Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	neuroligin family protein binding	NRXN1 NRXN2	8.53e-05	5	59	2	GO:0097109
GeneOntologyMolecularFunction	gamma-tubulin binding	PDE4B PAK1 TUBGCP5	1.92e-04	38	59	3	GO:0043015
GeneOntologyBiologicalProcess	observational learning	NRXN1 NRXN2 PAK1	1.84e-06	9	59	3	GO:0098597
GeneOntologyBiologicalProcess	regulation of protein kinase A signaling	PDE4A NRXN1 FSHR	3.78e-05	23	59	3	GO:0010738
GeneOntologyBiologicalProcess	developmental growth	TYMS EIF4H ATRX MYCBP2 DSPP FSHR FSTL4 PAK1 GRHL2 HNRNPK NRP2	4.70e-05	911	59	11	GO:0048589
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	NRXN1 PAK1	4.81e-05	4	59	2	GO:0150036
GeneOntologyBiologicalProcess	neuroligin clustering involved in postsynaptic membrane assembly	NRXN1 NRXN2	4.81e-05	4	59	2	GO:0097118
GeneOntologyBiologicalProcess	gephyrin clustering involved in postsynaptic density assembly	NRXN1 NRXN2	8.00e-05	5	59	2	GO:0097116
GeneOntologyBiologicalProcess	presynaptic active zone assembly	NRXN1 BSN	8.00e-05	5	59	2	GO:1904071
GeneOntologyBiologicalProcess	branchiomotor neuron axon guidance	MYCBP2 NRP2	1.67e-04	7	59	2	GO:0021785
GeneOntologyBiologicalProcess	vocal learning	NRXN1 NRXN2	1.67e-04	7	59	2	GO:0042297
GeneOntologyBiologicalProcess	imitative learning	NRXN1 NRXN2	1.67e-04	7	59	2	GO:0098596
GeneOntologyBiologicalProcess	trans-synaptic signaling by lipid, modulating synaptic transmission	NRXN1 PAK1	2.23e-04	8	59	2	GO:0099552
GeneOntologyBiologicalProcess	trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	NRXN1 PAK1	2.23e-04	8	59	2	GO:0099553
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4A PDE4B	2.86e-04	9	59	2	GO:0006198
GeneOntologyBiologicalProcess	protein localization to synapse	GRIP1 NRXN1 NRXN2 BSN	3.29e-04	115	59	4	GO:0035418
GeneOntologyBiologicalProcess	protein kinase A signaling	PDE4A NRXN1 FSHR	3.51e-04	48	59	3	GO:0010737
GeneOntologyBiologicalProcess	positive regulation of synapse maturation	NRXN1 HNRNPK	3.57e-04	10	59	2	GO:0090129
GeneOntologyBiologicalProcess	presynaptic active zone organization	NRXN1 BSN	3.57e-04	10	59	2	GO:1990709
GeneOntologyBiologicalProcess	cell junction organization	CDH22 NRXN1 NRXN2 MYCBP2 PAK1 BSN GRHL2 ITGB4 HNRNPK NRP2	4.02e-04	974	59	10	GO:0034330
GeneOntologyBiologicalProcess	postsynaptic density protein 95 clustering	NRXN1 NRXN2	4.35e-04	11	59	2	GO:0097119
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NRXN1 NRXN2	4.35e-04	11	59	2	GO:0097104
GeneOntologyBiologicalProcess	learned vocalization behavior or vocal learning	NRXN1 NRXN2	4.35e-04	11	59	2	GO:0098598
GeneOntologyBiologicalProcess	cell morphogenesis	GRIP1 FAT1 LIPA CDH22 NRXN1 MYCBP2 FSTL4 PAK1 GRHL2 HNRNPK NRP2	5.02e-04	1194	59	11	GO:0000902
GeneOntologyBiologicalProcess	positive regulation of intracellular estrogen receptor signaling pathway	FSHR PAK1	5.21e-04	12	59	2	GO:0033148
GeneOntologyBiologicalProcess	trans-synaptic signaling by lipid	NRXN1 PAK1	6.15e-04	13	59	2	GO:0099541
GeneOntologyBiologicalProcess	trans-synaptic signaling by endocannabinoid	NRXN1 PAK1	6.15e-04	13	59	2	GO:0099542
GeneOntologyCellularComponent	presynaptic active zone	GRIP1 NRXN1 NRXN2 CTNND1 BSN	4.86e-05	141	59	5	GO:0048786
GeneOntologyCellularComponent	glutamatergic synapse	GRIP1 CNNM2 NRXN1 NRXN2 PAK1 CTNND1 BSN ITGB4 HNRNPK NRP2	8.70e-05	817	59	10	GO:0098978
GeneOntologyCellularComponent	GABA-ergic synapse	GRIP1 NRXN1 CLPTM1 PAK1 BSN	9.94e-05	164	59	5	GO:0098982
GeneOntologyCellularComponent	somatodendritic compartment	GRIP1 PDE4B EFHC1 NRXN1 TRIM9 PJVK PAK1 CTNND1 MAP1LC3B BSN HNRNPK	5.68e-04	1228	59	11	GO:0036477
GeneOntologyCellularComponent	cell cortex	GRIP1 PJVK CTNND1 BSN ITGB4 HNRNPK	6.12e-04	371	59	6	GO:0005938
GeneOntologyCellularComponent	axon	GRIP1 NRXN1 MYCBP2 PAK1 CTNND1 MAP1LC3B BSN HNRNPK NRP2	8.25e-04	891	59	9	GO:0030424
GeneOntologyCellularComponent	Schaffer collateral - CA1 synapse	PDE4A NRXN1 CTNND1 BSN	9.64e-04	155	59	4	GO:0098685
GeneOntologyCellularComponent	autolysosome	MAP1LC3B GAA	1.16e-03	18	59	2	GO:0044754
GeneOntologyCellularComponent	cell-cell junction	FAT1 CDH22 NRXN1 ASH1L PAK1 CTNND1 GRHL2	1.33e-03	591	59	7	GO:0005911
GeneOntologyCellularComponent	anchoring junction	FAT1 CDH22 NRXN1 ASH1L PAK1 CTNND1 GRHL2 ITGB4 HNRNPK	1.56e-03	976	59	9	GO:0070161
