Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin binding	HHEX CHD8 CHD2 MSH2 TCF7L2 BEND6 SMC2 BRCA1 WRN	3.32e-05	739	45	9	GO:0003682
GeneOntologyMolecularFunction	MutLalpha complex binding	MSH2 WRN	1.04e-04	7	45	2	GO:0032405
GeneOntologyMolecularFunction	armadillo repeat domain binding	CHD8 TCF7L2	1.77e-04	9	45	2	GO:0070016
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD8 CHD2 MSH2 WRN	1.90e-04	127	45	4	GO:0008094
GeneOntologyMolecularFunction	chemokine activity	CCL5 CCL18 CXCL12	2.06e-04	51	45	3	GO:0008009
GeneOntologyMolecularFunction	oxidized purine DNA binding	MSH2 WRN	2.21e-04	10	45	2	GO:0032357
GeneOntologyMolecularFunction	oxidized DNA binding	MSH2 WRN	2.70e-04	11	45	2	GO:0032356
GeneOntologyMolecularFunction	mismatch repair complex binding	MSH2 WRN	2.70e-04	11	45	2	GO:0032404
GeneOntologyMolecularFunction	CCR1 chemokine receptor binding	CCL5 CCL18	3.23e-04	12	45	2	GO:0031726
GeneOntologyMolecularFunction	CCR5 chemokine receptor binding	CCL5 CCL18	3.81e-04	13	45	2	GO:0031730
GeneOntologyMolecularFunction	ATP-dependent activity	CHD8 CHD2 MSH2 SMC2 MYO1A DNAH8 WRN	4.13e-04	614	45	7	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	CHD8 CHD2 MSH2 SMC2 DNAH8 WRN	4.40e-04	441	45	6	GO:0016887
GeneOntologyMolecularFunction	chemokine receptor binding	CCL5 CCL18 CXCL12	8.07e-04	81	45	3	GO:0042379
GeneOntologyMolecularFunction	four-way junction DNA binding	MSH2 WRN	8.29e-04	19	45	2	GO:0000400
GeneOntologyMolecularFunction	damaged DNA binding	MSH2 BRCA1 WRN	8.97e-04	84	45	3	GO:0003684
GeneOntologyMolecularFunction	phospholipase activator activity	CCL5 CCL18	1.22e-03	23	45	2	GO:0016004
GeneOntologyMolecularFunction	lipase activator activity	CCL5 CCL18	1.68e-03	27	45	2	GO:0060229
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CHD8 CHD2 MSH2 WRN	2.83e-03	262	45	4	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD8 CHD2	3.15e-03	37	45	2	GO:0140658
GeneOntologyMolecularFunction	DNA secondary structure binding	MSH2 WRN	3.85e-03	41	45	2	GO:0000217
GeneOntologyMolecularFunction	helicase activity	CHD8 CHD2 WRN	5.41e-03	158	45	3	GO:0004386
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HBP1 HHEX KLF18 CHD2 TCF7L2 ZNF396 ZNF679 STAT2	6.07e-03	1244	45	8	GO:0000978
GeneOntologyMolecularFunction	chemoattractant activity	CCL5 CCL18	6.60e-03	54	45	2	GO:0042056
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HBP1 HHEX KLF18 CHD2 TCF7L2 ZNF396 ZNF679 STAT2	6.89e-03	1271	45	8	GO:0000987
GeneOntologyMolecularFunction	CCR chemokine receptor binding	CCL5 CCL18	7.08e-03	56	45	2	GO:0048020
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	CHD8 CHD2 MSH2 SMC2 DNAH8 WRN	7.51e-03	775	45	6	GO:0017111
GeneOntologyMolecularFunction	DNA helicase activity	CHD8 WRN	8.62e-03	62	45	2	GO:0003678
HumanPheno	Post-vaccination measles	STAT2 IFNAR1	3.53e-05	3	18	2	HP:0020088
Domain	DEAH_ATP_HELICASE	CHD8 CHD2 WRN	1.04e-04	38	45	3	PS00690
Domain	SCY	CCL5 CCL18 CXCL12	1.40e-04	42	45	3	SM00199
Domain	Chemokine_IL8-like_dom	CCL5 CCL18 CXCL12	1.62e-04	44	45	3	IPR001811
Domain	IL8	CCL5 CCL18 CXCL12	1.62e-04	44	45	3	PF00048
Domain	Chromo_domain	CHD8 CHD2	1.51e-03	24	45	2	IPR023780
Domain	SMALL_CYTOKINES_CC	CCL5 CCL18	1.78e-03	26	45	2	PS00472
Domain	Chemokine_CC_CS	CCL5 CCL18	1.78e-03	26	45	2	IPR000827
Domain	Chromo	CHD8 CHD2	1.78e-03	26	45	2	PF00385
Domain	CHROMO_1	CHD8 CHD2	2.06e-03	28	45	2	PS00598
Domain	CHROMO_2	CHD8 CHD2	2.06e-03	28	45	2	PS50013
Domain	Helicase_C	CHD8 CHD2 WRN	2.18e-03	107	45	3	PF00271
Domain	HELICc	CHD8 CHD2 WRN	2.18e-03	107	45	3	SM00490
Domain	Helicase_C	CHD8 CHD2 WRN	2.24e-03	108	45	3	IPR001650
Domain	HELICASE_CTER	CHD8 CHD2 WRN	2.30e-03	109	45	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD8 CHD2 WRN	2.30e-03	109	45	3	PS51192
Domain	DEXDc	CHD8 CHD2 WRN	2.30e-03	109	45	3	SM00487
Domain	Helicase_ATP-bd	CHD8 CHD2 WRN	2.36e-03	110	45	3	IPR014001
Domain	SNF2_N	CHD8 CHD2	2.69e-03	32	45	2	IPR000330
Domain	Chromodomain-like	CHD8 CHD2	2.69e-03	32	45	2	IPR016197
Domain	SNF2_N	CHD8 CHD2	2.69e-03	32	45	2	PF00176
Domain	Chromo/shadow_dom	CHD8 CHD2	2.86e-03	33	45	2	IPR000953
Domain	CHROMO	CHD8 CHD2	2.86e-03	33	45	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD2	3.21e-03	35	45	2	IPR002464
Domain	P-loop_NTPase	CHD8 CHD2 MSH2 SMC2 MYO1A DNAH8 WRN	3.90e-03	848	45	7	IPR027417
Pathway	WP_SARSCOV2_INNATE_IMMUNITY_EVASION_AND_CELLSPECIFIC_IMMUNE_RESPONSE	CCL5 CXCL12 STAT2 IFNAR1	1.83e-05	66	34	4	M40067
Pathway	WP_COMPREHENSIVE_IL17A_SIGNALING	CCL5 C7 CCL18 CXCL12	1.36e-04	110	34	4	MM16642
Pathway	BIOCARTA_IFNA_PATHWAY	STAT2 IFNAR1	2.01e-04	9	34	2	M22056
Pathway	REACTOME_DISEASES_OF_DNA_REPAIR	MSH2 BRCA1 WRN	2.47e-04	51	34	3	M29854
Pathway	WP_INTERFERON_TYPE_I_SIGNALING	MAPKAP1 STAT2 IFNAR1	2.92e-04	54	34	3	M39435
Pathway	REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES	CCL5 CCL18 CXCL12	3.61e-04	58	34	3	MM14978
Pathway	PID_E2F_PATHWAY	CES3 HBP1 BRCA1	7.10e-04	73	34	3	M40
Pathway	REACTOME_LDL_CLEARANCE	CES3 CLTC	8.43e-04	18	34	2	MM15565
Pathway	KEGG_MEDICUS_REFERENCE_DNA_END_RESECTION_AND_RPA_LOADING	BRCA1 WRN	8.43e-04	18	34	2	M47838
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	RSAD2 STAT2 IFNAR1	8.62e-04	78	34	3	M973
Pathway	PID_BETA_CATENIN_NUC_PATHWAY	HBP1 CHD8 TCF7L2	9.28e-04	80	34	3	M223
Pathway	BIOCARTA_IFNA_PATHWAY	STAT2 IFNAR1	9.41e-04	19	34	2	MM1571
