Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionADP transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.83e-07111194GO:0015217
GeneOntologyMolecularFunctionATP transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

1.15e-06141194GO:0005347
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1E CACNB3

1.15e-06141194GO:0008331
GeneOntologyMolecularFunctionATP:ADP antiporter activity

SLC25A4 SLC25A5 SLC25A6

2.05e-0651193GO:0005471
GeneOntologyMolecularFunctionpurine ribonucleotide transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

9.73e-06231194GO:0005346
GeneOntologyMolecularFunctionadenine nucleotide transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

1.62e-05261194GO:0000295
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

1.69e-0591193GO:0099511
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels

CACNA1A CACNA1B CACNA1E

1.69e-0591193GO:0099626
GeneOntologyMolecularFunctionpurine nucleotide transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

2.54e-05291194GO:0015216
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity

HS3ST3B1 HS3ST3A1

3.52e-0521192GO:0033872
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

4.17e-0566411914GO:0008324
GeneOntologyMolecularFunctionnucleotide transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.29e-05331194GO:0015215
GeneOntologyMolecularFunctionorganophosphate ester transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

8.39e-05391194GO:0015605
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A

9.43e-0562711913GO:0022890
GeneOntologyMolecularFunctionalpha2-adrenergic receptor activity

ADRA2B ADRA2C

1.05e-0431192GO:0004938
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1A CACNA1B CACNA1E CACNB3

1.61e-04461194GO:0005245
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

2.16e-043431199GO:0005261
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

2.69e-0479311914GO:0015075
GeneOntologyMolecularFunctionadenine transmembrane transporter activity

SLC25A4 SLC25A5

3.48e-0451192GO:0015207
GeneOntologyMolecularFunctionfibroblast growth factor receptor activity

FGFR1 FGFR2

3.48e-0451192GO:0005007
GeneOntologyMolecularFunctionoxidative phosphorylation uncoupler activity

SLC25A4 SLC25A5

3.48e-0451192GO:0017077
GeneOntologyMolecularFunctioncarbohydrate derivative transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.24e-04591194GO:1901505
GeneOntologyMolecularFunctionnucleobase-containing compound transmembrane transporter activity

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.24e-04591194GO:0015932
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A

4.72e-0446511910GO:0046873
GeneOntologyMolecularFunctionepinephrine binding

ADRA2B ADRA2C

5.20e-0461192GO:0051379
GeneOntologyMolecularFunctionalpha-adrenergic receptor activity

ADRA2B ADRA2C

5.20e-0461192GO:0004936
GeneOntologyMolecularFunctionbitter taste receptor activity

TAS2R45 TAS2R30 TAS2R46

5.44e-04271193GO:0033038
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A

5.91e-0475811913GO:0015318
GeneOntologyMolecularFunction[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

HS3ST3B1 HS3ST3A1

7.25e-0471192GO:0008467
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN10A

7.82e-041821196GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN10A

8.28e-041841196GO:0022832
GeneOntologyMolecularFunctiontaste receptor activity

TAS2R45 TAS2R30 TAS2R46

9.88e-04331193GO:0008527
GeneOntologyMolecularFunctionRNA endonuclease activity

RPP30 RPP38 RCL1 SLFN11

1.28e-03791194GO:0004521
GeneOntologyMolecularFunctionpurine nucleobase transmembrane transporter activity

SLC25A4 SLC25A5

1.54e-03101192GO:0005345
GeneOntologyMolecularFunctionribonuclease P RNA binding

RPP30 RPP38

1.54e-03101192GO:0033204
GeneOntologyMolecularFunctionadrenergic receptor activity

ADRA2B ADRA2C

1.54e-03101192GO:0004935
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1A CACNA1B CACNA1E SLC25A41 CACNB3 SLC25A4 SLC25A5 SLC25A6 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

1.71e-03118011916GO:0022857
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

1.72e-034591199GO:0005216
GeneOntologyMolecularFunctionnucleobase transmembrane transporter activity

SLC25A4 SLC25A5

1.87e-03111192GO:0015205
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC25A4 SLC25A5 SLC25A6 SLC46A1 SLC34A3 SLC5A5 SLC6A4

2.00e-032961197GO:0015291
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4

2.18e-031521195GO:0022843
GeneOntologyMolecularFunctionribonuclease P activity

RPP30 RPP38

2.24e-03121192GO:0004526
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR51T1 NPBWR2 OR1D2 FZD9 ADRA2B ADRA2C P2RY2 OR4A16 OR6J1 TAS2R45 TAS2R30 TAS2R46 ADGRA3

2.36e-0388411913GO:0004930
GeneOntologyMolecularFunctioncatecholamine binding

ADRA2B ADRA2C

2.63e-03131192GO:1901338
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

OR51T1 NPBWR2 PECAM1 OR1D2 FZD9 LYVE1 ADRA2B ADRA2C P2RY2 OR4A16 OR6J1 FGFR1 FGFR2 TAS2R45 TAS2R30 TAS2R46 ADGRA3

2.73e-03135311917GO:0004888
GeneOntologyMolecularFunctionsodium ion binding

SLC6A4 SCN8A

3.06e-03141192GO:0031402
GeneOntologyMolecularFunctionheparan sulfate sulfotransferase activity

HS3ST3B1 HS3ST3A1

3.52e-03151192GO:0034483
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC34A3 SLC5A5 SLC6A4 SCN8A SCN10A

3.62e-031711195GO:0015081
GeneOntologyMolecularFunctiontransporter activity

CACNA1A CACNA1B CACNA1E SLC25A41 CACNB3 SLC25A4 SLC25A5 SLC25A6 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

4.12e-03128911916GO:0005215
GeneOntologyMolecularFunctionchannel activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

4.21e-035251199GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A CACNA1B CACNA1E CACNB3 SLC6A4 KCNQ4 SCN8A SCN10A UNC80

4.26e-035261199GO:0022803
GeneOntologyMolecularFunctiontRNA-specific ribonuclease activity

RPP30 RPP38

4.52e-03171192GO:0004549
GeneOntologyMolecularFunctioncysteine-type deubiquitinase activity

USP49 USP24 USP21 USP6

4.84e-031141194GO:0004843
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC46A1 SLC34A3 SLC5A5 SLC6A4

5.63e-031191194GO:0015294
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC5A5 SLC6A4

5.64e-03191192GO:0015373
GeneOntologyMolecularFunctiondeubiquitinase activity

USP49 USP24 USP21 USP6

6.50e-031241194GO:0101005
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1A CACNA1B CACNA1E CACNB3

7.45e-031291194GO:0005262
GeneOntologyBiologicalProcessmitochondrial ADP transmembrane transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.90e-0951174GO:0140021
GeneOntologyBiologicalProcessmitochondrial ATP transmembrane transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

6.76e-0881174GO:1990544
GeneOntologyBiologicalProcessADP transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.70e-07121174GO:0015866
GeneOntologyBiologicalProcessnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6 FZD9

1.28e-06151174GO:1901029
GeneOntologyBiologicalProcessnegative regulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6 FZD9

8.01e-06231174GO:0035795
GeneOntologyBiologicalProcessATP transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

8.01e-06231174GO:0015867
GeneOntologyBiologicalProcessregulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

SLC25A4 SLC25A5 SLC25A6 FZD9

9.57e-06241174GO:1901028
GeneOntologyBiologicalProcessnegative regulation of membrane permeability

SLC25A4 SLC25A5 SLC25A6 FZD9

1.33e-05261174GO:1905709
GeneOntologyBiologicalProcessnucleotide transmembrane transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

2.75e-05311174GO:1901679
GeneOntologyBiologicalProcessfibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development

FGFR1 FGFR2

3.19e-0521172GO:0035607
GeneOntologyBiologicalProcesscentral nervous system neuron differentiation

CACNA1A INHBA DCX OPHN1 DCLK2 FGFR1 FGFR2 DCLK1

3.37e-052171178GO:0021953
GeneOntologyBiologicalProcessforebrain generation of neurons

INHBA DCX DCLK2 FGFR1 FGFR2

3.39e-05651175GO:0021872
GeneOntologyBiologicalProcessmitochondrial outer membrane permeabilization

SLC25A4 SLC25A5 SLC25A6 FZD9

3.54e-05331174GO:0097345
GeneOntologyBiologicalProcessneuromuscular junction development

CACNB3 SORBS1 DNAJA3 FZD9 FGFR2

4.22e-05681175GO:0007528
GeneOntologyBiologicalProcesspyramidal neuron development

DCX DCLK2 FGFR2

4.88e-05131173GO:0021860
GeneOntologyBiologicalProcesspurine-containing compound transmembrane transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

7.68e-05401174GO:0072530
GeneOntologyBiologicalProcesspositive regulation of mitochondrial membrane permeability involved in apoptotic process

SLC25A4 SLC25A5 SLC25A6 FZD9

7.68e-05401174GO:1902110
GeneOntologyBiologicalProcesspurine ribonucleotide transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

7.68e-05401174GO:0015868
GeneOntologyBiologicalProcessmitochondrial outer membrane permeabilization involved in programmed cell death

SLC25A4 SLC25A5 SLC25A6 FZD9

9.32e-05421174GO:1902686
GeneOntologyBiologicalProcessadenine nucleotide transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

9.32e-05421174GO:0051503
GeneOntologyBiologicalProcessventricular zone neuroblast division

FGFR1 FGFR2

9.54e-0531172GO:0021847
GeneOntologyBiologicalProcessorbitofrontal cortex development

FGFR1 FGFR2

9.54e-0531172GO:0021769
GeneOntologyBiologicalProcesspurine nucleotide transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

1.12e-04441174GO:0015865
GeneOntologyBiologicalProcesspositive regulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6 FZD9

1.22e-04451174GO:0035794
GeneOntologyBiologicalProcesscell junction organization

CACNA1A CACNB3 CTTNBP2 RPS6 PECAM1 DOCK10 SORBS1 DCX LRIT3 OPHN1 DNAJA3 FZD9 FGFR1 FGFR2 DCLK1 CDH18

1.23e-0497411716GO:0034330
GeneOntologyBiologicalProcesssynapse organization

CACNA1A CACNB3 CTTNBP2 DOCK10 SORBS1 DCX LRIT3 OPHN1 DNAJA3 FZD9 FGFR1 FGFR2 DCLK1

1.39e-0468511713GO:0050808
GeneOntologyBiologicalProcesspyramidal neuron differentiation

