Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction1-phosphatidylinositol-3-phosphate 5-kinase activity

PIKFYVE PIP5K1A

8.83e-0531092GO:0000285
GeneOntologyMolecularFunction1-phosphatidylinositol-5-kinase activity

PIKFYVE PIP5K1A

8.83e-0531092GO:0052810
GeneOntologyMolecularFunctionribonucleoprotein complex binding

AGO2 RHBDD2 EEF2 XPO5 STAU2 WDR12 SNRPA

1.38e-042061097GO:0043021
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

PIKFYVE FIG4

4.37e-0461092GO:0043813
GeneOntologyMolecularFunctionRISC complex binding

AGO2 XPO5

4.37e-0461092GO:1905172
GeneOntologyCellularComponentFACT complex

MMS22L SSRP1

1.61e-0441092GO:0035101
GeneOntologyCellularComponentendoplasmic reticulum tubular network membrane

ATL1 ATL2

2.67e-0451092GO:0098826
GeneOntologyCellularComponentGolgi membrane

GBF1 MGAT4A ARFGEF2 ARFGEF1 RHBDD2 SMPD4 ATL1 PIKFYVE CSGALNACT2 FIG4 VPS13B PLCE1

3.81e-0472110912GO:0000139
GeneOntologyCellularComponentcell projection membrane

TCTN3 PDE9A HCN1 ATP8B1 PTCH1 KCNC1 SLC39A6 PIP5K1A DMD

4.29e-044311099GO:0031253
GeneOntologyCellularComponentpole plasm

AGO2 TDRD7 DDX3Y

4.57e-04291093GO:0045495
GeneOntologyCellularComponentgerm plasm

AGO2 TDRD7 DDX3Y

4.57e-04291093GO:0060293
GeneOntologyCellularComponentP granule

AGO2 TDRD7 DDX3Y

4.57e-04291093GO:0043186
GeneOntologyCellularComponentlate endosome

VPS8 PXK EXOC8 PIKFYVE SNX14 FIG4 ASTN2 RMC1

4.81e-043481098GO:0005770
GeneOntologyCellularComponentGolgi apparatus subcompartment

