Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	triplex DNA binding	DDX11L8 DDX11	1.02e-04	4	83	2	GO:0045142
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	DMC1 MCM3 CHD9 DDX11L8 DDX11	1.88e-04	127	83	5	GO:0008094
GeneOntologyMolecularFunction	single-stranded DNA binding	DMC1 MCM3 NABP1 DDX11L8 DDX11	2.41e-04	134	83	5	GO:0003697
GeneOntologyMolecularFunction	lysine-acetylated histone binding	PSME4 BAZ2A SIRT1	2.59e-04	30	83	3	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	PSME4 BAZ2A SIRT1	2.86e-04	31	83	3	GO:0140033
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	DMC1 SLFN13 DDX60 MCM3 CHD9 GNAS ARHGAP35 ATP12A DDX11L8 RRAGC DDX11	3.54e-04	775	83	11	GO:0017111
GeneOntologyMolecularFunction	ATP hydrolysis activity	DMC1 SLFN13 DDX60 MCM3 CHD9 ATP12A DDX11L8 DDX11	4.93e-04	441	83	8	GO:0016887
GeneOntologyMolecularFunction	helicase activity	DDX60 MCM3 CHD9 DDX11L8 DDX11	5.14e-04	158	83	5	GO:0004386
GeneOntologyMolecularFunction	adenylate cyclase regulator activity	GNAS ADGRV1	6.03e-04	9	83	2	GO:0010854
GeneOntologyMolecularFunction	pyrophosphatase activity	DMC1 SLFN13 DDX60 MCM3 CHD9 GNAS ARHGAP35 ATP12A DDX11L8 RRAGC DDX11	6.88e-04	839	83	11	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	DMC1 SLFN13 DDX60 MCM3 CHD9 GNAS ARHGAP35 ATP12A DDX11L8 RRAGC DDX11	6.95e-04	840	83	11	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	DMC1 SLFN13 DDX60 MCM3 CHD9 GNAS ARHGAP35 ATP12A DDX11L8 RRAGC DDX11	6.95e-04	840	83	11	GO:0016818
GeneOntologyMolecularFunction	5'-3' DNA helicase activity	DDX11L8 DDX11	9.16e-04	11	83	2	GO:0043139
GeneOntologyMolecularFunction	extracellular matrix structural constituent	ENAM COL6A3 MXRA5 VWA5A MUC3A	1.12e-03	188	83	5	GO:0005201
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	DMC1 TARS3 SLFN13 DDX60 POLR2E MCM3 CHD9 DDX11L8 DDX11	1.42e-03	645	83	9	GO:0140640
GeneOntologyMolecularFunction	G-quadruplex DNA binding	DDX11L8 DDX11	1.50e-03	14	83	2	GO:0051880
GeneOntologyBiologicalProcess	nucleolar chromatin organization	BAZ2A SIRT1 DDX11	8.40e-06	11	78	3	GO:1990700
GeneOntologyBiologicalProcess	DNA repair	DMC1 PPP4C PSME4 USP9X MCM3 NABP1 NEURL4 DDX11L8 SIRT1 NSMCE4A DDX11	3.11e-05	648	78	11	GO:0006281
GeneOntologyCellularComponent	microtubule organizing center	CEP104 PPP4C CCNB3 USP9X FRMD8 MCM3 UPF3B ARHGAP35 NEURL4 DDX11L8 FRMD8P1 CCNB1 DDX11	4.94e-05	919	81	13	GO:0005815
GeneOntologyCellularComponent	rDNA heterochromatin	BAZ2A SIRT1	1.47e-04	5	81	2	GO:0033553
GeneOntologyCellularComponent	centrosome	CEP104 PPP4C CCNB3 USP9X FRMD8 MCM3 UPF3B DDX11L8 FRMD8P1 CCNB1 DDX11	1.82e-04	770	81	11	GO:0005813
GeneOntologyCellularComponent	Derlin-1 retrotranslocation complex	SEL1L HM13	4.09e-04	8	81	2	GO:0036513
GeneOntologyCellularComponent	Ctf18 RFC-like complex	DDX11L8 DDX11	6.54e-04	10	81	2	GO:0031390