DCX DCLK2 FGFR2

1.61e-04191173GO:0021859
GeneOntologyBiologicalProcessregulation of mitochondrial membrane permeability involved in apoptotic process

SLC25A4 SLC25A5 SLC25A6 FZD9

1.71e-04491174GO:1902108
GeneOntologyBiologicalProcessnucleotide transport

SLC25A41 SLC25A4 SLC25A5 SLC25A6

1.85e-04501174GO:0006862
GeneOntologyBiologicalProcesspositive regulation of membrane permeability

SLC25A4 SLC25A5 SLC25A6 FZD9

1.85e-04501174GO:1905710
GeneOntologyBiologicalProcessreceptor transactivation

ADRA2B ADRA2C

1.90e-0441172GO:0035624
GeneOntologyBiologicalProcessresponse to pain

CACNA1A CACNA1B CACNA1E SCN10A

2.00e-04511174GO:0048265
GeneOntologyBiologicalProcessskeletal muscle acetylcholine-gated channel clustering

SORBS1 DNAJA3 FZD9

2.20e-04211173GO:0071340
GeneOntologyBiologicalProcessforebrain neuron differentiation

INHBA DCX DCLK2 FGFR2

2.32e-04531174GO:0021879
GeneOntologyBiologicalProcessregulation of DNA-templated DNA replication

NUGGC MCM3 FGFR1 SLFN11

2.32e-04531174GO:0090329
GeneOntologyBiologicalProcesscalcium ion import

CACNA1A CACNA1B CACNA1E PLPP4 WNK3

2.40e-04981175GO:0070509
GeneOntologyBiologicalProcesscentral nervous system neuron development

DCX DCLK2 FGFR1 FGFR2 DCLK1

2.52e-04991175GO:0021954
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A UNC80 WNK3

2.85e-0494211715GO:0098655
GeneOntologyBiologicalProcessnegative regulation of catecholamine secretion

ADRA2B ADRA2C SYT11

2.90e-04231173GO:0033604
GeneOntologyBiologicalProcessnegative regulation of synaptic transmission, dopaminergic

SLC6A4 KCNQ4

3.15e-0451172GO:0032227
GeneOntologyBiologicalProcesssignal release

CACNA1A CACNA1B CACNA1E INHBA RFX6 SLC6A4 ADRA2B ADRA2C P2RY2 SYT11 TMF1 FGFR1

3.39e-0465311712GO:0023061
GeneOntologyBiologicalProcesssensory perception

OR51T1 CACNA1E CACNB3 COL11A2 LRIT3 OR1D2 OTOGL KCNQ4 OR4A16 OR6J1 SCN8A SCN10A FGFR1 TAS2R45 TAS2R30 TAS2R46

3.64e-04107211716GO:0007600
GeneOntologyBiologicalProcesscell junction assembly

CACNA1A RPS6 PECAM1 DOCK10 SORBS1 DCX LRIT3 OPHN1 FGFR1 DCLK1 CDH18

3.96e-0456911711GO:0034329
GeneOntologyBiologicalProcesspostsynapse organization

DOCK10 SORBS1 DCX OPHN1 DNAJA3 FZD9 FGFR1 DCLK1

4.19e-043131178GO:0099173
GeneOntologyBiologicalProcesssensory perception of mechanical stimulus

CACNB3 COL11A2 OTOGL KCNQ4 SCN8A SCN10A FGFR1

4.22e-042381177GO:0050954
GeneOntologyBiologicalProcessforebrain ventricular zone progenitor cell division

FGFR1 FGFR2

4.71e-0461172GO:0021869
GeneOntologyBiologicalProcessadenine transport

SLC25A4 SLC25A5

4.71e-0461172GO:0015853
GeneOntologyBiologicalProcessregulation of mitochondrial membrane permeability

SLC25A4 SLC25A5 SLC25A6 FZD9

5.40e-04661174GO:0046902
GeneOntologyBiologicalProcessregulation of neurotransmitter secretion

CACNA1A CACNA1B CACNA1E P2RY2 SYT11

5.66e-041181175GO:0046928
GeneOntologyBiologicalProcessregulation of secretion

CACNA1A CACNA1B CACNA1E INHBA RFX6 SLC6A4 ADRA2B ADRA2C P2RY2 SYT11 TMF1 FGFR1 WNK3

6.21e-0480111713GO:0051046
GeneOntologyBiologicalProcessmembrane depolarization

CACNA1A SLC6A4 FZD9 SCN8A SCN10A

6.35e-041211175GO:0051899
GeneOntologyBiologicalProcessforebrain neuron development

DCX DCLK2 FGFR2

6.46e-04301173GO:0021884
GeneOntologyBiologicalProcessforebrain neuroblast division

FGFR1 FGFR2

6.58e-0471172GO:0021873
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A WNK3

7.34e-0492211714GO:0098662
GeneOntologyBiologicalProcesssynaptic vesicle exocytosis

CACNA1A CACNA1B CACNA1E P2RY2 SYT11

7.35e-041251175GO:0016079
GeneOntologyBiologicalProcessbehavioral response to pain

CACNA1A CACNA1E SCN10A

7.83e-04321173GO:0048266
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1A CACNA1B CACNA1E CACNB3 SLC25A4 SLC25A5 SLC46A1 SLC34A3 SLC5A5 SLC6A4 KCNQ4 SCN8A SCN10A PLPP4 UNC80 WNK3

8.30e-04115711716GO:0006812
GeneOntologyBiologicalProcessmesodermal cell differentiation

INHBA FGFR1 FGFR2

1.02e-03351173GO:0048333
GeneOntologyBiologicalProcessregulation of secretion by cell

CACNA1A CACNA1B CACNA1E INHBA RFX6 SLC6A4 ADRA2B ADRA2C P2RY2 SYT11 TMF1 FGFR1

1.02e-0374011712GO:1903530
GeneOntologyCellularComponentcation channel complex

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN8A SCN10A UNC80

6.45e-052351208GO:0034703
GeneOntologyCellularComponentglutamatergic synapse

CACNA1A CACNA1B CTTNBP2 DOCK10 DCX OPHN1 FZD9 USP6 RGS14 ADRA2C P2RY2 SCN8A SCN10A FGFR1 DCLK1

6.92e-0581712015GO:0098978
GeneOntologyCellularComponentpostsynapse

CACNA1A CACNA1E CTTNBP2 DOCK10 RPS25 SH2D5 OPHN1 SLC6A4 DNAJA3 FZD9 USP6 RGS14 ADRA2C SYT11 SCN8A FGFR1 DCLK1

7.13e-05101812017GO:0098794
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1A CACNA1B CACNA1E CACNB3

1.40e-04461204GO:0005891
GeneOntologyCellularComponentsodium channel complex

SCN8A SCN10A UNC80

6.04e-04291203GO:0034706
GeneOntologyCellularComponentmitochondrial permeability transition pore complex

SLC25A4 SLC25A5

6.73e-0471202GO:0005757
GeneOntologyCellularComponentnucleolar ribonuclease P complex

RPP30 RPP38

6.73e-0471202GO:0005655
GeneOntologyCellularComponentcalcium channel complex

CACNA1A CACNA1B CACNA1E CACNB3

8.28e-04731204GO:0034704
GeneOntologyCellularComponentpresynaptic active zone membrane

CACNA1A P2RY2 SYT11 SCN8A

1.06e-03781204GO:0048787
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A CACNA1E SLC6A4 P2RY2 SYT11 SCN8A SCN10A

1.11e-032771207GO:0042734
GeneOntologyCellularComponentribonuclease MRP complex

RPP30 RPP38

1.15e-0391202GO:0000172
GeneOntologyCellularComponentdendrite

CACNA1A CACNA1B CTTNBP2 RPS6 DOCK10 DCX LRIT3 OPHN1 TTLL7 RGS14 SYT11 SCN8A PREX1

1.31e-0385812013GO:0030425
GeneOntologyCellularComponentpresynaptic active zone

CACNA1A CACNA1B P2RY2 SYT11 SCN8A

1.33e-031411205GO:0048786
GeneOntologyCellularComponentdendritic tree

CACNA1A CACNA1B CTTNBP2 RPS6 DOCK10 DCX LRIT3 OPHN1 TTLL7 RGS14 SYT11 SCN8A PREX1

1.34e-0386012013GO:0097447
GeneOntologyCellularComponentmultimeric ribonuclease P complex

RPP30 RPP38

1.43e-03101202GO:0030681
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN8A SCN10A UNC80

1.54e-033781208GO:0034702
GeneOntologyCellularComponentsomatodendritic compartment