GBF1 MGAT4A ARFGEF2 ARFGEF1 SMPD4 ATP8B1 ATL1 CSGALNACT2 VPS13B

5.22e-044431099GO:0098791
GeneOntologyCellularComponentcell leading edge

GBF1 PDE9A HCN1 EXOC8 KCNC1 SLC39A6 PIP5K1A DMD PLCE1

1.23e-035001099GO:0031252
DomainSec7_N

GBF1 ARFGEF2 ARFGEF1

7.28e-0741073IPR032691
DomainSec7_N

GBF1 ARFGEF2 ARFGEF1

7.28e-0741073PF12783
Domain-

COL6A2 COL6A3 COL6A5 SEC24D MDN1

6.61e-057410753.40.50.410
Domain-

GBF1 ARFGEF2 ARFGEF1

7.91e-051510731.10.1000.11
DomainSec7

GBF1 ARFGEF2 ARFGEF1

7.91e-05151073PF01369
DomainSec7_alpha_orthog

GBF1 ARFGEF2 ARFGEF1

7.91e-05151073IPR023394
DomainSEC7

GBF1 ARFGEF2 ARFGEF1

9.70e-05161073PS50190
DomainSec7

GBF1 ARFGEF2 ARFGEF1

9.70e-05161073SM00222
DomainSec7_dom

GBF1 ARFGEF2 ARFGEF1

9.70e-05161073IPR000904
DomainSHR-BD

VPS13A VPS13B

1.94e-0441072IPR009543
DomainDCB_dom

ARFGEF2 ARFGEF1

1.94e-0441072IPR032629
DomainSec7_C

ARFGEF2 ARFGEF1

1.94e-0441072IPR015403
DomainDUF1981

ARFGEF2 ARFGEF1

1.94e-0441072PF09324
DomainVPS13_C

VPS13A VPS13B

1.94e-0441072PF16909
DomainVPS13_C

VPS13A VPS13B

1.94e-0441072IPR031645
DomainDCB

ARFGEF2 ARFGEF1

1.94e-0441072PF16213
DomainSHR-BD

VPS13A VPS13B

1.94e-0441072PF06650
DomainVWF_A

COL6A2 COL6A3 COL6A5 SEC24D MDN1

2.62e-04991075IPR002035
DomainAutophagy-rel_C

VPS13A VPS13B

3.22e-0451072IPR015412
DomainATG_C

VPS13A VPS13B

3.22e-0451072PF09333
DomainPIPKc

PIKFYVE PIP5K1A

8.90e-0481072SM00330
Domain-

PIKFYVE PIP5K1A

8.90e-04810723.30.800.10
DomainChorein_N

VPS13A VPS13B

8.90e-0481072PF12624
DomainPIP5K

PIKFYVE PIP5K1A

8.90e-0481072PF01504
DomainPIPK

PIKFYVE PIP5K1A

8.90e-0481072PS51455
DomainPInositol-4-P-5-kinase_N

PIKFYVE PIP5K1A

8.90e-0481072IPR027484
DomainPInositol-4-P-5-kinase_C

PIKFYVE PIP5K1A

8.90e-0481072IPR027483
DomainVPS13_N

VPS13A VPS13B

8.90e-0481072IPR026854
Domain-

PIKFYVE PIP5K1A

8.90e-04810723.30.810.10
DomainPInositol-4-P-5-kinase_core

PIKFYVE PIP5K1A

8.90e-0481072IPR002498
DomainPtc/Disp

PTCH1 PTCHD4

1.14e-0391072IPR003392
DomainPatched

PTCH1 PTCHD4

1.14e-0391072PF02460
DomainSERPIN

SERPINA6 SERPINA2 SERPINA5

1.23e-03371073PS00284
DomainSERPIN

SERPINA6 SERPINA2 SERPINA5

1.23e-03371073SM00093
DomainVWFA

COL6A2 COL6A3 COL6A5 MDN1

1.26e-03821074PS50234
DomainSerpin

SERPINA6 SERPINA2 SERPINA5

1.33e-03381073PF00079
DomainVWA

COL6A2 COL6A3 COL6A5 MDN1

1.38e-03841074SM00327
DomainGBP_C

ATL1 ATL2

1.42e-03101072PF02841
DomainSerpin_fam

SERPINA6 SERPINA2 SERPINA5

1.44e-03391073IPR000215
DomainWD40_repeat_dom

GRWD1 VPS8 ARHGEF10L DMXL1 ARHGEF10 WDR12 RMC1

1.61e-032971077IPR017986
DomainG_GB1_RHD3_dom

ATL1 ATL2

1.73e-03111072IPR030386
DomainGuanylate-bd_N

ATL1 ATL2

1.73e-03111072IPR015894
DomainGuanylate-bd_C

ATL1 ATL2

1.73e-03111072IPR003191
DomainGBP

ATL1 ATL2

1.73e-03111072PF02263
DomainG_GB1_RHD3

ATL1 ATL2

1.73e-03111072PS51715
DomainPX

PXK SNX14 SH3PXD2A

2.04e-03441073SM00312
DomainCOS

FSD1L TRIM36

2.07e-03121072PS51262
DomainCOS_domain

FSD1L TRIM36

2.07e-03121072IPR017903
DomainSSD

PTCH1 PTCHD4

2.43e-03131072IPR000731
DomainSSD

PTCH1 PTCHD4

2.43e-03131072PS50156
DomainPX

PXK SNX14 SH3PXD2A

2.78e-03491073PF00787
DomainPX

PXK SNX14 SH3PXD2A

2.95e-03501073PS50195
Domain-

GRWD1 VPS8 ARHGEF10L DMXL1 ARHGEF10 WDR12 RMC1

3.06e-0333310772.130.10.10
Domain-

PXK SNX14 SH3PXD2A

3.12e-035110733.30.1520.10
DomainWD40/YVTN_repeat-like_dom

GRWD1 VPS8 ARHGEF10L DMXL1 ARHGEF10 WDR12 RMC1

3.16e-033351077IPR015943
DomainBbox_C

TRIM66 FSD1L

3.25e-03151072IPR003649
DomainBBC

TRIM66 FSD1L

3.25e-03151072SM00502
DomainPhox

PXK SNX14 SH3PXD2A

3.30e-03521073IPR001683
DomainVWA

COL6A2 COL6A3 COL6A5

4.07e-03561073PF00092
DomainDSRM

DROSHA STAU2

5.22e-03191072SM00358
PathwayWP_EXRNA_MECHANISM_OF_ACTION_AND_BIOGENESIS

AGO2 XPO5 DROSHA

2.64e-066733M39578
PathwayBIOCARTA_ARAP_PATHWAY

GBF1 ARFGEF2 ARFGEF1

8.60e-0517733M2482
PathwayWP_PHOSPHATIDYL_INOSITOL_PHOSPHATE_PATHWAY

PIKFYVE FIG4 PIP5K1A PLCE1

9.16e-0546734M48317
PathwayREACTOME_NCAM1_INTERACTIONS

COL6A2 COL6A3 COL6A5

1.43e-0420733MM15061
PathwayREACTOME_MICRORNA_MIRNA_BIOGENESIS

AGO2 XPO5 DROSHA

2.82e-0425733M712
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

GBF1 TBC1D5 VPS8 ARFGEF2 ARFGEF1 RHBDD2 POR ATL1 DMXL1 PIKFYVE SNX14 FIG4 VPS13A RMC1 SLC29A1 VPS13B

5.98e-125041101634432599
Pubmed

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

GBF1 ARFGEF2 ARFGEF1

3.08e-083110323386609
Pubmed

Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.

GBF1 ARFGEF2 ARFGEF1

3.08e-083110318003980
Pubmed

A linkage disequilibrium between genes at the serine protease inhibitor gene cluster on chromosome 14q32.1 is associated with Wegener's granulomatosis.

SERPINA6 SERPINA2 SERPINA5

1.23e-074110311161981
Pubmed

The expanded collagen VI family: new chains and new questions.

COL6A2 COL6A3 COL6A5

3.06e-075110323869615
Pubmed

Developmental regulation of biglycan expression in muscle and tendon.

COL6A2 COL6A3 DMD

6.11e-076110316810681
Pubmed

Three novel collagen VI chains with high homology to the alpha3 chain.

COL6A2 COL6A3 COL6A5

1.07e-067110318276594
Pubmed

Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI).

COL6A2 COL6A3 COL6A5

1.07e-067110318400749
Pubmed

Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.

AGO2 XPO5 DROSHA

1.70e-068110320211803
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

TCTN3 MASP1 SPATA6 HCN1 TBC1D5 ARHGAP26 ANO5 ATP8B1 MICU1 TRIM36 VPS13B GNPAT

1.91e-066861101229987050
Pubmed

Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.

AGO2 XPO5 DROSHA

3.63e-0610110320721975
Pubmed

The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis.

COL6A2 COL6A3 FREM2

3.63e-0610110315345741
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TRAF3IP2 TCTN3 EDC3 PDE9A APMAP ARHGAP26 RHBDD2 SSRP1 EXOC8 MICU1 METTL9 XPO5 KLHL7 POMP SH3PXD2A ATL2

4.16e-0613211101627173435
Pubmed

Defining the membrane proteome of NK cells.

EDC3 GBF1 AGO2 APMAP ARFGEF2 POR EXOC8 EEF2 MDN1 CSGALNACT2 STAU2 DDX3Y ATL2 SLC29A1 GNPAT

4.25e-0611681101519946888
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

GBF1 APMAP TBC1D5 RHBDD2 POR SMPD4 NCBP1 ATL1 EXOC8 EEF2 XPO5 SLC39A6 ATL2 SLC29A1 GNPAT

6.05e-0612031101529180619
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

TRAF3IP2 COL6A2 TBC1D5 RHBDD2 EXOC8 LIG3 FREM2 DROSHA PIP5K1A GNPAT PLCE1

7.15e-066501101138777146
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

MMS22L GBF1 GRWD1 ARFGEF1 SMPD4 NCBP1 SSRP1 EXOC8 EEF2 XPO5 VPS13A

7.90e-066571101136180527
Pubmed

Hijacking components of the cellular secretory pathway for replication of poliovirus RNA.

