Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	PRKCD APPL2 VAV2	2.62e-05	25	48	3	GO:0002433
GeneOntologyBiologicalProcess	Fc-gamma receptor signaling pathway involved in phagocytosis	PRKCD APPL2 VAV2	2.62e-05	25	48	3	GO:0038096
GeneOntologyBiologicalProcess	Fc receptor mediated stimulatory signaling pathway	PRKCD APPL2 VAV2	7.35e-05	35	48	3	GO:0002431
GeneOntologyBiologicalProcess	Fc-gamma receptor signaling pathway	PRKCD APPL2 VAV2	1.02e-04	39	48	3	GO:0038094
GeneOntologyCellularComponent	phagocytic vesicle membrane	SLC9A9 ATP6V0A1 ATP6V0D1 APPL2	3.94e-05	83	48	4	GO:0030670
GeneOntologyCellularComponent	endocytic vesicle membrane	SLC9A9 ATP6V0A1 ATP6V0D1 APPL2 HLA-DRB5	1.23e-04	212	48	5	GO:0030666
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0D1	2.30e-04	10	48	2	GO:0000220
GeneOntologyCellularComponent	proton-transporting V-type ATPase, V0 domain	ATP6V0A1 ATP6V0D1	3.36e-04	12	48	2	GO:0033179
GeneOntologyCellularComponent	phagocytic vesicle	SLC9A9 ATP6V0A1 ATP6V0D1 APPL2	4.61e-04	157	48	4	GO:0045335
GeneOntologyCellularComponent	early phagosome	SLC9A9 APPL2	4.62e-04	14	48	2	GO:0032009
GeneOntologyCellularComponent	endosome	JAK2 PRKCD SLC9A9 ATP6V0A1 ATP6V0D1 APPL2 HLA-DRB5 L1CAM VPS35L	1.19e-03	1167	48	9	GO:0005768
GeneOntologyCellularComponent	vacuolar proton-transporting V-type ATPase complex	ATP6V0A1 ATP6V0D1	1.62e-03	26	48	2	GO:0016471
GeneOntologyCellularComponent	proton-transporting two-sector ATPase complex, proton-transporting domain	ATP6V0A1 ATP6V0D1	1.62e-03	26	48	2	GO:0033177
GeneOntologyCellularComponent	endocytic vesicle	SLC9A9 ATP6V0A1 ATP6V0D1 APPL2 HLA-DRB5	1.82e-03	384	48	5	GO:0030139
GeneOntologyCellularComponent	proton-transporting V-type ATPase complex	ATP6V0A1 ATP6V0D1	2.01e-03	29	48	2	GO:0033176
Domain	USP_C	USP15 USP11	1.94e-05	3	48	2	IPR029346
Domain	USP7_C2	USP15 USP11	1.94e-05	3	48	2	PF14533
Domain	Ubiquitin_3	USP15 USP11	3.87e-05	4	48	2	PF14836
Domain	Ub_USP-typ	USP15 USP11	3.87e-05	4	48	2	IPR028135
Domain	DUSP	USP15 USP11	9.64e-05	6	48	2	SM00695
Domain	DUSP	USP15 USP11	9.64e-05	6	48	2	PF06337
Domain	-	USP15 USP11	1.35e-04	7	48	2	3.30.2230.10
Domain	DUSP	USP15 USP11	1.35e-04	7	48	2	PS51283
Domain	Pept_C19_DUSP	USP15 USP11	1.35e-04	7	48	2	IPR006615
Domain	Rap_GAP	TSC2 GARNL3	2.87e-04	10	48	2	PF02145
Domain	Rap_GAP_dom	TSC2 GARNL3	3.51e-04	11	48	2	IPR000331
Domain	RAPGAP	TSC2 GARNL3	3.51e-04	11	48	2	PS50085
Domain	SET	SMYD4 SETMAR	4.98e-03	41	48	2	PF00856
Domain	SET	SMYD4 SETMAR	6.23e-03	46	48	2	SM00317
Domain	SET_dom	SMYD4 SETMAR	7.32e-03	50	48	2	IPR001214
Domain	SET	SMYD4 SETMAR	7.32e-03	50	48	2	PS50280
Domain	C1_1	PRKCD VAV2	9.43e-03	57	48	2	PF00130
Domain	ZF_DAG_PE_1	PRKCD VAV2	1.18e-02	64	48	2	PS00479
Pubmed	A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia.	JAK2 PCM1	1.87e-06	2	48	2	16769584
Pubmed	Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity.	PRKCD TSC2	1.87e-06	2	48	2	30684133
Pubmed	t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.	JAK2 PCM1	1.87e-06	2	48	2	23372669
Pubmed	The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.	JAK2 PCM1	1.87e-06	2	48	2	15805263
Pubmed	Isolation and characterization of the mouse ubiquitin-specific protease Usp15.	USP15 USP11	1.87e-06	2	48	2	12532266