GeneOntologyCellularComponent	gamma-tubulin complex	PDE4B TUBGCP5	1.59e-03	21	59	2	GO:0000930
GeneOntologyCellularComponent	vacuolar lumen	LIPA GLB1 DNAJC3 GAA	1.61e-03	178	59	4	GO:0005775
GeneOntologyCellularComponent	presynaptic active zone cytoplasmic component	CTNND1 BSN	1.91e-03	23	59	2	GO:0098831
GeneOntologyCellularComponent	secondary lysosome	MAP1LC3B GAA	2.44e-03	26	59	2	GO:0005767
GeneOntologyCellularComponent	lysosomal lumen	LIPA GLB1 GAA	2.69e-03	98	59	3	GO:0043202
GeneOntologyCellularComponent	dendrite	GRIP1 PDE4B TRIM9 PAK1 CTNND1 MAP1LC3B BSN HNRNPK	2.71e-03	858	59	8	GO:0030425
GeneOntologyCellularComponent	dendritic tree	GRIP1 PDE4B TRIM9 PAK1 CTNND1 MAP1LC3B BSN HNRNPK	2.75e-03	860	59	8	GO:0097447
GeneOntologyCellularComponent	presynapse	GRIP1 PDE4B NRXN1 NRXN2 TRIM9 CTNND1 BSN HNRNPK	3.30e-03	886	59	8	GO:0098793
GeneOntologyCellularComponent	excitatory synapse	PDE4B NRXN1 BSN	3.44e-03	107	59	3	GO:0060076
GeneOntologyCellularComponent	cytoplasmic region	EFHC1 CTNND1 MAP1LC3B BSN DNAH6	3.44e-03	360	59	5	GO:0099568
GeneOntologyCellularComponent	inhibitory synapse	NRXN1 BSN	3.45e-03	31	59	2	GO:0060077
GeneOntologyCellularComponent	neuron to neuron synapse	GRIP1 PDE4B NRXN1 PAK1 CTNND1 BSN	3.50e-03	523	59	6	GO:0098984
GeneOntologyCellularComponent	catenin complex	CDH22 CTNND1	3.68e-03	32	59	2	GO:0016342
GeneOntologyCellularComponent	extrinsic component of membrane	PDE4A CDH22 CTNND1 BSN	4.05e-03	230	59	4	GO:0019898
GeneOntologyCellularComponent	dendritic spine	GRIP1 PDE4B CTNND1 HNRNPK	4.85e-03	242	59	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	GRIP1 PDE4B CTNND1 HNRNPK	5.21e-03	247	59	4	GO:0044309
GeneOntologyCellularComponent	synaptic membrane	GRIP1 NRXN1 NRXN2 BSN ITGB4 NRP2	5.91e-03	583	59	6	GO:0097060
HumanPheno	Abnormal tongue morphology	GRIP1 GLB1 EIF4H NRXN1 ATRX KDM5C REV3L CPLANE1 GAA HNRNPK	1.45e-05	386	27	10	HP:0030809
Domain	ConA-like_dom	FAT1 NRXN1 NRXN2 TRIM9 ITGB4 BTN2A1 NRP2	3.94e-06	219	56	7	IPR013320
Domain	Syndecan	NRXN1 NRXN2	1.84e-04	7	56	2	PF01034
Domain	Syndecan/Neurexin_dom	NRXN1 NRXN2	1.84e-04	7	56	2	IPR027789
Domain	LAM_G_DOMAIN	FAT1 NRXN1 NRXN2	2.00e-04	38	56	3	PS50025
Domain	Laminin_G_2	FAT1 NRXN1 NRXN2	2.33e-04	40	56	3	PF02210
Domain	LamG	FAT1 NRXN1 NRXN2	3.10e-04	44	56	3	SM00282
Domain	HGTP_anticodon	TARS3 PARS2	3.14e-04	9	56	2	PF03129
Domain	-	ATRX MYCBP2 TRIM9 KDM5C RLIM ASH1L BSN	3.71e-04	449	56	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	ATRX MYCBP2 TRIM9 KDM5C RLIM ASH1L BSN	4.24e-04	459	56	7	IPR013083
Domain	aa-tRNA-synt_IIb	TARS3 PARS2	4.77e-04	11	56	2	IPR002314
Domain	tRNA-synt_2b	TARS3 PARS2	4.77e-04	11	56	2	PF00587
Domain	-	TARS3 PARS2	4.77e-04	11	56	2	3.40.50.800
Domain	Laminin_G	FAT1 NRXN1 NRXN2	7.01e-04	58	56	3	IPR001791
Domain	Anticodon-bd	TARS3 PARS2	7.85e-04	14	56	2	IPR004154
Domain	Neurexin-like	NRXN1 NRXN2	7.85e-04	14	56	2	IPR003585
Domain	4.1m	NRXN1 NRXN2	7.85e-04	14	56	2	SM00294
Domain	Znf_FYVE_PHD	ATRX KDM5C ASH1L BSN	9.85e-04	147	56	4	IPR011011
Domain	aa-tRNA-synth_II	TARS3 PARS2	1.31e-03	18	56	2	IPR006195
Domain	AA_TRNA_LIGASE_II	TARS3 PARS2	1.31e-03	18	56	2	PS50862
Domain	-	GLB1 MYCBP2 NRP2	1.37e-03	73	56	3	2.60.120.260
Domain	PDEase	PDE4A PDE4B	1.46e-03	19	56	2	IPR023088
Domain	PDEase_I	PDE4A PDE4B	1.79e-03	21	56	2	PF00233
Domain	PDEASE_I	PDE4A PDE4B	1.79e-03	21	56	2	PS00126
Domain	PDEase_CS	PDE4A PDE4B	1.79e-03	21	56	2	IPR023174
Domain	-	MYCBP2 UBR5	1.96e-03	22	56	2	2.130.10.30
Domain	-	PDE4A PDE4B	1.96e-03	22	56	2	1.10.1300.10
Domain	PDEase_catalytic_dom	PDE4A PDE4B	2.15e-03	23	56	2	IPR002073
Domain	RCC1/BLIP-II	MYCBP2 UBR5	2.15e-03	23	56	2	IPR009091
Domain	HDc	PDE4A PDE4B	2.34e-03	24	56	2	SM00471
Domain	HD/PDEase_dom	PDE4A PDE4B	2.34e-03	24	56	2	IPR003607
Domain	Galactose-bd-like	GLB1 MYCBP2 NRP2	2.82e-03	94	56	3	IPR008979
Domain	ZF_PHD_2	ATRX KDM5C ASH1L	2.91e-03	95	56	3	PS50016
Domain	-	FAT1 NRXN1 NRXN2	2.91e-03	95	56	3	2.60.120.200
Domain	ZF_PHD_1	ATRX KDM5C ASH1L	3.00e-03	96	56	3	PS01359
Domain	EF_HAND_1	EFHC1 PPP3R2 USP32 FSTL4	3.26e-03	204	56	4	PS00018
Domain	EF_HAND_2	EFHC1 PPP3R2 USP32 FSTL4	5.06e-03	231	56	4	PS50222
Domain	EF_hand_dom	EFHC1 PPP3R2 USP32 FSTL4	5.14e-03	232	56	4	IPR002048
Pubmed	Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.	NRXN1 NRXN2 BSN	3.87e-07	9	59	3	21356198
Pubmed	Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.	GLB1 BSN ME1	1.31e-06	13	59	3	10508511
