Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HECT	ITCH HECW1 UBR5	6.01e-05	27	53	3	PF00632
Domain	HECTc	ITCH HECW1 UBR5	6.01e-05	27	53	3	SM00119
Domain	HECT_dom	ITCH HECW1 UBR5	6.01e-05	27	53	3	IPR000569
Domain	HECT	ITCH HECW1 UBR5	6.01e-05	27	53	3	PS50237
Domain	UBA	UBL7 USP5 CBL	8.30e-05	30	53	3	SM00165
Domain	UBA	UBL7 USP5 CBL	1.44e-04	36	53	3	PF00627
Domain	UBA	UBL7 USP5 CBL	2.63e-04	44	53	3	IPR015940
Domain	UBA	UBL7 USP5 CBL	3.20e-04	47	53	3	PS50030
Domain	UBA-like	UBL7 USP5 CBL	7.96e-04	64	53	3	IPR009060
Domain	-	MYCBP2 UBR5	1.76e-03	22	53	2	2.130.10.30
Domain	RCC1/BLIP-II	MYCBP2 UBR5	1.92e-03	23	53	2	IPR009091
Domain	Ion_trans_dom	TRPM4 KCNG3 ITPR2	4.16e-03	114	53	3	IPR005821
Domain	Ion_trans	TRPM4 KCNG3 ITPR2	4.16e-03	114	53	3	PF00520
Domain	WW	ITCH HECW1	7.87e-03	47	53	2	PF00397
Domain	WW	ITCH HECW1	8.20e-03	48	53	2	SM00456
Pubmed	The functional interactome landscape of the human histone deacetylase family.	TPR MYCBP2 UBR5 HDAC8 BEND3 PDIA3	5.78e-06	289	54	6	23752268
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	PHLDB1 ITCH MAP2 MYCBP2 RANBP3 TJP2 CBL FAM83H RUSC2	6.57e-06	861	54	9	36931259
Pubmed	UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.	UBR5 PDIA3	7.09e-06	3	54	2	32558906
Pubmed	Regulation of immune responses by E3 ubiquitin-protein ligases.	ITCH CBL	7.09e-06	3	54	2	11826757
Pubmed	Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.	ITCH CBL	7.09e-06	3	54	2	12226085
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TPR USP5 MYCBP2 UBR5 ZC3H13 TJP2 BEND3 RRP1	7.19e-06	653	54	8	22586326
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	ITCH HECW1 UBR5	8.97e-06	26	54	3	26949039
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	TPR ITCH MYCBP2 UBR5	9.57e-06	85	54	4	16051665
Pubmed	E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation.	RELB CBL	1.42e-05	4	54	2	33962939
Pubmed	Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling.	ITCH CBL	1.42e-05	4	54	2	19341794
Pubmed	Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.	CBL DNMT3A	1.42e-05	4	54	2	22905207
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	TRPM4 USP5 UBR5 PGAP4 PDIA3 SDR39U1 SNX13 FAM83H	1.44e-05	719	54	8	35337019
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	ITCH MYCBP2 UBR5 CBL	1.49e-05	95	54	4	29643511
Pubmed	Identification of Redox and Glucose-Dependent Txnip Protein Interactions.	TPR ITCH SAP30BP	1.70e-05	32	54	3	27437069
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	TPR MYCBP2 RANBP3 SAP30BP TJP2 BEND3 CBL	2.19e-05	549	54	7	38280479
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	TPR PHLDB1 MYCBP2 UBR5 TJP2 PDIA3 RRP1 FAM83H ITPR2	2.60e-05	1024	54	9	24711643
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	DDIT4 UBR5 RANBP3 TJP2 CBL	2.70e-05	226	54	5	31452512
Pubmed	Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons.	MAP2 PDIA3	3.54e-05	6	54	2	24825317
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	ZC3H13 SAP30BP BRD3 RRP1 DNMT3A	4.46e-05	251	54	5	31076518