CACNA1A CACNA1B CACNA1E CTTNBP2 RPS6 DOCK10 UPF3B DCX LRIT3 OPHN1 TTLL7 RGS14 ADRA2C SYT11 SCN8A PREX1

1.76e-03122812016GO:0036477
GeneOntologyCellularComponentribonuclease P complex

RPP30 RPP38

2.84e-03141202GO:0030677
GeneOntologyCellularComponentmitochondrial nucleoid

SLC25A5 DBT DNAJA3

3.14e-03511203GO:0042645
GeneOntologyCellularComponentnucleoid

SLC25A5 DBT DNAJA3

3.14e-03511203GO:0009295
HumanPhenoBroad proximal phalanx of the hallux

FGFR1 FGFR2

4.07e-052332HP:0010086
HumanPhenoCalcaneonavicular fusion

FGFR1 FGFR2

4.07e-052332HP:0008122
HumanPheno3-4 toe cutaneous syndactyly

FGFR1 FGFR2

4.07e-052332HP:6000648
HumanPhenoBroad middle phalanges of the toes

FGFR1 FGFR2

4.07e-052332HP:0010195
HumanPhenoTracheal cartilaginous sleeve

FGFR1 FGFR2

4.07e-052332HP:0005347
MousePhenoabnormal channel response

CACNA1A CACNA1B CACNA1E CACNB3 UNC80

2.40e-0633935MP:0003484
MousePhenoabnormal action potential

CACNA1A GDAP1 SLC6A4 RGS14 SCN8A SCN10A FGFR1

2.89e-05133937MP:0005402
MousePhenopremature facial suture closure

FGFR1 FGFR2

4.38e-052932MP:0030390
DomainDCX

DCX DCLK2 DCLK1

4.85e-0661183SM00537
DomainVDCC_a1su_IQ

CACNA1A CACNA1B CACNA1E

8.45e-0671183IPR014873
Domain-

DCX DCLK2 DCLK1

8.45e-06711833.10.20.230
DomainGPHH

CACNA1A CACNA1B CACNA1E

8.45e-0671183PF16905
DomainDCX

DCX DCLK2 DCLK1

8.45e-0671183PF03607
DomainGPHH_dom

CACNA1A CACNA1B CACNA1E

8.45e-0671183IPR031649
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

8.45e-0671183SM01062
DomainCa_chan_IQ

CACNA1A CACNA1B CACNA1E

8.45e-0671183PF08763
DomainDC

DCX DCLK2 DCLK1

1.35e-0581183PS50309
DomainDoublecortin_dom

DCX DCLK2 DCLK1

1.35e-0581183IPR003533
DomainAden_trnslctor

SLC25A41 SLC25A4 SLC25A5 SLC25A6

2.76e-05281184IPR002113
DomainVDCCAlpha1

CACNA1A CACNA1B CACNA1E

2.86e-05101183IPR002077
DomainChannel_four-helix_dom

CACNA1A CACNA1B CACNA1E SCN8A SCN10A

2.98e-05571185IPR027359
Domain-

CACNA1A CACNA1B CACNA1E SCN8A SCN10A

2.98e-055711851.20.120.350
DomainMit_carrier

SLC25A41 SLC25A4 SLC25A5 SLC25A6

4.75e-05321184IPR002067
DomainMit_uncoupling

SLC25A4 SLC25A5 SLC25A6

5.19e-05121183IPR002030
DomainIon_trans_dom

CACNA1A CACNA1B CACNA1E KCNQ4 SCN8A SCN10A

8.57e-051141186IPR005821
DomainIon_trans

CACNA1A CACNA1B CACNA1E KCNQ4 SCN8A SCN10A

8.57e-051141186PF00520
DomainWTX

AMER3 AMER2

1.18e-0431182PF09422
DomainUncharacterised_FAM123

AMER3 AMER2

1.18e-0431182IPR019003
DomainFGF_rcpt_fam

FGFR1 FGFR2

2.36e-0441182IPR016248
DomainDEP

PREX2 PIKFYVE PREX1

3.47e-04221183PF00610
DomainDEP

PREX2 PIKFYVE PREX1

3.47e-04221183PS50186
DomainDEP

PREX2 PIKFYVE PREX1

3.47e-04221183SM00049
DomainSOLCAR

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.49e-04531184PS50920
Domain-

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.49e-045311841.50.40.10
DomainMitochondrial_sb/sol_carrier

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.49e-04531184IPR018108
DomainMito_carr

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.49e-04531184PF00153
DomainMt_carrier_dom

SLC25A41 SLC25A4 SLC25A5 SLC25A6

3.49e-04531184IPR023395
DomainDEP_dom

PREX2 PIKFYVE PREX1

3.97e-04231183IPR000591
DomainTAS2R

TAS2R45 TAS2R30 TAS2R46

5.75e-04261183PF05296
DomainT2R

TAS2R45 TAS2R30 TAS2R46

5.75e-04261183IPR007960
DomainUSP_CS

USP49 USP24 USP21 USP6

8.07e-04661184IPR018200
DomainUSP_1

USP49 USP24 USP21 USP6

1.01e-03701184PS00972
DomainUCH

USP49 USP24 USP21 USP6

1.06e-03711184PF00443
DomainUSP_2

USP49 USP24 USP21 USP6

1.06e-03711184PS00973
DomainUSP_3

USP49 USP24 USP21 USP6

1.12e-03721184PS50235
DomainUSP_dom

USP49 USP24 USP21 USP6

1.12e-03721184IPR028889
DomainPeptidase_C19_UCH

USP49 USP24 USP21 USP6

1.12e-03721184IPR001394
DomainNa_channel_asu

SCN8A SCN10A

1.72e-03101182IPR001696
DomainNa_trans_assoc

SCN8A SCN10A

1.72e-03101182IPR010526
DomainADR_fam

ADRA2B ADRA2C

1.72e-03101182IPR002233
DomainNa_trans_assoc

SCN8A SCN10A

1.72e-03101182PF06512
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1A CACNA1B CACNA1E SLC25A4 SLC25A5 SLC25A6

7.35e-0923956M47666
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNA1E CACNB3

6.16e-0711954MM14498
PathwayREACTOME_PRESYNAPTIC_DEPOLARIZATION_AND_CALCIUM_CHANNEL_OPENING

CACNA1A CACNA1B CACNA1E CACNB3

6.16e-0711954M26913
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1A CACNA1B CACNA1E CACNB3

2.20e-0525954M47948
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01006

SLC25A4 SLC25A5 SLC25A6

3.44e-0510953M47694
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1A CACNA1B CACNA1E

4.70e-0511953M47958
PathwayREACTOME_TRANSPORT_OF_NUCLEOSIDES_AND_FREE_PURINE_AND_PYRIMIDINE_BASES_ACROSS_THE_PLASMA_MEMBRANE

SLC25A4 SLC25A5 SLC25A6

6.24e-0512953M27728
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN1_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

8.07e-0513953M47696
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_SIGMAR1_TO_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

8.07e-0513953M47751
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SNCA_TO_VGCC_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

8.07e-0513953M47703
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004

SLC25A4 SLC25A5 SLC25A6

1.02e-0414953M47692
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

1.27e-0415953M47691
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PSEN_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

1.56e-0416953M47695
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABBERANT_ATXN2_3_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

2.25e-0418953M47659
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

2.25e-0418953M47761
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

SLC25A4 SLC25A5 SLC25A6

2.66e-0419953M47677
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

2.66e-0419953M47760
PathwayKEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.11e-0420953M47688
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

3.61e-0421953M47689
PathwayWP_SYNAPTIC_VESICLE_PATHWAY

CACNA1A CACNA1B SLC25A4 SLC6A4

3.80e-0451954M39457
PathwayKEGG_TASTE_TRANSDUCTION

CACNA1A CACNA1B TAS2R45 TAS2R46

4.09e-0452954M5785
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

4.16e-0422953M47690
PathwayKEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

4.16e-0422953M47675
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY

SLC25A4 SLC25A5 SLC25A6

4.76e-0423953M47676
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A CACNA1E CACNB3 ADRA2C

7.53e-0461954MM15071
PathwayREACTOME_SENSORY_PERCEPTION_OF_TASTE

TAS2R45 TAS2R30 TAS2R46

1.16e-0331953MM15691
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1A CACNA1B CACNA1E SLC25A4 SLC25A5 SLC25A6

1.28e-03178956M2890
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A CACNA1E CACNB3 ADRA2C

1.40e-0372954MM14631
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

FGFR1 FGFR2

1.57e-039952M47397
PathwayREACTOME_ADRENOCEPTORS

ADRA2B ADRA2C

1.57e-039952M27302
PathwayREACTOME_ADRENOCEPTORS

ADRA2B ADRA2C

1.57e-039952MM15009
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A CACNA1E CACNB3 ADRA2C

1.89e-0378954M1921
PathwayREACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS

TAS2R45 TAS2R30 TAS2R46

1.95e-0337953MM15067
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

SLC25A4 SLC25A5 SLC25A6

1.95e-0337953M1029
PathwayBIOCARTA_ETC_PATHWAY

SLC25A4 SLC25A6

1.95e-0310952M15371
PathwayWP_CELL_LINEAGE_MAP_FOR_NEURONAL_DIFFERENTIATION

PECAM1 DCX SLC6A4 ADRA2B ADRA2C

1.97e-03132955M48110
Pubmed

Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.

CACNA1A CACNA1B CACNA1E CACNB3

7.19e-10512248825650
Pubmed

The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.

SLC25A4 SLC25A5 SLC25A6

4.21e-083122312450408
Pubmed

The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

4.21e-083122338996073
Pubmed

DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase.

SLC25A4 SLC25A5 SLC25A6

4.21e-08312232541251
Pubmed

Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

SLC25A4 SLC25A5 SLC25A6

4.21e-08312232829183
Pubmed

Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.

CACNA1A CACNA1B CACNA1E

4.21e-083122324523520
Pubmed

Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice.

DCX DCLK2 DCLK1

4.21e-083122318075264
Pubmed

Cerebellar granule cell signaling is indispensable for normal motor performance.

CACNA1A CACNA1B CACNA1E

1.68e-074122337141091
Pubmed

The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis.

DCX DCLK2 DCLK1

1.68e-074122333199366
Pubmed

Synapse and Active Zone Assembly in the Absence of Presynaptic Ca2+ Channels and Ca2+ Entry.

CACNA1A CACNA1B CACNA1E

1.68e-074122332616470
Pubmed

Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.

SLC25A4 SLC25A5 SLC25A6

1.68e-074122333396658
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1A CACNA1B CACNA1E CACNB3

1.91e-0715122420188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1A CACNA1B CACNA1E CACNB3

1.91e-0715122424453333
Pubmed

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.

CACNA1A CACNA1B CACNA1E

4.19e-075122311296258
Pubmed

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit.

CACNA1A CACNA1B CACNB3

4.19e-075122316787652
Pubmed

Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.

CACNA1A CACNA1B CACNA1E

4.19e-075122315451373
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN8A SCN10A

6.39e-07139122716985003
Pubmed

An action potential initiation mechanism in distal axons for the control of dopamine release.

CACNA1A CACNA1B CACNA1E

8.36e-076122335324301
Pubmed

The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.

SLC25A4 SLC25A5 SLC25A6

8.36e-076122310620603
Pubmed

beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.

CACNA1A CACNA1B CACNB3

8.36e-076122310328888
Pubmed

Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis.

CACNA1A CACNA1B CACNA1E

8.36e-076122312827191
Pubmed

Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.

CACNA1A CACNA1B CACNA1E

8.36e-07612239238069
Pubmed

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system.

SLC25A4 SLC25A5 SLC25A6

1.46e-067122321370995
Pubmed

Rebuilding essential active zone functions within a synapse.