GBF1 ARFGEF1

9.91e-062110217079330
Pubmed

The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.

PIKFYVE FIG4

9.91e-062110226405034
Pubmed

Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.

ARFGEF2 ARFGEF1

9.91e-062110223918382
Pubmed

FLT3-ITD induces ara-C resistance in myeloid leukemic cells through the repression of the ENT1 expression.

FLT3 SLC29A1

9.91e-062110219853583
Pubmed

Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma.

ARFGEF2 ARFGEF1

9.91e-062110217360629
Pubmed

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.

ARFGEF2 ARFGEF1

9.91e-062110210716990
Pubmed

Membrane association of the Arabidopsis ARF exchange factor GNOM involves interaction of conserved domains.

ARFGEF2 ARFGEF1

9.91e-062110218203920
Pubmed

GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice.

ARHGAP26 DMD

9.91e-062110226301073
Pubmed

Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.

ARFGEF2 ARFGEF1

9.91e-062110218417613
Pubmed

FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia.

FLT3 SLC29A1

9.91e-062110227391351
Pubmed

Roles for a lipid phosphatase in the activation of its opposing lipid kinase.

PIKFYVE FIG4

9.91e-062110232583743
Pubmed

Reconstitution of human atlastin fusion activity reveals autoinhibition by the C terminus.

ATL1 ATL2

9.91e-062110234817557
Pubmed

Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

9.91e-062110210212200
Pubmed

Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs.

AGO2 DROSHA STAU2

1.67e-0516110320102707
Pubmed

Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.

COL6A2 COL6A3 FREM2

1.67e-0516110316880404
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

GRWD1 MTERF3 POR SMPD4 SSRP1 DMXL1 MICU1 MDN1 ARHGEF10 GLS STAU2 VPS13A SLC39A6 PIP5K1A WDR12 VPS13B

1.81e-0514871101633957083
Pubmed

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

AGO2 XPO5 DROSHA

2.43e-0518110319047128
Pubmed

Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation.

TCTN3 ANO5 PTCH1

2.43e-0518110334893605
Pubmed

A crucial role for Arf6 in the response of commissural axons to Slit.

GBF1 ARFGEF2 ARFGEF1

2.87e-0519110330674481
Pubmed

Mosaicism for dominant collagen 6 mutations as a cause for intrafamilial phenotypic variability.

COL6A2 COL6A3

2.97e-053110225204870
Pubmed

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity.

ARFGEF2 ARFGEF1

2.97e-053110219332778
Pubmed

Specific functions of BIG1 and BIG2 in endomembrane organization.

ARFGEF2 ARFGEF1

2.97e-053110220360857
Pubmed

VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

PIKFYVE FIG4

2.97e-053110219037259
Pubmed

Association between Genetic Polymorphisms in microRNA Machinery Genes and Risk of Papillary Thyroid Carcinoma.

XPO5 DROSHA

2.97e-053110231250375
Pubmed

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

CYP2A13 POR

2.97e-053110220840855
Pubmed

Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

PIKFYVE FIG4

2.97e-053110222028665
Pubmed

Amino acid sequence of the triple-helical domain of human collagen type VI.

COL6A2 COL6A3

2.97e-05311023198591
Pubmed

AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.

ARFGEF2 ARFGEF1

2.97e-053110216866877
Pubmed

Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis.

XPO5 DROSHA

2.97e-053110226976605
Pubmed

Cloning and sequence analysis of cDNAs encoding the alpha 1, alpha 2 and alpha 3 chains of mouse collagen VI.

COL6A2 COL6A3

2.97e-05311028489506
Pubmed

Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance.

COL6A2 COL6A3

2.97e-053110218366090
Pubmed

Expression of the microRNA regulators Drosha, Dicer and Ago2 in non-small cell lung carcinomas.

AGO2 DROSHA

2.97e-053110226227789
Pubmed

Collagen VI related muscle disorders.

COL6A2 COL6A3

2.97e-053110216141002
Pubmed

Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes.

ATL1 ATL2

2.97e-053110225773277
Pubmed

Collagen VI-Related Dystrophies

COL6A2 COL6A3

2.97e-053110220301676
Pubmed

Characterization of three constituent chains of collagen type VI by peptide sequences and cDNA clones.

COL6A2 COL6A3

2.97e-05311023665927
Pubmed

Expression of the ribonucleases Drosha, Dicer, and Ago2 in colorectal carcinomas.

AGO2 DROSHA

2.97e-053110221769619
Pubmed

Involvement of BIG1 and BIG2 in regulating VEGF expression and angiogenesis.

ARFGEF2 ARFGEF1

2.97e-053110231199673
Pubmed

Collagen type VI myopathies.

COL6A2 COL6A3

2.97e-053110224443028
Pubmed

Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy.

COL6A2 COL6A3

2.97e-053110215563506
Pubmed

Enhancement of β-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals.

ARFGEF2 ARFGEF1

2.97e-053110227162341
Pubmed

PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.

PIKFYVE FIG4

2.97e-053110219840946
Pubmed

Expression of type VI collagen in the developing mouse heart.

COL6A2 COL6A3

2.97e-05311029520112
Pubmed

ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.

PIKFYVE FIG4

2.97e-053110218950639
Pubmed

Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen.

COL6A2 COL6A3

2.97e-05311023348212
Pubmed

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

PIKFYVE FIG4

2.97e-053110223047693
Pubmed

MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production.

AGO2 DROSHA

2.97e-053110224938790
Pubmed

Collagen VI protects against neuronal apoptosis elicited by ultraviolet irradiation via an Akt/phosphatidylinositol 3-kinase signaling pathway.

COL6A2 COL6A3

2.97e-053110221459131
Pubmed

Extracellular Matrix Disorganization and Sarcolemmal Alterations in COL6-Related Myopathy Patients with New Variants of COL6 Genes.

