Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sulfate adenylyltransferase (ATP) activity	PAPSS2 PAPSS1	1.51e-05	2	78	2	GO:0004781
GeneOntologyMolecularFunction	sulfate adenylyltransferase activity	PAPSS2 PAPSS1	1.51e-05	2	78	2	GO:0004779
GeneOntologyMolecularFunction	adenylylsulfate kinase activity	PAPSS2 PAPSS1	1.51e-05	2	78	2	GO:0004020
GeneOntologyMolecularFunction	5-methylcytosine dioxygenase activity	TET1 TET3	4.51e-05	3	78	2	GO:0070579
GeneOntologyMolecularFunction	glycine N-acyltransferase activity	GLYAT GLYATL1B	1.49e-04	5	78	2	GO:0047961
GeneOntologyMolecularFunction	disaccharide binding	LGALS3 LGALS9	3.12e-04	7	78	2	GO:0048030
GeneOntologyMolecularFunction	monosaccharide binding	PHYH CLEC4M LGALS3 LGALS9	5.24e-04	95	78	4	GO:0048029
GeneOntologyMolecularFunction	dioxygenase activity	PHYH IDO1 TET1 TET3	5.89e-04	98	78	4	GO:0051213
GeneOntologyMolecularFunction	vinculin binding	CORO2B TLN1	1.14e-03	13	78	2	GO:0017166
GeneOntologyMolecularFunction	carbohydrate binding	PHYH GUSB H6PD CLEC4M LGALS3 LGALS9	1.34e-03	310	78	6	GO:0030246
GeneOntologyBiologicalProcess	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	PAPSS2 PAPSS1	1.41e-05	2	78	2	GO:0050428
GeneOntologyBiologicalProcess	purine ribonucleoside bisphosphate biosynthetic process	PAPSS2 PAPSS1	1.41e-05	2	78	2	GO:0034036
GeneOntologyBiologicalProcess	regulation of vesicle-mediated transport	TBC1D4 TCP11 PROM2 ITSN1 PRKCB ROCK1 LRRTM1 REST CLEC4M LGALS3 LGALS9	4.04e-05	667	78	11	GO:0060627
Domain	APS_kinase	PAPSS2 PAPSS1	1.59e-05	2	75	2	IPR002891
Domain	Sulphate_adenylyltransferase	PAPSS2 PAPSS1	1.59e-05	2	75	2	IPR002650
Domain	ATP-Sase_PUA-like_dom	PAPSS2 PAPSS1	1.59e-05	2	75	2	IPR025980
Domain	Sulfurylase_cat_dom	PAPSS2 PAPSS1	1.59e-05	2	75	2	IPR024951
Domain	ATP-sulfurylase	PAPSS2 PAPSS1	1.59e-05	2	75	2	PF01747
Domain	PUA_2	PAPSS2 PAPSS1	1.59e-05	2	75	2	PF14306
Domain	Glc/Gal-6P_isomerase	GNPDA2 H6PD	9.50e-05	4	75	2	IPR006148
Domain	Glucosamine_iso	GNPDA2 H6PD	9.50e-05	4	75	2	PF01182
Domain	ZINC_FINGER_C2H2_2	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF839 ZNF354B ZNF415 ZNF582	2.54e-04	775	75	11	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF839 ZNF354B ZNF415 ZNF582	2.59e-04	777	75	11	PS00028
Domain	FERM_N	MYO7A TLN1 FARP2	3.11e-04	33	75	3	PF09379
Domain	FERM_N	MYO7A TLN1 FARP2	3.11e-04	33	75	3	IPR018979
Domain	Znf_C2H2-like	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF839 ZNF354B ZNF415 ZNF582	3.19e-04	796	75	11	IPR015880
Domain	Znf_C2H2	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF839 ZNF354B ZNF415 ZNF582	3.51e-04	805	75	11	IPR007087
Domain	ZnF_C2H2	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF839 ZNF354B ZNF415 ZNF582	3.62e-04	808	75	11	SM00355
Domain	-	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF354B ZNF415 ZNF582	3.71e-04	679	75	10	3.30.160.60
Domain	zf-C2H2	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF354B ZNF415 ZNF582	4.35e-04	693	75	10	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 REST ZNF354B ZNF415 ZNF582	4.40e-04	694	75	10	IPR013087
Domain	KRAB	ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 ZNF354B ZNF582	5.82e-04	358	75	7	PS50805
Domain	KRAB	ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 ZNF354B ZNF582	5.82e-04	358	75	7	PF01352