CACNA1A CACNA1B CACNA1E

1.46e-067122335176221
Pubmed

Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

CACNA1B CACNA1E RPS6 SORBS1 RPS25 SH2D5 AMER2 DCLK1

1.69e-06231122816452087
Pubmed

Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.

PECAM1 FGFR1 FGFR2

2.33e-068122318297725
Pubmed

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

SLC25A4 SLC25A5 SLC25A6

2.33e-068122327641616
Pubmed

Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula.

PECAM1 FGFR1 FGFR2

2.33e-068122328389228
Pubmed

FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network.

PECAM1 FGFR1 FGFR2

2.33e-068122317881491
Pubmed

Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A.

SLC6A4 ADRA2B ADRA2C SCN8A

2.76e-0628122419352218
Pubmed

Mechanosensitive mTORC1 signaling maintains lymphatic valves.

RPS6 PECAM1 LYVE1

3.48e-069122337036444
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1A CACNA1B CACNA1E

3.48e-069122316382099
Pubmed

Knockout of the epilepsy gene Depdc5 in mice causes severe embryonic dysmorphology with hyperactivity of mTORC1 signalling.

RPS6 PECAM1 LYVE1

3.48e-069122328974734
Pubmed

Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination.

PECAM1 FGFR1 FGFR2

3.48e-069122315229180
Pubmed

Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration.

DCX DCLK2 DCLK1

3.48e-069122316387639
Pubmed

The doublecortin gene family and disorders of neuronal structure.

DCX DCLK2 DCLK1

4.96e-0610122320236041
Pubmed

The evolving doublecortin (DCX) superfamily.

DCX DCLK2 DCLK1

4.96e-0610122316869982
Pubmed

Ion channel expression in the developing enteric nervous system.

CACNA1A CACNA1B CACNB3 KCNQ4

8.70e-0637122425798587
Pubmed

The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.

TAS2R45 TAS2R30 TAS2R46

9.05e-0612122312379855
Pubmed

Mitochondrial membrane permeabilization by HIV-1 Vpr.

SLC25A4 SLC25A5 SLC25A6

9.05e-0612122316120388
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1A CACNA1B CACNA1E CACNB3

9.70e-0638122430786075
Pubmed

FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains.

PECAM1 FGFR1 FGFR2

1.17e-0513122316540513
Pubmed

Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice.

TAS2R45 TAS2R30 TAS2R46

1.17e-0513122315938754
Pubmed

Endothelial cell FGF signaling is required for injury response but not for vascular homeostasis.

PECAM1 FGFR1 FGFR2

1.17e-0513122325139991
Pubmed

FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium.

PECAM1 FGFR1 FGFR2

1.17e-0513122321750042
Pubmed

Growth hormone promotes lymphangiogenesis.

PECAM1 LYVE1

1.22e-052122218583315
Pubmed

Structural and functional diversity in the FGF receptor multigene family.

FGFR1 FGFR2

1.22e-05212228417497
Pubmed

Doublecortin and doublecortin-like are expressed in overlapping and non-overlapping neuronal cell population: implications for neurogenesis.

DCX DCLK1

1.22e-052122222605579
Pubmed

Facial suture synostosis of newborn Fgfr1(P250R/+) and Fgfr2(S252W/+) mouse models of Pfeiffer and Apert syndromes.

FGFR1 FGFR2

1.22e-052122221538817
Pubmed

Blocking the R-type (Cav2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance.

CACNA1B CACNA1E

1.22e-052122215610184
Pubmed

Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

CACNA1A CACNA1B

1.22e-052122223426690
Pubmed

Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels.

CACNA1B CACNB3

1.22e-052122212161429
Pubmed

Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations.

FGFR1 FGFR2

1.22e-052122215863034
Pubmed

Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.

RPP30 RPP38

1.22e-05212229037013
Pubmed

Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution.

FGFR1 FGFR2

1.22e-052122228187268
Pubmed

The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain.

FGFR1 FGFR2

1.22e-05212221652059
Pubmed

Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis.

FGFR1 FGFR2

1.22e-052122220308431
Pubmed

Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.

FGFR1 FGFR2

1.22e-052122217284663
Pubmed

Spatial distribution and functional relevance of FGFR1 and FGFR2 expression for glioblastoma tumor invasion.

FGFR1 FGFR2

1.22e-052122237579831
Pubmed

Cardiovascular regulation in mice lacking alpha2-adrenergic receptor subtypes b and c.

ADRA2B ADRA2C

1.22e-05212228670422
Pubmed

Molecular and Functional Relevance of NaV1.8-Induced Atrial Arrhythmogenic Triggers in a Human SCN10A Knock-Out Stem Cell Model.

SLC6A4 SCN10A

1.22e-052122237373335
Pubmed

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.

FGFR1 FGFR2

1.22e-052122230914635
Pubmed

Developmental expression of two murine fibroblast growth factor receptors, flg and bek.

FGFR1 FGFR2

1.22e-05212221667382
Pubmed

Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.

PREX2 PREX1

1.22e-052122220694145
Pubmed

Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures.

DCX DCLK2

1.22e-052122219342486
Pubmed

Changes in the expression of the human adenine nucleotide translocase isoforms condition cellular metabolic/proliferative status.

SLC25A5 SLC25A6

1.22e-052122226842067
Pubmed

Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso.

HS3ST3B1 HS3ST3A1

1.22e-052122222475533
Pubmed

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore.

SLC25A4 SLC25A5

1.22e-052122214749836
Pubmed

Synthetic Aβ oligomers (Aβ(1-42) globulomer) modulate presynaptic calcium currents: prevention of Aβ-induced synaptic deficits by calcium channel blockers.

CACNA1A CACNA1B

1.22e-052122223376566
Pubmed

KIAA0369, doublecortin-like kinase, is expressed during brain development.

DCX DCLK1

1.22e-052122210533048
Pubmed

Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis.

FGFR1 FGFR2

1.22e-052122225171497
Pubmed

Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis.

FGFR1 FGFR2

1.22e-052122225926357
Pubmed

Immunolocalization of fibroblast growth factor receptors 1 and 2 in mouse palate development.

FGFR1 FGFR2

1.22e-052122211391199
Pubmed

The DCX-domain tandems of doublecortin and doublecortin-like kinase.

DCX DCLK1

1.22e-052122212692530
Pubmed

Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo.

FGFR1 FGFR2

1.22e-052122236382369
Pubmed

The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.

FGFR1 FGFR2

1.22e-052122216188231
Pubmed

CaV 2.1 α1  subunit motifs that control presynaptic CaV 2.1 subtype abundance are distinct from CaV 2.1 preference.

CACNA1A CACNA1B

1.22e-052122238155373
Pubmed

Conserved use of a non-canonical 5' splice site (/GA) in alternative splicing by fibroblast growth factor receptors 1, 2 and 3.

FGFR1 FGFR2

1.22e-05212229499422
Pubmed

Doublecortin (Dcx) family proteins regulate filamentous actin structure in developing neurons.

DCX DCLK1

1.22e-052122223303949
Pubmed

Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells.

FGFR1 FGFR2

1.22e-052122221527526
Pubmed

Epistasis between 5-HTTLPR and ADRA2B polymorphisms influences attentional bias for emotional information in healthy volunteers.

SLC6A4 ADRA2B

1.22e-052122221854681
Pubmed

Characterization of the regulatory regions of murine alpha 2C2 adrenoceptor subtype gene.

ADRA2B ADRA2C

1.22e-05212228762185
Pubmed

The doublecortin and doublecortin-like kinase 1 genes cooperate in murine hippocampal development.

DCX DCLK1

1.22e-052122216766710
Pubmed

FGFR1 and FGFR2 mutations in Pfeiffer syndrome.

FGFR1 FGFR2

1.22e-052122223348274
Pubmed

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.

PREX2 PREX1

1.22e-052122218334636
Pubmed

Loss of Fgfr1 and Fgfr2 in Scleraxis-lineage cells leads to enlarged bone eminences and attachment cell death.

FGFR1 FGFR2

1.22e-052122237212424
Pubmed

Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin.

DCX DCLK1

1.22e-05212229747029
Pubmed

A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions.

SLC25A4 SLC25A6

1.22e-052122212112115
Pubmed

Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse.

FGFR1 FGFR2

1.22e-05212221315677
Pubmed

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.

RTTN STIL

1.22e-052122228811500
Pubmed

FGFR1 down-regulation in differentiating human brain and spinal cord neurospheres.

FGFR1 FGFR2

1.22e-052122215618886
Pubmed

Leucine-rich repeat, immunoglobulin-like and transmembrane domain 3 (LRIT3) is a modulator of FGFR1.

LRIT3 FGFR1

1.22e-052122222673519
Pubmed

Role of adenine nucleotide translocator 1 in mtDNA maintenance.

SLC25A4 SLC25A6

1.22e-052122210926541
Pubmed

Decreases in pheromonal responses at the accessory olfactory bulb of mice with a deficiency of the alpha1B or beta3 subunits of voltage-dependent Ca2+-channels.

CACNA1B CACNB3

1.22e-052122216508141
Pubmed

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation.

DCLK2 DCLK1

1.22e-052122223385585
Pubmed

Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation.

FGFR1 FGFR2

1.22e-052122214559809
Pubmed

P-Rex1 and P-Rex2 RacGEFs and cancer.

PREX2 PREX1

1.22e-052122228710285
Pubmed

Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice.

CACNA1A CACNA1E

1.22e-052122216381801
Pubmed

Involvement of fibroblast growth factor receptor genes in benign prostate hyperplasia in a Korean population.

FGFR1 FGFR2

1.22e-052122224385678
Pubmed

FGFR1 and FGFR2 in fibrolamellar carcinoma.

