Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase activity	PCSK1 TMPRSS9 MST1L TMPRSS7 MMP11	4.43e-04	190	67	5	GO:0004252
GeneOntologyMolecularFunction	endopeptidase activity	PCSK1 TMPRSS9 SHH ADAMTS13 MST1L TMPRSS7 MMP11	5.84e-04	430	67	7	GO:0004175
GeneOntologyMolecularFunction	serine-type peptidase activity	PCSK1 TMPRSS9 MST1L TMPRSS7 MMP11	6.54e-04	207	67	5	GO:0008236
GeneOntologyMolecularFunction	type II transforming growth factor beta receptor binding	TGFBR3 CD44	7.16e-04	12	67	2	GO:0005114
GeneOntologyMolecularFunction	serine hydrolase activity	PCSK1 TMPRSS9 MST1L TMPRSS7 MMP11	7.28e-04	212	67	5	GO:0017171
GeneOntologyCellularComponent	mucus layer	MUC2 MUC5AC	3.21e-05	3	69	2	GO:0070701
Domain	TIL	MUC5B MUC2 SSPOP MUC5AC	6.48e-08	12	65	4	PF01826
Domain	C8	MUC5B MUC2 SSPOP MUC5AC	6.48e-08	12	65	4	PF08742
Domain	Unchr_dom_Cys-rich	MUC5B MUC2 SSPOP MUC5AC	9.33e-08	13	65	4	IPR014853
Domain	C8	MUC5B MUC2 SSPOP MUC5AC	9.33e-08	13	65	4	SM00832
Domain	TIL_dom	MUC5B MUC2 SSPOP MUC5AC	1.30e-07	14	65	4	IPR002919
Domain	VWD	MUC5B MUC2 SSPOP MUC5AC	2.36e-07	16	65	4	SM00216
Domain	VWF_type-D	MUC5B MUC2 SSPOP MUC5AC	2.36e-07	16	65	4	IPR001846
Domain	VWFD	MUC5B MUC2 SSPOP MUC5AC	2.36e-07	16	65	4	PS51233
Domain	VWD	MUC5B MUC2 SSPOP MUC5AC	2.36e-07	16	65	4	PF00094
Domain	CTCK_1	MUC5B MUC2 SSPOP MUC5AC	3.94e-07	18	65	4	PS01185
Domain	VWC_out	MUC5B MUC2 SSPOP MUC5AC	4.98e-07	19	65	4	SM00215
Domain	WxxW_domain	MUC5B MUC2 MUC5AC	7.99e-07	6	65	3	IPR025155
Domain	Mucin2_WxxW	MUC5B MUC2 MUC5AC	7.99e-07	6	65	3	PF13330
Domain	Cys_knot_C	MUC5B MUC2 SSPOP MUC5AC	1.60e-06	25	65	4	IPR006207
Domain	CTCK_2	MUC5B MUC2 SSPOP MUC5AC	1.60e-06	25	65	4	PS01225
Domain	VWFC_1	MUC5B MUC2 SSPOP MUC5AC	7.24e-06	36	65	4	PS01208
Domain	VWC	MUC5B MUC2 SSPOP MUC5AC	9.02e-06	38	65	4	SM00214
Domain	VWFC_2	MUC5B MUC2 SSPOP MUC5AC	9.02e-06	38	65	4	PS50184
Domain	VWF_dom	MUC5B MUC2 SSPOP MUC5AC	1.35e-05	42	65	4	IPR001007
Domain	LDLRA_1	TMPRSS9 PKD1 TMPRSS7 SSPOP	2.32e-05	48	65	4	PS01209
Domain	LDLRA_2	TMPRSS9 PKD1 TMPRSS7 SSPOP	2.52e-05	49	65	4	PS50068
Domain	CT	MUC5B MUC2 MUC5AC	5.91e-05	22	65	3	SM00041
Domain	HELP	EML1 EML3	1.77e-04	6	65	2	PF03451
Domain	HELP	EML1 EML3	1.77e-04	6	65	2	IPR005108
Domain	Ldl_recept_a	TMPRSS9 TMPRSS7 SSPOP	5.14e-04	45	65	3	PF00057
Domain	-	TMPRSS9 TMPRSS7 SSPOP	5.49e-04	46	65	3	4.10.400.10
Domain	LDrepeatLR_classA_rpt	TMPRSS9 TMPRSS7 SSPOP	6.61e-04	49	65	3	IPR002172
Domain	LDLa	TMPRSS9 TMPRSS7 SSPOP	6.61e-04	49	65	3	SM00192
Domain	Glyco_hormone_CN	MUC5B MUC5AC	1.22e-03	15	65	2	IPR006208
Domain	Cys_knot	MUC5B MUC5AC	1.22e-03	15	65	2	PF00007
Domain	TSP_1	ADGRB1 ADAMTS13 SSPOP	1.38e-03	63	65	3	PF00090
Domain	TSP1	ADGRB1 ADAMTS13 SSPOP	1.51e-03	65	65	3	SM00209
Domain	TSP1_rpt	ADGRB1 ADAMTS13 SSPOP	1.51e-03	65	65	3	IPR000884
Domain	TSP1	ADGRB1 ADAMTS13 SSPOP	1.51e-03	65	65	3	PS50092