Pathway	REACTOME_LDL_CLEARANCE	CES3 CLTC	9.41e-04	19	34	2	M27846
Pathway	WP_CHEMOKINE_SIGNALING_PATHWAY	CCL5 CCL18 CXCL12 STAT2	9.59e-04	184	34	4	MM15943
Pathway	WP_DNA_IRDAMAGE_AND_CELLULAR_RESPONSE_VIA_ATR	MSH2 BRCA1 WRN	9.62e-04	81	34	3	M39490
Pathway	KEGG_CHEMOKINE_SIGNALING_PATHWAY	CCL5 CCL18 CXCL12 STAT2	1.04e-03	188	34	4	M4844
Pathway	WP_IMMUNE_RESPONSE_TO_TUBERCULOSIS	STAT2 IFNAR1	1.38e-03	23	34	2	M39748
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_IFN_SIGNALING_PATHWAY	STAT2 IFNAR1	1.38e-03	23	34	2	M47452
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	STAT2 IFNAR1	1.38e-03	23	34	2	MM15634
Pathway	KEGG_MEDICUS_REFERENCE_TYPE_I_INTERFERON_TO_JAK_STAT_SIGNALING_PATHWAY	STAT2 IFNAR1	1.51e-03	24	34	2	M47908
Pathway	PID_CXCR4_PATHWAY	MAPKAP1 CXCL12 STAT2	1.77e-03	100	34	3	M124
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	BRCA1 WRN	1.77e-03	26	34	2	MM15297
Pathway	WP_CELL_INTERACTIONS_OF_THE_PANCREATIC_CANCER_MICROENVIRONMENT	CCL5 CXCL12	1.77e-03	26	34	2	M46461
Pathway	REACTOME_REGULATION_OF_IFNA_IFNB_SIGNALING	STAT2 IFNAR1	1.77e-03	26	34	2	M982
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES_THROUGH_SYNTHESIS_DEPENDENT_STRAND_ANNEALING_SDSA	BRCA1 WRN	1.91e-03	27	34	2	M27586
Pathway	WP_DRAVET_SYNDROME	MAPKAP1 CHD2	2.05e-03	28	34	2	M45519
Pathway	WP_SARS_CORONAVIRUS_AND_INNATE_IMMUNITY	STAT2 IFNAR1	2.51e-03	31	34	2	M39897
Pathway	WP_TYPE_I_INTERFERON_INDUCTION_AND_SIGNALING_DURING_SARSCOV2_INFECTION	STAT2 IFNAR1	2.51e-03	31	34	2	M39859
Pathway	KEGG_MEDICUS_REFERENCE_IFN_RIPK1_3_SIGNALING_PATHWAY	STAT2 IFNAR1	2.51e-03	31	34	2	M47964
Pathway	PID_SYNDECAN_4_PATHWAY	CCL5 CXCL12	2.68e-03	32	34	2	M165
Pathway	REACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX	CHD8 TCF7L2	2.68e-03	32	34	2	MM14975
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION	STAT2 IFNAR1	2.84e-03	33	34	2	M39909
Pathway	WP_DNA_REPAIR_PATHWAYS_FULL_NETWORK	MSH2 BRCA1 WRN	2.97e-03	120	34	3	M40049
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	CES3 CLTC	3.02e-03	34	34	2	MM15566
Pathway	REACTOME_INTERFERON_ALPHA_BETA_SIGNALING	STAT2 IFNAR1	3.02e-03	34	34	2	MM15631
Pathway	WP_CYTOKINECYTOKINE_RECEPTOR_INTERACTION	CCL5 CCL18 CXCL12 IFNAR1	3.12e-03	254	34	4	M48344
Pathway	KEGG_PRION_DISEASES	CCL5 C7	3.20e-03	35	34	2	M13036
Pathway	REACTOME_EVASION_BY_RSV_OF_HOST_INTERFERON_RESPONSES	STAT2 IFNAR1	3.20e-03	35	34	2	M48246
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BRCA1 WRN	3.20e-03	35	34	2	MM15293
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	BRCA1 WRN	3.38e-03	36	34	2	MM15281
Pathway	WP_OVERVIEW_OF_PROINFLAMMATORY_AND_PROFIBROTIC_MEDIATORS	CCL5 CCL18 CXCL12	3.48e-03	127	34	3	M42533
Pathway	REACTOME_PLASMA_LIPOPROTEIN_CLEARANCE	CES3 CLTC	3.57e-03	37	34	2	M27847
Pathway	WP_INTERFERONMEDIATED_SIGNALING	STAT2 IFNAR1	3.57e-03	37	34	2	M39785
Pathway	REACTOME_RESOLUTION_OF_D_LOOP_STRUCTURES	BRCA1 WRN	3.57e-03	37	34	2	M27583
Pathway	REACTOME_HDR_THROUGH_SINGLE_STRAND_ANNEALING_SSA	BRCA1 WRN	3.57e-03	37	34	2	M27568
Pathway	KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	CCL5 CCL18 CXCL12 IFNAR1	3.58e-03	264	34	4	M9809
Pathway	WP_PLEURAL_MESOTHELIOMA	CCL5 CHD8 TCF7L2 BRCA1 CXCL12	3.78e-03	439	34	5	M42563
Pathway	REACTOME_MITF_M_REGULATED_MELANOCYTE_DEVELOPMENT	EPRS1 TCF7L2	3.96e-03	39	34	2	MM17226
Pathway	WP_IMMUNE_INFILTRATION_IN_PANCREATIC_CANCER	CCL5 CXCL12	3.96e-03	39	34	2	M46456
Pubmed	Specific induction of macrophage inflammatory protein 1-alpha in glial cells of Sandhoff disease model mice associated with accumulation of N-acetylhexosaminyl glycoconjugates.	CCL5 CCL18 CXCL12	3.55e-07	11	46	3	15748167
Pubmed	Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production.	CCL5 CCL18 CXCL12	7.80e-07	14	46	3	25595646
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ADNP2 CHD8 SCAF11 CHD2 MSH2 TCF7L2 BRCA1 WRN	1.21e-06	608	46	8	36089195
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	CHD2 MSH2 SMC2 CLTC WRN	1.66e-06	150	46	5	30154076
Pubmed	Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis.	CCL5 CXCL12	1.71e-06	2	46	2	19342158
Pubmed	Esophageal cancer risk is associated with polymorphisms of DNA repair genes MSH2 and WRN in Chinese population.	MSH2 WRN	1.71e-06	2	46	2	22173703
Pubmed	CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.	CCL5 CCL18	1.71e-06	2	46	2	17909104
Pubmed	Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1.	CHD2 SYNGAP1	1.71e-06	2	46	2	23708187
Pubmed	Negative regulation of the Wnt-beta-catenin pathway by the transcriptional repressor HBP1.	HBP1 TCF7L2	1.71e-06	2	46	2	11500377
Pubmed	Interaction of the transcriptional activator Stat-2 with the type I interferon receptor.	STAT2 IFNAR1	1.71e-06	2	46	2	7559568
Pubmed	Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.	STAT2 IFNAR1	1.71e-06	2	46	2	9677371
Pubmed	Lack of association between RANTES-28, SDF-1 gene polymorphisms and systemic lupus erythematosus in the Malaysian population.	CCL5 CXCL12	1.71e-06	2	46	2	22095608
Pubmed	WRN loss induces switching of telomerase-independent mechanisms of telomere elongation.	BRCA1 WRN	1.71e-06	2	46	2	24709898
Pubmed	Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex.	HBP1 TCF7L2	1.71e-06	2	46	2	23613959
Pubmed	MSH2 is the very young onset ovarian cancer predisposition gene, not BRCA1.	MSH2 BRCA1	1.71e-06	2	46	2	36894311
