Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessSCF-dependent proteasomal ubiquitin-dependent protein catabolic process

FBXO2 FBXW5 BTRC FBXW11 FBXL17 FBXL20

8.30e-06492036GO:0031146
GeneOntologyCellularComponentSCF ubiquitin ligase complex

FBXO2 FBXW5 BTRC FBXW11 FBXL17 FBXL20

6.43e-05702056GO:0019005
GeneOntologyCellularComponentmicrotubule

MAP1B RASSF5 TUBGCP3 FBXW11 KIF26B ARFGEF2 PRC1 KLC4 CCDC57 TTLL8 ARHGAP4 MISP RADIL GOLGA8A PCNT DNAH11

7.75e-0553320516GO:0005874
GeneOntologyCellularComponentubiquitin ligase complex

KLHDC2 FBXO2 FBXW5 MED12 BTRC FBXW11 DCAF13 RNF31 WWP1 FBXL17 FBXL20 PRAMEF27

1.96e-0435220512GO:0000151
GeneOntologyCellularComponentcullin-RING ubiquitin ligase complex

KLHDC2 FBXO2 FBXW5 BTRC FBXW11 DCAF13 FBXL17 FBXL20 PRAMEF27

2.55e-042122059GO:0031461
Domain-

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 SEMA6C PLXNA3 DCAF13 WDR19 WDR11 WDCP UTP4 WDR86

6.37e-07333200162.130.10.10
DomainWD40/YVTN_repeat-like_dom

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 SEMA6C PLXNA3 DCAF13 WDR19 WDR11 WDCP UTP4 WDR86

6.89e-0733520016IPR015943
DomainWD_REPEATS_1

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 WDCP UTP4 WDR86

1.89e-0627820014PS00678
DomainWD_REPEATS_2

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 WDCP UTP4 WDR86

1.97e-0627920014PS50082
DomainWD_REPEATS_REGION

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 WDCP UTP4 WDR86

1.97e-0627920014PS50294
DomainSRCR

CD163L1 CD5 CD5L CD6 HHIPL1

2.37e-06212005PF00530
DomainWD40

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 UTP4 WDR86

4.60e-0625920013PF00400
Domain-

CD163L1 CD5 CD5L CD6 HHIPL1

5.98e-062520053.10.250.10
DomainSR

CD163L1 CD5 CD5L CD6 HHIPL1

5.98e-06252005SM00202
DomainWD40

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 UTP4 WDR86

6.66e-0626820013SM00320
DomainSRCR-like_dom

CD163L1 CD5 CD5L CD6 HHIPL1

7.34e-06262005IPR017448
DomainSRCR_1

CD163L1 CD5 CD5L CD6 HHIPL1

7.34e-06262005PS00420
DomainSRCR_2

CD163L1 CD5 CD5L CD6 HHIPL1

7.34e-06262005PS50287
DomainWD40_repeat

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 UTP4 WDR86

7.82e-0627220013IPR001680
DomainSRCR

CD163L1 CD5 CD5L CD6 HHIPL1

8.93e-06272005IPR001190
DomainWD40_repeat_dom

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 UTP4 WDR86

1.99e-0529720013IPR017986
DomainF-box

FBXO2 FBXW5 BTRC FBXW11 FBXL17 FBXL20

8.11e-05672006PF00646
DomainF-box-like

FBXW5 BTRC FBXW11 FBXL17 FBXL20

1.04e-04442005PF12937
DomainBeta-TrCP_D

BTRC FBXW11

1.14e-0422002IPR021977
DomainBeta-TrCP_D

BTRC FBXW11

1.14e-0422002PF12125
DomainBeta-TrCP_D

BTRC FBXW11

1.14e-0422002SM01028
DomainC2

INPP4A PLCB3 PKN3 RASA2 WWP1 PLCD4 SYT15B SYTL4

1.16e-041372008SM00239
DomainFBOX

FBXO2 FBXW5 BTRC FBXW11 FBXL17 FBXL20

1.21e-04722006PS50181
DomainF-box_dom

FBXO2 FBXW5 BTRC FBXW11 FBXL17 FBXL20

1.52e-04752006IPR001810
Domain-

INPP4A PLCB3 PKN3 RASA2 WWP1 PLCD4 SYT15B SYTL4

1.97e-0414820082.60.40.150
DomainTPR-contain_dom

XAB2 FANCG TTC7B PEX5 KLC4 WDR19 TMTC4 TRAPPC12

2.16e-041502008IPR013026
DomainFBOX

FBXW5 BTRC FBXW11 FBXL17 FBXL20

2.31e-04522005SM00256
DomainQuinoprot_gluc/sorb_DH

FBXW5 LRP1 HHIPL1

2.48e-04122003IPR011041
DomainG-protein_beta_WD-40_rep

TAF5 CORO7 BTRC FBXW11 WDR48 WDR86

3.03e-04852006IPR020472
DomainRA

RASSF5 RGL1 GRB10 RADIL

3.20e-04312004SM00314
DomainC2_dom

INPP4A PLCB3 PKN3 RASA2 WWP1 PLCD4 SYT15B SYTL4

3.95e-041642008IPR000008
DomainWD40_repeat_CS

TAF5 CORO7 BTRC FBXW11 WDR48 DCAF13 WDR11 WDR86

3.95e-041642008IPR019775
Domain-

ST7L XAB2 FANCG TTC7B PEX5 KLC4 WDR19 TMTC4 TRAPPC12

4.03e-0420720091.25.40.10
DomainTPR

XAB2 FANCG TTC7B PEX5 KLC4 TMTC4 TRAPPC12

4.83e-041292007SM00028
DomainRA

RASSF5 RGL1 GRB10 RADIL

5.75e-04362004PF00788
DomainTPR_repeat

XAB2 FANCG TTC7B PEX5 KLC4 TMTC4 TRAPPC12

5.80e-041332007IPR019734
DomainRA

RASSF5 RGL1 GRB10 RADIL

6.39e-04372004PS50200
DomainLys_sp_deMease-like_dom

KDM5C KDM5D

6.75e-0442002IPR013637
DomainPLU-1

KDM5C KDM5D

6.75e-0442002PF08429
DomainSec7_N

GBF1 ARFGEF2

6.75e-0442002IPR032691
DomainSec7_N

GBF1 ARFGEF2

6.75e-0442002PF12783
DomainHistone_deAcase_II_euk

HDAC4 HDAC7

6.75e-0442002IPR017320
DomainC2

INPP4A PLCB3 RASA2 WWP1 PLCD4 SYT15B SYTL4

8.55e-041422007PS50004
DomainRA_dom

RASSF5 RGL1 GRB10 RADIL

8.62e-04402004IPR000159
DomainPrtase_inh_Kunz-CS

LRIT2 PAPLN TFPI

8.77e-04182003IPR020901
DomainTPR-like_helical_dom

ST7L XAB2 FANCG TTC7B PEX5 KLC4 WDR19 TMTC4 TRAPPC12

9.41e-042332009IPR011990
Domainzf-C5HC2

KDM5C KDM5D

1.12e-0352002PF02928
DomainZnf_C5HC2

KDM5C KDM5D

1.12e-0352002IPR004198
DomainDAPIN

NLRP6 NLRP9 NLRP10

1.60e-03222003PS50824
DomainPYRIN

NLRP6 NLRP9 NLRP10

1.60e-03222003SM01289
DomainPYRIN

NLRP6 NLRP9 NLRP10

1.60e-03222003PF02758
DomainDAPIN

NLRP6 NLRP9 NLRP10

1.60e-03222003IPR004020
DomainRibokinase-like

KHK ADPGK

1.66e-0362002IPR029056
Domain-

KHK ADPGK

1.66e-03620023.40.1190.20
DomainNACHT

NLRP6 NLRP9 NLRP10

1.83e-03232003PS50837
DomainNACHT_NTPase

NLRP6 NLRP9 NLRP10

1.83e-03232003IPR007111
DomainSpectrin

ACTN2 SPTBN5 UTRN

1.83e-03232003PF00435
DomainACTININ_2

ACTN2 SPTBN5 UTRN

1.83e-03232003PS00020
DomainACTININ_1

ACTN2 SPTBN5 UTRN

1.83e-03232003PS00019
DomainActinin_actin-bd_CS

ACTN2 SPTBN5 UTRN

1.83e-03232003IPR001589
DomainTPR_REGION

FANCG TTC7B PEX5 KLC4 WDR19 TMTC4 TRAPPC12

2.03e-031652007PS50293
DomainTPR

FANCG TTC7B PEX5 KLC4 WDR19 TMTC4 TRAPPC12

2.03e-031652007PS50005
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TRPM4 GBF1 LRRC24 PCNX3 MYCBP2 SPEG INTS1 OBSCN CARD10 SFI1 PLEKHM1 MDN1 EXOSC6 OSBPL5 ARC CACNA1H DMWD MED12 MED13 PKN3 SEMA6C PLXNA3 PNPLA2 TMEM158 WWP1 ARFGEF2 GRB10 PAPLN HDAC7 RADIL TRAPPC12 HPS6 IL17RD PCNT

5.30e-1511052093435748872
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

TRPM4 SGSM1 HDAC4 MAP1B MYCBP2 INPP4A SLC22A23 OBSCN ACVR2B PLEKHM1 OSBPL5 SCP2 CACNA1H UTRN FBXW11 RASA2 WWP1 PSCA FBXL17 GRB10 CCDC57 PLBD2 SH2B1 WDR11 KNDC1 LRP1 OSTF1 CSMD1 EIF4G3 PCCA ZRANB1 PCNT KLHL26

9.80e-1114892093328611215
Pubmed

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases.