GeneOntologyCellularComponent	sarcolemma	COL6A3 SVIL SGCE GNAS CDH2	8.62e-04	190	81	5	GO:0042383
GeneOntologyCellularComponent	spindle pole	CEP104 IK DDX11L8 CCNB1 DDX11	1.21e-03	205	81	5	GO:0000922
GeneOntologyCellularComponent	chromatin silencing complex	BAZ2A SIRT1	1.31e-03	14	81	2	GO:0005677
HumanPheno	Ectopic ossification in muscle tissue	ACVR1 GNAS	2.31e-05	2	25	2	HP:0011987
Domain	-	CEP104 PSME4 USP9X ANKAR INTS4 ZYG11B	3.56e-04	222	79	6	1.25.10.10
Domain	Rap_GAP_dom	RALGAPB SIPA1L2	9.48e-04	11	79	2	IPR000331
Domain	RAPGAP	RALGAPB SIPA1L2	9.48e-04	11	79	2	PS50085
Domain	ARM-like	CEP104 PSME4 USP9X ANKAR INTS4 ZYG11B	9.93e-04	270	79	6	IPR011989
Domain	-	DMC1 SLFN13 SULT1C3 DDX60 MCM3 CHD9 GNAS ARHGAP35 RRAGC DDX11	1.16e-03	746	79	10	3.40.50.300
Domain	Cyclin_C	CCNB3 CCNB1	2.31e-03	17	79	2	PF02984
Domain	Cyclin_C-dom	CCNB3 CCNB1	2.31e-03	17	79	2	IPR004367
Domain	Cyclin_C	CCNB3 CCNB1	2.31e-03	17	79	2	SM01332
Domain	P-loop_NTPase	DMC1 SLFN13 SULT1C3 DDX60 MCM3 CHD9 GNAS ARHGAP35 RRAGC DDX11	2.98e-03	848	79	10	IPR027417
Domain	ARM-type_fold	CEP104 PSME4 USP9X ANKAR INTS4 ZYG11B	3.13e-03	339	79	6	IPR016024
Domain	HEAT_REPEAT	CEP104 PSME4 INTS4	3.25e-03	70	79	3	PS50077
Pubmed	Expression of genes involved in mammalian meiosis during the transition from egg to embryo.	DMC1 MCM3 SIRT1 CCNB1	1.23e-06	33	84	4	11389549
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PPP4C PTPRG USP9X SVIL POLR2E RALGAPB TNRC6A INTS4 ZYG11B PRKCSH IK ADGRL2 NEURL4	1.37e-06	1049	84	13	27880917
Pubmed	Proteomic analysis identifies novel binding partners of BAP1.	KLHDC2 POLR2E NAP1L4 GNAS LANCL2	1.52e-06	80	84	5	34591877
Pubmed	Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network.	SEL1L RTN4 PRKCSH EXTL3 ATP12A HM13 SIRT1	5.69e-06	282	84	7	35007762
Pubmed	80K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5).	PRKCSH TRPV5	5.76e-06	2	84	2	15100231
Pubmed	SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex.	PPP4C SIRT1	5.76e-06	2	84	2	37309898
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	VWA5A USP9X MRPS26 POLR2E TNRC6A NAP1L4 GNAS IK SIRT1	7.13e-06	547	84	9	37267103
Pubmed	Unraveling the genetic landscape of bladder development in mice.	SOX11 ARNT2 CDH2	7.44e-06	16	84	3	19303107
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TXNIP USP9X SVIL MCM3 GNAS IK NEURL4	1.12e-05	313	84	7	38270169
Pubmed	Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C.	GNAS ADGRV1	1.73e-05	3	84	2	24191038
Pubmed	Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.	RPS6KB1 SIRT1	1.73e-05	3	84	2	24652283
Pubmed	FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.	FRMD8 FRMD8P1	1.73e-05	3	84	2	37527040
Pubmed	Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation.	DDX11L8 DDX11	1.73e-05	3	84	2	17611414
Pubmed	Mammalian ChlR1 has a role in heterochromatin organization.	DDX11L8 DDX11	1.73e-05	3	84	2	21854770
