Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	perisynaptic extracellular matrix	TNC HAPLN2 NCAN	7.47e-05	11	164	3	GO:0098966
GeneOntologyCellularComponent	inhibitory synapse	MAF1 GAD1 NRXN1 IGSF9	9.74e-05	31	164	4	GO:0060077
GeneOntologyCellularComponent	synapse-associated extracellular matrix	TNC HAPLN2 NCAN	1.28e-04	13	164	3	GO:0099535
HumanPheno	Abnormal shape of the radius	GDF5 FLNA FLNB B3GALT6 LBR	3.40e-06	26	48	5	HP:0045008
HumanPheno	Radial bowing	GDF5 FLNA FLNB B3GALT6 LBR	3.40e-06	26	48	5	HP:0002986
HumanPheno	Severe short-limb dwarfism	GDF5 FLNB LBR	7.75e-06	5	48	3	HP:0008890
HumanPheno	Bowed forearm bones	GDF5 FLNA FLNB B3GALT6 LBR	1.82e-05	36	48	5	HP:0003956
HumanPheno	Abnormal morphology of the radius	GDF5 FLNA FLNB B3GALT6 LBR SLX4	3.28e-05	67	48	6	HP:0045009
HumanPheno	Bowed humerus	FLNB B3GALT6 LBR	4.26e-05	8	48	3	HP:0003865
HumanPheno	Broad phalanges of the thumb	FLNA FLNB B3GALT6	4.26e-05	8	48	3	HP:0009651
HumanPheno	Bowing of the arm	GDF5 FLNA FLNB B3GALT6 LBR	5.53e-05	45	48	5	HP:0006488
HumanPheno	Accessory carpal bones	FLNA FLNB	8.70e-05	2	48	2	HP:0004232
HumanPheno	Bipartite calcaneus	FLNA FLNB	8.70e-05	2	48	2	HP:0008127
HumanPheno	Fibular aplasia	GDF5 FLNA FLNB	1.23e-04	11	48	3	HP:0002990
HumanPheno	Pathologic fracture	MYCN ATL3 B3GALT6 ATL1 TREM2	2.05e-04	59	48	5	HP:0002756
HumanPheno	Stillbirth	GDF5 FLNA FLNB LBR	2.06e-04	32	48	4	HP:0003826
HumanPheno	Long phalanx of finger	FLNA NSD1	2.59e-04	3	48	2	HP:0006155
HumanPheno	Large joint dislocations	FLNB B3GALT6	2.59e-04	3	48	2	HP:0005008
HumanPheno	Horizontal sacrum	FLNB LBR	2.59e-04	3	48	2	HP:0003440
HumanPheno	Abnormal QRS voltage	SAA1 SVIL	2.59e-04	3	48	2	HP:0025076
HumanPheno	Short metatarsal	GDF5 FLNA FLNB IFT140 PTHLH	2.60e-04	62	48	5	HP:0010743
HumanPheno	Abnormality of temperature sensation	CACNA1A ATL3 SIM1 ATL1	2.62e-04	34	48	4	HP:0100772
HumanPheno	Impaired temperature sensation	CACNA1A ATL3 SIM1 ATL1	2.62e-04	34	48	4	HP:0010829
HumanPheno	Aplasia/Hypoplasia of the middle phalanx of the 2nd finger	MYCN GDF5 IFT140	2.66e-04	14	48	3	HP:0009568
HumanPheno	Abnormality of the middle phalanx of the 2nd finger	MYCN GDF5 IFT140	2.66e-04	14	48	3	HP:0009543
HumanPheno	Skeletal dysplasia	GDF5 FLNA FLNB IFT140 ACP5 B3GALT6 LBR TREM2	2.93e-04	186	48	8	HP:0002652
HumanPheno	Aplasia/Hypoplasia of metatarsal bones	GDF5 FLNA FLNB IFT140 PTHLH	3.49e-04	66	48	5	HP:0001964
HumanPheno	Abnormality of the humerus	GDF5 FLNA FLNB B3GALT6 LBR	4.01e-04	68	48	5	HP:0003063
HumanPheno	Sclerosis of skull base	FLNA ACP5 LBR	4.04e-04	16	48	3	HP:0002694
HumanPheno	Aplasia/Hypoplasia of the phalanges of the 2nd finger	MYCN GDF5 IFT140	4.04e-04	16	48	3	HP:0009552
HumanPheno	Short phalanx of finger	MYCN GDF5 FLNA FLNB IFT140 ACP5 NSD1 B3GALT6 LBR PTHLH	4.47e-04	306	48	10	HP:0009803
HumanPheno	Abnormal pancreas morphology	MYCN FLNB IFT140 GATA6 XPNPEP3 ZMYM3	4.47e-04	107	48	6	HP:0012090
HumanPheno	Carpal synostosis	GDF5 FLNA FLNB B3GALT6	4.48e-04	39	48	4	HP:0009702
HumanPheno	Abnormal hand bone ossification	GDF5 FLNA FLNB ATL3 B3GALT6	4.59e-04	70	48	5	HP:0010660
HumanPheno	Abnormal humerus morphology	FLNB B3GALT6 LBR	4.87e-04	17	48	3	HP:0031095
HumanPheno	Mixed hearing impairment	FLNA FLNB B3GALT6 CDK5RAP2	4.95e-04	40	48	4	HP:0000410
HumanPheno	Short 3rd metacarpal	FLNA LBR	5.15e-04	4	48	2	HP:0010041
HumanPheno	Impaired ability to dress oneself	ATL3 ATL1	5.15e-04	4	48	2	HP:0031060
HumanPheno	Spatulate thumbs	FLNB B3GALT6	5.15e-04	4	48	2	HP:0001222
HumanPheno	Hypoplastic iliac body	FLNB B3GALT6	5.15e-04	4	48	2	HP:0008824
HumanPheno	Cardiac amyloidosis	GSN SAA1	5.15e-04	4	48	2	HP:0030843
HumanPheno	Abnormality of the phalanges of the 2nd finger	MYCN GDF5 IFT140	5.80e-04	18	48	3	HP:0009541
HumanPheno	Aplasia/hypoplasia of the femur	GDF5 FLNB IFT140 B3GALT6 LBR	5.94e-04	74	48	5	HP:0005613
HumanPheno	Prominent forehead	MYCN FLNA FLNB IFT140 HECTD4 NSD1 B3GALT6 LBR PIK3R1	6.10e-04	261	48	9	HP:0011220
HumanPheno	Aplasia/Hypoplasia of the phalanges of the hand	MYCN GDF5 FLNA FLNB IFT140 ACP5 NSD1 B3GALT6 LBR PTHLH	6.21e-04	319	48	10	HP:0009767
HumanPheno	Abnormal metatarsal morphology	GDF5 FLNA FLNB IFT140 ATL3 B3GALT6 PTHLH	6.34e-04	159	48	7	HP:0001832
HumanPheno	Abnormal 2nd finger morphology	MYCN GDF5 FLNA IFT140	6.54e-04	43	48	4	HP:0004100
HumanPheno	Aplasia/Hypoplasia of the 2nd finger	MYCN GDF5 IFT140	6.85e-04	19	48	3	HP:0006264
HumanPheno	Short limb dwarfism	GDF5 FLNB LBR	6.85e-04	19	48	3	HP:0003505
HumanPheno	Neonatal death	GDF5 GAD1 FLNA FLNB LBR TARS2	6.89e-04	116	48	6	HP:0003811
HumanPheno	Triangular shaped phalanges of the hand	MYCN GDF5 FLNA FLNB IFT140 NSD1 B3GALT6 SLX4	7.51e-04	214	48	8	HP:0009774
HumanPheno	Frontal bossing	CACNA1A FLNA FLNB IFT140 ACP5 BCORL1 HECTD4 GATA6 NSD1 B3GALT6 LBR SIM1 PTHLH PIK3R1 SUPT16H SLX4	7.70e-04	738	48	16	HP:0002007
HumanPheno	Deviation of the 2nd finger	GDF5 FLNA IFT140	8.00e-04	20	48	3	HP:0009468
HumanPheno	Abnormal shape of the frontal region	CACNA1A FLNA FLNB IFT140 ACP5 BCORL1 HECTD4 GATA6 NSD1 B3GALT6 LBR SIM1 PTHLH PIK3R1 SUPT16H SLX4	8.06e-04	741	48	16	HP:0011218
HumanPheno	Abnormal frontal bone morphology	CACNA1A FLNA FLNB IFT140 ACP5 BCORL1 HECTD4 GATA6 NSD1 B3GALT6 LBR SIM1 PTHLH PIK3R1 SUPT16H SLX4	8.19e-04	742	48	16	HP:0430000
HumanPheno	Aplasia/Hypoplasia of the 3rd metacarpal	FLNA LBR	8.54e-04	5	48	2	HP:0010039
HumanPheno	Abnormal 3rd metacarpal morphology	FLNA LBR	8.54e-04	5	48	2	HP:0010011
HumanPheno	EMG: slow motor conduction	ATL3 ATL1	8.54e-04	5	48	2	HP:0100287
HumanPheno	Trophic changes related to pain	ATL3 ATL1	8.54e-04	5	48	2	HP:0010834
HumanPheno	Abnormality of the upper arm	GDF5 FLNA FLNB B3GALT6 LBR	9.00e-04	81	48	5	HP:0001454
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FLNA GBF1 NOB1 HECTD4 APBB3 NSD1 DGKQ ANKHD1 TEP1 EML3 CABLES1 TYK2 CNPPD1 TNRC18 AATK FAM83F PROM2 EXOSC6 SEC16A NLE1 TNK2 TNKS1BP1 ATG9A ZNF324B	6.44e-10	1105	166	24	35748872
