Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionextracellular matrix structural constituent

LAMA2 LAMB2 FBN1 FBN2 SSPOP FBN3

1.27e-07188266GO:0005201
GeneOntologyMolecularFunctioncalcium ion binding

UMOD LTBP3 FBN1 PLA2G2F FBN2 MEGF6 EGFL8 TENM2 FBN3

2.47e-07749269GO:0005509
GeneOntologyMolecularFunctionprotein heterodimerization activity

TENM1 ERBB2 ERBB3 TENM4 TENM3 TENM2

9.92e-06398266GO:0046982
GeneOntologyMolecularFunctionErbB-3 class receptor binding

ERBB2 ERBB3

2.44e-056262GO:0043125
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

ERBB2 ERBB3 TIE1

8.11e-0565263GO:0004714
GeneOntologyMolecularFunctioncell adhesion molecule binding

TENM1 LAMB2 FBN1 TENM4 TENM3 TENM2

9.80e-05599266GO:0050839
GeneOntologyMolecularFunctionextracellular matrix constituent conferring elasticity

FBN1 FBN2

1.07e-0412262GO:0030023
GeneOntologyMolecularFunctionstructural molecule activity conferring elasticity

FBN1 FBN2

1.47e-0414262GO:0097493
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

ERBB2 ERBB3 TIE1

1.80e-0485263GO:0019199
GeneOntologyMolecularFunctionprotein dimerization activity

TENM1 ERBB2 ERBB3 TENM4 TENM3 GRM6 TENM2

6.82e-041205267GO:0046983
GeneOntologyMolecularFunctionstructural molecule activity

LAMA2 LAMB2 FBN1 FBN2 SSPOP FBN3

8.29e-04891266GO:0005198
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

ERBB2 ERBB3 TIE1

8.63e-04145263GO:0004713
GeneOntologyMolecularFunctiongrowth factor binding

ERBB2 ERBB3 LTBP3

1.07e-03156263GO:0019838
GeneOntologyMolecularFunctionprotein homodimerization activity

TENM1 TENM4 TENM3 GRM6 TENM2

3.60e-03815265GO:0042803
GeneOntologyBiologicalProcessheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

TENM1 UMOD TENM4 TENM3 TENM2

1.42e-0863265GO:0007157
GeneOntologyBiologicalProcessSchwann cell differentiation

LAMA2 LAMB2 ERBB2 ERBB3

6.47e-0755264GO:0014037
GeneOntologyBiologicalProcesscell-cell adhesion

TENM1 UMOD ERBB2 PLA2G2F TENM4 TENM3 TENM2 MEGF10 PEAR1

3.89e-061077269GO:0098609
GeneOntologyBiologicalProcessperipheral nervous system development

LAMA2 LAMB2 ERBB2 ERBB3

6.61e-0698264GO:0007422
GeneOntologyBiologicalProcesssequestering of TGFbeta in extracellular matrix

FBN1 FBN2

9.15e-064262GO:0035583
GeneOntologyBiologicalProcessSchwann cell development

LAMB2 ERBB2 ERBB3

2.78e-0547263GO:0014044
GeneOntologyBiologicalProcessrecognition of apoptotic cell

MEGF10 PEAR1

3.20e-057262GO:0043654
GeneOntologyBiologicalProcesscell-cell adhesion via plasma-membrane adhesion molecules

TENM1 UMOD TENM4 TENM3 TENM2

3.95e-05313265GO:0098742
GeneOntologyBiologicalProcessglial cell development

LAMB2 ERBB2 ERBB3 TENM4

4.24e-05157264GO:0021782
GeneOntologyBiologicalProcessmaintenance of protein location in extracellular region

FBN1 FBN2

4.26e-058262GO:0071694
GeneOntologyBiologicalProcessglial cell differentiation

LAMA2 LAMB2 ERBB2 ERBB3 TENM4

4.45e-05321265GO:0010001
GeneOntologyBiologicalProcesssequestering of extracellular ligand from receptor

FBN1 FBN2

8.35e-0511262GO:0035581
GeneOntologyBiologicalProcessregulation of basement membrane organization

LAMA2 LAMB2

8.35e-0511262GO:0110011
GeneOntologyBiologicalProcessregulation of cell adhesion

LAMA2 LAMB2 ERBB2 ERBB3 PLA2G2F TENM3 MEGF10

1.12e-04927267GO:0030155
GeneOntologyBiologicalProcessextracellular regulation of signal transduction

FBN1 FBN2

1.18e-0413262GO:1900115
GeneOntologyBiologicalProcessextracellular negative regulation of signal transduction

FBN1 FBN2

1.18e-0413262GO:1900116
GeneOntologyBiologicalProcessERBB2-ERBB3 signaling pathway

ERBB2 ERBB3

1.18e-0413262GO:0038133
GeneOntologyBiologicalProcesspositive regulation of kinase activity

TENM1 ERBB2 ERBB3 FBN1 TIE1

1.33e-04405265GO:0033674
GeneOntologyBiologicalProcesspositive regulation of integrin-mediated signaling pathway

LAMA2 LAMB2

1.38e-0414262GO:2001046
GeneOntologyBiologicalProcessERBB3 signaling pathway

ERBB2 ERBB3

1.38e-0414262GO:0038129
GeneOntologyBiologicalProcessregulation of extracellular matrix organization

LAMA2 LAMB2 TIE1

1.58e-0484263GO:1903053
GeneOntologyBiologicalProcessgliogenesis

LAMA2 LAMB2 ERBB2 ERBB3 TENM4

1.86e-04435265GO:0042063
GeneOntologyBiologicalProcessmetanephros development

UMOD LAMB2 FBN1

2.28e-0495263GO:0001656
GeneOntologyBiologicalProcessheart development

ERBB2 ERBB3 FBN1 TENM4 TIE1 GLI1

2.94e-04757266GO:0007507
GeneOntologyBiologicalProcesspositive regulation of transferase activity

TENM1 ERBB2 ERBB3 FBN1 TIE1

3.23e-04490265GO:0051347
GeneOntologyBiologicalProcessstriated muscle cell proliferation

TENM4 GLI1 MEGF10

3.51e-04110263GO:0014855
GeneOntologyBiologicalProcessregulation of integrin-mediated signaling pathway

LAMA2 LAMB2

3.80e-0423262GO:2001044
GeneOntologyBiologicalProcessmetanephric nephron epithelium development

UMOD LAMB2

3.80e-0423262GO:0072243
GeneOntologyBiologicalProcessaxon guidance

LAMA2 LAMB2 ERBB2 TENM2

4.20e-04285264GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

LAMA2 LAMB2 ERBB2 TENM2

4.25e-04286264GO:0097485
GeneOntologyBiologicalProcessERBB2 signaling pathway

ERBB2 ERBB3

5.26e-0427262GO:0038128
GeneOntologyBiologicalProcessmetanephric epithelium development

UMOD LAMB2

5.66e-0428262GO:0072207
GeneOntologyBiologicalProcesspositive regulation of filopodium assembly

TENM1 TENM2

9.38e-0436262GO:0051491
GeneOntologyBiologicalProcessextracellular matrix organization

LAMA2 LAMB2 ADAMTS14 TIE1

1.19e-03377264GO:0030198
GeneOntologyBiologicalProcessextracellular structure organization

LAMA2 LAMB2 ADAMTS14 TIE1

1.21e-03378264GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

LAMA2 LAMB2 ADAMTS14 TIE1

1.22e-03379264GO:0045229
GeneOntologyBiologicalProcessresponse to wounding

LAMB2 ERBB2 ERBB3 GLI1 PEAR1

1.23e-03659265GO:0009611
GeneOntologyBiologicalProcesssynaptic membrane adhesion

TENM4 TENM3

1.28e-0342262GO:0099560
GeneOntologyBiologicalProcessphagocytosis, recognition

MEGF10 PEAR1

1.28e-0342262GO:0006910
GeneOntologyBiologicalProcessbasement membrane organization

LAMA2 LAMB2

1.34e-0343262GO:0071711
GeneOntologyBiologicalProcesssynapse organization

LAMB2 ERBB2 TENM4 TENM3 GRM6

1.47e-03685265GO:0050808
GeneOntologyBiologicalProcessregulation of kinase activity

TENM1 ERBB2 ERBB3 FBN1 TIE1

1.48e-03686265GO:0043549
GeneOntologyBiologicalProcessapoptotic cell clearance

MEGF10 PEAR1

1.66e-0348262GO:0043277
GeneOntologyBiologicalProcessneuron development

TENM1 LAMA2 LAMB2 ERBB2 TENM4 TENM3 TENM2

1.77e-031463267GO:0048666
GeneOntologyBiologicalProcessregulation of muscle cell differentiation

LAMA2 LAMB2 MEGF10

1.95e-03199263GO:0051147
GeneOntologyBiologicalProcessmyelination

ERBB2 ERBB3 TENM4

2.15e-03206263GO:0042552
GeneOntologyBiologicalProcessensheathment of neurons

ERBB2 ERBB3 TENM4

2.25e-03209263GO:0007272
GeneOntologyBiologicalProcessaxon ensheathment

ERBB2 ERBB3 TENM4

2.25e-03209263GO:0008366
GeneOntologyBiologicalProcessregulation of filopodium assembly

TENM1 TENM2

2.34e-0357262GO:0051489
GeneOntologyBiologicalProcessregulation of muscle tissue development

ERBB3 MEGF10

2.34e-0357262GO:1901861
GeneOntologyBiologicalProcessextracellular matrix assembly

LAMB2 TIE1

2.50e-0359262GO:0085029
GeneOntologyBiologicalProcesspositive regulation of phosphorylation

TENM1 ERBB2 ERBB3 FBN1 TIE1

2.59e-03780265GO:0042327
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

ERBB2 ERBB3 LTBP3 FBN1 FBN2 TIE1

3.04e-031186266GO:0007167
GeneOntologyBiologicalProcessregulation of transferase activity

TENM1 ERBB2 ERBB3 FBN1 TIE1

3.05e-03810265GO:0051338
GeneOntologyCellularComponentextracellular matrix

LAMA2 LAMB2 LTBP3 FBN1 FBN2 ADAMTS14 MEGF6 SSPOP FBN3

5.41e-08656269GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

LAMA2 LAMB2 LTBP3 FBN1 FBN2 ADAMTS14 MEGF6 SSPOP FBN3

5.56e-08658269GO:0030312
GeneOntologyCellularComponentmicrofibril

FBN1 FBN2 FBN3

4.84e-0713263GO:0001527
GeneOntologyCellularComponentERBB3:ERBB2 complex

ERBB2 ERBB3

1.49e-062262GO:0038143
GeneOntologyCellularComponentcollagen-containing extracellular matrix