Pubmed	The ADAM17 sheddase complex regulator iTAP/Frmd8 modulates inflammation and tumor growth.	FRMD8 FRMD8P1	1.73e-05	3	84	2	36720499
Pubmed	Sirt1/Nrf2 pathway is involved in oocyte aging by regulating Cyclin B1.	SIRT1 CCNB1	1.73e-05	3	84	2	30368232
Pubmed	ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas.	PPP4C RALGAPB ARHGAP35 IK SIRT1	2.52e-05	142	84	5	30232004
Pubmed	USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.	USP9X RPS6KB1	3.45e-05	4	84	2	28341829
Pubmed	Phosphorylation regulates SIRT1 function.	SIRT1 CCNB1	3.45e-05	4	84	2	19107194
Pubmed	Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.	SOX11 CDH2	3.45e-05	4	84	2	20847309
Pubmed	p16(INK4a) suppression by glucose restriction contributes to human cellular lifespan extension through SIRT1-mediated epigenetic and genetic mechanisms.	RPS6KB1 SIRT1	3.45e-05	4	84	2	21390332
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SEL1L GRAMD1B PPP4C DDX60 MRPS26 RTN4 POLR2E NAP1L4 MCM3 EXTL3 GNAS ADGRL2 CCNB1	4.03e-05	1440	84	13	30833792
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	GRAMD1B BAZ2A MRPS26 RTN4 RALGAPB NAP1L4 PRKCSH GNAS HM13 SIPA1L2 ADGRL2 NEURL4 SIRT1	5.60e-05	1487	84	13	33957083
Pubmed	Reversible acetylation of the chromatin remodelling complex NoRC is required for non-coding RNA-dependent silencing.	BAZ2A SIRT1	5.74e-05	5	84	2	19578370
Pubmed	Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint.	CCNB3 CCNB1	5.74e-05	5	84	2	10958988
Pubmed	FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.	FRMD8 FRMD8P1	5.74e-05	5	84	2	29897336
Pubmed	iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.	FRMD8 FRMD8P1	5.74e-05	5	84	2	29897333
Pubmed	Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard.	CCNB3 CCNB1	5.74e-05	5	84	2	9094673
Pubmed	Polyhydramnios, Transient Antenatal Bartter's Syndrome, and MAGED2 Mutations.	NAP1L4 GNAS	5.74e-05	5	84	2	27120771
Pubmed	Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression.	CCNB3 CCNB1	5.74e-05	5	84	2	11878934
Pubmed	The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle.	CCNB3 CCNB1	5.74e-05	5	84	2	7666531
Pubmed	LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway.	LANCL2 SIRT1	5.74e-05	5	84	2	34098144
Pubmed	Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene.	GNAS CDH2	5.74e-05	5	84	2	8270638
Pubmed	Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity.	CCNB3 CCNB1	5.74e-05	5	84	2	7474080
Pubmed	Defining human ERAD networks through an integrative mapping strategy.	SEL1L PSME4 KLHDC2 RTN4 HM13	6.46e-05	173	84	5	22119785
Pubmed	Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.	SEL1L PPP4C USP9X MRPS26 POLR2E NAP1L4 COX11 PRKCSH SIRT1 CCNB1	8.30e-05	931	84	10	27432908
Pubmed	Blood-induced bone loss in murine hemophilic arthropathy is prevented by blocking the iRhom2/ADAM17/TNF-α pathway.	FRMD8 FRMD8P1	8.59e-05	6	84	2	29776906