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNA FLNB L3MBTL2 NSD1 TNRC18 NFKB1 SVIL EXOSC6 SUPT16H SEC16A TNKS1BP1 MTCL1	7.69e-08	332	166	12	37433992
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	EML4 TNIP2 CABLES1 TYK2 AATK NDC80 NFKB1 SVIL SUPT16H SEC16A MTCL1 SLX4	5.79e-07	401	166	12	25852190
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CACNA1A NHSL2 DLGAP4 HECTD4 NSD1 DBN1 ARMCX4 LMTK3 GSN NRXN1 UBR5 NCAN SVIL SUPT16H SEC16A CDK5RAP2 CCAR2 MTCL1	9.21e-07	963	166	18	28671696
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	WASHC2C L3MBTL2 KIF24 HNRNPAB EML3 ZNF106 NDC80 UBR5 SVIL ZNF324 CDK5RAP2 CCAR2 TNKS1BP1 MTCL1 DCAF11 CCDC9 SLX4 ZMYM3 CREB3L2	2.95e-06	1155	166	19	20360068
Pubmed	A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.	FLNA TNIP2 ANKHD1 NFKB1 XPNPEP3 SEC16A CCAR2	1.36e-05	162	166	7	14743216
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	TARS2 ANKHD1 UBR5 SEC16A CCAR2 DCAF11	1.38e-05	108	166	6	30166453
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNA FLNB GRWD1 L3MBTL2 DBN1 HNRNPAB XPNPEP3 EXOSC6 SEC16A CCAR2 SPINDOC CCDC9	1.48e-05	551	166	12	34728620
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	FLNA FLNB GRWD1 EML4 PRSS56 NOB1 ANKHD1 HNRNPAB GSN UBR5 SBNO1 MDC1 XPNPEP3 EXOSC6 SUPT16H SEC16A SCO1 CCAR2 TNKS1BP1 MTCL1	1.49e-05	1415	166	20	28515276
Pubmed	GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts.	TNC GATA6	2.26e-05	2	166	2	18177748
Pubmed	The ANK repeats of Notch-4/Int3 activate NF-κB canonical pathway in the absence of Rbpj and causes mammary tumorigenesis.	NFKB1 NOTCH4	2.26e-05	2	166	2	29057904
Pubmed	Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit.	GAD1 NRXN1	2.26e-05	2	166	2	32684634
Pubmed	Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis.	CASP1 TREM2	2.26e-05	2	166	2	29887864
Pubmed	Urokinase stimulates human vascular smooth muscle cell migration via a phosphatidylinositol 3-kinase-Tyk2 interaction.	TYK2 PIK3R1	2.26e-05	2	166	2	10995743
Pubmed	Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome.	FLNA FLNB	2.26e-05	2	166	2	17635842
Pubmed	TNFAIP3 interacting protein 2 relieves lipopolysaccharide (LPS)-induced inflammatory injury in endometritis by inhibiting NF-kappaB activation.	TNIP2 NFKB1	2.26e-05	2	166	2	37904691
Pubmed	Mapping of a defined neurocan binding site to distinct domains of tenascin-C.	TNC NCAN	2.26e-05	2	166	2	9341124
Pubmed	Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.	FLNA FLNB	2.26e-05	2	166	2	21325628
Pubmed	NF-κB-regulated transcriptional control of CLCA in a differentiated mouse keratinocyte line.	CLCA2 NFKB1	2.26e-05	2	166	2	25828855
Pubmed	Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-κB.	NFKB1 CCAR2	2.26e-05	2	166	2	23588592
Pubmed	Structural and functional aspects of filamins.	FLNA FLNB	2.26e-05	2	166	2	11336782
Pubmed	The variants at FLNA and FLNB contribute to the susceptibility of hypertension and stroke with differentially expressed mRNA.	FLNA FLNB	2.26e-05	2	166	2	33649519
Pubmed	NSD1 mitigates caspase-1 activation by listeriolysin O in macrophages.	CASP1 NSD1	2.26e-05	2	166	2	24058709
Pubmed	Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.	GAD1 IGSF9	2.26e-05	2	166	2	24647940
Pubmed	Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling.	FLNA NFKB1	2.26e-05	2	166	2	26552704
Pubmed	Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo.	TNIP2 NFKB1	2.26e-05	2	166	2	16554025
Pubmed	TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain.	CD163 TREM2	2.26e-05	2	166	2	35306602
Pubmed	TREM2 Is a Prognostic Biomarker and Correlated with an Immunosuppressive Microenvironment in Thyroid Cancer.	NFKB1 TREM2	2.26e-05	2	166	2	36438899
Pubmed	Attenuation of IL-32-induced caspase-1 and nuclear factor-κB activations by acteoside.	CASP1 NFKB1	2.26e-05	2	166	2	26453510
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MYCN FLNA GBF1 WASHC2C EML4 DBN1 ZNF106 MDC1 SVIL SEC16A CCAR2 TNKS1BP1 CCDC9 ZMYM3	2.28e-05	774	166	14	15302935
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	IFT140 PRSS56 GAS7 LBR ANKHD1 TEP1 TYK2 FCSK UBR5 PIK3R1 SUPT16H SEC16A SCO1 ZNF324 OSMR ZMYM3 CDH16	2.69e-05	1116	166	17	31753913
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	MYCN ELAPOR2 GBF1 BCORL1 LBR TNRC18 CDK5RAP3 NFKB1 SVIL NLE1 CDK5RAP2 FGD5 MTCL1	2.92e-05	689	166	13	36543142
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	ELAPOR2 IFT140 KLK6 GBF1 WASHC2C L3MBTL2 DBN1 KIF24 PTHLH ZNF106 DDHD1 ALDH16A1 NFKB1 SCO1 CDK5RAP2 DCAF11 ZRANB1 SLX4	2.97e-05	1242	166	18	30973865
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	FLNA GBF1 ADCK2 LBR HNRNPAB EML3 PIK3R1 SVIL	3.33e-05	255	166	8	15324660
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FLNA FLNB L3MBTL2 BCORL1 ANKHD1 UBR5 SEC16A TNKS1BP1 ZMYM3 S100PBP	3.55e-05	418	166	10	34709266
Pubmed	CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.	GRWD1 WASHC2C LBR ANKHD1 NFKB1 EXOSC6 CREB3L2	5.42e-05	201	166	7	34917906
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	FLNA FLNB DBN1 HNRNPAB SVIL SEC16A CCAR2 PLEKHA7	5.52e-05	274	166	8	34244482
Pubmed	Serum amyloid A activates nuclear factor-kappaB in rheumatoid synovial fibroblasts through binding to receptor of advanced glycation end-products.	SAA1 NFKB1	6.77e-05	3	166	2	18322992
Pubmed	Nuclear receptor binding SET domain protein 1 promotes epithelial-mesenchymal transition in paclitaxel-resistant breast cancer cells via regulating nuclear factor kappa B and F-box and leucine-rich repeat protein 11.	NSD1 NFKB1	6.77e-05	3	166	2	34905470
Pubmed	Regulation of TREM2 expression by an NF-кB-sensitive miRNA-34a.	NFKB1 TREM2	6.77e-05	3	166	2	23462268
Pubmed	Association of GTF2I, NFKB1, and TYK2 Regional Polymorphisms With Systemic Sclerosis in a Chinese Han Population.	TYK2 NFKB1	6.77e-05	3	166	2	34248934