Domain	-	B4GALNT4 UGP2 HAS1	2.83e-03	81	65	3	3.90.550.10
Domain	Peptidase_M10	ADAMTS13 MMP11	3.13e-03	24	65	2	PF00413
Domain	Nucleotide-diphossugar_trans	B4GALNT4 UGP2 HAS1	3.58e-03	88	65	3	IPR029044
Domain	VWC	MUC5B MUC5AC	4.25e-03	28	65	2	PF00093
Domain	Galactose-bd-like	PCSK1 PTPRK SSPOP	4.30e-03	94	65	3	IPR008979
Domain	-	FCER2 PKD1 CD44	4.70e-03	97	65	3	3.10.100.10
Domain	C-type_lectin-like/link	FCER2 PKD1 CD44	4.97e-03	99	65	3	IPR016186
Domain	CTDL_fold	FCER2 PKD1 CD44	6.17e-03	107	65	3	IPR016187
Domain	GPS	PKD1 ADGRB1	6.23e-03	34	65	2	SM00303
Domain	GPS	PKD1 ADGRB1	6.59e-03	35	65	2	PF01825
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC5B ADAMTS13 MUC2 SSPOP MUC5AC	2.15e-05	109	44	5	MM15164
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC5B MUC2 MUC5AC	3.63e-05	21	44	3	MM15706
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	MUC5B ADAMTS13 SSPOP MUC5AC	5.81e-05	68	44	4	M27303
Pathway	REACTOME_LIGAND_RECEPTOR_INTERACTIONS	BOC SHH	2.63e-04	8	44	2	M27496
Pathway	WP_HEDGEHOG_SIGNALING_WP4249	BOC SHH BCL2	3.21e-04	43	44	3	M39706
Pathway	KEGG_MEDICUS_REFERENCE_HEDGEHOG_SIGNALING_PATHWAY_PTCH_CORECEPTOR	BOC SHH	3.38e-04	9	44	2	M47893
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC5B ADAMTS13 SSPOP MUC5AC	3.88e-04	111	44	4	M27416
Pubmed	Mucin gene polymorphisms in otitis media patients.	MUC5B MUC2 MUC5AC	7.47e-09	3	69	3	19718741
Pubmed	Increased expression of MUC5AC and MUC5B promoting bacterial biofilm formation in chronic rhinosinusitis patients.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	25638393
Pubmed	Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	22269464
Pubmed	Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	23807779
Pubmed	Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	17471237
Pubmed	The mouse secreted gel-forming mucin gene cluster.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	14984930
Pubmed	Effects of the Helicobacter pylori Virulence Factor CagA and Ammonium Ion on Mucins in AGS Cells.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	29869461
Pubmed	Characterization of mouse muc6 and evidence of conservation of the gel-forming mucin gene cluster between human and mouse.	MUC5B MUC2 MUC5AC	2.99e-08	4	69	3	12676567
Pubmed	Polymorphism of human mucin genes in chest disease: possible significance of MUC2.	MUC5B MUC2 MUC5AC	7.45e-08	5	69	3	11062147
Pubmed	Differential expression of MUC genes in endometrial and cervical tissues and tumors.	MUC5B MUC2 MUC5AC	7.45e-08	5	69	3	16188033
Pubmed	Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.	MUC5B MUC2 MUC5AC	1.49e-07	6	69	3	19110483
Pubmed	Loss of Pancreas upon Activated Wnt Signaling Is Concomitant with Emergence of Gastrointestinal Identity.	SHH MUC2 MUC5AC NEUROG3	7.96e-07	36	69	4	27736991