Pubmed	Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.	CCNB3 CCNB1	8.59e-05	6	84	2	7474100
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP9X TNRC6A MCM3 UPF3B GNAS SIPA1L2 SIRT1 DDX11	8.99e-05	588	84	8	38580884
Pubmed	Loss of Elp1 perturbs histone H2A.Z and the Notch signaling pathway.	NTRK1 SIRT1	1.20e-04	7	84	2	34590699
Pubmed	Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity.	GNAS CDH2	1.20e-04	7	84	2	26674379
Pubmed	HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator.	CCNB3 CCNB1	1.20e-04	7	84	2	9560267
Pubmed	Acetylation of FOXM1 is essential for its transactivation and tumor growth stimulation.	SIRT1 CCNB1	1.20e-04	7	84	2	27542221
Pubmed	HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle.	CCNB3 CCNB1	1.20e-04	7	84	2	9520381
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	SEL1L RTN4 NAP1L4 PRKCSH GNAS SIPA1L2 ADGRL2 LANCL2 SIRT1 CCNB1	1.20e-04	974	84	10	28675297
Pubmed	Global landscape of HIV-human protein complexes.	SEL1L RTN4 NAP1L4 PRKCSH IK HM13 SIRT1	1.22e-04	457	84	7	22190034
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	USP9X NTRK1 RPS6KB1 RTN4 ACVR1	1.25e-04	199	84	5	36688959
Pubmed	The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.	DDX11L8 DDX11	1.60e-04	8	84	2	22678773
Pubmed	Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.	RPS6KB1 LANCL2	1.60e-04	8	84	2	25273559
Pubmed	Microtubule-associated protein/microtubule affinity-regulating kinase 4 (MARK4) is a negative regulator of the mammalian target of rapamycin complex 1 (mTORC1).	RPS6KB1 RRAGC	1.60e-04	8	84	2	23184942
Pubmed	Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1.	SIRT1 CCNB1	1.60e-04	8	84	2	37291217
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	PTPRG NTRK1 CDH2	2.04e-04	47	84	3	19167335
Pubmed	Essential role of Cdc42 in cardiomyocyte proliferation and cell-cell adhesion during heart development.	CDH2 CCNB1	2.05e-04	9	84	2	27986432
Pubmed	SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.	RPS6KB1 UPF3B	2.05e-04	9	84	2	18423201
Pubmed	p62 is a key regulator of nutrient sensing in the mTORC1 pathway.	RPS6KB1 RRAGC	2.05e-04	9	84	2	21981924
Pubmed	Interplay between protein acetylation and ubiquitination controls MCL1 protein stability.	USP9X SIRT1	2.56e-04	10	84	2	34758305
Pubmed	FMRP regulates multipolar to bipolar transition affecting neuronal migration and cortical circuitry.	CDH2 CYP46A1	2.56e-04	10	84	2	25402856
Pubmed	Sox11 regulates survival and axonal growth of embryonic sensory neurons.	SOX11 NTRK1	2.56e-04	10	84	2	21117150
Pubmed	A genome-wide association study of aging.	COL6A3 VWA5A	3.13e-04	11	84	2	21782286
Pubmed	A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner.	RPS6KB1 CCNB1	3.13e-04	11	84	2	17475776
Pubmed	Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr.	CCNB3 CCNB1	3.75e-04	12	84	2	7494303
