Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE1A PDE1C PDE4A PDE4B

1.49e-05221394GO:0004115
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE1A PDE1C PDE4A PDE4B

2.14e-05241394GO:0047555
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

PDE1A PDE1C PDE4A PDE4B

2.54e-05251394GO:0004114
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

PDE1A PDE1C PDE4A PDE4B

3.48e-05271394GO:0004112
GeneOntologyMolecularFunctioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity

PDE1A PDE1C

1.44e-0431392GO:0048101
GeneOntologyMolecularFunctioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity

PDE1A PDE1C

1.44e-0431392GO:0004117
GeneOntologyMolecularFunctioncAMP binding

PDE1C PDE4A PDE4B

6.79e-04251393GO:0030552
GeneOntologyMolecularFunction4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity

FUT4 FUT7

7.09e-0461392GO:0017083
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

TEAD2 ZNF527 ZNF658 ZNF629 SREBF2 ZNF213 ADNP ZNF658B RAX2 ZNF768 ZNF354C ZNF587B ZNF2 CSRNP3 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF426

7.65e-04141213921GO:0000981
GeneOntologyCellularComponentprotein phosphatase type 2A complex

PPP2R2D PPP2R2B PPP2R2C

2.09e-04181373GO:0000159
GeneOntologyCellularComponentGATOR1 complex

SZT2 DEPDC5

4.21e-0451372GO:1990130
GeneOntologyCellularComponentphosphatase complex

PPP2R2D PPP4R4 PPP2R2B PPP2R2C

4.65e-04551374GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP2R2D PPP4R4 PPP2R2B PPP2R2C

4.65e-04551374GO:0008287
DomainZnf_C2H2/integrase_DNA-bd

RAG1 ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

6.84e-0769413619IPR013087
DomainPP2A_PR55_CS

PPP2R2D PPP2R2B PPP2R2C

1.50e-0641363IPR018067
DomainPP2A_PR55

PPP2R2D PPP2R2B PPP2R2C

1.50e-0641363IPR000009
DomainPR55_2

PPP2R2D PPP2R2B PPP2R2C

1.50e-0641363PS01025
DomainPR55_1

PPP2R2D PPP2R2B PPP2R2C

1.50e-0641363PS01024
Domain-

RAG1 ZNF527 ZNF658 ZNF629 ZNF213 ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

2.18e-06679136183.30.160.60
Domainzf-C2H2

ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

2.90e-0669313618PF00096
DomainZnf_C2H2-like

RAG1 ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

5.12e-0679613619IPR015880
DomainZnF_C2H2

RAG1 ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

6.34e-0680813619SM00355
DomainPDEase

PDE1A PDE1C PDE4A PDE4B

9.58e-06191364IPR023088
DomainKRAB

ZNF527 ZNF658 ZNF213 ZNF354C ZNF587B ZNF2 ZNF814 ZNF552 ZNF799 ZNF160 ZNF564 ZNF426

1.23e-0535813612PS50805
DomainKRAB

ZNF527 ZNF658 ZNF213 ZNF354C ZNF587B ZNF2 ZNF814 ZNF552 ZNF799 ZNF160 ZNF564 ZNF426

1.23e-0535813612PF01352
DomainZINC_FINGER_C2H2_2

ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

1.34e-0577513618PS50157
DomainZINC_FINGER_C2H2_1

ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

1.39e-0577713618PS00028
DomainPDEase_I

PDE1A PDE1C PDE4A PDE4B

1.46e-05211364PF00233
DomainPDEASE_I

PDE1A PDE1C PDE4A PDE4B

1.46e-05211364PS00126
DomainPDEase_CS

PDE1A PDE1C PDE4A PDE4B

1.46e-05211364IPR023174
DomainKRAB

ZNF527 ZNF658 ZNF213 ZNF354C ZNF587B ZNF2 ZNF814 ZNF552 ZNF799 ZNF160 ZNF564 ZNF426

1.67e-0536913612SM00349
DomainKRAB

ZNF527 ZNF658 ZNF213 ZNF354C ZNF587B ZNF2 ZNF814 ZNF552 ZNF799 ZNF160 ZNF564 ZNF426

1.71e-0537013612IPR001909
Domain-

PDE1A PDE1C PDE4A PDE4B

1.78e-052213641.10.1300.10
DomainPDEase_catalytic_dom

PDE1A PDE1C PDE4A PDE4B

2.14e-05231364IPR002073
DomainZnf_C2H2

ZNF527 ZNF658 ZNF629 ZNF213 ADNP ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