FBXO2 COPS7A FBXW5 BTRC FBXW11 FBXL17 FBXL20

9.51e-0862209729103612
Pubmed

Defining the membrane proteome of NK cells.

GBF1 ILK MYCBP2 RPS5 INTS1 ITGB7 XAB2 MDN1 TUBGCP3 OSBPL5 SCP2 CORO7 HEATR5B MED12 MED13 ABCC1 ARFGEF2 AP3B1 FADS1 WDR11 HPS6 EIF3D ADPGK PCNT

1.78e-0711682092419946888
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CTU2 GBF1 ILK MAP1B RPS5 INTS1 CARD10 MDN1 WDR48 DCAF13 KIF26B ARHGAP4 ZKSCAN1 TRAPPC12 PCK2 OTOG DNAH11

1.08e-066892091736543142
Pubmed

Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.

GBF1 PNPLA2 ARFGEF2

2.12e-065209321789191
Pubmed

Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.

BTRC FBXW11 WWP1 SYTL4

7.00e-0621209437005481
Pubmed

Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes.

PLAUR TEK LRP1

7.36e-06720938798151
Pubmed

Structural, expression, and evolutionary analysis of mouse CIAS1.

NLRP6 NLRP9 NLRP10

7.36e-067209315302403
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

AHCYL1 ILK MAP1B MYCBP2 RPS5 MDN1 PLAA TUBGCP3 CORO7 UTRN MED12 BTRC FNDC3B DCAF13 DDX49 RNF31 RASA2 WDR11 BAZ2A UTP4 EIF3D LTF PCK2

7.82e-0613532092329467282
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

MYCBP2 INPP4A RREB1 UTRN MED12 HOMEZ INPP5F RFX1 WDCP LRP1 PCCA PCNT

9.74e-064182091234709266
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

AHCYL1 MAP1B XAB2 TUBGCP3 PLCB3 WDR48 FNDC3B USP13 RNF31 NOA1 PARG PAPLN AP3B1 WDR11 WDCP

1.04e-056502091538777146
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

MAP1B MYCBP2 RPS5 INTS1 XAB2 MDN1 UTRN MED12 DCAF13 BAZ2A UTP4 EIF3D LTF EIF4G3 PCNT

1.10e-056532091522586326
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AHCYL1 MYCBP2 FRMD4B XAB2 STAT3 TTC7B LRRN2 PLAUR UTRN BTRC MED13 FBXW11 USP13 ADAMTS1 RBP4 ARFGEF2 SH2B1 WDR19 LRP1 EIF3D EIF4G3 PCNT

1.12e-0512852092235914814
Pubmed

New genetic associations detected in a host response study to hepatitis B vaccine.

GDF5 CARD10 GIMAP7 STAT3 RASSF5 FCGBP CD163L1 FBXW5 PLAUR C6 FNDC3B LRIT2 NLRP6 ARHGAP4 CD5L CD6 LTF

1.15e-058242091720237496
Pubmed

Array MAPPIT: high-throughput interactome analysis in mammalian cells.

FBXO2 FBXW5 BTRC FBXW11

1.71e-0526209419159283
Pubmed

Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome.

RABGGTA AP3B1 HPS6

1.75e-059209310193444
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

GBF1 ILK HDAC4 MAP1B KLHDC2 MYCBP2 STAT3 MDN1 UTRN KIF26B GRB10 INPP5F KLC4 HDAC7 RADIL EIF4G3 OTOG

2.01e-058612091736931259
Pubmed

Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.

FBXW5 BTRC FBXW11 FBXL17 FBXL20

2.04e-0555209537028429
Pubmed

Comparative interactome analysis of α-arrestin families in human and Drosophila.

MAP1B KDM5C UTRN PKN3 LRP12 RNF31 ADAMTS1 WWP1 INPP5F WDR11

2.20e-053132091038270169
Pubmed

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.

FBXO2 FBXW5 BTRC

2.49e-0510209331210753
Pubmed

Melanosome morphologies in murine models of hermansky-pudlak syndrome reflect blocks in organelle development.

RABGGTA AP3B1 HPS6

2.49e-0510209312445206
Pubmed

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage.

FBXW5 BTRC FBXW11

2.49e-0510209314603323
Pubmed

Fbxo45 inhibits calcium-sensitive proteolysis of N-cadherin and promotes neuronal differentiation.

MYCBP2 FBXW5 BTRC

3.41e-0511209325143387
Pubmed

Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.

STRC STRCP1 OTOG

3.41e-0511209331776257
Pubmed

PSM/SH2B1 splice variants: critical role in src catalytic activation and the resulting STAT3s-mediated mitogenic response.

STAT3 SH2B1

3.59e-052209218247337
Pubmed

The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells.

CD5 CD6

3.59e-052209212473675
Pubmed

FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts with the C-Terminal Region of STAT3 and Represses Malignant Transformation of Melanoma Cells.

STAT3 FNDC3B

3.59e-052209226948083
Pubmed

Hdac7 promotes lung tumorigenesis by inhibiting Stat3 activation.

STAT3 HDAC7

3.59e-052209229126425
Pubmed

Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.

KDM5C KDM5D

3.59e-052209210441747
Pubmed

Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.

RASSF5 BTRC

3.59e-052209225217643
Pubmed

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

LRP1 LTF

3.59e-05220921464627
Pubmed

Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.

KDM5C KDM5D

3.59e-052209216416087
Pubmed

Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.

KDM5C KDM5D

3.59e-052209232081420
Pubmed

The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis.

CD5 CD6

3.59e-052209230500820
Pubmed

KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1.

KDM5C ABCC1

3.59e-052209230257334
Pubmed

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

STRC STRCP1

3.59e-052209234910522
Pubmed

New STAT3-FOXL2 pathway and its function in cancer cells.

STAT3 FOXL2NB

3.59e-052209231221094
Pubmed

Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation.

HDAC4 HDAC7

3.59e-052209238657041
Pubmed

A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.

KDM5C KDM5D

3.59e-05220927524912
Pubmed

LRP1 regulates remodeling of the extracellular matrix by fibroblasts.

PLAUR LRP1

3.59e-052209219699300
Pubmed

The characteristics and roles of β-TrCP1/2 in carcinogenesis.

BTRC FBXW11

3.59e-052209233021036
Pubmed

Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.

SPEG OBSCN

3.59e-052209215185077
Pubmed

Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity.

PLAUR LRP1

3.59e-052209211359936
Pubmed

Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

PLAUR LRP1

3.59e-052209219008962
Pubmed

Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease.

CD5 CD6

3.59e-052209236211446
Pubmed

Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.

STRC STRCP1

3.59e-052209211687802
Pubmed

Clearance of Neutrophils From ICH-Affected Brain by Macrophages Is Beneficial and Is Assisted by Lactoferrin and CD91.

LRP1 LTF

3.59e-052209238063014
Pubmed

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.

STAT3 RFX1

3.59e-052209229422534
Pubmed

Expression of LRP Gene in Breast Cancer Patients Correlated with MRP1 as Two Independent Predictive Biomarkers in Breast Cancer.

ABCC1 LRP1

3.59e-052209230486550
Pubmed

Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.

STAT3 INPP5F

3.59e-052209225476455
Pubmed

Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6.

CD5 CD6

3.59e-052209234070159
Pubmed

Specificity, location and function of βTrCP isoforms and their splice variants.

BTRC FBXW11

3.59e-052209221138764
Pubmed

Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity.

STAT3 FNDC3B

3.59e-052209225671570
Pubmed

Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.

KDM5C KDM5D

3.59e-05220929060413
Pubmed

Differential dysregulation of β-TrCP1 and -2 by HIV-1 Vpu leads to inhibition of canonical and non-canonical NF-κB pathways in infected cells.

BTRC FBXW11

3.59e-052209237341489
Pubmed

Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation.

MED12 PRC1

3.59e-052209227096886
Pubmed

Molecular linkage of the mouse CD5 and CD6 genes.

CD5 CD6

3.59e-05220928781125
Pubmed

CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.