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	SHH MUC5B MUC2 MUC5AC	1.36e-06	41	69	4	22675208
Pubmed	Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.	SHH MUC5B MUC5AC	2.68e-06	14	69	3	22797898
Pubmed	Cloning and analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5).	MUC5B MUC5AC	3.88e-06	2	69	2	7513696
Pubmed	The association between MUC5AC and MUC5B genes expression and remodeling progression in severe neutrophilic asthma: A direct relationship.	MUC5B MUC5AC	3.88e-06	2	69	2	37146737
Pubmed	MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions.	MUC5B MUC5AC	3.88e-06	2	69	2	14988081
Pubmed	Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions.	MUC5B MUC5AC	3.88e-06	2	69	2	15563276
Pubmed	The expression of MUC5AC and MUC5B mucin genes in the mucosa of chronic rhinosinusitis and nasal polyposis.	MUC5B MUC5AC	3.88e-06	2	69	2	17621824
Pubmed	Muc5b is required for airway defence.	MUC5B MUC5AC	3.88e-06	2	69	2	24317696
Pubmed	Macrophages are related to goblet cell hyperplasia and induce MUC5B but not MUC5AC in human bronchus epithelial cells.	MUC5B MUC5AC	3.88e-06	2	69	2	22391959
Pubmed	Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules.	MUC5B MUC5AC	3.88e-06	2	69	2	35776514
Pubmed	Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signaling.	SHH BCL2	3.88e-06	2	69	2	32186749
Pubmed	Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.	CD44 HAS1	3.88e-06	2	69	2	18199543
Pubmed	The ocular surface phenotype of Muc5ac and Muc5b null mice.	MUC5B MUC5AC	3.88e-06	2	69	2	24327612
Pubmed	Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes.	CD44 HAS1	3.88e-06	2	69	2	19148550
Pubmed	Gel-forming mucins form distinct morphologic structures in airways.	MUC5B MUC5AC	3.88e-06	2	69	2	28607090
Pubmed	Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat.	CD44 HAS1	3.88e-06	2	69	2	24099991
Pubmed	Mucolytic activity of bacterial and human chitinases.	MUC2 MUC5AC	3.88e-06	2	69	2	17321686
Pubmed	Muc5b is mainly expressed and sialylated in the nasal olfactory epithelium whereas Muc5ac is exclusively expressed and fucosylated in the nasal respiratory epithelium.	MUC5B MUC5AC	3.88e-06	2	69	2	31030254
Pubmed	Altered expression of MUC2 and MUC5AC in progression of colorectal carcinoma.	MUC2 MUC5AC	3.88e-06	2	69	2	20731025
Pubmed	The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium.	MUC5B MUC5AC	3.88e-06	2	69	2	23527003
Pubmed	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.	CD44 HAS1	3.88e-06	2	69	2	33908161
Pubmed	Up-regulation of MUC5AC and MUC5B mucin genes in nasopharyngeal respiratory mucosa and selective up-regulation of MUC5B in middle ear in pediatric otitis media with effusion.	MUC5B MUC5AC	3.88e-06	2	69	2	16540890
Pubmed	Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer.	CD44 HAS1	3.88e-06	2	69	2	33921242
Pubmed	Abnormalities in MUC5AC and MUC5B Protein in Airway Mucus in Asthma.	MUC5B MUC5AC	3.88e-06	2	69	2	27845589