Pubmed	Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading.	FLNA FLNB	6.77e-05	3	166	2	28175289
Pubmed	Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.	SAA1 NFKB1	6.77e-05	3	166	2	16236134
Pubmed	Human atlastin GTPases mediate differentiated fusion of endoplasmic reticulum membranes.	ATL3 ATL1	6.77e-05	3	166	2	25773277
Pubmed	Neurocan is dispensable for brain development.	TNC NCAN	6.77e-05	3	166	2	11486035
Pubmed	NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma.	PIK3R1 NFKB1	6.77e-05	3	166	2	20433747
Pubmed	Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.	FLNA FLNB	6.77e-05	3	166	2	12393796
Pubmed	Inhibition of the PI3K/AKT-NF-κB pathway with curcumin enhanced radiation-induced apoptosis in human Burkitt's lymphoma.	PIK3R1 NFKB1	6.77e-05	3	166	2	23603894
Pubmed	Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma.	TNC NCAN	6.77e-05	3	166	2	21997179
Pubmed	Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family.	LMTK3 AATK	6.77e-05	3	166	2	17651901
Pubmed	Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants.	PIK3R1 NFKB1	6.77e-05	3	166	2	34922003
Pubmed	Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.	FLNA FLNB	6.77e-05	3	166	2	11153914
Pubmed	PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control and Pharmacogenetics Study.	EPM2A NMBR	6.77e-05	3	166	2	27092952
Pubmed	Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line.	NFKB1 TREM2	6.77e-05	3	166	2	23778113
Pubmed	Filamins as integrators of cell mechanics and signalling.	FLNA FLNB	6.77e-05	3	166	2	11252955
Pubmed	Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory breast cancer cells.	TNC NFKB1	6.77e-05	3	166	2	27717868
Pubmed	Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase.	TYK2 PIK3R1	6.77e-05	3	166	2	10542297
Pubmed	GATA-6 and NF-κB activate CPI-17 gene transcription and regulate Ca2+ sensitization of smooth muscle contraction.	GATA6 NFKB1	6.77e-05	3	166	2	23275439
Pubmed	The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis.	NFKB1 PLEKHA7	6.77e-05	3	166	2	36823376
Pubmed	Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.	GDF5 NFKB1	6.77e-05	3	166	2	25223801
Pubmed	Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis.	BCORL1 ARMCX4	6.77e-05	3	166	2	32376790
Pubmed	GPIbα regulates platelet size by controlling the subcellular localization of filamin.	FLNA FLNB	6.77e-05	3	166	2	22174152
Pubmed	Age-Dependent Alterations in the Interactions of NF-κB and N-myc with GLT-1/EAAT2 Promoter in the Pericontusional Cortex of Mice Subjected to Traumatic Brain Injury.	MYCN NFKB1	6.77e-05	3	166	2	26081154
Pubmed	Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.	MAMDC4 SEC16A	6.77e-05	3	166	2	25956157
Pubmed	PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.	GDF5 PIK3R1	6.77e-05	3	166	2	24944017
Pubmed	Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-κB pathway in mast cells.	CASP1 NFKB1	6.77e-05	3	166	2	21463955
Pubmed	Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.	ATL3 ATL1	6.77e-05	3	166	2	27669642
Pubmed	Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation.	FLNA FLNB	6.77e-05	3	166	2	38989458
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	GDF5 TNC HAPLN2 HKDC1 PTHLH NCAN DMBT1	7.13e-05	210	166	7	16537572
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	FLNA HNRNPAB ARHGEF15 CCDC43 MMP24 UBR5 MDC1 SEC16A FGD5 DMBT1 ZRANB1 VSIG10L2 NOTCH4	7.30e-05	754	166	13	35906200
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	FLNA FLNB GBF1 ATL3 LBR DBN1 CCDC43 CDK5RAP3 UBR5 SEC16A TNKS1BP1	9.68e-05	568	166	11	37774976
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	GBF1 ARHGEF15 AATK NRXN1 UBR5 SEC16A TNKS1BP1	1.10e-04	225	166	7	12168954
Pubmed	Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.	CASP1 ZNF746	1.35e-04	4	166	2	35654037
Pubmed	Granulocyte macrophage colony-stimulating factor shows anti-apoptotic activity via the PI3K-NF-κB-HIF-1α-survivin pathway in mouse neural progenitor cells.	PIK3R1 NFKB1	1.35e-04	4	166	2	24022164
Pubmed	Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components.	TNC NCAN	1.35e-04	4	166	2	29367009
Pubmed	The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.	HAPLN2 NCAN	1.35e-04	4	166	2	11027579
Pubmed	ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.	TNIP2 NFKB1	1.35e-04	4	166	2	15169888
Pubmed	The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.	FLNA FLNB	1.35e-04	4	166	2	11739414
Pubmed	Interaction of presenilins with the filamin family of actin-binding proteins.	FLNA FLNB	1.35e-04	4	166	2	9437013
Pubmed	Structural interaction and functional regulation of polycystin-2 by filamin.	FLNA FLNB	1.35e-04	4	166	2	22802962
Pubmed	Role of TNF receptor-associated factor 3 in the CD40 signaling by production of reactive oxygen species through association with p40phox, a cytosolic subunit of nicotinamide adenine dinucleotide phosphate oxidase.	NCF4 PIK3R1	1.35e-04	4	166	2	14688330
Pubmed	Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species.	PIK3R1 NFKB1	1.35e-04	4	166	2	19693771
Pubmed	The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation.	FLNA TNIP2	1.35e-04	4	166	2	12753905
Pubmed	A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex.	FLNA PIK3R1	1.35e-04	4	166	2	18299448
Pubmed	Extracellular matrix alterations in brains lacking four of its components.	TNC NCAN	1.35e-04	4	166	2	15694392
Pubmed	Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.	TNC NCAN	1.35e-04	4	166	2	23637166
Pubmed	Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.	TNC NCAN	1.35e-04	4	166	2	28512860
Pubmed	Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.	TNC NCAN	1.35e-04	4	166	2	31558805
Pubmed	Regulation of phosphatidylinositol 3-kinase (PI3K)/Akt and nuclear factor-kappa B signaling pathways in dystrophin-deficient skeletal muscle in response to mechanical stretch.	PIK3R1 NFKB1	1.35e-04	4	166	2	16741926