Pubmed	Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.	TPR UBR5	4.94e-05	7	54	2	12594221
Pubmed	Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma.	ITCH MYCBP2	4.94e-05	7	54	2	36038253
Pubmed	The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel.	ITCH HECW1	6.59e-05	8	54	2	11244092
Pubmed	The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.	CELSR1 TJP2	8.46e-05	9	54	2	20704721
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	ITCH MAP2 MYCBP2 UBR5 RANBP3 ZC3H13 PDIA3 CLCC1 RRP1 ITPR2	8.50e-05	1487	54	10	33957083
Pubmed	ATG5 is required for B cell polarization and presentation of particulate antigens.	USP5 ZC3H13 SAP30BP PDIA3 RBFA RRP1 ITPR2	1.02e-04	701	54	7	30196744
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	ITCH FBN2 UBR5 TJP2	1.03e-04	156	54	4	29961565
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	TPR ITCH COL17A1 ZC3H13 SAP30BP TJP2 RRP1 FAM83H ITPR2	1.26e-04	1257	54	9	36526897
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TPR USP5 UCKL1 ZC3H13 TJP2 CBL	1.27e-04	503	54	6	16964243
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP5 ITCH SELENBP1 MYCBP2 UBR5 TJP2 BEND3 DPP3	1.51e-04	1005	54	8	19615732
Pubmed	Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina.	MAP2 DNMT3A	1.55e-04	12	54	2	21452232
Pubmed	Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo.	CELSR1 TJP2	1.55e-04	12	54	2	23406901
Pubmed	Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t.	RELB ITGAM	1.83e-04	13	54	2	21469133
Pubmed	Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.	CELSR1 FBN2 RELB	1.96e-04	72	54	3	25917818
Pubmed	Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains.	MAP2 ITGAM	2.13e-04	14	54	2	23751821
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	USP5 ITCH RANBP3 SAP30BP TJP2 ITGAM PDIA3 CLCC1 RRP1	2.35e-04	1367	54	9	32687490
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	TPR USP5 ITCH RANBP3 TJP2	2.41e-04	360	54	5	33111431
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	PHLDB1 MYCBP2 ZC3H13 TJP2 RRP1	2.44e-04	361	54	5	26167880
Pubmed	Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.	HECW1 CBL	2.45e-04	15	54	2	19144635
Pubmed	Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts.	TJP2 CBL	2.45e-04	15	54	2	16601135
Pubmed	Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.	USP5 HECW1 UBR5	2.57e-04	79	54	3	27325702
Pubmed	Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations.	ITCH HECW1	2.80e-04	16	54	2	25723849
Pubmed	A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.	ITCH UBR5	2.80e-04	16	54	2	22496338
Pubmed	Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells.	MAP2 ITGAM	2.80e-04	16	54	2	36768434
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 PHLDB1 CELSR1 MYCBP2 UCKL1 RELB FAM83H ITPR2	2.88e-04	1105	54	8	35748872
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	TPR PDIA3 CLCC1 RRP1 ITPR2	2.91e-04	375	54	5	32788342
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	USP5 ZC3H13 HDAC8 TJP2 BRD3	3.02e-04	378	54	5	34315543
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ITCH FBN2 UBR5 UCKL1 SAP30BP BEND3 BRD3 FAM83H	3.08e-04	1116	54	8	31753913