Pubmed	Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).	USP9X RPS6KB1	3.75e-04	12	84	2	22544753
Pubmed	Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.	TRIM42 INTS4 MCM3 SGCE PRKCSH ACVR1 GNAS HM13	4.33e-04	742	84	8	26871637
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	PPP4C USP9X RTN4 NAP1L4 GNAS LANCL2 SIRT1	4.72e-04	571	84	7	37167062
Pubmed	Protein phosphatase 4 maintains the survival of primordial follicles by regulating autophagy in oocytes.	PPP4C RPS6KB1	5.15e-04	14	84	2	39245708
Pubmed	The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform.	GNAS CDH2	5.15e-04	14	84	2	9151674
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RPS6KB1 RRAGC	5.15e-04	14	84	2	28716898
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	TXNIP USP9X MCM3	5.33e-04	65	84	3	29378950
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	USP9X INTS4 UPF3B CCNB1 NSMCE4A	6.09e-04	281	84	5	24163370
Pubmed	Global comparative transcriptome analysis of cartilage formation in vivo.	SOX11 CDH2	6.77e-04	16	84	2	19272164
Pubmed	Streamlined analysis schema for high-throughput identification of endogenous protein complexes.	POLR2E INTS4 NABP1	6.90e-04	71	84	3	20133760
Pubmed	Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.	EID2B NSMCE4A	7.66e-04	17	84	2	21364888
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	USP9X TNRC6A ARHGAP35 ADGRL2	7.67e-04	169	84	4	31462741
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	SOX11 VWA5A RPS6KB1 ANKAR ADGRV1 ATP12A ADGRL2 CDH2	7.92e-04	814	84	8	23251661
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	MRPS26 RTN4 SVIL POLR2E MCM3 CHD9 UPF3B GNAS IK LANCL2	8.43e-04	1247	84	10	27684187
Pubmed	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome.	DMC1 CCNB1	8.60e-04	18	84	2	31358751
Pubmed	MORC2B is essential for meiotic progression and fertility.	DMC1 CCNB3	8.60e-04	18	84	2	29329290
Pubmed	Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice.	RPS6KB1 CCNB1	8.60e-04	18	84	2	31064784
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	PPP4C PSME4 USP9X POLR2E NAP1L4 MCM3 GNAS IK HM13 DDX11	8.96e-04	1257	84	10	37317656
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	PTPRG TNRC6A ADGRL2 CDH2 LANCL2	9.06e-04	307	84	5	37499664
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	USP9X MRPS26 TNRC6A NAP1L4 SIPA1L2 NEURL4 CCNB1	9.13e-04	639	84	7	23443559
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	BAZ2A MRPS26 RTN4 COX11 PRKCSH UPF3B GNAS HM13 NEURL4 SIRT1 CCNB1	9.36e-04	1496	84	11	32877691
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	COL6A3 USP9X PRKCSH ATP12A	9.50e-04	179	84	4	36261009
Pubmed	Meioc maintains an extended meiotic prophase I in mice.	DMC1 CCNB3	9.60e-04	19	84	2	28380054
Pubmed	Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins.	COL6A3 SEMA3D	9.60e-04	19	84	2	29196262