Pubmed	Polymorphisms of TCF7L2 and HHEX genes in Chinese women with polycystic ovary syndrome.	HHEX TCF7L2	1.71e-06	2	46	2	20041287
Pubmed	Misbalanced CXCL12 and CCL5 Chemotactic Signals in Vitiligo Onset and Progression.	CCL5 CXCL12	1.71e-06	2	46	2	28132854
Pubmed	Is the association between insulin resistance and diabetogenic haematopoietically expressed homeobox (HHEX) polymorphism (rs1111875) affected by polycystic ovary syndrome status?	HHEX TCF7L2	1.71e-06	2	46	2	26563606
Pubmed	C-terminal engineering of CXCL12 and CCL5 chemokines: functional characterization by electrophysiological recordings.	CCL5 CXCL12	1.71e-06	2	46	2	24498095
Pubmed	An Immunocompetent Mouse Model of Zika Virus Infection.	STAT2 IFNAR1	1.71e-06	2	46	2	29746837
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPRS1 CHD8 SCAF11 MSH2 SMC2 CLTC	4.91e-06	332	46	6	32786267
Pubmed	Affinity of Stat2 for the subunits of the interferon alpha receptor.	STAT2 IFNAR1	5.13e-06	3	46	2	12220192
Pubmed	An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages.	STAT2 IFNAR1	5.13e-06	3	46	2	25024400
Pubmed	Expressions of CXCL12, CXCL10 and CCL18 in Warthin tumors characterized pathologically by having a lymphoid stroma with germinal centers.	CCL18 CXCL12	5.13e-06	3	46	2	34124768
Pubmed	Viruses evade the immune system through type I interferon-mediated STAT2-dependent, but STAT1-independent, signaling.	STAT2 IFNAR1	5.13e-06	3	46	2	15723812
Pubmed	Exceptions to the rule: case studies in the prediction of pathogenicity for genetic variants in hereditary cancer genes.	MSH2 BRCA1	5.13e-06	3	46	2	25639900
Pubmed	Wild-type BRCA1, but not mutated BRCA1, regulates the expression of the nuclear form of beta-catenin.	CHD8 BRCA1	5.13e-06	3	46	2	20215423
Pubmed	Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2).	TCF7L2 CXCL12	5.13e-06	3	46	2	19468708
Pubmed	Immune response in Stat2 knockout mice.	STAT2 IFNAR1	5.13e-06	3	46	2	11163195
Pubmed	Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts.	PTN CXCL12	5.13e-06	3	46	2	15840658
Pubmed	Stat2 binding to the interferon-alpha receptor 2 subunit is not required for interferon-alpha signaling.	STAT2 IFNAR1	5.13e-06	3	46	2	11786546
Pubmed	MCP-1, RANTES, and SDF-1 polymorphisms in Mexican patients with systemic lupus erythematosus.	CCL5 CXCL12	5.13e-06	3	46	2	18191726
Pubmed	Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists.	BRCA1 WRN	5.13e-06	3	46	2	17764108
Pubmed	Type I interferon limits mast cell-mediated anaphylaxis by controlling secretory granule homeostasis.	STAT2 IFNAR1	5.13e-06	3	46	2	31730616
Pubmed	Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.	STAT2 IFNAR1	5.13e-06	3	46	2	19561067
Pubmed	The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders.	CCL5 CXCL12	5.13e-06	3	46	2	25560580
Pubmed	RANTES, MDC and SDF-1alpha, prevent the HIVgp120-induced food and water intake decrease in rats.	CCL5 CXCL12	5.13e-06	3	46	2	16343773
Pubmed	Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.	STAT2 IFNAR1	5.13e-06	3	46	2	35708626
Pubmed	Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links.	BRCA1 WRN	5.13e-06	3	46	2	16714450
Pubmed	Synaptic release of CCL5 storage vesicles triggers CXCR4 surface expression promoting CTL migration in response to CXCL12.	CCL5 CXCL12	5.13e-06	3	46	2	25305322
Pubmed	HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium.	CCL5 CXCL12	5.13e-06	3	46	2	19661268
Pubmed	STAT2 is involved in the pathogenesis of psoriasis by promoting CXCL11 and CCL5 production by keratinocytes.	CCL5 STAT2	5.13e-06	3	46	2	28472186
Pubmed	Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.	CCL5 CXCL12	5.13e-06	3	46	2	17038526
Pubmed	A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women.	BRCA1 WRN	5.13e-06	3	46	2	19205873
Pubmed	DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.	WRN IFNAR1	5.13e-06	3	46	2	25921537
Pubmed	[Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].	CCL5 CXCL12	5.13e-06	3	46	2	22490648
Pubmed	Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs.	STAT2 IFNAR1	5.13e-06	3	46	2	26019270
Pubmed	Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.	CHD8 CHD2	5.13e-06	3	46	2	30277262
Pubmed	Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes.	CCL5 CCL18	5.13e-06	3	46	2	23029252
Pubmed	Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.	HHEX TCF7L2	5.13e-06	3	46	2	19053027
Pubmed	Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.	CCL5 CCL18 IFNAR1	5.51e-06	26	46	3	19006696
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	EPRS1 SCAF11 CHD2 MSH2 TCF7L2 RBM28 SMC2 BRCA1 INTS2 WRN	5.90e-06	1294	46	10	30804502
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MROH7 EPRS1 MSH2 CLTC WRN	7.10e-06	202	46	5	33005030
Pubmed	TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.	MSH2 SMC2 BRCA1	9.48e-06	31	46	3	26095369
Pubmed	Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.	STAT2 IFNAR1	1.03e-05	4	46	2	23653476
Pubmed	Species-Specific Pathogenicity of Severe Fever with Thrombocytopenia Syndrome Virus Is Determined by Anti-STAT2 Activity of NSs.	STAT2 IFNAR1	1.03e-05	4	46	2	30814285
Pubmed	[Association analysis of genetic polymorphisms of TCF7L2, CDKAL1, SLC30A8, HHEX genes and microvascular complications of type 2 diabetes mellitus].	HHEX TCF7L2	1.03e-05	4	46	2	22487833