Pubmed	PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation.	JAK2 PCM1	1.87e-06	2	48	2	16034466
Pubmed	A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphoma.	JAK2 PCM1	1.87e-06	2	48	2	16424865
Pubmed	Evolutional change of karyotype with t(8;9)(p22;p24) and HLA-DR immunophenotype in relapsed acute myeloid leukemia.	JAK2 PCM1	1.87e-06	2	48	2	18594780
Pubmed	Should myeloid and lymphoid neoplasms with PCM1-JAK2 and other rearrangements of JAK2 be recognized as specific entities?	JAK2 PCM1	1.87e-06	2	48	2	24913195
Pubmed	The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.	JAK2 PCM1	1.87e-06	2	48	2	16091753
Pubmed	Requirement of Ca(2+) and PKCdelta for Janus kinase 2 activation by angiotensin II: involvement of PYK2.	JAK2 PRKCD	5.59e-06	3	48	2	11818507
Pubmed	Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.	USP15 USP11	5.59e-06	3	48	2	26503449
Pubmed	Phosphorylation of NLRC4 is critical for inflammasome activation.	PRKCD NLRC4	5.59e-06	3	48	2	22885697
Pubmed	Structural variability of the ubiquitin specific protease DUSP-UBL double domains.	USP15 USP11	5.59e-06	3	48	2	22001210
Pubmed	DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.	PRKCD NLRC4	1.86e-05	5	48	2	34860583
Pubmed	Stat1 associates with c-kit and is activated in response to stem cell factor.	JAK2 PRKCD	1.86e-05	5	48	2	9355737
Pubmed	Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.	PRKCD VAV2	2.79e-05	6	48	2	27926862
Pubmed	Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.	PRKCD NLRC4	2.79e-05	6	48	2	24516390
Pubmed	Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells.	JAK2 PRKCD	3.90e-05	7	48	2	19075017
Pubmed	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor.	USP15 USP11	5.19e-05	8	48	2	22706160
Pubmed	Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.	TOMM40 TNXB	5.19e-05	8	48	2	22694956
Pubmed	A mouse model for dominant collagen VI disorders: heterozygous deletion of Col6a3 Exon 16.	COL6A5 TNXB	5.19e-05	8	48	2	24563484
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	TOMM40 MGAT1 CLYBL TRPM7 TNXB PCM1 INPP4B ANKEF1 VPS35L	5.98e-05	1293	48	9	15342556
Pubmed	Activation of protein kinase C delta by IFN-gamma.	JAK2 PRKCD	6.67e-05	9	48	2	12817007
Pubmed	A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.	JAK2 PRKCD	8.33e-05	10	48	2	7690989
Pubmed	Protein kinase Cdelta regulates apoptosis via activation of STAT1.	JAK2 PRKCD	1.02e-04	11	48	2	15322115
Pubmed	Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.	JAK2 PRKCD	1.02e-04	11	48	2	7543024
Pubmed	Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development.	TSC2 APPL2	1.22e-04	12	48	2	20665729
Pubmed	Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.	JAK2 PRKCD	1.22e-04	12	48	2	12576423
Pubmed	Ser727/Tyr701-phosphorylated Stat1 is required for the regulation of c-Myc, cyclins, and p27Kip1 associated with ATRA-induced G0/G1 arrest of U-937 cells.	JAK2 PRKCD	1.22e-04	12	48	2	12637327
Pubmed	Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism.	JAK2 PRKCD	1.44e-04	13	48	2	14551213
Pubmed	Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.	JAK2 PRKCD	1.68e-04	14	48	2	11350938
Pubmed	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.	JAK2 HLA-DRB5 CXCR1	1.75e-04	78	48	3	21297633