FGFR1 FGFR2

1.22e-052122226259677
InteractionSCN11A interactions

CACNA1A CACNA1B SCN8A SCN10A

1.31e-06151154int:SCN11A
InteractionCACNA1D interactions

CACNA1A CACNA1B SCN10A FGFR2

9.79e-06241154int:CACNA1D
GeneFamilyCalcium voltage-gated channel subunits

CACNA1A CACNA1B CACNA1E CACNB3

6.29e-0626854253
GeneFamilyDoublecortin superfamily

DCX DCLK2 DCLK1

1.18e-05108531369
GeneFamilyUbiquitin specific peptidases

USP49 USP24 USP21 USP6

1.39e-0456854366
GeneFamilySolute carriers

SLC25A41 SLC25A4 SLC25A5 SLC25A6 SLC46A1 SLC34A3 SLC5A5 SLC6A4

5.37e-04395858752
GeneFamilySodium voltage-gated channel alpha subunits

SCN8A SCN10A

7.70e-0498521203
GeneFamilyAdrenoceptors

ADRA2B ADRA2C

7.70e-049852169
GeneFamilyTaste 2 receptors

TAS2R45 TAS2R30 TAS2R46

8.11e-04398531162
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRIT3 MFAP3 FGFR1 FGFR2 ADGRA3

9.73e-04161855593
GeneFamilyX-linked mental retardation|Angiotensin receptors

UPF3B BRWD3 OPHN1

1.98e-0353853103
CoexpressionHE_LIM_SUN_FETAL_LUNG_C1_INTERM_NEUROENDOCRINE_CELL

CACNA1A CTTNBP2 INHBA GDAP1 RAP1GAP2 RFX6 DCX TTLL7 SYT11

4.15e-062681209M45696
CoexpressionZHONG_PFC_C3_MICROGLIA

CACNA1A CACNA1B CACNA1E CACNB3 RAP1GAP2 DPYSL4 DCX AMER2 MAST4 DCLK2 DCLK1

1.56e-0548812011M39104
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MIS18BP1 RTTN RAP1GAP2 IRF5 STIL WDFY4 HS3ST3B1 CDCA5

2.01e-08168121852fd65024af8683db11d931f7563cbe8eb815d1c
ToppCellTCGA-Adrenal-Primary_Tumor-Pheochromocytoma-Pheochromocytoma-1|TCGA-Adrenal / Sample_Type by Project: Shred V9

CACNA1B GDAP1 RAP1GAP2 SORBS1 TTLL7 SYT11 DCLK1 UNC80

3.29e-081791218431e1b29015ec817f778499106d24b19cfc825ae
ToppCellEndothelial-Endothelial-A|Endothelial / shred on cell class and cell subclass (v4)

SLC25A4 SLC25A5 RPS6 MCM3 SORBS1 RPS25 LYVE1

4.43e-08122121765849d1296934d5765afd006cbb6739383b9f49f
ToppCell18-Distal-Mesenchymal-Cartilage|Distal / Age, Tissue, Lineage and Cell class

COL11A2 INHBA RPS6 RPS25 FZD9 ADRA2C FGFR2 ADGRA3

5.90e-08193121852f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 OPHN1 FZD9 PLPP4 FGFR1 UNC80 WNK3 CDH18

7.47e-08199121819a97e27a4758e794ce7246d295e112b47931a48
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-2|TCGA-Lung / Sample_Type by Project: Shred V9

USP49 MCM3 STIL TTLL7 RIC8B WNK3 CDH18

2.60e-0715812179dea15b28f64206bac0e785df6f36a2cc9010ac7
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1B CACNA1E GDAP1 RFX6 UNC80 CDH18

3.79e-071671217c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1B DCX TTLL7 SYT11 PLPP4 DCLK1 UNC80

6.28e-071801217368ff7fcfd21ad248f96a83a8b191040ba7d8670
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-5|TCGA-Breast / Sample_Type by Project: Shred V9

SLC25A5 INHBA DPP3 P4HA1 PLPP4 CDCA5 CBX2

6.76e-0718212179e48d5b634603bc7a8d29290202a311457678328
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC-OPC_L1-6_MYT1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PREX2 OPHN1 TXNIP ADAMTS17 PLPP4 FGFR1

7.54e-071851217efc5d564f8793c751ba640aef60f761e4b081d3f
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-OPC|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DOCK10 PREX2 OPHN1 TXNIP ADAMTS17 PLPP4 FGFR1

7.54e-071851217fba2dc46cd98ab9c78e788959c2121aa10d148b2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MIS18BP1 DOCK10 STIL WDFY4 DDIAS CDCA5 PREX1

8.11e-07187121773931a5ea73799095daff100b5f18853c57c74dc
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAM234A PECAM1 RAP1GAP2 AKR1A1 BRWD3 LYVE1 OSBPL11

9.02e-07190121763018acb7ad80415e861643162abdc2e55968ee4
ToppCell15-Airway-Mesenchymal-Cartilage|Airway / Age, Tissue, Lineage and Cell class

COL11A2 RPS6 RPS25 OPHN1 FZD9 FGFR2 ADGRA3

1.07e-061951217414f60bc0f0d0ecb5137bcd617fae91f0c15038a
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

TMPPE CACNA1A CTTNBP2 INHBA SCN8A UNC80 CBX2

1.15e-061971217ff4df77117165b6b25315e29b0722cc136eba607
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alv_dividing|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MIS18BP1 INHBA SLC46A1 STIL WDFY4 SLFN11 CDCA5

1.15e-061971217d669d90c3f9e98b41bcbc49dbdc5698e0b42597c
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PECAM1 MCM3 STIL DDIAS LYVE1 ADGRA3

5.62e-0616312163efbbdc9cb2613bb76d8c2f07cd4ec1a2c51a622
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1B RFX6 SCN8A UNC80 CDH18

5.82e-061641216be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CTTNBP2 SORBS1 TTLL7 MAST4 SEC14L6 WNK3

6.24e-061661216c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-tracheal_fibroblast|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL11A2 INHBA RCN1 DPYSL4 FZD9 UNC80

6.91e-06169121658e22f9119240664515fe91ca53812611a8f17d6
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A CACNA1B CACNA1E RFX6 UNC80 CDH18

6.91e-061691216b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellwk_15-18-Epithelial-Proximal_epithelial-Pulmonary_NE_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CACNA1A RAP1GAP2 AMER3 SLC34A3 DCX TTLL7

7.15e-06170121698d13dbd76a826e47d55553f9d11f71c043b573e
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

CACNA1A CACNA1B DPYSL4 DCLK1 UNC80 CDH18

8.43e-0617512164db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

CACNA1A CACNA1B DPYSL4 DCLK1 UNC80 CDH18

8.43e-0617512168d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA1A CACNA1B RFX6 SCN8A UNC80 CDH18

1.05e-05182121657bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-D|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC25A6 GDAP1 AMER3 DCX OPHN1 SLC5A5

1.09e-0518312160e468daed40c28dca64a9bc2867b46e4ea9d1a06
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Endothelial-endocardial_endothelial_cells|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRC9 FZD9 PRDM11 FGFR2 HS3ST3B1 ADGRA3

1.09e-051831216b0b5a41f1a40f9c946d0dc8b67eaccdd9f9b73a5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A5 SLC25A6 RPS6 DOCK10 RPS25 TXNIP

1.12e-051841216282118f8221fa383ffb81dfb5798a0b7f065f911
ToppCellwk_08-11-Epithelial-PNS-PCP4+_neuron|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNA1B DCX SCN8A PLPP4 DCLK2 DCLK1

1.12e-051841216eac2a9089913f33a961ba11519b53645790f2056
ToppCellPBMC-Mild-cDC_9|Mild / Compartment, Disease Groups and Clusters

CACNA1B TTLL7 LYVE1 MFAP3 SCN8A CDCA5

1.12e-0518412162e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC25A5 SLC25A6 DOCK10 TXNIP PLPP4 UNC80

1.16e-0518512169438097e94219c1db922b8507e3a29106d32a923
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A CACNA1B RFX6 SCN8A UNC80 CDH18

1.19e-051861216b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A CACNA1B RFX6 SCN8A UNC80 CDH18

1.27e-051881216c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA1A DCX FZD9 SYT11 UNC80 CDH18

1.27e-051881216e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A AMER3 DCX FZD9 UNC80 CDH18

1.35e-05190121640d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A AMER3 DCX FZD9 UNC80 CDH18

1.35e-051901216f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA1A AMER3 DCX FZD9 UNC80 CDH18

1.35e-051901216a9a705455019e28d655636de73b07540798f82e6
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNA1B RAP1GAP2 RFX6 AMER3 TTLL7 UNC80

1.35e-051901216b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCellLPS-antiTNF-Endothelial-Endothelial-Artery|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CTTNBP2 PECAM1 ITPRID2 PREX2 CERS5 DCLK1

1.39e-0519112164b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCellP07-Endothelial-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MIS18BP1 PECAM1 MCM3 STIL LYVE1 CDCA5

1.47e-0519312161e95ef29357969ee385b4717c0b5a497390ac260
ToppCell5'-Adult-SmallIntestine-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NUGGC DOCK10 TXNIP SEC14L6 ADAMTS17 PREX1

1.47e-051931216544de0988510cc57744710d7cafe07aa27a0b99d
ToppCellP07-Endothelial-proliferative_endothelial_cell-proliferative_endothelial_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

MIS18BP1 PECAM1 MCM3 STIL LYVE1 CDCA5

1.47e-0519312160f21fb8b35f89f4c1c8109d1a4d3d08a452f9edd
ToppCell11.5-Distal-Epithelial-Neuroendocrine|Distal / Age, Tissue, Lineage and Cell class

INHBA RAP1GAP2 RFX6 AMER3 DCX TTLL7

1.56e-051951216eda6ebe52c48bd6a9044886e75f584f46c2556e7
ToppCellCOPD-Endothelial-VE_Capillary_B|Endothelial / Disease state, Lineage and Cell class

PECAM1 SORBS1 OPHN1 SLC6A4 MAST4 PREX1

1.65e-05197121630dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCellBAL-Severe-Myeloid-TRAM-TRAM2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MIS18BP1 INHBA PECAM1 TXNIP DDIAS SLFN11

1.65e-051971216d8ef5cb88dd66e112cb94217b9ad5cd70164f1d0
ToppCellBAL-Severe-Myeloid-TRAM-TRAM2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MIS18BP1 INHBA PECAM1 TXNIP DDIAS SLFN11

1.65e-05197121633f2fe101ae5744eea3915add37e60aa398bb97f
ToppCellBAL-Severe-Myeloid-TRAM-TRAM2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MIS18BP1 INHBA PECAM1 TXNIP DDIAS SLFN11

1.65e-0519712165e9a3932ae5147a3d73dc70f1545926a692930ed
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1B DCX AMER2 SYT11 PLPP4 DCLK1

1.65e-051971216f7eaac1c321710a55e09ffb047a7db2baf7b7e28
ToppCellSevere_COVID-19-Myeloid-TRAM2|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