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	SEL1L GRAMD1B RTN4 PRKCSH HM13 ADGRL2	9.64e-04	468	84	6	31056421
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	KLHDC2 USP9X RTN4 INTS4 SGCE PRKCSH EXTL3 ACVR1 ATP12A	1.05e-03	1061	84	9	33845483
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	SOX11 PSME4 NAP1L4 COX11 GNAS	1.12e-03	322	84	5	26514267
Pubmed	Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.	MXRA5 USP9X ADGRV1	1.12e-03	84	84	3	15203218
Pubmed	Temporal and spatial transcriptional programs in murine kidney development.	RPS6KB1 RTN4	1.17e-03	21	84	2	15998744
Pubmed	Repression of cyclin D1 expression is necessary for the maintenance of cell cycle exit in adult mammalian cardiomyocytes.	MCM3 CCNB1	1.17e-03	21	84	2	24821722
Pubmed	Differential expression of a set of genes in follicular and classic variants of papillary thyroid carcinoma.	MCM3 IK	1.17e-03	21	84	2	21509594
Pubmed	SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.	SEMA3D CDH2	1.17e-03	21	84	2	30021842
Pubmed	Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.	KLHDC2 POLR2E MCM3 ZYG11B PRKCSH ADGRV1	1.28e-03	495	84	6	28581483
Pubmed	B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS.	NTRK1 RPS6KB1	1.29e-03	22	84	2	24733831
Pubmed	Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.	USP9X RTN4	1.29e-03	22	84	2	37225996
Pubmed	The protein interaction landscape of the human CMGC kinase group.	USP9X POLR2E SIPA1L2 NEURL4 SIRT1 CCNB1 NSMCE4A	1.48e-03	695	84	7	23602568
Pubmed	Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.	SEL1L CDH2	1.54e-03	24	84	2	24347629
Pubmed	hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice.	DMC1 CDH2	1.54e-03	24	84	2	36718792
Pubmed	Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome.	SOX11 CDH2	1.54e-03	24	84	2	17697936
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	TXNIP GRAMD1B MYLK3 SVIL B4GALNT3 ADGRL2 CDH2	7.12e-08	189	84	7	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	LV\|World / Chamber and Cluster_Paper	TXNIP GRAMD1B MYLK3 B4GALNT3 ADGRL2 CDH2	1.18e-06	180	84	6	5ac6f485a58bb29462fec02dfbe8eb70864eafe3
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	GRAMD1B MYLK3 SVIL B4GALNT3 ADGRL2 CDH2	1.62e-06	190	84	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SOX11 COL6A3 PTPRG SLFN13 ARNT2 ADGRL2	1.83e-06	194	84	6	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_C\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SOX11 PTPRG DDX60 ADGRL2 PIGZ	1.16e-05	156	84	5	6c8f442ed94ae31e6832b68137e98ae78091ac6c
ToppCell	droplet-Heart-nan-18m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRAMD1B COL6A3 SEMA3D ADGRV1 CYP46A1	1.57e-05	166	84	5	9adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DMC1 CFAP91 SLFN13 MCM3 DDX11	1.71e-05	169	84	5	121768fc51fc3441ec725346a1bbe29e21d05971