LAMA2 LAMB2 LTBP3 FBN1 FBN2 MEGF6 SSPOP

2.80e-06530267GO:0062023
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

LAMA2 LAMB2

2.00e-0417262GO:0098637
GeneOntologyCellularComponentneuromuscular junction

LAMA2 LAMB2 ERBB2

3.56e-04112263GO:0031594
GeneOntologyCellularComponentbasement membrane

LAMA2 LAMB2 FBN1

4.57e-04122263GO:0005604
GeneOntologyCellularComponentsynaptic membrane

ERBB2 ERBB3 TENM3 GRM6 TENM2

6.71e-04583265GO:0097060
GeneOntologyCellularComponentphagocytic cup

MEGF10 PEAR1

6.77e-0431262GO:0001891
GeneOntologyCellularComponentsynaptic cleft

LAMA2 LAMB2

7.67e-0433262GO:0043083
GeneOntologyCellularComponentpostsynaptic membrane

ERBB2 ERBB3 GRM6 TENM2

1.48e-03405264GO:0045211
GeneOntologyCellularComponentprotein complex involved in cell adhesion

LAMA2 LAMB2

2.44e-0359262GO:0098636
GeneOntologyCellularComponentGolgi cisterna membrane

ZDHHC14 NAGPA

6.06e-0394262GO:0032580
GeneOntologyCellularComponentbasolateral plasma membrane

UMOD ERBB2 ERBB3

7.12e-03320263GO:0016323
GeneOntologyCellularComponentpostsynapse

LAMA2 ERBB2 ERBB3 GRM6 TENM2

7.59e-031018265GO:0098794
GeneOntologyCellularComponentbasal plasma membrane

UMOD ERBB2 ERBB3

9.38e-03354263GO:0009925
GeneOntologyCellularComponentbasal part of cell

UMOD ERBB2 ERBB3

1.12e-02378263GO:0045178
GeneOntologyCellularComponentGolgi cisterna

ZDHHC14 NAGPA

1.22e-02135262GO:0031985
HumanPhenoFifth metacarpal with ulnar notch

LTBP3 FBN1

8.09e-062152HP:0005900
HumanPhenoAbnormal upper to lower segment ratio

FBN1 FBN2

2.42e-053152HP:0012772
MousePhenoabnormal Schwann cell precursor morphology

ERBB2 ERBB3

9.20e-063252MP:0004074
MousePhenodecreased Schwann cell precursor number

ERBB2 ERBB3

9.20e-063252MP:0004075
MousePhenoabnormal Schwann cell morphology

LAMA2 ERBB2 ERBB3

3.77e-0537253MP:0001106
MousePhenoabnormal PNS glial cell morphology

LAMA2 ERBB2 ERBB3

3.77e-0537253MP:0001105
MousePhenoabnormal sensory neuron morphology

LAMA2 LAMB2 ERBB2 TENM3 TENM2 MEGF10

1.49e-04473256MP:0000965
MousePhenoabnormal somatic sensory system morphology

LAMA2 LAMB2 ERBB2 ERBB3 TENM3 TENM2 MEGF10

1.70e-04702257MP:0000959
MousePhenodecreased respiration

ERBB2 ERBB3 FBN1 TIE1

2.19e-04170254MP:0014274
MousePhenoatrioventricular valve regurgitation

ERBB3 FBN1

2.37e-0413252MP:0006046
MousePhenoabnormal petrosal ganglion morphology

ERBB2 ERBB3

2.76e-0414252MP:0001084
MousePhenoabnormal somatic nervous system morphology

LAMA2 LAMB2 ERBB2 ERBB3 FBN2 TENM3 TENM2 MEGF10

2.85e-041025258MP:0002752
MousePhenoabnormal glial cell morphology

LAMA2 LAMB2 ERBB2 ERBB3 TENM4

3.15e-04345255MP:0003634
MousePhenohindlimb paralysis

LAMA2 LTBP3 TENM4

3.65e-0479253MP:0000755
MousePhenoabnormal neuroendocrine cell morphology

ERBB3 FBN1

4.11e-0417252MP:0010913
MousePhenolimb paralysis

LAMA2 LTBP3 TENM4

4.22e-0483253MP:0013147
MousePhenodecreased atrioventricular cushion size

ERBB2 ERBB3

4.62e-0418252MP:0000301
MousePhenopoor circulation

ERBB2 ERBB3

5.15e-0419252MP:0001633
MousePhenoabnormal ventral spinal root morphology

ERBB2 ERBB3

5.15e-0419252MP:0003993
MousePhenoabnormal sensory neuron innervation pattern

ERBB2 TENM3 TENM2

5.71e-0492253MP:0000968
DomainEGF_1

TENM1 LAMA2 UMOD LAMB2 LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA SSPOP TENM2 FBN3 MEGF10 PEAR1

2.10e-282552618PS00022
DomainEGF_2

TENM1 LAMA2 UMOD LAMB2 LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA SSPOP TENM2 FBN3 MEGF10 PEAR1

4.28e-282652618PS01186
DomainEGF

TENM1 LAMA2 UMOD LAMB2 LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA TENM2 FBN3 MEGF10 PEAR1

7.82e-272352617SM00181
DomainEGF-like_dom

TENM1 LAMA2 UMOD LAMB2 LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA TENM2 FBN3 MEGF10 PEAR1

2.15e-262492617IPR000742
DomainEGF-like_CS

TENM1 LAMA2 UMOD LAMB2 LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA TENM2 FBN3 MEGF10 PEAR1

4.88e-262612617IPR013032
DomainEGF_3

TENM1 UMOD LTBP3 FBN1 FBN2 TENM4 MEGF6 EGFL8 TENM3 TIE1 NAGPA SSPOP TENM2 FBN3 MEGF10 PEAR1

1.12e-242352616PS50026
DomainGrowth_fac_rcpt_

UMOD LAMB2 ERBB2 ERBB3 LTBP3 FBN1 FBN2 MEGF6 TIE1 FBN3

5.85e-151562610IPR009030
DomainEGF_extracell

TENM1 TENM4 MEGF6 TENM3 TIE1 NAGPA MEGF10

1.54e-1260267IPR013111
DomainEGF_2

TENM1 TENM4 MEGF6 TENM3 TIE1 NAGPA MEGF10

1.54e-1260267PF07974
DomainTox-GHH_dom

TENM1 TENM4 TENM3 TENM2

2.95e-124264IPR028916
DomainTENEURIN_N

TENM1 TENM4 TENM3 TENM2

2.95e-124264PS51361
DomainTen_N

TENM1 TENM4 TENM3 TENM2

2.95e-124264IPR009471
DomainTox-GHH

TENM1 TENM4 TENM3 TENM2

2.95e-124264PF15636
DomainTen_N

TENM1 TENM4 TENM3 TENM2

2.95e-124264PF06484
DomainEGF_CA

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 TENM2 FBN3

3.72e-12122268SM00179
DomainEGF-like_Ca-bd_dom

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 TENM2 FBN3

4.25e-12124268IPR001881
DomainYD

TENM1 TENM4 TENM3 TENM2

1.47e-115264IPR006530
DomainEGF_CA

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 FBN3

2.10e-1186267PF07645
DomainEMI

MEGF6 EGFL8 SSPOP MEGF10 PEAR1

2.13e-1117265PS51041
DomainEGF_Ca-bd_CS

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 FBN3

4.96e-1197267IPR018097
DomainEGF_CA

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 FBN3

5.74e-1199267PS01187
DomainASX_HYDROXYL

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 FBN3

6.17e-11100267PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

UMOD LTBP3 FBN1 FBN2 MEGF6 EGFL8 FBN3

9.34e-11106267IPR000152
DomainTB

LTBP3 FBN1 FBN2 FBN3

1.03e-107264PF00683
Domain-

LTBP3 FBN1 FBN2 FBN3

2.06e-1082643.90.290.10
DomainhEGF

LTBP3 FBN2 MEGF6 FBN3 MEGF10

3.34e-1028265PF12661
DomainTB

LTBP3 FBN1 FBN2 FBN3

3.70e-109264PS51364
DomainTB_dom

LTBP3 FBN1 FBN2 FBN3

3.70e-109264IPR017878
DomainLaminin_EGF

LAMA2 LAMB2 MEGF6 MEGF10 PEAR1

1.10e-0935265PF00053
DomainEGF_Lam

LAMA2 LAMB2 MEGF6 MEGF10 PEAR1

1.10e-0935265SM00180
DomainLaminin_EGF

LAMA2 LAMB2 MEGF6 MEGF10 PEAR1

1.69e-0938265IPR002049
DomainNHL

TENM1 TENM4 TENM3 TENM2

2.09e-0913264PS51125
DomainRhs_assc_core

TENM4 TENM3 TENM2

2.39e-093263IPR022385
DomainFBN

FBN1 FBN2 FBN3

2.39e-093263IPR011398
DomainEMI_domain

MEGF6 EGFL8 MEGF10 PEAR1

5.31e-0916264IPR011489
DomainEGF

UMOD MEGF6 EGFL8 TIE1 NAGPA FBN3

1.72e-08126266PF00008
DomaincEGF

LTBP3 FBN1 FBN2 FBN3

4.32e-0826264IPR026823
DomaincEGF

LTBP3 FBN1 FBN2 FBN3

4.32e-0826264PF12662
Domain-

TENM1 TENM4 TENM3 TENM2

2.35e-07392642.120.10.30
Domain6-blade_b-propeller_TolB-like

TENM1 TENM4 TENM3 TENM2

4.63e-0746264IPR011042
DomainCarboxyPept-like_regulatory

TENM4 TENM3 TENM2

1.61e-0617263IPR008969
DomainTyr_kinase_EGF/ERB/XmrK_rcpt

ERBB2 ERBB3

1.12e-054262IPR016245
DomainGF_recep_IV

ERBB2 ERBB3

2.79e-056262PF14843
DomainGF_recep_IV

ERBB2 ERBB3

2.79e-056262IPR032778
DomainFurin-like

ERBB2 ERBB3

3.90e-057262PF00757
DomainRcpt_L-dom

ERBB2 ERBB3

3.90e-057262IPR000494
DomainFurin-like_Cys-rich_dom

ERBB2 ERBB3

3.90e-057262IPR006211
DomainRecep_L_domain

ERBB2 ERBB3

3.90e-057262PF01030
Domain-

ERBB2 ERBB3

3.90e-0572623.80.20.20
DomainLAMININ_NTER

LAMA2 LAMB2

2.21e-0416262PS51117
DomainLaminin_N

LAMA2 LAMB2

2.21e-0416262PF00055
DomainLaminin_N

LAMA2 LAMB2

2.21e-0416262IPR008211
DomainLamNT

LAMA2 LAMB2

2.21e-0416262SM00136
DomainTyrKc

ERBB2 ERBB3 TIE1

2.43e-0488263SM00219
DomainTyr_kinase_cat_dom

ERBB2 ERBB3 TIE1

2.43e-0488263IPR020635
DomainFurin_repeat

ERBB2 ERBB3

2.81e-0418262IPR006212
DomainFU

ERBB2 ERBB3

2.81e-0418262SM00261
DomainGalactose-bd-like

LAMA2 LAMB2 SSPOP

2.95e-0494263IPR008979
DomainPROTEIN_KINASE_TYR

ERBB2 ERBB3 TIE1

3.24e-0497263PS00109
DomainTyr_kinase_AS

ERBB2 ERBB3 TIE1

3.24e-0497263IPR008266
DomainPkinase_Tyr

ERBB2 ERBB3 TIE1

7.45e-04129263PF07714
DomainEGF_LAM_2

LAMA2 LAMB2

7.91e-0430262PS50027
DomainEGF_LAM_1

LAMA2 LAMB2

7.91e-0430262PS01248
DomainSer-Thr/Tyr_kinase_cat_dom

ERBB2 ERBB3 TIE1

9.06e-04138263IPR001245
DomainTSP_1

ADAMTS14 SSPOP

3.45e-0363262PF00090
DomainTSP1

ADAMTS14 SSPOP

3.67e-0365262SM00209
DomainTSP1_rpt

ADAMTS14 SSPOP

3.67e-0365262IPR000884
DomainTSP1

ADAMTS14 SSPOP

3.67e-0365262PS50092
Domain-

LAMA2 SSPOP

4.61e-03732622.60.120.260
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LAMA2 LAMB2 LTBP3 FBN1 FBN2 ADAMTS14 FBN3