2.23e-0580513618IPR007087
DomainHD/PDEase_dom

PDE1A PDE1C PDE4A PDE4B

2.55e-05241364IPR003607
DomainHDc

PDE1A PDE1C PDE4A PDE4B

2.55e-05241364SM00471
DomainWee1-like_protein_kinase

WEE1 WEE2

5.26e-0521362IPR017164
Domain-

COL11A1 ADGRG6 CELSR3 CSPG4 WDFY3 ADGRD1

6.82e-059513662.60.120.200
DomainPDEase_N

PDE1A PDE1C

1.57e-0431362IPR013706
DomainPDEase_I_N

PDE1A PDE1C

1.57e-0431362PF08499
Domainzf-C2H2_6

ZNF527 ZNF658 ZNF354C ZNF814 ZNF799 ZBTB11 ZNF160 ZNF564 ZNF426

4.95e-043141369PF13912
DomainDUF3398

DOCK11 DOCK9

7.75e-0461362PF11878
DomainDOCK_C/D_N

DOCK11 DOCK9

7.75e-0461362IPR021816
DomainWD40

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

7.84e-042681368SM00320
DomainWD40_repeat

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

8.63e-042721368IPR001680
DomainWD_REPEATS_1

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

9.93e-042781368PS00678
DomainWD_REPEATS_2

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

1.02e-032791368PS50082
DomainWD_REPEATS_REGION

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

1.02e-032791368PS50294
DomainAH/BAR-dom

ARHGEF38 ASAP1 ASAP2

1.33e-03301363IPR027267
Domain-

ARHGEF38 ASAP1 ASAP2

1.33e-033013631.20.1270.60
DomainGlyco_transf_10

FUT4 FUT7

1.43e-0381362PF00852
DomainGlyco_tran_10_N

FUT4 FUT7

1.43e-0381362PF17039
DomainGlyco_tran_10_N

FUT4 FUT7

1.43e-0381362IPR031481
DomainGlyco_trans_10

FUT4 FUT7

1.43e-0381362IPR001503
DomainWD40_repeat_dom

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

1.51e-032971368IPR017986
DomainBEACH

WDR81 WDFY3

1.83e-0391362PS50197
DomainBeach

WDR81 WDFY3

1.83e-0391362PF02138
Domain-

WDR81 WDFY3

1.83e-03913621.10.1540.10
DomainBeach

WDR81 WDFY3

1.83e-0391362SM01026
DomainBEACH_dom

WDR81 WDFY3

1.83e-0391362IPR000409
DomainGPS

ADGRG6 CELSR3 ADGRD1

1.92e-03341363SM00303
DomainGPCR_2_secretin-like_CS

ADGRG6 CELSR3 ADGRD1

1.92e-03341363IPR017983
DomainGPS

ADGRG6 CELSR3 ADGRD1

2.08e-03351363PF01825
DomainGPS

ADGRG6 CELSR3 ADGRD1

2.26e-03361363PS50221
DomainGPS

ADGRG6 CELSR3 ADGRD1

2.45e-03371363IPR000203
DomainBTB

CCIN RHOBTB1 ZBTB11 ZBTB18 KLHL18

2.72e-031311365PF00651
DomainDHR-1_domain

DOCK11 DOCK9

2.77e-03111362IPR027007
DomainDHR_2

DOCK11 DOCK9

2.77e-03111362PS51651
DomainDHR_1

DOCK11 DOCK9

2.77e-03111362PS51650
DomainDHR-2

DOCK11 DOCK9

2.77e-03111362PF06920
DomainDOCK

DOCK11 DOCK9

2.77e-03111362IPR026791
DomainDOCK_C

DOCK11 DOCK9

2.77e-03111362IPR010703
DomainDOCK-C2

DOCK11 DOCK9

2.77e-03111362PF14429
DomainDHR-2

DOCK11 DOCK9

2.77e-03111362IPR027357
DomainWD40

PPP2R2D CORO2A WDR81 PPP2R2B PPP2R2C WDFY3 WDR49

2.91e-032591367PF00400
DomainGPCR_2_extracellular_dom

ADGRG6 CELSR3 ADGRD1

3.06e-03401363IPR001879
DomainG_PROTEIN_RECEP_F2_1

ADGRG6 CELSR3 ADGRD1

3.06e-03401363PS00649
DomainLaminin_G_2

COL11A1 CELSR3 CSPG4

3.06e-03401363PF02210
DomainG_PROTEIN_RECEP_F2_3

ADGRG6 CELSR3 ADGRD1

3.06e-03401363PS50227
Domain-

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

3.07e-0333313682.130.10.10
DomainWD40/YVTN_repeat-like_dom

PPP2R2D CORO2A WDR81 NOL10 PPP2R2B PPP2R2C WDFY3 WDR49

3.18e-033351368IPR015943
DomainLamG

COL11A1 CELSR3 CSPG4

4.02e-03441363SM00282
DomainPH_dom-like

DOCK11 DOCK9 OBSCN ASAP1 ASAP2 TBC1D4 RANBP3L OSBPL5 WDFY3

4.03e-034261369IPR011993
DomainConA-like_dom

COL11A1 ADGRG6 CELSR3 CSPG4 WDFY3 ADGRD1

5.40e-032191366IPR013320
Domain7tm_2

ADGRG6 CELSR3 ADGRD1

5.77e-03501363PF00002
DomainG_PROTEIN_RECEP_F2_2

ADGRG6 CELSR3 ADGRD1

5.77e-03501363PS00650
DomainBTB

CCIN RHOBTB1 ZBTB11 ZBTB18 KLHL18

6.35e-031601365PS50097
DomainPH

DOCK11 DOCK9 OBSCN ASAP1 ASAP2 OSBPL5

6.67e-032291366PF00169
Pubmed

Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes.

PDE1A PDE1C PDE4A PDE4B

2.44e-0714140425852085
Pubmed

Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.

RAG1 FUT4 FUT7

2.55e-074140322461691
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

UBR1 NCAPD3 AARS1 ZNF629 SREBF2 ERGIC2 SIK3 COLGALT1 ZXDB PYGB YY1AP1 TNFAIP2 UQCRC2 ZBTB11

4.14e-076501401438777146
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TEAD2 PDE4A SZT2 DOCK9 OBSCN INO80 REV3L MDN1 CELSR3 CSPG4 OSBPL5 NAV2 PYGB DEPDC5 TNFAIP2 WDFY3 ENDOG ZNF426

5.25e-0711051401835748872
Pubmed

HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PPP2R2D PPP2R2B PPP2R2C

2.21e-067140325816751
Pubmed

Overview of PDEs and their regulation.

PDE1A PDE1C PDE4A PDE4B

2.98e-0625140417307970
Pubmed

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.

PPP2R2D PPP2R2B PPP2R2C

5.27e-069140319762425
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

NCAPD3 PPP2R2D SZT2 SPG11 INO80 SIK3 ADNP CELSR3 OSBPL5 NAV2 DEPDC5

1.06e-055291401114621295
Pubmed

Brain-derived neurotrophic factor signaling does not stimulate subventricular zone neurogenesis in adult mice and rats.

NTRK2 TMEM163

1.61e-052140219074010
Pubmed

Lack of functional selectin-ligand interactions enhances innate immune resistance to systemic Listeria monocytogenes infection.

FUT4 FUT7

1.61e-052140229345354
Pubmed

The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis.

FUT4 FUT7

1.61e-05214028752218
Pubmed

Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis.

FUT4 FUT7

1.61e-052140231104223
Pubmed

The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.

FUT4 FUT7

1.61e-052140211485743
Pubmed

Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart.

FUT4 FUT7

1.61e-052140216709814
Pubmed

Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons.

PDE1C PDE4A

1.61e-052140219305400
Pubmed

Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice.

FUT4 FUT7

1.61e-052140220937846
Pubmed

Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells.

COL11A1 CELSR3

1.61e-052140220416094
Pubmed

Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.

FUT4 FUT7

1.61e-052140216394002
Pubmed

Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin.

FUT4 FUT7

1.61e-052140216127157
Pubmed

Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes.

FUT4 FUT7

1.61e-052140211535629
Pubmed

Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.

PDE1A PDE1C

1.61e-052140211369604
Pubmed

Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.

FUT4 FUT7

1.61e-052140219608009
Pubmed

Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells.

FUT4 FUT7

1.61e-052140222359671
Pubmed

Phosphodiesterase 4B is essential for T(H)2-cell function and development of airway hyperresponsiveness in allergic asthma.

PDE4A PDE4B

1.61e-052140221047676
Pubmed

α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.

FUT4 FUT7

1.61e-052140223562273
Pubmed

Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis.

CACNA1S CACNB2

1.61e-052140226486172
Pubmed

Association between COL11A1 (rs1337185) and ADAMTS5 (rs162509) gene polymorphisms and lumbar spine pathologies in Chinese Han population: an observational study.

COL11A1 ADAMTS5

1.61e-052140228583914
Pubmed

Clinically approved immunomodulators ameliorate behavioral changes in a mouse model of hereditary spastic paraplegia type 11.

RAG1 SPG11

1.61e-052140238435059
Pubmed

Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII.

FUT4 FUT7

1.61e-052140215579466
Pubmed

Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse.

PDE4A PDE4B

1.61e-052140211267656
Pubmed

Fucosyltransferase Induction during Influenza Virus Infection Is Required for the Generation of Functional Memory CD4+ T Cells.

FUT4 FUT7

1.61e-052140229491007
Pubmed

Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury.