Pubmed	TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.	STAT2 IFNAR1	1.03e-05	4	46	2	33811647
Pubmed	The rate of the predominant Jewish mutations in the BRCA1, BRCA2, MSH2 and MSH6 genes in unselected Jewish endometrial cancer patients.	MSH2 BRCA1	1.03e-05	4	46	2	20850175
Pubmed	Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.	CCL5 CXCL12	1.03e-05	4	46	2	9826729
Pubmed	Zika virus spreads through infection of lymph node-resident macrophages.	STAT2 IFNAR1	1.03e-05	4	46	2	36795561
Pubmed	Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.	STAT2 IFNAR1	1.03e-05	4	46	2	15964802
Pubmed	STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor.	STAT2 IFNAR1	1.03e-05	4	46	2	21379341
Pubmed	IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.	STAT2 IFNAR1	1.03e-05	4	46	2	10490982
Pubmed	Analysis of CCR5, CCR2, SDF1 and RANTES gene polymorphisms in subjects with HIV-related PML and not determined leukoencephalopathy.	CCL5 CXCL12	1.03e-05	4	46	2	17560067
Pubmed	Hereditary ovarian carcinoma: heterogeneity, molecular genetics, pathology, and management.	MSH2 BRCA1	1.03e-05	4	46	2	19383374
Pubmed	Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C.	CCL5 CXCL12	1.03e-05	4	46	2	12557141
Pubmed	A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.	PTN CXCL12	1.03e-05	4	46	2	19672298
Pubmed	Impaired type I IFN-induced Jak/STAT signaling in FA-C cells and abnormal CD4+ Th cell subsets in Fancc-/- mice.	STAT2 IFNAR1	1.03e-05	4	46	2	15356134
Pubmed	Effect of lysine to arginine mutagenesis in the V3 loop of HIV-1 gp120 on viral entry efficiency and neutralization.	CCL5 CXCL12	1.03e-05	4	46	2	25785610
Pubmed	Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines.	CCL5 CXCL12	1.03e-05	4	46	2	10872839
Pubmed	CCR5, RANTES and SDF-1 polymorphisms and mother-to-child HIV-1 transmission.	CCL5 CXCL12	1.03e-05	4	46	2	20518834
Pubmed	RANTES -28G delays and DC-SIGN - 139C enhances AIDS progression in HIV type 1-infected Japanese hemophiliacs.	CCL5 CXCL12	1.03e-05	4	46	2	17530998
Pubmed	Use of chemokine receptors by poxviruses.	CCL5 CXCL12	1.03e-05	4	46	2	10583963
Pubmed	Predictive value of MGMT, hMLH1, hMSH2 and BRCA1 protein expression for pathological complete response to neoadjuvant chemotherapy in basal-like breast cancer patients.	MSH2 BRCA1	1.03e-05	4	46	2	22083523
Pubmed	Association of RANTES G-403A gene polymorphism with increased risk of coronary arteriosclerosis.	CCL5 CXCL12	1.03e-05	4	46	2	15302103
Pubmed	Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut.	BRCA1 WRN	1.03e-05	4	46	2	16738949
Pubmed	The risk allele load accelerates the age-dependent decline in beta cell function.	HHEX TCF7L2	1.03e-05	4	46	2	19172244
Pubmed	ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes.	STAT2 IFNAR1	1.03e-05	4	46	2	30517866
Pubmed	A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India.	HHEX TCF7L2	1.03e-05	4	46	2	20597906
Pubmed	Association of genetic variations in TCF7L2, SLC30A8, HHEX, LOC387761, and EXT2 with Type 2 diabetes mellitus in Tunisia.	HHEX TCF7L2	1.03e-05	4	46	2	21510814
Pubmed	Lack of association of some chemokine system polymorphisms with the risks of death and hepatocellular carcinoma occurrence in patients with alcoholic cirrhosis: a prospective study.	CCL5 CXCL12	1.03e-05	4	46	2	17413295
Pubmed	Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.	STAT2 IFNAR1	1.03e-05	4	46	2	9121453
Pubmed	Functional Impacts of the BRCA1-mTORC2 Interaction in Breast Cancer.	MAPKAP1 BRCA1	1.03e-05	4	46	2	31771139
Pubmed	Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.	MSH2 BRCA1 WRN	1.50e-05	36	46	3	18830263
Pubmed	Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.	HHEX TCF7L2	1.71e-05	5	46	2	19368707
Pubmed	Gene polymorphisms in CCR5, CCR2, CX3CR1, SDF-1 and RANTES in exposed but uninfected partners of HIV-1 infected individuals in North India.	CCL5 CXCL12	1.71e-05	5	46	2	16865553
Pubmed	Role of the chemokines CCL3/MIP-1 alpha and CCL5/RANTES in sponge-induced inflammatory angiogenesis in mice.	CCL5 CCL18	1.71e-05	5	46	2	19427874
Pubmed	No association between common chemokine and chemokine receptor gene variants and prostate cancer risk.	CCL5 CXCL12	1.71e-05	5	46	2	19064579
Pubmed	Type I IFN signaling facilitates the development of IL-10-producing effector CD8+ T cells during murine influenza virus infection.	STAT2 IFNAR1	1.71e-05	5	46	2	27701741
Pubmed	IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners.	STAT2 IFNAR1	1.71e-05	5	46	2	31619669
Pubmed	Genetic control of chemokines in severe human internal carotid artery stenosis.	CCL5 CXCL12	1.71e-05	5	46	2	18060801
Pubmed	IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.	STAT2 IFNAR1	1.71e-05	5	46	2	24760883
Pubmed	gp120 induces cell death in human neuroblastoma cells through the CXCR4 and CCR5 chemokine receptors.	CCL5 CXCL12	1.71e-05	5	46	2	10820198
Pubmed	Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors.	MSH2 WRN	1.71e-05	5	46	2	17715146
Pubmed	Age-Dependent Effects of Type I and Type III IFNs in the Pathogenesis of Bordetella pertussis Infection and Disease.	STAT2 IFNAR1	1.71e-05	5	46	2	32152071
Pubmed	Chemokine polymorphisms and lymphoma: a pooled analysis.	CCL5 CXCL12	1.71e-05	5	46	2	20038229
Pubmed	Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative individuals repeatedly exposed to HIV-1.	CCL5 CXCL12	1.71e-05	5	46	2	15319853
