Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmetalloendopeptidase activity

MMP24 ADAMTS14 ADAMTS3

4.97e-04120263GO:0004222
GeneOntologyMolecularFunctionsulfur compound binding

NAV2 SCP2 FGF7 ADAMTS3

7.58e-04323264GO:1901681
GeneOntologyMolecularFunctionheparin binding

NAV2 FGF7 ADAMTS3

1.93e-03192263GO:0008201
GeneOntologyMolecularFunctionmetallopeptidase activity

MMP24 ADAMTS14 ADAMTS3

2.17e-03200263GO:0008237
GeneOntologyMolecularFunctionendopeptidase activity

MMP24 ADAMTS14 ADAMTS3 TMPRSS11A

2.18e-03430264GO:0004175
GeneOntologyBiologicalProcesscollagen catabolic process

MMP24 ADAMTS14 ADAMTS3

3.99e-0553263GO:0030574
HumanPhenoStage 5 chronic kidney disease

PKHD1 GANAB MYO1E INVS

5.36e-0513594HP:0003774
HumanPhenoAbsence of renal corticomedullary differentiation

PKHD1 INVS

5.80e-05792HP:0005564
HumanPhenoChronic kidney disease

PKHD1 GANAB MYO1E INVS

2.21e-0419494HP:0012622
HumanPhenoEnlarged kidney

PKHD1 GANAB INVS

2.72e-047893HP:0000105
HumanPhenoSpontaneous pneumothorax

PKHD1 ADAMTS3

3.29e-041692HP:0002108
MousePhenoproximal convoluted tubule brush border loss

PKHD1 MYO1E INVS

9.68e-0712243MP:0011352
MousePhenoabnormal proximal convoluted tubule brush border morphology