Domain	WD40	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	6.07e-04	259	75	6	PF00400
Domain	KRAB	ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 ZNF354B ZNF582	6.95e-04	369	75	7	SM00349
Domain	KRAB	ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 ZNF354B ZNF582	7.07e-04	370	75	7	IPR001909
Domain	WD40	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	7.26e-04	268	75	6	SM00320
Domain	WD40_repeat	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	7.84e-04	272	75	6	IPR001680
Domain	FERM_M	MYO7A TLN1 FARP2	8.34e-04	46	75	3	PF00373
Domain	WD_REPEATS_1	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	8.78e-04	278	75	6	PS00678
Domain	WD_REPEATS_2	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	8.95e-04	279	75	6	PS50082
Domain	WD_REPEATS_REGION	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	8.95e-04	279	75	6	PS50294
Domain	-	MYO7A TLN1 FARP2	1.00e-03	49	75	3	1.20.80.10
Domain	FERM_central	MYO7A TLN1 FARP2	1.00e-03	49	75	3	IPR019748
Domain	FERM_domain	MYO7A TLN1 FARP2	1.00e-03	49	75	3	IPR000299
Domain	FERM_1	MYO7A TLN1 FARP2	1.06e-03	50	75	3	PS00660
Domain	FERM_2	MYO7A TLN1 FARP2	1.06e-03	50	75	3	PS00661
Domain	FERM_3	MYO7A TLN1 FARP2	1.06e-03	50	75	3	PS50057
Domain	Band_41_domain	MYO7A TLN1 FARP2	1.06e-03	50	75	3	IPR019749
Domain	B41	MYO7A TLN1 FARP2	1.06e-03	50	75	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	MYO7A TLN1 FARP2	1.06e-03	50	75	3	IPR014352
Domain	WD40_repeat_dom	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	1.23e-03	297	75	6	IPR017986
Domain	PH_dom-like	TBC1D4 MYO7A ITSN1 TLN1 ROCK1 LYST FARP2	1.60e-03	426	75	7	IPR011993
Domain	Gal-bind_lectin	LGALS3 LGALS9	1.62e-03	15	75	2	PF00337
Domain	Gal-bind_lectin	LGALS3 LGALS9	1.62e-03	15	75	2	SM00908
Domain	GALECTIN	LGALS3 LGALS9	1.62e-03	15	75	2	PS51304
Domain	Galectin_CRD	LGALS3 LGALS9	1.62e-03	15	75	2	IPR001079
Domain	GLECT	LGALS3 LGALS9	1.62e-03	15	75	2	SM00276
Domain	-	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	2.20e-03	333	75	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	2.27e-03	335	75	6	IPR015943
Domain	PUA-like_domain	PAPSS2 PAPSS1	2.60e-03	19	75	2	IPR015947
Domain	FERM_CS	TLN1 FARP2	4.15e-03	24	75	2	IPR019747
Domain	-	TBC1D4 MYO7A ITSN1 TLN1 ROCK1 FARP2	4.84e-03	391	75	6	2.30.29.30
Pubmed	A member of a family of sulfate-activating enzymes causes murine brachymorphism.	PAPSS2 PAPSS1	5.09e-06	2	79	2	9671738
Pubmed	Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer.	ZNF148 APC	5.09e-06	2	79	2	27758879
Pubmed	Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia.	ZNF148 APC	5.09e-06	2	79	2	17019648
Pubmed	Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.	APC MSH2	5.09e-06	2	79	2	11507063
Pubmed	A protective role of mast cells in intestinal tumorigenesis.	APC KIT	5.09e-06	2	79	2	18258601
Pubmed	Nuclear localization of PAPS synthetase 1: a sulfate activation pathway in the nucleus of eukaryotic cells.	PAPSS2 PAPSS1	5.09e-06	2	79	2	10657990
Pubmed	Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.	PAPSS2 PAPSS1	5.09e-06	2	79	2	10679223
Pubmed	Modulation of Galectin-3 and Galectin 9 in gastric mucosa of patients with chronic gastritis and positive Helicobacter pylori infection.	LGALS3 LGALS9	5.09e-06	2	79	2	28939284