GBF1 INTS1 MDN1 TUBGCP3 ABCC1 ARFGEF2

4.08e-05104209631240132
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

AHCYL1 MAP1B MYCBP2 COPS7A TUBGCP3 FBXW5 DMWD UTRN BTRC FBXW11 WDR48 USP13 ADAMTS1 SYTL4 LRP1 EIF3D EIF4G3 ZRANB1

4.09e-0510052091819615732
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

SPEG INTS1 HEATR5B HOMEZ ADAMTS1 SH2B1 WDR11

4.13e-05153209710718198
Pubmed

Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

FBXW5 BTRC FBXW11

4.52e-0512209318354482
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ILK MYCBP2 OBSCN ACTN2 TUBGCP3 UTRN TRIM38 MED13 FNDC3B WWP1 XIRP2 ADPGK

5.28e-054972091223414517
Pubmed

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.

KDM5C BTRC FBXW11

5.85e-0513209329507620
Pubmed

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.

FBXW5 BTRC FBXW11

5.85e-0513209333962073
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRRC24 SPEG OBSCN LRRN2 LRIT2 MXRA8 TEK

5.94e-05162209725826454
Pubmed

Identification of a family of human F-box proteins.

FBXO2 FBXW5 BTRC FBXW11

7.16e-0537209410531035
Pubmed

The genetics of NOD-like receptors in Crohn's disease.

NLRP6 NLRP9 NLRP10

7.42e-0514209320403135
Pubmed

NALPs: a novel protein family involved in inflammation.

NLRP6 NLRP9 NLRP10

7.42e-0514209312563287
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

GBF1 MYCBP2 KDM5C RREB1 MDN1 PLCB3 DMWD MED13 IQCK HOMEZ PARG ARFGEF2 RFX1 HDAC7 BAZ2A

7.67e-057742091515302935
Pubmed

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.

TRPM4 AHCYL1 GBF1 KLHDC2 INTS1 FANCG MDN1 LRRN2 LRP12 PNPLA2 WWP1 ARFGEF2 ATP8B2 TMTC4 HPS6 STX10 PCCA ADPGK

8.16e-0510612091833845483
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

GBF1 MAP1B FBXW5 BTRC FBXW11 ZKSCAN1 WDR11 EIF3D

8.68e-05232209825515538
Pubmed

Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.

KLHDC2 CARD10 BTRC FBXW11 FBXL17 KLHL26

9.06e-05120209627565346
Pubmed

Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis.

ACVR2B DNAH11

1.07e-043209212112458
Pubmed

The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.

BTRC FBXW11

1.07e-043209231406304
Pubmed

Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.

STRC STRCP1

1.07e-043209230801007
Pubmed

Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.

PEX5 SCP2

1.07e-043209219584060
Pubmed

Stability of Wake-Sleep Cycles Requires Robust Degradation of the PERIOD Protein.

BTRC FBXW11

1.07e-043209229103939
Pubmed

Identification of a signal-responsive nuclear export sequence in class II histone deacetylases.

HDAC4 HDAC7

1.07e-043209211509672
Pubmed

Integrin-Linked Kinase, Snail and Multidrug Resistance Protein 1: Three concordant players in the progression of non-small cell lung cancer.

ILK ABCC1

1.07e-043209225964055
Pubmed

Role of lactoferrin and its receptors on biliary epithelium.

LRP1 LTF

1.07e-043209229550924
Pubmed

SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation.

BTRC FBXW11

1.07e-043209218354483
Pubmed

Proteasomal degradation of eukaryotic elongation factor-2 kinase (EF2K) is regulated by cAMP-PKA signaling and the SCFβTRCP ubiquitin E3 ligase.

BTRC FBXW11

1.07e-043209223640883
Pubmed

Utrophin binds laterally along actin filaments and can couple costameric actin with sarcolemma when overexpressed in dystrophin-deficient muscle.

ACTN2 UTRN

1.07e-043209212006649
Pubmed

CD6 modulates thymocyte selection and peripheral T cell homeostasis.

CD5 CD6

1.07e-043209227377588
Pubmed

Reversal of multidrug resistance by icaritin in doxorubicin-resistant human osteosarcoma cells.

STAT3 ABCC1

1.07e-043209229425587
Pubmed

The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2.

BTRC FBXW11

1.07e-043209218782782
Pubmed

Multidrug resistance proteins in renal cell carcinoma.

ABCC1 LRP1

1.07e-043209219393132
Pubmed

Tip60 is a co-repressor for STAT3.

STAT3 HDAC7

1.07e-043209212551922
Pubmed

Mediator kinase module and human tumorigenesis.

MED12 MED13

1.07e-043209226182352
Pubmed

Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.

GBF1 PNPLA2

1.07e-043209231610914
Pubmed

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

GBF1 ARFGEF2

1.07e-043209223386609
Pubmed

SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation.

STAT3 SH2B1

1.07e-043209224396070
Pubmed

Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation.

BTRC FBXW11

1.07e-043209217121803
Pubmed

Development and characterization of multidrug resistant human hepatocarcinoma cell line in nude mice.

ABCC1 LRP1

1.07e-043209217075973
Pubmed

Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase.

BTRC FBXW11

1.07e-043209228483528
Pubmed

Critical role for IL-1β in DNA damage-induced mucositis.

BTRC FBXW11

1.07e-043209224469832
Pubmed

Regulation of hepatic six transmembrane epithelial antigen of prostate 4 (STEAP4) expression by STAT3 and CCAAT/enhancer-binding protein alpha.

STAT3 STEAP4

1.07e-043209220304921
Pubmed

The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.

PEX5 SCP2

1.07e-043209221375735
Pubmed

Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution.

CD5 CD6

1.07e-043209235767366
InteractionTOP3B interactions

TRPM4 GBF1 HDAC4 LRRC24 PCNX3 MYCBP2 SPEG INTS1 OBSCN CARD10 SFI1 PLEKHM1 MDN1 EXOSC6 OSBPL5 ARC CACNA1H DMWD MED12 MED13 PKN3 SEMA6C PLXNA3 PNPLA2 TMEM158 WWP1 ARFGEF2 GRB10 PAPLN HDAC7 RADIL TRAPPC12 HPS6 IL17RD PCNT

1.26e-06147020135int:TOP3B
GeneFamilyWD repeat domain containing

PLAA FBXW5 TAF5 CORO7 DMWD BTRC FBXW11 WDR48 DCAF13 WDR19 WDR11 UTP4 WDR86

3.13e-0726215113362
GeneFamilyWD repeat domain containing|F-box and WD repeat domain containing

FBXW5 BTRC FBXW11

8.97e-05111513559
GeneFamilyHistone deacetylases, class IIA

HDAC4 HDAC7

4.11e-0441512992
GeneFamilyNLR family

NLRP6 NLRP9 NLRP10

1.15e-03251513666
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP6 NLRP9 NLRP10

1.15e-03251513994
CoexpressionGSE37532_WT_VS_PPARG_KO_VISCERAL_ADIPOSE_TISSUE_TCONV_UP

PCNX3 MYCBP2 XAB2 DQX1 TUBGCP3 RHBDL1 RFX1 TRAPPC12 LRP1 OSTF1 FBXL20

6.02e-0719920811M8964
CoexpressionGSE11386_NAIVE_VS_MEMORY_BCELL_DN

MYCBP2 MDN1 UTRN FBXL17 PELI1 GPR183 CD5 CD6 EIF4G3

5.07e-061582089M372
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

GBF1 HDAC4 MAP1B MYCBP2 RGL1 MDN1 TUBGCP3 PLAUR BTRC MED13 FBXW11 ABCC1 USP13 WWP1 PARG INPP5F AP3B1 TFPI EIF4G3 PCCA PCNT

5.09e-0685620821M4500
CoexpressionNIKOLSKY_MUTATED_AND_AMPLIFIED_IN_BREAST_CANCER

ARC CACNA1H DCAF13 ARFGEF2 RADIL MSLNL PCNT

1.02e-05942087M18108
CoexpressionGSE5960_TH1_VS_ANERGIC_TH1_DN

HGFAC AHCYL1 TTC7B SCP2 FBXW11 ABCC1 PNPLA2 AP3B1 CD6

3.34e-052002089M5638
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000

HDAC4 MAP1B MYCBP2 SPEG RGL1 CPLANE1 MED13 TMEM158 ARFGEF2 PELI1 ZKSCAN1 TMTC4 WDCP

9.78e-0631220213gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ Genital tubercle_emap-6706_k-means-cluster#1_top-relative-expression-ranked_1000

AHCYL1 MAP1B KLHDC2 ACVR2B CPLANE1 UTRN MED13 ARFGEF2 PELI1 WDCP

3.32e-0520920210gudmap_developingLowerUrinaryTract_e14.5_ Genital tubercle_1000_k1
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000

KLHDC2 MYCBP2 ACVR2B CPLANE1 UTRN MED13 ARFGEF2 GRB10 PELI1 ZKSCAN1 WDCP

4.31e-0526120211gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#1_top-relative-expression-ranked_500