COL6A2 COL6A3

2.97e-053110236982625
Pubmed

Immunohistochemical analysis of the endoribonucleases Drosha, Dicer and Ago2 in smooth muscle tumours of soft tissues.

AGO2 DROSHA

2.97e-053110222394132
Pubmed

Complexity in regulation of microRNA machinery components in invasive breast carcinoma.

AGO2 DROSHA

2.97e-053110224574065
Pubmed

Novel collagen VI mutations identified in Chinese patients with Ullrich congenital muscular dystrophy.

COL6A2 COL6A3

2.97e-053110224801232
Pubmed

Hepatic cytochrome P450 deficiency in mouse models for intrahepatic cholestasis predispose to bile salt-induced cholestasis.

POR ATP8B1

2.97e-053110225068656
Pubmed

Lipid kinase PIP5K1A regulates let-7 microRNA biogenesis through interacting with nuclear export protein XPO5.

XPO5 PIP5K1A

2.97e-053110237655623
Pubmed

Expression of collagen alpha 1(VI), alpha 2(VI), and alpha 3(VI) chains in the pregnant mouse uterus.

COL6A2 COL6A3

2.97e-05311027780011
Pubmed

Inducing cell proliferation inhibition and apoptosis via silencing Dicer, Drosha, and Exportin 5 in urothelial carcinoma of the bladder.

XPO5 DROSHA

2.97e-053110222766726
Pubmed

A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

ARFGEF2 ARFGEF1

2.97e-053110218832381
Pubmed

Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.

PIKFYVE FIG4

2.97e-053110217556371
Pubmed

Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures.

COL6A2 COL6A3

2.97e-05311028782832
Pubmed

Collagen VI involvement in Ullrich syndrome: a clinical, genetic, and immunohistochemical study.

COL6A2 COL6A3

2.97e-053110212011280
Pubmed

The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping.

XPO5 DROSHA

2.97e-053110234855193
Pubmed

Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.

ATL1 ATL2

2.97e-053110227669642
Pubmed

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

TBC1D5 VPS8 SMPD4 DMXL1 PIKFYVE FIG4 TRIM36

3.57e-05285110734369648
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

GBF1 GRWD1 NCBP1 SSRP1 FAF1 EEF2 MDN1 XPO5 WDR12 SNRPA

3.64e-056381101033239621
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

SSRP1 SRCAP LIG3 MDN1 PIP5K1A SMARCD1 WDR12 SNRPA

3.79e-05394110827248496
Pubmed

Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.

SERPINA6 SERPINA2 SERPINA5

3.93e-0521110315014966
Pubmed

Agrin has a pathological role in the progression of oral cancer.

COL6A2 SNX14 EEF2 GLS PIP5K1A DMD

4.02e-05197110629872149
Pubmed

Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members.

ARFGEF2 ARFGEF1

5.92e-054110211013081
Pubmed

Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506.

ARFGEF2 ARFGEF1

5.92e-054110212606707
Pubmed

Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).

ARFGEF2 ARFGEF1

5.92e-054110212571360
Pubmed

3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.

XPO5 DROSHA

5.92e-054110226147304
Pubmed

The Amyloid Precursor Protein Controls PIKfyve Function.

PIKFYVE FIG4

5.92e-054110226125944
Pubmed

Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.

ARFGEF2 ARFGEF1

5.92e-054110222084092
Pubmed

Phosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α.

PIKFYVE PIP5K1A

5.92e-054110226157143
Pubmed

Argonaute, Dicer, and Drosha are up-regulated along tumor progression in serous ovarian carcinoma.

AGO2 DROSHA

5.92e-054110222647351
Pubmed

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis.

AGO2 DROSHA

5.92e-054110220699384
Pubmed

Analysis of the human VPS13 gene family.

VPS13A VPS13B

5.92e-054110215498460
Pubmed

Deposition of collagen VI in the extracellular matrix during mouse embryogenesis correlates with expression of the alpha 3(VI) subunit gene.

COL6A2 COL6A3

5.92e-05411028806434
Pubmed

Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.

PTCH1 DMD

5.92e-054110228709001
Pubmed

An enhancer required for transcription of the Col6a1 gene in muscle connective tissue is induced by signals released from muscle cells.

COL6A2 COL6A3

5.92e-054110218761340
Pubmed

Fas-associated factor (FAF1) is required for the early cleavage-stages of mouse embryo.

ARFGEF2 FAF1

5.92e-054110218303090
Pubmed

Analysis of microRNA processing machinery gene (DROSHA, DICER1, RAN, and XPO5) variants association with end-stage renal disease.

XPO5 DROSHA

5.92e-054110232770606
Pubmed

Deficiency of tenascin-X causes a decrease in the level of expression of type VI collagen.