Pubmed	Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.	PAPSS2 PAPSS1	5.09e-06	2	79	2	11931637
Pubmed	Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status.	APC LYST	5.09e-06	2	79	2	9041176
Pubmed	Galectin-3 and CD117 immunocytochemistry in the diagnosis of indeterminate thyroid lesions: A pilot study.	KIT LGALS3	5.09e-06	2	79	2	34297482
Pubmed	A genetically myeloablated MPS VII model detects the expansion and curative properties of as few as 100 enriched murine stem cells.	GUSB KIT	5.09e-06	2	79	2	10560917
Pubmed	Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation.	TET1 TET3	5.09e-06	2	79	2	26711116
Pubmed	Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis.	APC MSH2	5.09e-06	2	79	2	28522752
Pubmed	Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.	PRKCB KIT	5.09e-06	2	79	2	7693453
Pubmed	Msh2 deficiency enhances somatic Apc and p53 mutations in Apc+/-Msh2-/- mice.	APC MSH2	5.09e-06	2	79	2	12584170
Pubmed	Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.	APC MSH2	5.09e-06	2	79	2	19765110
Pubmed	TET3 is recruited by REST for context-specific hydroxymethylation and induction of gene expression.	REST TET3	5.09e-06	2	79	2	25843715
Pubmed	Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.	PAPSS2 PAPSS1	5.09e-06	2	79	2	22242175
Pubmed	Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response.	APC XRCC5	5.09e-06	2	79	2	19010925
Pubmed	MSH2 deficiency contributes to accelerated APC-mediated intestinal tumorigenesis.	APC MSH2	5.09e-06	2	79	2	8674041
Pubmed	Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide.	APC LGALS3	5.09e-06	2	79	2	25031746
Pubmed	Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.	TET1 TET3	5.09e-06	2	79	2	26703470
Pubmed	Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway.	ROCK1 LGALS9	5.09e-06	2	79	2	27028892
Pubmed	Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.	TET1 TET3	5.09e-06	2	79	2	26294212
Pubmed	Galectin-3 promotes caspase-independent cell death of HIV-1-infected macrophages.	ENDOG LGALS3	5.09e-06	2	79	2	27981746
Pubmed	Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice.	APC MSH2	5.09e-06	2	79	2	10866310
Pubmed	Polyethylene glycol 8000 and colon carcinogenesis: inhibition in the F344 rat, promotion in the Min mouse.	APC MSH2	5.09e-06	2	79	2	11156379
Pubmed	Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.	THPO KIT	5.09e-06	2	79	2	27344013
Pubmed	Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.	PAPSS2 PAPSS1	5.09e-06	2	79	2	9771708
Pubmed	Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice.	IDO1 APC	5.09e-06	2	79	2	26033215
Pubmed	Very high incidence of familial colorectal cancer in Newfoundland: a comparison with Ontario and 13 other population-based studies.	APC MSH2	5.09e-06	2	79	2	17039269
Pubmed	Report of a family segregating mutations in both the APC and MSH2 genes: juvenile onset of colorectal cancer in a double heterozygote.	APC MSH2	5.09e-06	2	79	2	18629513
Pubmed	Genotype directed therapy in murine mismatch repair deficient tumors.	APC MSH2	5.09e-06	2	79	2	23935891
Pubmed	Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain.	TET1 APC TET3	6.18e-06	16	79	3	34429415