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP15 USP11	1.94e-04	15	48	2	9827704
Pubmed	Christianson syndrome protein NHE6 modulates TrkB endosomal signaling required for neuronal circuit development.	SLC9A9 L1CAM	1.94e-04	15	48	2	24035762
Pubmed	Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.	JAK2 PRKCD	1.94e-04	15	48	2	11839738
Pubmed	Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.	USP15 USP11	2.50e-04	17	48	2	29299163
Pubmed	The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery.	ATP6V0A1 ATP6V0D1	2.50e-04	17	48	2	28793259
Pubmed	Introduction: V-ATPases 1992-1998.	ATP6V0A1 ATP6V0D1	2.81e-04	18	48	2	10340843
Pubmed	Animal plasma membrane energization by proton-motive V-ATPases.	ATP6V0A1 ATP6V0D1	2.81e-04	18	48	2	10440860
Pubmed	The vacuolar H+-ATPase: a universal proton pump of eukaryotes.	ATP6V0A1 ATP6V0D1	2.81e-04	18	48	2	9210392
Pubmed	Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.	TNXB HLA-DRB5	2.81e-04	18	48	2	19116923
Pubmed	Vacuolar and plasma membrane proton-adenosinetriphosphatases.	ATP6V0A1 ATP6V0D1	2.81e-04	18	48	2	10221984
Pubmed	Structure and properties of the vacuolar (H+)-ATPases.	ATP6V0A1 ATP6V0D1	2.81e-04	18	48	2	10224039
Pubmed	Structure, function and regulation of the vacuolar (H+)-ATPase.	ATP6V0A1 ATP6V0D1	3.14e-04	19	48	2	9442887
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TSC2 SETMAR ATP6V0A1 APPL2 TRPM7 USP11 PCM1 VPS35L	3.44e-04	1285	48	8	35914814
Pubmed	Lipofuscin is formed independently of macroautophagy and lysosomal activity in stress-induced prematurely senescent human fibroblasts.	ATP6V0A1 ATP6V0D1	3.49e-04	20	48	2	22982048
Pubmed	Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.	SLC9A9 DDX60L	3.85e-04	21	48	2	20708005
Pubmed	The vacuolar (H+)-ATPases--nature's most versatile proton pumps.	ATP6V0A1 ATP6V0D1	4.23e-04	22	48	2	11836511
Pubmed	Recombination in the class III region of the mouse major histocompatibility complex.	TNXB HLA-DRB5	4.23e-04	22	48	2	7916002
Pubmed	Proton translocation driven by ATP hydrolysis in V-ATPases.	ATP6V0A1 ATP6V0D1	4.23e-04	22	48	2	12788495
Pubmed	Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes.	ATP6V0A1 ATP6V0D1	4.23e-04	22	48	2	14580332
Pubmed	Neurotransmitter release: the dark side of the vacuolar-H+ATPase.	ATP6V0A1 ATP6V0D1	4.23e-04	22	48	2	14597263
Pubmed	USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.	USP15 USP11	4.23e-04	22	48	2	24850914
Pubmed	Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation.	ATP6V0A1 ATP6V0D1	4.23e-04	22	48	2	17662945
Pubmed	Receptor-mediated endocytosis: the intracellular journey of transferrin and its receptor.	ATP6V0A1 ATP6V0D1	5.48e-04	25	48	2	2874839
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	TSC2 APPL2 ADGRL2 TRPM7 VPS35L	6.42e-04	504	48	5	34432599
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	TSC2 TOMM40 DDX60L ATP6V0D1 RBM28 ADGRL2 PCM1 VPS35L	7.30e-04	1440	48	8	30833792
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	SMYD4 TSC2 USP11 PCM1	7.83e-04	300	48	4	28561026
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	CCPG1 ATP6V0A1 RBM28 ADGRL2 TRPM7 USP11 PIEZO1 PCM1	9.00e-04	1487	48	8	33957083
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TSC2 ATP6V0A1 ATP6V0D1 USP11	9.17e-04	313	48	4	38270169