Pubmed	High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells.	STAT2 IFNAR1	1.71e-05	5	46	2	17846149
Pubmed	Comparison of chemokines (CCL-5 and SDF-1), chemokine receptors (CCR-5 and CXCR-4) and IL-6 levels in patients with different severities of depression.	CCL5 CXCL12	1.71e-05	5	46	2	25150002
Interaction	H3-3A interactions	ADNP2 EPRS1 CHD8 SCAF11 CHD2 MSH2 TCF7L2 BRCA1 BRWD3 WRN	4.64e-06	749	45	10	int:H3-3A
Interaction	SUMO2 interactions	EPRS1 CHD8 SCAF11 MSH2 SMC2 BRCA1 ZMYM5 CLTC WRN	5.21e-06	591	45	9	int:SUMO2
Interaction	CHEK2 interactions	CCL5 MSH2 RBM28 SMC2 BRCA1 WRN	1.86e-05	250	45	6	int:CHEK2
GeneFamily	Chemokine ligands\|Endogenous ligands	CCL5 CCL18 CXCL12	1.06e-04	45	37	3	483
GeneFamily	Endogenous ligands	PTN CCL5 CXCL12	1.24e-02	237	37	3	542
Coexpression	YAN_ESCAPE_FROM_ANOIKIS	CCL5 RSAD2 STAT2	8.74e-06	23	46	3	M1221
Coexpression	HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN	CXCL12 STAT2 IFNAR1	8.74e-06	23	46	3	M12153
Coexpression	QI_PBMC_ZOSTAVAX_AGE_50_75YO_CORRELATED_WITH_28D_PEAK_T_CELL_RESPONSE_14DY_NEGATIVE	MSH2 SMC2 BRCA1	3.77e-05	37	46	3	M41132
Coexpression	CHICAS_RB1_TARGETS_CONFLUENT	PTN GMDS HHEX C7 BEND6 GASK1B CXCL12	5.50e-05	567	46	7	M2129
Coexpression	CHICAS_RB1_TARGETS_GROWING	PTN MSH2 SMC2 GASK1B CXCL12	6.48e-05	242	46	5	M2128
Coexpression	MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6	SCAF11 SMC2 STAT2	7.77e-05	47	46	3	M1652
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_500	CHD8 CHD2 SMC2 INTS2 BRWD3 CXCL12 IFNAR1	2.19e-05	417	44	7	gudmap_developingGonad_e11.5_ovary + mesonephros_500
CoexpressionAtlas	DevelopingGonad_e12.5_ovary_emap-28876_top-relative-expression-ranked_1000	PTN CHD8 SCAF11 CHD2 SMC2 INTS2 GASK1B BRWD3 IFNAR1	3.29e-05	804	44	9	gudmap_developingGonad_e12.5_ovary_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000	TDRD5 CHD8 SCAF11 CHD2 TCF7L2 SMC2 BRCA1 GASK1B IFNAR1	3.36e-05	806	44	9	gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlas	DevelopingGonad_e11.5_ovary + mesonephros_emap-3226_top-relative-expression-ranked_1000	PTN CHD8 SCAF11 CHD2 SMC2 INTS2 BRWD3 CXCL12 IFNAR1	3.66e-05	815	44	9	gudmap_developingGonad_e11.5_ovary + mesonephros_1000
CoexpressionAtlas	DevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000	TDRD5 GMDS HBP1 CHD8 SCAF11 SMC2 DNAH8 IFNAR1	1.61e-04	770	44	8	gudmap_developingGonad_P2_ovary_1000
CoexpressionAtlas	DevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_500	CHD8 SCAF11 CHD2 SMC2 GASK1B IFNAR1	1.73e-04	403	44	6	gudmap_developingGonad_e12.5_epididymis_500
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1	SCAF11 CHD2 TCF7L2 SMC2 BRCA1 ZMYM5 IFNAR1 SYNGAP1	1.75e-04	780	44	8	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_500	PTN CHD8 SCAF11 CHD2 SMC2 IFNAR1	1.97e-04	413	44	6	gudmap_developingGonad_e14.5_ epididymis_500
CoexpressionAtlas	DevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000	TDRD5 CHD8 SCAF11 CHD2 SMC2 INTS2 DNAH8 IFNAR1	2.00e-04	795	44	8	gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	TDRD5 GMDS GPSM2 HHEX MSH2 SNAPC1 BRCA1 DNAH8	2.46e-04	820	44	8	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#3	SCAF11 CHD2 SMC2 BRCA1 ZMYM5	3.27e-04	291	44	5	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000_K3
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN EPRS1 C7 GASK1B CXCL12	1.64e-06	193	46	5	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 GASK1B CXCL12 STAT2	2.03e-05	156	46	4	0695ac0f02d059ecf813d61d3c9d4c76d1d85834
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 GASK1B CXCL12 STAT2	2.03e-05	156	46	4	1c2920f4356789a9c11d5ea1eaafb18a50b19ed7
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RSAD2 GASK1B CXCL12 STAT2	2.03e-05	156	46	4	a45fbe02cd03bd4a097f21368bc1179779ba0db8
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	3.11e-05	174	46	4	9d22a554617a93701d0945de63cc3e7b24322c40
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	CHD8 CHD2 RSAD2 STAT2	3.78e-05	183	46	4	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTN C7 GASK1B CXCL12	4.20e-05	188	46	4	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	4.56e-05	192	46	4	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	4.65e-05	193	46	4	96c85b250d04b5f400512097d925061c6dc2906b
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	ADNP2 GPSM2 SMC2 BRCA1	4.65e-05	193	46	4	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7L2 BEND6 SMC2 BRCA1	4.75e-05	194	46	4	effd38e51062b225ecabc7e1c50154e65495d559
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCL5 SMC2 BRCA1 INTS2	4.75e-05	194	46	4	5031f324628ff12a33e84cc52157be4786e0961d
ToppCell	control-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HHEX RSAD2 GASK1B STAT2	4.84e-05	195	46	4	19413dc6aa0010686cdfa0c750ef0a7a76caf308
ToppCell	COVID-19-Heart-Low_count_Fib\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTN C7 GASK1B CXCL12	4.84e-05	195	46	4	e09590d1f51d5fa57fceb84c9f48f84b23d4d224
ToppCell	Control-Lymphoid-Proliferating_CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	GPSM2 TCF7L2 CCL18 BRCA1	4.84e-05	195	46	4	578bbb06a5476c08fc3b351cc580c551dfe53ae4
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	PTN TCF7L2 C7 CXCL12	4.94e-05	196	46	4	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	5.14e-05	198	46	4	9541d68a1a6247dbd7161a62644eea6527c2c8ff