COL6A2 COL6A3

5.92e-054110215194424
InteractionEDNRB interactions

MMS22L VPS8 ARFGEF2 ARFGEF1 PXK

2.01e-06391085int:EDNRB
InteractionRHOF interactions

GBF1 GRWD1 TBC1D5 ARFGEF2 POR SSRP1 PIKFYVE LIG3 MDN1 XPO5 VPS13A SLC39A6 PIP5K1A SLC29A1 VPS13B

3.02e-0667310815int:RHOF
InteractionRAB9A interactions

TBC1D5 VPS8 ARFGEF2 ARFGEF1 POR SMPD4 ATL1 DMXL1 PIKFYVE SNX14 VPS13A SLC39A6 SLC29A1 VPS13B

3.58e-0659510814int:RAB9A
InteractionRAB7A interactions

TCTN3 GBF1 TBC1D5 VPS8 ARFGEF2 ARFGEF1 RHBDD2 POR ATL1 DMXL1 PIKFYVE SNX14 FIG4 VPS13A RMC1 SLC29A1 VPS13B

4.70e-0688610817int:RAB7A
InteractionNPTN interactions

MMS22L GBF1 ARFGEF2 ARFGEF1 PIKFYVE MDN1 XPO5 FIG4 GNPAT

1.89e-052781089int:NPTN
InteractionGPR17 interactions

MMS22L GBF1 VPS8 ARFGEF2 ARFGEF1 MDN1 XPO5 ATL2 SLC29A1

2.17e-052831089int:GPR17
InteractionCSGALNACT1 interactions

ARFGEF2 ARFGEF1 SRCAP NEU2 CSGALNACT2

2.39e-05641085int:CSGALNACT1
InteractionSIGLECL1 interactions

VPS8 ARFGEF2 ARFGEF1 EXOC8 SNX14 SLC29A1

3.27e-051131086int:SIGLECL1
InteractionGPR182 interactions

MMS22L GBF1 ARFGEF2 ARFGEF1 SMPD4 SNX14 MDN1 XPO5 SLC39A6 ATL2 GNPAT

3.32e-0545510811int:GPR182
InteractionGPR45 interactions

MMS22L GBF1 VPS8 ARFGEF1 SMPD4 MDN1 XPO5 SLC39A6 ATL2

3.43e-053001089int:GPR45
InteractionRAB4A interactions

TBC1D5 VPS8 ARFGEF2 ARFGEF1 POR SMPD4 DMXL1 PIKFYVE VPS13A SLC39A6 VPS13B

3.46e-0545710811int:RAB4A
InteractionNELFA interactions

AGO2 NCBP1 SSRP1 SMARCD1 ATL2

1.11e-04881085int:NELFA
InteractionHCST interactions

GBF1 VPS8 EXOC8 MDN1 XPO5 ATL2 GNPAT

1.19e-042051087int:HCST
InteractionSRGAP1 interactions

ARHGAP26 ARHGEF10L EXOC8 KLHL7 DMD

1.37e-04921085int:SRGAP1
InteractionRAB11A interactions

GBF1 TBC1D5 VPS8 ARFGEF2 ARFGEF1 SMPD4 PTCH1 DMXL1 XPO5 ARHGEF10 VPS13A SLC39A6 SLC29A1 VPS13B

1.39e-0483010814int:RAB11A
InteractionATG9A interactions

GBF1 TBC1D5 VPS8 SMPD4 SRCAP DMXL1 PIKFYVE FIG4 RMC1 TRIM36

1.40e-0444510810int:ATG9A
InteractionFPR1 interactions

GBF1 VPS8 ARFGEF2 ARFGEF1 XPO5 ATL2

1.41e-041471086int:FPR1
InteractionPIKFYVE interactions

GBF1 PTCH1 PIKFYVE FIG4

1.49e-04501084int:PIKFYVE
InteractionELOVL5 interactions

GBF1 ARFGEF2 ARFGEF1 RHBDD2 POR SMPD4 VPS13A SLC39A6 VPS13B

1.51e-043641089int:ELOVL5
InteractionCHN2 interactions

ARHGAP26 EXOC8 KLHL7 SMARCD1 DMD

1.75e-04971085int:CHN2
InteractionCD40 interactions

TRAF3IP2 GBF1 ARFGEF2 ARFGEF1 FAF1 XPO5

1.76e-041531086int:CD40
GeneFamilySerpin peptidase inhibitors

SERPINA6 SERPINA2 SERPINA5

2.75e-0437623739
GeneFamilyCollagens

COL6A2 COL6A3 COL6A5

5.25e-0446623490
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

GBF1 AGO2 ARFGEF1 ATP8B1 TDRD7 PIKFYVE SEC24D MDN1 ARHGEF10 STAU2 VPS13A PIP5K1A DMD VPS13B PLCE1

2.09e-0685610715M4500
CoexpressionGSE11864_CSF1_VS_CSF1_IFNG_IN_MAC_UP

APMAP VPS8 RHBDD2 POR IGBP1 FIG4 VPS13A

1.68e-051971077M3133
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_DN

AGO2 ARHGEF10 DMD VPS13B PLCE1

2.47e-05841075M13008
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN

AGO2 ATP8B1 ARHGEF10 VPS13B PLCE1

2.61e-05851075M10575
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD SERPINA6 PTCHD4 KCNC1 PLCE1

5.54e-061791106d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

6.90e-0618611066379609b7ace80683f5754b16aa77f11b43766ae
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

7.80e-061901106d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

7.80e-061901106305fbef734c350cfbf786ca7ff6e07093aab56ea
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

7.80e-0619011068c9c230a509afaeee50644153974a5642b01a2b8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

8.28e-0619211060003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

8.53e-06193110653bcd50892c379b2a571751f6eb1062436339fe7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2 PLCE1

8.53e-061931106c4b22b62f3cc7bf0ec0eba76e1504c236290bbc9
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 COL6A3 SEC24D CSGALNACT2 DDX3Y PLCE1

9.31e-061961106b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCellfacs-Lung-nan-3m|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 COL6A3 SEC24D CSGALNACT2 DDX3Y PLCE1

9.31e-061961106787c6cd92035e0b1108c2c086c42a229016e476b
ToppCellASK454-Epithelial-Type_2|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

AGO2 SMPD4 ANO5 SH3PXD2A AADAT

2.22e-051361105ff9a5e111993fdb3ac64c5ef269e3460ff994517
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 MASP1 TMEM44 SMARCD1 DDX3Y

5.93e-0516711057f3224af9b30082b927a822b91f96e0c88151b4e
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 MASP1 TMEM44 SMARCD1 DDX3Y

5.93e-051671105a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCellfacs-Brain_Myeloid-Hippocampus-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 MASP1 TMEM44 SMARCD1 DDX3Y

5.93e-0516711050e746483773bde6582874a33591ab2a578d724eb
ToppCell-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

COL6A2 COL6A3 COL6A5 TNFRSF17 SERPINA5

6.27e-0516911058ebe9a88111c53a09c25a7b6a164a0a17880458d
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-microglial_cell|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 MASP1 TMEM44 SMARCD1 DDX3Y

6.45e-051701105b4f2c05db2c2591561fd42febc72eed3b5e8f9fb
ToppCellfacs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 MTERF3 ARHGEF10L ARHGEF10 FIG4