Pubmed	Induced DNA demethylation by targeting Ten-Eleven Translocation 2 to the human ICAM-1 promoter.	TET1 TET3	1.53e-05	3	79	2	24194590
Pubmed	TET proteins in malignant hematopoiesis.	TET1 TET3	1.53e-05	3	79	2	19923888
Pubmed	Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.	APC PRKCB	1.53e-05	3	79	2	19147581
Pubmed	Serum galectin 3, galectin 9 and galectin 3-binding proteins in patients with active and inactive inflammatory bowel disease.	LGALS3 LGALS9	1.53e-05	3	79	2	31019124
Pubmed	ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation.	ROCK1 YY1AP1	1.53e-05	3	79	2	35121738
Pubmed	Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.	TET1 TET3	1.53e-05	3	79	2	21778364
Pubmed	Tet family proteins and 5-hydroxymethylcytosine in development and disease.	TET1 TET3	1.53e-05	3	79	2	22569552
Pubmed	Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors.	APC MSH2	1.53e-05	3	79	2	16240453
Pubmed	RETINAL DEGENERATION IN THE MOUSE: LOCATION OF THE RD LOCUS IN LINKAGE GROUP XVII.	GUSB KIT	1.53e-05	3	79	2	14276177
Pubmed	Potential roles of galectins in myeloid differentiation into three different lineages.	LGALS3 LGALS9	1.53e-05	3	79	2	12714580
Pubmed	Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.	TET1 TET3	1.53e-05	3	79	2	23548903
Pubmed	5-Hydroxymethylcytosine-mediated active demethylation is required for mammalian neuronal differentiation and function.	TET1 TET3	1.53e-05	3	79	2	34919053
Pubmed	Reduced Expression of TET1, TET2, TET3 and TDG mRNAs Are Associated with Poor Prognosis of Patients with Early Breast Cancer.	TET1 TET3	1.53e-05	3	79	2	26207381
Pubmed	Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.	APC MSH2	1.53e-05	3	79	2	11585736
Pubmed	Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasms.	APC MSH2	1.53e-05	3	79	2	15959913
Pubmed	Effect of aging on 5-hydroxymethylcytosine in brain mitochondria.	TET1 TET3	1.53e-05	3	79	2	22445327
Pubmed	Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke.	LGALS3 LGALS9	1.53e-05	3	79	2	28112232
Pubmed	Loss of Tet enzymes compromises proper differentiation of embryonic stem cells.	TET1 TET3	1.53e-05	3	79	2	24735881
Pubmed	Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.	APC MSH2	1.53e-05	3	79	2	10992298
Pubmed	Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.	TET1 TET3	1.53e-05	3	79	2	20639862
Pubmed	Ten-Eleven Translocation Genes are Downregulated in Endometriosis.	TET1 TET3	1.53e-05	3	79	2	26917261
Pubmed	Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility.	TET1 TET3	1.53e-05	3	79	2	30130982
Pubmed	Regulation of DNA methylation signatures on NF-κB and STAT3 pathway genes and TET activity in cigarette smoke extract-challenged cells/COPD exacerbation model in vitro.	TET1 TET3	1.53e-05	3	79	2	32342329
Pubmed	Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.	TET1 TET3	1.53e-05	3	79	2	30074219
Pubmed	Infrequent occurrence of TET1, TET3, and ASXL2 mutations in myelodysplastic/myeloproliferative neoplasms.	TET1 TET3	1.53e-05	3	79	2	29531217
Pubmed	Selective targeting of TET catalytic domain promotes somatic cell reprogramming.	TET1 TET3	1.53e-05	3	79	2	32024762
Pubmed	Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs.	TET1 TET3	1.53e-05	3	79	2	27184841
