Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Dynein_HC_stalk	DNHD1 DNAH8	1.02e-03	14	64	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH8	1.02e-03	14	64	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH8	1.02e-03	14	64	2	PF08393
Domain	MT	DNHD1 DNAH8	1.02e-03	14	64	2	PF12777
Domain	TPR_repeat	TRANK1 TRAPPC12 CEP70 AIPL1	1.12e-03	133	64	4	IPR019734
Domain	DHC_fam	DNHD1 DNAH8	1.18e-03	15	64	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH8	1.18e-03	15	64	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH8	1.18e-03	15	64	2	PF03028
Domain	TPR-contain_dom	TRANK1 TRAPPC12 CEP70 AIPL1	1.75e-03	150	64	4	IPR013026
Domain	TPR_REGION	TRANK1 TRAPPC12 CEP70 AIPL1	2.47e-03	165	64	4	PS50293
Domain	TPR	TRANK1 TRAPPC12 CEP70 AIPL1	2.47e-03	165	64	4	PS50005
Domain	Cupredoxin	PADI4 HEPH	2.55e-03	22	64	2	IPR008972
Pubmed	sFRP2 Supersedes VEGF as an Age-related Driver of Angiogenesis in Melanoma, Affecting Response to Anti-VEGF Therapy in Older Patients.	SFRP2 VEGFA	3.66e-06	2	67	2	33097493
Pubmed	ADAMTS12 promotes oxaliplatin chemoresistance and angiogenesis in gastric cancer through VEGF upregulation.	ADAMTS12 VEGFA	3.66e-06	2	67	2	37619822
Pubmed	Inhibition of Hippo Signaling Improves Skin Lesions in a Rosacea-Like Mouse Model.	WWTR1 VEGFA	1.10e-05	3	67	2	33477764
Pubmed	circCCT3 Modulates Vascular Endothelial Growth Factor A and Wnt Signaling to Enhance Colorectal Cancer Metastasis Through Sponging miR-613.	CCT3 VEGFA	1.10e-05	3	67	2	31859543
Pubmed	VEGF-neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin.	WWTR1 VEGFA	1.10e-05	3	67	2	29717062
Pubmed	High VEGF Concentrations Accelerate Human Trabecular Meshwork Fibrosis in a TAZ-Dependent Manner.	WWTR1 VEGFA	1.10e-05	3	67	2	37298577
Pubmed	YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.	WWTR1 VEGFA	2.19e-05	4	67	2	28867486
Pubmed	Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response.	MGAT5 VEGFA	2.19e-05	4	67	2	20713592
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	CCT3 EIF4G1 TMEM214 CCDC168	9.61e-05	123	67	4	26912792
Pubmed	Nuclear membrane proteins with potential disease links found by subtractive proteomics.	SYNE1 TMEM209	1.63e-04	10	67	2	12958361
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TRAPPC12 ARHGAP26 ARID5B MED1 NRROS RFX1 CDY1	2.27e-04	638	67	7	31182584
Pubmed	The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts.	LRRN3 LRRN2	2.38e-04	12	67	2	15893969
Pubmed	Tbx18 regulates development of the epicardium and coronary vessels.	SFRP2 VEGFA	3.28e-04	14	67	2	24016759
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNHD1 CCT3 SYNE1 DNAH8	4.76e-04	187	67	4	26460568
Pubmed	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.	ADAMTS12 DNHD1 LRRN3 SFRP2 LRRN2 HEPACAM2 NRROS HEPH	5.99e-04	985	67	8	12975309
Pubmed	Genome-wide association studies identify four ER negative-specific breast cancer risk loci.	PIK3C2B LRRN2	7.50e-04	21	67	2	23535733
Pubmed	HIV-1 Tat promotes Kaposi's sarcoma-associated herpesvirus (KSHV) vIL-6-induced angiogenesis and tumorigenesis by regulating PI3K/PTEN/AKT/GSK-3β signaling pathway.	PIK3C2B VEGFA	9.01e-04	23	67	2	23301033