Pubmed	Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.	PDE4A PDE4B	2.83e-06	2	59	2	21047676
Pubmed	Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α.	NRXN1 ASH1L	2.83e-06	2	59	2	27229316
Pubmed	Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: the self defense forces study.	TYMS MTR	2.83e-06	2	59	2	22407825
Pubmed	Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.	PAK1 CTNND1	2.83e-06	2	59	2	34412070
Pubmed	Mutations in NRXN1 and NRXN2 in a patient with early-onset epileptic encephalopathy and respiratory depression.	NRXN1 NRXN2	2.83e-06	2	59	2	30709877
Pubmed	A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis.	UBR5 GRHL2	2.83e-06	2	59	2	21949371
Pubmed	Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.	NRXN1 NRXN2	2.83e-06	2	59	2	1621094
Pubmed	Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.	PDE4A PDE4B	2.83e-06	2	59	2	11267656
Pubmed	Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.	NRXN1 NRXN2	2.83e-06	2	59	2	26595880
Pubmed	Blood mRNA expression of REV3L and TYMS as potential predictive biomarkers from platinum-based chemotherapy plus pemetrexed in non-small cell lung cancer patients.	TYMS REV3L	2.83e-06	2	59	2	31832811
Pubmed	Thymidylate synthase and methionine synthase polymorphisms are not associated with susceptibility to childhood acute lymphoblastic leukemia in Kurdish population from Western Iran.	TYMS MTR	2.83e-06	2	59	2	21643952
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	ATRX KDM5C RLIM	3.10e-06	17	59	3	19571810
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SEL1L FAT1 GLB1 MYCBP2 CLPTM1 FSTL4 DNAJC3 ITGB4 BTN2A1 HNRNPK NRP2	4.87e-06	1201	59	11	35696571
Pubmed	Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.	ATRX KDM5C RLIM	8.02e-06	23	59	3	22573614
Pubmed	Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.	NRXN1 NRXN2	8.48e-06	3	59	2	34133920
Pubmed	Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.	NRXN1 NRXN2	8.48e-06	3	59	2	38891114
Pubmed	Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis.	TYMS MTR	8.48e-06	3	59	2	18322994
Pubmed	p120-catenin participates in the progress of gastric cancer through regulating the Rac1 and Pak1 signaling pathway.	PAK1 CTNND1	8.48e-06	3	59	2	26324182
Pubmed	Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.	PDE4A PDE4B	8.48e-06	3	59	2	28356347
Pubmed	Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia.	NRXN1 NRXN2	8.48e-06	3	59	2	21424692
Pubmed	Construction of a D2.B6-Fv-2r congenic mouse strain: nonlethality of the homozygous Fv-2' genotype.	GLB1 ME1	8.48e-06	3	59	2	6939921
Pubmed	Genetic determination of the beta-galactosidase developmental program in mouse liver.	GLB1 ME1	8.48e-06	3	59	2	1009575
Pubmed	The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.	NRXN1 NRXN2	8.48e-06	3	59	2	30858964
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4B	8.48e-06	3	59	2	15585880
Pubmed	Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.	NRXN1 NRXN2	8.48e-06	3	59	2	28013231
Pubmed	One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan.	TYMS MTR	8.48e-06	3	59	2	16051637
Pubmed	alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.	NRXN1 NRXN2	8.48e-06	3	59	2	16406382
Pubmed	Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.	NRXN1 NRXN2	8.48e-06	3	59	2	31812984
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4B	8.48e-06	3	59	2	10213096
Pubmed	Influence of polymorphisms in MTHFR 677 C→T, TYMS 3R→2R and MTR 2756 A→G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC.	TYMS MTR	8.48e-06	3	59	2	21605004
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4B	8.48e-06	3	59	2	24555506
Pubmed	Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.	NRXN1 NRXN2	8.48e-06	3	59	2	12036300
Pubmed	β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.	NRXN1 NRXN2	8.48e-06	3	59	2	26213384
Pubmed	Neurexin gene family variants as risk factors for autism spectrum disorder.	NRXN1 NRXN2	8.48e-06	3	59	2	29045040
Pubmed	Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.	NRXN1 NRXN2	8.48e-06	3	59	2	31005376
Pubmed	Effects of the Bgs locus on mouse beta-galactosidase.	GLB1 ME1	8.48e-06	3	59	2	828052
Pubmed	Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.	NRXN1 NRXN2	8.48e-06	3	59	2	38571813