Pubmed	No compensation in CD44 stem cell marker following BCL-2 suppression by antisense oligonucleotides.	CD44 BCL2	3.88e-06	2	69	2	23422486
Pubmed	Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.	MUC5B MUC5AC	3.88e-06	2	69	2	27435107
Pubmed	Mucins MUC5B and MUC5AC in Distal Airways and Honeycomb Spaces: Comparison among Idiopathic Pulmonary Fibrosis/Usual Interstitial Pneumonia, Fibrotic Nonspecific Interstitial Pneumonitis, and Control Lungs.	MUC5B MUC5AC	3.88e-06	2	69	2	26871672
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins.	MUC2 MUC5AC	3.88e-06	2	69	2	23832517
Pubmed	Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution.	MUC2 MUC5AC	3.88e-06	2	69	2	23832516
Pubmed	In silico cloning of mouse Muc5b gene and upregulation of its expression in mouse asthma model.	MUC5B MUC5AC	3.88e-06	2	69	2	11587997
Pubmed	Pathophysiological relevance of sputum MUC5AC and MUC5B levels in patients with mild asthma.	MUC5B MUC5AC	3.88e-06	2	69	2	34656442
Pubmed	Intestinal MUC2 and gastric M1/MUC5AC in preneoplastic lesions induced by 1,2-dimethylhydrazine in rat: a sequential analysis.	MUC2 MUC5AC	3.88e-06	2	69	2	17203232
Pubmed	Hyaluronan fragments/CD44 mediate oxidative stress-induced MUC5B up-regulation in airway epithelium.	CD44 MUC5B	3.88e-06	2	69	2	18757307
Pubmed	Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.	MUC5B MUC5AC	3.88e-06	2	69	2	34058148
Pubmed	C-Mannosylation of MUC5AC and MUC5B Cys subdomains.	MUC5B MUC5AC	3.88e-06	2	69	2	14718370
Pubmed	Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.	MUC2 MUC5AC	3.88e-06	2	69	2	12527922
Pubmed	Mucin production during prenatal and postnatal murine lung development.	MUC5B MUC5AC	3.88e-06	2	69	2	21653907
Pubmed	CD44+ cancer cells express higher levels of the anti-apoptotic protein Bcl-2 in breast tumours.	CD44 BCL2	3.88e-06	2	69	2	19385591
Pubmed	MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium.	MUC5B MUC5AC	3.88e-06	2	69	2	36427316
Pubmed	Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance.	CD44 MUC5AC	3.88e-06	2	69	2	32098629
Pubmed	Mucin deficiency causes functional and structural changes of the ocular surface.	MUC5B MUC5AC	3.88e-06	2	69	2	23272068
Pubmed	Younger patients with COME are more likely to have mucoid middle ear fluid containing mucin MUC5B.	MUC5B MUC5AC	3.88e-06	2	69	2	27729120
Pubmed	De novo NUF2 variant in a novel inherited bone marrow failure syndrome including microcephaly and renal hypoplasia.	MUC5B MUC5AC	3.88e-06	2	69	2	36111525
Pubmed	In vivo glycosylation of mucin tandem repeats.	MUC2 MUC5AC	3.88e-06	2	69	2	11445551
Pubmed	[Interleukin-1beta induces MUC2/MUC5B gene expression in human nasal epithelial cells].	MUC5B MUC2	3.88e-06	2	69	2	20873538
