Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

HIC1 ZFHX4 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 PRDM2 TP73

1.81e-0614126517GO:0000981
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 PRDM2 TP73

2.82e-0614596517GO:0000977
GeneOntologyMolecularFunctionactin monomer binding

CORO1A LMOD2 NOS3

1.13e-0429653GO:0003785
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 PLAG1 HIC2 ZNF215 ZNF225 ZNF784 TP73

1.57e-0412446513GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 PLAG1 HIC2 ZNF215 ZNF225 ZNF784 TP73

1.95e-0412716513GO:0000987
Domain-

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

7.54e-1467965203.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

1.13e-136946520IPR013087
DomainZINC_FINGER_C2H2_2

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

8.75e-137756520PS50157
DomainZINC_FINGER_C2H2_1

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

9.17e-137776520PS00028
Domainzf-C2H2

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

1.28e-126936519PF00096
DomainZnf_C2H2-like

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

1.43e-127966520IPR015880
DomainZnf_C2H2

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

1.76e-128056520IPR007087
DomainZnF_C2H2

ZNF462 HIC1 ZFHX4 ZNF660 EGR2 ZNF648 ZNF516 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653 PRDM2

1.88e-128086520SM00355
DomainTMEM183

TMEM183A TMEM183BP

1.19e-052652IPR026509
Domainzf-C2H2_6

HIC1 ZNF660 ZNF624 ZNF225 ZNF625 ZNF791 PRDM2

1.07e-04314657PF13912
DomainZnF_U1

ZFHX4 ZFHX2 ZNF407

1.38e-0429653SM00451
DomainZnf_U1

ZFHX4 ZFHX2 ZNF407

1.38e-0429653IPR003604
DomainKRAB

ZNF747 ZNF624 ZNF215 ZNF510 ZNF225 ZNF791

1.52e-03358656PS50805
DomainKRAB

ZNF747 ZNF624 ZNF215 ZNF510 ZNF225 ZNF791

1.52e-03358656PF01352
DomainKRAB

ZNF747 ZNF624 ZNF215 ZNF510 ZNF225 ZNF791

1.77e-03369656SM00349
DomainKRAB

ZNF747 ZNF624 ZNF215 ZNF510 ZNF225 ZNF791

1.79e-03370656IPR001909
Pubmed

A census of human transcription factors: function, expression and evolution.

HIC1 ZFHX4 EGR2 ZFHX2 PLAG1 HIC2 ZNF215 THAP9 ZNF653 PRDM2 TP73

8.95e-07908651119274049
Pubmed

Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.

ZNF462 ZFHX4 LMOD2

3.43e-061665316096065
Pubmed

Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.

TMEM183A TMEM183BP

3.44e-06265216644869
Pubmed

Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1.

HIC1 HIC2

3.44e-06265211554746
Pubmed

Behavioral abnormalities observed in Zfhx2-deficient mice.

ZFHX4 ZFHX2

2.06e-05465223300874
Pubmed

The human candidate tumor suppressor gene HIC1 recruits CtBP through a degenerate GLDLSKK motif.

HIC1 HIC2

2.06e-05465212052894
Pubmed

Riz maps to distal chromosome 4 near genes involved in tumorigenesis and nerve degeneration.

CDK11B PRDM2

3.43e-0556528679000
Pubmed

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.

APPL1 LPAR1

3.43e-05565223145131
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

ZNF462 ZFHX4 ZNF516 ASCC3 GOLGA3 PRDM2

1.32e-0441865634709266
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

PPAN MDN1 ZFHX4 BMS1 CDK11B ASCC3 XAB2

1.35e-0460565728977666
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

ZNF462 MDN1 ZFHX4 ASCC3 TP73

1.88e-0428265523667531
Pubmed

The functional interactome landscape of the human histone deacetylase family.

PPAN MDN1 ZNF516 APPL1 XAB2

2.10e-0428965523752268
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

ZNF516 HIC2 ASCC3 PRDM2

3.45e-0417765426206133
Pubmed

Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.

ZNF462 GABBR2 TP73

4.45e-047965318978678
Pubmed

Interaction network of human early embryonic transcription factors.

ZNF462 ZFHX4 EGR2 ZNF516 PRDM2

5.12e-0435165538297188
Pubmed

Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.