2.99e-08300177M610
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP3 FBN1 FBN2 FBN3

9.33e-0837174M27134
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP3 FBN1 FBN2 FBN3

1.91e-0744174M26969
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

LAMA2 LAMB2 ERBB2 ERBB3

2.29e-0746174M239
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

FBN1 FBN2 FBN3

3.30e-0625173M39713
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP3 FBN1 FBN2

7.07e-0632173MM14854
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LTBP3 FBN1 FBN2 ADAMTS14 MEGF6

1.02e-05258175MM14572
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP3 FBN1 FBN2

1.30e-0539173MM14601
PathwayREACTOME_GRB7_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB3

1.37e-055172M26937
PathwayKEGG_MEDICUS_REFERENCE_PLASMIN_MEDIATED_ACTIVATION_OF_LATENT_TGF_BETA

LTBP3 FBN1

3.82e-058172M47850
PathwayWP_ALPHA_6_BETA_4_INTEGRIN_SIGNALING_PATHWAY

LAMA2 LAMB2 ERBB2

6.36e-0566173MM15925
PathwayPID_INTEGRIN1_PATHWAY

LAMA2 LAMB2 FBN1

6.36e-0566173M18
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB3

7.48e-0511172MM15478
PathwayPID_INTEGRIN4_PATHWAY

LAMA2 LAMB2

7.48e-0511172M158
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

ERBB2 ERBB3

8.97e-0512172MM14550
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

ERBB2 ERBB3

1.06e-0413172M549
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB3

1.06e-0413172MM15320
PathwayREACTOME_ERBB2_ACTIVATES_PTK6_SIGNALING

ERBB2 ERBB3

1.06e-0413172M27729
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB3

1.24e-0414172MM14761
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB3

1.24e-0414172MM14531
PathwayPID_ERBB_NETWORK_PATHWAY

ERBB2 ERBB3

1.42e-0415172M201
PathwayREACTOME_ERBB2_REGULATES_CELL_MOTILITY

ERBB2 ERBB3

1.42e-0415172M27608
PathwayREACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB3

1.63e-0416172M570
PathwayREACTOME_SHC1_EVENTS_IN_ERBB2_SIGNALING

ERBB2 ERBB3

3.12e-0422172M26929
PathwayBIOCARTA_HER2_PATHWAY

ERBB2 ERBB3

3.41e-0423172MM1480
PathwayBIOCARTA_HER2_PATHWAY

ERBB2 ERBB3

3.41e-0423172M18719
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_UBIQUITINATION_OF_RTK_BY_CBL

ERBB2 ERBB3

4.04e-0425172M47934
PathwayREACTOME_SIGNALING_BY_ERBB2_IN_CANCER

ERBB2 ERBB3

4.37e-0426172M29535
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB2 ERBB3

4.37e-0426172MM15501
PathwayKEGG_PATHWAYS_IN_CANCER

LAMA2 LAMB2 ERBB2 GLI1

5.20e-04325174M12868
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_SIGNALING

ERBB2 ERBB3

5.45e-0429172M27756
PathwayREACTOME_MET_ACTIVATES_PTK2_SIGNALING

LAMA2 LAMB2

5.84e-0430172M27772
PathwayREACTOME_LAMININ_INTERACTIONS

LAMA2 LAMB2

5.84e-0430172M27216
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2 FBN3

5.89e-04140173M587
PathwayWP_MAMMARY_GLAND_DEVELOPMENT_PREGNANCY_AND_LACTATION_STAGE_3_OF_4

ERBB2 ERBB3

7.07e-0433172M39455
PathwayWP_ALPHA_6_BETA_4_SIGNALING

LAMA2 LAMB2

7.07e-0433172M39503
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP3 FBN1

9.38e-0438172MM14874
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS14 SSPOP

9.88e-0439172M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS14 SSPOP

9.88e-0439172MM15165
PathwayREACTOME_MET_PROMOTES_CELL_MOTILITY

LAMA2 LAMB2

1.09e-0341172M27778
PathwayPID_ERBB2_ERBB3_PATHWAY

ERBB2 ERBB3

1.26e-0344172M175
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB2 ERBB3

1.26e-0344172MM14520
PathwayWP_FOCAL_ADHESION

LAMA2 LAMB2 ERBB2

1.36e-03187173MM15913
PathwayWP_ERBB_SIGNALING_PATHWAY

ERBB2 ERBB3

1.37e-0346172MM15950
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP3 FBN1

1.43e-0347172M646
PathwayPID_HEDGEHOG_GLI_PATHWAY

SSPOP GLI1

1.49e-0348172M219
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB2 ERBB3

1.49e-0348172MM15479
PathwayREACTOME_SIGNALING_BY_ERBB2

ERBB2 ERBB3

1.62e-0350172M553
PathwayKEGG_FOCAL_ADHESION

LAMA2 LAMB2 ERBB2

1.63e-03199173M7253
PathwayWP_FOCAL_ADHESION

LAMA2 LAMB2 ERBB2

1.63e-03199173M39402
PathwayREACTOME_SIGNALING_BY_PTK6

ERBB2 ERBB3

1.89e-0354172M29742
PathwayKEGG_MEDICUS_REFERENCE_RTK_PLCG_ITPR_SIGNALING_PATHWAY

ERBB2 ERBB3

1.96e-0355172M47952
PathwayREACTOME_NON_INTEGRIN_MEMBRANE_ECM_INTERACTIONS

LAMA2 LAMB2

2.25e-0359172M27218
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

LTBP3 FBN1

2.25e-0359172M39886
PathwayWP_CANCER_PATHWAYS

LAMA2 LAMB2 ERBB2 GLI1

2.71e-03507174M48302
PathwayWP_RAC1PAK1P38MMP2_PATHWAY

ERBB2 TIE1

2.98e-0368172M39456
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS14 SSPOP

2.98e-0368172M27303
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

LAMA2 LAMB2 ERBB2 ERBB3

3.22e-03532174M27870
PathwayREACTOME_ECM_PROTEOGLYCANS

LAMA2 LAMB2

3.70e-0376172M27219
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP3 FBN1

3.80e-0377172MM14670
PathwayREACTOME_SIGNALING_BY_MET

LAMA2 LAMB2

3.99e-0379172M27643
PathwayREACTOME_CONSTITUTIVE_SIGNALING_BY_ABERRANT_PI3K_IN_CANCER

ERBB2 ERBB3

4.40e-0383172M27163
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_PI3K_SIGNALING_PATHWAY

ERBB2 ERBB3

4.40e-0383172M47961
PathwayWP_GLIOBLASTOMA_SIGNALING

ERBB2 ERBB3

4.40e-0383172M39637
PathwayKEGG_SMALL_CELL_LUNG_CANCER

LAMA2 LAMB2

4.50e-0384172M3228
PathwayWP_EGFR_TYROSINE_KINASE_INHIBITOR_RESISTANCE

ERBB2 ERBB3

4.50e-0384172M39839
PathwayKEGG_ECM_RECEPTOR_INTERACTION

LAMA2 LAMB2

4.50e-0384172M7098
PathwayKEGG_ERBB_SIGNALING_PATHWAY

ERBB2 ERBB3

4.82e-0387172M12467
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_PI3K_SIGNALING_PATHWAY

ERBB2 ERBB3

5.04e-0389172M47963
PathwayKEGG_MEDICUS_REFERENCE_GF_RTK_RAS_ERK_SIGNALING_PATHWAY

ERBB2 ERBB3

5.38e-0392172M47927
PathwayWP_ERBB_SIGNALING

ERBB2 ERBB3

5.38e-0392172M39715
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP3 FBN1

5.61e-0394172M1041
PathwayWP_SMALL_CELL_LUNG_CANCER

LAMA2 LAMB2

5.84e-0396172M39834
PathwayWP_IL6_SIGNALING_PATHWAY

ERBB2 ERBB3

6.32e-03100172MM15826
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS14 SSPOP

7.47e-03109172MM15164
PathwayREACTOME_PI3K_AKT_SIGNALING_IN_CANCER

ERBB2 ERBB3

7.60e-03110172M27162
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS14 SSPOP

7.74e-03111172M27416
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

ERBB2 ERBB3

8.01e-03113172MM14783
PathwayREACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX

FBN1 FBN2

8.14e-03114172MM14571
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP3 FBN1

8.70e-03118172MM15588
PathwayREACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK

ERBB2 ERBB3

8.70e-03118172M713
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

FBN1 MEGF6

8.99e-03120172MM14982
PathwayREACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_TRANSPORT_AND_UPTAKE_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS

LAMB2 FBN1

9.57e-03124172M27285
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTS14 SSPOP

1.26e-02143172M27275
PathwayREACTOME_SIGNALING_BY_RECEPTOR_TYROSINE_KINASES

ERBB2 ERBB3 MEGF6

1.29e-02418173MM15587
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP3 FBN1

1.58e-02161172M27871
Pubmed

Mouse ten-m/Odz is a new family of dimeric type II transmembrane proteins expressed in many tissues.

TENM1 TENM4 TENM3 TENM2

2.88e-13427410225957
Pubmed

All four members of the Ten-m/Odz family of transmembrane proteins form dimers.

TENM1 TENM4 TENM3 TENM2

2.88e-13427412000766
Pubmed

The murine Ten-m/Odz genes show distinct but overlapping expression patterns during development and in adult brain.

TENM1 TENM4 TENM3 TENM2

1.01e-11727412915301
Pubmed

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.

LAMA2 LTBP3 FBN1 FBN2 TENM4 SSPOP

1.67e-117127633541421
Pubmed

Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25.