Pubmed	Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.	NRXN1 NRXN2	8.48e-06	3	59	2	35173587
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4B	8.48e-06	3	59	2	18508768
Pubmed	Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.	NRXN1 BSN	8.48e-06	3	59	2	34320240
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4B	8.48e-06	3	59	2	17404263
Pubmed	The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma.	TYMS MTR	8.48e-06	3	59	2	16333305
Pubmed	Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.	TYMS MTR	8.48e-06	3	59	2	21956592
Pubmed	Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.	PDE4A PDE4B	8.48e-06	3	59	2	11114167
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4B	8.48e-06	3	59	2	16034090
Pubmed	Neurexins are differentially expressed in the embryonic nervous system of mice.	NRXN1 NRXN2	8.48e-06	3	59	2	7722633
Pubmed	Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.	NRXN1 NRXN2	8.48e-06	3	59	2	26446217
Pubmed	Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.	NRXN1 NRXN2	8.48e-06	3	59	2	11944992
Pubmed	Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.	NRXN1 NRXN2	8.48e-06	3	59	2	33058888
Pubmed	Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.	NRXN1 NRXN2	8.48e-06	3	59	2	17035546
Pubmed	Neurexins: three genes and 1001 products.	NRXN1 NRXN2	8.48e-06	3	59	2	9448462
Pubmed	Deletion of α-neurexin II results in autism-related behaviors in mice.	NRXN1 NRXN2	8.48e-06	3	59	2	25423136
Pubmed	Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.	ATRX KDM5C	8.48e-06	3	59	2	27869828
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TARS3 ATRX MYCBP2 TRIM9 USP32 ASH1L PAK1 REV3L EIF2AK1 TUBGCP5 HNRNPK	9.21e-06	1285	59	11	35914814
Pubmed	Cul3-KLHL20 E3 ubiquitin ligase plays a key role in the arms race between HIV-1 Nef and host SERINC5 restriction.	MYCBP2 UBR5 RLIM	1.47e-05	28	59	3	35474067
Pubmed	Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring.	TYMS MTR	1.69e-05	4	59	2	18983896
Pubmed	Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins.	NRXN1 NRXN2	1.69e-05	4	59	2	14983056
Pubmed	One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.	TYMS MTR	1.69e-05	4	59	2	17596206
Pubmed	Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism.	NRXN1 NRXN2	1.69e-05	4	59	2	32706374
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4B	1.69e-05	4	59	2	9371714
Pubmed	One-carbon metabolism-related gene polymorphisms and risk of breast cancer.	TYMS MTR	1.69e-05	4	59	2	18174236
Pubmed	Gene-gene interactions in the folate metabolic pathway influence the risk for acute lymphoblastic leukemia in children.	TYMS MTR	1.69e-05	4	59	2	17454638
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4B	1.69e-05	4	59	2	24732776
Pubmed	Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.	PDE4A PDE4B	1.69e-05	4	59	2	23008439
Pubmed	Predictors for remission in rheumatoid arthritis patients: A systematic review.	TYMS MTR	1.69e-05	4	59	2	20235210
Pubmed	GluRδ2 assembles four neurexins into trans-synaptic triad to trigger synapse formation.	NRXN1 BSN	1.69e-05	4	59	2	22457515
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4B	1.69e-05	4	59	2	34943270
Pubmed	Genetic variation in the folate metabolic pathway and risk of childhood leukemia.	TYMS MTR	1.69e-05	4	59	2	20101025
Pubmed	Folate-metabolizing genes in lymphoma patients from Sweden.	TYMS MTR	1.69e-05	4	59	2	19751277
Pubmed	Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells.	GRHL2 HNRNPK	1.69e-05	4	59	2	19015635
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4B	1.69e-05	4	59	2	21670503
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4B	1.69e-05	4	59	2	32738081
Pubmed	Mapping of aminoacylase-1 and beta-galactosidase-A to homologous regions of human chromosome 3 and mouse chromosome 9 suggests location of additional genes.	GLB1 ME1	1.69e-05	4	59	2	6803586
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4B	1.69e-05	4	59	2	8413254
Pubmed	Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.	TYMS MTR	1.69e-05	4	59	2	17655928
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4B	1.69e-05	4	59	2	15644445
Pubmed	Gene polymorphisms involved in folate and methionine metabolism and increased risk of sporadic colorectal adenocarcinoma.	TYMS MTR	1.69e-05	4	59	2	21603981
Pubmed	CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.	NRXN1 NRXN2	1.69e-05	4	59	2	8786425