ZNF462 ZNF747 ZNF625

5.14e-048365320562864
Pubmed

Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

HIC1 HIC2

5.76e-041965230385546
Pubmed

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

ZNF462 ZFHX4 PLAG1

6.73e-049165320546612
Pubmed

Positional cloning of the mouse saccharin preference (Sac) locus.

CDK11B TP73

7.76e-042265211555487
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

ZNF462 MDN1 ZNF516 RBM26

8.06e-0422265437071664
Pubmed

HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region.

HIC1 HIC2

8.48e-042365224748541
Pubmed

UPF2 is a critical regulator of liver development, function and regeneration.

TMEM183A TMEM183BP

9.24e-042465220657840
Pubmed

Proteomic analysis of FOXP proteins reveals interactions between cortical transcription factors associated with neurodevelopmental disorders.

ZFHX4 HIC2

1.26e-032865229365100
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

HIC1 PPAN BMS1 XAB2

1.42e-0325965430404004
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

ZNF660 CCDC82 PRPF40B EGR2 ZNF225 NOS3 ZNF653

1.58e-0391565732393512
Cytoband19p13.2

ZNF625 ZNF791 ZNF653 XAB2

3.22e-0422965419p13.2
Cytoband18q23

ZNF516 ZNF407

7.82e-042965218q23
Cytoband3q25.1

TMEM183BP ERICH6

1.01e-03336523q25.1
CytobandEnsembl 112 genes in cytogenetic band chr1p36

CDK11B PRAMEF2 RNF207 PRDM2 TP73

2.81e-03681655chr1p36
Cytoband1p36.21

PRAMEF2 PRDM2

3.65e-03636521p36.21
CytobandEnsembl 112 genes in cytogenetic band chr18q22

RTTN ZNF407

4.11e-0367652chr18q22
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF462 HIC1 ZNF660 EGR2 ZNF648 ZNF516 ZNF747 ZFHX2 ZNF624 ZNF407 PLAG1 HIC2 ZNF215 ZNF510 ZNF225 ZNF625 ZNF784 ZNF791 ZNF653

4.65e-15718471928
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZFHX4 ZFHX2