TENM1 TENM4 TENM3 TENM2

2.01e-11827410331952
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

TENM1 TENM4 TENM3 TENM2

6.03e-111027438713721
Pubmed

Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.

FBN1 FBN2 FBN3

1.67e-09427325034023
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

LAMA2 LAMB2 FBN1 FBN2 MEGF6 SSPOP

4.04e-0917527628071719
Pubmed

The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles.

TENM4 TENM3 TENM2

1.46e-08727310625539
Pubmed

The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration.

LAMA2 LAMB2 ERBB3

3.49e-08927319295126
Pubmed

Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.

FBN1 FBN2 MEGF6

3.49e-08927312122015
Pubmed

Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.

TENM1 TENM4 TENM3 TENM2

7.02e-085127416919471
Pubmed

Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.

FBN1 FBN2

5.80e-07227212399449
Pubmed

H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3.

ERBB2 ERBB3

5.80e-07227220581867
Pubmed

Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.

ERBB2 ERBB3

5.80e-07227235108525
Pubmed

Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer.

ERBB2 ERBB3

5.80e-07227217203234
Pubmed

Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.

FBN1 FBN2

5.80e-07227221851253
Pubmed

Correlation of Gli1 and HER2 expression in gastric cancer: Identification of novel target.

ERBB2 GLI1

5.80e-07227229321573
Pubmed

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling.

ERBB2 ERBB3

5.80e-07227222733765
Pubmed

Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.

FBN1 FBN2

5.80e-07227212429739
Pubmed

New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.

FBN1 FBN2

5.80e-07227230044367
Pubmed

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome.

LTBP3 FBN1

5.80e-07227226494287
Pubmed

Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.

FBN1 FBN2

5.80e-07227221440062
Pubmed

Zinc finger transcription factors designed for bispecific coregulation of ErbB2 and ErbB3 receptors: insights into ErbB receptor biology.

ERBB2 ERBB3

5.80e-07227216199884
Pubmed

MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.

FBN1 FBN2

5.80e-07227215131124
Pubmed

Posttranscriptional upregulation of HER3 by HER2 mRNA induces trastuzumab resistance in breast cancer.

ERBB2 ERBB3

5.80e-07227230068375
Pubmed

HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value.

ERBB2 ERBB3

5.80e-07227225739551
Pubmed

Targeting HER2/HER3 co-mutations in metastatic breast cancer: Case reports of exceptional responders to trastuzumab and pertuzumab therapy.

ERBB2 ERBB3

5.80e-07227238441358
Pubmed

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer.

ERBB2 ERBB3

5.80e-07227210205169
Pubmed

Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.

FBN1 FBN2

5.80e-07227212524050
Pubmed

In situ detection of HER2:HER2 and HER2:HER3 protein-protein interactions demonstrates prognostic significance in early breast cancer.

ERBB2 ERBB3

5.80e-07227221638049
Pubmed

Microfibril structure masks fibrillin-2 in postnatal tissues.

FBN1 FBN2

5.80e-07227220404337
Pubmed

Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu.

ERBB2 ERBB3

5.80e-07227217638894
Pubmed

The anti-HER3 antibody in combination with trastuzumab exerts synergistic antitumor activity in HER2-positive gastric cancer.

ERBB2 ERBB3

5.80e-07227227317872
Pubmed

The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation.

ERBB2 ERBB3

5.80e-07227212853564
Pubmed

LTBP3 Pathogenic Variants Predispose Individuals to Thoracic Aortic Aneurysms and Dissections.

LTBP3 FBN1

5.80e-07227229625025
Pubmed

Blood HER2 and Uromodulin as Causal Mediators of CKD.

UMOD ERBB2

5.80e-07227229511113
Pubmed

Prognostic implications of altered human epidermal growth factor receptors (HERs) in gastric carcinomas: HER2 and HER3 are predictors of poor outcome.

ERBB2 ERBB3

5.80e-07227221709195
Pubmed

Fibrillln mutations in Marfan syndrome and related phenotypes.

FBN1 FBN2

5.80e-0722728791520
Pubmed

Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors.

ERBB2 ERBB3

5.80e-07227212134143
Pubmed

Higher-order association states of cellular ERBB3 probed with photo-cross-linkable aptamers.

ERBB2 ERBB3

5.80e-07227218942860
Pubmed

Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands.

TENM4 TENM3

5.80e-07227235484136
Pubmed

The role of HER2 and HER3 in HER2-amplified cancers beyond breast cancers.

ERBB2 ERBB3

5.80e-07227233907275
Pubmed

Correlation of HER2, p95HER2 and HER3 expression and treatment outcome of lapatinib plus capecitabine in her2-positive metastatic breast cancer.

ERBB2 ERBB3

5.80e-07227222848366
Pubmed

Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.

FBN1 FBN2

5.80e-0722728120105
Pubmed

The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.

FBN1 FBN2

5.80e-07227235419902
Pubmed

A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2.

ERBB2 ERBB3

5.80e-07227218056992
Pubmed

HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer.

ERBB2 ERBB3

5.80e-07227225915155
Pubmed

Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.

FBN1 FBN2

5.80e-0722728307578
Pubmed

Fibrillin assembly: dimer formation mediated by amino-terminal sequences.

FBN1 FBN2

5.80e-07227210504303
Pubmed

Co-overexpression of HER2/HER3 is a predictor of impaired survival in breast cancer patients.

ERBB2 ERBB3

5.80e-07227225017122
Pubmed

Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.

ERBB2 ERBB3

5.80e-07227223698633
Pubmed

The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.

ERBB2 ERBB3

5.80e-07227235177646
Pubmed

Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.

FBN1 FBN3

5.80e-07227215221638
Pubmed

Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.

FBN1 FBN2

5.80e-0722727744963
Pubmed

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

ERBB2 ERBB3

5.80e-0722727538656
Pubmed

Pharmacological targeting of the pseudokinase Her3.

ERBB2 ERBB3

5.80e-07227225326665
Pubmed

Impact of HER2 codon 655 polymorphism and expression of HER2 and HER3 in non small cell lung cancer patients.

ERBB2 ERBB3

5.80e-07227226208475
Pubmed

Fibrillin microfibrils in bone physiology.

FBN1 FBN2

5.80e-07227226408953
Pubmed

Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.

FBN1 FBN2

5.80e-07227218006876
Pubmed

Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1-Mediated Lung Cancer.

ERBB2 ERBB3

5.80e-07227229959202
Pubmed

HER2 expression as a potential marker for response to therapy targeted to the EGFR.

ERBB2 ERBB3

5.80e-07227216622439
Pubmed

Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.

FBN1 FBN2

5.80e-07227224833718
Pubmed

ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival.

ERBB2 ERBB3

5.80e-07227222157714
Pubmed

Genomic profiling of pleomorphic and florid lobular carcinoma in situ reveals highly recurrent ERBB2 and ERRB3 alterations.

ERBB2 ERBB3

5.80e-07227231932682
Pubmed

Early response to ErbB2 over-expression in polarized Caco-2 cells involves partial segregation from ErbB3 by relocalization to the apical surface and initiation of survival signaling.

ERBB2 ERBB3

5.80e-07227220589763
Pubmed

Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cells.

ERBB2 ERBB3

5.80e-07227210799311
Pubmed

Spontaneous and pronase-induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines.

ERBB2 ERBB3

5.80e-07227222806884
Pubmed

Oncogenic ERBB3 mutations in human cancers.

ERBB2 ERBB3

5.80e-07227223680147
Pubmed

Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface.

ERBB2 ERBB3

5.80e-07227223843458
Pubmed

Nuclear Gli1 expression is associated with pathological complete response and event-free survival in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant therapy.

ERBB2 GLI1

5.80e-07227226526577
Pubmed

Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity.

ERBB2 ERBB3

5.80e-07227234171264
Pubmed

Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.

FBN1 FBN2

5.80e-07227224265020
Pubmed

In vivo studies of mutant fibrillin-1 microfibrils.

FBN1 FBN2

5.80e-07227220529844
Pubmed

Design, synthesis and characterization of peptidomimetic conjugate of BODIPY targeting HER2 protein extracellular domain.

ERBB2 ERBB3

5.80e-07227223688700
Pubmed

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways.

ERBB2 ERBB3

5.80e-07227222983903
Pubmed

HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models.

ERBB2 ERBB3

5.80e-07227227358485
Pubmed

Immunohistochemical expression of fibrillin-1 and fibrillin-2 during tooth development.

FBN1 FBN2

5.80e-07227225524144
Pubmed

Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase.

ERBB2 ERBB3

5.80e-07227221385943
Pubmed

CRISPR-assisted receptor deletion reveals distinct roles for ERBB2 and ERBB3 in skin keratinocytes.

ERBB2 ERBB3

5.80e-07227228805349
Pubmed

Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.

FBN1 FBN2

5.80e-07227223133647
Pubmed

Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.

ERBB2 ERBB3

5.80e-07227212000754
Pubmed

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome.

LTBP3 FBN1

5.80e-07227230306291
Pubmed

Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

ERBB2 ERBB3

5.80e-07227222248472
Pubmed

Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.

ERBB2 ERBB3

5.80e-07227212483526
Pubmed

Inhibition of ErbB-2 and ErbB-3 expression by quercetin prevents transforming growth factor alpha (TGF-alpha)- and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation.

ERBB2 ERBB3

5.80e-07227212888923
Pubmed

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

FBN1 FBN2

5.80e-07227216407178
Pubmed

Overexpression and gene amplification of EGFR, HER2, and HER3 in biliary tract carcinomas, and the possibility for therapy with the HER2-targeting antibody pertuzumab.

ERBB2 ERBB3

5.80e-07227225112701
Pubmed

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.

ERBB2 ERBB3

5.80e-07227214737100
Pubmed

Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.

FBN1 FBN2

5.80e-0722721852206
Pubmed

Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice.

ERBB2 ERBB3

5.80e-07227215731393
Pubmed

Overexpression of ErbB2 and ErbB3 receptors in Schwann cells of patients with Charcot-Marie-tooth disease type 1A.

ERBB2 ERBB3

5.80e-07227216307437
Pubmed

N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly.

FBN1 FBN2

5.80e-07227210359653
Pubmed

Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.

ERBB2 ERBB3

5.80e-07227216168116
Pubmed

Increased erbB3 promotes erbB2/neu-driven mammary tumor proliferation and co-targeting of erbB2/erbB3 receptors exhibits potent inhibitory effects on breast cancer cells.

ERBB2 ERBB3

5.80e-07227226261492
Pubmed

Mechanistic Investigations of Diarrhea Toxicity Induced by Anti-HER2/3 Combination Therapy.

ERBB2 ERBB3

5.80e-07227229654069
Pubmed

Targeting HER2 in colorectal cancer: The landscape of amplification and short variant mutations in ERBB2 and ERBB3.

ERBB2 ERBB3

5.80e-07227229338072
Pubmed

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.

ERBB2 ERBB3

5.80e-07227224678002
Pubmed

HER family receptor abnormalities in lung cancer brain metastases and corresponding primary tumors.