Pubmed	Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation.	NRXN1 NRXN2	1.69e-05	4	59	2	17347997
Pubmed	Neurexins cluster Ca2+ channels within the presynaptic active zone.	NRXN1 NRXN2	1.69e-05	4	59	2	32134527
Pubmed	Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children.	TYMS MTR	1.69e-05	4	59	2	18406541
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4B	1.69e-05	4	59	2	11839681
Pubmed	A polymorphism of the methionine synthase reductase gene increases chromosomal damage in peripheral lymphocytes in smokers.	TYMS MTR	1.69e-05	4	59	2	16580699
Pubmed	MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children.	TYMS MTR	1.69e-05	4	59	2	20310006
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4B	1.69e-05	4	59	2	22946044
Pubmed	Polymorphisms in one-carbon metabolism pathway genes and risk for bladder cancer in a Tunisian population.	TYMS MTR	1.69e-05	4	59	2	19837268
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4B	1.69e-05	4	59	2	33609559
Pubmed	Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins.	NRXN1 NRXN2	1.69e-05	4	59	2	35385735
Pubmed	Neurexins regulate presynaptic GABAB-receptors at central synapses.	NRXN1 NRXN2	1.69e-05	4	59	2	33888718
Pubmed	Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.	TYMS MTR	1.69e-05	4	59	2	16284371
Pubmed	Polymorphisms involved in the folate metabolizing pathway and risk of multiple myeloma.	TYMS MTR	1.69e-05	4	59	2	17546637
Pubmed	Isolation and characterization of proteins associated with histone H3 tails in vivo.	ASH1L SSRP1 HNRNPK	1.82e-05	30	59	3	17403666
Pubmed	Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.	NRXN1 NRXN2	2.82e-05	5	59	2	28472659
Pubmed	Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions.	NRXN1 NRXN2	2.82e-05	5	59	2	36709330
Pubmed	Effect of common polymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort.	TYMS MTR	2.82e-05	5	59	2	19427504
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4B	2.82e-05	5	59	2	33944911
Pubmed	Risk of non-Hodgkin lymphoma associated with polymorphisms in folate-metabolizing genes.	TYMS MTR	2.82e-05	5	59	2	16365025
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4A PDE4B	2.82e-05	5	59	2	21652625
GeneFamily	EF-hand domain containing	EFHC1 PPP3R2 USP32 FSTL4	7.30e-04	219	34	4	863
GeneFamily	Phosphodiesterases	PDE4A PDE4B	9.23e-04	24	34	2	681
GeneFamily	Actins\|Deafness associated genes	DSPP PJVK GRHL2	1.24e-03	113	34	3	1152
GeneFamily	X-linked mental retardation\|Angiotensin receptors	ATRX KDM5C	4.45e-03	53	34	2	103
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_500	ATRX TRIM9 RLIM ASH1L CPLANE1	1.01e-05	107	57	5	gudmap_developingGonad_e14.5_ epididymis_500_k2
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#1_top-relative-expression-ranked_200	SEL1L MYCBP2 REV3L	7.82e-05	31	57	3	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_200_k1
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#3_top-relative-expression-ranked_1000	ATRX TRIM9 KDM5C RLIM ASH1L CPLANE1	9.32e-05	275	57	6	gudmap_developingGonad_e14.5_ epididymis_1000_k3
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500	SEL1L CNNM2 ATRX MYCBP2 REV3L GRHL2 DNAJC3	9.68e-05	402	57	7	gudmap_developingKidney_e15.5_anlage of loop of Henle_500
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_500	SEL1L MYCBP2 REV3L DNAJC3	1.89e-04	106	57	4	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k4
CoexpressionAtlas	DevelopingKidney_e15.5_Pelvic Mesenchyme_emap-8241_k-means-cluster#5_top-relative-expression-ranked_1000	SEL1L MYCBP2 REV3L CPLANE1 DNAJC3	2.03e-04	201	57	5	gudmap_developingKidney_e15.5_Pelvic Mesenchyme_1000_k5
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_k-means-cluster#3_top-relative-expression-ranked_500	SEL1L ATRX MYCBP2 REV3L DNAJC3	2.03e-04	201	57	5	gudmap_developingKidney_e15.5_500_k3
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_k-means-cluster#2_top-relative-expression-ranked_1000	ZNF326 ATRX TRIM9 RLIM ASH1L CPLANE1	2.23e-04	323	57	6	gudmap_developingGonad_e11.5_ovary + mesonephros_k2_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k-means-cluster#2_top-relative-expression-ranked_1000	ATRX MYCBP2 ASH1L REV3L CPLANE1 NRP2	2.51e-04	330	57	6	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_k2_1000