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP15 USP11	9.58e-04	33	48	2	30323974
Pubmed	Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway.	ATP6V0D1 PCM1	9.58e-04	33	48	2	29149599
Pubmed	Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.	TOMM40 MGAT1	1.02e-03	34	48	2	19197348
Pubmed	USP15 Deubiquitinase Safeguards Hematopoiesis and Genome Integrity in Hematopoietic Stem Cells and Leukemia Cells.	USP15 USP11	1.08e-03	35	48	2	33378683
Pubmed	USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.	TSC2 USP11	1.20e-03	37	48	2	32133736
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	TSC2 CCPG1 ERMP1 ATP6V0A1 USP15 PIEZO1 L1CAM	1.23e-03	1201	48	7	35696571
Cytoband	9p24	JAK2 ERMP1	2.99e-05	8	48	2	9p24
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP3 APPL2	4.06e-04	17	32	2	1291
GeneFamily	V-type ATPases	ATP6V0A1 ATP6V0D1	7.50e-04	23	32	2	415
GeneFamily	Ubiquitin specific peptidases	USP15 USP11	4.40e-03	56	32	2	366
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP3 APPL2 VAV2	5.67e-03	206	32	3	682
Coexpression	GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_UP	APPL2 ADGRL2 TRPM7 NLRC4 INPP4B MX2	7.14e-07	172	48	6	M2945
Coexpression	DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN	PKHD1 MGAT1 ATP6V0D1 ANKEF1 CA3	2.28e-05	186	48	5	M1140
Coexpression	DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN	PKHD1 MGAT1 ATP6V0D1 ANKEF1 CA3	3.30e-05	201	48	5	MM502
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK2 DDX60L ARID4B USP15 PCM1 MX2	7.52e-08	200	48	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	DDX60L ARID4B USP15 HLA-DRB5 MX2	2.03e-06	193	48	5	7256a5a491536c525b31ae96d47ab5c6303cb73a
ToppCell	Mild/Remission\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DDX60L ARID4B USP15 HLA-DRB5 MX2	2.19e-06	196	48	5	71603a3b7df40eb3f267345f55e44a812fea7926
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	DDX60L ARID4B USP15 HLA-DRB5 MX2	2.25e-06	197	48	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	DDX60L ARID4B USP15 HLA-DRB5 MX2	2.30e-06	198	48	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DDX60L ARID4B USP15 HLA-DRB5 MX2	2.30e-06	198	48	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	BAL-Mild-cDC_1\|Mild / Compartment, Disease Groups and Clusters	JAK2 MGAT1 DDX60L USP15 MX2	2.36e-06	199	48	5	c55181bdec8952b54198f0d4c9c5c84265b16572
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	JAK2 ACOT4 CLYBL VAV2 TMEM117	2.42e-06	200	48	5	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGO2 GARNL3 VAV2 L1CAM	2.53e-05	158	48	4	91d265e95156f16459924d3e4dd11c180e164eee
ToppCell	Severe-B_activate-7\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DDX60L ARID4B HLA-DRB5 MX2	3.44e-05	171	48	4	61205a4986c2d0a89aea96ed8dec9e952eeb6ff1
ToppCell	NS-critical-d_0-4-Epithelial-FOXN4+\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ASAP3 TOMM40 ANKEF1 CA3	3.52e-05	172	48	4	a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PKHD1 ERMP1 ADGRL2 TRPM7	3.94e-05	177	48	4	c9e8149639551a4c8daa90fcb2b895fdcff2e2ba
ToppCell	facs-Marrow-T-cells-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK2 SLC9A9 INPP4B L1CAM	4.02e-05	178	48	4	41745a589567ca5ea6d06331f4c8da03595b5f5c