ERBB2 ERBB3

5.80e-07227219622585
Pubmed

Increased Expression of HER2, HER3, and HER2:HER3 Heterodimers in HPV-Positive HNSCC Using a Novel Proximity-Based Assay: Implications for Targeted Therapies.

ERBB2 ERBB3

5.80e-07227226138066
InteractionZDHHC15 interactions

LAMA2 LTBP3 FBN1 FBN2 TENM4 SSPOP

1.05e-08125266int:ZDHHC15
InteractionFBN1 interactions

LAMA2 FBN1 FBN2

3.81e-0551263int:FBN1
InteractionMFAP5 interactions

FBN1 FBN2 MEGF6

4.04e-0552263int:MFAP5
InteractionMUC4 interactions

ERBB2 ERBB3

5.73e-059262int:MUC4
InteractionMFAP2 interactions

FBN1 FBN2

1.05e-0412262int:MFAP2
InteractionMBD1 interactions

TENM1 LTBP3 MEGF6

1.31e-0477263int:MBD1
InteractionSMIM20 interactions

ERBB2 ERBB3

1.44e-0414262int:SMIM20
InteractionPIK3R2 interactions

LAMB2 ERBB2 ERBB3 LTBP3

2.03e-04230264int:PIK3R2
InteractionTMEM134 interactions

ERBB2 ERBB3

2.15e-0417262int:TMEM134
InteractionZAP70 interactions

ERBB2 ERBB3 PEAR1

2.22e-0492263int:ZAP70
InteractionLTBP1 interactions

LAMA2 FBN1 FBN2

2.22e-0492263int:LTBP1
InteractionSHD interactions

ERBB2 ERBB3

2.42e-0418262int:SHD
InteractionSYK interactions

ERBB2 ERBB3 MEGF10 PEAR1

2.83e-04251264int:SYK
InteractionSHC4 interactions

ERBB2 ERBB3

3.64e-0422262int:SHC4
InteractionATXN7 interactions

LAMB2 FBN1 MEGF6

3.65e-04109263int:ATXN7
InteractionLAMA2 interactions

LAMA2 FBN1

3.98e-0423262int:LAMA2
InteractionSOCS5 interactions

ERBB2 ERBB3

4.34e-0424262int:SOCS5
InteractionDUSP18 interactions

ERBB2 ERBB3

4.34e-0424262int:DUSP18
InteractionNTN5 interactions

FBN1 FBN2

4.34e-0424262int:NTN5
InteractionSLA2 interactions

ERBB2 ERBB3

4.34e-0424262int:SLA2
InteractionPRG2 interactions

LAMB2 LTBP3 FBN2 ADAMTS14

4.58e-04285264int:PRG2
InteractionSH2B3 interactions

ERBB2 ERBB3

4.71e-0425262int:SH2B3
InteractionHSH2D interactions

ERBB2 ERBB3

4.71e-0425262int:HSH2D
InteractionMET interactions

TENM1 ERBB2 ERBB3 TENM4

4.89e-04290264int:MET
InteractionZNF532 interactions

ERBB2 ERBB3

5.51e-0427262int:ZNF532
InteractionSTAP1 interactions

ERBB2 ERBB3

5.51e-0427262int:STAP1
InteractionTENM4 interactions

TENM1 TENM4

5.93e-0428262int:TENM4
InteractionTENM1 interactions

TENM1 TENM4

5.93e-0428262int:TENM1
InteractionSLA interactions

ERBB2 ERBB3

6.36e-0429262int:SLA
InteractionELN interactions

FBN1 FBN2

6.36e-0429262int:ELN
InteractionEGF interactions

ERBB2 ERBB3

7.27e-0431262int:EGF
InteractionSH2B1 interactions

ERBB2 ERBB3

7.75e-0432262int:SH2B1
InteractionTVP23B interactions

ERBB2 ERBB3

7.75e-0432262int:TVP23B
InteractionSH2D1B interactions

ERBB2 ERBB3

7.75e-0432262int:SH2D1B
InteractionHOXA1 interactions

LAMB2 LTBP3 FBN1 MEGF6

1.05e-03356264int:HOXA1
InteractionCNTNAP2 interactions

TENM1 TENM4 TENM2

1.08e-03158263int:CNTNAP2
InteractionPLA2G2A interactions

ERBB2 ERBB3

1.09e-0338262int:PLA2G2A
InteractionADGRE5 interactions

LTBP3 FBN1 NAGPA

1.18e-03163263int:ADGRE5
InteractionODF2L interactions

ERBB2 ERBB3

1.21e-0340262int:ODF2L
InteractionTNS1 interactions

ERBB2 ERBB3

1.27e-0341262int:TNS1
InteractionMATK interactions

ERBB2 ERBB3

1.40e-0343262int:MATK
InteractionSHC2 interactions

ERBB2 ERBB3

1.46e-0344262int:SHC2
InteractionSH2D1A interactions

ERBB2 ERBB3

1.53e-0345262int:SH2D1A
InteractionTMEM230 interactions

ERBB2 ERBB3

1.60e-0346262int:TMEM230
InteractionTMA7 interactions

ERBB2 ERBB3

1.60e-0346262int:TMA7
CytobandEnsembl 112 genes in cytogenetic band chr5q23

FBN2 MEGF10

2.17e-03117272chr5q23
GeneFamilyErb-b2 receptor tyrosine kinases

ERBB2 ERBB3

2.86e-0641321096
GeneFamilyLaminin subunits

LAMA2 LAMB2

3.14e-0512132626
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA2 LAMB2 LTBP3 FBN1 FBN2 SSPOP FBN3

9.19e-10196277M3008
CoexpressionNABA_MATRISOME

LAMA2 LAMB2 LTBP3 FBN1 FBN2 ADAMTS14 MEGF6 EGFL8 SSPOP FBN3 MEGF10

2.30e-0910262711M5889
CoexpressionNABA_CORE_MATRISOME

LAMA2 LAMB2 LTBP3 FBN1 FBN2 SSPOP FBN3

9.62e-09275277M5884
CoexpressionNABA_MATRISOME

LAMA2 LAMB2 LTBP3 FBN1 FBN2 ADAMTS14 MEGF6 EGFL8 SSPOP MEGF10

3.14e-0810082710MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

LAMA2 LAMB2 LTBP3 FBN1 FBN2 SSPOP

3.61e-08191276MM17059
CoexpressionNABA_CORE_MATRISOME

LAMA2 LAMB2 LTBP3 FBN1 FBN2 SSPOP

2.79e-07270276MM17057
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_MID_SCHWANN_CELL

LAMA2 LAMB2 ERBB2 LTBP3 EGFL8

7.23e-06268275M45796
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_MESENCHYMAL_3_CELL

FBN2 TENM4 TENM3 FBN3

2.92e-05174274M45676
CoexpressionDEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP

TENM1 LAMB2 ERBB3 FBN2 GRM6

3.32e-05368275M16431
CoexpressionDESCARTES_FETAL_HEART_SCHWANN_CELLS

ERBB3 TENM3 MEGF10

4.47e-0567273M40194
CoexpressionFRASOR_RESPONSE_TO_ESTRADIOL_DN

LAMB2 ERBB2 ERBB3

7.04e-0578273M3002
CoexpressionSENESE_HDAC1_AND_HDAC2_TARGETS_DN

LAMB2 LTBP3 TENM2 JPH3

9.87e-05238274M12004
CoexpressionINGRAM_SHH_TARGETS_UP

FBN1 FBN2 GLI1

2.85e-04125273M1320
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

ZDHHC14 LAMA2 FBN2 TENM4 TENM2

3.55e-04610275M3854
CoexpressionKINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN

LAMB2 LTBP3 FBN1 TENM2

3.73e-04337274M13206
CoexpressionHEVNER_CORTEX_CAUDAL_CORTICAL_PLATE

TENM3 TENM2

4.66e-0431272MM439
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

ZDHHC14 LAMA2 FBN2 TENM4 TENM2

4.74e-04650275MM1042
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HOPC

ERBB3 SSPOP FAM182B JPH3

5.09e-04366274M39052
CoexpressionINGRAM_SHH_TARGETS_UP

FBN1 FBN2 GLI1

5.45e-04156273MM550
CoexpressionPETRETTO_CARDIAC_HYPERTROPHY

LTBP3 FBN1

5.62e-0434272M14043
CoexpressionGYORFFY_MITOXANTRONE_RESISTANCE

LAMA2 TENM2

5.95e-0435272M1988
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

LAMA2 FBN1

5.95e-0435272M11788
CoexpressionHU_FETAL_RETINA_FIBROBLAST

LAMB2 FBN1 FBN2 PEAR1

6.16e-04385274M39264
CoexpressionCLASPER_LYMPHATIC_VESSELS_DURING_METASTASIS_DN

LAMA2 FBN1

6.30e-0436272MM1212
CoexpressionBLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP

LAMA2 FBN1 FBN2 GRM6

6.40e-04389274M6520
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HNBGABA

TENM1 TENM4 MEGF6 FAM182B JPH3

6.77e-04703275M39070
CoexpressionCASORELLI_APL_SECONDARY_VS_DE_NOVO_UP

FBN2 NAGPA

7.40e-0439272M13339
CoexpressionWONG_ADULT_TISSUE_STEM_MODULE

LAMA2 LTBP3 TENM3 TIE1 TENM2

7.58e-04721275M1999
CoexpressionNABA_BASEMENT_MEMBRANES

LAMA2 LAMB2

7.78e-0440272M5887
CoexpressionDAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN

LAMA2 ERBB2 FBN2

8.12e-04179273M8519
CoexpressionCUI_DEVELOPING_HEART_TRABECULAR_ATRIAL_CARDIOMYOCYTE

LAMB2 ERBB2 FBN2

8.12e-04179273M39308
CoexpressionDESCARTES_FETAL_INTESTINE_STROMAL_CELLS

ADAMTS14 GLI1

8.17e-0441272M40216
CoexpressionATF2_S_UP.V1_DN

LAMA2 LTBP3 TENM4

9.21e-04187273M2681
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_48H_CD4_TCELL_UP

TENM1 ERBB2 MEGF6

9.50e-04189273M4199
CoexpressionHALMOS_CEBPA_TARGETS_DN

UMOD ERBB3

9.84e-0445272M8604
CoexpressionHAY_BONE_MARROW_STROMAL

LAMB2 FBN1 TENM4 TENM2 MEGF10

1.00e-03767275M39209
CoexpressionGSE22611_NOD2_TRANSD_VS_CTRL_TRANSD_HEK293_MDP_STIM_2H_UP

ERBB2 GLI1 JPH3

1.06e-03196273M8161
CoexpressionGSE18281_CORTICAL_THYMOCYTE_VS_WHOLE_CORTEX_THYMUS_UP