AHCYL1 MAP1B CPLANE1 MED13 FBXW11 TMEM158 PELI1 AP3B1 PREX2 WDCP

7.70e-0523120210gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k1
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500

MAP1B ACVR2B CPLANE1 MED13 TMEM158 ARFGEF2 ZKSCAN1 WDCP

9.25e-051492028gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
ToppCellsevere_influenza-Platelet|World / disease group, cell group and cell class (v2)

ILK MAP1B TTC7B ALOX12 LRP12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

2.19e-0818820910b54632baa682aaf51100d44e7f114a54d5edd695
ToppCell10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

SPEG SFI1 ACTN2 KDM5D STAT3 UTRN ATP8B2 FBXL20 GOLGA8A

7.75e-081622099b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCellInfluenza-Influenza_Severe-Others-Platelet|Influenza_Severe / Disease, condition lineage and cell class

ILK TTC7B ALOX12 LRP12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

4.63e-072002099548e8e2f0e4225827db58b0c8b05221f18ae482b
ToppCellControl-Control-Lymphocyte-T/NK-CD8+_T_naive|Control / Disease, condition lineage and cell class

RPS5 OBSCN GIMAP7 FCGBP MXRA8 ATP8B2 CD5 CD6 GOLGA8A

4.63e-072002099906de95adc9716982ab32f216dddeb52639bad06
ToppCellLPS-IL1RA+antiTNF-Stromal_mesenchymal-Fibroblasts|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPEG NXPE2 OSBPL5 ADAMTS1 SLC5A2 MISP RADIL WDCP

8.01e-071572098f086753b51860e23f1275bd75e8802d2a7d7b70a
ToppCell3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC22A23 CARD10 GIMAP7 UTRN PLBD2 TFPI TMTC4 TMEM140

1.81e-06175209843be63976da5ad0764d24d90919a77ce46068f52
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 GIMAP7 ITGB7 RASSF5 CD163L1 GPR183 CD5 CD6

1.81e-06175209824f07bc6583129835bc67c04dabf5e82f6b8c369
ToppCellfacs-Heart-LA-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 CD163L1 ZKSCAN2 GPR183 ARHGAP4 CD5 CD6

2.06e-061782098d32b4e9c3d1f246ad49e2d8f6497989af68a6c00
ToppCellfacs-Heart-LA-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 CD163L1 ZKSCAN2 GPR183 ARHGAP4 CD5 CD6

2.06e-061782098b7abf5656233e1a9cdbbe978dfa84d16f14b0be0
ToppCellInfluenza_Severe-Platelet|Influenza_Severe / Disease group and Cell class

TTC7B ALOX12 LRP12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

2.33e-0618120984d037b098bb6f780ed8b15c0ec23a6f4d86bf45a
ToppCellInfluenza_Severe-Platelet|World / Disease group and Cell class

TTC7B ALOX12 LRP12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

2.33e-0618120985cdf935a89440114a58fa2042c1daed740d91c00
ToppCellsevere_influenza-Platelet|severe_influenza / disease group, cell group and cell class (v2)

MAP1B TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

2.43e-0618220982018b71ec26bf3cd7ecdc04d5473900a697cd58a
ToppCellCOVID-19-kidney-Mito-rich_EC|kidney / Disease (COVID-19 only), tissue and cell type

CMPK2 GIMAP7 UTRN PKN3 GRB10 TEK PREX2 PAX4

2.53e-0618320983c4153479fc4ab2d073d92cee120480015555914
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

MYCBP2 ABCA8 STAT3 RGL1 UTRN LRP12 TEK PREX2

2.63e-06184209867164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGFAC SGSM1 NXPE2 RREB1 FBXO2 DQX1 NLRP6 MISP

2.85e-061862098ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 UTRN PELI1 GPR183 CD5 CD6

2.85e-061862098e23e1246914e230369a716d0d666b98383bf8512
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 UTRN PELI1 GPR183 CD5 CD6

2.85e-0618620984dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCellfacs-Heart-LA-24m-Myeloid-macrophage|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGFAC SGSM1 NXPE2 RREB1 FBXO2 DQX1 NLRP6 MISP

2.85e-061862098246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

ARC PKN3 ADAMTS1 TEK PREX2 TFPI CSMD1 GPRC5B

3.21e-061892098fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

3.34e-061902098a1f8757dc719ed030f67d65735358a8d7a407bad
ToppCellPBMC-Mild-Hematopoietic-Platelet|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

3.34e-061902098726aeb280ea911f3551b18e388c4f7580ae2ea74
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

3.34e-06190209850ea3ff7ba1ca335b4e4538fae5f9b74b1fc10f7
ToppCellPBMC-Mild-Hematopoietic-Platelet|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

3.34e-061902098c4f55f5a0c42aeb571791925ea80e02fac320608
ToppCellmild_COVID-19-Platelet|mild_COVID-19 / disease group, cell group and cell class (v2)

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

3.47e-061912098968e2d48969884dd21b8a87f199af94a7410b0dd
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Lymphocytic-T_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS5 ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

3.61e-061922098ccefe04e181e6b8dcabdd25642fb1fb4b9481782
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS5 OBSCN GIMAP7 FCGBP MXRA8 ATP8B2 CD6 GOLGA8A

3.75e-061932098d371403b51281a6e37652fa8dc1b2dd81d2ab371
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RPS5 OBSCN GIMAP7 FCGBP MXRA8 ATP8B2 CD6 GOLGA8A

3.75e-0619320983cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RPS5 OBSCN GIMAP7 FCGBP MXRA8 ATP8B2 CD6 GOLGA8A

3.75e-0619320986436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCellPBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

RPS5 OBSCN GIMAP7 FCGBP MXRA8 ATP8B2 CD6 GOLGA8A

3.75e-061932098d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCellhealthy_donor-Lymphocytic-T_cell-CD4+_Memory_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

RPS5 GIMAP7 WWP1 GPR183 ATP8B2 CD5 CD6 GOLGA8A

4.36e-061972098c842d169dfce9af3ed7c01dc7e940c0bdd21388c
ToppCell10x5'-Liver-Lymphocytic_T_CD4|Liver / Manually curated celltypes from each tissue

FRMD4B ABCC1 PELI1 GPR183 ATP8B2 CD5 CD6 GOLGA8A

4.36e-0619720984891111894b741555f549deec6af8006376d9358
ToppCellCOVID_vent-Lymphocytic-T_cell-CD4+_Memory_T_cell|COVID_vent / Disease condition, Lineage, Cell class and subclass

RPS5 GIMAP7 WWP1 GPR183 ATP8B2 CD5 CD6 GOLGA8A

4.53e-06198209858f208b76cb0adcecdf632d92f92833a06f9bf71
ToppCellParenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SPEG HDX NOTCH2NLB BTRC LRP12 WDR19 UTP4 RASL10B

4.53e-061982098cc2b5b632e73e44bb60050f0db10d8f0dbb859fa
ToppCellLPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ACTN2 ABCA8 ADAMTS1 KIF26B MXRA8 PREX2 SYTL4 LRP1

4.87e-0620020989b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated|COVID-19_Mild / Disease, condition lineage and cell class

OBSCN CMPK2 GIMAP7 MDN1 ATP8B2 CD5 CD6 GOLGA8A

4.87e-062002098d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

MYCBP2 ACTN2 ABCA8 ADAMTS1 MXRA8 SYTL4 LRP1 WDR86

4.87e-062002098a7ef7022b8efcaedb7319b0b43d8c4e99d788fe2
ToppCellCOVID-19-COVID-19_Mild-Others|COVID-19_Mild / Disease, condition lineage and cell class

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

4.87e-062002098ecf94be4bb961ec343471547f2ea327bc6f709f4
ToppCellCOVID-19-COVID-19_Mild-Others-Platelet|COVID-19_Mild / Disease, condition lineage and cell class

ILK TTC7B ALOX12 TMEM158 TFPI XIRP2 SYTL4 TMEM140

4.87e-062002098bf5e7a36d6ed44a30f906702b40ace3ecd423398
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

SLC22A23 FRMD4B RGL1 CD163L1 CD5L SYTL4 KNDC1

9.15e-0615620979a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellPND07-28-samps-Lymphocyte|PND07-28-samps / Age Group, Lineage, Cell class and subclass

GIMAP7 KDM5D ITGB7 CD163L1 ARC CD5 CD6

9.54e-061572097105f2711d7bae3be36714954e103c61cf021f957
ToppCellImmune_cells-T_cells|World / Lineage and Cell class

ACTN2 GIMAP7 ITGB7 PELI1 GPR183 CD5 CD6

1.22e-051632097c5afdb5e7700bbd3ee8276910f9c4b4b3bcc3266
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 ITGB7 CHRND CD163L1 LRRN2 GPR183 MSLNL

1.27e-051642097467ad12884b70d243988174ae960ee2b7b6cfb0c
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Ly6g5b+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 ITGB7 CHRND CD163L1 LRRN2 GPR183 MSLNL