FUT4 FUT7

1.61e-052140212193737
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

NRIP1 AARS1 COL6A6 DOCK11 DOCK9 OBSCN SPG11 MDN1 NAV2 RBM46

3.55e-054971401036774506
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CACNB2 PDE4A PDE4B DOCK11 NTRK2 WDR81 GRIK3 SIK3 ADNP DNAJC6 MDN1 DCHS1 WDFY3 FSCN1

3.66e-059631401428671696
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

APPBP2 CCDC73 DOCK11 TAS1R3 IARS1 OBSCN REV3L TBC1D4 MDN1 RANBP3L LTA4H ZBTB11

4.56e-057361401229676528
Pubmed

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation.

TMEM163 UPP1

4.81e-053140223355744
Pubmed

Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum.

FUT4 FUT7

4.81e-053140212869507
Pubmed

Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression.

PDE4A PDE4B

4.81e-053140228356347
Pubmed

A role for leukocyte-endothelial adhesion mechanisms in epilepsy.

FUT4 FUT7

4.81e-053140219029985
Pubmed

Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.

FUT4 FUT7

4.81e-053140215843584
Pubmed

Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase.

PDE1A PDE1C

4.81e-05314029003415
Pubmed

The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).

PDE4A PDE4B

4.81e-053140224555506
Pubmed

Genetic Ablation of Type III Adenylyl Cyclase Exerts Region-Specific Effects on Cilia Architecture in the Mouse Nose.

PDE1C PDE4A

4.81e-053140226942602
Pubmed

Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.

PDE1A PDE1C

4.81e-053140218335582
Pubmed

Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons.

PDE1A PDE1C

4.81e-05314027568196
Pubmed

Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.

PDE4A PDE4B

4.81e-053140217404263
Pubmed

Circ-SPG11 knockdown hampers IL-1β-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5.

SPG11 ADAMTS5

4.81e-053140234140036
Pubmed

Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.

FUT4 FUT7

4.81e-053140215308551
Pubmed

Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.

PDE4A PDE4B

4.81e-053140211114167
Pubmed

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.

PDE4A PDE4B

4.81e-053140216034090
Pubmed

Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance.

FUT4 FUT7

4.81e-053140232341362
Pubmed

Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.

PDE1A PDE1C

4.81e-053140217726023
Pubmed

Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity.

FUT4 FUT7

4.81e-053140222388819
Pubmed

Silencing α1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion.

FUT4 FUT7

4.81e-053140223192350
Pubmed

Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

CUBN RAB38

4.81e-053140226631737
Pubmed

Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.

ADGRG6 TMEM163

4.81e-053140224227709
Pubmed

Roles of the DOCK-D family proteins in a mouse model of neuroinflammation.

DOCK11 DOCK9

4.81e-053140232241915
Pubmed

Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.

PDE4A PDE4B

4.81e-053140215585880
Pubmed

Naïve T cells re-distribute to the lungs of selectin ligand deficient mice.

FUT4 FUT7

4.81e-053140220532047
Pubmed

Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.

PDE4A PDE4B

4.81e-053140210213096
Pubmed

Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment.

FUT4 FUT7

4.81e-053140216352740
Pubmed

T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.

FUT4 FUT7

4.81e-053140216338500
Pubmed

Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.

PDE4A PDE4B

4.81e-053140218508768
Pubmed

Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH.

FUT4 FUT7

4.81e-053140221982762
Pubmed

Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.

FUT4 FUT7

4.81e-053140224322980
Pubmed

Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits.

PPP2R2B PPP2R2C

4.81e-05314029514514
Pubmed

CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV.

FUT4 FUT7

4.81e-053140211278338
Pubmed

α(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation.

FUT4 FUT7

4.81e-053140223657464
Pubmed

Mass Spectrometric Analysis Identifies AIMP1 and LTA4H as FSCN1-Binding Proteins in Laryngeal Squamous Cell Carcinoma.

LTA4H FSCN1

4.81e-053140231287215
Pubmed

Ppp2r2a Knockout Mice Reveal That Protein Phosphatase 2A Regulatory Subunit, PP2A-B55α, Is an Essential Regulator of Neuronal and Epidermal Embryonic Development.

PPP2R2D PPP2R2B PPP2R2C

5.90e-0519140332582689
Pubmed

An integrated workflow for charting the human interaction proteome: insights into the PP2A system.

PPP2R2D WDR81 PPP4R4 PPP2R2B PPP2R2C

6.88e-05105140519156129
Pubmed

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

PDE4A PDE4B

9.60e-05414029371714
Pubmed

Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation.

RAG1 TMEM163

9.60e-054140232644214
Pubmed

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.

PDE4A PDE4B

9.60e-054140234943270
Pubmed

Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms.

FUT4 FUT7

9.60e-054140215059933
Pubmed

Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes.

WEE1 WEE2

9.60e-054140221454751
Pubmed

Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.

FUT4 FUT7

9.60e-054140218755847
Pubmed

Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.

PDE4A PDE4B

9.60e-054140221670503
Pubmed

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.

PDE4A PDE4B

9.60e-054140232738081
Pubmed

Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice.

FUT4 FUT7

9.60e-054140222194593
Pubmed

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.

PDE4A PDE4B

9.60e-05414028413254
Pubmed

Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.

PDE4A PDE4B

9.60e-054140215644445
Pubmed

Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels.

FUT4 FUT7

9.60e-054140210894166
Pubmed

Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration.

ASAP1 ASAP2

9.60e-054140212149250
Pubmed

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.

PDE4A PDE4B

9.60e-054140222946044
Pubmed

Notch-dependent control of myelopoiesis is regulated by fucosylation.

FUT4 FUT7

9.60e-054140218359890
Pubmed

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.

PDE4A PDE4B

9.60e-054140233609559
Pubmed

Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis.

FUT4 FUT7

9.60e-054140218056398
Pubmed

Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade.

FUT4 FUT7

9.60e-054140227488527
Pubmed

The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations.

FUT4 FUT7

9.60e-054140223986452
Pubmed

Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.

PDE4A PDE4B

9.60e-054140224732776
Pubmed

Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.

PDE4A PDE4B

9.60e-054140223008439
Pubmed

A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.

FUT4 FUT7

9.60e-054140237735247
Pubmed

Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.

PDE4A PDE4B

9.60e-054140211839681
Pubmed

Trkb signaling in pericytes is required for cardiac microvessel stabilization.

NTRK2 CSPG4

9.60e-054140224498100
Pubmed

Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.

ZNF587B ZNF552 ZNF799 ZBTB11 ZNF160 ZNF564

9.64e-05181140637372979
Pubmed

Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.

RAG1 NTRK2 ZNF814 ZNF426

1.10e-046114048662221
Pubmed

The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85.

WDR81 PPP2R2C CLEC17A

1.21e-0424140321822214
Pubmed

HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25.

WEE1 PPP2R2B PPP2R2C

1.55e-0426140311531413
Pubmed

Normal embryonic and germ cell development in mice lacking alpha 1,3-fucosyltransferase IX (Fut9) which show disappearance of stage-specific embryonic antigen 1.