Pubmed	Role of Galectins in Tumors and in Clinical Immunotherapy.	LGALS3 LGALS9	1.53e-05	3	79	2	29389859
Pubmed	TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.	TET1 APC	1.53e-05	3	79	2	36764492
Pubmed	Targeting Zfp148 activates p53 and reduces tumor initiation in the gut.	ZNF148 APC	1.53e-05	3	79	2	27487143
Pubmed	Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1.	TET1 TET3	1.53e-05	3	79	2	19372391
Pubmed	Galectin-3, Galectin-9, and Interleukin-18 Are Associated with Monocyte/Macrophage Activation and Turnover More so than Simian Immunodeficiency Virus-Associated Cardiac Pathology or Encephalitis.	LGALS3 LGALS9	1.53e-05	3	79	2	38787309
Pubmed	Gene polymorphisms of LGALS2, LGALS3 and LGALS9 in patients with rheumatoid arthritis.	LGALS3 LGALS9	1.53e-05	3	79	2	34371260
Pubmed	Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.	APC MSH2	1.53e-05	3	79	2	10602475
Pubmed	Mechanisms of TET protein-mediated DNA demethylation and its role in the regulation of mouse development.	TET1 TET3	1.53e-05	3	79	2	25608811
Pubmed	Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.	TET1 TET3	1.53e-05	3	79	2	19420352
Pubmed	Overexpression of TET dioxygenases in seminomas associates with low levels of DNA methylation and hydroxymethylation.	TET1 TET3	1.53e-05	3	79	2	28218476
Pubmed	Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.	TET1 TET3	1.53e-05	3	79	2	24958354
Pubmed	Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (Wsh) homozygotes.	KIT LYST	1.53e-05	3	79	2	3910518
Pubmed	MicroRNA-191 regulates endometrial cancer cell growth via TET1-mediated epigenetic modulation of APC.	TET1 APC	1.53e-05	3	79	2	32003827
Pubmed	One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.	TET1 TET3	1.53e-05	3	79	2	23643243
Pubmed	Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations.	APC MSH2	1.53e-05	3	79	2	23741483
Pubmed	Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.	TET1 TET3	1.53e-05	3	79	2	34879277
Pubmed	Oxygen regulation of TET enzymes.	TET1 TET3	1.53e-05	3	79	2	33410283
Pubmed	Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon.	APC MSH2	1.53e-05	3	79	2	18832169
Pubmed	Differential expression of ten-eleven translocation genes in endometrial cancers.	TET1 TET3	1.53e-05	3	79	2	28349832
Pubmed	Mouse models for hereditary nonpolyposis colorectal cancer.	APC MSH2	1.53e-05	3	79	2	9443401
Pubmed	Colorectal cancer prevention.	APC MSH2	1.53e-05	3	79	2	15375803
Pubmed	Evaluation of the immunohistochemical expression of Gal-1, Gal-3 and Gal-9 in the colon of chronic chagasic patients.	LGALS3 LGALS9	1.53e-05	3	79	2	28554765
Pubmed	Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.	TET1 MSH2 TET3	2.21e-05	24	79	3	23920106
Pubmed	Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines.	APC MSH2	3.05e-05	4	79	2	15888344
Pubmed	Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.	TET1 TET3	3.05e-05	4	79	2	21321204
Pubmed	Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells.	APC MSH2	3.05e-05	4	79	2	25036629
Pubmed	Galectin fingerprinting in naso-sinusal diseases.	LGALS3 LGALS9	3.05e-05	4	79	2	24859692
Pubmed	Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.	TET1 TET3	3.05e-05	4	79	2	31371502
Pubmed	IDO1+ Paneth cells promote immune escape of colorectal cancer.	IDO1 APC	3.05e-05	4	79	2	32444775