1.27e-0516420974e1861382c9e93856da19303474c8975c19706d2
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC22A23 LRRC14B HOMEZ RHBDL1 CCDC57 OTOG

1.34e-051102096c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 ITGB7 CHRND CD163L1 LRRN2 GPR183 MSLNL

1.43e-0516720975d1919bea8e5a52ac6fc953caff15509b7142923
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 GIMAP7 ITGB7 RASSF5 UTRN GPR183 CD5

1.43e-051672097d72b08b3cbc34b30a11dcf512e472b64d1606ec1
ToppCellfacs-Lung-24m-Hematologic-lymphocytic-immature_innate_lymphoid_cell-Ly6g5b+_T|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 ITGB7 CHRND CD163L1 LRRN2 GPR183 MSLNL

1.43e-051672097d8f497860d48342a3aaaad328f88e4d55ab4faeb
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 GIMAP7 ITGB7 RASSF5 UTRN GPR183 CD5

1.43e-05167209722f7384ff2044898d7b0b01cb9d9a3cbaa93a9a3
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

1.60e-0517020977040f7b1e4d8d26db787449e557371c5d872c95a
ToppCelldroplet-Liver-Npc|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS5 ACTN2 GIMAP7 CRLF2 ITGB7 C6 CD5L

1.60e-05170209709c836840216905d545a25a4fc1bbd0699576c77
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

1.93e-051752097b66731573e79576fbf17538059cb8243dd4903c4
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-24m-Lymphocytic-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

1.93e-0517520975f18077e5c3edc6a2708315db53683afa4a6d4a8
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D175|Adult / Lineage, Cell type, age group and donor

ARC ADAMTS1 TEK PREX2 HHIPL1 CSMD1 GPRC5B

1.93e-0517520970a65ddfa8c2e8efb5b5338cf07661cb78157a23c
ToppCellfacs-Trachea-nan-18m-Lymphocytic|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.00e-0517620979dd862dcee6947a53189728f6b4cd40e7b67cb71
ToppCelldroplet-Bladder-nan-24m-Hematologic-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.00e-0517620970089b50d607f4d2f18639fab0f3fc779227baa7a
ToppCellfacs-Trachea-nan-18m-Lymphocytic-T_cell|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.00e-051762097d990e7af8120210100d13caa0465b27cf77a451a
ToppCellfacs-Trachea-nan-18m-Lymphocytic-nan|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.00e-05176209714c6c3fdb53f9dfc02b951bc955b90213110c089
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 RASSF5 GPR183 ARHGAP4 CD5 CD6

2.00e-05176209727c5ddd67de52101360ef7de8fcfa041066d97db
ToppCellfacs-Heart-RA-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 RASSF5 CD163L1 GPR183 CD5 CD6

2.07e-05177209731201a72b7c1bdb0eff892b7072a35c80fd34727
ToppCellfacs-Heart-RA-18m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 RASSF5 CD163L1 GPR183 CD5 CD6

2.07e-05177209789d0131320cd96af8b0ee54f0f4d4771d17ef44e
ToppCelldroplet-Bladder-nan-3m-Epithelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM4 DQX1 GPR183 VARS2 RADIL KIAA0825

2.10e-051192096018162114bc22a9780fded5887f1f78211851700
ToppCellfacs-Heart-LA-18m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GIMAP7 ITGB7 CD163L1 GPR183 ARHGAP4 CD5 CD6

2.15e-051782097b4b4e021e86d1d523fa40695cb0a91021dee27d1
ToppCelldroplet-Mammary_Gland-nan-18m-Lymphocytic-T_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS5 GIMAP7 ITGB7 CD163L1 CD5 CD6 OSTF1

2.23e-05179209748ee1c6d6402c7f5d6578f8de14da6f55aa952d6
ToppCellControl-Endothelial-Endothelial-Activated_Gen_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HDX CMPK2 CARD10 TEK NLRP9 LTF

2.31e-051212096a5962d1c476e6966870832b72d511607e047248b
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FRMD4B ALOX12 LRP12 TFPI XIRP2 SYTL4 TMEM140

2.31e-0518020971be264962fd4ed0bb59f9b8a6956c4239ca32e05
ToppCellfacs-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 GIMAP7 ITGB7 GPR183 CD5 CD6 XKRX

2.31e-051802097d6e69ac2bd619557ef62ada684c37a44dc4e3f41
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.31e-051802097c35cf2510183c09688453b12e721d264cf57caad
ToppCelldroplet-Mammary_Gland-nan-18m-Lymphocytic-T_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPS5 GIMAP7 ITGB7 CD163L1 CD5 CD6 OSTF1

2.31e-0518020977bdc040461f350dd3136219341b39679fbca317e
ToppCellPBMC-Mild-Hematopoietic-Platelet-Platelet-plt_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FRMD4B ALOX12 LRP12 TFPI XIRP2 SYTL4 TMEM140

2.31e-0518020975568063c2518fadb638e665635061ec10d00fb6a
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-CD45____T_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.39e-051812097e8a68214930a6d15c47207656601b2209e283aae
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-T_cell-T_cell_of_trachea|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.39e-051812097a23b2e12bc133166e3ed45ab7116f74afbca6eec
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

INPP4A GIMAP7 KDM5D UTRN CD5 CD6 GOLGA8A

2.39e-051812097986c036e656f24fe374807e2711cec9e3c83c892
ToppCellfacs-Trachea-18m-Hematologic-lymphocytic-T_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.39e-0518120977875fe64ec500a925245ab50cffd6890eabaea8c
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-DN3_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM185A NXPE2 KDM5D ACVR2B FRMD4B OSBPL5 PEX5

2.39e-051812097e2d03115a87f45a7ddd3ade6b9ac3843639bd41a
ToppCelldroplet-Liver-nan-3m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR182 MXRA8 ZKSCAN2 TEK HDAC7 PREX2 TFPI

2.39e-051812097fcc94f04dae98b817ec06b282d2e887804d37ae5
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM185A NXPE2 KDM5D ACVR2B FRMD4B OSBPL5 PEX5

2.39e-051812097d8d11ef83c4b8b6a6f5c8728e03059e45a8ad264
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B ABCA8 MXRA8 STEAP4 LRP1 WDR86 HHIPL1

2.39e-051812097c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MAP1B ABCA8 MXRA8 STEAP4 LRP1 WDR86 HHIPL1

2.39e-051812097c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Cbln1_(Layer_5a,_entorhinal_cortex_,_Cbln1+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

LRIT2 GPR6 PSCA MSLNL XKRX

2.56e-057420950be24b07a2503a16ece1489e765200be4c7253cc
ToppCellfacs-GAT-Fat-24m-Lymphocytic|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.57e-051832097377c2c6fcb2fd41396dd7a7a90e9d7ccafccf2f0
ToppCelldroplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR182 MXRA8 ZKSCAN2 TEK HDAC7 PREX2 TFPI

2.57e-051832097709a486154b3157427deb3b8886b63ac39ea42dd
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC22A23 GPR182 GIMAP7 PNPLA2 TFPI RADIL TMEM140

2.57e-051832097a90ffd9c50caa65f537a2e441e37655e1b622327
ToppCell3'-GW_trimst-1.5-SmallIntestine-Endothelial-lymphatic_endothelial|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC22A23 GPR182 GIMAP7 PNPLA2 TFPI RADIL TMEM140

2.57e-05183209713ad20ec140ef5b96fdace3369b5befc0f40bb76
ToppCelldroplet-Liver-nan-3m-Endothelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPR182 MXRA8 ZKSCAN2 TEK HDAC7 PREX2 TFPI

2.57e-051832097dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCellfacs-GAT-Fat-24m-Lymphocytic-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.57e-051832097f0a6f4f8563491c83fb991b9fb81e75fec7d1ace
ToppCellfacs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INPP4A ACTN2 GIMAP7 ITGB7 RASSF5 CD5 CD6

2.57e-05183209786c67f258fa25a818797df5d4df7f27b44cb5381
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN SFI1 KIF26B XIRP2 CSMD1 OTOG DNAH11

2.66e-0518420972cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN SFI1 KIF26B XIRP2 CSMD1 OTOG DNAH11

2.66e-0518420972b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-SELL+_CD8_T|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GIMAP7 RASSF5 CCDC57 ARHGAP4 CD5 CD6 PCNT

2.66e-051842097c80acd6a81a3633d72813a77223879d0be254f93
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OBSCN SFI1 KIF26B XIRP2 CSMD1 OTOG DNAH11

2.66e-051842097ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCelldroplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FAM185A TTC7B DMWD ALOX12 TMEM158 HDAC7 ATP8B2

2.75e-05185209760206c7322b4ddb2010040aac70561df842c9843
ToppCellPBMC-Severe-Hematopoietic-Platelet-Platelet-plt_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FRMD4B ALOX12 LRP12 TFPI XIRP2 SYTL4 TMEM140