8.45e-0518011057368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

NCBP1 SEC24D FSD1L WDR12 ZNF654

9.13e-051831105310ad42b2b5d8ddd01d3a12db338f80ac1f5d08e
ToppCellfacs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AGO2 TNFRSF17 SEC24D ARHGEF10 PLCE1

9.13e-051831105b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 PLCE1

9.13e-05183110504d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NCBP1 SEC24D FSD1L WDR12 ZNF654

9.13e-051831105fef51dcf180e6d4e136362c7e140ec5ef372e6d0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 ASTN2 PLCE1

1.01e-041871105d413fb4b1531b297af5012a392b88128510c2de8
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.04e-0418811058de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL6A2 COL6A3 COL6A5 PTCH1 ASTN2

1.06e-0418911052a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.09e-0419011053f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.09e-0419011050acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.09e-041901105e58e4b6fbeb4368f738adac67ec10879c0966f0f
ToppCellproximal-Hematologic-Platelet/Megakaryocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SMPD4 NCBP1 PTCHD4 CFAP54 TRIM36

1.14e-041921105522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCellproximal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SMPD4 NCBP1 PTCHD4 CFAP54 TRIM36

1.14e-041921105f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCell10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

COL6A3 ARHGAP26 ARFGEF1 GLS DDX3Y

1.14e-04192110547646d7e4990be85072987f92bf18d52f8da752e
ToppCellproximal-Hematologic-Platelet/Megakaryocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SMPD4 NCBP1 PTCHD4 CFAP54 TRIM36

1.14e-04192110557899a905ca3e336bb7f31edc6418a2546b9891a
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_pericyte_(14)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

MASP1 ARHGAP26 ATP8B1 DMD PLCE1

1.14e-0419211055000440dc1ed17e7474d340921bdff945646f27e
ToppCellfacs-Aorta-Heart-3m-Mesenchymal|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 POR ARHGEF10L SEC24D PLCE1

1.14e-0419211050dc1f46e40346ed0b286e53b106a812441575100
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 CALB2 DGKD PTCHD4 PLCE1

1.14e-041921105bf1943715085c4124b1675888b0615c9500ec888
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2

1.17e-0419311054979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 DGKD PTCHD4 KCNC1 ASTN2

1.17e-0419311055581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT3 GRWD1 SLC39A6 WDR12 SLC29A1

1.20e-041941105c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 CALB2 DGKD PTCHD4 PLCE1

1.20e-0419411054f758718a1233c25c25d99fc1b7b06f906b8b0a2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLT3 CALB2 DGKD PTCHD4 PLCE1

1.20e-04194110502a9cc821c2b14aa7d0e55661a5fab66364474e1
ToppCellfacs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A2 POR ARHGEF10L SEC24D PLCE1

1.26e-0419611052029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

COL6A2 COL6A3 PTCH1 ATL1 DMD

1.35e-04199110538cfd367ee8c074c11ba54edeb7a001e375e2687
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

TBC1D5 ARHGAP26 FAF1 DMD VPS13B

1.35e-04199110594b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 ASTN2 PLCE1

1.38e-0420011051276bfa911fddada4235e12e3081baa53164574b
ToppCellNeuronal-Inhibitory|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 CALB2 DGKD PTCHD4 PLCE1

1.38e-0420011059ff8647e2de0b538e15929dca88ebb20ff7ab043
ToppCellTCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SMPD4 SSRP1 IGBP1 DROSHA SMARCD1

1.38e-042001105ad2a6da0b1ae7a9212a3c91e5eec4baa7481d8dc
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.38e-042001105c65e6336725856c4b5f6aeba1cf86a23ec815d34
ToppCellTCGA-Bile_Duct-Primary_Tumor|TCGA-Bile_Duct / Sample_Type by Project: Shred V9

SMPD4 SSRP1 IGBP1 DROSHA SMARCD1

1.38e-0420011050350e5ffd36033099b7e32a1fdd790fff99790dc
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 ASTN2 PLCE1

1.38e-042001105107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.38e-042001105117a25b3b9cdbc2e198381350a8362bee25e82e7
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 ASTN2 PLCE1

1.38e-04200110545ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2|Neuronal / cells hierarchy compared to all cells using T-Statistic

FLT3 DGKD PTCHD4 KCNC1 PLCE1

1.38e-042001105d459e51507bf26865e6e7e04411379ec82a3edf8
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

COL6A2 TBC1D5 MTERF3 VPS8

1.54e-041091104cc43c221487a712546917cc3253c158a1fc1fd7a
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO5 PTCHD4 SLITRK1 TRIM66

1.54e-0410911040d4128af237afcc0adb4dfdd206fa3ddbe5b0e86
Diseasealpha-1-antitrypsin measurement

SERPINA6 SERPINA2 SERPINA5

3.94e-0691083EFO_0008327
Diseasehereditary spastic paraplegia 3A (implicated_via_orthology)

ATL1 ATL2

3.97e-0531082DOID:0110791 (implicated_via_orthology)
DiseaseCohen syndrome (implicated_via_orthology)

VPS13A VPS13B

3.97e-0531082DOID:0111590 (implicated_via_orthology)
DiseaseUllrich congenital muscular dystrophy

COL6A2 COL6A3

7.93e-0541082cv:C4551860
DiseaseBethlem myopathy

COL6A2 COL6A3

7.93e-0541082cv:C1834674
DiseaseBETHLEM MYOPATHY 1

COL6A2 COL6A3

7.93e-0541082C1834674
DiseaseUllrich congenital muscular dystrophy 1

COL6A2 COL6A3

7.93e-0541082C0410179
DiseaseBethlem myopathy (is_implicated_in)

COL6A2 COL6A3

7.93e-0541082DOID:0050663 (is_implicated_in)
DiseaseUllrich congenital muscular dystrophy (is_implicated_in)

COL6A2 COL6A3

7.93e-0541082DOID:0050558 (is_implicated_in)
Diseaseacute myelomonocytic leukemia (is_implicated_in)