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#3_top-relative-expression-ranked_500	SEL1L MYCBP2 REV3L CPLANE1	2.76e-04	117	57	4	gudmap_developingKidney_e15.5_Medullary collecting duct_500_k3
CoexpressionAtlas	DevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000	SEL1L ATRX RLIM REV3L CPLANE1 DNAJC3	2.90e-04	339	57	6	gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#5_top-relative-expression-ranked_1000	CWF19L2 ZNF326 TRIM9 RLIM CPLANE1	4.01e-04	233	57	5	gudmap_developingGonad_e12.5_ovary_k5_1000
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN1 ATRX MYCBP2 ASH1L REV3L	6.01e-06	195	59	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN1 ATRX MYCBP2 ASH1L REV3L	6.01e-06	195	59	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	LPS-antiTNF-Epithelial_alveolar-Mes-Like-AT2_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TYMS FSTL4 GLYATL1B KCNG3	4.81e-05	151	59	4	c06a54afe918b14f885d6a85fbcf81e80f33afae
ToppCell	356C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	NRXN2 CLPTM1 GALNT13 NRP2	7.61e-05	170	59	4	513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 TM6SF2 ITGB4 NRP2	7.79e-05	171	59	4	686f95892c3909973c66c9a27159a070a068f175
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 TM6SF2 ITGB4 NRP2	7.79e-05	171	59	4	f7ba03e7bdb687f93782c936c7b3374cc5b3b77c
ToppCell	PND14-Endothelial-Endothelial_lymphatic\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 TM6SF2 ITGB4 NRP2	7.79e-05	171	59	4	d0ac50071a3854d02113c455fcc940a6ec59bbb9
ToppCell	PND14-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NRXN2 TM6SF2 ITGB4 NRP2	7.79e-05	171	59	4	fbf8e9db00573adcada4b25730e191417b7c9999
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LIPA PDE4B FSTL4 DNAH6	8.15e-05	173	59	4	ee972d9cc68755926512fd3bbe1267098c67cd94
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEL1L PDE4A GRHL2 ITGB4	8.52e-05	175	59	4	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CWF19L2 PAK1 MTR PARS2	8.52e-05	175	59	4	bb058e714d21a0ec8532eaf3c7dd2faf78016bc0
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-plasma_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEL1L GLB1 DNAJC3 GAA	9.10e-05	178	59	4	b902059c3f861108fc64cbdc05e6f44378f5be2c
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 ME1 GRHL2 GALNT13	9.29e-05	179	59	4	04ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell	Epithelial-basal_cell\|World / Lineage, Cell type, age group and donor	GRIP1 PAK1 GRHL2 ITGB4	9.29e-05	179	59	4	d9be6647ec7b22747dc00dce4ea307b6af412dfa
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FAT1 TRIM9 REV3L ME1	9.91e-05	182	59	4	ed6ae0fd8653f213fe29906a6a4e0729a62e1b75
ToppCell	facs-Lung-EPCAM-3m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 NRXN1 GRHL2 ITGB4	1.01e-04	183	59	4	ecac1cfaff7553a60305b34d6cede6973ffb5430
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 ME1 GRHL2 GALNT13	1.01e-04	183	59	4	ff6dde877659cde9daa3263db0932c9c9ef1adac
ToppCell	facs-Lung-EPCAM-3m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 NRXN1 GRHL2 ITGB4	1.01e-04	183	59	4	f6ebfd7f61e912f92bd07313cc213a171747ac03
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TYMS KDM5C MTR EIF2AK1	1.01e-04	183	59	4	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1-AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 ME1 GRHL2 GALNT13	1.06e-04	185	59	4	3bef59cc0aa939d2a7e52f0f6c61bc00528fe50b
ToppCell	droplet-Kidney-nan-18m-Epithelial-Epcam____podocyte-3\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFHC1 FSTL4 DNAH6 ITGB4	1.08e-04	186	59	4	29c79b5a29907d4f3f87ad2ca04840c0f15b7d4e
ToppCell	LPS_only-Epithelial_alveolar-AT_1\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GRIP1 ME1 GRHL2 GALNT13	1.10e-04	187	59	4	ff26a533d310126521efe1d05cf8b9d32e524550
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	CDH22 MYCBP2 BSN GAA	1.12e-04	188	59	4	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CDH22 FSTL4 PAK1 DNAH6	1.12e-04	188	59	4	50c1b1d690f0e9443082f2adf4f1b8e9ce4cd337
ToppCell	facs-Lung-EPCAM-18m-Epithelial-Basal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 NRXN1 GRHL2 ITGB4	1.15e-04	189	59	4	783c1db856f2defe6f3b8748dd0bc29a8102f6d1
ToppCell	facs-Lung-EPCAM-18m-Epithelial-respiratory_basal_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT1 NRXN1 GRHL2 ITGB4	1.15e-04	189	59	4	88b72fafbe58463543e0818f27f3dd9e5b4d34d2