2.75e-051852097698ff44fd2d9b3ad5cea45f4cff9bfc64c559b62
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

PKN3 ADAMTS1 TEK PREX2 TFPI CSMD1 GPRC5B

2.75e-051852097a7ae76058b2082020cadec49d63b9f4e24d21734
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 LRRC14B CACNA1H USP13 NLRP10 XIRP2 RASL10B

2.85e-051862097337f768cc43db2db96ba6495b076006b1a5b0331
ToppCellfacs-Heart-LA-24m-Mesenchymal-ventricular_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 LRRC14B CACNA1H USP13 NLRP10 XIRP2 RASL10B

2.85e-051862097e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCelldroplet-Limb_Muscle-nan-24m-Lymphocytic-T_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 GIMAP7 ITGB7 CD163L1 GPR183 CD5 CD6

2.85e-051862097c5a27a128677aa04154eb78402d01fed149875de
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 CD163L1 LRRN2 GPR183 PRC1 CD5 CD6

2.85e-05186209761de94c9ba90e7b6780694199c059c798b1488ae
ToppCelldroplet-Lung-nan-21m-Lymphocytic-T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACTN2 ITGB7 CD163L1 LRRN2 STRC GPR183 CD5

2.85e-0518620978fc0487fc1b2fd403bd7c257fcabbff652f971c9
ToppCellAdult-Endothelial-endothelial_cell_of_artery|Adult / Lineage, Cell type, age group and donor

ARC PKN3 ADAMTS1 TEK PREX2 CSMD1 GPRC5B

2.85e-0518620972d1c4ea2e401db89971582ee54618a8b0c81b8ac
ToppCellPBMC-Severe-Hematopoietic-Platelet-Platelet-plt_4|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FRMD4B ALOX12 LRP12 TFPI XIRP2 SYTL4 TMEM140

2.85e-051862097981116561986f94e9cc3ee64fb37dab9a31d427a
DiseaseMalignant neoplasm of breast

CTU2 HDAC4 OBSCN STAT3 CHRND RGL1 SCP2 MED12 FNDC3B ABCC1 ADAMTS1 NOA1 ARFGEF2 PRC1 TEK HDAC7 NLRP9 TMTC4 TRAPPC12 WDCP RASL10B

1.68e-05107420221C0006142
Diseaseautosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)

STRC STRCP1

4.66e-0522022DOID:0110471 (implicated_via_orthology)
Diseaseobesity (implicated_via_orthology)

CAPN9 STAT3 SCP2 PLCB3 CORO7 MED12 MED13 PNPLA2

1.25e-042152028DOID:9970 (implicated_via_orthology)
Diseasedisease of cellular proliferation (is_marker_for)

PLAUR TFPI

1.39e-0432022DOID:14566 (is_marker_for)
Diseasesyndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)

KDM5C KDM5D

2.77e-0442022DOID:0060809 (implicated_via_orthology)
DiseaseMenkes disease (implicated_via_orthology)

BTRC FBXW11

4.60e-0452022DOID:1838 (implicated_via_orthology)
Diseaseresting heart rate

SPEG FRMD4B RASSF5 FBXL17 FADS1 CSMD1

5.83e-041492026EFO_0004351
Diseasealpha-linolenic acid measurement

FADS1 KIAA0825 CSMD1

6.51e-04252023EFO_0007759
Diseasepre-eclampsia (is_marker_for)

ACVR2B PLAUR RBP4 TFPI

6.77e-04582024DOID:10591 (is_marker_for)
Diseaseprocollagen C-endopeptidase enhancer 1 measurement

FADS1 DNAH11

6.87e-0462022EFO_0801920
Diseaseperiventricular nodular heterotopia (is_implicated_in)

MAP1B ARFGEF2

6.87e-0462022DOID:0050454 (is_implicated_in)
Diseaseblood manganese measurement

INPP5F CSMD1 KLHL26

8.19e-04272023EFO_0007581
Diseaselevel of Sterol ester (27:1/22:6) in blood serum

FNDC3B FADS1

9.57e-0472022OBA_2045201
DiseaseAbnormality of the eye

MED13 FBXW11

9.57e-0472022C4316870
DiseaseHermansky-Pudlak syndrome (is_implicated_in)

AP3B1 HPS6

9.57e-0472022DOID:3753 (is_implicated_in)
Diseasealcohol dependence measurement, electroencephalogram measurement

FRMD4B ADAMTS1

9.57e-0472022EFO_0004357, EFO_0007835
DiseasePeriventricular Nodular Heterotopia

MAP1B ARFGEF2

9.57e-0472022C1868720
Diseasediabetes mellitus

FAM185A MYCBP2 RREB1 PAX4

1.23e-03682024EFO_0000400
Diseasepepsinogen I/II ratio

ARC PSCA

1.27e-0382022EFO_0010149
Diseasemyocardial infarction (is_marker_for)

PLAUR RBP4 TFPI

1.48e-03332023DOID:5844 (is_marker_for)
DiseaseSpastic Paraplegia

WDR48 KLC4

1.63e-0392022C0037772
Diseaseretinal degeneration (is_implicated_in)

HDAC4 PRPH2

1.63e-0392022DOID:8466 (is_implicated_in)
Diseasemean corpuscular hemoglobin concentration

RREB1 FRMD4B STAT3 FANCG PLCB3 MED13 FNDC3B ABCC1 ARFGEF2 FBXL17 HDAC7 SH2B1 NLRP6 FADS1 P2RY2 EIF4G3 FBXL20

1.64e-03110520217EFO_0004528
Diseaseelectroencephalogram measurement

SGSM1 FRMD4B FNDC3B OSTF1

1.69e-03742024EFO_0004357
Diseaseduodenal ulcer

PSCA TTLL8 PAX4

1.91e-03362023EFO_0004607
DiseaseHermanski-Pudlak Syndrome

AP3B1 HPS6

2.02e-03102022C0079504
DiseaseHermansky-Pudlak syndrome

AP3B1 HPS6

2.02e-03102022cv:C0079504
Diseasemacrophage colony stimulating factor measurement

AHCYL1 PREX2 CSMD1

2.07e-03372023EFO_0008217
Diseasemetabolite measurement, body weight gain

PEX5 FADS1

2.94e-03122022EFO_0004566, EFO_0004725
DiseasePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma

CRLF2 STAT3

2.94e-03122022C0023485
Diseasephotoreceptor cell layer thickness measurement

GBF1 MAP1B RREB1 ST7L PRPH2

3.59e-031482025EFO_0803370
Diseaseinflammatory bowel disease

HGFAC SLC22A23 STAT3 LRP12 PRXL2B GPR183 HDAC7 SH2B1 CD6

3.96e-034492029EFO_0003767
Diseasealbuminuria

NXPE2 PAPLN CSMD1 FBXL20

4.02e-03942024EFO_0004285
Diseasemean platelet volume

PCNX3 SLC22A23 ST7L RASSF5 FANCG ALOX12 HOMEZ PRC1 HDAC7 NLRP6 FADS1 P2RY2 SYTL4 BAZ2A FBXL20

4.63e-03102020215EFO_0004584
DiseaseFEV/FEC ratio

HDAC4 SPEG RREB1 SPTBN5 RASSF5 FCGBP TTC7B LRRN2 FNDC3B ADAMTS1 FBXL17 ZKSCAN2 ZKSCAN1 SYTL4 LRP1 HHIPL1 CSMD1

4.81e-03122820217EFO_0004713
Diseasemyocardial infarction (biomarker_via_orthology)

PLAUR PLCB3 ADAMTS1 TEK TFPI

4.99e-031602025DOID:5844 (biomarker_via_orthology)
Diseasebody mass index, fasting blood glucose measurement

RREB1 GRB10 FADS1

5.17e-03512023EFO_0004340, EFO_0004465
Diseasesyndromic intellectual disability (implicated_via_orthology)

KDM5C KDM5D

5.25e-03162022DOID:0050888 (implicated_via_orthology)
Diseasepulmonary fibrosis (is_implicated_in)

AP3B1 TFPI

5.25e-03162022DOID:3770 (is_implicated_in)
Diseasecortical surface area measurement

GDF5 PCNX3 MYCBP2 RREB1 ST7L FRMD4B PLEKHM1 COPS7A FOXL2NB TAF5 KIF26B FBXL17 TFPI KIAA0825 RASL11B IL17RD PCCA DNAH11

5.29e-03134520218EFO_0010736
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