FLT3 ARHGAP26

7.93e-0541082DOID:0081082 (is_implicated_in)
DiseaseBilateral Wilms Tumor

COL6A3 XPO5 DROSHA

1.63e-04291083C2930471
Diseasecortical thickness

TBC1D5 ARFGEF2 PTCH1 PXK FAF1 XPO5 SH3PXD2A GLS STAU2 ASTN2 AGBL2 TRIM36 PLCE1

2.18e-04111310813EFO_0004840
Diseasetotal blood protein measurement

FLT3 ARHGAP26 DGKD TNFRSF17 PXK SH3PXD2A SERPINA5 PLCE1

2.52e-044491088EFO_0004536
Diseaseseptic shock

MMS22L ARHGAP26

2.75e-0471082EFO_0006834
Diseasealpha-1-antichymotrypsin complex measurement

PIKFYVE SERPINA5

2.75e-0471082EFO_0008018
DiseaseNephroblastoma

COL6A3 XPO5 DROSHA

3.12e-04361083C0027708
Diseasesmall vessel stroke

ARHGAP26 PTCH1 SH3PXD2A WDR12

4.35e-04961084EFO_1001504
Diseasemood instability measurement

MMS22L AGO2 CALB2 AGBL2

1.28e-031281084EFO_0008475
Diseaseserum alanine aminotransferase measurement

GBF1 ANO5 FAM227B ATP8B1 PTCH1 SERPINA6 SERPINA2 RMC1 AGBL2 PLCE1

1.34e-0386910810EFO_0004735
DiseaseYu-Zhi constitution type

RRN3P2 FREM2

1.35e-03151082EFO_0007638
Diseaseaspartate aminotransferase measurement

TBC1D5 ANO5 FAM227B ATP8B1 PTCH1 SERPINA6 SERPINA2 PXK ASTN2 PLCE1

1.80e-0390410810EFO_0004736
DiseaseFEV/FEC ratio

COL6A3 PDE9A HCN1 ARHGAP26 DGKD FAM227B PTCH1 FAF1 FREM2 KLHL7 SH3PXD2A ASTN2

1.80e-03122810812EFO_0004713
Diseaseneuroticism measurement

MMS22L AGO2 CALB2 HCN1 PTCH1 ARHGEF10L NEU2 ASTN2 AGBL2 SSX3

1.87e-0390910810EFO_0007660
Diseaseneurodegenerative disease (implicated_via_orthology)

TBPL2 PTCH1 MICU1 FIG4

2.02e-031451084DOID:1289 (implicated_via_orthology)
Diseasestomach cancer (is_implicated_in)

PTCH1 TMEM260 EEF2

2.37e-03721083DOID:10534 (is_implicated_in)
Diseasecortisol measurement

SERPINA6 SERPINA2

2.42e-03201082EFO_0005843
Diseaseforced expiratory volume

ARFGEF2 FAM227B PTCH1 FAF1 FIG4 SH3PXD2A DROSHA ASTN2 RMC1

2.48e-037891089EFO_0004314
Diseaseexecutive function measurement

COL6A3 TBC1D5 ARFGEF2 ARHGEF10L XPO5 TRIM36

2.65e-033761086EFO_0009332
DiseaseParkinson's disease (implicated_via_orthology)