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT1 NRXN1 GRHL2 ITGB4	1.17e-04	190	59	4	47e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCell	facs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FAT1 NRXN1 GRHL2 ITGB4	1.17e-04	190	59	4	261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIP1 FAT1 PPP3R2 NRP2	1.17e-04	190	59	4	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 FSTL4 MTR GRHL2	1.17e-04	190	59	4	b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCell	droplet-Thymus-nan-18m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA ATRX DNAJC3 HNRNPK	1.24e-04	193	59	4	81871f4f2b63ca5f64a9ff12f6c909a34bf52216
ToppCell	droplet-Thymus-nan-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA ATRX DNAJC3 HNRNPK	1.24e-04	193	59	4	12380713db6582749183a19de65d4af9d6469a3f
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CWF19L2 NRXN1 NRXN2 REV3L	1.27e-04	194	59	4	7a66bd7d4fc9c6db861cedd2487f241e406869d1
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	NRXN1 NRXN2 REV3L NRP2	1.27e-04	194	59	4	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	NRXN1 NRXN2 REV3L NRP2	1.27e-04	194	59	4	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NRXN1 TRIM9 FSTL4 PAK1	1.29e-04	195	59	4	2e1df01bf6e4e98e6cd9fb50926e34c5077b8666
ToppCell	metastatic_Lymph_Node-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	PDE4B MYCBP2 PAK1 SSRP1	1.29e-04	195	59	4	7fb5c0911ff09580515d1a1827d7249d6242630c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 FAT1 MTR GRHL2	1.32e-04	196	59	4	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	Bronchial-10x5prime-Epithelial-Epi_alveolar-Dividing_AT2\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TYMS GRIP1 BSN GALNT13	1.34e-04	197	59	4	49689a03ab31e53386dbe15c77c09ca3a14ebf4e
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	NRXN1 NRXN2 MYCBP2 NRP2	1.34e-04	197	59	4	4961f66606f08e399508fd6cabca588e7ab406a8
ToppCell	facs-Tongue-nan-3m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRX RLIM ITGB4 HNRNPK	1.37e-04	198	59	4	22559b161e67b49fe8028bfaf861e069063599f5
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage-macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LIPA ME1 GAA NRP2	1.40e-04	199	59	4	c0dcdda30485bb920d3706dcfb06f11b76b6ea37
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_macrophage\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	LIPA ME1 GAA NRP2	1.40e-04	199	59	4	b827dd8a249f904a0ff930a6c4d3b00fb7bc6fb1
ToppCell	(02)_MMP9/10+-(2)_GFP_FOXI1\|(02)_MMP9/10+ / shred by cell type by condition	ATRX RLIM REV3L DNAJC3	1.40e-04	199	59	4	18a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	ATRX RLIM REV3L DNAJC3	1.40e-04	199	59	4	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ATRX UBR5 ASH1L CTNND1	1.42e-04	200	59	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GRIP1 PDE4B ITGB4 GALNT13	1.42e-04	200	59	4	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Neuronal-Excitatory-eB(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	LIPA PDE4B FSTL4 DNAH6	1.42e-04	200	59	4	51265e30f1138fd79733001d0db759f3dab0aaeb
Drug	AC1O3R20	PDE4A PDE4B KDM5C MTR	7.41e-07	28	58	4	CID006335051
Drug	procymidone	GRIP1 NRXN1 NRXN2 BSN ME1 NRP2	2.73e-06	155	58	6	ctd:C035988
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4B	1.91e-05	3	58	2	DB08299
Drug	Enprofylline	PDE4A PDE4B	1.91e-05	3	58	2	DB00824
Drug	lactobionic acid	GLB1 DSPP GAA	2.02e-05	21	58	3	CID000007314
Drug	methylguanosine	GLB1 MTR GAA	2.68e-05	23	58	3	CID000096373
Drug	indolizidine	GLB1 GRHL2 GAA	3.47e-05	25	58	3	CID000026136
Drug	Piclamilast	PDE4A PDE4B	3.81e-05	4	58	2	DB01791
Drug	AC1L3EHA	LIPA MTR	3.81e-05	4	58	2	CID000139200
Drug	Chlorine	TYMS CDH22 NRXN1 NRXN2 PAK1 SSRP1 NRP2	3.96e-05	367	58	7	ctd:D002713
Drug	Androgen Antagonists	GRIP1 NRXN1 NRXN2 BSN	4.03e-05	75	58	4	ctd:D000726
Drug	Ibudilast	PDE4A PDE4B	6.35e-05	5	58	2	DB05266
Drug	D-22888	PDE4A PDE4B	6.35e-05	5	58	2	CID000197714
Drug	1,7-naphthyridine	PDE4A PDE4B	6.35e-05	5	58	2	CID000009209
Disease	autism spectrum disorder (implicated_via_orthology)	NRXN1 NRXN2 KDM5C ASH1L CTNND1 NRP2	5.49e-07	152	58	6	DOID:0060041 (implicated_via_orthology)
Disease	Autistic Disorder	PDE4A PDE4B NRXN1 NRXN2 KDM5C NRP2	1.25e-05	261	58	6	C0004352