Pubmed	Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.	TNC NCAN	1.35e-04	4	166	2	35721494
Pubmed	Transcriptional regulation of the endogenous danger signal tenascin-C: a novel autocrine loop in inflammation.	TNC NFKB1	1.35e-04	4	166	2	20107185
Pubmed	Changes in the expression of membrane type-matrix metalloproteinases genes (MMP14, MMP15, MMP16, MMP24) during treatment and their potential impact on the survival of patients with non-small cell lung cancer (NSCLC).	MMP24 MMP15	1.35e-04	4	166	2	35062057
Pubmed	Neural extracellular matrix regulates visual sensory motor integration.	TNC NCAN	1.35e-04	4	166	2	38318351
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNA FLNB GRWD1 NSD1 DBN1 MDC1 SUPT16H	1.40e-04	234	166	7	36243803
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	BCORL1 NSD1 TARS2 ANKHD1 ZNF106 SBNO1 MTCL1	1.72e-04	242	166	7	34011540
Pubmed	Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.	CDK5RAP3 MDC1 CCAR2 TNKS1BP1	1.86e-04	59	166	4	28813667
Pubmed	NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.	TRHDE FLNA FLNB KLK6 DBN1 HNRNPAB NFKB1 ZMYM3	2.11e-04	333	166	8	32665550
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	GBF1 WASHC2C L3MBTL2 CABLES1 NDC80 CDK5RAP2 PLEKHA7	2.15e-04	251	166	7	29778605
Pubmed	NF-kappaB, and not MYCN, regulates MHC class I and endoplasmic reticulum aminopeptidases in human neuroblastoma cells.	MYCN NFKB1	2.24e-04	5	166	2	20103633
Pubmed	Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.	FLNA FLNB	2.24e-04	5	166	2	12006559
Interaction	TOP3B interactions	MYCN FLNA GBF1 GRWD1 NOB1 HECTD4 APBB3 NSD1 DGKQ ANKHD1 TEP1 EML3 CABLES1 TYK2 CNPPD1 TNRC18 AATK NDC80 FAM83F PROM2 MDC1 SVIL EXOSC6 SUPT16H SEC16A NLE1 TNK2 TNKS1BP1 ATG9A ZNF324B	1.93e-06	1470	162	30	int:TOP3B
Interaction	MEX3A interactions	MYCN FLNA FLNB L3MBTL2 NSD1 TNRC18 NFKB1 SVIL EXOSC6 SUPT16H SEC16A TNKS1BP1 MTCL1	1.43e-05	384	162	13	int:MEX3A
Interaction	NTPCR interactions	MYCN IFT140 TNIP2 AATK ZNF746 ATG9A ZRANB1 EPHA5	1.44e-05	136	162	8	int:NTPCR
GeneFamily	WD repeat domain containing	IFT140 GRWD1 EML4 TEP1 EML3 NLE1 DCAF11	5.58e-04	262	98	7	362
GeneFamily	Gelsolin/villins	GSN SVIL	7.97e-04	8	98	2	950
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHSL2 LMTK3 ARHGEF25 ARHGEF15 ATL1 SLC41A2 CRYGN FGD5 OSMR	2.41e-08	177	167	9	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GATA6 ARMCX4 PTHLH TTLL7 CLEC14A FGD5 OSMR NOTCH4	4.06e-08	188	167	9	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA TNC IRAG1 ARHGEF25 TTLL7 PDLIM4 SVIL MTCL1 SPOCD1	4.25e-08	189	167	9	f7e2ee5047792ab9ef6472fa88e2d193cdea6fa0
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 GATA6 PTHLH ARHGEF15 TTLL7 FGD5 OSMR NOTCH4	5.09e-07	185	167	8	f98af3146ec2f44c30d31a662fb9c4fa3ca4f706
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKK1 CACNA1A PTHLH ARHGEF15 TTLL7 FGD5 OSMR NOTCH4	5.52e-07	187	167	8	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	wk_08-11-Epithelial-PNS-intermediate_Schwann\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KLK6 GAS7 GSN PDLIM4 AATK NRXN1 MMP15 EPHA5	5.75e-07	188	167	8	3f3a744b2615bf72f6119f26087099110c0d21fc
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA CHODL TNC IRAG1 ARHGEF25 TTLL7 SVIL SPOCD1	5.99e-07	189	167	8	ab7ece0a517499b70b7754720d3e434765363af6
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA TNC IRAG1 ARHGEF25 PDLIM4 SVIL MTCL1 OSMR	5.99e-07	189	167	8	63449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTHLH ARHGEF15 TTLL7 CLEC14A XRRA1 FGD5 MMP15 NOTCH4	6.23e-07	190	167	8	cb8798839c27f307955fcc94a1ee40bca95b8e99
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTHLH ARHGEF15 TTLL7 CLEC14A XRRA1 FGD5 MMP15 NOTCH4	6.23e-07	190	167	8	5bf3d0beee69879c95265d07fba023626a7cc808
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	FLNA TNC IRAG1 ARHGEF25 PDLIM4 PIK3R1 SVIL MTCL1	9.17e-07	200	167	8	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	LPS_anti-TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FLNA TNC IRAG1 ARHGEF25 PDLIM4 PIK3R1 SVIL MTCL1	9.17e-07	200	167	8	c596a53c0b63c9deaac7d99fcbdd94ecfa96b86c
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	FLNA TNC IRAG1 ARHGEF25 PDLIM4 PIK3R1 SVIL MTCL1	9.17e-07	200	167	8	dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCell	E16.5-samps-Myeloid-Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CASP1 CD163 PDLIM4 TG AATK TREM2 PSD4	1.47e-06	148	167	7	cd5f697d8c2f272be1f3f52a05446749278431c5
ToppCell	E16.5-samps-Myeloid-Macrophage-CD163+_Macrophage\|E16.5-samps / Age Group, Lineage, Cell class and subclass	CASP1 CD163 PDLIM4 TG AATK TREM2 PSD4	1.47e-06	148	167	7	56e146980a71b5ca655118ae13310c5949220d4a
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1A FLNA TNC IRAG1 ARHGEF25 TTLL7 SLC22A31	2.48e-06	160	167	7	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	CACNA1A FLNA TNC IRAG1 ARHGEF25 TTLL7 SLC22A31	2.58e-06	161	167	7	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	Thalamus-Hematopoietic\|Thalamus / BrainAtlas - Mouse McCarroll V32	RUBCNL CASP1 NCF4 ARHGAP30 CD163 TREM2 PSD4	3.16e-06	166	167	7	76d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCell	PCW_13-14-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KLK6 PDLIM4 AATK NRXN1 FAM83F NCAN EPHA5	4.31e-06	174	167	7	0d8e737860120dcd3a6b57992c612595904d585e
ToppCell	PCW_13-14-Neuronal-Neuronal_SCP\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KLK6 TTLL7 PDLIM4 AATK NRXN1 NCAN EPHA5	4.83e-06	177	167	7	621dd82f1393c961d4dd7a615aa52c9df9e36336
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_NA\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KLK6 PRSS56 TTLL7 AATK NRXN1 MMP15 EPHA5	4.83e-06	177	167	7	8c78f7de091f16e86e326a73c9f1429e0232821f