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	5.14e-05	198	46	4	0f4052a59c6bd89dab637d6ef1214460d6cbcf55
ToppCell	Non-neuronal-Dividing-IPC-IPC-new\|World / Primary Cells by Cluster	PTN SCAF11 SMC2 BRCA1	5.14e-05	198	46	4	11d2d4d179bc31ef2897d7ceeaf9bed1b20cbdc0
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	5.14e-05	198	46	4	12cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCell	Non-neuronal-Dividing-IPC-IPC-new-9\|World / Primary Cells by Cluster	PTN SCAF11 SMC2 BRCA1	5.14e-05	198	46	4	c724ef958e14e17a7d8c02b9f842510c0780f635
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	5.14e-05	198	46	4	7582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell	Parenchyma_COVID-19\|World / Sample group, Lineage and Cell type	C7 BEND6 GASK1B CXCL12	5.14e-05	198	46	4	45ab554e6d0399b3182f089a25b2adf96de1144b
ToppCell	Skin-Endothelial\|Skin / Skin and Kidney Cells in Lupus Nephritis Patients.	HHEX RSAD2 GASK1B CXCL12	5.24e-05	199	46	4	6b3ef5d8f87cdfe5401d05f19339ddfcd9cda476
ToppCell	ILEUM-non-inflamed-(8)_Fibroblasts\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PTN C7 GASK1B CXCL12	5.24e-05	199	46	4	d9d7f36b4b5592b7855448730044c90997b55499
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PTN C7 GASK1B CXCL12	5.24e-05	199	46	4	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	3'-Child09-12-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 GASK1B CXCL12	5.24e-05	199	46	4	36883044787a9fb79cf7e83a7da8e34eea83f2f1
ToppCell	ILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts\|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PTN C7 GASK1B CXCL12	5.24e-05	199	46	4	56d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells-Neuroepithelial_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	PTN GPSM2 SMC2 BRCA1	5.34e-05	200	46	4	c865efaaaecccbf9c833d6c1cbe85809a3ec306d
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Stem_cells\|5w / Sample Type, Dataset, Time_group, and Cell type.	PTN GPSM2 SMC2 BRCA1	5.34e-05	200	46	4	2ee167b8bddd11fd5b1f61f87fcdf757aee3193e
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SCAF11 CHD2 RSAD2 STAT2	5.34e-05	200	46	4	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	C7 SMC2 IFNAR1	4.23e-04	142	46	3	0e0f8bb956ff89dc98e8fa56f8acac33e01a26dd
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 CXCL12	4.96e-04	150	46	3	909ccab92855f5f049dc29593aadab1ea973297b
ToppCell	368C-Fibroblasts-Fibroblast-H-\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPSM2 BEND6 SYNGAP1	5.16e-04	152	46	3	dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCell	368C-Fibroblasts-Fibroblast-H\|368C / Donor, Lineage, Cell class and subclass (all cells)	GPSM2 BEND6 SYNGAP1	5.16e-04	152	46	3	9f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCTD21 C7 CXCL12	5.26e-04	153	46	3	d5f5399ebbbff508c96ce7f01272716b61597ab5
ToppCell	343B-Epithelial_cells-Epithelial-E_(AT2)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	KCTD21 C7 CXCL12	5.26e-04	153	46	3	32cf4ca828d228f23366480305592f9813fed7ff
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	C7 BEND6 CXCL12	5.46e-04	155	46	3	e1a20e88b9c0eaf7ca7004acc0eda096d1588563
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	RBM28 BRCA1 MYO1A	5.56e-04	156	46	3	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TDRD5 CCL5 BEND6	5.99e-04	160	46	3	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MROH7 ZNF396 KCTD21	6.32e-04	163	46	3	961c3a1303108afd680365466045f3460a30a7b0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTN C7 CXCL12	6.43e-04	164	46	3	01a7c335897128d3478b8b9b44fb461cab493084
ToppCell	lung-Club_Cells\|lung / shred on tissue and cell subclass	PTN GMDS HHEX	6.43e-04	164	46	3	b12cacd499b18b96120ca6d14646aebeaed41d10
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	EPRS1 CCL5 WRN	6.66e-04	166	46	3	ceb0a48c0d853448fd45ac31dde046df9a178571
ToppCell	systemic_lupus_erythematosus-flare-Hematopoietic-Progen-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CHD8 MSH2 MYO1A	6.78e-04	167	46	3	b89ebd4906f52b1fe6b6540ec9339284e7caddd2
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TCF7L2 SMC2 WRN	6.90e-04	168	46	3	52fd65024af8683db11d931f7563cbe8eb815d1c
ToppCell	PND03-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BEND6 SMC2 BRCA1	7.02e-04	169	46	3	a1efc20e34a81ae32f8d278a5486811ade03ef24
ToppCell	droplet-Kidney-nan-3m-Lymphocytic-CD45____B_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHEX CHD2 DNAH8	7.14e-04	170	46	3	6210ee3bf29059e6149c047bb7e02c5f59441519
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	GPSM2 MSH2 SMC2	7.26e-04	171	46	3	b113fbebb89056af0b9c775d2fb6552206a80467
ToppCell	wk_20-22-Mesenchymal-Chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PTN SCN11A RSAD2	7.26e-04	171	46	3	d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTN KCTD21 C7	7.26e-04	171	46	3	2a34685f7d83d1cf9a88d304173cbca868c5f9fd
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCL5 BEND6 SMC2	7.26e-04	171	46	3	846a9acfff0bf0a9baf65dc07b7d7a9217ed6598
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CFAP47 TDRD5 ADGRG4	7.51e-04	173	46	3	46ed379571385684145b5cb6dd4ae340ac546e64
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GMDS EPRS1 CXCL12	7.51e-04	173	46	3	7a3115e7cf7e2f345192cde0656a7f0193594a5f