PKHD1 MYO1E INVS

2.98e-0617243MP:0011350
MousePhenoabnormal papillary duct morphology

PKHD1 FGF7

2.82e-055242MP:0011331
MousePhenodilated pancreatic duct

PKHD1 INVS

7.86e-058242MP:0009144
MousePhenoabnormal kidney collecting duct morphology

PKHD1 FGF7 INVS

9.85e-0553243MP:0004754
MousePhenoabnormal pancreatic duct morphology

PKHD1 INVS

1.85e-0412242MP:0009143
MousePhenoabnormal kidney interstitium morphology

PKHD1 MYO1E INVS

1.98e-0467243MP:0011425
MousePhenoabnormal proximal convoluted tubule morphology

PKHD1 MYO1E INVS

2.99e-0477243MP:0004756
DomainMetalloPept_cat_dom

MMP24 ADAMTS14 ADAMTS3

1.69e-0481253IPR024079
Domain-

MMP24 ADAMTS14 ADAMTS3

1.69e-04812533.40.390.10
DomainPLAC

ADAMTS14 ADAMTS3

2.90e-0419252IPR010909
DomainPLAC

ADAMTS14 ADAMTS3

2.90e-0419252PS50900
DomainZINC_PROTEASE

MMP24 ADAMTS14 ADAMTS3

2.96e-0498253PS00142
DomainADAM_spacer1

ADAMTS14 ADAMTS3

4.28e-0423252IPR010294
DomainADAM_spacer1

ADAMTS14 ADAMTS3

4.28e-0423252PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS14 ADAMTS3

4.66e-0424252IPR013273
DomainPeptidase_M12B_N

ADAMTS14 ADAMTS3

1.24e-0339252IPR002870
DomainPep_M12B_propep

ADAMTS14 ADAMTS3

1.24e-0339252PF01562
DomainDISINTEGRIN_1

ADAMTS14 ADAMTS3

1.30e-0340252PS00427
DomainADAM_MEPRO

ADAMTS14 ADAMTS3

1.30e-0340252PS50215
DomainDISINTEGRIN_2

ADAMTS14 ADAMTS3

1.30e-0340252PS50214
DomainReprolysin

ADAMTS14 ADAMTS3

1.30e-0340252PF01421
DomainPeptidase_M12B

ADAMTS14 ADAMTS3

1.30e-0340252IPR001590
DomainCYSTEINE_SWITCH

MMP24 ADAMTS14

1.37e-0341252PS00546
DomainDisintegrin_dom

ADAMTS14 ADAMTS3

1.37e-0341252IPR001762
DomainPept_M10_metallopeptidase

MMP24 ADAMTS14

1.50e-0343252IPR001818
DomainTSP_1

ADAMTS14 ADAMTS3

3.20e-0363252PF00090
DomainTSP1

ADAMTS14 ADAMTS3

3.40e-0365252SM00209
DomainTSP1_rpt

ADAMTS14 ADAMTS3

3.40e-0365252IPR000884
DomainTSP1

ADAMTS14 ADAMTS3

3.40e-0365252PS50092
DomainCH

NAV2 MICAL1

3.40e-0365252SM00033
DomainCH

NAV2 MICAL1

3.93e-0370252PF00307
DomainIQ

MYO1E INVS

4.04e-0371252PF00612
Domain-

NAV2 MICAL1

4.04e-03712521.10.418.10
DomainCH

NAV2 MICAL1

4.26e-0373252PS50021
DomainCH-domain

NAV2 MICAL1

4.50e-0375252IPR001715
DomainIQ_motif_EF-hand-BS

MYO1E INVS

6.41e-0390252IPR000048
DomainIQ

MYO1E INVS

6.83e-0393252PS50096
Pubmed

Cloning and characterization of ADAMTS-14, a novel ADAMTS displaying high homology with ADAMTS-2 and ADAMTS-3.

ADAMTS14 ADAMTS3

1.61e-06326211741898
Pubmed

The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology.

ADAMTS14 ADAMTS3

1.61e-06326225863161
Pubmed

Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.

ADAMTS14 ADAMTS3

3.22e-06426222205175
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

GANAB MAPK6 TRAPPC8 MYO1E

5.39e-0615626430409884
Pubmed

Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis.

ADAMTS14 ADAMTS3

8.05e-06626216556917
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

GANAB R3HDM1 AVL9 ARHGAP21 NISCH

1.15e-0540726512693553
Pubmed

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation.

PKHD1 FGF7 INVS

4.90e-059526320843830
Pubmed

ADAMTS2 promotes radial migration by activating TGF-β signaling in the developing neocortex.

ADAMTS14 ADAMTS3

5.61e-051526238871984
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

DHX15 MICAL1 MYO1E PDK1 ARHGAP21 NISCH TTC21A

6.50e-05143126737142655
Pubmed

Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3 in Perinatal Survival and Postnatal Growth Using New Genetically Engineered Mouse Models.

MAPK6 MYO1E

2.47e-043126230642949
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

GANAB PDK1 ARHGAP21 NISCH

2.56e-0442126436976175
Pubmed

Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model.

PKHD1 INVS

3.33e-043626233737325
Pubmed

A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors.

NAV2 GANAB

6.44e-045026223703321
Pubmed

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate.

FGF7 MYO1E

6.96e-045226226984772
Pubmed

Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

PKHD1 INVS

6.96e-045226220301743
InteractionANAPC5 interactions

MAPK6 MYO1E ANO6 ANAPC4

2.38e-05138254int:ANAPC5
InteractionWDFY4 interactions

GANAB MAPK6 TRAPPC8 MYO1E

2.59e-05141254int:WDFY4
CytobandEnsembl 112 genes in cytogenetic band chr4p15

DHX15 ANAPC4

2.66e-03135262chr4p15
CytobandEnsembl 112 genes in cytogenetic band chr4q13

ADAMTS3 TMPRSS11A

3.58e-03157262chr4q13
CytobandEnsembl 112 genes in cytogenetic band chr15q21

FGF7 MAPK6

4.52e-03177262chr15q21
CytobandEnsembl 112 genes in cytogenetic band chr11q12

GANAB FADS2B

1.62e-02345262chr11q12
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS14 ADAMTS3