Pubmed	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	MGAT5 HAAO	9.01e-04	23	67	2	20468071
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SYNE1 DNAH8	1.24e-03	27	67	2	18649358
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE4A PIK3C2B	1.24e-03	27	67	2	11156964
Pubmed	Diverse Functions of Retinoic Acid in Brain Vascular Development.	SFRP2 VEGFA	1.34e-03	28	67	2	27445154
Pubmed	Genetics of rheumatoid arthritis contributes to biology and drug discovery.	PADI4 ARID5B MED1	1.34e-03	112	67	3	24390342
Pubmed	Viral immune modulators perturb the human molecular network by common and unique strategies.	CCT3 SYNE1 SMYD3	1.48e-03	116	67	3	22810585
Pubmed	Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling.	SFRP2 VEGFA	1.54e-03	30	67	2	23349620
Pubmed	Network organization of the human autophagy system.	STRADB CCT3 TRAPPC12 UVRAG XPOT	1.56e-03	437	67	5	20562859
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	CENPI LSM4 DCLRE1A MED1 RFX1	1.83e-03	453	67	5	29656893
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	PADI4 GSPT2 IQCA1 CENPI ZFHX2 LRRN2	1.90e-03	674	67	6	37196079
Coexpression	GSE11057_NAIVE_VS_CENT_MEMORY_CD4_TCELL_UP	ADAMTS12 DNHD1 PADI4 LRRN3 STK26 CEP70 GAL3ST4	4.56e-07	196	63	7	M3106
Coexpression	GSE21379_TFH_VS_NON_TFH_CD4_TCELL_UP	TRAPPC12 UNC5CL SYNE1 SIMC1 HEPACAM2 DNAH8 VEGFA	5.22e-07	200	63	7	M7500
Coexpression	GSE17186_BLOOD_VS_CORD_BLOOD_CD21HIGH_TRANSITIONAL_BCELL_UP	KIFAP3 ARHGAP26 CENPI ALS2 DCLRE1A NUTF2	8.66e-06	200	63	6	M7185
Disease	Bipolar Disorder	PDE4A TRANK1 MCHR1 SYNE1 DNAH8 VEGFA	6.38e-04	477	65	6	C0005586
Disease	kidney volume	PDILT VEGFA	7.15e-04	18	65	2	EFO_0600044
Disease	lymphocyte count, response to vaccine	ARHGAP26 PIWIL1	1.07e-03	22	65	2	EFO_0004587, EFO_0004645
Disease	mental development measurement	WWTR1 EFR3A	1.39e-03	25	65	2	EFO_0008230
Disease	uromodulin measurement	MGAT5 PDILT	1.50e-03	26	65	2	EFO_0021778
Disease	hearing threshold measurement	LRRN2 UVRAG	1.74e-03	28	65	2	EFO_0007618
Disease	response to tenofovir, creatinine clearance measurement	TRAPPC12 ARHGAP26 OR5M3	1.96e-03	112	65	3	EFO_0007934, EFO_0009279
Disease	Drug-Induced Liver Disease	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C0860207
Disease	Drug-Induced Acute Liver Injury	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C3658290
Disease	Chemical and Drug Induced Liver Injury	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C4277682
Disease	Hepatitis, Drug-Induced	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C1262760
Disease	Hepatitis, Toxic	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C0019193
Disease	Chemically-Induced Liver Toxicity	GSTM4 CCT3 TMEM164 MED1 VEGFA	1.98e-03	404	65	5	C4279912
Disease	proteinuria (implicated_via_orthology)	MGAT5 VEGFA	2.00e-03	30	65	2	DOID:576 (implicated_via_orthology)
Disease	Drug habituation	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0013170
Disease	Substance-Related Disorders	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0236969
Disease	Drug abuse	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0013146
Disease	Drug Use Disorders	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0013222