Pubmed	A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales.	FBN2 PCDH18	3.17e-04	17	54	2	22832960
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP5 ITCH	3.17e-04	17	54	2	23287719
Pubmed	Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.	MAP2 ITGAM	3.17e-04	17	54	2	23420014
Pubmed	Screening E3 substrates using a live phage display library.	MAP2 RRP1	3.17e-04	17	54	2	24124579
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP5 UBR5 TJP2 PGAP4 RELB PDIA3 CLCC1 RRP1 ITPR2	3.45e-04	1440	54	9	30833792
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	FBN2 ITGAM	3.56e-04	18	54	2	39040056
Pubmed	SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.	ITCH HECW1	3.98e-04	19	54	2	21572392
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHLDB1 HECW1 MYCBP2 UBR5	4.19e-04	225	54	4	12168954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PHLDB1 UBR5 BEND3 SNX13 RUSC2	4.23e-04	407	54	5	12693553
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TRPM4 PHLDB1 ITCH MAP2 MYCBP2 UCKL1 HDAC8 SDC3 CLCC1	4.40e-04	1489	54	9	28611215
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	ITCH UBR5	4.88e-04	21	54	2	37422473
Pubmed	Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.	ITCH HECW1	4.88e-04	21	54	2	37005481
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	USP5 CELSR1 FBN2 MYCBP2 PGAP4 PDIA3 CLCC1 ITPR2	5.01e-04	1201	54	8	35696571
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MYCBP2 UBR5 ZC3H13	5.14e-04	100	54	3	10048485
Pubmed	An unappreciated role for RNA surveillance.	MAP2 DPP3 SNX13	5.45e-04	102	54	3	14759258
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	ITCH MYCBP2 TJP2	5.45e-04	102	54	3	15778465
Pubmed	The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.	SAP30BP HDAC8 CLCC1	5.45e-04	102	54	3	37024974
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 SELENBP1 UBR5 BEND3 DPP3 RRP1	5.89e-04	670	54	6	22990118
Pubmed	The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis.	CELSR1 TJP2	6.39e-04	24	54	2	20223754
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	ITCH MAP2 RANBP3	6.79e-04	110	54	3	37219487
Pubmed	Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.	ITCH HECW1	6.94e-04	25	54	2	23873930
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	MYCBP2 UBR5	8.72e-04	28	54	2	35474067
Pubmed	Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung.	CELSR1 TJP2	8.72e-04	28	54	2	23195221
Pubmed	Atm deficiency in the DNA polymerase β null cerebellum results in cerebellar ataxia and Itpr1 reduction associated with alteration of cytosine methylation.	DNMT3A ITPR2	9.35e-04	29	54	2	32123907
Pubmed	Phosphorylated tau interactome in the human Alzheimer's disease brain.	USP5 MAP2 PDIA3	9.83e-04	125	54	3	32812023
Pubmed	A chromatin modulator sustains self-renewal and enables differentiation of postnatal neural stem and progenitor cells.	MAP2 ITGAM	1.00e-03	30	54	2	31065682
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	TPR MYCBP2 CLCC1 ITPR2	1.01e-03	285	54	4	32838362