Pubmed	Temporal analysis of goblet cells and mucin gene expression in murine models of allergic asthma.	MUC2 MUC5AC	3.88e-06	2	69	2	14594655
Pubmed	Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.	MUC5B MUC5AC	3.88e-06	2	69	2	32348677
Pubmed	Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis.	MUC5B MUC5AC	3.88e-06	2	69	2	24332705
Pubmed	Abnormal subcellular distribution of mature MUC2 and de novo MUC5AC mucins in adenomas of the rectum: immunohistochemical detection using non-VNTR antibodies to MUC2 and MUC5AC peptide.	MUC2 MUC5AC	3.88e-06	2	69	2	12820724
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC5B MUC2 MUC5AC	5.97e-06	18	69	3	18834073
Pubmed	Loss of GATA4 causes ectopic pancreas in the stomach.	SHH MUC5AC NEUROG3	9.69e-06	21	69	3	31875961
Pubmed	Analysis of human hyaluronan synthase gene transcriptional regulation and downstream hyaluronan cell surface receptor mobility in myofibroblast differentiation.	CD44 HAS1	1.16e-05	3	69	2	25325984
Pubmed	High-Mobility Group Box 1 Upregulates MUC5AC and MUC5B Expression in Primary Airway Epithelial Cells.	MUC5B MUC5AC	1.16e-05	3	69	2	29286856
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	MUC5B MUC5AC	1.16e-05	3	69	2	36675209
Pubmed	Differences in the expression of mucins in various forms of cystitis glandularis.	MUC2 MUC5AC	1.16e-05	3	69	2	17659847
Pubmed	Th2 cytokines orchestrate the secretion of MUC5AC and MUC5B in IL-5-positive chronic rhinosinusitis with nasal polyps.	MUC5B MUC5AC	1.16e-05	3	69	2	29802623
Pubmed	Cadherin-catenin adhesion system and mucin expression: a comparison between young and older patients with gastric carcinoma.	MUC2 MUC5AC	1.16e-05	3	69	2	18825309
Pubmed	Adenomatous and foveolar gastric dysplasia: distinct patterns of mucin expression and background intestinal metaplasia.	MUC2 MUC5AC	1.16e-05	3	69	2	18300795
Pubmed	Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.	MUC5B MUC5AC	1.16e-05	3	69	2	29604272
Pubmed	Acute inflammation induces insulin-like growth factor-1 to mediate Bcl-2 and Muc5ac expression in airway epithelial cells.	BCL2 MUC5AC	1.16e-05	3	69	2	22878411
Pubmed	CD44 loss of function sensitizes AML cells to the BCL-2 inhibitor venetoclax by decreasing CXCL12-driven survival cues.	CD44 BCL2	1.16e-05	3	69	2	34115113
Pubmed	Expression of aberrant mucins in lobular carcinoma with histiocytoid feature of the breast.	MUC2 MUC5AC	1.16e-05	3	69	2	17333267
Pubmed	Aquaporin 5 expression increases mucin production in lung adenocarcinoma.	MUC5B MUC5AC	1.16e-05	3	69	2	21455588
Pubmed	Activation of Sonic Hedgehog Leads to Survival Enhancement of Astrocytes via the GRP78-Dependent Pathway in Mice Infected with Angiostrongylus cantonensis.	SHH BCL2	1.16e-05	3	69	2	25961032
Pubmed	Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue.	MUC5B MUC5AC	1.16e-05	3	69	2	20422702