MDN1 FUT4

1.60e-045140215121843
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF527 ZNF658 ZNF629 ZNF213 ZNF768 ZNF354C ZNF587B ZXDB ZNF2 ZNF814 ZNF552 ZNF799 ZBTB11 ZNF160 ZBTB18 ZNF564 ZNF426

2.08e-07718961728
GeneFamilyPhosphodiesterases

PDE1A PDE1C PDE4A PDE4B

7.31e-0624964681
GeneFamilyWD repeat domain containing|Protein phosphatase 2 regulatory subunits

PPP2R2D PPP2R2B PPP2R2C

6.30e-0515963696
GeneFamilyWD repeat domain containing

PPP2R2D CORO2A WDR81 PPP2R2B PPP2R2C WDFY3 WDR49

4.93e-04262967362
GeneFamilyBasic leucine zipper proteins|BTB domain containing

CCIN RHOBTB1 ZBTB11 ZBTB18 KLHL18

7.39e-04134965861
GeneFamilyWD repeat domain containing|BEACH domain containing

WDR81 WDFY3

9.80e-0499621230
GeneFamilyFucosyltransferases|Blood group antigens

FUT4 FUT7

2.09e-0313962434
GeneFamilyDNA helicases

INO80 DDX11

3.60e-03179621167
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP1 ASAP2

3.60e-03179621291
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

DOCK11 DOCK9 ASAP1 ASAP2 OSBPL5

4.84e-03206965682
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_1000

GPR12 COL11A1 PDE4B ANG DOCK11 ADAMTS5 CSRNP3 CSPG4 RBM46 FUT4 ADGRD1

4.17e-0723413911gudmap_developingKidney_e15.5_Peripheral blastema_1000_k2
CoexpressionAtlasDevelopingKidney_e15.5_Peripheral blastema_emap-27731_k-means-cluster#2_top-relative-expression-ranked_500

GPR12 COL11A1 PDE4B DOCK11 ADAMTS5 CSRNP3 RBM46 FUT4 ADGRD1

8.82e-062061399gudmap_developingKidney_e15.5_Peripheral blastema_500_k2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 PDE1A NTRK2 ARHGEF38 SLC12A8 TBC1D4 RANBP3L NAV2

1.49e-0718814082ee64bc73a2251fd9f374be759b442cf4ed0d19e
ToppCellCOVID-19-kidney-TAL|kidney / Disease (COVID-19 only), tissue and cell type

PDE1A NTRK2 ARHGEF38 TBC1D4 RANBP3L NAV2 PYGB UPP1

2.05e-07196140804f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCelldroplet-Fat-Gat-18m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRIP1 NCAPD3 ZNF629 DDX11 RHOBTB1 DCHS1 RAD54L

1.61e-06179140708cf9986804a6417a9afb19b50c69a3554f71ec6
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4|TCGA-Pancreas / Sample_Type by Project: Shred V9

PDE1A DOCK11 NTRK2 REV3L ZNF354C ARSB CSRNP3

1.94e-06184140767164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

PDE1A NTRK2 ARHGEF38 TBC1D4 RANBP3L NAV2 PYGB

2.16e-0618714072ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 PDE1A NTRK2 ARHGEF38 TBC1D4 RANBP3L NAV2

2.16e-0618714077ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

AARS1 IARS1 DOCK9 ARHGEF38 INO80 PPP4R4 TMEM163

2.24e-061881407ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CACNB2 PDE1A NTRK2 ARHGEF38 TBC1D4 RANBP3L NAV2

2.24e-0618814073cee9916399e2e7580cecbcbb27424a71e7e7ac0
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Hpse_Sema3c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

COL11A1 COL6A6 DOCK11 GRIK3 LCT INSL6

2.45e-061221406eae9d94f8510ac0f434942451d55c7260977b178
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A WEE1 NTRK2 ARHGEF38 SLC12A8 NAV2 PYGB

2.48e-0619114075a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A WEE1 NTRK2 ARHGEF38 SLC12A8 NAV2 PYGB

2.48e-06191140755ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCellTracheal-NucSeq-Stromal-Schwann-Schwann_nonmyelinating|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE1C GRIK3 DNAJC6 CCIN PPP2R2B RASSF4 MGAT4C

3.05e-0619714075c88a97e8e23a5cd61885acbe1ef339ae6a1e35a
ToppCellTracheal-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE1C GRIK3 DNAJC6 CCIN PPP2R2B RASSF4 MGAT4C

3.05e-061971407c1b2a3fbd5f4aeb3555d8c372efc86f1052e7c65
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C DOCK11 PPFIBP2 GRIK3 ADGRG6 PPP2R2B MGAT4C

3.37e-0620014076a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CCL|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TMEM217 DBF4B CD300A CNNM3 UPP1 TNFAIP2 ZNF426

3.37e-06200140707f2f01c95f2da011cf0f266dc1175082c93136e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

PDE1A GPR12 GRIK3 PPP2R2B CSRNP3 UQCRC2 ZBTB18

3.37e-06200140744bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C COL11A1 PDE4B GRIK3 ASAP2 ADGRD1

3.37e-0620014071a3d29a580d1b405a74869a1da3e818c581fc559
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C DOCK11 PPFIBP2 GRIK3 ADGRG6 PPP2R2B MGAT4C

3.37e-0620014078d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E---L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C COL11A1 PDE4B GRIK3 ASAP2 ADGRD1

3.37e-0620014076f9ed8fe9cda91185c3a1a675353e11b8fec6ef1
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C DOCK11 PPFIBP2 GRIK3 ADGRG6 PPP2R2B MGAT4C

3.37e-062001407cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E--|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C COL11A1 PDE4B GRIK3 ASAP2 ADGRD1

3.37e-06200140786705dfc05b3e1576543b93883c88fb55b742855
ToppCellNeuronal-Excitatory-eB(RORB)-SEMA3E|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1A PDE1C COL11A1 PDE4B GRIK3 ASAP2 ADGRD1

3.37e-062001407db194b4f524fd008b3c5b4b6014b436190a1b87a
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN|PND01-03-samps / Age Group, Lineage, Cell class and subclass

COL11A1 ADAMTS5 ZNF2 CSRNP3 ADGRD1 IMPG2

4.79e-061371406a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE1A PLB1 DBF4B ARHGEF38 CUBN CSRNP3

5.00e-061381406611fe0fb284e12678f9c47a0bdbfc367a93c52b3
ToppCellChildren_(3_yrs)-Mesenchymal-chondrocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TEAD2 COL11A1 RANBP3L CSPG4 ENDOG MGAT4C

1.01e-05156140660f1ce38e34b582f589db1e0d6139282c1902b2b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Calb2_Pdlim5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE1C COL11A1 DOCK11 GRIK3 TBC1D4 DCHS1

1.21e-051611406bf70be1de418615b5442ec684552551edaf1f072
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RAG1 WEE1 NTRK2 CELSR3 DCHS1 FUT7

1.34e-051641406d2218d50e0e2d19f919dcb460b3840687c082810
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A PDE1C RHBG PPFIBP2 ADAMTS5 TMEM163

1.44e-0516614066fe8db8d45177a78605681f22e04fa8d0594f2df
ToppCellwk_20-22-Hematologic-Myeloid-GMP|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

DBF4B NOL10 SIK3 CELSR3 FUT4 FUT7

1.44e-051661406d96e88e73a40205f32cebd7e54ca1ff09ee1e7e8
ToppCellASK454-Epithelial-Transformed_epithelium|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