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA ACP5 CD163 SVIL ALPK3 SPOCD1 GLTPD2	5.01e-06	178	167	7	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GATA6 ARMCX4 PTHLH ABCB4 FGD5 OSMR	5.59e-06	181	167	7	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB GATA6 ARMCX4 ARHGEF15 CLEC14A FGD5 NOTCH4	6.01e-06	183	167	7	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA CHODL TNC IRAG1 ARHGEF25 PDLIM4 SVIL	6.01e-06	183	167	7	61a73de857f4ae02dcba3af348f436f602b28ff2
ToppCell	Control-Myeloid-Macrophage_Alveolar\|World / Disease state, Lineage and Cell class	TRHDE ACP5 CABLES1 SVIL ALPK3 FGD5 SPOCD1	6.45e-06	185	167	7	85cb81759589a26d83676cffbf2bc37399683c10
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB GATA6 ARMCX4 PTHLH CLEC14A OSMR NOTCH4	6.68e-06	186	167	7	9c7924875f70420720149287c500b4dfa8d24673
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GATA6 ARMCX4 PTHLH PDLIM4 TNKS1BP1 SLC16A11 OSMR	6.68e-06	186	167	7	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRHDE MYCN KLK6 RUBCNL PRSS56 TTLL7 NRXN1	6.68e-06	186	167	7	3113c85d0ac5fc46532c19b1bb71f34b985e1276
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB GATA6 ARMCX4 PTHLH CLEC14A OSMR NOTCH4	6.92e-06	187	167	7	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB GATA6 ARMCX4 PTHLH CLEC14A OSMR NOTCH4	6.92e-06	187	167	7	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA CHODL TNC IRAG1 TTLL7 SVIL SPOCD1	7.17e-06	188	167	7	879de94924de978478696fc7838e05a4d795b905
ToppCell	droplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTHLH ARHGEF15 TTLL7 CLEC14A FGD5 MMP15 NOTCH4	7.42e-06	189	167	7	2ce330d8078833c05775c481e73770f9ee4a5c88
ToppCell	droplet-Kidney-nan-21m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTHLH ARHGEF15 TTLL7 CLEC14A FGD5 MMP15 NOTCH4	7.42e-06	189	167	7	473c87036e04a058b4a5138438b7ba7e1e766799
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NHSL2 ARMCX4 PTHLH TTLL7 CLEC14A FGD5 NOTCH4	7.68e-06	190	167	7	eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCell	PND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NHSL2 ARMCX4 PTHLH TTLL7 CLEC14A FGD5 NOTCH4	7.68e-06	190	167	7	3346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	FLNB RUBCNL GSN SLC41A2 MTCL1 MMP15 NOTCH4	7.95e-06	191	167	7	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	10x5'v1-week_12-13-Endothelial-stroma-tip_EC\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ARHGEF15 MMP24 CLEC14A SLC16A11 FGD5 MMP15 NOTCH4	7.95e-06	191	167	7	cf1a67b7c0d5c0dc5d4d59faf9d9b1a3a1fb00e0
ToppCell	Control-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	TRHDE EML4 ACP5 SVIL ALPK3 FGD5 SPOCD1	7.95e-06	191	167	7	a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 GATA6 PTHLH ARHGEF15 CLEC14A FGD5 NOTCH4	7.95e-06	191	167	7	b9ae5af426e7a1f2652a47700bb168371bd2dec6
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 PTHLH ARHGEF15 TTLL7 CLEC14A FGD5 NOTCH4	8.22e-06	192	167	7	c0498baa2556e1597c00df2e75efadeb14bd34ef
ToppCell	droplet-Kidney-KIDNEY-1m-Endothelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 PTHLH ARHGEF15 TTLL7 CLEC14A FGD5 NOTCH4	8.22e-06	192	167	7	cb906b10cad76e978c5c0b966215368ebef30e51
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA TNC IRAG1 PTHLH SVIL MTCL1 EPHA5	8.50e-06	193	167	7	5578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ELAPOR2 KLK6 HAPLN2 TMEM235 GSN TTLL7 AATK	8.80e-06	194	167	7	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
ToppCell	normal_Lung-Epithelial_cells-Undetermined\|Epithelial_cells / Location, Cell class and cell subclass	TRHDE ACP5 NCF4 CD163 TREM2 FGD5 SPOCD1	9.09e-06	195	167	7	31710a593d503e46acad1db38adacace4d863388
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA IRAG1 ARHGEF25 GSN TTLL7 SVIL SPOCD1	9.09e-06	195	167	7	eb2003d4f15cad213d17eda8ab7479f5a0c62164
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA IRAG1 ARHGEF25 GSN TTLL7 SVIL SPOCD1	9.09e-06	195	167	7	44f67437ea65d530133a0240b17f9860d9cc0e99
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-myocytic\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLNA IRAG1 GSN TTLL7 SVIL MTCL1 SPOCD1	9.40e-06	196	167	7	20dc9b25ecc23b6e6e52bbab8b5a404f3245ca37
ToppCell	10x5'v1-week_12-13-Endothelial-stroma\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GATA6 ARHGEF15 CLEC14A ALPK3 FGD5 MMP15 NOTCH4	1.00e-05	198	167	7	122215d9288533ad03562cf777e846504863df9a
ToppCell	10x5'v1-week_12-13-Endothelial\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	GATA6 ARHGEF15 CLEC14A ALPK3 FGD5 MMP15 NOTCH4	1.00e-05	198	167	7	307dd09e6bc820a148f3000f18dae7aedba4be0b
ToppCell	distal-2-Hematologic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FLNA EML4 ACP5 NCF4 ARHGAP30 CD163 TREM2	1.04e-05	199	167	7	6eb7dc2e170da139f3fb80bed2076d5f7a06b4b2
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA TNC PDLIM4 LMAN1L TNKS1BP1 OSMR SPOCD1	1.04e-05	199	167	7	85bb28369e0568b7b3bda095722102fc793f60ef
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KLK6 CDHR2 HAPLN2 ANKRD33 FAM83F	1.06e-05	77	167	5	4720aa099bd00d05b721634eedc9a08b0213ee67
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	KLK6 CDHR2 HAPLN2 ANKRD33 FAM83F	1.06e-05	77	167	5	25a8dd4cdba4d96d6b0c35fa6310bfff6ce64265
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CACNA1A TNC ADCK2 IRAG1 ARHGEF25 TTLL7 XPNPEP3	1.07e-05	200	167	7	a372ef3f9e6ff6e3c3376d6e10182977c5067788
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	TRHDE IRAG1 ATL1 PDLIM4 FGD5 SPOCD1	2.64e-05	155	167	6	e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ELAPOR2 ZAN CDHR2 SIM1 DMBT1 EPHA5	3.39e-05	162	167	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	368C-Myeloid-Dendritic-cDC1\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FLNB RUBCNL DBN1 EML3 CLEC14A SLX4	3.51e-05	163	167	6	299ac2463b7f58eee419d822a2a2d64b973d87e9
ToppCell	E18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	FLNB NHSL2 RUBCNL ARMCX4 CLEC14A FGD5	3.51e-05	163	167	6	d6f9b7280c44d120df5a72dfc2ebb26ffbb5752b