Pubmed	Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.	TET1 TET3	3.05e-05	4	79	2	23028748
Pubmed	Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.	TET1 TET3	3.05e-05	4	79	2	30554962
Pubmed	A galectin-specific signature in the gut delineates Crohn's disease and ulcerative colitis from other human inflammatory intestinal disorders.	LGALS3 LGALS9	3.05e-05	4	79	2	26891020
Pubmed	Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).	TET1 TET3	3.05e-05	4	79	2	25568311
Pubmed	[Expression and significance of galectin-3 and galectin-9 in mice nasal mucosa with allergic rhinitis].	LGALS3 LGALS9	3.05e-05	4	79	2	18826117
Pubmed	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer.	APC MSH2	3.05e-05	4	79	2	32286276
Pubmed	A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.	TET1 TET3	3.05e-05	4	79	2	25089631
Pubmed	The intrinsic and extrinsic effects of TET proteins during gastrulation.	TET1 TET3	3.05e-05	4	79	2	35908548
Pubmed	Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.	TET1 TET3	3.05e-05	4	79	2	35235365
GeneFamily	WD repeat domain containing	CORO2B LLGL2 DCAF8 DCAF8L1 UTP4 LYST	4.43e-05	262	45	6	362
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF148 ZNF155 ZNF517 ZNF534 ZNF528 ZNF221 ZNF354B ZNF415 ZNF582	5.73e-05	718	45	9	28
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7A TLN1 FARP2	2.60e-04	50	45	3	1293
GeneFamily	Zinc fingers CXXC-type	TET1 TET3	3.94e-04	12	45	2	136
GeneFamily	Galectins	LGALS3 LGALS9	6.23e-04	15	45	2	629
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 FARP2	1.17e-02	66	45	2	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ITSN1 ROCK1 FARP2	1.46e-02	206	45	3	682
Coexpression	GSE6259_33D1_POS_DC_VS_CD4_TCELL_DN	EVI5 MYO7A ITSN1 CPEB4 SNX18 PRKCB LGALS9	8.84e-07	176	77	7	M6757
Coexpression	GSE5589_WT_VS_IL6_KO_LPS_AND_IL6_STIM_MACROPHAGE_45MIN_UP	CEP104 ADAMTS9 GUSB PRKCB PAPSS2 KIT	2.69e-05	199	77	6	M6645
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_0.5H_BMDC_UP	TCP11 PROM2 APC PCDHB2 PRKCB H6PD	2.77e-05	200	77	6	M3957
ToppCell	(08)_Brush+PNEC-(2)_GFP_FOXI1\|(08)_Brush+PNEC / shred by cell type by condition	CCDC186 ITSN1 APC ROCK1 REST KIT	1.73e-07	138	79	6	817e3f639604ea95adae01e8685ffaa2e0aff7a8
ToppCell	T_cells-Tph_and_Tfh\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	EVI5 TBC1D4 MYO7A LYST PDE7B LGALS9	7.22e-07	176	79	6	56c055488e34605d32562571a2fee621b47c9441
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	IDO1 CCDC186 CPEB4 ROCK1 REST KIT	1.48e-06	199	79	6	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	CEP104 CCDC186 ITSN1 ROCK1 REST KIT	1.48e-06	199	79	6	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	(05)_Secretory-(2)_GFP_FOXI1\|(05)_Secretory / shred by cell type by condition	CCDC186 ITSN1 CPEB4 ROCK1 REST KIT	1.48e-06	199	79	6	d72d87e1e530ed894c0ad5e7b5b2b1d6b59fa098
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	STRADA SNX18 PRKCB PAPSS2 LYST	2.17e-05	189	79	5	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	IPF-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	STRADA SNX18 PRKCB PAPSS2 LYST	2.23e-05	190	79	5	f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCell	Control-Classical_Monocyte-cMono_2\|Classical_Monocyte / Disease condition and Cell class	PRKCB ROCK1 XRCC5 LYST LGALS3	2.65e-05	197	79	5	eb7610c9496a95a5fd866e16abcbc39b83abe617