HGFAC AHCYL1 ABCA8 PLCB3 RABGGTA RASA2 FADS1

5.89e-033122027EFO_0004612, EFO_0010351
Diseaseimmature granulocyte count

PLAUR PKN3

5.93e-03172022EFO_0803542
Diseasephosphatidylcholine 40:6 measurement

TMTC4 CSMD1

5.93e-03172022EFO_0010389
DiseasePeripheral Nervous System Diseases

CACNA1H ALOX12 ABCC1

6.07e-03542023C4721453
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

HGFAC AHCYL1 ABCA8 PLCB3 RABGGTA RASA2 FADS1

6.20e-033152027EFO_0004574, EFO_0004612
Diseaseecosanoids measurement

PECR ABCC1 FADS1

6.38e-03552023EFO_0020044
Diseasecortical thickness change measurement

FRMD4B CSMD1

6.64e-03182022EFO_0021501
DiseaseIdiopathic hypogonadotropic hypogonadism

WDR11 IL17RD

6.64e-03182022C0342384
Diseasespine bone size

GDF5 FADS1

6.64e-03182022EFO_0004508
Diseasediastolic blood pressure, systolic blood pressure

HGFAC AHCYL1 HDAC4 MAP1B SPEG RGL1 BTRC FNDC3B FBXL17 GRB10 LRP1

6.72e-0367020211EFO_0006335, EFO_0006336

Protein segments in the cluster

PeptideGeneStartEntry
LWRQDGVLAVTCAQE

ACOT8

291

O14734
VCGSWGLNEEERLIR

CHRND

16

Q07001
SELLRQCRGSEQVLW

CARD10

966

Q9BWT7
GRILQEQARLVWVEC

CARD10

1006

Q9BWT7
RWRRVAVGVNACVDV

ADPGK

71

Q9BRR6
DRCQKICDQWDRLGT

ACTN2

481

P35609
ICDQWDRLGTLTQKR

ACTN2

486

P35609
ANCTWIIITGERNRI

CSMD1

56

Q96PZ7
AQGCPRCIWLQREIE

CXorf49;