MIS18BP1 INHBA PECAM1 TXNIP DDIAS SLFN11

1.65e-0519712168a126cfe1529f3d75a806aa492743314a8a43ef9
ToppCellBAL-Severe-Myeloid-TRAM-TRAM2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MIS18BP1 INHBA PECAM1 TXNIP DDIAS SLFN11

1.65e-0519712169262785807faeb32417fad7ef202405053e453e2
ToppCellTransverse-T_cell-cycling_gd_T|Transverse / Region, Cell class and subclass

USP49 DPYSL4 SYT11 ADAMTS17 CDCA5 CBX2

1.70e-0519812165131b0b7d6c4dd8872cef9f2e233f59f751b4690
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A CACNA1B SCN8A DCLK1 UNC80 CDH18

1.70e-051981216c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A RFX6 SLC34A3 SCN8A UNC80 CDH18

1.70e-0519812168f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A CACNA1B SCN8A DCLK1 UNC80 CDH18

1.70e-0519812166d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1B SORBS1 SCN8A DCLK1 UNC80 CDH18

1.70e-0519812168ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A CACNA1B SCN8A DCLK1 UNC80 CDH18

1.70e-0519812164ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellTransverse-(1)_T_cell-(18)_cycling_gd_T|Transverse / shred on region, Cell_type, and subtype

USP49 DPYSL4 SYT11 ADAMTS17 CDCA5 CBX2

1.70e-051981216396dddf7ebad41c3a91329b6a280623c0dfdcd2f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A RFX6 SLC34A3 SCN8A UNC80 CDH18

1.70e-051981216e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 OPHN1 FZD9 PLPP4 FGFR1 UNC80

1.75e-051991216333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

RPS6 RCN1 RPS25 TXNIP P4HA1 FGFR1

1.75e-0519912163c9bd4d4b166788f807eaaf4f74735949031c295
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

USP24 OPHN1 FZD9 PLPP4 FGFR1 UNC80

1.75e-051991216e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A2 SORBS1 TXNIP HS3ST3B1 HS3ST3A1 ADGRA3

1.80e-052001216b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MIS18BP1 RCN1 MCM3 FGFR1 FGFR2 CDCA5

1.80e-052001216474e6ab48f199315f3cca86b81fdf54e0461b7b8
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A2 SORBS1 TXNIP HS3ST3B1 HS3ST3A1 ADGRA3

1.80e-052001216f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNA1A CACNA1B SCN8A DCLK1 UNC80 CDH18

1.80e-05200121648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellBronchial-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A2 TIMP4 FGFR1 HS3ST3B1 HS3ST3A1 ADGRA3

1.80e-052001216b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PECAM1 SORBS1 PREX2 SLC6A4 AMER2 PREX1

1.80e-052001216105c67e4f5eff036013d655c8e8ac577d32dae2e
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW10-Stem_cells-Stem_cells|GW10 / Sample Type, Dataset, Time_group, and Cell type.

MIS18BP1 RCN1 MCM3 FGFR1 FGFR2 CDCA5

1.80e-05200121601a29651e9bb64ef7666c6a61ec396eeb88b2816
ToppCellBronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A2 TIMP4 FGFR1 HS3ST3B1 HS3ST3A1 ADGRA3

1.80e-0520012167c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCellNS-critical-d_0-4-Lymphoid-NKT|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

NUGGC RPS6 MCM3 RPS25 SLC6A4

6.36e-05154121508ffa4b6f4a1c3de037acf9d30bd14c195738ad9
ToppCellfacs-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 IRF5 ITPRID2 RGS14 PREX1

6.76e-0515612153f0b9e35d4da85c90759b930052e5b9c3cde9b15
ToppCellfacs-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 IRF5 ITPRID2 RGS14 PREX1

6.76e-05156121569e6e8810d1738a66c9821910f41498931cf30cc
ToppCellfacs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1B PECAM1 TMPRSS11F TIMP4 SCN10A

7.18e-05158121578b48b110b777bcc4c07cd23388bee911c0231d6
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A INHBA RFX6 UNC80 CDH18

7.39e-0515912157747cef94c55144fddcd024a7495318357f1351b
ToppCellLPS-antiTNF-Endothelial-Endothelial-FOXM1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MIS18BP1 MCM3 STIL DDIAS CDCA5

8.31e-0516312155285318c52aa31c9b22dc2ffff078e32e408604d
ToppCelldroplet-Skin-nan-18m-Epithelial-stem_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP49 MIS18BP1 STIL SCN8A CDCA5

8.81e-05165121596f0d8bc9b13e23f757e6bb98cd7dc061a8a9564
ToppCelldroplet-Heart-4Chambers-18m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PECAM1 NXPE3 PRDM11 TIMP4

8.91e-05861214d20ec61a572b11641647358a546334b217c694f3
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A41 CTTNBP2 DPYSL4 LRRC9 FZD9

9.32e-051671215cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCell367C-Lymphocytic-ILC-ILC-1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NUGGC COL11A2 THAP9 TTLL7 LYVE1

9.59e-05168121580233a13135fd159f5764336a1fe67fba237776b
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK10 IRF5 WDFY4 AMER2 SCN8A

9.59e-05168121584977db9d71e59208727885320cc18d80d064380
ToppCellBronchial_Biopsy-Immune-Mast_cells|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X

CTTNBP2 GDAP1 SYT11 VPS13B WNK3

9.59e-05168121545ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCelldroplet-Liver-Npc-18m-Myeloid-myeloid_leukocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 RAP1GAP2 IRF5 WDFY4 UNC80

9.59e-051681215ce5e92a1df3acfa5cd8d5a134e4af231dc592a13
ToppCelldroplet-Liver-Npc-18m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 RAP1GAP2 IRF5 WDFY4 UNC80

9.59e-05168121522c89d4eb44573f6301069ec7ca7cbd0dd958403
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A RFX6 KCNQ4 UNC80 WNK3

9.86e-05169121596a2aec9acf8a6f966973c035e5ade456cf47772
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A41 CTTNBP2 DPYSL4 LRRC9 FZD9

9.86e-05169121530141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-mLTo|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DDIAS OTOGL ADAMTS17 HS3ST3A1 DCLK1

9.86e-051691215559e98216720e4babf0b0941100f1b485c35b11b
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC3-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SLC25A5 SLC25A6 RPS6 RAP1GAP2 WDFY4

1.01e-0417012158276061841665e0952b3661133551ca529131dac
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SORBS1 SLC6A4 KCNQ4 DCLK2 WNK3

1.01e-041701215b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MIS18BP1 IRF5 STIL RGS14 CDCA5

1.04e-0417112156e7ade1d14a3ec4c566476aac3eb509bd2661e39
ToppCellwk_08-11-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

COL11A2 FZD9 FGFR2 TAS2R46 HS3ST3A1

1.07e-041721215415d57aa6278b8c12e7a2cf9c3fa5283389fb9b0
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

USP49 MIS18BP1 MCM3 STIL DDIAS

1.07e-0417212152b6cd84c946b1e800caba452ae70145ea285fec1
ToppCellE15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PECAM1 ITPRID2 PREX2 MAST4 SYT11

1.10e-041731215b0ff9808e38cb64a734ced498cd0546728746cd5
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIS18BP1 DCX DDIAS KCNQ4 CDCA5

1.10e-041731215f38bf7584e08d15a6e2c116b7c3551ba475a5e14
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A CACNA1E RAP1GAP2 RFX6 SLC6A4

1.13e-0417412153503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell(6)_Endothelial_cells-(6)_Endothelial-E|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

SORBS1 SLC6A4 TXNIP LYVE1 PREX1

1.13e-0417412154a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PECAM1 MCM3 STIL LYVE1 CDCA5

1.13e-04174121566555c610251ea04f968c258e312d720c18e7cde
ToppCellmoderate-Myeloid-Mast_cell|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

CTTNBP2 TTLL7 MAST4 SEC14L6 WNK3

1.16e-041751215bbd2971bc6d69e507f90a637834d0936c205c590
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RPP30 MCM3 WDFY4 NXPE3 CDCA5

1.16e-041751215f7d191cde68de8f3457fa62b1df53b6d0dbe5001
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CTTNBP2 DOCK10 LRRC9 PLPP4 UNC80

1.16e-04175121598947a226b5a2ac7091ff9d34243ea7736add973
ToppCellfacs-Diaphragm-Limb_Muscle-18m-Endothelial-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PECAM1 SH2D5 BRWD3 TIMP4 DCLK2

1.19e-041761215a3f27b5d7edf2d396c085efbe35305cfa0afa565
DrugClodronate

SLC25A4 SLC25A5 SLC25A6

1.43e-0731203DB00720
Drugdehydroabietylamine

SLC25A4 SLC25A5 SLC25A6

5.69e-0741203ctd:C000600819
DrugAC 110

CACNA1A CACNA1B CACNA1E

5.69e-0741203CID000022860
DrugVerapamil

CACNA1A CACNA1B CACNB3 SLC6A4

1.27e-06161204DB00661
DrugN6-Me-dAdo

CACNA1A CACNA1B CACNA1E P2RY2

2.68e-06191204CID000168948
Drug3,4-dihydroquinazoline

CACNA1A CACNA1B CACNA1E

2.82e-0661203CID000583065
Drugalpha-sialylcholesterol

CACNA1A CACNA1B CACNA1E

2.82e-0661203CID000133976
DrugAPMPA

CACNA1A CACNA1B CACNA1E

4.92e-0671203CID000512300
Drugclosantel

SLC25A4 SLC25A5 SLC25A6

4.92e-0671203ctd:C023342
DrugMethamphetamine

SLC6A4 ADRA2B ADRA2C

1.67e-05101203DB01577
DrugAC1L4X2K

SLC25A4 SLC25A5 SLC25A6

1.67e-05101203CID000193824
DrugAC1L1D9R

CACNA1A CACNA1B CACNA1E SLC25A4 SLC25A5 SLC25A6

1.78e-051031206CID000002254
Drugleys

CACNA1A CACNA1B CACNA1E

2.28e-05111203CID000484683
DrugCNS 1145

CACNA1A CACNA1B CACNA1E CACNB3

2.67e-05331204CID000190902
DrugIHC-64

CACNA1A CACNA1B CACNA1E CACNB3

2.67e-05331204CID000162753
Drugaristolactam AII

CACNA1B CACNA1E

2.75e-0521202CID000148657
Drugalkosin

CACNA1B CACNA1E

2.75e-0521202CID005488638
Drugnorcepharadione B

CACNA1B CACNA1E

2.75e-0521202CID000189168
Drugpiperolactam A

CACNA1B CACNA1E

2.75e-0521202CID003081016
DrugSU4984

FGFR1 FGFR2

2.75e-0521202DB02058
Drugfluspirilene

CACNA1A CACNA1B CACNA1E ADRA2B

3.01e-05341204CID000003396
DrugEphedra

SLC6A4 ADRA2B ADRA2C

3.03e-05121203DB01363
DrugAC1L2VU3

CACNA1A CACNA1B CACNA1E

3.03e-05121203CID000129572
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

DPYSL4 SORBS1 NXPE3 TXNIP RGS14 SYT11 CDH18

3.89e-0517412076085_UP
Drugbepridil

CACNA1A CACNA1B CACNA1E CACNB3 KCNQ4 SCN10A

5.56e-051261206CID000002351
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

