IMPA2	66	O14732
VKRHRSSFRNRFPLL	LRRC66	136	Q68CR7
ALRPTFDLTVRRNHL	HERC5	676	Q9UII4
PFHILRVIRIESRLL	OXGR1	256	Q96P68
SFHVDRVLGLRRSLP	GASK1A	331	Q9UFP1
RLLLPRHLRVFSFTE	ADAM30	81	Q9UKF2
FRPLTFHGLILRSQL	CLCN6	736	P51797
FRLLHLRSQEVPEFR	CC2D2A	911	Q9P2K1
FRFAIEHISRISRIL	DNAH7	2316	Q8WXX0
EVRPEVLFLTRHFIF	APCDD1	301	Q8J025
VLALTLLRFRVLPDH	CYP4F2	481	P78329
LDLLLEHRLRSVAFP	MACROD1	251	Q9BQ69
ELFRFLISLTNPHDR	GBF1	406	Q92538
LADTAVLFRARPILH	ITGA7	506	Q13683
SLIRLHFIPRLGSRA	HSDL1	46	Q3SXM5
DIHPRFLVALISRRS	INPP5F	271	Q9Y2H2
FSLLFHLGTRERRRP	MFSD12	231	Q6NUT3
EIARHLRPGTLRAIF	NME7	331	Q9Y5B8
FFTVTDLRIRLLRPA	NTNG1	256	Q9Y2I2
LLFRSLPRHTFGLVQ	TMEM205	36	Q6UW68
FFSPTLFRVIRLARI	SCN5A	1616	Q14524
ITKLLPFHRIFLDRL	TANC2	586	Q9HCD6
LTLLPGRDFRIHNFR	VHLL	81	Q6RSH7
SLHFLLLFRGLLEPR	CHRD	311	Q9H2X0
VPVRRRSFEFLDLLL	CLASP2	226	O75122
TDFLRLPHFTKRRTA	SUPT6H	806	Q7KZ85
LTHTPILRDFFLSDR	USP27X	96	A6NNY8
FAFLVTLPRRLLVDR	TMC8	441	Q8IU68
PRILVLHLNRFSASR	USP21	456	Q9UK80
RPLYLRLVTDHLRLF	TEP1	1361	Q99973
LHERLQDLKSRFRFP	NIBAN1	416	Q9BZQ8
SALHFEVFRVALRPR	SH2D3A	56	Q9BRG2
SRHFKPEIRVTSLRF	PWP2	696	Q15269
FPRVLEFLRSLRAVA	TINF2	31	Q9BSI4
RTRNLIAPIFLHRTL	SUZ12	101	Q15022
FVFSLLGLVHRRDPR	TMEM102	66	Q8N9M5
RFLTLVRHLARTEQP	WDFY4	1091	Q6ZS81
LRISVYFPTLRHEIL	RRN3P2	206	A6NIE6
THFRLLREDFVRPLR	ZNFX1	371	Q9P2E3
SSVGHLVRLPRAFRL	ZPBP	41	Q9BS86
TDLFIRFPENLLLHR	ZSWIM3	211	Q96MP5
FLLHLLVRRSRFVLF	SLC29A4	246	Q7RTT9
LRLSPAQLHFLFLRE	TSPEAR	121	Q8WU66
TRDFHILFVPRRSLL	VPS33A	106	Q96AX1
TLTIRRLHIPRFYLF	TLR2	311	O60603
RLFSRLEDIYRPTIH	WDR91	71	A4D1P6
RLISERGLPALRHVF	TIPIN	71	Q9BVW5