APPBP2 PPP2R2D PPFIBP2 ZNF768 ZNF552 TMEM163

1.76e-0517214063986f0f098ef5e096c8d9ee3d335b8404083701f
ToppCellEndothelial-B-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

PDE1A OVOS2 ADAMTS5 PPP2R2B FSCN1 MGAT4C

1.82e-051731406a81992965137195d20fc498f750975303961a828
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL11A1 COL6A6 PPFIBP2 ADAMTS5 DNAJC6 ADGRD1

1.88e-051741406a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCellfacs-Pancreas-Exocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L TEAD2 PDE4A SLC12A8 RANBP3L ZBTB18

1.94e-0517514063f1b2e23fec953148fb0711e523c463adb07dca4
ToppCelldroplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1S TBC1D4 INSL6 DEPDC5 FSCN1 MAPK11

2.00e-05176140624b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

PDE4A CD300A ARSB ZNF552 DEPDC5 UQCRC2

2.00e-051761406581d78811b2d99f38a2c7cc268aeb1cf932379c2
ToppCellEndothelial-B-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

PDE1A OVOS2 ADAMTS5 DCHS1 FSCN1 MGAT4C

2.00e-051761406b288116a4588a1f9db9d49af92cea118937c9201
ToppCellPCW_05-06-Neuronal-Neuronal_postreplicative-neuro_migrating_neuronal_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

PDE1C GPR12 PDE4B CORO2A GRIK3 ZBTB18

2.13e-05178140638ffbd01230c99f52274424ee6c172381daffc73
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 CUBN ADGRG6 TMEM163 TNFAIP2 RASSF4

2.20e-05179140658ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCellfacs-Pancreas-Exocrine-18m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L TEAD2 PDE4A SLC12A8 RANBP3L ZBTB18

2.20e-051791406bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C COL11A1 GRIK3 ASAP2 ADGRD1

2.20e-051791406b35a7f8115c997c390201da01d7cb10b10769aec
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW23-Mesenchymal-Unfolded_protein_responsible_cell|GW23 / Sample Type, Dataset, Time_group, and Cell type.

MYH14 OSBPL5 ZNF799 FUT4 ENDOG

2.24e-0510714057fee0193ee02e9cc62f506660ea7ec23fb4d0c84
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1C RHBG SIK3 ASAP2 TBC1D4 TMEM163

2.27e-051801406cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 DOCK11 ADGRG6 TMEM163 MGAT4C

2.34e-0518114065f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 DOCK11 ADGRG6 TMEM163 MGAT4C

2.34e-051811406c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CUBN PPP2R2B ARSB RHOBTB1 RASSF4 G6PC1

2.49e-05183140684b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCellMesenchymal_cells-Osteoblasts|Mesenchymal_cells / Lineage and Cell class

PLB1 COL11A1 PPFIBP2 CSRNP3 RANBP3L RASSF4

2.49e-051831406d6b52d52fe9a7a6c798947f05420d79fe12e4662
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-late_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L CACNA1S RHBG CUBN LAX1 INSL6

2.57e-05184140642cadfdb5d29a50bd7e901ddd14d42b39e8474f0
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PDE1A PDE1C COL11A1 GRIK3 ASAP2 ADGRD1

2.57e-0518414069cc5c588f7c6631b3fb8a522214a09ca32947e72
ToppCelldroplet-Spleen-nan-3m-Lymphocytic-plasma_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SEL1L CACNA1S PLB1 RHOBTB1 INSL6 FUT4

2.65e-051851406ff95a45b7cb782961bb8f008b6b507af2d4cb8b7
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLB1 DNAAF9 RHOBTB1 NAV2 TNFAIP2 RASSF4

2.65e-0518514068207f9eff113eed429e961748c6b17d672a13b33
ToppCellMild_COVID-19-Epithelial-AT1/AT2|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

CACNB2 TEAD2 PDE1A PDE1C RANBP3L NAV2

2.65e-051851406c55fdba1e3818ec0404d7ab473bf18dd25f2bb0a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK11 CUBN ADGRG6 RHOBTB1 TNFAIP2 RASSF4

2.73e-051861406f28d72b47624b69a580b4429e2be560a26898591
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 DOCK11 ADGRG6 TMEM163 MGAT4C

2.90e-051881406b21e93a70583c30d05c0833cd3d4d4bca44a039e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 DOCK11 ADGRG6 TMEM163 MGAT4C

2.90e-051881406874404a4fd9aa42873f6c53dc42da22d3b0fdb9e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A WEE1 NTRK2 ARHGEF38 RANBP3L NAV2

3.08e-051901406bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLB1 PDE4B DNAAF9 RHOBTB1 TNFAIP2 RASSF4

3.08e-051901406f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PDE4B PPFIBP2 DNAAF9 ARSB TNFAIP2 RASSF4

3.08e-0519014062d54fca50593fbd11fe13fc2bfaf937a05db776d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A WEE1 NTRK2 ARHGEF38 RANBP3L NAV2

3.08e-051901406b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A NTRK2 ARHGEF38 TBC1D4 RANBP3L NAV2

3.08e-0519014063dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE1A COL11A1 COL6A6 NTRK2 ADAMTS5 ADGRD1

3.17e-0519114064b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PDE1A COL11A1 COL6A6 NTRK2 ADAMTS5 ADGRD1

3.17e-05191140675d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCelldroplet-Heart-nan-18m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C OBSCN TBC1D4 MYH14 PYGB TMEM163

3.26e-0519214060bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCelldroplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE1C OBSCN TBC1D4 MYH14 PYGB TMEM163

3.26e-051921406d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCellfacs-Marrow-KLS-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WEE1 DNAJC6 RAB38 FUT7 MFSD13A RAD54L

3.46e-051941406c9ebdcc2ea600975dade68a41fa65d1f8a5a5926
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A RHBG CORO2A ADGRG6 PPP2R2B MYH14

3.56e-0519514063d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A WEE1 NTRK2 TBC1D4 RANBP3L NAV2

3.66e-0519614061bfc3c85ce9501f52a912e53cbded7de74572b9d
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area|World / Primary Cells by Cluster

PDE1A NTRK2 DOCK9 GRIK3 PPP2R2B CSRNP3

3.76e-05197140679b9e7f2e8e33b3c547f716be5667156c48b0dfc
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Layer_VI_Pan-area-33|World / Primary Cells by Cluster

PDE1A NTRK2 DOCK9 GRIK3 PPP2R2B CSRNP3

3.76e-051971406d20f29088e9afd8a960d6f680075c380e550f8a7
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

PDE4B DOCK11 COLGALT1 ASAP1 UPP1 TNFAIP2

3.87e-0519814069bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANG CUBN ADGRG6 RHOBTB1 TNFAIP2 RASSF4

3.87e-051981406be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 ADGRG6 TMEM163 FSCN1 MGAT4C

3.98e-051991406b9338b739162cd8e5661c9a4dcb41a31219b5723
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1A COL11A1 ADGRG6 TMEM163 FSCN1 MGAT4C

3.98e-051991406c972d3036151403f26fa9d6271520639c281ab84
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C PDE4B DOCK11 PPFIBP2 GRIK3 ADGRG6