Disease	Drug Dependence	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C1510472
Disease	Substance Dependence	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0038580
Disease	Substance Use Disorders	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0038586
Disease	Organic Mental Disorders, Substance-Induced	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C0029231
Disease	Prescription Drug Abuse	SYNE1 PIWIL1 DNAH8	2.11e-03	115	65	3	C4316881
Disease	Substance abuse problem	SYNE1 PIWIL1 DNAH8	2.17e-03	116	65	3	C0740858
Disease	creatinine measurement, chronic kidney disease	PDILT VEGFA	2.71e-03	35	65	2	EFO_0003884, EFO_0004518
Disease	osteoarthritis, hand	DNAH8 UVRAG	3.03e-03	37	65	2	EFO_1000789

Protein segments in the cluster

Peptide	Gene	Start	Entry
GIQNKTQIHPLMSQM	CDY1	196	Q9Y6F8
GQPMHIIIGNMFKLE	AIPL1	56	Q9NZN9
LMHQEQLKVMFIGGP	HAAO	26	P46952
NFHLNKMMGNGVLLS	ALS2	1201	Q96Q42
HAIMPKLQQLMAAAL	DNHD1	931	Q96M86
MMLHAVFKVARQLQP	IQCA1	616	Q86XH1
PQHMDKIVPSLLFNM	EFR3A	191	Q14156
ILTIMNMVTGLFHNP	ADAMTS12	271	P58397
AFFPNMVNMLVLGKH	PADI4	581	Q9UM07
TLSMLHLQKNSIGPM	NLRC3	751	Q7RTR2
HLQKNSIGPMGAQRM	NLRC3	756	Q7RTR2
GMMLLHFTIQQRTQP	MGAT5	26	Q09328
APTLFMFMLNGKQEH	KY	376	Q8NBH2
FANMLHLKELGLNNM	LRRN2	281	O75325
FKGQQLVMMPNKHNV	GSPT2	456	Q8IYD1
LGLSDHPQMKIFLFM	OR5A2	16	Q8NGI9
PMSQITGLKKLMHSN	PDE4A	331	P27815
IKMGHLNSMNIFLRQ	DNAH8	4246	Q96JB1
KIQHLRLQGQMPALM	DDX28	421	Q9NUL7
IMGFHQMFLLKNIND	NUTF2	96	P61970
IGMMVLIKVSPQLNN	OR5M3	41	Q8NGP4
HMRFNLKEVLQVMPS	GAL3ST4	136	Q96RP7
KMLSLFHSVFNPMLN	OR2A2	271	Q6IF42
NNKLFIMVMHIRGLQ	PIK3C2B	1516	O00750
SINVLLMMHGLKPLS	CEP70	31	Q8NHQ1
GLTPKTIMHLMINNN	DNM1P34	56	Q6PK57
SILNKLTPQMFQQLM	EIF4G1	766	Q04637
FLLGMPFMIHQLMGN	MCHR1	161	Q99705
MLPLSLLKTAQNHPM	LSM4	1	Q9Y4Z0
HKFTMMPPNASLLIN	HEPACAM2	96	A8MVW5
SSLVHLLPMMQINFK	DCLRE1A	926	Q6PJP8
LLPMMQINFKGLQSH	DCLRE1A	931	Q6PJP8
LTMKIQNHPIPQMLN	CCDC168	6096	Q8NDH2
QAKMGMQPHLQALLS	CENPI	226	Q92674
FRNMVNVKMPFHLTL	POLI	416	Q9UNA4
VLPSMKMGQIINIFH	C18orf63	201	Q68DL7
PLLMKMIRNISQHDG	KIFAP3	481	Q92845
AGNTKNHPMLMNLLK	MED1	636	Q15648
PMLQVLSLRNMGLHS	NRROS	511	Q86YC3
MLNQTRFLMVLFHNP	PDILT	56	Q8N807
LIQNLFKVTPAMGMQ	PIWIL1	511	Q96J94
LPNLKNFMEHGLMVR	UVRAG	451	Q9P2Y5
QNMRLPNLLGHETMK	SFRP2	56	Q96HF1
NGQHKLNMMLSKGEL	SYNE1	3116	Q8NF91
SNMLHLKELGINNMP	LRRN3	281	Q9H3W5
HMAMRGQPFSQKQRL	RFX1	526	P22670
DMHPMRVLFLIPKNN	STK26	221	Q9P289
LPTMMQHFSQFLGKR	GSTM4	131	Q03013
QLQGMRKGAAMLFPH	HEPH	666	Q9BQS7
LPEKNRQMLQLLMNH	ARHGAP26	496	Q9UNA1
EAYMLLMKIQQLHPA	SIMC1	526	Q8NDZ2
NLHNMISGLPAKMRI	SLC3A1	606	Q07837
MMGHRPVLVLSQNTK	CCT3	1	P49368
VGKLQLHQGMFPQAM	SMYD3	376	Q9H7B4
LHQGMFPQAMKNLRL	SMYD3	381	Q9H7B4
MQPLAFHSLVMQRGI	ARID5B	1116	Q14865
EKHMQNVLMLHQGLP	ZFHX2	591	Q9C0A1
VLHLMNKMNLPTPFG	RNPC3	186	Q96LT9
LQGKIMVLMNSAFLH	TRAPPC12	616	Q8WVT3
FKLQMHMLNGALLAL	TMEM164	146	Q5U3C3
LLLMHPNLTKGFGMI	TMEM214	301	Q6NUQ4
PTQGQTMVRQLMHKL	UNC5CL	86	Q8IV45
NLPKGRNNMFHTLLM	TMEM209	516	Q96SK2
QVSPFLQQMFMPLLH	XPOT	756	O43592
VPFQDMHRTQMLLQK	STRADB	266	Q9C0K7
MVKPLLHMLLNTTLN	ZBED1	421	O96006
NGNTLMHILFQKGML	TRANK1	546	O15050
NITMQIMRIKPHQGQ	VEGFA	101	P15692
RKAMNQPLNHMNLHP	WWTR1	156	Q9GZV5
LPMNFKDNHGIALMA	ART3	86	Q13508