Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionHMG box domain binding

HOXA3 POU3F3

6.94e-0523112GO:0071837
GeneOntologyBiologicalProcessnerve development

HOXA3 MNX1

1.48e-03109112GO:0021675
GeneOntologyBiologicalProcesspattern specification process

HOXA3 MNX1 SYNGAP1

2.34e-03526113GO:0007389
GeneOntologyBiologicalProcessregulation of mRNA processing

SAFB2 SF3B4

3.06e-03158112GO:0050684
GeneOntologyBiologicalProcessendocrine system development

HOXA3 MNX1

3.18e-03161112GO:0035270
GeneOntologyCellularComponentchromatin

HOXA3 MNX1 PPP1R10 FOXB2 POU3F3

5.69e-041480115GO:0000785
DomainHomeobox_CS

HOXA3 MNX1 POU3F3

1.11e-04186103IPR017970
DomainHomeobox

HOXA3 MNX1 POU3F3

2.18e-04234103PF00046
DomainHOMEOBOX_1

HOXA3 MNX1 POU3F3

2.24e-04236103PS00027
DomainHOX

HOXA3 MNX1 POU3F3

2.27e-04237103SM00389
DomainHomeobox_dom

HOXA3 MNX1 POU3F3

2.32e-04239103IPR001356
DomainHOMEOBOX_2

HOXA3 MNX1 POU3F3

2.32e-04239103PS50071
Domain-

HOXA3 MNX1 POU3F3

3.82e-042831031.10.10.60
DomainHomeodomain-like

HOXA3 MNX1 POU3F3

6.09e-04332103IPR009057
DomainHomeobox_metazoa

HOXA3 MNX1

1.01e-0390102IPR020479
DomainRRM_1

SAFB2 SF3B4

5.24e-03208102PF00076
DomainRRM

SAFB2 SF3B4

5.69e-03217102SM00360
DomainRRM_dom

SAFB2 SF3B4

6.21e-03227102IPR000504
DomainRRM

SAFB2 SF3B4

6.37e-03230102PS50102
Domain-

SAFB2 SF3B4

7.14e-032441023.30.70.330
DomainNucleotide-bd_a/b_plait

SAFB2 SF3B4

7.95e-03258102IPR012677
Pubmed

Hox3 genes coordinate mechanisms of genetic suppression and activation in the generation of branchial and somatic motoneurons.

HOXA3 MNX1

1.23e-051711212954718
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SAFB2 SF3B4 PPP1R10 SYNGAP1 POU3F3

1.91e-05120311529180619
Pubmed

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.

HOXA3 POU3F3

2.50e-052411216582099
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SAFB2 MNX1 PPP1R10

8.38e-0528311330585729
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SAFB2 SF3B4 PPP1R10 SYNGAP1

2.58e-04108211438697112
InteractionCAPN13 interactions

SAFB2 PPP1R10

3.02e-051992int:CAPN13
InteractionRSPH9 interactions

SAFB2 PPP1R10

3.02e-051992int:RSPH9
InteractionFNDC4 interactions

SAFB2 PPP1R10

3.71e-052192int:FNDC4
InteractionRNF4 interactions

SAFB2 SF3B4 PPP1R10 SYNGAP1 POU3F3

1.66e-04141295int:RNF4
InteractionZFP41 interactions

SAFB2 PPP1R10

2.79e-045792int:ZFP41
InteractionLRRC7 interactions

SF3B4 SYNGAP1

2.89e-045892int:LRRC7
Cytoband6p21.3

PPP1R10 SYNGAP1

1.57e-032501126p21.3
CytobandEnsembl 112 genes in cytogenetic band chr6p21

PPP1R10 SYNGAP1

6.17e-03503112chr6p21
GeneFamilyHOXL subclass homeoboxes

HOXA3 MNX1

3.60e-0452102518
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

WDR81 PPP1R10

4.25e-03181102694
GeneFamilyRNA binding motif containing

SAFB2 SF3B4

5.84e-03213102725
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma-3|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

PHGR1 MNX1

5.64e-04146112e55b4acecf4e363b5afa287c747c2e58c4597f3a
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

PHGR1 MNX1

5.88e-0414911292a8931a51db619fb5f0638d319c02e7838f6559
ToppCell10x5'-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