Pubmed	Interleukin-33 induces mucin gene expression and goblet cell hyperplasia in human nasal epithelial cells.	MUC5B MUC5AC	1.16e-05	3	69	2	27776277
Pubmed	Autophagy of mucin granules contributes to resolution of airway mucous metaplasia.	MUC5B MUC5AC	1.16e-05	3	69	2	34158522
Pubmed	Gene expression profiling of colorectal mucinous adenocarcinomas.	MUC2 MUC5AC	1.16e-05	3	69	2	20485009
Pubmed	IL-8 regulates mucin gene expression at the posttranscriptional level in lung epithelial cells.	MUC5B MUC5AC	1.16e-05	3	69	2	19596978
Pubmed	Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.	PKD1 BCL2	1.16e-05	3	69	2	16282979
Pubmed	Regulation of neuregulin 1beta1-induced MUC5AC and MUC5B expression in human airway epithelium.	MUC5B MUC5AC	1.16e-05	3	69	2	19556605
Pubmed	Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas.	MUC2 MUC5AC	1.16e-05	3	69	2	23464473
Pubmed	Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas.	CD44 BCL2	1.16e-05	3	69	2	17464868
Pubmed	Meconium ileus in cystic fibrosis is not linked to central repetitive region length variation in MUC1, MUC2, and MUC5AC.	MUC2 MUC5AC	1.16e-05	3	69	2	24920497
Pubmed	E-cadherin is required for intestinal morphogenesis in the mouse.	CD44 MUC2 NEUROG3	1.47e-05	24	69	3	22766025
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	CD44 MUC2 MUC5AC	1.67e-05	25	69	3	34391772
Pubmed	TFAM is required for maturation of the fetal and adult intestinal epithelium.	CD44 SHH MUC2	1.88e-05	26	69	3	29684311
Pubmed	Hyaluronan-CD44 interaction promotes c-Jun signaling and miRNA21 expression leading to Bcl-2 expression and chemoresistance in breast cancer cells.	CD44 BCL2	2.32e-05	4	69	2	24606718
Pubmed	Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.	MUC2 MUC5AC	2.32e-05	4	69	2	22691042
Pubmed	Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.	MUC5B MUC5AC	2.32e-05	4	69	2	18258655
Pubmed	Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells.	MUC2 MUC5AC	2.32e-05	4	69	2	12391274
Pubmed	Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.	BOC SHH	2.32e-05	4	69	2	22445340
Pubmed	Associations between the expression of mucins (MUC1, MUC2, MUC5AC and MUC6) and clinicopathologic parameters of human breast carcinomas.	MUC2 MUC5AC	2.32e-05	4	69	2	33154304
Pubmed	ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites.	MUC5B MUC5AC	2.32e-05	4	69	2	31582416
Pubmed	Gastric mucin expression in first-degree relatives of gastric cancer patients.	MUC2 MUC5AC	2.32e-05	4	69	2	24901817
Pubmed	Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells.	SHH BCL2	2.32e-05	4	69	2	23504944
Pubmed	Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity Score (FIRS).	MUC2 MUC5AC	2.32e-05	4	69	2	36367122
Pubmed	MCP-1/CCR2B-dependent loop upregulates MUC5AC and MUC5B in human airway epithelium.	MUC5B MUC5AC	2.32e-05	4	69	2	21097527
Cytoband	11p15.5	B4GALNT4 MUC5B MUC2 MUC5AC	3.15e-05	118	69	4	11p15.5