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	PHLDB1 MAP2 SAP30BP TJP2 BRD3	1.04e-03	497	54	5	36774506
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	TRPM4 ITCH SAP30BP PDIA3 CLCC1	1.06e-03	499	54	5	22810586
Pubmed	Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.	HDAC8 ITPR2	1.07e-03	31	54	2	14684825
Pubmed	Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia.	FBN2 TJP2	1.07e-03	31	54	2	25762570
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TPR USP5 PHLDB1 ITCH MYCBP2 UBR5 PDIA3 FAM83H	1.09e-03	1353	54	8	29467282
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	MAP2 PCDH18	1.14e-03	32	54	2	19538749
Pubmed	Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.	UBL7 USP5	1.14e-03	32	54	2	19285159
Pubmed	Genetic mapping of the human and mouse phospholipase C genes.	MAP2 PDIA3	1.21e-03	33	54	2	8672127
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TPR RBMXL2 MYCBP2 ZC3H13 TJP2 BRD3	1.24e-03	774	54	6	15302935
Pubmed	Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.	TPR MAP2	1.29e-03	34	54	2	18539113
Pubmed	Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.	USP5 UBR5	1.29e-03	34	54	2	32842143
Pubmed	Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.	RBMXL2 UBR5	1.36e-03	35	54	2	19287380
Pubmed	O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development.	FBN2 HDAC8	1.44e-03	36	54	2	35167946
Pubmed	Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice.	FBN2 ITGAM	1.52e-03	37	54	2	34323105
Pubmed	A systems wide mass spectrometric based linear motif screen to identify dominant in-vivo interacting proteins for the ubiquitin ligase MDM2.	TPR PDIA3	1.52e-03	37	54	2	24583282
Interaction	TXNIP interactions	TPR DDIT4 USP5 ITCH MYCBP2 UBR5 SAP30BP	1.32e-06	212	53	7	int:TXNIP
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITCH HECW1	1.96e-03	36	33	2	823
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	DDIT4 SELENBP1 MYCBP2 MARCHF9 DNMT3A	4.85e-05	193	54	5	M6813
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL	DDIT4 SELENBP1 MYCBP2 MARCHF9 DNMT3A	5.22e-05	196	54	5	MM667
Coexpression	GSE15659_NONSUPPRESSIVE_TCELL_VS_ACTIVATED_TREG_DN	UBL7 TPR ZC3H13 SAP30BP SDC3	5.35e-05	197	54	5	M3567
Coexpression	GSE15659_RESTING_VS_ACTIVATED_TREG_DN	UBL7 UBR5 ZC3H13 SAP30BP SDC3	5.48e-05	198	54	5	M3563
Coexpression	GSE15659_CD45RA_NEG_CD4_TCELL_VS_ACTIVATED_TREG_DN	UBL7 TPR ZC3H13 SAP30BP SDC3	5.48e-05	198	54	5	M3557
Coexpression	GSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP	CELSR1 UBR5 ZC3H13 DPP3 RBFA	5.74e-05	200	54	5	M4827
Drug	valinomycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	TPR TRPM4 DDIT4 MAP2 RELB RUSC2	4.81e-06	184	54	6	5957_UP
Drug	Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; PC3; HT_HG-U133A	TPR USP5 FBN2 SDC3 CBL RUSC2	7.11e-06	197	54	6	5770_DN
Drug	Sulfadiazine [68-35-9]; Up 200; 16uM; MCF7; HT_HG-U133A	TPR RRAGD RANBP3 SDC3 CBL DNMT3A	7.32e-06	198	54	6	1688_UP
Drug	Dydrogesterone [152-62-5]; Up 200; 12.8uM; MCF7; HT_HG-U133A	TPR FBN2 HECW1 RELB SNX13 DNMT3A	7.32e-06	198	54	6	4836_UP