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFAP91 SGCE GNAS CDH2 CCNB1	2.02e-05	175	84	5	fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	GRAMD1B MYLK3 B4GALNT3 ADGRL2 CDH2	2.78e-05	187	84	5	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	GRAMD1B MYLK3 B4GALNT3 ADGRL2 CDH2	2.85e-05	188	84	5	0758b474457efa36488e0195f7357100f4b6a090
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP USP9X TNRC6A GNAS CDH2	3.08e-05	191	84	5	fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCell	LV-06._Ventricular_Cardiomyocyte_II\|LV / Chamber and Cluster_Paper	MYLK3 SVIL B4GALNT3 ADGRL2 CDH2	3.08e-05	191	84	5	25f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	MYLK3 SVIL B4GALNT3 ADGRL2 CDH2	3.16e-05	192	84	5	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	droplet-Pancreas-Endocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP USP9X TNRC6A GNAS CDH2	3.16e-05	192	84	5	4510aa262da8dcf7c944b3907a51aba5a9397a4e
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	GRAMD1B MYLK3 SVIL B4GALNT3 CDH2	3.40e-05	195	84	5	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	GRAMD1B MYLK3 SVIL B4GALNT3 CDH2	3.40e-05	195	84	5	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	SOX11 COL6A3 PTPRG SLFN13 ADGRL2	3.40e-05	195	84	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MXRA5 RTN4 B4GALNT3 ATP12A TRPV5	3.40e-05	195	84	5	3f517c6fc372bdcaf45b3af373414f13cbebd4ba
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MXRA5 RTN4 B4GALNT3 ATP12A TRPV5	3.40e-05	195	84	5	e94bac6a5c788ee160d7feaf2a3c512a3691f995
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 MXRA5 PTPRG SGCE ADGRL2	3.65e-05	198	84	5	7582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell	ILEUM-non-inflamed-(8)_Fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	COL6A3 MXRA5 SGCE ADGRL2 DDX11	3.74e-05	199	84	5	d9d7f36b4b5592b7855448730044c90997b55499
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Neuron\|1m / Sample Type, Dataset, Time_group, and Cell type.	SOX11 PTPRG NTRK1 RTN4 LANCL2	3.83e-05	200	84	5	be1e153119ca4946b4eaef6037e8465f5c00ca6f
Disease	Warsaw breakage syndrome (implicated_via_orthology)	DDX11L8 DDX11	2.28e-05	3	82	2	DOID:0060535 (implicated_via_orthology)
Disease	Ceroid lipofuscinosis, neuronal 1, infantile	RPS6KB1 SIRT1	3.38e-04	10	82	2	C2931673
Disease	Lung Injury	NTRK1 SIRT1	1.55e-03	21	82	2	C0273115
Disease	Chronic Lung Injury	NTRK1 SIRT1	1.55e-03	21	82	2	C2350344
Disease	mean platelet volume	GRAMD1B BAZ2A SVIL TNRC6A INTS4 MCM3 CHD9 GNAS NABP1	2.08e-03	1020	82	9	EFO_0004584
Disease	glaucoma (biomarker_via_orthology)	TXNIP NTRK1	2.75e-03	28	82	2	DOID:1686 (biomarker_via_orthology)
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	ADGRL2 CDH2	2.75e-03	28	82	2	DOID:1094 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PVEMQIFFYNPDDFD	PTPRG	171	P23470
EDMSEVFEYVPVFDP	B4GALNT3	616	Q6L9W6
PPAGNFAAEYMEEVA	ARMH2	91	H3BNL8