1.41e-041917250
CoexpressionGSE9037_CTRL_VS_LPS_4H_STIM_BMDM_UP

SCP2 MICAL1 MMP24 PDK1 ANAPC4

1.42e-06200265M5803
CoexpressionNUYTTEN_EZH2_TARGETS_UP

SCP2 FGF7 ADAMTS14 MAPK6 MYO1E PTPRR PDK1 ARHGAP21

4.70e-061033268M4196
CoexpressionGSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP

DHX15 PDK1 NISCH ANAPC4

3.11e-05184264M9005
ToppCellE15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

FGF7 PTPRR INVS

9.65e-05154263e65e4636646164610f33f7bbac0d879a3ea55986
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGF7 MICAL1 PDK1

1.56e-041812634e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGF7 MICAL1 PDK1

1.56e-04181263ad30c01290fb98adbd0caed301a584761212c977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FGF7 MICAL1 PDK1

1.56e-041812633a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCellP03|World / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 SCP2 NISCH

1.66e-04185263a07dbe1f76e40734a28826423a5cc64b8e56af5e
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

R3HDM1 ADAMTS3 PTPRR

1.69e-0418626384ba666237c18189d7e7556bd92dd953af733c00
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 NAV2 MYO1E

1.71e-0418726387b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 NAV2 MYO1E

1.71e-0418726342a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 NAV2 MYO1E

1.71e-0418726364afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellControl-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

MYO1E ADAMTS3 ANO6

1.71e-041872635429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-RG-RG-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

DHX15 FGF7 PTPRR

1.79e-041902637a560d046aeff979cdf543c519e4e51280f5e232
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 NAV2 MYO1E

1.82e-041912635717809a1476c20f65bce722c5a57cff92ee0d7a
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 NAV2 MYO1E

1.82e-041912639032aa974aa1b7b1095b8d1b58dcb087358a5001
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-alveolar_fibroblast_Wnt2-pa|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NAV2 FGF7 NISCH

1.85e-041922630afb9dbe468e0be442c326e11c5fc0f699b32f23
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NAV2 FGF7 ADAMTS3

1.88e-04193263261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1|TCGA-Endometrium / Sample_Type by Project: Shred V9

NAV2 MAPK6 R3HDM1

1.88e-04193263c2673d86f7d7b849788036032a93a6d136a70040
ToppCellLV-14._Fibroblast_III|LV / Chamber and Cluster_Paper

NAV2 FGF7 PDK1

1.91e-04194263927c26aea0147f7a4b8fb3f192de4de263f1b978
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NAV2 FGF7 ADAMTS3

1.91e-04194263c49f72441b3557e2c3a9c4239e68c0cf0652814b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 SKIL MYO1E

1.94e-04195263938b31dbf1674ee6fd0123bc88391ddcaf151217
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NAV2 FGF7 ADAMTS3

1.94e-041952633c3703f092b6fc1b7333426fb5e2823bfb74bb57
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1 SKIL MYO1E

1.94e-04195263d39e9e6544f49e677ebe528c6fe60b99a3630e30
ToppCellPND01-03-samps-Mesenchymal-Matrix_fibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

NAV2 FGF7 NISCH

1.97e-0419626354f4cf778f95a9ff662e5c7520916a25e605bf95
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS14 MYO1E PTPRR

2.03e-04198263efdbac7a3a02bff4ca48841772e0c136556c2b9b
ToppCellControl_saline-Epithelial_alveolar-AT_1-Differentiating_AT1|Control_saline / Treatment groups by lineage, cell group, cell type

PKHD1 NAV2 MICAL1

2.03e-0419826385f424cd9bb3117c9e322031024aabb87696ce47
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS14 MYO1E PTPRR

2.03e-04198263a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCellIPF-Endothelial-VE_Peribronchial|Endothelial / Disease state, Lineage and Cell class

NAV2 MYO1E ADAMTS3

2.03e-04198263b8bd1ba268480f54451648e01631b615a3401144
ToppCellcontrol-unassigned|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AVL9 PDK1 ANAPC4

2.06e-041992635db7c8089172ac8e796613b3cef618d87007a0ab
ToppCellKidney-Tubules|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