Drug	Amoxicillin [26787-78-0]; Up 200; 11uM; PC3; HT_HG-U133A	PHLDB1 FBN2 RANBP3 SNX13 DNMT3A RUSC2	7.53e-06	199	54	6	6285_UP
Drug	NSC-364372	TPR HECW1 NEIL2 RANBP3 HDAC8 TJP2 RELB RRP1	1.74e-05	484	54	8	CID000435143
Drug	Methyl benzethonium chloride [25155-18-4]; Up 200; 8.6uM; PC3; HT_HG-U133A	DDIT4 PHLDB1 ITCH HECW1 RELB	3.74e-05	159	54	5	4325_UP
Drug	17-AAG; Up 200; 1uM; PC3; HT_HG-U133A	TPR DDIT4 FBN2 COL17A1 ZC3H13	8.50e-05	189	54	5	4450_UP
Drug	Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; MCF7; HT_HG-U133A	DDIT4 HEMK1 RELB DNMT3A RUSC2	9.16e-05	192	54	5	3313_UP
Drug	ICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A	USP5 SELENBP1 RANBP3 RELB RUSC2	9.61e-05	194	54	5	6955_UP
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	PHLDB1 COL17A1 ITGAM SNX13 DNMT3A	9.61e-05	194	54	5	3308_UP
Drug	Trihexyphenidyl-D,L Hydrochloride [58947-95-8]; Up 200; 11.8uM; PC3; HT_HG-U133A	DDIT4 RRAGD PGAP4 CBL ADCYAP1	9.61e-05	194	54	5	4015_UP
Drug	SB 202190; Down 200; 1uM; PC3; HT_HG-U133A	TPR MAP2 RELB CBL SNX13	9.85e-05	195	54	5	7058_DN
Drug	Cinchonine [118-10-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	RANBP3 HEMK1 CBL SNX13 ITPR2	9.85e-05	195	54	5	4107_UP
Drug	clozapine; Up 200; 10uM; MCF7; HT_HG-U133A	PHLDB1 SDC3 RELB DNMT3A RUSC2	1.01e-04	196	54	5	5226_UP
Drug	(-)-Eseroline fumarate salt [104015-29-4]; Up 200; 12uM; MCF7; HT_HG-U133A	COL17A1 SDC3 CBL DNMT3A ITPR2	1.01e-04	196	54	5	3530_UP
Drug	Trimetazidine dihydrochloride [13171-25-0]; Down 200; 11.8uM; MCF7; HT_HG-U133A	USP5 PHLDB1 RRAGD RANBP3 HEMK1	1.03e-04	197	54	5	5479_DN
Drug	Delsoline [509-18-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	PHLDB1 RANBP3 SDC3 SNX13 ITPR2	1.03e-04	197	54	5	7212_UP
Drug	Bretylium tosylate [61-75-6]; Up 200; 9.6uM; PC3; HT_HG-U133A	PHLDB1 RRAGD HECW1 RELB SNX13	1.03e-04	197	54	5	6674_UP
Drug	Sertaconazole nitrate [99592-39-9]; Up 200; 8uM; MCF7; HT_HG-U133A	DDIT4 CBL ITGAM DNMT3A RUSC2	1.03e-04	197	54	5	6811_UP
Drug	ICI 182,780; Up 200; 1uM; MCF7; HT_HG-U133A	DDIT4 FBN2 SDC3 SNX13 RUSC2	1.03e-04	197	54	5	5202_UP
Drug	Bromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; PC3; HG-U133A	DDIT4 USP5 RANBP3 HEMK1 CLCC1	1.03e-04	197	54	5	1925_UP
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; HL60; HT_HG-U133A	ITCH RANBP3 CBL SNX13 ITPR2	1.06e-04	198	54	5	1332_DN
Drug	Nadolol [42200-33-9]; Up 200; 13uM; MCF7; HT_HG-U133A	ZC3H13 HEMK1 CBL ITGAM RUSC2	1.06e-04	198	54	5	3359_UP
Drug	Acemetacin [53164-05-9]; Down 200; 9.6uM; HL60; HT_HG-U133A	USP5 HEMK1 RELB CBL SNX13	1.06e-04	198	54	5	2411_DN
Drug	Cotinine (-) [486-56-6]; Down 200; 22.6uM; MCF7; HT_HG-U133A	TPR RRAGD RANBP3 SNX13 ITPR2	1.06e-04	198	54	5	5246_DN
Drug	Dirithromycin [62013-04-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A	TRPM4 PHLDB1 HECW1 ZC3H13 HEMK1	1.08e-04	199	54	5	7446_UP
Drug	Pepstatin A [26305-03-3]; Up 200; 5.8uM; PC3; HT_HG-U133A	ZC3H13 HEMK1 CBL SNX13 ITPR2	1.08e-04	199	54	5	4206_UP
Drug	Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A	TRPM4 USP5 RANBP3 SDC3 RUSC2	1.08e-04	199	54	5	2057_DN
