Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	cytoplasmic dynein complex	DCTN1 DYNC1LI2	4.69e-04	24	28	2	GO:0005868
GeneOntologyCellularComponent	dynein complex	DCTN1 DYNC1LI2	2.37e-03	54	28	2	GO:0030286
Domain	PI3Ka	PIK3C2A PI4KA	7.20e-05	9	27	2	PF00613
Domain	-	PIK3C2A PI4KA	7.20e-05	9	27	2	1.25.40.70
Domain	PI3Ka	PIK3C2A PI4KA	7.20e-05	9	27	2	SM00145
Domain	PIK_HELICAL	PIK3C2A PI4KA	8.99e-05	10	27	2	PS51545
Domain	PI_Kinase	PIK3C2A PI4KA	8.99e-05	10	27	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PI4KA	8.99e-05	10	27	2	IPR001263
Domain	PI3/4_kinase_CS	PIK3C2A PI4KA	2.09e-04	15	27	2	IPR018936
Domain	PI3Kc	PIK3C2A PI4KA	2.39e-04	16	27	2	SM00146
Domain	-	PIK3C2A PI4KA	2.39e-04	16	27	2	1.10.1070.11
Domain	PI3_4_KINASE_1	PIK3C2A PI4KA	3.04e-04	18	27	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A PI4KA	3.04e-04	18	27	2	PS00916
Domain	PI3/4_kinase_cat_dom	PIK3C2A PI4KA	3.04e-04	18	27	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A PI4KA	3.04e-04	18	27	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A PI4KA	3.04e-04	18	27	2	PS50290
Domain	ARM-type_fold	PPP2R5D PIK3C2A PI4KA DOCK9	1.35e-03	339	27	4	IPR016024
Domain	Helicase_C	DDX20 INO80	1.04e-02	107	27	2	PF00271
Domain	HELICc	DDX20 INO80	1.04e-02	107	27	2	SM00490
Domain	Helicase_C	DDX20 INO80	1.06e-02	108	27	2	IPR001650
Domain	HELICASE_CTER	DDX20 INO80	1.08e-02	109	27	2	PS51194
Domain	HELICASE_ATP_BIND_1	DDX20 INO80	1.08e-02	109	27	2	PS51192
Domain	DEXDc	DDX20 INO80	1.08e-02	109	27	2	SM00487
Domain	Helicase_ATP-bd	DDX20 INO80	1.10e-02	110	27	2	IPR014001
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	BLMH UBR2 PPP2R5D PTPRC DCTN1 ITGB1 DYNC1LI2	1.41e-04	719	24	7	MM14540
Pathway	REACTOME_ADAPTIVE_IMMUNE_SYSTEM	BLMH UBR2 PPP2R5D PTPRC DCTN1 ITGB1 DYNC1LI2	3.37e-04	828	24	7	M1058
Pathway	WP_CELLS_AND_MOLECULES_INVOLVED_IN_LOCAL_ACUTE_INFLAMMATORY_RESPONSE	C5 ITGB1	3.72e-04	17	24	2	M39733
Pathway	BIOCARTA_LAIR_PATHWAY	C5 ITGB1	3.72e-04	17	24	2	M3952
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE	PIK3C2A PI4KA	4.18e-04	18	24	2	M645
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE	PIK3C2A PI4KA	4.18e-04	18	24	2	MM14642
Pathway	REACTOME_OTHER_SEMAPHORIN_INTERACTIONS	PTPRC ITGB1	4.67e-04	19	24	2	M10959
Pubmed	Mapping of the gene coding for the muscle protein nebulin (Neb) to the proximal region of mouse chromosome 2.	C5 NEB	6.25e-07	2	28	2	1683831
Pubmed	IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.	IGSF10 ITGB1	1.87e-06	3	28	2	38622980
Pubmed	Defining the membrane proteome of NK cells.	DDX20 PTPRC PIK3C2A DCTN1 ITGB1 PI4KA DOCK9 DYNC1LI2	2.70e-06	1168	28	8	19946888
Pubmed	Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.	PI4KA PITPNA	3.75e-06	4	28	2	7761838
Pubmed	Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA.	C5 NEB	3.75e-06	4	28	2	10964517
Pubmed	Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.	C5 NEB	6.24e-06	5	28	2	1679748
Pubmed	His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia.	C5 NEB	6.24e-06	5	28	2	1682866
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	NEB DCTN1 DYNC1LI2	7.40e-06	47	28	3	8812413
Pubmed	Tetraspanin CD81 is linked to ERK/MAPKinase signaling by Shc in liver tumor cells.	ITGB1 PI4KA	9.36e-06	6	28	2	14676841
Pubmed	Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6.	ITGB1 PI4KA	1.31e-05	7	28	2	9360995
Pubmed	Strain distribution pattern for SSLP markers in the SWXJ recombinant inbred strain set: chromosomes 1 to 6.	C5 PTPRC	1.31e-05	7	28	2	8747926
Pubmed	Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances.	PTPRC ITGB1	1.74e-05	8	28	2	27128622
Pubmed	The identification of a nonclassical cadherin expressed during B cell development and its interaction with surrogate light chain.	PTPRC ITGB1	1.74e-05	8	28	2	10906147
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	INO80 PTPRC DCTN1 ITGB1 PI4KA DOCK9 DYNC1LI2	1.87e-05	1084	28	7	11544199
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	NEB PIK3C2A DCTN1 ITGB1 DOCK9	4.37e-05	497	28	5	23414517
Pubmed	Interspecific backcross mice show sex-specific differences in allelic inheritance.	C5 NEB	6.52e-05	15	28	2	1916246