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KLK6 RUBCNL GAS7 PDLIM4 NRXN1 MMP15	3.63e-05	164	167	6	57301178e420983c0cb72178e288a3a0449fdda3
ToppCell	Mild/Remission-B_memory-6\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA FLNB TNIP2 ACP5 NCF4 GSN	3.88e-05	166	167	6	03e1a369d8a83b814def07e29cabb023226b4828
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ACP5 CNPPD1 CLEC14A TREM2 ZNF324B SLX4	3.88e-05	166	167	6	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GAS7 MAMDC4 CD163 PDLIM4 TREM2 IGSF9	4.15e-05	168	167	6	aaafa7243c44e6852d92e3445335fc4a1018f416
ToppCell	droplet-Lung-21m-Hematologic-myeloid-interstitial_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GAS7 MAMDC4 CD163 PDLIM4 TREM2 IGSF9	4.15e-05	168	167	6	06787d4f08ddf052127404a0ea6a85e1b048e206
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPM2A GRWD1 B3GALT6 GAS7 NDC80 SUPT16H	4.43e-05	170	167	6	45de83a2231208b8e1f21061d0b91644b4a3ba93
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GAS7 ARHGAP30 ZNF831 CD163 HROB NDC80	4.58e-05	171	167	6	55c7bf7211587fa08df13c0a4ff5b78a85d5439e
ToppCell	10x3'2.3-week_17-19-Myeloid_DC-DC-tDC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZAN CASP1 SLC41A2 KCNC3 TREM2 HHIPL1	4.58e-05	171	167	6	b327fb7813a3cdae06c8a4f8a0c256e9a20132f6
ToppCell	wk_20-22-Epithelial-PNS\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KLK6 GAS7 PDLIM4 AATK NRXN1 EPHA5	4.89e-05	173	167	6	17b1a6b0318925d5d920f2c0a791745b9587ebef
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ARHGEF15 CLEC14A NCAN FGD5 NOTCH4	4.89e-05	173	167	6	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA EML4 ACP5 CD163 DDHD1 SPOCD1	5.05e-05	174	167	6	d5c22b43531414951666ee7542a66ed9380e2d14
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RUBCNL GAS7 PDLIM4 AATK NRXN1 EPHA5	5.05e-05	174	167	6	667035a11b68745fa8446d6c68214713be42710f
ToppCell	wk_20-22-Epithelial-PNS-Late_Schwann\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	KLK6 GAS7 PDLIM4 AATK NRXN1 EPHA5	5.38e-05	176	167	6	81924471d8a8c5bd8eedf294c007e25b6cd3e417
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Macrophage\|GI_small-bowel / Manually curated celltypes from each tissue	ACP5 CD163 GSN SAA1 SVIL TREM2	5.38e-05	176	167	6	4be270f6bb7da4070f972aca403109751646d155
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMCX4 ARHGEF15 CLEC14A TNK2 FGD5 OSMR	5.38e-05	176	167	6	c4d9166e5bbb7ca544107db14e4374289f5de6bd
ToppCell	droplet-Kidney-KIDNEY-30m-Endothelial-kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMCX4 ARHGEF15 CLEC14A TNK2 FGD5 OSMR	5.38e-05	176	167	6	d58ef51002ea50b3037636038214bbb7454cb503
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ANKHD1 ZNF831 FCSK HROB TNRC18 SVIL	5.55e-05	177	167	6	36b5d29caa9cffbc0284f771a4db71aa72171a89
ToppCell	Mild/Remission-B_memory-6\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA FLNB TNIP2 ACP5 NCF4 GSN	5.55e-05	177	167	6	8f2ce5ffc94ca90412cb6899629f322dc778215c
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GATA6 PTHLH PDLIM4 ABCB4 CLCA2 OSMR	5.55e-05	177	167	6	d68132e145bd413404fdbe215b5dbe520e756e50
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-monocytoid_macrophage\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ACP5 CD163 GSN ANKRD33 TREM2 PLEKHA7	5.73e-05	178	167	6	e44b0aa82890ae84fc4d1343f1c65ae2fda69a11
ToppCell	wk_08-11-Epithelial-PNS-Proliferating_Schwann\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KLK6 GAS7 PDLIM4 AATK NRXN1 EPHA5	5.91e-05	179	167	6	ab23fee9adab1e63d5b5cd9faba6b9a92beef425
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GAD1 ATL1 TTLL7 CLEC14A SPINDOC NOTCH4	5.91e-05	179	167	6	025d414ec88d5680d99c8173e70ee3bb0b694f74
ToppCell	nucseq-Epithelial-Epithelial_Glandular\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK6 CDHR2 CLCA2 PROM2 IGSF9 ENTPD8	5.91e-05	179	167	6	859cd8ee414ad6207c046ada2e655e49322dd01c
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1A GATA6 PTHLH MMP24 AATK OSMR	5.91e-05	179	167	6	b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK6 CDHR2 CLCA2 PROM2 IGSF9 ENTPD8	6.09e-05	180	167	6	668a2d8e1d5a390309d5eb62c836f5903144bea9
ToppCell	nucseq-Epithelial-Epithelial_Glandular-Goblet\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	KLK6 CDHR2 CLCA2 PROM2 IGSF9 ENTPD8	6.09e-05	180	167	6	3dc80bc636bf0e6ffc9762853132a9fe59fd1f66
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_SCP_(0)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRHDE MYCN KLK6 RUBCNL PRSS56 NRXN1	6.28e-05	181	167	6	fad7ba168f541ac9d04edebc206f191e48bb7e99
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHSL2 LMTK3 ARHGEF25 ATL1 CRYGN OSMR	6.28e-05	181	167	6	4df7972f88117108698efd06b124b232f8588981
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GATA6 ARMCX4 ARHGEF15 CLEC14A FGD5 NOTCH4	6.28e-05	181	167	6	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophage_CCL3+-Alveolar_macrophage_CCL3+_L.1.0.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ACP5 RUBCNL TEP1 CD163 NLE1 SPOCD1	6.28e-05	181	167	6	a8d4b2340d99734bf9379b467fb481c598b9b4fb
ToppCell	Control-Myeloid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RUBCNL CASP1 GAS7 NCF4 ARHGAP30 CD163	6.28e-05	181	167	6	25170e5285996cc80337d5f86a0255569861ae77
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NHSL2 LMTK3 ARHGEF25 ATL1 CRYGN OSMR	6.28e-05	181	167	6	cbb530566893281289026bfd93adf721decd4ca3
ToppCell	droplet-Lung-nan-3m-Epithelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR2 CABLES1 KCNC3 SLC16A11 SPINDOC CDH16	6.48e-05	182	167	6	cfba75c1ffc39ac76db9e8e27394731942882b30
ToppCell	3'_v3-bone_marrow-Myeloid_Mac\|bone_marrow / Manually curated celltypes from each tissue	TRHDE ACP5 CD163 GSN TREM2 SPOCD1	6.48e-05	182	167	6	e1d6b5de5bd1d11e968da3a55e5326ef252f55ba