6.80e-0415472529
Diseasecarboxypeptidase Z measurement

GPR78 CPZ

2.35e-054592EFO_0801455
DiseaseRett Syndrome

EGR2 GABBR2

3.92e-055592C0035372
Diseaseautism spectrum disorder

EGR2 DOCK8 ITIH3 MPPED1

2.73e-04156594EFO_0003756
Diseaseneuroblastoma

FARS2 GPR78 CPZ

1.64e-03116593EFO_0000621
Diseaseperivascular space measurement

PDE8A LPAR1

1.65e-0330592EFO_0803382
Diseasepulse pressure measurement

HIC1 PDE8A ZFHX4 PRPF40B ZNF516 AGPAT1 CDK11B RNF207 ITIH3

1.69e-031392599EFO_0005763
DiseaseSchizophrenia

EGR2 NPSR1 GPR78 HTR3D LMOD2 LPAR1 ITIH3

1.85e-03883597C0036341

Protein segments in the cluster

PeptideGeneStartEntry
QRMARHFAIISREQT

ERICH6

351

Q7L0X2
AMVRSHRVTTFDNRT

BTNL10

111

A8MVZ5
THRRHINSAFMTFVV

ACOT11

311

Q8WXI4
MSRQVVRSSKFRHVF

CORO1A

1

P31146
EARREVSAHHRTMRE

CDK11B

206

P21127
AVQSAVRMARSFHRT

BMS1

46

Q14692
TNTSRPMYRHRVHAQ

RBM26

441

Q5T8P6
MRNFSRSDHLTTHIR

EGR2

376

P11161
RSRESTIHTAHQFLM

MDN1

5256

Q9NU22
SQDSRMTFRERTERH

NPSR1

346

Q6W5P4
RFTRQYRLTEHMRIH

HIC1

571

Q14526
ARAIHNIFRMTESHL

APPL1

531

Q9UKG1
TVLTELRFHNQRHIM

LMOD2

296

Q6P5Q4
RHITVFRMQLHTRMS

LPAR1

146

Q92633
EVSSQRRHSSMARIH

PDE8A

371

O60658
ATNTTRERRHMILHF

PFKFB3

126

Q16875
HVMAARRHQHSRLII

MPPED1

31

O15442
LSRLHREVAQVRQHM

GOLGA3

901

Q08378
HRVARRHCQRMDTVT

GPR78

196

Q96P69
MRRQTHFSTRLHTAA

LRRIQ1

1351

Q96JM4
IHVHRRKMFQATIRS

NOS3

751

P29474
ALMVTRVVNHRRFSA

PTPRT

236

O14522
RVMEAVHFRVRHTIT

TP73

581

O15350
MIHVRRHETRRNSKS

CCDC82

1

Q8N4S0
SHHSYAQMVRVLRRT

CPZ

186

Q66K79
QHVHNMDKRDSFRRT

DOCK8

996

Q8NF50
CVRVTVQARVMDRHH

C20orf27

131

Q9GZN8
RAMETLHASSRHQRI

GABBR2

371

O75899
RVRQEFEFNMTATHH

DCST2

276

Q5T1A1
RMRELGVSVHFRHVV

SLC22A14

401

Q9Y267
VFGTHTNMRRHQRRV

PRDM2

491

Q13029
TVVISSVMHRVARHA

OR52K2

256

Q8NGK3
TRQYRLTEHMRVHSG

HIC2

571

Q96JB3
MFSRNHRSRVTVARG

RTKN

1

Q9BST9
QAATHREVRAAVTRM

RTTN

1081

Q86VV8
EHIMRHTRLQRQTTE

SYT6

151

Q5T7P8
THRARMFARHDIVAL

RNF207

131

Q6ZRF8
MDQGRVTHTRRTFDR

XAB2

121

Q9HCS7
FTINVSTDMRHHRVR

TMEM183BP

316

Q1AE95
STDMRHHRVRLVFQD

TMEM183BP

321

Q1AE95
SRFAHNVVTMRAVNR

ITIH3

56

Q06033
REAFSRRHFQTLTVM

PRAMEF2

41

O60811
RMSRSFQIHHRTSFR

HTR3D

176

Q70Z44
HQVMVFVHARNATVR

ASCC3

716

Q8N3C0
TRKDVRRHMVVHTGR

PLAG1

196

Q6DJT9
TYHQMVLHSRVHRRA

ZNF516

526

Q92618
MRSSSLIIHQRIHTE

ZNF624

566

Q9P2J8
AFRTNSDFTVHLRMH

ZNF624

816

Q9P2J8
RRHMIIHSGVREFTC

ZNF653

516

Q96CK0
RSFVTHAVHDHRMTL

ZFHX4

291

Q86UP3
FISLENFRRHMITHT

ZNF791

421

Q3KP31
STLEIHMRSVLHQTR

ZFHX2

1261

Q9C0A1
FTINVSTDMRHHRVR

TMEM183A

316

Q8IXX5
STDMRHHRVRLVFQD

TMEM183A

321

Q8IXX5
ERVVRTHSRMAIFEL

THAP9

776

Q9H5L6
VVSSLRRHRMHEQQF

PPAN

121

Q9NQ55
ADRVRHSMLTVFREI

AGPAT1

251

Q99943
LVVRSTDTVFHMKRR

UBTD2

166

Q8WUN7
FMRRTALTSHLRVHT

ZNF747

246

Q9BV97
FSRSSNLTQHQRMHR

ZNF660

171

Q6AZW8
QHFLEQHERMTSTTR

PRPF40B

351

Q6NWY9
SFRSRANLNRHSMVH

ZNF225

296

Q9UK10
FNRSSSLIRHQMIHT

ZNF215

471

Q9UL58
FLTMHRRSISRHIEN

ZNF462

446

Q96JM2
YQTSVHRVRRRSHSM

ZNF510

386

Q9Y2H8
FAVASRMVEHQRVHS

ZNF648

401

Q5T619
FISRSSIRRHRIMHS

ZNF625

106

Q96I27
VTRREMTRHAATEKH

ZNF407

1056

Q9C0G0
MERTLSQREVRHIHQ

FARS2

421

O95363
RRSSDMRDHERVHTG

ZNF784

206

Q8NCA9