Disease	Neuroendocrine Tumors	TYMS ATRX	2.06e-04	11	58	2	C0206754
Disease	Intellectual Disability	NRXN1 NRXN2 KDM5C RLIM ASH1L HNRNPK	2.43e-04	447	58	6	C3714756
Disease	Lymphoma, Large-Cell, Follicular	TYMS MTR	3.92e-04	15	58	2	C0079745
Disease	Lymphoma, Small Cleaved-Cell, Follicular	TYMS MTR	3.92e-04	15	58	2	C0079765
Disease	Lymphoma, Mixed-Cell, Follicular	TYMS MTR	3.92e-04	15	58	2	C0079758
Disease	Lymphoma, Follicular, Grade 2	TYMS MTR	3.92e-04	15	58	2	C1956132
Disease	Lymphoma, Follicular, Grade 3	TYMS MTR	3.92e-04	15	58	2	C1956131
Disease	Lymphoma, Follicular, Grade 1	TYMS MTR	3.92e-04	15	58	2	C1956130
Disease	Cleft Palate	TYMS MTR CTNND1	5.51e-04	81	58	3	C0008925
Disease	level of Sterol ester (27:1/20:3) in blood serum	NRXN1 TM6SF2	6.36e-04	19	58	2	OBA_2045199
Disease	age at onset, smoking initiation	GRIP1 MYCBP2	6.36e-04	19	58	2	EFO_0004847, EFO_0005670
Disease	Lymphoma, Follicular	TYMS MTR	7.05e-04	20	58	2	C0024301
Disease	Seizures	CNNM2 GLB1 MTR NRP2	9.00e-04	218	58	4	C0036572
Disease	hearing impairment	DSPP PJVK GRHL2	9.60e-04	98	58	3	C1384666
Disease	reticulocyte measurement	FAT1 CNNM2 USP32 ASH1L CTNND1 EIF2AK1 BSN GAA	1.01e-03	1053	58	8	EFO_0010700
Disease	Adenoid Cystic Carcinoma	FAT1 ATRX ITGB4	1.02e-03	100	58	3	C0010606
Disease	Pancreatic Neoplasm	TYMS ATRX CLPTM1	1.02e-03	100	58	3	C0030297
Disease	Head Neoplasms	TYMS FAT1	1.02e-03	24	58	2	C0018675
Disease	Upper Aerodigestive Tract Neoplasms	TYMS FAT1	1.02e-03	24	58	2	C0887900
Disease	Cancer of Head	TYMS FAT1	1.02e-03	24	58	2	C0751177
Disease	opioid use disorder	PDE4B CLPTM1 CTNND1	1.05e-03	101	58	3	EFO_0010702
Disease	Alzheimer disease, gastroesophageal reflux disease	PDE4B UBR5 TRIM9 GALNT13	1.06e-03	228	58	4	EFO_0003948, MONDO_0004975
Disease	Malignant neoplasm of pancreas	TYMS ATRX CLPTM1	1.08e-03	102	58	3	C0346647
Disease	Neck Neoplasms	TYMS FAT1	1.11e-03	25	58	2	C0027533
Disease	Cancer of Neck	TYMS FAT1	1.11e-03	25	58	2	C0746787
Disease	lung small cell carcinoma (is_implicated_in)	FAT1 ATRX	1.39e-03	28	58	2	DOID:5409 (is_implicated_in)
Disease	Mental Depression	PDE4A PDE4B NRXN1 MTR	1.58e-03	254	58	4	C0011570
Disease	Polydactyly	GRIP1 CPLANE1 HNRNPK	1.60e-03	117	58	3	C0152427
Disease	Head and Neck Neoplasms	TYMS FAT1	1.93e-03	33	58	2	C0018671

Protein segments in the cluster

Peptide	Gene	Start	Entry
MEETRPEGSYFSKYS	AKAP2	671	Q9Y2D5
LTGYYKTVEAFDADM	ASH1L	2501	Q9NR48
DSDTMKYYSEVDSDK	CXorf66	326	Q5JRM2
NSDGYDSYDFDDKSM	DSPP	446	Q9NZW4
FSIYDMDKDGYISNG	PPP3R2	96	Q96LZ3
DGRYTDATSKYESVM	DNAJC3	281	Q13217
TEFGDTDMKYLLYED	CCDC83	341	Q8IWF9
LDDRMSDTYTFYSAD	KCNG3	116	Q8TAE7
SEKDEDGFLYMVYAS	MAP1LC3B	101	Q9GZQ8
NGEFYYSFKDRTDMF	FAT1	181	Q14517
MADFDTYDDRAYSSF	EIF4H	1	Q15056
KEAFVRSQMYSTDYD	ME1	536	P48163
KYYGMSSRDAVEDDR	BSN	3421	Q9UPA5
MFEIDYSRDSFLKDG	GLB1	31	P16278
DVDMSVYYDRDGGDK	GPATCH3	361	Q96I76
FLYRSDSDYDMSPKT	PDE4A	146	P27815
YRSDSDYDLSPKAMS	PDE4B	136	Q07343
GDYYTLDDMFVSKAA	CWF19L2	631	Q2TBE0
DDDFDMSRYSSSGYS	FAM219A	116	Q8IW50
TDMAVAKDGFSARYY	NRP2	251	O60462
EDYTMLGSDDFFYIG	NRXN2	416	Q9P2S2
GGDTMYDFYTSIFDK	TUBGCP5	731	Q96RT8
TQEDYTMLGSDDFFY	NRXN1	401	Q9ULB1
EDYDSFLMYSDDVLR	ITGB4	1341	P16144
SDDTFEYMAGSDMTY	GALNT13	241	Q8IUC8
KYMSFTDKSAEDYNS	PAK1	141	Q13153
FKYYMSDDISRDSDG	ATRX	201	P46100
DSDIDYDKNFRFYMT	DNAH6	3156	Q9C0G6
EKFRSASVGAEEYMY	GRHL2	226	Q6ISB3
YESEKSSSLNDEYGM	CPLANE1	1626	Q9H799
QLEGSEYDAKSDMYS	EIF2AK1	501	Q9BQI3
DYNSDSSLTLREFYM	FSTL4	226	Q6MZW2
DDMDSYTNVYRVFSK	GLYATL1B	66	A0A0U1RQE8
YEAGDVSFYNMRDRS	BTN2A1	456	Q7KYR7
DYMDSRRDFTFNKDG	GAA	406	P10253
YDKEASGYVDRDMFF	EFHC1	586	Q5JVL4
EAYDMSALRSLYDFG	CDH22	681	Q9UJ99
EDNESSYSRGFDMTY	FSHR	316	P23945
TLYKDSDMEDFGFSV	GRIP1	1006	Q9Y3R0
YDDLDYGMMSDYGTA	CTNND1	291	O60716
GFYYDMFIEDRAVSS	TARS3	261	A2RTX5
GREFYMKDMYTFDSS	PARS2	201	Q7L3T8
SERLMTAYNSYKDGD	SEL1L	556	Q9UBV2
DETYDYGGFTMMFDD	HNRNPK	231	P61978
SKAYEDDGDDYSSIM	MTR	1111	Q99707
DGELYMFGKDAIYSD	MYCBP2	656	O75592
KEGMNPSYDEYADSD	SSRP1	431	Q08945
SSTKVYDDMAFRYLS	CLPTM1	466	O96005
EGMKFEASAFSYYGV	CNNM2	701	Q9H8M5
DDLFSDYYDKPLSMT	PJVK	271	Q0ZLH3
FAAERDEYGSYTMSE	REV3L	2441	O60673
TGFGELSYFMYSDSD	RLIM	411	Q9NVW2
HFGAEYRDMESDYSG	TYMS	141	P04818
DKMSLYSEADSGYGS	TRIM9	66	Q9C026
DSYVVGFMEFYTKEG	TM6SF2	86	Q9BZW4
TSSMDEDFESDYKKY	USP32	1586	Q8NFA0
DADAMFSEDISYFGY	UBR5	266	O95071
MEDRGRENYSSYSSF	ZNF326	146	Q5BKZ1
SFGEMADSFKADYFN	KDM5C	396	P41229
AFSYDEMAKYDLPAS	LIPA	141	P38571