4.10e-052001406a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellTracheal-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A1 NTRK2 PPP4R4 ADGRG6 RANBP3L CSPG4

4.10e-052001406b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE4B DOCK11 COLGALT1 UPP1 TNFAIP2 WDR49

4.10e-052001406a443e475e7a10c26a6173d1af961de6219e0e567
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C PDE4B DOCK11 PPFIBP2 GRIK3 ADGRG6

4.10e-05200140633b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCellTracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A1 NTRK2 PPP4R4 ADGRG6 RANBP3L CSPG4

4.10e-052001406f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCellBronchial-NucSeq-Stromal-Chondrocytic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A1 NTRK2 PPP4R4 ADGRG6 RANBP3L CSPG4

4.10e-052001406b7b9441fa7ab0d43741a2ebd5ec1a48d537c6d47
ToppCell5'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE1C GPR12 GRIK3 ADGRG6 FSCN1 RASSF4

4.10e-052001406de55100e98d3e9b8a74e37aebcd3afa2b0996527
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

PDE1C PDE4B DOCK11 PPFIBP2 GRIK3 ADGRG6

4.10e-0520014069719fabddc34051949468a7520289e3c750de4f8
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PDE4B DOCK11 COLGALT1 UPP1 TNFAIP2 WDR49

4.10e-052001406ed785a6d08ca2b350dc3307b587eadfb2886d1f9
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_2|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

PDE1A GPR12 DOCK9 PPP2R2B TMEM163 ZBTB18

4.10e-0520014060cb0755a101ec655359d051d6a8807408d727c55
ToppCellTracheal-10x5prime-Immune_Myeloid-Dendritic_cell|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PDE4B CD300A TLR10 CLEC17A TMEM163 FUT7

4.10e-0520014060cb6e65f9efe1d4fd18b8ef4333cc39956cafdad
ToppCellBronchial-NucSeq-Stromal-Chondrocytic-Chondrocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

COL11A1 NTRK2 PPP4R4 ADGRG6 RANBP3L CSPG4

4.10e-0520014067c673ad0ea503ebd196579684d25d5f9e6a41030
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE1C RHBG ARHGEF38 ADAMTS5 TMEM163

5.90e-051311405d706405453408fbcfcabb1c7702b80f9e649ffca
ToppCellLPS-antiTNF-Epithelial_alveolar-Mes-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRIK3 MDN1 OSBPL5 TMEM163 IMPG2

6.57e-05134140564979e1a056b7406e1be39c5ebe2f8d731ac3c17
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Crhr2_Efemp1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NRIP1 PDE1C GRIK3 DCHS1 MGAT4C

7.05e-051361405e3a2425ba5ef538dbacab1479e682837ae42a888
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-MPP_myeloid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NRIP1 PDE1A GPR12 CUBN TMEM163

8.08e-051401405eb1d22f5f5dbf60b6485464baec4be9b3060f65c
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)|Striatum / BrainAtlas - Mouse McCarroll V32

TAS1R3 ARHGEF38 CUBN FUT7

9.68e-057614043073a8ace46ad18bddd22ec8f3a1b59ee2fd989d
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat-Inhibitory_Neuron.Gad1Gad2-Chat-Slc17a8.Chat_(cholinergic_interneuron)-|Striatum / BrainAtlas - Mouse McCarroll V32

TAS1R3 ARHGEF38 CUBN FUT7

9.68e-057614043f5865b9cb6648b88eb873018e513c5efb457ae5
ToppCellStriatum-Neuronal-Inhibitory-iN2(Gad1Gad2)-Chat|Striatum / BrainAtlas - Mouse McCarroll V32

TAS1R3 ARHGEF38 CUBN FUT7

9.68e-05761404041a8984b3ae4bb03ae6db8234c1333ac73098fa
ToppCell368C-Myeloid-Macrophage-FABP4+_Macrophage|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

PDE1A LAX1 ASAP2 WDFY3 ZNF160

9.85e-0514614055b2608b56204dda9a773988f42ff00a9fa743a39
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PDE1A OBSCN GRIK3 ADAMTS5 MGAT4C

1.15e-041511405f50c5ae9dae507df750df25e151b58685fec70ce
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-pDC_progenitor|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

CCDC73 CUBN TMEM163 MAPK11 WDR49

1.15e-0415114058ffd71d847fe1aeebe7f43c4b6ca73efb19d6041
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE1C SREBF2 TBC1D4 CELSR3 FUT7

1.19e-0415214050fda8980b10ce16179dea92301db74d728f41794
ToppCelldroplet-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHBG ZNF354C RANBP3L SERPINC1 G6PC1

1.19e-041521405c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell356C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SEL1L DBF4B TBC1D4 CELSR3 DNAJB5

1.27e-0415414051f8d127b657976656e4ec292f26d619943533b86
ToppCellPND03-Immune-Immune_Myeloid-DC-maDC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBC1D4 ARSB INSL6 FSCN1 RASSF4

1.34e-041561405095281ea78aefa0ee638191a03f8d6f62a86a9ff
ToppCellPND03-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TBC1D4 ARSB INSL6 FSCN1 RASSF4

1.34e-04156140529b04143f71a0ecc600ac670abd1d521bee55fe7
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma|TCGA-Brain / Sample_Type by Project: Shred V9

NTRK2 DNAAF9 MDN1 RASSF4 MGAT4C

1.56e-041611405347edb0de10850b7d16c40945751033289289c9b
DrugAA-2379

PDE1A PDE1C PDE4A PDE4B

7.56e-06211404CID000128390
DrugHWA 153

PDE1A PDE1C PDE4A PDE4B

9.19e-06221404CID000162797
Druggriseolic acid

PDE1A PDE1C PDE4A PDE4B

1.11e-05231404CID000127607
Drugatherosperminine

PDE1A PDE1C PDE4A PDE4B

1.11e-05231404CID000096918
DrugKF18280

PDE4A PDE4B LTA4H

1.25e-0581403CID003071941
DrugTrichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A

PDE4A ANG RHBG DNAJC6 PPP2R2B DNAJB5 FSCN1 ZBTB18

1.67e-0518114085987_UP
Drugdesethyl KBT-3022

PDE1A PDE1C PDE4A PDE4B

1.84e-05261404CID000127736
DrugT-440

PDE1A PDE1C PDE4A PDE4B

1.84e-05261404CID000177965
DrugRo 15-2041

PDE1A PDE1C PDE4A PDE4B

1.84e-05261404CID000132434
DrugNomifensine maleate [32795-47-4]; Up 200; 11.2uM; PC3; HT_HG-U133A

PDE4B WEE1 DBF4B NTRK2 ADAMTS5 MDN1 MYH14 WDFY3

2.96e-0519614085863_UP
Drugestradiol, USP; Down 200; 0.01uM; PC3; HT_HG-U133A

CACNB2 COL11A1 FKRP NTRK2 ADAMTS5 PPP4R4 MYH14 MFSD13A

2.96e-0519614084465_DN
Drug6-Hydroxytropinone [5932-53-6]; Down 200; 25.8uM; MCF7; HT_HG-U133A