RRN3P2 PTCH1 GIPC3 VPS13A

2.69e-031571084DOID:14330 (implicated_via_orthology)
DiseaseCCL24 measurement

RHBDD2 POR

2.92e-03221082EFO_0009418
Diseasetriacylglycerol 58:9 measurement

GBF1 FAM227B

2.92e-03221082EFO_0010443

Protein segments in the cluster

PeptideGeneStartEntry
FMSIPLSRKDAFFQI

FAM227B

236

Q96M60
LQFNKFRVPTFLSMD

AADAT

236

Q8N5Z0
RFPQFILLLQDMLKN

ARHGEF10

566

O15013
RFPQFILLLQDMLKN

ARHGEF10L

461

Q9HCE6
QKPRFLEFFTQVMLK

CFAP54

1331

Q96N23
LRDFIFKNPAISEMV

CFAP54

1421

Q96N23
HLTPEFFLIQNFVKM

CFAP61

426

Q8NHU2
FFLIQNFVKMVPFNT

CFAP61

431

Q8NHU2
INEETMPAKRFNLFL

ANO5

41

Q75V66
VFRIFDNMKLPEQQT

ARFGEF1

1431

Q9Y6D6
FLRMKQVKIFPSCLF

GVINP1

1596

Q7Z2Y8
RIVFRIFDNMKLPEQ

ARFGEF2

1376

Q9Y6D5
FTLRLVQPKRAFDMI

GIPC3

186

Q8TF64
FKLFSQETVMKFVPR

APMAP

346

Q9HDC9
LQDVSMKFRLFQKPA

DMD

1451

P11532
MEVFLQQLRKSFEQP

DMXL1

406

Q9Y485
MTFRENNFIKDFPQL

ASTN2

796

O75129
TFIPMNLFEQFKRAA

ATP8B1

106

O43520
RTIKLQANFFEMDIP

AGO2

36

Q9UKV8
LTQAFRRKFVIPDFM

GLS

211

O94925
QAPDLTLIVEFIFMF

MGAT4A

301

Q9UM21
HQFLMDTIFQPFLKD

MDN1

5266

Q9NU22
MFVRKSQFRLPFKAT

POR

511

P16435
QKNLFLVIFQRFIMI

NCBP1

706

Q09161
FLRDEQAQMKPIFSF

GRWD1

196

Q9BQ67
FFSFLKSQRMSQVVP

MMS22L

721

Q6ZRQ5
FSQERQMLQTLKFLP

FSD1L

181

Q9BXM9
LLFNNTRPVMVFTKQ

FREM2

1581

Q5SZK8
LSTPQRNFEIAFKMF

MICU1

216

Q9BPX6
KPFILTRNMAQAKVF

IGBP1

241

P78318
TAQIGFIKFVLIPMF

PDE9A

511

O76083
MFVFSPDQFQRLLKI

METTL9

126

Q9H1A3
NRQPFMVDILAKVRF

KLHL7

221

Q8IXQ5
DVQVILFLPNFVKML

EDC3

361

Q96F86
MSLAFKIFFPQTLRA

LIG3

1

P49916
TNQPELQVMIFIFLF

OR6C4

16

Q8NGE1
FKLLMFPESRIFQAE

EXOC8

251

Q8IYI6
FQRFMCNTVFKKIPL

PIP5K1A

441

Q99755
FRVAKVFAQPNLAEM

SMPD4

506

Q9NXE4
MEFKAVQQVQRLPFL

POMP

81

Q9Y244
EIVFLMFTLKQAFPA

NEU2

361

Q9Y3R4
QFTKMFTLNIRRKPQ

FLT3

426

P36888
LKQMPRLEVQSFLDF

PIKFYVE

1876

Q9Y2I7
KYQTVMFNRPFLVII

SERPINA2

386

P20848
IPFESFTLMKVFQLE

CSGALNACT2

146

Q8N6G5
PNFVTAMLSKLRFEV

HCN1

481

O60741
FTFEFLMRVIFCPNK

KCNC1

256

P48547
MEETFLKPFQSLIFL

ATL1

201

Q8WXF7
LFFTTIMQNFRFKSP

CYP2A13

451

Q16696
KFGLLNIVMEPFFKR

GNPAT

256

O15228
FDQMFQRFGSPIIIL

FIG4

361

Q92562
FPFVKTFINKMINSL

COL6A5

46

A8TX70
RPFLMFIVDNNILFL

SERPINA5

386

P05154
FLMRKVAVFFSNTPT

COL6A3

2506

P12111
LLFHMKQFVPQFISQ

COL6A2

66

P12110
IYQKPFQTLMFLIRD

ATL2

231

Q8NHH9
AQLLRDIFVFKVLPM

AGBL2

486

Q5U5Z8
KQFLQRFPETLMEIE

MASP1

591

P48740
RFKQLLNPAQVFDLM

DGKD

341

Q16760
VDMVQLLFTRLPQFK

GBF1

186

Q92538
RPTQSFVKFMAQQIF

KIAA1210

1191

Q9ULL0
MSRLLPVQENFLLKF

CALB2

176

P22676
QLILDPIFKVFDAIM

EEF2

291

P13639
RTQKTDQFPLFLIIM

FAF1

441

Q9UNN5
ATFPKEIQMLARDFL

DDX3Y

381

O15523
ILRFNQPFIIMIFDH

SERPINA6

376

P08185
AQMVRKAPFLLNFSV

MTERF3

241

Q96E29
LFFVTNTIPKMLVNF

OR1D4

71

P47884
LFFVTNTIPKMLVNF

OR1D5

71

P58170
MNVCFFPRLKEFILN

DROSHA

1241

Q9NRR4
QPFTLVTIGMQKFFI

TRIM36

631

Q9NQ86
IFESQRMKFSEIPQR

SMARCD1

346

Q96GM5
LPQQRKMAEIFKTVF

PLCE1

1491

Q9P212
KSIRFIVFNPSFVFM

PTCHD4

636

Q6ZW05
MIFQPQLFKDSITRE

SLC66A1L

101

A1A4F0
RKMFEFVEPLLAFLQ

ARHGAP26

191

Q9UNA1
VVFNFAMVLLIFPAI

PTCH1

581

Q13635
ILPSFMRNKRVTDFQ

SSX3

66

Q99909
TEDPQLQVLLFMFLF

OR6C68

16

A6NDL8
NEFISPMEKLFRVIA

VPS8

691

Q8N3P4
MFRKLPFQAVTAQLA

TDRD7

1011

Q8NHU6
FKQQTIRELFDMPLE

SRCAP

2201

Q6ZRS2
KQREQPEMVFRQFLV

SEC24D

991

O94855
KVQLDALPFFVITMI

SLC29A1

131

Q99808
VPLMNRVFFKFLLSF

SLC39A6

346

Q13433
RLFLLPHKDQRQMFF

SSRP1

241

Q08945
FIKQGSMNFRFIPVL

TRAF3IP2

506

O43734
SMNFRFIPVLFPNAK

TRAF3IP2

511

O43734
MNALFVQFAEVFPLK

TMEM35B

36

Q8NCS4
FVFRPISANAKLVMN

VPS13A

251

Q96RL7
PVNFFRKDFMLLSND

SLITRK1

561

Q96PX8
LVFEIALKRNMPVSF

STAU2

211

Q9NUL3
LLFRFMNFLKQEGAV

SNX14

346

Q9Y5W7
FFKQIFGDQALMRPT

RMC1

641

Q96DM3
QTFPFSLMRRISVFK

RHBDD2

216

Q6NTF9
KFFDLQMQLLDKFPI

SH3PXD2A

46

Q5TCZ1
LRTATNVRVIFPFMK

ZNF654

326

Q8IZM8
SPVFKTVLERMQRFF

XPO5

826

Q9HAV4
IALQQVSMFFRSEPK

PXK

131

Q7Z7A4
AAIDLVNFMFILFPV

TMEM44

96

Q2T9K0
FLARAKFIPLMIREQ

RRN3P2

296

A6NIE6
NKTFNLMRFIFRTDP

ZNF404

76

Q494X3
NTNRAPEKIVTFKMF

VPS13B

3376

Q7Z7G8
FPEMQFFQQENVRKI

TBC1D5

171

Q92609
VEFDFLIKGQFLRMP

WDR12

51

Q9GZL7
MRTPQLALLQVFFLV

TCTN3

1

Q6NUS6
PFLFSKELIVFQMQR

TRIM66

216

O15016
FVLMFLLRKINSEPL

TNFRSF17

71

Q02223
MLFNQFPGFKEVRLV

SNRPA

226

P09012
FPLVFNARMVFEKVF

SPATA6

51

Q9NWH7
LGFPARFLDFKIQNM

TBPL2

281

Q6SJ96
LANFITPMIFAKIIR

TMC7

416

Q7Z402
QARMKTPFFIFNLAE

TMEM260

591

Q9NX78
EELFMQIEALFPQKF

ZRANB3

196

Q5FWF4