ELYDSFPDQNFEVMP	BAZ2A	166	Q9UIF9
FYDVVPNDPSFEDMR	ACVR1	431	Q04771
PEMDEYFVCTLFNPT	ADGRV1	3161	Q8WXG9
PFQMENTDCYLPDAF	ADGRL2	76	O95490
VFYIAADMASPEAPE	HSD11B1L	81	Q7Z5J1
YDSPEMPENEATFAI	DMC1	316	Q14565
DDEDYVPPDDDFNTM	GRAMD1B	231	Q3KR37
IDEDSSDPSFNPMYA	CCNB3	1116	Q8WWL7
TDASFQMPKEVYEDP	CFAP91	121	Q7Z4T9
YNIEDFADLGMFPPF	ARNT2	701	Q9HBZ2
FFDTAEPDMDDPAYI	INTS4	531	Q96HW7
DPNSPEETAVFMKYA	ANKAR	226	Q7Z5J8
PMSFVLEFHFEPNDY	NAP1L4	201	Q99733
AAFMDNPFEFNPEDP	NTRK1	376	P04629
APDDDVAMDEPFLQF	FRMD8	111	Q9BZ67
MPPYDEQTQAFIDAA	PRKCSH	356	P14314
PETYSFDIDAMNFPT	ATP12A	581	P54707
APDDDVAMDEPFLQF	FRMD8P1	111	Q9BZ68
EAEMEERAFVNPFPD	LANCL2	16	Q9NS86
QDLMGDVYFFDIPFP	DDX60	1331	Q8IY21
AFDADPPQMDFAAVA	EID2B	131	Q96D98
EMPFSPQLESEYEQV	MUC3A	3091	Q02505
PEVVNYEFVSFPTDM	MYLK3	681	Q32MK0
EFFNYNPVEDFSMPP	PCED1A	356	Q9H1Q7
YPAPDFRDREAEDMA	RPS6KB1	11	P23443
TEMFSYEESNPKDPA	HM13	341	Q8TCT9
PFTPYSIQEDFMAEL	DDX11	16	Q96FC9
DPYDFSDTEEEMPQV	MCM3	706	P25205
LQPMPEHDYFEFFSN	UPF3B	71	Q9BZI7
ADMEEEPFNPDYVEV	CHD9	761	Q3L8U1
MYPPEIGDFAFVTDN	CCNB1	261	P14635
PLDDLAFDMYQDPEV	CEP104	196	O60308
MDTYFEDPLTFNPDR	CYP46A1	401	Q9Y6A2
NPQEEVDMPVFFYID	COX11	226	Q9Y6N1
VDMPVFFYIDPEFAE	COX11	231	Q9Y6N1
FFYIDPEFAEDPRMI	COX11	236	Q9Y6N1
RSFEEEMEGDPPADY	EXTL3	361	O43909
YYQPEEDDEMPFICS	CACNA1I	256	Q9P0X4
GPVEAFDFDEYQPEM	COL6A3	1896	P12111
PFTPYSIQEDFMAEL	DDX11L8	16	A8MPP1
DTFQFPDMDHSYVPS	CCDC183	496	Q5T5S1
NQIYPEADFADSMEP	CCDC144B	586	Q3MJ40
DDLPGPAFESYESME	KLHDC2	11	Q9Y2U9
RPPYYSEEMFEQDFE	ENAM	211	Q9NRM1
NQIYPEADFADSMEP	CCDC144A	586	A2RUR9
MDADPEFPPDFAEAF	SLFN13	351	Q68D06
NDNPPEFTAMTFYGE	CDH2	376	P19022
PEDLEFPNTMTDIDY	NEURL4	786	Q96JN8
VPNETYFSFDEFMVP	PGBD3	261	Q8N328
PAVDPAEFFVLMERY	MRPS26	46	Q9BYN8
VEAPMREEYADFKPF	RTN4	376	Q9NQC3
PAPDFSDYSEMAKVE	RTN4	711	Q9NQC3
PPIENGFYYDMFIED	TARS3	256	A2RTX5
FEFPDYCTPELSEMI	SOX11	411	P35716
FEFPRELDMEPYTVA	USP9X	1816	Q93008
DSFEMEFYEVITSPP	TRIM42	631	Q8IWZ5
DFPGQMDFFDPTFDY	RRAGC	116	Q9HB90
EFCMVYSEVPNFSEP	NABP1	101	Q96AH0
SFMPDPQNLEEFYEK	SULT1C3	156	Q6IMI6
FQFETEVPDAYNMVP	UBE2F	81	Q969M7
DDPTDQMFVFFPEEP	POLR2E	66	P19388
MDEDFDVIFDPYAPK	SVIL	1326	O95425
YDMAAEASPDAQVPV	SEL1L	691	Q9UBV2
SVMNVPDFDFPPEFY	GNAS	776	Q5JWF2
FKDPPRIMQSDDYFA	SIPA1L2	21	Q9P2F8
MYGFVEPYPDNTDDT	SETD6	296	Q8TBK2
PDPQAMFDIEYFRKD	SIRT1	291	Q96EB6
DPDTPMSFFDFVVDP	NSMCE4A	281	Q9NXX6
GFDPSDYAEPMDAVV	ARHGAP35	1081	Q9NRY4
MSAEDFPLPYQAEFF	SGCE	151	O43556
PYMFECITENFSIDP	PDXP	216	Q96GD0
DPQQPFASVMTDEYL	SEMA3D	186	O95025
PECEMVAYRSFNPFF	ZYG11B	641	Q9C0D3
PLEAFFVFPMDEDSA	VWA5A	46	O00534
PPEADMNIFEDIGDY	IK	311	Q13123
YVHPDEFFQSPEVMA	PIGZ	56	Q86VD9
RPYFPADATAEMLEE	PSME4	181	Q14997
SNPMFDASEFPDNYE	RALGAPB	496	Q86X10
MYKPIFSPEFEFEEE	ZC2HC1C	281	Q53FD0
DGSQDSPIFMYAPEF	TXNIP	356	Q9H3M7
DVPETNYLFMGDFVD	PPP4C	71	P60510
PAVEFSFMEDDQAYP	TFR2	581	Q9UP52
LEESPFVPYDFMNSS	TNRC6A	1566	Q8NDV7
IDAPANYDVDLPFMF	TRPV5	541	Q9NQA5
AVSLAESEPMQYFDP	MXRA5	966	Q9NR99