Pubmed	Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.	PTPRC ITGB1	7.45e-05	16	28	2	28218908
Pubmed	HIV-1 gp120-mediated apoptosis of T cells is regulated by the membrane tyrosine phosphatase CD45.	PTPRC PIK3C2A	7.45e-05	16	28	2	16524887
Pubmed	Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo.	PTPRC ITGB1	1.06e-04	19	28	2	28111199
Pubmed	Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.	PTPRC ITGB1	1.18e-04	20	28	2	30988302
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	C5 PTPRC	1.30e-04	21	28	2	4042679
Pubmed	Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.	PIK3C2A DCTN1	1.43e-04	22	28	2	26950368
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	DCTN1 DOCK9 DYNC1LI2	1.46e-04	127	28	3	30335684
Pubmed	Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.	DCTN1 DYNC1LI2	1.56e-04	23	28	2	36973253
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	BLMH UBR2 PPP2R5D PTPRC ITGB1 PI4KA	1.58e-04	1049	28	6	27880917
Pubmed	Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.	SAV1 DCTN1	2.01e-04	26	28	2	28720576
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE1A PIK3C2A	2.17e-04	27	28	2	11156964
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	SAV1 DDX20 PPP2R5D ITGB1 DYNC1LI2	2.70e-04	733	28	5	34672954
Pubmed	140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry.	PDE1A PI4KA DYNC1LI2	3.04e-04	163	28	3	16512683
Pubmed	The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.	C5 PTPRC	3.45e-04	34	28	2	1686571
Pubmed	Genetic composition of the recombinant congenic strains.	C5 PTPRC	5.03e-04	41	28	2	8903730
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	DDX20 INO80 NDUFB6 PI4KA	5.42e-04	475	28	4	31040226
Pubmed	Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis.	PTPRC ITGB1	5.53e-04	43	28	2	32294451
Cytoband	2q32.1	FSIP2 PDE1A	1.54e-04	30	28	2	2q32.1
Cytoband	6p21.1	UBR2 PPP2R5D	1.10e-03	80	28	2	6p21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q32	FSIP2 PDE1A	2.06e-03	110	28	2	chr2q32
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	PDE1A PIK3C2A DNASE1L3 DOCK9	5.71e-06	189	28	4	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PIK3C2A ITGB1 DNASE1L3 DOCK9	7.14e-06	200	28	4	3007583eaad3a5ae2df010513d3e4df59155123d
Drug	Flumetramide	SAV1 PIK3C2A	1.46e-06	2	28	2	CID000023512
Drug	paraldehyde	DCTN1 DYNC1LI2 PITPNA	8.07e-06	32	28	3	CID000031264
Drug	2-oxopropyl	BLMH PI4KA	3.05e-05	7	28	2	CID006432319
Drug	rhamnetin	BLMH SAV1	4.07e-05	8	28	2	CID005281691
Disease	virologic response measurement, response to abacavir	IGSF10 PIK3C2A	7.30e-04	42	28	2	EFO_0006905, EFO_0006906
Disease	response to efavirenz, virologic response measurement	IGSF10 PIK3C2A	1.39e-03	58	28	2	EFO_0006904, EFO_0006906
Disease	unipolar depression, alcohol dependence	NEB STEAP1B	2.49e-03	78	28	2	EFO_0003761, MONDO_0007079
Disease	lymphocyte percentage of leukocytes	UBR2 PTPRC STEAP1B SETD3	3.40e-03	665	28	4	EFO_0007993
Disease	albuminuria	EFNA1 STEAP1B	3.60e-03	94	28	2	EFO_0004285
Disease	coronary artery disease	IGSF10 PDE1A C5 INO80 DOCK9	4.86e-03	1194	28	5	EFO_0001645

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKAIKYYQHLYSIHL	DCTN1	721	Q14203
HKVKSLSVYHPQLAY	PPP2R5D	331	Q14738
LKQYYKVVNSYPLAH	DDX20	276	Q9UHI6
QYTHKIYHLQSKVPT	PITPNA	56	Q00169
SHYYDYPSIAHLVQK	ITGB1	311	P05556
FHISLKPYHISKFIY	INO80	831	Q9ULG1
YYYHIAKTLIKSAHN	NMBR	231	P28336
DLLYKYIVHKTYGFH	DYNC1LI2	281	O43237
QYKSLHDPHLKAYYK	FSIP2	96	Q5CZC0
TYHKKYNPDKHYIYV	PIK3C2A	1431	O00443
YSKYKNPYHNLIHAA	PDE1A	211	P54750
IIHYYMKYHVSEKPY	NDUFB6	81	O95139
PVLVKLYKYHSQYHT	PI4KA	516	P42356
YIHHSKLQEYIKTYA	FMO6P	81	O60774
YSIYRYIHVGKEKHP	IL20RA	271	Q9UHF4
SHLLSETPQLYYKYK	IGSF10	391	Q6WRI0
YKEKLVSVKRSYHYH	DNASE1L3	106	Q13609
KHTQPYTIYTNHLYV	DOCK9	631	Q9BZ29
IKDYLPKIHQHTSYV	C4orf45	26	Q96LM5
KEGHSYYYISKPIHQ	EFNA1	121	P20827
PYIDKITHYNYLILS	C5	491	P01031
PQHKYNKLYTVEYLS	BLMH	276	Q13867
KSLYHQYIPTFHVYN	SLC44A5	446	Q8NCS7
QYAYFYKVIQTHPHA	SETD3	216	Q86TU7
IHPLATSHQQYFYKI	STEAP1B	76	Q6NZ63
YYVDHTNKKAQYRHP	SAV1	251	Q9H4B6
REVYQHLAHYVPKIY	UBR2	36	Q8IWV8
PYTKYVLSLHAYIIA	PTPRC	451	P08575
TNVNYKQPLHHYTYL	NEB	1401	P20929