Cytoband	3q13.2	BOC TMPRSS7	1.01e-03	31	69	2	3q13.2
GeneFamily	CD molecules\|Mucins	MUC5B MUC2 MUC5AC	1.73e-05	21	44	3	648
GeneFamily	Blood group antigens\|CD molecules\|Proteoglycans	TGFBR3 CD44	1.21e-04	7	44	2	570
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	TMPRSS9 RP1L1 ADAMTS13 NEUROG3	5.09e-06	73	69	4	51bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PTPRK DMKN ACP5 ADAMTS13 GSG1L	5.31e-06	162	69	5	2d28306c6125b31f11ea6d911a167b93a74907c5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PTPRK TSPYL2 BCL2 TNRC6C ZBED3	1.18e-05	191	69	5	696921a4f160b6b55698652488ed781e855e5e51
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TGFBR3 MOXD1 TSHZ1 ADAMTS13 MMP11	1.44e-05	199	69	5	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro-stroma\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	BOC TGFBR3 DMKN EML1 HAS1	1.47e-05	200	69	5	747c61d4e0b746278ae1f45ca4cd556c6961c76a
ToppCell	10x3'2.3-week_17-19-Mesenchymal_fibro\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	BOC TGFBR3 DMKN EML1 HAS1	1.47e-05	200	69	5	de1d193f773f4e2927baa6fc38d29754b015c6e6
Disease	cystitis (is_marker_for)	MUC2 MUC5AC	4.93e-06	2	66	2	DOID:1679 (is_marker_for)
Disease	sputum mucin-5B amount	MUC2 MUC5AC	1.48e-05	3	66	2	OBA_2050332
Disease	intestinal disease (implicated_via_orthology)	BCL2 MUC2	2.95e-05	4	66	2	DOID:5295 (implicated_via_orthology)
Disease	mucinous adenocarcinoma (is_marker_for)	MUC2 MUC5AC	4.91e-05	5	66	2	DOID:3030 (is_marker_for)
Disease	Abnormality of the face	UGP2 TET3	1.76e-04	9	66	2	C4025871
Disease	bringing up phlegm, sputum or mucus on most days, self-reported	MUC2 MUC5AC	1.76e-04	9	66	2	EFO_0009824
Disease	allergic rhinitis (biomarker_via_orthology)	BCL2 MUC5AC	2.19e-04	10	66	2	DOID:4481 (biomarker_via_orthology)
Disease	pulmonary fibrosis	MUC5B MUC5AC	2.68e-04	11	66	2	EFO_0009448
Disease	intracranial aneurysm (is_implicated_in)	PKD1 BCL2	3.21e-04	12	66	2	DOID:10941 (is_implicated_in)
Disease	Intestinal Neoplasms	BCL2 MUC2	3.21e-04	12	66	2	C0021841
Disease	Intestinal Cancer	BCL2 MUC2	3.21e-04	12	66	2	C0346627
Disease	cystic fibrosis (is_marker_for)	MUC5B MUC2 MUC5AC	3.68e-04	62	66	3	DOID:1485 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	MUC5B MUC2 MUC5AC	4.04e-04	64	66	3	DOID:4947 (is_marker_for)
Disease	gastric ulcer (implicated_via_orthology)	BCL2 MUC5AC	4.41e-04	14	66	2	DOID:10808 (implicated_via_orthology)
Disease	CD209 antigen measurement	FCER2 ADAMTS13	4.41e-04	14	66	2	EFO_0008077
Disease	pre-malignant neoplasm (biomarker_via_orthology)	SHH MUC2	6.56e-04	17	66	2	DOID:0060071 (biomarker_via_orthology)
Disease	glaucoma (is_marker_for)	MUC5AC HEPH	9.12e-04	20	66	2	DOID:1686 (is_marker_for)
Disease	transitional cell carcinoma (is_implicated_in)	CD44 BCL2	1.11e-03	22	66	2	DOID:2671 (is_implicated_in)