ToppCell	facs-Marrow-T-cells-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK2 SLC9A9 INPP4B L1CAM	4.02e-05	178	48	4	eb940dd64c973f68bcaad6069d3bd56383329db5
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic-Neutrophil\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	USP15 NLRC4 MX2 CXCR1	4.39e-05	182	48	4	1932d77491d6d46278f01fd70eb469ef1b356619
ToppCell	cellseq2-Immune-Hematopoietic-Granulocytic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	USP15 NLRC4 MX2 CXCR1	4.48e-05	183	48	4	cfbf8539104cef9ca830ad4f6bb278746f7078f7
ToppCell	cellseq2-Immune-Hematopoietic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	USP15 NLRC4 MX2 CXCR1	4.48e-05	183	48	4	324ec4374b552da7ce03809945b3a0798342d4ba
ToppCell	wk_15-18-Hematologic-Myeloid-Basophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MTTP CCPG1 USP15 CXCR1	4.98e-05	188	48	4	3638d85452de15a060146628fbbad9d2a36feb13
ToppCell	Severe-B_activate-7\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	DDX60L ARID4B HLA-DRB5 MX2	5.18e-05	190	48	4	67e6c8a5a8724bdf2861fd76a711319dfc71d47a
ToppCell	CV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	DDX60L INPP4B HLA-DRB5 MX2	5.40e-05	192	48	4	2a2052b44e8f679ef484f03ba4fb37b0ec841b88
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ARID4B USP15 PCM1 INPP4B	5.40e-05	192	48	4	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	COL6A5 VAV2 INPP4B CA3	5.51e-05	193	48	4	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 INPP4B L1CAM TMEM117	5.62e-05	194	48	4	4579b4a44f7c731553a284843c296866027d7c0e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PIEZO1 INPP4B L1CAM TMEM117	5.73e-05	195	48	4	3d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCell	CV-Moderate-1\|Moderate / Virus stimulation, Condition and Cluster	DDX60L USP15 HLA-DRB5 MX2	5.85e-05	196	48	4	b50cfcd87c5b67806450cb8b3c6860ab97f6d3b1
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.2.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MGAT1 ATP6V0A1 USP15 HLA-DRB5	5.85e-05	196	48	4	5fe6534af65d43eeacd4b031310242b4f706008b
ToppCell	CV-Moderate-1\|CV / Virus stimulation, Condition and Cluster	DDX60L USP15 HLA-DRB5 MX2	5.97e-05	197	48	4	e3d00d850b4d191f9592ef993c0eaadfe5710b5f
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|lung / Disease (COVID-19 only), tissue and cell type	DDX60L USP15 NLRC4 MX2	5.97e-05	197	48	4	a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCell	Transverse-T_cell-Treg\|T_cell / Region, Cell class and subclass	PKHD1 SLC9A9 ATP6V0A1 HLA-DRB5	5.97e-05	197	48	4	b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCell	COVID-19-lung-Macrophage_VCANhi_FCN1hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DDX60L USP15 NLRC4 MX2	6.08e-05	198	48	4	ea34096bee852a7e996f097fa279381afa8f86ff
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	MGAT1 ATP6V0D1 NLRC4 HLA-DRB5	6.08e-05	198	48	4	ab70bf89690410221ec7aa3149bb50ac34433f99
ToppCell	moderate-Myeloid-Neutrophil\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DDX60L USP15 MX2 CXCR1	6.08e-05	198	48	4	a6306dac34af5783f3a734ef1eaa7a0c03267b4f
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	DDX60L USP15 HLA-DRB5 MX2	6.08e-05	198	48	4	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	severe\|World / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	JAK2 DDX60L MX2 CXCR1	6.20e-05	199	48	4	c24aacef7405700bc5d0b736a38feea12b7f17c8