Disease	asphyxia neonatorum (biomarker_via_orthology)	MAP2 PDIA3	4.73e-05	6	53	2	DOID:11088 (biomarker_via_orthology)
Disease	Amelogenesis Imperfecta	COL17A1 FAM83H	2.07e-04	12	53	2	C0002452
Disease	Juvenile Myelomonocytic Leukemia	CBL DNMT3A	5.31e-04	19	53	2	C0349639
Disease	age at onset, smoking initiation	MYCBP2 ITPR2	5.31e-04	19	53	2	EFO_0004847, EFO_0005670
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	BSND RELB DPP3 ITGAM	7.19e-04	225	53	4	EFO_0008317, EFO_0020947
Disease	free cholesterol measurement, intermediate density lipoprotein measurement	BSND RELB PDIA3	8.77e-04	104	53	3	EFO_0008591, EFO_0008595
Disease	Growth Disorders	CBL DNMT3A	1.92e-03	36	53	2	C0018273
Disease	free cholesterol measurement, low density lipoprotein cholesterol measurement	BSND RELB PDIA3	1.94e-03	137	53	3	EFO_0004611, EFO_0008591
Disease	cortical surface area measurement	CELSR1 ITCH FBN2 MAP2 MYCBP2 ZC3H13 BEND3 SNX13	2.60e-03	1345	53	8	EFO_0010736
Disease	left ventricular systolic function measurement	RSPH6A SNX13	2.85e-03	44	53	2	EFO_0008206
Disease	Acute Promyelocytic Leukemia	ITGAM DNMT3A	3.11e-03	46	53	2	C0023487

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFGEAAGDRGPYGTD	COL17A1	1326	Q9UMD9
DGREYPDAQGFAADV	BRD3	366	Q15059
KAGDDEPEYEDGRGF	DNMT3A	276	Q9Y6K1
FQGGDDGDGDFYIEP	CELSR1	931	Q9NYQ6
VFYGGPLGDTEDREA	DNHD1	4321	Q96M86
YAPDTEELEAERGGG	RBFA	316	Q8N0V3
SPEGGEDSDREDGNY	RANBP3	101	Q9H6Z4
GPDLLDDGFAYDPTA	RELB	481	Q01201
LFYPFGDDGDEGTLS	ITPR2	2246	Q14571
GDSEAGDSDYDLGRD	PCDH18	876	Q9HCL0
FYSADEPGVLGRDEA	KCNG3	126	Q8TAE7
PRSEDYDAGGSQDDD	KIAA1107	751	Q9UPP5
EDLFPGHRYDGGLDS	LRCH4	286	O75427
DAGSEGDPPRDDCYD	BEND3	486	Q5T5X7
GEDDSEYLERDAPAG	NEIL2	111	Q969S2
GDSGPLAYAAAGELE	LGR6	846	Q9HBX8
RSYEDPAALDGGEEG	HEMK1	256	Q9Y5R4
GEEGLDYSGPSREFF	HECW1	1286	Q76N89
YLEAEGGLGDPGDFS	ARNTL2	616	Q8WYA1
ESYRDPFGSRGEFEG	DPP3	316	Q9NY33
NRYEGTEDDYGDDPS	PGAP4	166	Q9BRR3
GDGDEEEYYGSEPRA	MARCHF9	51	Q86YJ5
EAYGEDGNPLPDFDG	ADCYAP1	41	P18509
FPGEEGLDYGGVARE	ITCH	581	Q96J02
EEEDLYYGLPDGAGD	BSND	291	Q8WZ55
NSGFGPEEDTAYLDG	DDIT4	61	Q9NX09
GAEGAPSPNYDDDDD	CBL	446	P22681
LTAEYDEDSPGGDFD	SDR39U1	116	Q9NRG7
GDDDHPDSIEYGLGY	HDAC8	86	Q9BY41
GGFLAPEYREEGAAV	FBN2	56	P35556
AEAYEDDVLAPGGRA	FAM83H	606	Q6ZRV2
PDDELDDLYSGSGSG	SDC3	71	O75056
VGLADYGDGPDSSDA	RRAGD	26	Q9NQL2
DRDGGCREDFEDYPA	MEIS3P1	76	A6NDR6
EPGLGDLYDDSIGDS	RUSC2	111	Q8N2Y8
EEGGAGRDSYEENPD	RSPH6A	511	Q9H0K4
DPSFRGSDDGDGESF	SNX13	521	Q9Y5W8
FRDGEEAGAYDGPRT	PDIA3	106	P30101
RDGFNPADVEAGLYG	SELENBP1	211	Q13228
ARCDAEAGRGDDYDP	MYCBP2	4556	O75592
GDDRDSGGPVLQFDY	RRP1	286	P56182
GAPGEEDNRGAVYLF	ITGAM	541	P11215
GPDDDGGYTADFDLR	RBMXL2	126	O75526
DYRPDGGAGDADFHY	CLCC1	386	Q96S66
DGEGGAYTDNELDEP	TJP2	926	Q9UDY2
YEADDAEGGDGTDPG	TPR	2001	P12270
PGGFLFEGLSDDEDD	UBL7	221	Q96S82
GPGDVLTFYDGDDLT	SEZ6	641	Q53EL9
CAEYSRADGGPEAGE	PHLDB1	621	Q86UU1
YGEDDFSRLGGDEDG	SAP30BP	46	Q9UHR5
NGFPYREDEEGAFGE	MAP2	46	P11137
GDRYFGTDAVPDGSD	UCKL1	526	Q9NWZ5
EPKGSLGFYGNEDED	USP5	626	P45974
PTDAYGELDFTGAGR	TRPM4	71	Q8TD43
GAGEGYEPISDDELD	ZC3H13	1456	Q5T200
GDDGDDTASESYLPG	UBR5	231	O95071