ZDHHC14 UMOD ERBB2

1.06e-03196273M7238
CoexpressionGSE19923_WT_VS_E2A_KO_DP_THYMOCYTE_DN

ERBB2 PLA2G2F MEGF6

1.09e-03198273M7267
CoexpressionGSE3982_BASOPHIL_VS_NKCELL_DN

LTBP3 PLA2G2F GRM6

1.09e-03198273M5563
CoexpressionGSE41176_WT_VS_TAK1_KO_UNSTIM_BCELL_DN

TENM1 PLA2G2F TIE1

1.10e-03199273M9941
CoexpressionGSE8835_CD4_VS_CD8_TCELL_CLL_PATIENT_DN

ZDHHC14 LTBP3 TENM4

1.12e-03200273M6258
CoexpressionGSE24142_ADULT_VS_FETAL_EARLY_THYMIC_PROGENITOR_UP

ZDHHC14 ERBB3 LTBP3

1.12e-03200273M4576
CoexpressionGSE15330_HSC_VS_LYMPHOID_PRIMED_MULTIPOTENT_PROGENITOR_UP

EGFL8 TIE1 JPH3

1.12e-03200273M7018
CoexpressionGSE21380_TFH_VS_GERMINAL_CENTER_TFH_CD4_TCELL_UP

TENM4 TIE1 GLI1

1.12e-03200273M7506
CoexpressionHALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION

LAMA2 FBN1 FBN2

1.12e-03200273M5930
CoexpressionGSE41978_WT_VS_ID2_KO_KLRG1_LOW_EFFECTOR_CD8_TCELL_UP

TENM1 LAMA2 FBN1

1.12e-03200273M9553
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

LAMB2 FBN1

1.21e-0350272M1259
CoexpressionTSUNODA_CISPLATIN_RESISTANCE_DN

FBN1 FBN2

1.21e-0350272M5014
CoexpressionHEVNER_TELENCEPHALON_MENINGEAL_CELLS

LAMA2 FBN2

1.21e-0350272MM403
CoexpressionGAO_ESOPHAGUS_25W_C4_FGFR1HIGH_EPITHELIAL_CELLS

LAMA2 FBN1 TENM4

1.25e-03208273M39139
CoexpressionWU_SILENCED_BY_METHYLATION_IN_BLADDER_CANCER

LAMA2 ERBB3

1.31e-0352272M19766
CoexpressionSASAI_RESISTANCE_TO_NEOPLASTIC_TRANSFROMATION

LAMB2 FBN1

1.31e-0352272MM1118
CoexpressionSOTIRIOU_BREAST_CANCER_GRADE_1_VS_3_DN

LAMB2 LTBP3

1.36e-0353272M8077
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#1_top-relative-expression-ranked_1000

LAMA2 FBN1 FBN2 TENM4 TENM3 GLI1

1.66e-06310266gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k1_1000
CoexpressionAtlasplacenta

LAMA2 FBN1 FBN2 ADAMTS14 TENM3 TIE1

3.29e-06349266placenta
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_k-means-cluster#4_top-relative-expression-ranked_500

FBN1 FBN2 TENM4 TENM3

2.85e-05146264gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_k4_500
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4

LAMA2 LTBP3 FBN1 FBN2 TENM4 EGFL8 TENM3 GLI1

4.64e-051148268facebase_RNAseq_e14.5_palate_poster_oral_Tgfbr2_WT_2500_K4
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_k-means-cluster#3_top-relative-expression-ranked_1000

LAMA2 FBN1 TENM4 TENM3 GLI1

4.82e-05336265gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_k3_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_500

TENM4 TENM2 MEGF10

6.46e-0564263gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k4
CoexpressionAtlaskidney_P3_CapMes_Crym_k-means-cluster#4_top-relative-expression-ranked_200

FBN2 TENM4 TENM3

6.77e-0565263gudmap_kidney_P3_CapMes_Crym_k4_200
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_500

LAMA2 FBN1 TENM4 TENM3 GLI1

6.77e-05361265gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_500
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500

FBN1 FBN2 TENM4 TENM3

1.11e-04207264gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k4_500
CoexpressionAtlasStromal Cells, FRC.MLN, gp38+ CD31- CD140a+, Lymph Node, avg-5

LAMA2 LAMB2 LTBP3 FBN1 TENM3

2.24e-04466265GSM777050_500
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_top-relative-expression-ranked_1000

LAMA2 FBN1 FBN2 TENM4 TENM3 GLI1

2.72e-04768266gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_1000

LAMA2 FBN1 FBN2 TENM4 TENM3 GLI1

2.81e-04773266gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#2_top-relative-expression-ranked_1000

FBN1 FBN2 TENM4 TENM3

2.86e-04265264gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k2_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000

LAMA2 FBN1 FBN2 TENM4 TENM3 GLI1

2.89e-04777266gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlasDevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_1000

LTBP3 FBN1 FBN2 GLI1

3.92e-04288264gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_1000_k5
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#1_top-relative-expression-ranked_1000

TENM4 TENM2 MEGF10

4.16e-04120263gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k1
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k-means-cluster#3_top-relative-expression-ranked_500

FBN1 FBN2 TENM3

4.37e-04122263gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_k3_500
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle F_emap-6706_top-relative-expression-ranked_1000

TENM1 ERBB3 FBN2 TENM4 TENM2 MEGF10

4.68e-04850266gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle F_1000
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K2

LAMA2 FBN1 FBN2 TENM4 TENM3 NAGPA GLI1

4.79e-041208267facebase_RNAseq_e14.5_palate_poster_proximal_ERK2_WT_2500_K2
CoexpressionAtlasfacebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K2

LAMB2 LTBP3 FBN1 FBN2 TENM4 EGFL8 GLI1

5.29e-041228267facebase_RNAseq_e14.5_palate_poster_nasal_Tgfbr2_WT_2500_K2
CoexpressionAtlasDevelopingKidney_e11.5_ureteric bud_emap-3844_k-means-cluster#5_top-relative-expression-ranked_200

TENM1 ERBB3

6.56e-0431262gudmap_developingKidney_e11.5_ureteric bud_200_k5
CoexpressionAtlasdev gonad_e11.5_M_GonadVasMes_Flk_k-means-cluster#1_top-relative-expression-ranked_1000

FBN1 FBN2 TENM4 TENM3

7.07e-04337264gudmap_dev gonad_e11.5_M_GonadVasMes_Flk_k1_1000
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#4_top-relative-expression-ranked_500

FBN2 TENM4 TENM3

7.67e-04148263gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k4_500
CoexpressionAtlasdev gonad_e11.5_F_GonadVasMes_Flk_k-means-cluster#3_top-relative-expression-ranked_1000

FBN1 FBN2 TENM4 TENM3

8.49e-04354264gudmap_dev gonad_e11.5_F_GonadVasMes_Flk_k3_1000
CoexpressionAtlasdev gonad_e13.5_M_InterstitFLeydig_MafB_top-relative-expression-ranked_500

LAMA2 FBN1 FBN2 GLI1

8.67e-04356264gudmap_dev gonad_e13.5_M_InterstitFLeydig_MafB_500
CoexpressionAtlasdev gonad_e13.5_M_InterstitTestis_Sma_k-means-cluster#1_top-relative-expression-ranked_500

LAMA2 FBN1 GLI1

8.93e-04156263gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_k1_500
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_k-means-cluster#3_top-relative-expression-ranked_1000

LAMA2 TENM2 MEGF10

9.61e-04160263gudmap_developingKidney_e15.5_Podocyte cells_1000_k3
CoexpressionAtlasdev gonad_e12.5_M_InterstitLeydig_MafB_k-means-cluster#2_top-relative-expression-ranked_500

FBN1 TENM4 GLI1

1.05e-03165263gudmap_dev gonad_e12.5_M_InterstitLeydig_MafB_k2_500
CoexpressionAtlaskidney_P3_CapMes_Crym_top-relative-expression-ranked_200

FBN2 TENM4 TENM3

1.07e-03166263gudmap_kidney_P3_CapMes_Crym_200
CoexpressionAtlasdev gonad_e12.5_F_VasAssMesen_MafB_top-relative-expression-ranked_500

FBN1 FBN2 TENM4 TENM3

1.19e-03388264gudmap_dev gonad_e12.5_F_VasAssMesen_MafB_500
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1 TENM3 GLI1

1.58e-09193276858a186804b36d45957238d3d3eed2768b961641
ToppCelldroplet-Lung-immune-endo-depleted-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1 TENM3 GLI1

1.58e-091932767865e7ec0a288249540d4cba94ae01c93e1b617c
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN1 FBN2 TENM2 GLI1 PEAR1

1.79e-091972762cb1f557ce1400398975de94638126b4522567f3
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN1 FBN2 TENM2 GLI1 PEAR1

1.85e-091982767a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCellEndothelial-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

FBN1 TENM3 TIE1 JPH3 PEAR1

5.32e-0816927595c617143e1fbdd1d55a93ffdcc210e0be37cf2f
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LAMA2 FBN2 ADAMTS14 TENM3 MEGF10

7.70e-08182275812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating-Lymphatic_EC_differentiating_L.2.5.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZDHHC14 LAMB2 TENM3 TIE1 PEAR1

7.91e-081832754d16bfbadf2cd13008c35e23dd2b5b4ecf92ee11
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM4 TENM3 TENM2

8.35e-081852757dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1 MEGF10

8.35e-08185275785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1 MEGF10

8.35e-0818527597a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellE16.5-samps-Mesenchymal-Myofibroblast|E16.5-samps / Age Group, Lineage, Cell class and subclass

LAMA2 LTBP3 TENM4 ADAMTS14 MEGF10

8.58e-08186275e044b3428b7eacfdc72d0f57cdabaa1de04c74cd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM4 TENM3 TENM2

8.81e-081872755258674d0346e5c51a4b965efcdc1790c970845d
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 MEGF6 EGFL8 TIE1 JPH3

8.81e-08187275e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

LAMA2 LTBP3 MEGF6 GLI1 PEAR1

9.05e-08188275c90669b51e1902fe7726555290c91c92a911df83
ToppCellwk_08-11-Epithelial-PNS-intermediate_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

LAMA2 ERBB3 EGFL8 TENM3 MEGF10

9.05e-081882753f3a744b2615bf72f6119f26087099110c0d21fc
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMA2 FBN1 FBN2 TENM3 GLI1

1.00e-07192275ad48c941a3ddfd9a5146bafc2209da577bb50531
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LAMA2 FBN1 TENM4 ADAMTS14 MEGF10

1.00e-0719227567e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMA2 FBN1 FBN2 TENM3 GLI1

1.00e-0719227519b94f254d51b9bda3d9b7c6f85e27ecb58409c8
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 ERBB3 EGFL8 TENM3 MEGF10

1.03e-071932753ea6b103e35bbb276e95301999618558fa3e38b1
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 LAMB2 FBN1 TENM3 GLI1

1.03e-07193275025836c5c5a711e477c326559e618e47cae42d11
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ZDHHC14 LAMA2 FBN1 TENM4 TENM2