Disease	susceptibility to pneumonia measurement	MUC5B MUC5AC VDAC2	1.36e-03	97	66	3	EFO_0008410
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1L MUC2	1.43e-03	25	66	2	DOID:0050589 (implicated_via_orthology)
Disease	corpus callosum central volume measurement	SHH PIGO	1.79e-03	28	66	2	EFO_0010296
Disease	temporal lobe epilepsy (biomarker_via_orthology)	SHH VDAC2	2.20e-03	31	66	2	DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GGHSGGSNTWVTYPE	C2orf69	301	Q8N8R5
GPSYGGAECQGHWVE	ADGRB1	496	O14514
PPGGALYSWETGDDR	GSG1L	81	Q6UXU4
PGSAPWDYSGLDGLE	GPR25	11	O00155
SPGGASFYHWGAAVP	ADAMTS13	461	Q76LX8
SSWYNGHRPEPGLGG	MUC5B	1341	Q9HC84
VTDLTYWGPAGHGAT	NFE4	66	Q86UQ8
YWGPAGHGATAPHRS	NFE4	71	Q86UQ8
ISDYSPYGTHGGWGA	RC3H1	911	Q5TC82
PGDWGSLYSPVSQAG	NEUROG3	166	Q9Y4Z2
PDPDGDSHGPWCYTM	MST1L	436	Q2TV78
TQVAFYGSGHWDPTP	CELF2-AS1	151	Q8N7Q2
GPKGQGEYSGSWSHG	JPH1	31	Q9HDC5
GSQPDWPGGSRYDLD	JADE2	126	Q9NQC1
CTGWGDPHYVTFDGL	MUC2	4481	Q02817
VAAASGPGAWGTDHY	NDUFAF6	46	Q330K2
DGSHVDYSNWAPGEP	FCER2	236	P06734
SAWYRGQSPAGDGSP	NOL6	276	Q9H6R4
HYQPVAGSDDWGSTP	DDHD2	171	O94830
VWHGFPPGSNGDTFL	MVD	326	P53602
WFDVDFPSPGPHGGD	MUC5AC	4636	P98088
GGDWCPQHPVGAYVG	BOC	1076	Q9BWV1
GTTAYEGNWNPEAHP	CD44	351	P16070
PWVHGYPGNSAGSFG	DMKN	171	Q6E0U4
GSEGETHPWGYSSPP	BPESC1	11	Q9GZL8
YHQPWEPAAAGAVGA	HAS1	166	Q92839
GFHVFGVWPEGSDGT	EML1	726	O00423
GFHVYGVWPDGSDGT	EML3	781	Q32P44
NGICGHDGEGSPVWY	SEC14L6	86	B5MCN3
ADRYSDYGWGGPSSP	C4orf51	186	C9J302
EVGASGYGVPGPTWD	DHX9	126	Q08211
ESPHNGSGTWAYSAP	PKD1	3786	P98161
TGWPDHGVPYHATGL	PTPRK	1046	Q15262
GPQSGGDSPYAVAWA	NYNRIN	1201	Q9P2P1
RYWHGDDLPFDGPGG	MMP11	161	P24347
GEGDQPLSGYPWFHG	SH2B1	516	Q9NRF2
GSGWGDHPAEPPVAF	TNRC6C	841	Q9HCJ0
ADAPGAGATAGIHWY	SHH	421	Q15465
QGPSPQGWHAGGDAY	SSPOP	2101	A2VEC9
ADDSVPPGGSHIYNW	HEPH	151	Q9BQS7
AGIGLSNAHAAYGWP	TEX45	121	Q8NA69
SPRDPHGYWEVNGFG	B4GALNT4	951	Q76KP1
RGYEWDAGDVGAAPP	BCL2	26	P10415
LSYSGWGGSSGHDAP	ADPRH	261	P54922
SEAWGYFHLAPGRPG	ZBED3	46	Q96IU2
PIPESCSFGYHAGGW	SF3B2	656	Q13435
SGENTEAWYPPGHGD	UGP2	211	Q16851
QPEGPGGAASWEYGD	TM2D2	51	Q9BX73
GGAASWEYGDPHSPV	TM2D2	56	Q9BX73
GWDSTIESGYGEAPP	TSPYL2	96	Q9H2G4
WAIGGEGFSYPPHVG	MOXD1	276	Q6UVY6
PGPGGGSFSAYWHQL	MKRN3	431	Q13064
GVSPHNAPSAGWAGD	RP1L1	751	Q8IWN7
YHSRQGSDEWGGPAE	SAMD4B	166	Q5PRF9
SWGHGSGRPNFPGVY	TMPRSS7	811	Q7RTY8
WEGPGGEPVIYHGHT	PLCD3	386	Q8N3E9
TGVQPHEPKGHGWDY	TECPR1	1111	Q7Z6L1
VDGPENGYGHWIAST	TBC1D23	446	Q9NUY8
GVTSWGYGCGRPHFP	TMPRSS9	1026	Q7Z410
GPAIHGSAVFGYEGW	VDAC2	146	P45880
VGDWGGVPNAPFHTA	ACP5	31	P13686
APSHFTDGQWGLFPG	TET3	1481	O43151
SAAYGVGDVPGTWGP	ZNF316	271	A6NFI3
FVGFPEGHGSCTWLP	PIGO	921	Q8TEQ8
AVSGPFHYWGPVIDG	TG	2471	P01266
AQNGAPSWGGYPSIH	TSHZ1	566	Q6ZSZ6
QVPALGDSSGWPDGY	TGFBR3	526	Q03167
WTSQAHPGYGAGTGL	GEMIN4	801	P57678
LEGPIYAVGGHDGWS	KLHL1	551	Q9NR64
GAGSGVPFHWHGPGY	JMJD8	171	Q96S16
QPKAGGSGSYWPARH	MUS81	121	Q96NY9
FNPGHVDIYSASWGP	PCSK1	256	P29120