DPYSL4 SORBS1 TTLL7 TXNIP MFAP3 SYT11 CDH18

5.73e-0518512075935_UP
Drugnisoldipine

CACNA1A CACNA1B CACNA1E CACNB3 SLC5A5

5.81e-05781205CID000004499
Drugbutamben

CACNA1A CACNA1B CACNA1E

6.20e-05151203CID000002482
Drugpentasulfane

CACNA1A CACNA1B CACNA1E

7.61e-05161203CID000448216
Drugoleoylcarnitine

SLC25A4 SLC25A5 SLC25A6

7.61e-05161203CID006441392
DrugClonidine

ADRA2B ADRA2C

8.24e-0531202DB00575
DrugBrimonidine

ADRA2B ADRA2C

8.24e-0531202DB00484
Drugcarboxyatractyloside

SLC25A4 SLC25A5

8.24e-0531202ctd:C003853
DrugTizanidine

ADRA2B ADRA2C

8.24e-0531202DB00697
Drugestrone benzoate

FGFR1 FGFR2

8.24e-0531202ctd:C024552
DrugGly-His-Lys acetate salt; Down 200; 1uM; PC3; HT_HG-U133A

INHBA OR1D2 SLC5A5 MFAP3 MAST4 SYT11 FGFR1

8.51e-0519712076570_DN
Drugbeta-hydroxypalmitoyl-CoA

SLC25A4 SLC25A5 SLC25A6

9.20e-05171203CID000440600
Drugpranidipine

CACNA1A CACNA1B CACNA1E

1.30e-04191203CID006436048
DrugDoxepin

SLC6A4 ADRA2B ADRA2C

1.52e-04201203DB01142
Drugagaric acid

SLC25A4 SLC25A5 SLC25A6

1.52e-04201203CID000012629
Drugisotetrandrine

CACNA1A CACNA1B CACNA1E CACNB3 LYVE1

1.64e-04971205CID000005422
DrugBethanidine

ADRA2B ADRA2C

1.64e-0441202DB00217
DrugAPETx2 protein, Anthopleura elegantissima

SCN8A SCN10A

1.64e-0441202ctd:C501880
DrugAC1MPLOE

FGFR1 HS3ST3A1

1.64e-0441202CID003387244
Drug2-methoxyidazoxan

ADRA2B ADRA2C

1.64e-0441202ctd:C058525
Drug3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)-phenylamino)pyrimidin-4-yl)-1-methylurea

FGFR1 FGFR2

1.64e-0441202ctd:C568950
Diseasefamilial hemiplegic migraine 1 (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

5.18e-0831113DOID:0111181 (implicated_via_orthology)
Diseaseepilepsy (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E SLC25A4 SLC25A5 SLC25A6 SCN8A SCN10A

1.99e-071631118DOID:1826 (implicated_via_orthology)
Diseasemigraine (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

2.07e-0741113DOID:6364 (implicated_via_orthology)
Diseaseautosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

2.07e-0741113DOID:0111517 (implicated_via_orthology)
Diseasehereditary ataxia (implicated_via_orthology)

CACNA1A CACNA1B CACNA1E

1.79e-0671113DOID:0050951 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of lung

MAST4 FGFR1 FGFR2 WNK3

6.29e-06321114C0149782
Diseasedyslexia (implicated_via_orthology)

DCLK2 DCLK1

1.40e-0521112DOID:4428 (implicated_via_orthology)
DiseaseJACKSON-WEISS SYNDROME

FGFR1 FGFR2

1.40e-0521112C0795998
DiseaseFGFR2-related craniosynostosis

FGFR1 FGFR2

1.40e-0521112cv:CN231480
DiseasePFEIFFER SYNDROME

FGFR1 FGFR2

1.40e-0521112101600
DiseaseCutis Gyrata Syndrome of Beare And Stevenson

FGFR1 FGFR2

1.40e-0521112C1852406
DiseasePfeiffer type acrocephalosyndactyly

FGFR1 FGFR2

1.40e-0521112C2931888
DiseaseJackson-Weiss syndrome

FGFR1 FGFR2

1.40e-0521112cv:C0795998
DiseaseJackson-Weiss syndrome (is_implicated_in)

FGFR1 FGFR2

1.40e-0521112DOID:0111337 (is_implicated_in)
DiseasePfeiffer syndrome

FGFR1 FGFR2

1.40e-0521112cv:C0220658
DiseaseJACKSON-WEISS SYNDROME

FGFR1 FGFR2

1.40e-0521112123150
DiseasePfeiffer syndrome (is_implicated_in)

FGFR1 FGFR2

1.40e-0521112DOID:14705 (is_implicated_in)
DiseasePfeiffer syndrome (implicated_via_orthology)

FGFR1 FGFR2

1.40e-0521112DOID:14705 (implicated_via_orthology)
DiseaseCraniofacial dysostosis type 1

FGFR1 FGFR2

4.20e-0531112C2931196
Diseaseacrocephalosyndactylia (is_implicated_in)

FGFR1 FGFR2

4.20e-0531112DOID:12960 (is_implicated_in)
DiseasePfeiffer Syndrome

FGFR1 FGFR2

4.20e-0531112C0220658
DiseaseBipolar Disorder

CACNA1A CACNA1B SLC25A4 SLC6A4 ADRA2C SCN8A FGFR1 FGFR2 DCLK1

8.23e-054771119C0005586
DiseaseTWIST1-related craniosynostosis

FGFR1 FGFR2

8.37e-0541112cv:C4551902
Diseasebone disease (implicated_via_orthology)

FGFR1 FGFR2

1.39e-0451112DOID:0080001 (implicated_via_orthology)
DiseaseMental Retardation, X-Linked

UPF3B BRWD3 OPHN1

1.76e-04291113C1136249
Diseasehypertrophic cardiomyopathy (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

1.76e-04291113DOID:11984 (implicated_via_orthology)
DiseaseCraniosynostosis syndrome

FGFR1 FGFR2

2.91e-0471112cv:C0010278
Diseasemitochondrial metabolism disease (implicated_via_orthology)

SLC25A4 SLC25A5 SLC25A6

3.11e-04351113DOID:700 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN8A SCN10A

6.19e-04101112DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN8A SCN10A

6.19e-04101112DOID:0080422 (implicated_via_orthology)
DiseaseHead and Neck Carcinoma

FGFR1 FGFR2

6.19e-04101112C3887461
Diseasemeningitis

CACNA1E RCN1

7.54e-04111112MONDO_0021108
DiseaseMacrocephaly

CACNA1E BRWD3

7.54e-04111112C0221355
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN8A SCN10A

9.03e-04121112DOID:0060170 (implicated_via_orthology)
Diseasepulmonary hypertension (implicated_via_orthology)

PECAM1 SLC6A4 FGFR1

1.12e-03541113DOID:6432 (implicated_via_orthology)
Diseasevascular dementia (biomarker_via_orthology)