HOXA3 TRIM45

6.35e-0415511283430a64c2cb5ad29caa3dacba76c28dd204ac40
ToppCellfacs-Marrow-T-cells-24m-Hematologic-MPP_Fraction_B|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDR81 PPP1R10

6.77e-04160112b3f7ef7e682b48a83ca425f5c439336e96168300
ToppCellBL-critical-LOC-Epithelial-FOXN4+|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MNX1 TRIM45

6.77e-041601123f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

6.94e-041621129f568836199a05f696294caac1ea3fa413984423
ToppCellTCGA-Colorectal|World / Sample_Type by Project: Shred V9

PHGR1 MNX1

7.28e-04166112c018cd8c7a82251c67e3dc812d4d21e527a43456
ToppCellfacs-Trachea-nan-18m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRIM45 POU3F3

7.37e-041671127b1fd19946cee67dae68f0f0d98420abcd532482
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

8.18e-0417611271f96cace3f20fbef975037f4deff9b82b0282a1
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

8.27e-041771125bccc7a74019eae8afd977a9c9134d884857ac27
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HOXA3 TRIM45

8.36e-04178112c87945146b2734141f07b39d268e0d8086ee0364
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

8.55e-041801126b1606238417490e0d9930870a7827419d1c3737
ToppCellfacs-Heart-LV-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SAFB2 PHGR1

8.74e-041821126dff753d65ba45db81f3cc0c9f59e1779d490955
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

8.93e-04184112886d2d9bf2fe31207f17e3edc309ef44029924e1
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

8.93e-04184112936b39377eebea3961d702532779f6cd27953be7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HOXA3 POU3F3

9.03e-041851126da9a06e1514d5d5f47359a14637f02539846096
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HOXA3 POU3F3

9.03e-041851124a188e2566a75d1b4f3c879a8c241c277c4b451c
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

9.03e-04185112eb78614c4acf8d2ce7874d7e51e16997b76127ef
ToppCellfacs-MAT-Fat-18m|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHGR1 SF3B4

9.32e-041881127f0cda7aab442aa9511d4c35569ec2389e014a71
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

9.32e-04188112ed074572e61d97c139fb1636a78c9b71e2c44ce0
ToppCellILEUM-inflamed-(5)_Plasma-(5)_IgA_plasma_cells|(5)_Plasma / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PHGR1 PPP1R10

9.42e-04189112a0634d72bfdd5f93877724ed6480b50a3a046f71
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

9.72e-041921125692bd57093852d442400383850f416c497dcc7d
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

1.01e-031961124deaadb9796b907b7480fb7af5ed76ebad240850
ToppCell5'-GW_trimst-1.5-SmallIntestine-Epithelial-epithelial_progenitor_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHGR1 MNX1

1.05e-03200112eef5f6bd9ff5d985def8befcf45786234317f144
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related-Oligodendrocyte/OPC|GW12 / Sample Type, Dataset, Time_group, and Cell type.

SAFB2 POU3F3

1.05e-032001124db894cfb80fd1f9e01133f345eefd78edd4bc43
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-OPC_related|GW12 / Sample Type, Dataset, Time_group, and Cell type.

SAFB2 POU3F3

1.05e-03200112d46a19274c2836ce7494790ce513764dedcadc79
DiseaseIntellectual Disability

SYNGAP1 POU3F3

1.15e-02447112C3714756

Protein segments in the cluster

PeptideGeneStartEntry
SAPGAGPGGHLHPHH

FOXB2

126

Q5VYV0
SGHHHGPGPGEPHPT

HOXA3

406

O43365
TGGGHGGPHHHAHPG

MNX1

106

P50219
KGHCHCGGHGHPPGH

PHGR1

6

C9JFL3
HHAQGPPHHGGGGGG

POU3F3

286

P20264
GCGHGHKGHPGHPHW

TRIM45

536

Q9H8W5
GGGGGHGPPSSHHHH

SYNGAP1

946

Q96PV0
GDDRHGHGGPPERHG

SAFB2

801

Q14151
RPHEGPGHGGPHGHR

PPP1R10

846

Q96QC0
PGHGGPHGHRPHDVP

PPP1R10

851

Q96QC0
PPHEHRGHDGPGHGG

PPP1R10

876

Q96QC0
PGHGGGGHRGHDGGH

PPP1R10

886

Q96QC0
PGAGHPGHGHSHPHP

SF3B4

281

Q15427
AGGAGGGEPPHVPHH

WDR81

426

Q562E7