SEL1L SZT2 PPFIBP2 NTRK2 SLC12A8 LAX1 PPP2R2B FSCN1

2.96e-0519614084833_DN
DrugSuprofen [40828-46-4]; Up 200; 15.4uM; HL60; HT_HG-U133A

TMEM53 ANG FKRP NTRK2 SLC12A8 PPP2R2B MYH14 CSPG4

3.18e-0519814083005_UP
DrugCholecalciferol [67-97-0]; Up 200; 10.4uM; MCF7; HT_HG-U133A

PPFIBP2 SREBF2 NOL10 LAX1 ADGRG6 TBC1D4 TNFAIP2 DNAJB5

3.18e-0519814085002_UP
DrugArecoline hydrobromide [300-08-3]; Up 200; 17uM; MCF7; HT_HG-U133A

PDE1C PPFIBP2 DOCK9 MYH14 UPP1 TNFAIP2 WDFY3 IMPG2

3.30e-0519914085423_UP
Drugimidazole-4-carboxamide

PDE1A PDE1C PDE4A PDE4B

4.31e-05321404CID000152917
Drugcaffeine

CACNA1S CACNB2 PDE1A PDE1C PDE4A PDE4B ANG GRIK3 INO80 PYGB TNFAIP2 UQCRC2 MAPK11

4.52e-0556214013CID000002519
Drugdyphylline

PDE1A PDE1C PDE4A PDE4B

4.88e-05331404CID000003182
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

PPP2R2D PPP2R2B PPP2R2C

1.83e-05121313DOID:1441 (implicated_via_orthology)
Diseaselevel of Ceramide (d40:1) in blood serum

SIK3 G6PC1

1.05e-03111312OBA_2045185
Diseasenon-alcoholic fatty liver disease, type 2 diabetes mellitus

PDE1C PLB1 DNAAF9 PPP2R2B

1.49e-031101314EFO_0003095, MONDO_0005148
Diseaseperipheral arterial disease, traffic air pollution measurement

ADGRG6 TLR10 PPP2R2C NAV2 PYGB

1.78e-031941315EFO_0004265, EFO_0007908
Diseaseosteoarthritis (implicated_via_orthology)

COL11A1 ADAMTS5

1.98e-03151312DOID:8398 (implicated_via_orthology)
Diseaseplatelet component distribution width

NRIP1 WEE1 DBF4B DOCK9 ZNF629 CUBN ASAP1 BRD8 PYGB N4BP2L2

2.04e-0375513110EFO_0007984
Diseasephosphatidylcholine 38:6 measurement

CPOX DEPDC5

2.25e-03161312EFO_0010388
DiseaseAmyotrophic lateral sclerosis

ANG SPG11

2.55e-03171312cv:C0002736
DiseaseSARS-CoV-2 antibody measurement, response to COVID-19 vaccine