ToppCell	343B-Fibroblasts-Fibroblast-H-\|343B / Donor, Lineage, Cell class and subclass (all cells)	C7 BEND6 CXCL12	7.64e-04	174	46	3	2627c3983009839fedbc5e3f628739dc026447f4
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PTN GPSM2 SMC2	7.64e-04	174	46	3	46cbb462173a684ceb9e680f9259dc3b133763f7
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HHEX SCN11A GASK1B	7.64e-04	174	46	3	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	343B-Fibroblasts-Fibroblast-H\|343B / Donor, Lineage, Cell class and subclass (all cells)	C7 BEND6 CXCL12	7.64e-04	174	46	3	507a33e58f62e2b72f0bcc743e84dbd0bf705a15
ToppCell	356C-Myeloid-Macrophage-FABP4+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	C7 BEND6 CXCL12	7.89e-04	176	46	3	bfa1633e1b7a8a2f04d37fa07284fe9bc0199f46
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KLF18 TCF7L2 BEND6	7.89e-04	176	46	3	b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCell	(01)_Cycling_Basal_(homeostasis)\|World / shred by cell type and Timepoint	PTN GPSM2 SMC2	8.02e-04	177	46	3	05c57578142a6662f18b294d5cc11e6efd6b0f8e
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PTN GPSM2 SMC2	8.02e-04	177	46	3	4197cf2b1e743230c821f422836fa5991b155a52
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_3\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF396 INTS2 WRN	8.16e-04	178	46	3	9d575902d3dbe33437c9d4200df093a741269803
ToppCell	droplet-Lung-nan-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GMDS TCF7L2 BEND6	8.16e-04	178	46	3	de6cd81e6d58e7687386df163471bf1901b9c0aa
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCAF11 RSAD2 C7	8.16e-04	178	46	3	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	Endothelial\|World / shred by cell class for turbinate	C7 GASK1B CXCL12	8.29e-04	179	46	3	052b2681974be00efb8503fa4e2c85d91d5ebd06
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCL5 C7 CXCL12	8.29e-04	179	46	3	b70509288aaf4457afd350f6c45784521337ce0d
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTN C7 CXCL12	8.42e-04	180	46	3	ea7a1ccf0dd3bb5af5df87501f873e7339a824b3
ToppCell	facs-Bladder-nan-24m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCL5 CXCL12 STAT2	8.42e-04	180	46	3	12537d8a569faa69f474284d2c201475722b8ca1
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GPSM2 C7 CXCL12	8.56e-04	181	46	3	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-5\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ADNP2 GMDS TCF7L2	8.56e-04	181	46	3	8fcc9e77fee7c248df26b6c59b10e672242e2084
ToppCell	facs-Marrow-B-cells-18m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7L2 STAT2 IFNAR1	8.56e-04	181	46	3	782716b8b1d447d2bbe09a693fa5ed7ebeac0efb
ToppCell	facs-Marrow-B-cells-18m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7L2 STAT2 IFNAR1	8.56e-04	181	46	3	e2481291c236105774c53883e6f20da11941df9b
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	C7 GASK1B CXCL12	8.70e-04	182	46	3	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)\|390C / Donor, Lineage, Cell class and subclass (all cells)	C7 ADGRG4 CXCL12	8.84e-04	183	46	3	28e1fc6498aaf8f42c4d6d4fa54ffff4c546d0d1
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	GPSM2 SMC2 BRCA1	8.84e-04	183	46	3	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	B_cells-ISG-high_B_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RSAD2 DNAH8 STAT2	8.84e-04	183	46	3	dc2b00e920efa1dcc2a6265cd1024e3249c9974f
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HHEX C7 GASK1B	8.84e-04	183	46	3	a644258ba90acc62d571623e429d72ffc4b69203
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PTN SCN11A RSAD2	8.84e-04	183	46	3	1464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GMDS TCF7L2 BRCA1	8.84e-04	183	46	3	42dc31d587fbb9724b2f0be5ee8ed77233f67b86
ToppCell	Control-T/NK_proliferative\|Control / Disease group and Cell class	GPSM2 SMC2 BRCA1	8.84e-04	183	46	3	09c2b4e630f1c338f02c1242e3598e870d6b0a28
ToppCell	390C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	C7 ADGRG4 CXCL12	8.84e-04	183	46	3	667d9107af17fd076ceff6b2cbcb78f892fd62d2
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HHEX BRCA1 GASK1B	8.98e-04	184	46	3	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	IIF-Lymphocyte-T_NK-T_NK_proliferative\|IIF / Disease, Lineage and Cell Type	CCL18 SMC2 BRCA1	8.98e-04	184	46	3	ab8b45ce40e8c5f66e5c23332a591b4f9cba4ce1
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPRS1 CLTC IFNAR1	8.98e-04	184	46	3	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TCF7L2 BEND6 SMC2	8.98e-04	184	46	3	16aa8e88bdd51b1d132d5cf33c29963b384a8bae
ToppCell	Control-CD8+_T_activated\|Control / Disease group and Cell class	RSAD2 KCTD21 STAT2	8.98e-04	184	46	3	b86cc48b744b3206880ec1373fe6068e14bf9680
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CCL5 SMC2 BRCA1	8.98e-04	184	46	3	8260e688ec42a1374727bc85dceb7edd19a8b662
ToppCell	droplet-Lung-3m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GMDS SMC2 BRCA1	9.12e-04	185	46	3	57c1eb50a4456d20953e48d5dc3b0ea3d0d81b6d
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTN C7 GASK1B	9.12e-04	185	46	3	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-proliferating_alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TCF7L2 BEND6 SMC2	9.12e-04	185	46	3	b4af9ae4c358b48357cb135b740266e1652d886a