481

A8MYA2
ARTLQEWCVGCEVVL

COPS7A

171

Q9UBW8
QVCLCLGQLERSIAW

BAZ2A

1656

Q9UIF9
CRCQETIANLERWVK

ARC

96

Q7LC44
IQDIETIESNWRCGR

BTRC

276

Q9Y297
NTIRLWDIECGACLR

BTRC

486

Q9Y297
RLDGNAIVDFVRWLC

ARFGEF2

1081

Q9Y6D5
RWEEVCREQQCGSVN

CD5

311

P06127
GLAQWFNDLLLRCRE

DNAH11

4346

Q96DT5
ALCQLWRAIILRDDA

ADCK5

396

Q3MIX3
GRIWLDNVRCSGEEQ

CD5L

306

O43866
LAARLESCEAQLWVR

DNHD1

1371

Q96M86
RGLVRASVEAWEAVC

DNHD1

2561

Q96M86
DILCQGNELALWNCR

CD163L1

221

Q9NR16
IITACQEGLICTWAR

DMWD

616

Q09019
ACDGEVRIWNLTQRN

DCAF13

86

Q9NV06
RASILWLIGENCERV

AP3B1

496

O00203
RGCVLRNTEWCFGLV

ATP8B2

251

P98198
CVEANEWIDVLCRVS

RASA2

691

Q15283
EWIDVLCRVSRCNQN

RASA2

696

Q15283
WCDLCGREVLRQALR

RASSF5

136

Q8WWW0
GDRQEVEIRGCSLWC

C9orf64

271

Q5T6V5
VEIRGCSLWCVELIR

C9orf64

276

Q5T6V5
RNAIASILRAWLDQC

RGL1

141

Q9NZL6
CSKSCELGWQRRLVE

ADAMTS1

866

Q9UHI8
ELGWQRRLVECRDIN

ADAMTS1

871

Q9UHI8
WRACVVRCDPEIQEL

IQCK

226

Q8N0W5
ILWQAAEICRRLNGV

INPP4A

876

Q96PE3
ENLALRGRCQEAWVL

RANGRF

91

Q9HD47
RGVQACARLQQLLEW

RADIL

666

Q96JH8
ALLCSGAEWRLCEVV

CD6

126

P30203
RLCQENQWLRDELAG

KLC4

111

Q9NSK0
LCDLERERWAVIQGQ

MISP

136

Q8IVT2
CNCLPETVRRGTELW

NOTCH2NLB

246

P0DPK3
WEECQRQLLLGLFCT

PNPLA2

436

Q96AD5
EGRELSLRDLLNWCN

MDN1

541

Q9NU22
SAQLCLELEAWERGR

GDF5

306

P43026
GWNCLAERAACSVVR

GPR6

206

P46095
WSRLQETGLRGKCEC

HDAC4

686

P56524
LNVDCEIVRTWIGNR

HDX

476

Q7Z353
DFSLCREGQREWVIQ

IL17RD

396

Q8NFM7
DIQGSRRCNLDWLTI

LRP12

96

Q9Y561
LGIRSWDTNLIECNL

MAP1B

61

P46821
WNLIVIICRIFEDGN

KIAA0825

1016

Q8IV33
CIQQWGDSVLGRRCR

INTS1

1786

Q8N201
DDVRCAGWERNLLEC

HHIPL1

741

Q96JK4
PWVCDCRLRGLVQFV

LRIT2

201

A6NDA9
VRCLEEWQEAGVNGR

NLRP10

106

Q86W26
SWAEAVRLGLEGCQR

EXOSC6

236

Q5RKV6
RERIELAATLCLEGW

FOXL2NB

146

Q6ZUU3
DRVCLWIGRQCDGTD

LRP1

3706

Q07954
IRCDCVIRWANATGT

LRRN2

371

O75325
GVWCENCNARLVELK

KIF26B

126

Q2KJY2
SGWELGCFRLCLRQV

FAM185A

6

Q8N0U4
QCLTERAIGWQDRAR

KDM5D

1266

Q9BY66
RIVWVCDGRCLLVSG

CORO7

686

P57737
CRLVCLRWKELVDGA

FBXO2

71

Q9UK22
LVCRQWQAVSRDEFL

FBXW5

31

Q969U6
RECVRGLWAGQQQEL

PCNX3

1731

Q9H6A9
NARVLDWICRRLEGE

PCK2

551

Q16822
ARRLVACGSIWQGIC

PLXNA3

106

P51805
CILGAVLRIRSAQAW

OR2V1

221

Q8NHB1
RDDWQRRCTEIVAID

PARG

811

Q86W56
ESLQRQACETLRDWL

PEX5

416

P50542
ALEWACSGIRINCVA

PECR

186

Q9BY49
RLWDIECGACLRVLE

FBXW11

426

Q9UKB1
LQVLRLTENPWRCDC

LRRC24

196

Q50LG9
RWGRTQLLARTCCEL

LRRC14B

131

A6NHZ5
ICQQEWVGERCLKSL

MED12

1286

Q93074
VGDCLRQQLGSRLAW

TUBGCP3

191

Q96CW5
DQRVALWRAAVACLV

MSLNL

151

Q96KJ4
QGLRELWDSVLRASC

FANCG

116

O15287
QAWCREITEVGLCQA

ALOX12

496

P18054
QADIRINGWAVECRV

PCCA

386

P05165
VTCWQRGEIRDACAE

CRLF2

206

Q9HC73
RWARVRQGHVEQCEC

HGFAC

216

Q04756
RRVAGAVWVLVLACQ

P2RY2

151

P41231
AQEQAALREECTRLW

PCNT

1376

O95613
CWDRLLLQEVASTRG

DQX1

146

Q8TE96
WEEQCIIQGCKLNRL

IAH1

141

Q2TAA2
CQEQIGWRNVSRLLV

ITGB7

271

P26010
WEIQRQLCAEGLCTQ

PAX4

101

O43316
QEDETICSVRRFLWG

GPRC5B

116

Q9NZH0
CAEVVWRCGNTQLRV

OBSCN

1836

Q5VST9
RQALLWGCRCVELDV

PLCB3

351

Q01970
LRACHQVLRTWCGLQ

FRMD4B

36

Q9Y2L6
LWEVQDGRRLQVGCA

CMPK2

176

Q5EBM0
ARLAAAWCLRCVAVA

HEATR5B

461

Q9P2D3
CAEIDLFRAAVRWLQ

KLHL26

221

Q53HC5
TWRQGDVECQRTECI

C6

691

P13671
GLCDQLAREILRWSQ

CPLANE1

891

Q9H799
GQEVWADELCQRRCT

FCGBP

811

Q9Y6R7
VIEDWRAQVGCEITC

FCGBP

1936

Q9Y6R7
RVTQLEGNSCEILWE

FNDC3B

1061

Q53EP0
LNLCLNWIINDRCVE

FBXL17

571

Q9UF56
NLSVENAWGILRCVI

EIF3D

481

O15371
TQCREGNAVAVRLWL

ILK

6

Q13418
RDQVQLGLDWQRRCD

CCDC57

421

Q2TAC2
AQRSGCEERWLVIDR

FADS1

26

O60427
LRIVLENRDRVGCVW

GBF1

1161

Q92538
TDRVLQWERIDCQGI

KLHDC2

126

Q9Y2U9
EDSEIRCLSQRWQRG

KHK

26

P50053
LRLLCAEDEQTRTCW

GRB10

376

Q13322
RDRGLSEQEAWAVCL

KNDC1

46

Q76NI1
ELGLSSWLVEQCRQL

DDX49

6

Q9Y6V7
QRLRCGISWSSEEIE

HOMEZ

106

Q8IX15
IWSRLQERGLRSQCE

HDAC7

551

Q8WUI4
LAWENLQCLRERGID

FDXACB1

46

Q9BRP7
VAALRGRLVWCEERQ

HPS6

131

Q86YV9
IVGVQLWAGLLRNRC

CACNA1H

246

O95180
RTDICQGELGDCWLL

CAPN9

86

O14815
NCTQLGEQCWTARIR

PSCA

31

O43653
GEQCWTARIRAVGLL

PSCA

36

O43653
ILQQGERALWCSRRD

INPP5F

11

Q9Y2H2
VIDLRLCNWVSRRAD

EIF4G3

976

O43432
TQRAWGLQEIRDCLI

CTU2

491

Q2VPK5
CWIVCTVLRQQLELG

NLRP6

391

P59044
DGGLARTVCQRCWLL

NOA1

171

Q8NC60
CRDTLRDWCQQLGLS

DPPA2

96

Q7Z7J5
RRLCTNLVVNCWVLG

OR11G2

176

Q8NGC1
LSWLRECLDNRVGVN

OSTF1

86

Q92882
WREISVCGNVFSLRE

PELI1

206

Q96FA3
DWRQLCGVAFLRLED

PKN3

376

Q6P5Z2
LQGWRTQLRQCTVHC

OTOG

406

Q6ZRI0
GRCWLDALELALRCS

OSBPL5

231

Q9H0X9
NRWLAVRLECVGNCI

ABCC1

1196

P33527
QRSSQRIGELEWSLC

GOLGA8A

191

A7E2F4
VNTDVGRCRAWLRLA

PLEKHM1

111

Q9Y4G2
RFGCVVCRWIAQDLS

PRXL2B

41

Q8TBF2
LQEWADTCCRGLRSV

RASL10B

71

Q96S79
SEQLNRCIRWADAVV

RASL11B

101

Q9BPW5
GNLAVLWVLSNCARR

RXFP4

56

Q8TDU9
RVNQAIWLLCTGARE

RPS5

146

P46782
LVCRDCRIQESNGTW

SYTL4

86

Q96C24
WILSRLALAAQECER

VARS2

781

Q5ST30
VRLWDVLNGNCVRIF

TAF5

651

Q15542
AIWEAQKVLDRGCLR

SFI1

741

A8K8P3
RATEALCWAEGQRLF

UTP4

61

Q969X6
DQLQKLGERWTAVCR

UTRN

501

P46939
ILEERLCVLNAGWSR

UTRN

1621

P46939
QWQKCRLLLRSEGEG

SH2B1

286

Q9NRF2
DLASVWCQCGELELR

XAB2

431

Q9HCS7
DEGQLICWRCERAPQ

TRIM38

106

O00635
ALKRGCRCVEVDVWD

PLCD4

326

Q9BRC7
LCLAGRRRSVQWCAV

LTF

16

P02788
RARVVWCAVGEQELR

LTF

361

P02788
LLLAQCNSDERAWRL

TMEM140

101

Q9NV12
SALWRARNQGCDRII

NXPE2

201

Q96DL1
VQEQASWVCRCEDRV

RFX1

786

P22670
SWVCRCEDRVVQRLE

RFX1

791

P22670
LIETLCALGAQCRWS

AHCYL1

161

O43865
AALCRDWQVLQALII

SLC22A23

336

A1A5C7
CVLLKGRQEGWCRDS

RABGGTA

331

Q92696
CRCAQVSRAWNVLAL

FBXL20

46

Q96IG2
NCQKASREWQGRDLL

GIMAP7

46

Q8NHV1
DWRIGDALCRITALV

GPR183

96

P32249
NLLVICVNWRGSGRA

GPR182

71

O15218
CEGLRTQIRELWDRL

PRC1

236

O43663
HLQCCRRVLENRWLG

MYCBP2

4451

O75592
GTLCWNRFAQIRAEL

PRAMEF27

426

A3QJZ7
RITCGCWNAENLLAL

WDR19

141

Q8NEZ3
VISNWVRVEERDCCN

MED13

1216

Q9UHV7
GLAQCAELCWQLRGE

SCP2

361

P22307
AELCWQLRGEAGKRQ

SCP2

366

P22307
EERLRDQCGWWVVLL

RHBDL1

396

O75783
GCFLENETLWAERLC

STRC

471

Q7RTU9
WQLSEQLRCLELQGE

ARHGAP4

26

P98171
GRCQELLAWAQERQE

SPTBN5

3321

Q9NRC6
CAESWGLQKLRQRLE

SPTBN5

3416

Q9NRC6
GGVALWRQQICAIAR

ABCA8

836

O94911
WELERTNQSGLERCE

ACVR2B

36

Q13705
TNQSLVELWGLLDCR

CLEC17A

236

Q6ZS10
WLVCTCVKQRLERGE

NLRP9

341

Q7RTR0
LRRLLAQECAVCGWA

RNF31

691

Q96EP0
QEEIVRGDVRSCRWL

XIRP2

831

A4UGR9
RCVLRSGEWRSEEQL

TMTC4

456

Q5T4D3
VRKDGRRWCTDLQLE

ZNF30

76

P17039
RRWCTDLQLEDDTIG

ZNF30

81

P17039
DRSCDIGNFELLWRQ

TTLL8

571

A6PVC2
LGQDLCRTTIVRLWE

PLAUR

41

Q03405
DGTIRLWSLGQQRCI

WDR48

231

Q8TAF3
VEAQVVWRSCRGALL

SPEG

1416

Q15772
WCSDQVIVQRCLAGK

SLC5A2

291

P31639
QLISCRNWRAAVDLC

TRAPPC12

386

Q8WVT3
RNWRAAVDLCGRLLT

TRAPPC12

391

Q8WVT3
RLLCVVAGESVNIRW

PAPLN

1151

O95428
WCETNLRRCISEQHR

RREB1

301

Q92766
EELNLWVRGCRAALL

PRPH2

241

P23942
AQQDLRLCVGCGWVR

TMEM158

136

Q8WZ71
QRWCELLQESAAVGR

STX10

26

O60499
ARCLWEESRLLQTAA

STAT3

106

P40763
KGRVRLLNNWDVCAD

RBP4

76

P02753
NETLVGDCRRVIWRD

SYT15B

306

X6R8R1
GDCRRVIWRDLEAES

SYT15B

311

X6R8R1
DASIRRWQITGECLE

PLAA

211

Q9Y263
LTWRSQDVENCAVRG

SEMA6C

101

Q9H3T2
RIEGALNLLQCTWEG

ST7L

451

Q8TDW4
CVDNTLTRIRQGWER

STEAP4

441

Q687X5
DAWDLRGAGVVCRQL

SCART1

461

Q4G0T1
LIDWLIAQGDCRTRE

PREX2

516

Q70Z35
TRLCRWPALIECGVN

STH

16

Q8IWL8
WLGCEAIVRQRERES

SGSM1

661

Q2NKQ1
LIVRRCEAQKWGPEC

TEK

206

Q02763
WCLTPADRGLCRANE

TFPI

216

P10646
RCRSECQWERIPELV

TTC7B

16

Q86TV6
RECISGRQWENLQGI

ZKSCAN2

706

Q63HK3
GCFLENETLWAERLC

STRCP1

471

A6NGW2
GCVLEWVRNIVANRL

PLBD2

341

Q8NHP8
LILEEWGCQNLARRN

ZKSCAN1

236

P17029
DLQLWCNLRSVARGQ

UNQ5830/PRO19650/PRO19816

76

Q6UY13
SLIWIRDNNIEECGL

WWP1

706

Q9H0M0
GRNVTFRILDVDWCT

WDR11

791

Q9BZH6
CACWTQDGLRLVVAV

WDCP

161

Q9H6R7
CWSALQLRLADRDLV

XKRX

326

Q6PP77
CRRCITEHWVRQEAQ

TRIM62

31

Q9BVG3
DCTIRRWDVLTGQCL

WDR86

76

Q86TI4
CARCDLRENLWLNLT

USP13

211

Q92995
EREVQQCSRVLGWVA

TRPM4

1176

Q8TD43
QCSRVLGWVAEALSR

TRPM4

1181

Q8TD43
LLREWLDCCVTEGGV

ZRANB1

646

Q9UGI0
QARICGSLQALDTWR

nan

31

Q96M85
EALQCLTERAISWQG

KDM5C

1276

P41229
AVSWEAGARAVLRCQ

MXRA8

41

Q9BRK3