COL11A1 NTRK2 COLGALT1

2.67e-03621313EFO_0803360, EFO_0803362
Diseasebipolar I disorder

CACNB2 CUBN CNNM3 WDR49

3.66e-031411314EFO_0009963
DiseaseColorectal Carcinoma

CACNB2 OBSCN GRIK3 CUBN RAB38 CSRNP3 DCHS1 UQCRC2 WDR49

4.19e-037021319C0009402
Diseasepulmonary arterial hypertension

PDE1A TMEM217

4.26e-03221312EFO_0001361

Protein segments in the cluster

PeptideGeneStartEntry
AFSQYSFLTEHERIH

ZNF354C

476

Q86Y25
FSAYKSHFRNVHSED

ADNP

86

Q9H2P0
EATPRRVFANAHTYH

PPP2R2B

161

Q00005
RVFANAHTYHINSIS

PPP2R2B

166

Q00005
NHSFLRDHSYVTEAD

PPP2R2C

11

Q9Y2T4
HAHFRRDGTNVLYSA

DNAJB5

251

O75953
NFSSSHDHFRVLALA

CSPG4

2016

Q6UVK1
NHVFFAHRNVLAAVS

CCIN

36

Q13939
ASHQNLLHFLSEVAY

BRD8

941

Q9H0E9
RYHIHANLSFAVLVA

ADGRD1

601

Q6QNK2
SIANRLYSHASIENH

ADAMTS5

296

Q9UNA0
KRNSHTDNVSYEHSF

ADGRG6

1186

Q86SQ4
QIFYAVHAFQARSDH

ARHGEF38

716

Q9NXL2
HLAALVNHESYNFSH

ERGIC2

201

Q96RQ1
IALQHHFLATSHYVT

GPR12

231

P47775
EASPRRIFANAHTYH

PPP2R2D

171

Q66LE6
NIHVATAHEDLAYSS

APPBP2

326

Q92624
ANSRFATTFYQHLAD

SERPINC1

86

P01008
AFAVRTNVSYSAAHE

CACNB2

116

Q08289
FHSITRSHAENLERY

RAG1

746

P15918
TYQLHQLERAFEASH

RAX2

36

Q96IS3
QFTLLHLDYNFHRSS

RBM46

461

Q8TBY0
THVIENLHAAAYRNA

UQCRC2

171

P22695
HQNFSSHYRATIGVD

RAB38

31

P57729
RFSINGHFYNHKTSV

RASSF4

166

Q9H2L5
AASTAITFVFHQRSH

RAD54L

726

Q92698
TAYHELVARHFLSEF

ARHGAP36

66

Q6ZRI8
ENAYHIHQARTRSFD

INO80

456

Q9ULG1
SHDQAVRTYQEHKAS

LTA4H

581

P09960
LAYHEAAGRHSNSRQ

DEPDC5

661

O75140
THQLNSERYVHTFKD

MGAT4C

61

Q9UBM8
HAPAFNQSRYHAVVS

DCHS1

251

Q96JQ0
RVSAAEALAHAYFSQ

MAPK11

296

Q15759
HLEASAASLRNFYSH

MDN1

2556

Q9NU22
RASYGEAQAVLFHHR

FUT4

226

P22083
FDLISHDRTYHFQAE

ASAP2

366

O43150
ALSGRFNSHVHVEYE

ASAP2

676

O43150
TAVHESHAKNASFYA

CSRNP3

416

Q8WYN3
LLTASARQNFTYHCH

COL11A1

1701

P12107
RHLRDQADFSVLHYA

MYH14

586

Q7Z406
LYNDRSVLENHHVSA

PDE1A

281

P54750
YNDRSVLENHHLSAA

PDE1C

291

Q14123
AYHNSLHAADVLQST

PDE4A

431

P27815
SDVAYHNSLHAADVA

PDE4B

401

Q07343
NRSLLASADAVVFHH

FUT7

81

Q11130
NAFQEHTAHIHATEY

LAX1

136

Q8IWV1
YSQRFGLHHVNFSDS

LCT

811

P09848
SSEAHLQQYSREHAL

NRIP1

271

P48552
DNSRYTHFLTQHYDA

ANG

26

P03950
VFLHNDRYIEFHSQS

NOL10

111

Q9BSC4
YLVSLSHDSGNFQHR

OVOS2

476

Q6IE36
YCSRTHSQLAQFVHE

DDX11

231

Q96FC9
VNHHSAASNETYQER

PPFIBP2

96

Q8ND30
RHSVIRSLFYHQAGE

OBSCN

6866

Q5VST9
NTVNYTFLAFDLEHH

CUBN

1316

O60494
LQIFSSVEHYNHHTA

KLHL18

441

O94889
SVFTTNAYAVVSHHN

DOCK11

691

Q5JSL3
NQRFPASYHHAVETV

DOCK9

986

Q9BZ29
YSVQTADHRFLRHDG

FSCN1

186

Q16658
SNSHVFSSVHYEREF

CACNA1S

1676

Q13698
QSAQHRSFALEAHLY

DBF4B

316

Q8NFT6
VAETFSHIHSIYNAS

G6PC1

191

P35575
IDHHVSYAAFSANSK

CCDC73

706

Q6ZRK6
YDSVPITRSVHDNHF

CORO2A

26

Q92828
SFLDSRHLDHYTVYN

DNAJC6

96

O75061
HAAHFQRYLSSALEA

DNAAF9

791

Q5TEA3
AAKLHALRTEYFAQH

HAUS7

226

Q99871
DLISHNRTYHFQAED

ASAP1

386

Q9ULH1
EYSAFNTSVHAAIRH

ARSB

421

P15848
VFTFHNHGRTANLYS

CYB561A3

101

Q8NBI2
ALAHAAFSAAQHRSY

MMGT1

16

Q8N4V1
DFFRVQYSESNHLHV

FKRP

401

Q9H9S5
ANTHRPVFQSAHYSV

CELSR3

851

Q9NYQ7
YDIQRIHFHDSFEAT

GRIK3

81

Q13003
EYKAHFSLRNLHAFS

COLGALT1

536

Q8NBJ5
ADFATRDRYHHSSLV

SLC12A8

691

A0AV02
INYDERSHLHDTFTQ

SPACA6

71

W5XKT8
TYLNQEDAVHFHRTL

CPOX

286

P36551
DLALSAHDRTHLNFY

MFSD13A

151

Q14CX5
AILSYNSHARHLVRF

COL6A6

1801

A6NMZ7
DSRTFYIAEQVSHHP

OSBPL5

466

Q9H0X9
AAHQLYNYVADHASS

SZT2

3106

Q5T011
EDILYHFNLTTSRHN

UPP1

31

Q16831
QDESVSIHAYTHSFL

PPP4R4

121

Q6NUP7
NVRFHAFISYSEHDS

TLR10

631

Q9BXR5
THYRLVANHVASDIS

SEL1L

316

Q9UBV2
FSSSHNINVYIHENA

INSL6

131

Q9Y581
REDDSVHAYHRATNA

ENDOG

116

Q14249
VHAYHRATNADYRGS

ENDOG

121

Q14249
VDNFVSRLHSSLHFS

NAV2

1641

Q8IVL1
ERQALSYQNADSYHH

SIK3

1041

Q9Y2K2
ALQRHHTIQNSDDAY

SIK3

1211

Q9Y2K2
YSVHQNSHTRYHEAV

TEX49

46

A0A1B0GTD5
DAVDSYQRHLFVHIS

TEAD2

241

Q15562
DIVTRYAHQSGFHVD

IARS1

66

P41252
EHIFAHRIYLATSSS

RHOBTB1

276

O94844
ATDDLHHSDRYQTFL

RNF220

291

Q5VTB9
YFFIRTLQAHHDRSE

IMPG2

1121

Q9BZV3
LYSAANFVHHLRNAL

PLB1

871

Q6P1J6
HYASVVFDSNTNRIA

CD300A

266

Q9UGN4
ENNVSHSTLVALFYH

NCAPD3

81

P42695
YSHLVIINSFAEHNF

CLEC17A

286

Q6ZS10
RENTIAGANHTHTFY

C10orf62

186

Q5T681
FDESNRLATHHYLYQ

CNNM3

536

Q8NE01
YLASQHFVHRDLATR

NTRK2

666

Q16620
DQFDHLSSHLYLRNV

SPG11

566

Q96JI7
FNYASSIRIHERTHT

ZNF564

486

Q8TBZ8
YSSSFQRHERAHNGD

ZNF564

516

Q8TBZ8
TVSALFSHNRAHFRE

ZXDB

406

P98169
ESYHQHFAAHLAAVA

TNFAIP2

251

Q03169
VSAGLNHHQTFSVYA

TAS1R3

381

Q7RTX0
AVLGQHSHVVRYFSA

WEE1

351

P30291
FQYSASLRAHLIRHT

ZBTB11

606

O95625
AFSDRSSLTFHQAIH

ZNF160

601

Q9HCG1
AFYGVSSLNRHQKAH

ZNF2

321

Q9BSG1
DNVFSLHEDNHYRIS

WDFY3

991

Q8IZQ1
DFFKRNEHTYVHSSA

AARS1

16

P49588
LTNYTFENVSFHVLH

REV3L

2476

O60673
HRSNHSNADNEFYFR

RHBG

46

Q9H310
SAQDTAYLYAAIHHR

RANBP3L

391

Q86VV4
SFQYSHNLSRHAVVH

ZBTB18

446

Q99592
TSARDAALAYHRLHQ

SREBF2

661

Q12772
FNIAQGIHAFDYHSR

WDR49

16

Q8IV35
HQELGSFHIRASYAA

VPS16

626

Q9H269
ITALFHTHFYDRLQD

TMEM53

191

Q6P2H8
DYFFALAHTVRDHLV

PYGB

51

P11216
FADSSYLLRHQRTHS

ZNF768

326

Q9H5H4
HSYDHVIYSLQRALD

UBR1

236

Q8IWV7
RGKAFSYHNSLQTHE

ZNF799

146

Q96GE5
VATQHADEIYHQTAS

TSTD2

96

Q5T7W7
ISRFIHNSHDLTYFA

TBC1D4

126

O60343
SFTYNSALRAHQRIH

ZNF658

666

Q5TYW1
LGTFAQSSIALHHQY

YY1AP1

206

Q9H869
FSKYVSFSNHQRVHS

ZNF587B

251

E7ETH6
KYDSFSNHQGVHTRE

ZNF552

251

Q9H707
SFSRSAYLADHQRIH

ZNF213

381

O14771
SNENSALHEVYAHAV

WEE2

251

P0C1S8
SHLESQYFERQSFHT

TMEM217

191

Q8N7C4
FYRSSDLIQHQATHT

ZNF629

271

Q9UEG4
NAAAVHSAHREYIAC

TMEM163

141

Q8TC26
AFNYSNSFQIHGRTH

ZNF426

316

Q9BUY5
AHTHLASYGVVQLFD

WDR81

571

Q562E7
FSKYASLSNHQRVHT

ZNF814

251

B7Z6K7
FSKYVSFSNHQRVHT

ZNF814

361

B7Z6K7
SFTYNSALRAHQRIH

ZNF658B

426

Q4V348
AFSRYAFLVEHQRIH

ZNF527

366

Q8NB42
ESYVFHNHSNADFHR

N4BP2L2

31

Q92802