ToppCell	Transverse-(5)_Dendritic_cell-(53)_Lymphoid_DC\|Transverse / shred on region, Cell_type, and subtype	DNHD1 IDO1 ITSN1 SNX18 ZNF354B	2.65e-05	197	79	5	15b87fd3906d7388c271d30d0c64b1bcc490801c
ToppCell	Transverse-Dendritic_cell-Lymphoid_DC\|Transverse / Region, Cell class and subclass	DNHD1 IDO1 ITSN1 SNX18 ZNF354B	2.65e-05	197	79	5	a58af0ea82f76f2a7abac1f62629ff20d552fc63
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SNX18 PAPSS2 LYST LGALS3 LGALS9	2.72e-05	198	79	5	3bc3dbd178043deadd7eef413b2761dc003abd6e
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SNX18 PAPSS2 LYST LGALS3 LGALS9	2.72e-05	198	79	5	9b47585653aaebd033c9b7bba93c7a7c35a4d60e
ToppCell	PBMC-Control-Myeloid-Non-classical_Monocyte-Non-classical_Monocyte\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	SNX18 PAPSS2 LYST LGALS3 LGALS9	2.72e-05	198	79	5	8b5d30312bbcabc6911ff03e5028766d77203dff
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	EVI5 IDO1 CCDC186 ROCK1 REST	2.72e-05	198	79	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Control-Myeloid-Non-classical_Monocyte\|Control / Disease group, lineage and cell class	SNX18 PAPSS2 LYST LGALS3 LGALS9	2.72e-05	198	79	5	ae0a51e63e2751a6d9dc0c8a3852680949173523
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	CEP104 CCDC186 CPEB4 ROCK1 REST	2.78e-05	199	79	5	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7A ITSN1 PAPSS2 LGALS3 LGALS9	2.78e-05	199	79	5	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	(06)_OLFM4+\|World / shred by cell type by condition	IDO1 CPEB4 SLC34A2 PAPSS2 KIT	2.78e-05	199	79	5	c773b9180dbfec9c19d4098dd43332e6f6050372
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MYO7A ITSN1 PAPSS2 LGALS3 LGALS9	2.78e-05	199	79	5	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	IDO1 CCDC186 ROCK1 REST KIT	2.78e-05	199	79	5	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Control-Control-Myeloid-CD16+_Monocyte\|Control / Disease, condition lineage and cell class	SNX18 PAPSS2 LYST LGALS3 LGALS9	2.85e-05	200	79	5	8dd124a5aca897652ea68efbfc5a167b4cf31aef
Drug	adenosine 5'-phosphoselenate	PAPSS2 PAPSS1	1.13e-05	2	77	2	CID000440758
Drug	AC1L1IQ4	THPO UTP4	1.13e-05	2	77	2	CID000004686
Drug	beta-methylene-APS	PAPSS2 PAPSS1	1.13e-05	2	77	2	CID000129324
Disease	Turcot syndrome (disorder)	APC MSH2	6.51e-05	5	76	2	C0265325
Disease	Adenocarcinoma of large intestine	APC PRKCB MSH2 KIT	1.13e-04	96	76	4	C1319315
Disease	Lynch Syndrome	APC MSH2	2.33e-04	9	76	2	C4552100
Disease	Nephritis	LGALS3 LGALS9	2.33e-04	9	76	2	C0027697
Disease	mismatch repair cancer syndrome (is_implicated_in)	SLC22A9 MSH2	4.25e-04	12	76	2	DOID:0112182 (is_implicated_in)
Disease	unipolar depression, cognitive function measurement	REST ZNF839	6.73e-04	15	76	2	EFO_0003761, EFO_0008354
Disease	Non-Small Cell Lung Carcinoma	MXRA5 APC SLC34A2 KIT	7.17e-04	156	76	4	C0007131
Disease	toxic shock syndrome (is_marker_for)	THPO IDO1	1.09e-03	19	76	2	DOID:14115 (is_marker_for)
Disease	liver cirrhosis (is_marker_for)	THPO CPEB4 LGALS3	1.26e-03	82	76	3	DOID:5082 (is_marker_for)