ToppCell	Endothelial-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	HHEX C7 CXCL12	9.12e-04	185	46	3	dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCell	10x5'-bone_marrow-Myeloid_Dendritic-Cycling_Dendritic\|bone_marrow / Manually curated celltypes from each tissue	BEND6 SMC2 BRCA1	9.12e-04	185	46	3	9d3168c7f0b1d739f78b368969cf5c77ce202b97
ToppCell	facs-Skin-Telogen-3m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMC2 BRCA1 DNAH8	9.26e-04	186	46	3	9feef5936985e936b3d88f9d1bb012abb6468570
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HHEX SCN11A GASK1B	9.26e-04	186	46	3	055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PTN GMDS CXCL12	9.26e-04	186	46	3	b5c1afbe065746ed662527b2f052321f200ba0a8
ToppCell	facs-BAT-Fat-24m-Epithelial-Epcam+\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTN GMDS BRWD3	9.26e-04	186	46	3	b18d7398279a2d42414318aeb70514fd402f5a0a
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|bone_marrow / Manually curated celltypes from each tissue	SMC2 BRCA1 GASK1B	9.26e-04	186	46	3	e82d5e7a976b9cfa2b4640c7a7cd1cfea19c4806
ToppCell	Dividing_Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	GPSM2 CCL18 SMC2	9.26e-04	186	46	3	0067eb78d4c7e32b9563550d9fcaf13445ee6a48
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PTN C7 CXCL12	9.26e-04	186	46	3	7582b5154d8e5a4434817b5ab77a10b789ea2288
Computational	Genes in the cancer module 123.	ADNP2 GPSM2 CHD2 SNAPC1 BRCA1 STAT2	7.60e-05	247	32	6	MODULE_123
Drug	testosterone enanthate	ADNP2 PTN EPRS1 GPSM2 CHD8 SCAF11 RSAD2 SNAPC1 SMC2 ZMYM5	1.76e-07	575	46	10	ctd:C004648
Disease	Adult only	MSH2 BRCA1	3.10e-05	6	43	2	C3842001
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD2	4.34e-05	7	43	2	DOID:0050834 (implicated_via_orthology)
Disease	breast cancer (is_implicated_in)	MSH2 TCF7L2 BRCA1 WRN	6.79e-05	150	43	4	DOID:1612 (is_implicated_in)
Disease	myocardial infarction (biomarker_via_orthology)	PTN CCL5 C7 CXCL12	8.71e-05	160	43	4	DOID:5844 (biomarker_via_orthology)
Disease	Macrocephaly	CHD8 BRWD3	1.13e-04	11	43	2	C0221355
Disease	Liver Cirrhosis, Experimental	CES3 PTN CCL5 C7 SMC2 GASK1B CXCL12	1.18e-04	774	43	7	C0023893
Disease	psoriasis, type 2 diabetes mellitus	HHEX TCF7L2 STAT2	1.81e-04	75	43	3	EFO_0000676, MONDO_0005148
Disease	–	CCL5 CXCL12	2.46e-04	16	43	2	609423
Disease	Susceptibility to HIV infection	CCL5 CXCL12	2.46e-04	16	43	2	cv:C1836230
Disease	Neurodevelopmental Disorders	CHD2 TCF7L2 SYNGAP1	3.41e-04	93	43	3	C1535926
Disease	Intellectual Disability	CHD8 RBM28 BRCA1 BRWD3 SYNGAP1	4.67e-04	447	43	5	C3714756
Disease	colorectal cancer (is_implicated_in)	MSH2 TCF7L2 BRCA1	7.36e-04	121	43	3	DOID:9256 (is_implicated_in)
Disease	hepatitis C (is_implicated_in)	CCL5 IFNAR1	7.65e-04	28	43	2	DOID:1883 (is_implicated_in)
Disease	Neoplasm of uncertain or unknown behavior of ovary	MSH2 BRCA1	8.21e-04	29	43	2	C0496920
Disease	anti-basement membrane glomerulonephritis (biomarker_via_orthology)	CCL5 CXCL12	8.79e-04	30	43	2	DOID:4780 (biomarker_via_orthology)
Disease	Ovarian Carcinoma	MSH2 BRCA1	8.79e-04	30	43	2	C0029925
Disease	Epileptic encephalopathy	CHD2 SYNGAP1	8.79e-04	30	43	2	C0543888
Disease	Breast Cancer, Familial	MSH2 BRCA1	8.79e-04	30	43	2	C0346153
Disease	type 2 diabetes mellitus (is_marker_for)	CCL5 TCF7L2 CXCL12	1.03e-03	136	43	3	DOID:9352 (is_marker_for)
Disease	sensorineural hearing loss (is_implicated_in)	GPSM2 MYO1A	1.06e-03	33	43	2	DOID:10003 (is_implicated_in)
Disease	colon cancer (is_implicated_in)	MSH2 BRCA1	1.27e-03	36	43	2	DOID:219 (is_implicated_in)
Disease	autism spectrum disorder (implicated_via_orthology)	CHD8 CHD2 SYNGAP1	1.42e-03	152	43	3	DOID:0060041 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
WNCPSKKQKEPQQKI	TDRD5	406	Q8NAT2
RKQKWQRCKKNNKAE	CHD8	2361	Q9HCK8
QWEKPKFKQCKLLQE	ADGRG4	2436	Q8IZF6
QSLKCNPDAWKKQCK	BRWD3	1296	Q6RI45
GRQICADPNKKWVQK	CCL18	66	P55774
IEKWQIARCNKSKPQ	BEND6	176	Q5SZJ8
VLKQAKQWKTCPVCN	ADNP2	686	Q6IQ32
RKPWDNQQQTVAKIC	MROH7	1171	Q68CQ1
KPKPQINQWKQEKQQ	RBM28	696	Q9NW13
KTQRCKIPCNWKKQF	PTN	81	P21246
KVQNWNSEILAKQKP	GPSM2	421	P81274
TKQNLKRLWVVPANK	KCTD21	201	Q4G0X4
CTKAKQKLNWKPRVA	GMDS	336	O60547
QWKCKRFRDQLSPKQ	MYO1A	826	Q9UBC5
KWRRLKQENPQSNKK	HHEX	191	Q03014
CQSGQKTVKPKWRNV	KIAA1109	626	Q2LD37
KWKQIPDCENVKTTQ	IFNAR1	276	P17181
QNRCRKLPKGLKDWQ	DNAH8	1316	Q96JB1
QQIKEKPSGWSQICK	INTS2	1151	Q9H0H0
QIKAFQEKQKRWQQP	FAM9A	276	Q8IZU1
KEWNKQKLPCSENPR	BRCA1	351	P38398
QQLLKQKCWQNGRVP	GASK1B	336	Q6UWH4
GQRQLKKQEKWKQEP	CHD2	141	O14647
RNNCWKEKQQKEGLL	DNAJB12	326	Q9NXW2
TQAVPKCQRWEKLQN	C7	696	P10643
TRKNRQVCANPEKKW	CCL5	66	P13501
KQKTQSCQFWKNPEV	KLF18	946	A0A0U1RQI7
AEEQKRLNPDCWKRK	HBP1	491	O60381
LPSKIQQWHQKQKNR	CES3	551	Q6UWW8
KNAAIKINKPQRSNW	SCAF11	166	Q99590
NICRWNQKIRFKEPV	CFAP47	66	Q6ZTR5
NKCKTPQGQRLVNQW	MSH2	331	P43246
NAAWQEQLKQKKAPV	EPRS1	131	P07814
EEWKAQQQKACIRAP	STAT2	236	P52630
QIKALNPVRWKVFQC	RSAD2	236	Q8WXG1
ERQNQIKCKNIQWKE	MAPKAP1	96	Q9BPZ7
IKCKNIQWKERNSKQ	MAPKAP1	101	Q9BPZ7
QQRKCPEWMNVQNKR	WRN	11	Q14191
CQPKQKIRVALKDWD	SNAPC1	91	Q16533
KGNNRWKQSVELCKK	CLTC	1516	Q00610
KWIENLQRAVKPNKD	SYNGAP1	241	Q96PV0
TCLEQNKEPWNIKRN	ZNF679	66	Q8IYX0
DQQNNWCGPCRRKKK	TCF7L2	471	Q9NQB0
KDPEKNWNRNCVKGL	SMC2	511	O95347
PCENNWNLKKGVFNK	ZMYM5	321	Q9UJ78
KWCRKQNLPQQKEVA	SCN11A	856	Q9UI33
RQGNPSWKKQQKCDE	ZNF396	241	Q96N95
NNRQVCIDPKLKWIQ	CXCL12	66	P48061