1.06e-0719427535f132cc38ac133be01834ed0946188aa0757eb4
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 LAMA2 FBN1 TENM4 GLI1

1.14e-0719727544673c38384453207871d3fd8e8ba9093cc06bc5
ToppCellBronchial-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN1 TENM4 TENM2 GLI1

1.14e-071972756806ec223e542f0475303698eb78c1cc527f5c6b
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LTBP3 ADAMTS14 TENM2 GLI1 PEAR1

1.20e-07199275fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_epineurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN1 TENM2 GLI1 PEAR1

1.20e-071992759c2db0bb94cba71a3cc1827844da090e213e0258
ToppCell10x5'v1-week_14-16-Mesenchymal_osteo-stroma-osteochondral_precursor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

LAMB2 LTBP3 FBN1 GLI1 MEGF10

1.23e-07200275ad3fb8ef0be45032369d1325024787fbe1dfb8d6
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 ERBB3 EGFL8 TENM3 MEGF10

1.23e-07200275363a8cebf2ace820661bcb87c7941f6671f8e5f3
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TENM1 LAMA2 FBN1 TENM4 ADAMTS14

1.23e-07200275fb53be20392a8309a7393774c774a1b1aec6e676
ToppCellCOVID-19-Heart-Adipocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

FBN1 TENM4 TENM3 MEGF10

2.12e-0615327493958bd9c951222ba5b740d1cb83fd5d78a10e1e
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LTBP3 FBN1 TENM4

3.15e-06169274849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 FBN1 FBN2 ADAMTS14

3.15e-06169274c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 FBN1 TENM3 PEAR1

3.30e-06171274972fab891135bd755d5526cbc5a963200067b0a6
ToppCellEndothelial-B-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

FBN1 TENM3 TIE1 PEAR1

3.30e-0617127407ff7059071da83da1d8f266a586573920d75b58
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 FBN1 TENM3 PEAR1

3.30e-061712742a77ed79c6f2e700e789c80451a70ecb31639719
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TENM1 ERBB3 EGFL8 TENM3

3.38e-061722748d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 ERBB3 TENM3 MEGF10

3.46e-06173274922356a5b4c84607318ac24d7caa2e235b72b066
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 FBN1 MEGF10 PEAR1

3.62e-061752741b4cefae400bf756d09ece32d3f5c0bd4c6ad73f
ToppCellwk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FBN2 ADAMTS14 TENM3 MEGF10

3.62e-06175274a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LTBP3 FBN1 TENM4

3.70e-06176274f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMB2 TIE1 JPH3 PEAR1

3.70e-061762745d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCellfacs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LTBP3 FBN1 TENM4

3.70e-06176274fee4e0f32aaf77294040c7af6c1f503571750d43
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

ZDHHC14 TENM3 TIE1 PEAR1

3.87e-06178274c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCellwk_08-11-Epithelial-PNS-Late_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ERBB3 EGFL8 TENM3 MEGF10

3.87e-06178274a7301c0bba03d10feacc02e3f929d9a9235fd25b
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM4 MEGF6 TENM3 MEGF10

4.14e-061812743aa81ac64d0cc9a74fbfa71e2176740548e7cd06
ToppCell5'-Adult-Appendix-Neuronal-Glial_mature-Adult_Glia|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM4 MEGF6 TENM3 MEGF10

4.14e-06181274997ba1be2824b00d684f2163d0114656ed11fa53
ToppCell5'-Adult-Appendix-Neuronal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TENM4 MEGF6 TENM3 MEGF10

4.14e-06181274e6b7e8dd5c13cc10ba22f2f5a8c669486f934bdc
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZDHHC14 FBN1 TIE1 PEAR1

4.23e-0618227441b070085edba7a58b81c20aa4942d06f745acf8
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZDHHC14 FBN1 TIE1 PEAR1

4.23e-061822745e9a67b2de0daa4fdc344b10a857d8a901ad810e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZDHHC14 FBN1 TIE1 PEAR1

4.23e-06182274b0fe042c71d6ab8c75abd7ba9d2de00b72d01c0c
ToppCellwk_15-18-Epithelial-PNS-Late_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

ERBB3 EGFL8 TENM3 MEGF10

4.23e-061822746462e0469224457e249d10e224082f727caa02d6
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 FBN2 TENM4 SSPOP

4.41e-06184274ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 FBN2 TENM4 SSPOP

4.41e-061842742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TENM1 FBN2 TENM4 SSPOP

4.41e-061842742b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3|TCGA-Lung / Sample_Type by Project: Shred V9

FBN2 TENM4 TENM2 MEGF10

4.41e-06184274ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCellwk_08-11-Epithelial-PNS-COL20A1+_Schwann|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ERBB3 EGFL8 TENM3 MEGF10

4.51e-06185274abec2a49fe0f0fa4cba49347207a1ee317333657
ToppCellPND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

FBN1 FBN2 TENM4 MEGF10

4.51e-06185274427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMB2 FBN1 MEGF6 EGFL8

4.51e-06185274f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 ERBB3 TENM3 MEGF10

4.51e-06185274dd17025d8c423aa0a451ac7f1f301c93528e0229
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 ERBB3 EGFL8 TENM3

4.61e-061862746f88b68735d0f7c9904eb8413e6007910d556185
ToppCell5'-Parenchyma_lung-Endothelial-Lymphatic_EC-endothelial_cell_of_lymphatic_vessel-Lymphatic_EC_differentiating|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZDHHC14 TENM3 TIE1 PEAR1

4.61e-0618627440070d9cd20188ba49b32acfca9bc16256b38bf5
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1

4.61e-0618627494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FBN1 FBN2 TENM4 TENM3

4.61e-061862744d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1

4.71e-061872744e553721fa5598cb211f44e3226280b7e6885484
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1

4.71e-06187274d36e7fc6125e7a4310499365022d38f34b757a73
ToppCelldroplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 FBN2 GLI1

4.71e-06187274827eae63fabf6892a82ce7779b5f395958d3d628
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

LAMA2 FBN1 TENM4 TENM2

4.71e-06187274bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 MEGF6 TIE1 PEAR1

4.81e-0618827426915db8863f4115b46a81982e187322e21600fd
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 MEGF6 TIE1 PEAR1

4.81e-061882743f76c0f912f8f023ea425be7f43593b3d7f967e3
ToppCellfacs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 LTBP3 FBN1 MEGF10

4.81e-06188274bba6b273bd47dd0e27fde914e9e6fc9d76fd5176
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBN1 MEGF6 TIE1 PEAR1

4.81e-0618827461ee7b152745164293d8a44ef91ee2393efbdca5
ToppCellEndothelial-B|World / lung cells shred on cell class, cell subclass, sample id

ZDHHC14 FBN1 TIE1 PEAR1

4.81e-061882745959a88728812a5f4cbfa54eddc7a73ccbaa2f68
ToppCellFibroblast-C|World / shred on cell class and cell subclass (v4)

LAMA2 FBN1 FBN2 TENM3

4.91e-0618927458e0400fbab5a0755504275aef5cf7986149abab
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 TENM3 GLI1

4.91e-061892746b3b42d758b63a0df62310c34fa3bde421c1afd7
ToppCelldroplet-Lung-LUNG-30m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 FBN1 TENM3 GLI1

4.91e-06189274344b23d3c47d0665dda1cd4856a5e72f1c28cfb3
ToppCellPND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMA2 FBN1 FBN2 GLI1

5.01e-06190274947807863a9b247c301c6cf63d6fd5a2c8018e66
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMA2 FBN1 FBN2 TENM3

5.12e-0619127475d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 FBN1 TENM3 GLI1

5.12e-0619127424dc77ee8de01b42559f92721655f4281b114e17
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LAMA2 FBN1 FBN2 TENM3

5.12e-061912744b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBN1 MEGF6 EGFL8 TIE1

5.12e-06191274b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCellfacs-Lung-nan-3m-Mesenchymal-Adventitial_Fibroblast|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LTBP3 FBN1 GLI1

5.22e-06192274a2c31390da4962bda9a936470b0b68fa1f5d47d1
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 LAMB2 FBN1 GLI1

5.22e-061922740e7e55505bd5454d7cf952a63fdcb46ec76f1973
ToppCellfacs-Lung-nan-3m-Mesenchymal-adventitial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LTBP3 FBN1 GLI1

5.22e-06192274eeab1cef7c36ae824381952c5b2c982368c379fd
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Peribronchial_fibroblasts-Peribronchial_fibroblasts_L.2.1.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LAMA2 FBN1 TENM3 GLI1

5.33e-06193274b05361ffe111a38cfa26eb86e4ae62c15ac99b7b
ToppCellTracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN2 TENM4 TENM2

5.33e-06193274549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCelldroplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 FBN1 TENM3 GLI1

5.33e-061932749d0b966d13cbce97beb43de6dc77f006c363a181
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

ZDHHC14 LAMA2 FBN1 TENM2

5.33e-06193274acad568621ed677031797b8c2e34dafea798d681
ToppCelldroplet-Limb_Muscle-nan-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1

5.33e-0619327445b5cab4dfeb0ed3b13631db5963740a792b810f
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

LAMA2 FBN1 TENM3 TENM2

5.33e-06193274ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ZDHHC14 LAMA2 FBN1 TENM2

5.44e-06194274011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellPCW_07-8.5|World / Celltypes from embryonic and fetal-stage human lung

FBN2 TENM4 TENM3 FBN3

5.44e-061942745759c83308df017f1faae248e9b85388e25254f0
ToppCellControl-Fibroblasts-Intermediate_pathological_FB|Control / group, cell type (main and fine annotations)

LAMA2 FBN1 TENM4 TENM3

5.44e-0619427403a269f75a481ea54aea8e6444605db8d6df493d
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_progenitor|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1

5.55e-0619527469a29d03e664b72f32d41876510c62345c3aed31
ToppCellfacs-GAT-Fat-3m-Mesenchymal|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1

5.55e-061952741cffae2b08dbfa1c633ce24023e89b66d28b5431
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_myofibroblast|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA2 FBN1 TENM4 TENM2

5.55e-06195274f5e91ce20a7ce528dc4c1a968c7bf096bf45c528
ToppCellfacs-Lung-3m|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 LAMB2 LTBP3 FBN1

5.55e-06195274c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCellfacs-GAT-Fat-3m-Mesenchymal-mesenchymal_stem_cell_of_adipose|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1

5.55e-061952749cef6f18664518060af7c192310dddce6d70345a
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TENM1 LAMB2 LTBP3 ADAMTS14

5.67e-06196274b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCellfacs-Lung-nan|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LAMA2 LAMB2 LTBP3 FBN1

5.67e-06196274b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell5'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA2 EGFL8 TENM3 MEGF10

5.67e-06196274e6adcfe1a00d4910e0b92848f8a80224e0d6db12
ToppCellPCW_07-8.5-Mesenchymal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LAMA2 FBN1 TENM4 TENM3

5.67e-061962748e10802f52e5e1853ea4ad34bf9a32a34e6112b5
ComputationalAdhesion molecules.