ToppCell	Caecum-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	SLC9A9 PCM1 INPP4B MX2	6.20e-05	199	48	4	13173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCell	mild-CD163+_Monocytes_(Sample_ID1_d7)\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK2 DDX60L HLA-DRB5 MX2	6.33e-05	200	48	4	82126e25bfd8fba78dc1348fa5ad6a576289a139
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	ARID4B USP15 HLA-DRB5 MX2	6.33e-05	200	48	4	62c25042086f1afd1102e0720e933c2e476468fd
Disease	MASA syndrome (implicated_via_orthology)	TRPM7 L1CAM	5.41e-05	7	48	2	DOID:0060246 (implicated_via_orthology)
Disease	ubiquitin carboxyl-terminal hydrolase 25 measurement	TNXB HLA-DRB5	5.86e-04	22	48	2	EFO_0021881
Disease	Ovarian Serous Adenocarcinoma	JAK2 TRPM7	6.41e-04	23	48	2	C1335177
Disease	Ciliopathies	PKHD1 TMEM138 TSC2	7.72e-04	110	48	3	C4277690
Disease	large artery stroke	TEAD1 CLYBL MX2	8.34e-04	113	48	3	EFO_0005524
Disease	basophil count	JAK2 COL6A5 TNXB HLA-DRB5 CXCR1	1.10e-03	483	48	5	EFO_0005090
Disease	Acute Myeloid Leukemia, M1	JAK2 TSC2 INPP4B	1.12e-03	125	48	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	JAK2 TSC2 INPP4B	1.12e-03	125	48	3	C1879321
Disease	posterior cortical atrophy, Alzheimer disease	TOMM40 LRRIQ3	1.25e-03	32	48	2	MONDO_0004975, MONDO_0018899
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	MTTP TOMM40 ATP6V0D1 HLA-DRB5	1.56e-03	307	48	4	EFO_0004612, EFO_0020946

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLKIGHENGEFQIFL	CA3	146	P07451
FKLFRLVHKLGGFDN	ARID4B	341	Q4LE39
KQGPDFLQSLIKFFH	ASAP3	206	Q8TDY4
QGVFIFIFHCALQKK	ADGRL2	1076	O95490
AAHFAAKGGFFDILK	ANKEF1	221	Q9NU02
FKQHGAQGKFIAFYL	ERMP1	571	Q7Z2K6
FKEHQQLGKGAFTFQ	CLYBL	301	Q8N0X4
FGFVQFKNLLEAGKA	RBM28	156	Q9NW13
ERHLKFLQQLGKGNF	JAK2	846	O60674
LFIYFKNQKGHSGLH	HLA-DRB5	246	Q30154
ILGAFFGKNPLKNFQ	NLRC4	926	Q9NPP4
HGQFFDQHLKFIKLN	MGAT1	321	P26572
INNFIFHKVLGKGSF	PRKCD	346	Q05655
AHFQGFKNGGLRKLL	INPP4B	371	O15327
FVNFLKRGLFHNLCK	DDX60L	1436	Q5H9U9
FVKFFHKQLGSILQD	PCM1	1641	Q15154
HNFGLNFLQTIKGKI	MTTP	236	P55157
GQCNFRFHILFKALG	L1CAM	1041	P32004
INKFFLNGVFIHDQK	CCPG1	681	Q9ULG6
VVDFIQKHGNFKGFI	CPA4	291	Q9UI42
HLKKNFQFIGGSLQI	COL6A5	96	A8TX70
AFIGQNFRHGFLKIL	CXCR1	306	P25024
IGFAHGQINFFKKGA	APPL2	201	Q8NEU8
FKQFAGKHVLFVNVA	GPX6	56	P59796
VNFKFGVLFAKDGQL	GARNL3	201	Q5VVW2
GHELFKLAQIFFNGF	SMYD4	741	Q8IYR2
AGYSLKKRHFFQNLG	SLC9A9	146	Q8IVB4
GLQFHFQVFKTHKKG	SETMAR	136	Q53H47
DVVHGLKKGNFFFKT	SGO2	636	Q562F6
LKGVQFQVLGQAFHK	PKHD1	2201	P08F94
QILAFFCKHLGGTQK	ACOT4	401	Q8N9L9
FQAGLVNLLFHKFKG	TMEM138	66	Q9NPI0
KNFFDFLLTFKQIHG	VPS35L	356	Q7Z3J2
YKFLLFGLQNGKRHG	TNXB	3326	P22105
GHKKRLFTFQFNNLG	USP15	706	Q9Y4E8
LGAFLNHRKNKFQCG	TOMM40	341	O96008
HKSVFIIFFQGDQLK	ATP6V0A1	216	Q93050
IAGKFLFHQRLFGQL	TMEM117	81	Q9H0C3
KDFLAKLGFLHQQAA	ZNF154	96	Q13106
GNFLTKKYNHLNLFL	PIEZO1	2091	Q92508
KKYNHLNLFLFQGFR	PIEZO1	2096	Q92508
LIHLQGKQGFQFFCK	VAV2	481	P52735
LFGKGPQNAFFLVKF	TEAD1	276	P28347
VFKNKVGHFASQFLG	USP11	381	P51784
KKTFNFGQNEALHLF	TRPM7	351	Q96QT4
DFKLGTIKGQFNFVH	TSC2	1656	P49815
LNKLAFLNQFHFGVF	ATP6V0D1	301	P61421
GQKDFVFVKFNGLHL	LRRIQ3	26	A6PVS8
FINVAKKHFGEFFNL	MX2	531	P20592