ToppCell	droplet-Lung-nan-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR2 CABLES1 KCNC3 SLC16A11 SPINDOC CDH16	6.48e-05	182	167	6	d836bfdc298ecd3558a973e393a329eb8bd59d79
ToppCell	droplet-Lung-nan-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELAPOR2 CABLES1 KCNC3 SLC16A11 SPINDOC CDH16	6.48e-05	182	167	6	7e7c7a26460d3003cdf0c0ffb96208a566aa09a7
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	CACNA1A FLNA FLNB TNC IRAG1 TTLL7	6.68e-05	183	167	6	818fd886e0188091310825f9145fa53328f2c979
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Mac-Macrophage\|lymph-node_spleen / Manually curated celltypes from each tissue	ACP5 CD163 SAA1 TREM2 FGD5 SPOCD1	6.68e-05	183	167	6	0bcbd60e10b9d6898915dab1987fd46dc7238b19
ToppCell	wk_15-18-Epithelial-PNS-intermediate_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MYCN KLK6 TNC ADCK2 PDLIM4 NRXN1	6.68e-05	183	167	6	d874aa9a856f79626c8a8371f6196a77b7d662ee
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TRHDE MYCN RUBCNL PRSS56 TTLL7 NRXN1	6.68e-05	183	167	6	e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1A FLNA FLNB TNC IRAG1 TTLL7	6.68e-05	183	167	6	cae2ee08f985a6f005b4b8e959e465350315156a
Computational	Genes in the cancer module 202.	FLNA FLNB GSN SVIL	1.04e-04	28	96	4	MODULE_202
Computational	Actin cytoskeleton binding.	FLNA FLNB GSN SVIL	1.37e-04	30	96	4	MODULE_524
Computational	Genes in the cancer module 419.	FLNA FLNB GSN SVIL	2.26e-04	34	96	4	MODULE_419
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	TRHDE MYCN CDHR2 CASP1 GAS7 ADCK2 TEP1 TNK2 CCDC9 PSD4	1.64e-06	197	163	10	3189_UP
Disease	Disproportionate short stature	GDF5 FLNA FLNB IFT140 ACP5 B3GALT6	4.29e-06	77	162	6	C0878659
Disease	hereditary spastic paraplegia 3A (implicated_via_orthology)	ATL3 ATL1	8.95e-05	3	162	2	DOID:0110791 (implicated_via_orthology)
Disease	myofibrillar myopathy 5 (implicated_via_orthology)	FLNA FLNB	8.95e-05	3	162	2	DOID:0080096 (implicated_via_orthology)
Disease	distal muscular dystrophy 4 (implicated_via_orthology)	FLNA FLNB	8.95e-05	3	162	2	DOID:0111190 (implicated_via_orthology)
Disease	non-high density lipoprotein cholesterol measurement	CACNA1A NSD1 DGKQ SIM1 ARHGEF15 CD163 ABCB4 TYK2 LMAN1L SBNO1 NCAN SPINDOC GLTPD2	1.65e-04	713	162	13	EFO_0005689
Disease	Osteoarthritis, Knee	GDF5 SBNO1	1.78e-04	4	162	2	C0409959
Disease	mean arterial pressure, alcohol drinking	HECTD4 MAPKAPK5-AS1 ZNF831 LMAN1L PLEKHA7	2.11e-04	98	162	5	EFO_0004329, EFO_0006340
Disease	Malignant neoplasm of breast	FLNA FLNB BCORL1 DBN1 SIM1 MAMDC4 PTHLH GSN CLCA2 FAM83F SBNO1 NLE1 FGD5 NMBR SPOCD1 NOTCH4	2.95e-04	1074	162	16	C0006142
Disease	kallikrein-7 measurement	KLK6 CD163	2.96e-04	5	162	2	EFO_0008195
Disease	serum alanine aminotransferase measurement	GBF1 BCORL1 HECTD4 HKDC1 CDCP2 TARS2 ABCB4 FCSK MMP24 PIK3R1 NCAN SLC38A7 MMP15 NOTCH4	3.29e-04	869	162	14	EFO_0004735
Disease	hematocrit	ZAN PELI3 BCORL1 HECTD4 HKDC1 SIM1 IRAG1 ARHGEF15 GSN ANKRD33 FGD5 DMBT1 OSMR NOTCH4 PSD4	4.78e-04	1011	162	15	EFO_0004348
Disease	Angle Closure Glaucoma	PRSS56 PLEKHA7	6.18e-04	7	162	2	C0017605
Disease	Large cell carcinoma of lung	ANKK1 ALPK3 EPHA5	7.17e-04	32	162	3	C0345958
Disease	systolic blood pressure, alcohol drinking	HECTD4 MAPKAPK5-AS1 ZNF831 LMAN1L PLEKHA7	7.21e-04	128	162	5	EFO_0004329, EFO_0006335
Disease	Hereditary Sensory Autonomic Neuropathy, Type 1	ATL3 ATL1	8.21e-04	8	162	2	C0020071
Disease	microcephaly (is_implicated_in)	NSD1 CDK5RAP2	8.21e-04	8	162	2	DOID:10907 (is_implicated_in)
Disease	lymphocyte count	MYCN FLNB GBF1 ZAN HECTD4 NSD1 HKDC1 ZNF831 ARHGEF15 PDLIM4 TYK2 LMAN1L SBNO1 PIK3R1 NFKB1 BTN2A3P DMBT1 PSD4	1.18e-03	1464	162	18	EFO_0004587
Disease	body weights and measures	GDF5 CABLES1 PIK3R1	1.19e-03	38	162	3	EFO_0004324
Disease	systemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus	FLNB DGKQ TYK2	1.19e-03	38	162	3	EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Disease	primary biliary cholangitis (is_implicated_in)	LBR ABCB4	1.31e-03	10	162	2	DOID:12236 (is_implicated_in)
Disease	Secondary Biliary Cholangitis	ABCB4 TYK2 NFKB1	1.59e-03	42	162	3	C0238065
Disease	Biliary cirrhosis	ABCB4 TYK2 NFKB1	1.59e-03	42	162	3	C0023892
Disease	Biliary Cirrhosis, Primary, 1	ABCB4 TYK2 NFKB1	1.59e-03	42	162	3	C4551595
Disease	total hip arthroplasty, osteoarthritis	TNC PTHLH PIK3R1	1.59e-03	42	162	3	EFO_0009806, MONDO_0005178
Disease	chronic kidney disease, Proteinuria	CACNA1A GAS7	1.59e-03	11	162	2	EFO_0003884, HP_0000093
Disease	Primary biliary cirrhosis	ABCB4 TYK2 NFKB1	2.21e-03	47	162	3	C0008312
Disease	Spastic Paraplegia, Hereditary	ATL1 DDHD1	2.61e-03	14	162	2	C0037773
Disease	body weights and measures, body height	GDF5 CABLES1	3.00e-03	15	162	2	EFO_0004324, EFO_0004339
Disease	tonsillectomy risk measurement	HECTD4 MAPKAPK5-AS1 PIK3R1 NFKB1 MDC1 NOTCH4	3.22e-03	260	162	6	EFO_0007924
Disease	neutrophil count	CACNA1A FLNB WASHC2C BCORL1 HECTD4 NSD1 TMEM235 TARS2 CABLES1 CD1A CDK5RAP3 AATK SBNO1 BTN2A3P CCDC9 NOTCH4	4.00e-03	1382	162	16	EFO_0004833
Disease	diastolic blood pressure, alcohol drinking	HECTD4 MAPKAPK5-AS1 ZNF831 PLEKHA7	4.14e-03	118	162	4	EFO_0004329, EFO_0006336
Disease	Insulin Resistance	CASP1 CD163 PIK3R1	4.42e-03	60	162	3	C0021655
Disease	Insulin Sensitivity	CASP1 CD163 PIK3R1	4.42e-03	60	162	3	C0920563
Disease	osteochondrodysplasia (is_implicated_in)	FLNA FLNB	4.82e-03	19	162	2	DOID:2256 (is_implicated_in)
Disease	Bipolar Disorder	ANKK1 CACNA1A GAD1 HTR5A DBN1 NRXN1 NCAN NOTCH4	5.00e-03	477	162	8	C0005586
Disease	Osteoarthritis of hip	GDF5 TNC	5.33e-03	20	162	2	C0029410
Disease	seborrheic dermatitis	ELAPOR2 TNRC18	5.33e-03	20	162	2	EFO_1000764

Protein segments in the cluster

Peptide	Gene	Start	Entry
GSRGLSDPWADSVGV	TRHDE	11	Q9UKU6
FTGASGVTVPEEGWT	BTN2A3P	471	Q96KV6
EAVLVGGEWSPSLDG	CCAR2	356	Q8N163
GRHIATDFETGLGPW	MAMDC4	266	Q6UXC1