LAMA2 LAMB2 FBN1 FBN2

3.46e-05141154MODULE_122
ComputationalMetal / Ca ion binding.

UMOD FBN1 FBN2

7.56e-04133153MODULE_324
ComputationalDevelopmental processes.

LAMA2 ERBB2 FBN1 GLI1

9.42e-04333154MODULE_220
ComputationalRTK signaling.

ERBB2 TIE1

1.82e-0346152MODULE_259
ComputationalGenes in the cancer module 85.

ERBB2 TIE1

2.23e-0351152MODULE_85
ComputationalBone remodeling.

FBN1 TIE1

2.49e-0354152MODULE_234
ComputationalGenes in the cancer module 199.

ERBB2 TIE1

2.78e-0357152MODULE_199
ComputationalPlacenta genes.

LAMB2 ERBB2 ERBB3 FBN2

3.17e-03463154MODULE_38
ComputationalECM and collagens.

FBN1 TIE1 TENM2

3.42e-03225153MODULE_47
Drug2-[(1R,2R,3S,4R,5R,6S)-2-[(2R,5S)-3-[(3S,4S,5R,6S)-4,5-dihydroxy-3-(methylamino)-6-methylol-tetrahydropyran-2-yl]-4-formyl-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]oxy-5-guanidino-3,4,6-trihydroxy-cyclohexyl]guanidine

LAMA2 LAMB2 ERBB2 FBN1

2.70e-0683274CID011968896
DrugAmidopyrine [58-15-1]; Up 200; 17.2uM; MCF7; HT_HG-U133A

ZDHHC14 FBN1 MEGF6 GRM6 JPH3

3.35e-061992756818_UP
Drug2-acetamidoethanethiol

ERBB2 ERBB3

4.06e-063272ctd:C023704
DrugZD-6

ERBB2 ERBB3

2.03e-056272CID010062753
Drugfuniferine N-oxide

LTBP3 FBN1 FBN2

2.64e-0549273CID000191631
Drugdesmosine

FBN1 FBN2 FBN3

3.35e-0553273CID000025435
DrugFolfox protocol

ERBB2 ERBB3

3.78e-058272ctd:C410216
DrugPC9

ERBB2 ERBB3 GLI1

4.63e-0559273CID016040245
DrugLG 5

LAMA2 LAMB2 ERBB3

4.86e-0560273CID011840957
Drug6-(methylamino)pyrido(3,4-d)pyrimidine

ERBB2 ERBB3

6.06e-0510272ctd:C107875
DrugLY 294002; Up 200; 10uM; PC3; HT_HG-U133A

LAMA2 FBN1 MEGF6 GRM6

6.53e-051862744463_UP
DrugBM165

LAMB2 NAGPA

7.40e-0511272CID003352881
DrugAC1L1G72

LAMA2 LAMB2

7.40e-0511272CID000003553
DrugBE-23372M

ERBB2 ERBB3

7.40e-0511272CID005311105
Drug1xqc

FBN2 FBN3

7.40e-0511272CID005287617
Drug2-amino-5-methylpyridine

LAMA2 LAMB2 ERBB3

1.03e-0477273CID000015348
DrugCMF regimen

ERBB2 ERBB3

1.05e-0413272ctd:C034456
DrugNSC 714187

LAMA2 LAMB2 ERBB3

1.38e-0485273CID005288693
DrugNVP-TAE684

ERBB2 ERBB3

1.41e-0415272ctd:C516714
Drug4-anilinoquinazoline

ERBB2 ERBB3

1.61e-0416272CID000324081
DrugRgd Peptide

LAMB2 FBN1 FBN2 FBN3

1.72e-04239274CID000104802
Druggermanium monoxide

ERBB2 ERBB3 FBN2

1.74e-0492273CID006327639
Drugquinocetone

LAMA2 FBN1 FBN2 MEGF10

1.98e-04248274ctd:C502851
DrugNCI60_002052

ERBB2 ERBB3

2.54e-0420272CID006801032
DrugZD4190

ERBB2 TIE1

2.54e-0420272CID005329032
DrugNSC226080

ERBB2 ERBB3 FBN1 FBN2 FBN3 JPH3

2.57e-04782276CID000005040
DrugPrestwick_517

ERBB2 ERBB3 GLI1

2.64e-04106273CID000003804
DrugTAAD

FBN1 FBN2

2.80e-0421272CID000133445
DrugHgBr2

ERBB2 EGFL8

3.08e-0422272CID000024612
DrugAC1L1CT9

ERBB2 ERBB3

3.37e-0423272CID000002054
DrugPHA665752

ERBB2 ERBB3

3.37e-0423272CID010461815
Diseaseconnective tissue disease (implicated_via_orthology)

FBN1 FBN2 FBN3

6.83e-103273DOID:65 (implicated_via_orthology)
Diseasescoliosis (is_implicated_in)

FBN1 FBN2

4.83e-064272DOID:0060249 (is_implicated_in)
DiseaseGeleophysic dysplasia

LTBP3 FBN1

8.05e-065272C3489726
DiseaseAcromicric Dysplasia

LTBP3 FBN1

8.05e-065272C0265287
DiseaseHead and Neck Carcinoma

ERBB2 ERBB3

3.61e-0510272C3887461
Diseasecardiomyopathy (implicated_via_orthology)

ERBB2 ERBB3 JPH3

3.75e-0571273DOID:0050700 (implicated_via_orthology)
Diseasegallbladder neoplasm

ERBB2 ERBB3

4.41e-0511272C0016978
DiseaseMalignant neoplasm of gallbladder

ERBB2 ERBB3

4.41e-0511272C0153452
Diseasemedian neuropathy (biomarker_via_orthology)

ERBB2 ERBB3

7.29e-0514272DOID:571 (biomarker_via_orthology)
DiseaseBenign neoplasm of stomach

ERBB2 ERBB3

1.09e-0417272C0153943
DiseaseNeoplasm of uncertain or unknown behavior of stomach

ERBB2 ERBB3

1.09e-0417272C0496905
DiseaseCarcinoma in situ of stomach

ERBB2 ERBB3

1.09e-0417272C0154060
DiseaseChild Behaviour Checklist assessment

TENM4 TENM3

1.22e-0418272EFO_0005661
Diseaselaryngeal squamous cell carcinoma (is_marker_for)

ERBB2 ERBB3

1.37e-0419272DOID:2876 (is_marker_for)
Diseasecortical surface area measurement

LAMA2 ERBB3 FBN1 FBN2 MEGF6 TENM2 FBN3

1.60e-041345277EFO_0010736
DiseaseStomach Carcinoma

ERBB2 ERBB3

1.68e-0421272C0699791
Diseasesleep quality

LAMA2 FBN2 TENM4

1.70e-04118273EFO_0005272
DiseaseNasopharyngeal carcinoma

ERBB2 ERBB3

1.84e-0422272C2931822
Diseasestomach carcinoma (is_marker_for)

ERBB2 ERBB3

2.20e-0424272DOID:5517 (is_marker_for)
DiseasePeriodontal Pocket

ADAMTS14 TENM3

2.39e-0425272EFO_1001393
DiseaseBladder Neoplasm

LAMA2 ERBB3 GLI1

2.81e-04140273C0005695
DiseaseMalignant neoplasm of urinary bladder

LAMA2 ERBB3 GLI1

2.87e-04141273C0005684
Diseasesleep duration

LAMA2 ADAMTS14 GRM6 TENM2

3.13e-04362274EFO_0005271
DiseaseMalignant neoplasm of breast

TENM1 LAMA2 ERBB2 ERBB3 GRM6 GLI1

3.52e-041074276C0006142
Diseaseintestinal cancer (implicated_via_orthology)

ERBB2 ERBB3

3.93e-0432272DOID:10155 (implicated_via_orthology)
DiseaseHead and Neck Neoplasms

ERBB2 ERBB3

4.18e-0433272C0018671
Diseaserefractive error, self reported educational attainment

LAMA2 FBN1

4.44e-0434272EFO_0004784, MONDO_0004892
DiseaseStevens-Johnson syndrome, toxic epidermal necrolysis, response to cold medicine

LAMA2 LTBP3

5.26e-0437272EFO_0004276, EFO_0004775, EFO_0006997
Diseaseductal carcinoma in situ (is_marker_for)

ERBB2 ERBB3

5.85e-0439272DOID:0060074 (is_marker_for)
DiseaseMalignant Head and Neck Neoplasm

ERBB2 ERBB3

7.45e-0444272C0278996
Diseasemyopathy (implicated_via_orthology)

MEGF10 PEAR1

8.86e-0448272DOID:423 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CHQLCARGHCWGPGP

ERBB2

511

P04626
CHEVCKGRCWGPGSE

ERBB3

186

P21860
ECAPGWGGKHCHVDV

EGFL8

131

Q99944
CRCLPGWVGDGFECH

FBN3

1306

Q75N90
GTECAPGKWCFKGHC

ADAMTS14

526

Q8WXS8
GDHWGPHCTSRCQCK

MEGF10

141

Q96KG7
ICPLGWTGHHCLEGC

PEAR1

681

Q5VY43
LHWGDPGLQCHACDC

LAMB2

1131

P55268
IHGERKEFVCHWGGC

GLI1

261

P08151
GATGRKCDGCKHWHA

LAMA2

1551

P24043
GGRGQPKDEVDWCCH

PLA2G2F

51

Q9BZM2
GICTWGGQHCGCPAK

FAM182B

21

Q5T319
VKGVPCCWHCEACDG

GRM6

531

O15303
SECCCDGGRGWGPHC

FBN1

2361

P35555
ECCCSLGAGWGDHCE

LTBP3

941

Q9NS15
CCDGGRGWGHQCELC

FBN2

2411

P35556
DTGHWGPDCSHPCNC

MEGF6

861

O75095
CQEGQWHCGGDGGHC

SSPOP

1356

A2VEC9
WHCGGDGGHCEELVP

SSPOP

1361

A2VEC9
GWHGPGCQRPCKCEH

NAGPA

396

Q9UK23
GHCVCRHGWKGPECD

TENM1

576

Q9UKZ4
HGICVKGECHCSTGW

TENM1

636

Q9UKZ4
HGVCIGGACRCEEGW

TENM2

746

Q9NT68
VCPAGYRGDGWHCEC

UMOD

136

P07911
KECPGCLHGGVCHDH

TIE1

226

P35590
SGCVCPSGWHGVHCE

TIE1

331

P35590
GVCVRGECHCSVGWG

TENM4

671

Q6N022
HCVCQPGWRGAGCDV

TENM3

761

Q9P273
FDHHCPWVGNCVGKR

ZDHHC14

191

Q8IZN3
CGGWEDGKAHGHGVC

JPH3

16

Q8WXH2