RPS6 FGFR1

1.24e-03141112DOID:8725 (biomarker_via_orthology)
DiseaseIntellectual Disability

CACNA1B CACNA1E RTTN BRWD3 ADRA2B SCN8A FGFR2

1.54e-034471117C3714756
DiseaseTremor, Rubral

CACNA1A SCN8A

1.63e-03161112C0750940
DiseaseAtaxia, Appendicular

CACNA1A SCN8A

1.63e-03161112C0750937
DiseaseAtaxia, Motor

CACNA1A SCN8A

1.63e-03161112C0278161
DiseaseSynostotic Posterior Plagiocephaly

FGFR1 FGFR2

1.63e-03161112C1833340
DiseaseAtaxia, Sensory

CACNA1A SCN8A

1.63e-03161112C0240991
DiseaseCraniosynostosis, Type 1

FGFR1 FGFR2

1.63e-03161112C4551902
DiseaseAcrocephaly

FGFR1 FGFR2

1.63e-03161112C0030044
DiseaseAbnormal coordination

CACNA1A SCN8A

1.63e-03161112C0520966
DiseaseTrigonocephaly

FGFR1 FGFR2

1.63e-03161112C0265535
DiseaseScaphycephaly

FGFR1 FGFR2

1.63e-03161112C0265534
DiseaseAtaxia, Truncal

CACNA1A SCN8A

1.63e-03161112C0427190
DiseaseDrug-induced agranulocytosis

SCN8A HS3ST3A1

1.63e-03161112HP_0012235
DiseaseSynostotic Anterior Plagiocephaly

FGFR1 FGFR2

1.63e-03161112C2931150
DiseaseMetopic synostosis

FGFR1 FGFR2

1.63e-03161112C1860819
DiseaseBrachycephaly

FGFR1 FGFR2

1.84e-03171112C0221356
DiseaseLimb Deformities, Congenital

COL11A2 FGFR2

1.84e-03171112C0206762
Diseaseneuroimaging measurement

CTTNBP2 DPYSL4 SH2D5 SLC6A4 DNAJA3 FZD9 AMER2 MAST4 SEC14L6 FGFR2 DCLK1

2.34e-03106911111EFO_0004346
DiseaseCraniosynostosis

FGFR1 FGFR2

2.55e-03201112C0010278
DiseasePR interval

INHBA RAP1GAP2 SLC6A4 RIC8B SCN10A FGFR1 FGFR2

2.72e-034951117EFO_0004462
DiseasePrimary microcephaly

RTTN STIL

3.08e-03221112C0431350
DiseaseDisproportionate short stature

COL11A2 FGFR1 FGFR2

3.10e-03771113C0878659
Diseaseautism spectrum disorder symptom

RIC8B DCLK2

3.37e-03231112EFO_0005426
DiseaseNonsyndromic Deafness

COL11A2 OTOGL KCNQ4

3.57e-03811113C3711374
DiseaseCleft Palate

COL11A2 FGFR1 FGFR2

3.57e-03811113C0008925
DiseaseIntrahepatic Cholangiocarcinoma

SLC5A5 FGFR2

3.67e-03241112C0345905
Diseaseairway responsiveness measurement

USP24 WDFY4

3.67e-03241112EFO_0006897
DiseaseExtrahepatic Cholangiocarcinoma

SLC5A5 FGFR2

3.67e-03241112C3805278

Protein segments in the cluster

PeptideGeneStartEntry
TILPDKRHRVKTRVL

SYT11

201

Q9BT88
AVAKSIPRKRISLKR

AMER3

141

Q8N944
IKSLRVLRVLRPLKT

CACNA1A

1341

O00555
VIKHKVRDLVPSSRV

FAM234A

511

Q9H0X4
ISKTAVAPIERVKLL

SLC25A6

21

P12236
RTKIPVSKVLVRRVS

AMER2

636

Q8N7J2
AAAVRKPIVLKRIVA

CDCA5

51

Q96FF9
FVKVSSPKVLQRLIR

CACNB3

291

P54284
IKTIKSLRVLRVLRP

CACNA1E

1251

Q15878
SLRVLRVLRPLKTIK

CACNA1E

1256

Q15878
KRRTVVTPVILTKID

ADGRA3

661

Q8IWK6
LKRTPRRVKATIVAV

ADRA2C

161

P18825
ISKTAVAPIERVKLL

SLC25A5

21

P05141
PIVKAAKIVTDVLLR

BRWD3

1226

Q6RI45
NSKRTPRRIKCIILT

ADRA2B

121

P18089
IPSRLILEIKKQLRA

CCDC180

866

Q9P1Z9
GPASVRKLALRIKVV

C2CD4C

381

Q8TF44
TIKSLRVLRVLRPLK

CACNA1B

1246

Q00975
IARIALKALIRGKVS

CERS5

331

Q8N5B7
VTKLVLLRQRPAKLS

ADAMTS17

281

Q8TE56
VPKANRTRTKVTIRL

INHBA

161

P08476
VLSTLSGRPVKIRKI

RCL1

21

Q9Y2P8
VLAPRVLRAKPTVRK

RCN1

21

Q15293
TVPLVRRVKTNVPVK

RALY

151

Q9UKM9
KKIPIVRRFVSSLKR

RFX6

371

Q8HWS3
VAAKLLTVRVSVPII

SLC34A3

146

Q8N130
VTARRHKPITISKRL

OPHN1

581

O60890
HKPITISKRLLRERT

OPHN1

586

O60890
KPATLRLSVIGRLKT

LRRC9

801

Q6ZRR7
IKGRKTLATPAVRRL

DBT

166

P11182
HKLTKRIPLRRQVTV

FGFR2

416

P21802
ITPVIRAKLSKLVRE

SLC46A1

371

Q96NT5
TKLIVVVRDPVTRAI

HS3ST3B1

221

Q9Y662
TSIPRRKKLICVTEV

LYVE1

191

Q9Y5Y7
LVTPLKSRKVIEQRC

MIS18BP1

651

Q6P0N0
KTVIRSIRILKFLVA

KCNQ4

531

P56696
KLVTIIRSGVKPRKA

DCLK1

186

O15075
IRSGVKPRKAVRILL

DCLK1

191

O15075
VIRSGVKPRKAVRIL

DCLK2

201

Q8N568
VKVAVRIRPLLCKEA

KIF27

6

Q86VH2
CEKLSIVRKRVSPTL

OR4A16

301

Q8NH70
VLILRTVLGIVARKK

OR51T1

221

Q8NGJ9
ASSVPRSKILTVRVI

PECAM1

581

P16284
TIVTLKKTIRISPHR

DDIAS

551

Q8IXT1
ISAVLPTAFRVAKKR

GDAP1

301

Q8TB36
VTLIVDCKKRVTRPL

COL11A2

161

P13942
KRQSLSTRKPVIIAV

MYCLP1

171

P12525
TVLLRKESRKLIVQP

DPP3

661

Q9NY33
TKLIVVVRDPVTRAI

HS3ST3A1

236

Q9Y663
PVDTVKLRIEKTVIR

LRIT3

56

Q3SXY7
KKLITVQVVPVAARL

IRF5

411

Q13568
PLVARKKVFRASVAL

ITPRID2

1141

P28290
LGKARRKVTVLVLVV

NPBWR2

251

P48146
LPRAKRKSVRTIAVV

P2RY2

236

P41231
TPLAVICVVKIIRRT

PLPP4

61

Q5VZY2
EIAKRIPIITSAKTL

MFAP3

201

P55082
IVKDLAKPRLRRATI

P4HA1

351

P13674
VTKCSLVRPKVVRSV

MCM3

131

P25205
SKVVIRRLPPTLTKE

UPF3B

51

Q9BZI7
RPTLVLVEKTVSRIA

PIKFYVE

746

Q9Y2I7
PALKTIVILTLRKVA

FZD9

366

O00144
KKSIPRITSDRLLIR

DPYSL4

6

O14531
TRRPVSLAKVLKTAR

CBX2

176

Q14781
PAEVKDLTKRIRTVL

DOCK10

1651

Q96BY6
LPRKTKDRRLVSISV

CTTNBP2

281

Q8WZ74
KLAKSIPLRRQVTVS

FGFR1

416

P11362
LVTIIRSGVKPRKAV

DCX

181

O43602
KRIVRRASLPSLSLK

REXO1L1P

266

Q8IX06
KQLVRKILIVIARPA

MAST4

466

O15021
VLFITLRRSKKEPLI

CDH18

631

Q13634
IHIKIRVPKRLTSRQ

DNAJA3

406

Q96EY1
LKSLIVVRAPKLFAV

SEC14L6

186

B5MCN3
TTPIHKIIVNRLARK

OTOGL

1606

Q3ZCN5
VDLTKLAVTKKRVRP

OSBPL11

651

Q9BXB4
LSVKKTRDLVVRLPR

MTERF3

271

Q96E29
IIRAILRIPSVSKKY

OR1D2

221

P34982
GKSRPIKILTRLTII

RPP30

66

P78346
LRLLLVKKPSVRSLA

RTTN

761

Q86VV8
IKRRVKSVVLVILLG

TAS2R30

121

P59541
LKRRVKSVILVVLLG

TAS2R45

121

P59539
LKRRVKSVVLVILLG

TAS2R46

121

P59540
PKRKIPTSRVITLKA

NUGGC

221

Q68CJ6
KPVRLSVAIPKASRV

TRNAU1AP

166

Q9NX07
TKAPKIQRLVTPRVL

RPS6

171

P62753
VILRSKLKTVHERIP

RAP1GAP2

196

Q684P5
GSLRKTRPLVVKTSL

RPP38

11

P78345
ASKIIILKRTSLPTV

TMEM191A

91

Q9H0A3
AVVRLLDRSPKTVVV

NXPE3

466

Q969Y0
RILSRDKKVLVPVTT

RIC8B

71

Q9NVN3
QLALSTSLVIRKVPK

PRDM11

356

Q9NQV5
SPTLVRKKAIRSKVI

SH2D5

231

Q6ZV89
RPLRLLVATKAKEII

PREX1

696

Q8TCU6
RPITFTLKIVNVLKR

SLFN11

291

Q7Z7L1
QTLFRRVKTLLIKAP

SLC25A41

16

Q8N5S1
ILTIVRIPSASGRKK

OR6J1

221

Q8NGC5
KLITPAVVSERLKIR

RPS25

66

P62851
RKVICIPKSITPSRI

AKR1A1

256

P14550
VSKTAVAPIERVKLL

SLC25A4

21

P12235
RNPKLVVTEKTIRLA

STIL

51

Q15468
ASPKAITKPVRRTVV

TMF1

76

P82094
STKKLTVQRFPRILV

USP21

446

Q9UK80
ALVKPIRNIITAKRS

UNC80

231

Q8N2C7
TITPPAVKRNVRKII

TMPRSS11F

266

Q6ZWK6
IRRKLKKGAVPSVSL

THAP9

76

Q9H5L6
RSLAPRKLVIISKGL

SLC5A5

376

Q92911
TFRVLRALKTVSVIP

SCN10A

216

Q9Y5Y9
RRPLSTSEKVKVRTL

RNF123

696

Q5XPI4
LRARSISAVKIIPVK

SORBS1

31

Q9BX66
TRRILIPFSQRKLTK

USP49

421

Q70CQ1
KSLLRILVTPKGRAA

WDFY4

626

Q6ZS81
LVIRAKISSEKVVPA

TIMP4

46

Q99727
TFRVLRALKTISVIP

SCN8A

221

Q9UQD0
LRVLVSTKPRETVKI

PREX2

666

Q70Z35
ALERVVRISAKPTKR

RGS14

381

O43566
SRPPLSRLVVVKKAK

YJU2

256

Q9BW85
RITVKRTCIKSLPSV

USP24

1866

Q9UPU5
ARALVNPVKLRKLVI

VPS13B

3576

Q7Z7G8
LKSSLIRKPRIVSRG

ZNF879

166

B4DU55
PFETVISVKAKIRRL

ZFAND4

46

Q86XD8
RGKSLRVQKIRPSIL

TXNIP

251

Q9H3M7
RLIITPGTFKERIIK

SLC6A4

596

P31645
TQKSVAPLKLRRTIA

USP6

596

P35125
KVLDIVKTSIRTVLP

TTLL7

736

Q6ZT98
VASPRIISLAKPKVR

THEG

331

Q9P2T0
LEKTRKLVLRPALAV

TMPPE

156

Q6ZT21
AKSIRDRVTPIKKTR

WNK3

481

Q9BYP7