PKHD1 NAV2 SCP2

2.09e-042002630726456906e078244a9cff35aee8c5bce4566fb1
Diseaserespiratory symptom change measurement, response to placebo

DHX15 NAV2

9.30e-0517252EFO_0008344, EFO_0010068
Diseaseheart rate variability measurement, response to antipsychotic drug

NAV2 SKIL

6.97e-0446252EFO_0008003, GO_0097332
Diseaseblood osmolality measurement

PKHD1 NAV2

1.11e-0358252EFO_0007967
Diseasesynophrys measurement

NAV2 PTPRR

1.52e-0368252EFO_0007906
DiseaseAlveolitis, Fibrosing

FGF7 SKIL

2.25e-0383252C4721507
DiseasePulmonary Fibrosis

FGF7 SKIL

2.36e-0385252C0034069
Diseaseamino acid measurement

MAPK6 MYO1E PTPRR NISCH

2.38e-03678254EFO_0005134
DiseaseCiliopathies

PKHD1 INVS

3.91e-03110252C4277690
Diseaseseasonal gut microbiome measurement

NAV2 PTPRR

4.05e-03112252EFO_0007753
Diseasecortical surface area measurement

PKHD1 NAV2 MAPK6 ADAMTS3 ARHGAP21

4.84e-031345255EFO_0010736
Diseasecognitive function measurement

DHX15 PKHD1 GANAB ARHGAP21 ANAPC4

6.34e-031434255EFO_0008354
Diseaseurate measurement

PKHD1 ANO6 NISCH ANAPC4

6.40e-03895254EFO_0004531
Diseaseserum gamma-glutamyl transferase measurement

PKHD1 NAV2 FGF7 ARHGAP21

6.89e-03914254EFO_0004532
Diseaseresting heart rate

DHX15 ARHGAP21

7.04e-03149252EFO_0004351

Protein segments in the cluster

PeptideGeneStartEntry
KFPFLWNNKTSNLHY

ANAPC4

571

Q9UJX5
YHAFKQNHESVQWCY

DHX15

631

O43143
RNSYYVHQNAKHSWV

ADAMTS14

621

Q8WXS8
HSPPQWKQNKYYCDH

R3HDM1

846

Q15032
PVYNKAAWKHYNTNH

PDK1

401

Q15118
GHPQEYKHNIYYWHV

ANO6

816

Q4KMQ2
QKWRQKHITYSIHNY

MMP24

161

Q9Y5R2
TEPCWQYSDHHENKY

MAPK6

421

Q16659
PQYHKIKDQLNYWSA

MICAL1

46

Q8TDZ2
KQGSHTQHVKHYWYT

PTPRR

536

Q15256
NYWHFEQHVKPNIYP

FADS2B

251

A8MWK0
NSHFEYQNTKHHWLP

ADAMTS3

621

O15072
YQNTKHHWLPYEHPD

ADAMTS3

626

O15072
KNTHNYRVWNSNKHP

AVL9

541

Q8NBF6
NHYNTYASAKWTHNG

FGF7

146

P21781
DKNKQTALHWSAYYN

INVS

146

Q9Y283
ESAKWHCYLHVNQKY

SKIL

321

P12757
WYDIQSYQKHHGPQT

GANAB

776

Q14697
YTDWANHYLAKSGHK

NAV2

91

Q8IVL1
KVHLYSAYPKNSWTH

PKHD1

2856

P08F94
WKNHKHSVNNPYSQF

SCP2

186

P22307
FWHQKNTDYNNSPFH

NISCH

1206

Q9Y2I1
TNYKLAWKYSHHANP

TTC21A

1256

Q8NDW8
HRIQHNSDYSYPKWF

TRAPPC8

171

Q9Y2L5
YSPNSHQHIDWKNYK

ARHGAP21

376

Q5T5U3
AHCFQKYKNPHQWTV

TMPRSS11A

226

Q6ZMR5
VYQYHWQSHNVKHSG

MYO1E

6

Q12965