TDFETGLGPWNRSEG	MAMDC4	271	Q6UXC1
REGSLEQPGFWEGEA	CACNA1A	906	O00555
APGDVWARFAVGTAG	B3GALT6	86	Q96L58
GDDWGSILSFENREP	ADCK2	191	Q7Z695
LGQDTFWVTEPEAGG	ARHGEF25	356	Q86VW2
SLGAGQGREDPSWEG	LINC00588	56	Q9Y4M8
VEGVVDAAWSDRGPG	ALDH16A1	291	Q8IZ83
AFDGASEEAPLLGNW	CDCP2	321	Q5VXM1
GSLPVFTRDDFEGDW	ANKK1	11	Q8NFD2
PLGSGAYRSVGEWLE	EPHA5	961	P54756
VGGSDGERTAPFCSW	B3GALT4	346	O96024
GRAEGDPGVSWDFYS	BCORL1	1621	Q5H9F3
TREPEGGTLAAWQEG	ALPK3	441	Q96L96
LRWGAGYSGEDPFSV	DGKQ	686	P52824
LSEELWGVGEDGSPS	ARHGEF15	361	O94989
GESAGRSPGELAWDA	CLIC6	316	Q96NY7
GGGGEWSTTLLSPRE	DLGAP4	336	Q9Y2H0
GESWAGSRPGNEAIG	ARMCX4	1681	Q5H9R4
SFGVVRRGEWDAPSG	TNK2	136	Q07912
EASGEGWKGQDPFRD	CDK5RAP2	1576	Q96SN8
VEAFGDPSERAWVAG	NSD1	366	Q96L73
AGLGPGDFDWEELLA	PAAT	36	Q9H8K7
WEGISDHSGIIDGSP	RUBCNL	16	Q9H714
ASWGGIVHLEAFGDP	ANKRD33	11	Q7Z3H0
IAGTEGGFSLSWKPQ	OSMR	536	Q99650
GGPDLWADRTEVGRA	MTCL1	1446	Q9Y4B5
FADGEVVRGRWPGSS	LBR	6	Q14739
GFGSWLDGRLEALGV	CCDC43	21	Q96MW1
GIGGDTHFDSDEPWT	MMP24	251	Q9Y5R2
AAQDGAEPGRVDTFW	EPM2A	71	O95278
ESWGGPLLAAAVAYG	SLC16A11	336	Q8NCK7
NESGSVPEGWERDFL	NMBR	16	P28336
SDDDGGGWITPSNIK	NOB1	201	Q9ULX3
RSVPGLDGSGWEVFD	GDF5	281	P43026
DLDSDPFGEDGSLWS	MAF1	171	Q9H063
PAEGDAGAEWAAAVL	MDC1	601	Q14676
EGDVGLSPYLAGWRA	GLTPD2	96	A6NH11
WSRREPFLLSGGDDG	GRWD1	316	Q9BQ67
DGGWLADGSVRFPIT	HAPLN2	291	Q9GZV7
TSPWEGDERGFLGIA	HHIPL1	241	Q96JK4
ICVDGGPSTDGLDWF	L3MBTL2	461	Q969R5
LGSGEGGLTESWAEA	EXOSC6	226	Q5RKV6
GRSPVDFWGAELLAG	ENTPD8	151	Q5MY95
WDGIGIFFDSPAEDT	LMAN1L	131	Q9HAT1
PGWTGSLLGDREEAA	MMP15	11	P51511
ASGSFLLSGWDPEGR	LMTK3	601	Q96Q04
LLSGWDPEGRGAGET	LMTK3	606	Q96Q04
GGLGDPGDFSDIQWT	ARNTL2	621	Q8WYA1
GTQRGDILPSADGTW	CD1A	246	P06126
VSPEGGLAISKDFWG	C9orf131	356	Q5VYM1
IVGWSSKDGDGIFSP	GAD1	236	Q99259
WSIFGADAAEVPGTR	IRAG1	21	Q9Y6F6
FEWQLPGSDIASGSD	FAM199X	136	Q6PEV8
PAEFSIWTREAGAGG	FLNB	2211	O75369
DVGWSVLDVAFTPDG	DCAF11	216	Q8TEB1
CSLEDSGPWAGEGVF	FGD5	176	Q6ZNL6
SGPWAGEGVFQSDLL	FGD5	181	Q6ZNL6
DWLEGTVRGATGIFP	NCF4	206	Q15080
AEETGLDGSWGFPGK	KIF24	1176	Q5T7B8
SQASVEEDFGRGPWL	HROB	441	Q8N3J3
VVADGAGLPGEDWVF	GFUS	26	Q13630
AATSLIDLWPGNGEG	DBN1	471	Q16643
ELGSGLEFPGAEGQW	NRXN1	26	Q9ULB1
GFSDGQEARPEEIGW	PIK3R1	41	P27986
DVTLSPGDVAGIGWE	HECTD4	2061	Q9Y4D8
GDGAAWSPRSFGAED	CRYGN	136	Q8WXF5
GSGIKFDEWDELPAG	ELAPOR2	131	A8MWY0
AWRPTSAEGDFELGI	ABCB4	11	P21439
TFGGGFELHTWSELP	FCSK	821	Q8N0W3
GPGGNLSSWEDLLLF	GATA6	101	Q92908
AEDPGTGTEGIWGLR	APBB3	66	O95704
DEWGAAGGVAVPTLN	CNPPD1	146	Q9BV87
SYSTRPGWFDIGADG	CDHR2	281	Q9BYE9
AAGSSGFEAVEVAWP	HYI	26	Q5T013
PLTGFSWRGGSERET	ATL1	106	Q8WXF7
RGDSPGVVWFKDSVG	CASP1	286	P29466
FASPLGAGRASGEQW	CABLES1	166	Q8TDN4
PAEFSIWTREAGAGG	FLNA	2256	P21333
LAGALSPGEAWPFES	CCDC9	516	Q9Y3X0
FSRLPLGGWAEDGQS	ATG9A	801	Q7Z3C6
SAEAAGIDWGIFPES	CDK5RAP3	286	Q96JB5
PLLFGWGETYSEGSE	HTR5A	176	P47898
LGDPEEPLTGFSWRG	ATL3	96	Q6DD88
FSWRGGSDPETTGIQ	ATL3	106	Q6DD88
GRLLASSPAGEAGSW	MAPKAPK5-AS1	96	Q8N8E1
SADARGGGPSALWEI	GBF1	1686	Q92538
SEPDGFWEALGGKAA	GSN	636	P06396
GVWPDGSDGTDINSL	EML3	786	Q32P44
GVWPEGSDGTDINAL	EML4	781	Q9HC35
GGAWELGSDARPAFG	DDHD1	21	Q8NEL9
SAHFGEGTGPIWLDE	CD163	771	Q86VB7
WFGQGSGPIALDDVR	DMBT1	156	Q9UGM3
LWRFAEASGVGPGDS	SLC22A31	286	A6NKX4
GAPFSWDSLDEDGLD	S100PBP	21	Q96BU1
GLEFWGPAEGTARVL	SCO1	26	O75880
LGIWGEGTPFREFSD	SBNO1	491	A3KN83
DFLGSPGAEGKDRWA	IFT140	356	Q96RY7
ERGDTEGTFGLDWEP	CDH16	491	O75309
EGTFGLDWEPDSGHV	CDH16	496	O75309
SAGELGGWDRGSSLL	CREB3L2	446	Q70SY1
AIAGWGALFEDGPEA	PRSS56	226	P0CW18
WFGGSLDGFLLTPIT	OR2T11	146	Q8NH01
LDGTPGERAWGSRAS	ARHGAP30	971	Q7Z6I6
EGTAGGWGVFPEVSR	IER5	156	Q5VY09
EFGEPWDLNSGDGAF	TARS2	521	Q9BW92
AVDWSPDGQRVASGG	NLE1	461	Q9NVX2
LGSTEEAGGRSLWFP	TMEM41A	31	Q96HV5
EAGGRSLWFPSDLAE	TMEM41A	36	Q96HV5
EAVPEASRGRGWTGA	HNRNPAB	21	Q99729
CDEGSEPLGFWDALG	SVIL	1966	O95425
WGAFGDDGALEDIRT	HKDC1	261	Q2TB90
WEAGRGAEAFPATLS	AATK	481	Q6ZMQ8
PLSLAEGGAEDADWG	AATK	616	Q6ZMQ8
TAEEGGGFAWDDDFP	AATK	1291	Q6ZMQ8
GWKEPGEAFVGGRTS	NHSL2	1126	Q5HYW2
GFSEDSAPGVWREIS	PELI3	246	Q8N2H9
EGEKEDGLRGWFPAS	GAS7	41	O60861
GSPGVESFWEEVASG	NCAN	976	O14594
SPWGFRLVGGRDFSA	PDLIM4	11	P50479
SEPEGEGQAWLREGT	PSD4	216	Q8NDX1
LPRGWEEGFTEEGAS	PLEKHA7	56	Q6IQ23
FPEGLGEAWGHSSRT	SIM1	56	P81133
KSEWEASPGGLDRGT	SLC38A7	36	Q9NVC3
GPSSGGGFVDWTLRL	SLC41A2	16	Q96JW4
VSWEQEFLVGSSPGG	SPINDOC	71	Q9BUA3
GWSFLEPEGEGSDAE	SUPT16H	921	Q9Y5B9
VAAGRGGRVSTDDWP	NOTCH4	1936	Q99466
RGWVFTPGVDDAESE	PMVK	141	Q15126
GASGGESAWRLESFL	FAM83F	361	Q8NEG4
GPGGVWAAEAISDAR	SAA1	66	P0DJI8
DADWLEGGSPVSGQL	SLX4	876	Q8IY92
QGWGDGPLSSRVATD	ANKHD1	2226	Q8IWZ3
RGFSWLSSDPGGLES	CLEC14A	111	Q86T13
NLTKPGTGISDGDFW	CHODL	86	Q9H9P2
LTLSWTAPGEDFDQG	CLCA2	781	Q9UQC9
GSGGWEEAPRAAAAL	TNIP2	6	Q8NFZ5
GFEAGPEASDDDLWT	TNRC18	1981	O15417
PVGLVEEAGSRSAGW	PHETA2	181	Q6ICB4
GGQEPSTWDELGEAL	ZNF324	236	O75467
VADAGNGSAWPGRAE	TMEM235	36	A6NFC5
SDGSVGLWDPESGQR	TEP1	2126	Q99973
ELWGSPAEEDAFGLG	MYCN	86	P04198
DRPAVSSWALGGDSG	SEC16A	866	O15027
TLAEGFPGLEAASRW	PROM2	386	Q8N271
GAGDFLWLDQSPRGD	SPOCD1	221	Q6ZMY3
EDGSTLFRGWSQEGP	TNKS1BP1	211	Q9C0C2
ATPDGFRLSWTADEG	TNC	1631	P24821
GATPALRFVAVGDWG	ACP5	21	P13686
TLWITGGDGDRASPG	TMDD1	241	P0DPE3
ARFGRGSGPVWTEAF	SCART1	281	Q4G0T1
TEEALAAAAAPWEGG	WASHC2C	1071	Q9Y4E1
LDKFPGWSQGTEGSL	IGSF9	366	Q9P2J2
AWLDSGVTGSGLEGD	PTHLH	146	P12272
RDAGDLWFPGESESF	TREM2	136	Q9NZC2
FPGVGTDRGDSWALV	FP248	191	Q71RG6
ELWDGPRSGTDGAIA	XPNPEP3	161	Q9NQH7
EEPWGLSQLDSGAGD	ZNF746	216	Q6NUN9
GWPEERASFVGSGLG	ZNF831	971	Q5JPB2
LGPGAGAWETAASDI	VSIG10L2	641	P0DP72
SEGWPAIDGSFLAAV	TG	2311	P01266
SGNGSEEAWGALRAP	WBP1	6	Q96G27
GEPDLSSLEGFQWEG	ZNF106	831	Q9H2Y7
LYDESVDWNGGRGSP	XRRA1	276	Q6P2D8
GTLAWDAGDQTLEPG	ZMYM3	101	Q14202
PFKSGSSDVGRDWDP	ZRANB1	41	Q9UGI0
VFPGLATAGGDWTEG	TEX13B	166	Q9BXU2
TDKRGSLSGIGPDWG	TTLL7	831	Q6ZT98
PWFLSGSETLGRLAG	UBR5	111	O95071
DGAFVLEGWGRSFPS	TYK2	511	P29597
GGQEPSTWDELGEAL	ZNF324B	236	Q6AW86
DGSPAGDKEELGNSW	ZAN	1306	Q9Y493
DVCGPLFEEELGFWG	KCNC3	161	Q14003
LGWGKTADGDFPDTI	KLK6	141	Q92876
SSPLFDDGQPWGEET	NDC80	201	O14777
GGVWEGFGDFSPTDV	NFKB1	291	P19838