Disease	transitional cell carcinoma (is_implicated_in)	APC MSH2	1.46e-03	22	76	2	DOID:2671 (is_implicated_in)
Disease	Lynch syndrome (is_implicated_in)	SLC22A9 MSH2	1.74e-03	24	76	2	DOID:3883 (is_implicated_in)
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	APC MSH2	2.04e-03	26	76	2	C0009405
Disease	Hereditary Nonpolyposis Colorectal Cancer	APC MSH2	2.54e-03	29	76	2	C1333990
Disease	Autosomal dominant nonsyndromic hearing loss	MYO7A REST	2.54e-03	29	76	2	cv:C5779548

Protein segments in the cluster

Peptide	Gene	Start	Entry
QFPFHELFQHLLGFK	EPG5	581	Q9HCE0
EQIANFPSGNFAKHI	CCDC186	91	Q7Z3E2
FGAFVPKHFQNIQVA	CATSPER4	236	Q7RTX7
AQAPKHFHVPDQGIN	ABLIM1	506	O14639
QPQLLGSSFFEKHHV	DNHD1	1781	Q96M86
LINKHTFASLPQHFQ	ASXL3	266	Q9C0F0
PNFHFHLNLQDSLDG	PCDHB2	176	Q9Y5E7
FAFQLRNPVHNGHAL	PAPSS2	406	O95340
FKKHVELHVNPRQFN	REST	376	Q13127
QIHDHVNPKAFFSVL	IDO1	216	P14902
FQFNKTVEHGFPHQP	LLGL2	21	Q6P1M3
FAFKGNNKEQIHPHT	KIT	506	P10721
LEHNDLVKVNFAHFP	LRRTM1	216	Q86UE6
PDHFKVAVNDAHLLQ	LGALS3	206	P17931
GNHIAFHLNPRFDEN	LGALS9	261	O00182
TVFHINHGNPFNLKA	GLYAT	31	Q6IB77
HNLSFFPTVNDIKNH	CARF	461	Q8N187
LHGHEPSNLVFVNFL	DDX60L	1426	Q5H9U9
NKLFQPTHRIHGFDL	LPO	536	P22079
DHPGVNQPFLIKTNH	PDE7B	216	Q9NP56
VFPKINHGFLSADQQ	COL25A1	166	Q9BXS0
LQHFQKVIPHQFDGV	EVI5	376	O60447
ENENNGVLKKFCPHH	DCAF8	366	Q5TAQ9
HQGHFNFAAPSKKLL	GDPD4	546	Q6W3E5
HIQQVGRFKEPHAVF	PRKCB	431	P05771
FAFQLRNPVHNGHAL	PAPSS1	416	O43252
HFDGKHFNINGLLPN	ADAMTS9	656	Q9P2N4
VGQFLKLIFHQNHVN	CEP104	121	O60308
FDGIPITKNVHDNHF	CORO2B	31	Q9UQ03
HQHQRAQPGVLFFAD	B3GAT2	171	Q9NPZ5
GLALPQFFNNVSLHH	GUSB	411	P08236
AQDKLGRLFHQHQEP	ITSN1	701	Q15811
LFHINHGNPFNMEVL	GLYATL1B	31	A0A0U1RQE8
LHAFKLPALKNFQQH	LYST	596	Q99698
NNFFKHIDIDPNNAH	GNPDA2	91	Q8TDQ7
SGHDINVIQAKFFPN	DCAF8L1	236	A6NGE4
NNGALLFQNFPHHVS	CPEB4	201	Q17RY0
PGQQHCLEKILEFHQ	FARP2	191	O94887
VLEKPFGHDHFSAQQ	H6PD	171	O95479
FGIHVAELANFPKHV	MSH2	826	P43246
SLHNHSLLPQEFGFV	CFAP74	941	Q9C0B2
LHPEFHIQFLGGKSQ	TBRG4	431	Q969Z0
VFFHPLLIHGSGQNK	PHYH	256	O14832
FKHLHAFQPQSGTVE	UTP4	471	Q969X6
QGELHVSKLFNHPNI	STRADA	116	Q7RTN6
LFLDPFQIHHADVNG	SLFN14	701	P0C7P3
FGLNLHVQHLGNNVF	SLC22A9	366	Q8IVM8
QVIGKNHVAVPTHFF	ENDOG	216	Q14249
FQPHPGLQKTLEQFH	SKI	11	P12755
LVFYQHKNLNKPQHG	TET1	2046	Q8NFU7
HLKFQPHFGQQECVS	APC	1086	P25054
LFPRDFQFQQIHGHK	CLEC4M	26	Q9H2X3
HGAFQIRNLPSLKHN	C12orf29	221	Q8N999
FNLDKDVFIHQANHP	C11orf40	61	Q8WZ69
QHIFVNFHLPDLAVG	SLC34A2	351	O95436
KFVNLTHHNQQVFGP	TCP11	466	Q8WWU5
HTNHLPNGHINFKKF	RASGEF1A	396	Q8N9B8
HVLHQLKGVPEANFS	PROM2	331	Q8N271
FQCQIQFGPHNEQKH	TLN1	241	Q9Y490
QGHLANFPDIIHVQK	SNX18	526	Q96RF0
HDKAVLQGLPHFSVN	nan	51	Q6ZSV7
NFAQHQRIHTGEKPY	ZNF534	241	Q76KX8
LVFYQHKNLNQPNHG	TET3	1691	O43151
QPNPAVFIFEHKAQH	TBC1D4	111	O60343
TNFQNHKGHEFIPTL	ROCK1	1221	Q13464
LLQHQKFHTGEKPFA	ZNF517	276	Q6ZMY9
NFIQHQRVHTGEKPY	ZNF582	241	Q96NG8
LGKVCDFHLNHQQPS	ZNF839	656	A8K0R7
LHHQYNPKFQTLFQP	YY1AP1	216	Q9H869
NQPFHQDTFHFLGKE	ZNF221	71	Q9UK13
FLPHPHELQQFQAEG	ZNF415	191	Q09FC8
NFDHAPLLPQEQKAH	ZNF528	166	Q3MIS6
FRNLLSVGHQPFHQD	ZNF155	41	Q12901
GILHIHQNVESFPGK	TRMT12	331	Q53H54
LQRHVFIHTGEKPFQ	ZNF148	186	Q9UQR1
SGLFIHQKIHAQENP	ZNF354B	311	Q96LW1
HQKLNHFPGSFQIGR	TTLL4	656	Q14679
ANPQVGVAFPHIKHN	XRCC5	401	P13010
AHKDPNAIFLSFQHL	THPO	141	P40225
HNKIEFIHPQAFNGL	MXRA5	136	Q9NR99
PKNNHETQFGINHFA	MYO7A	541	Q13402