Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nuclear receptor binding	WIPI1 LEF1 MED13 CRX	3.47e-04	187	36	4	GO:0016922
GeneOntologyMolecularFunction	transition metal ion transmembrane transporter activity	SLC31A1 SLC30A6	2.85e-03	44	36	2	GO:0046915
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ONECUT2 NR6A1 FOXA2 LEF1 CRX	3.13e-03	560	36	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ONECUT2 NR6A1 FOXA2 LEF1 CRX	3.28e-03	566	36	5	GO:0001216
GeneOntologyMolecularFunction	nuclear estrogen receptor binding	WIPI1 LEF1	4.11e-03	53	36	2	GO:0030331
GeneOntologyBiologicalProcess	regulation of tetrapyrrole biosynthetic process	TMEM14C TMEM14DP TMEM14B	4.81e-07	9	38	3	GO:1901463
GeneOntologyBiologicalProcess	regulation of heme biosynthetic process	TMEM14C TMEM14DP TMEM14B	4.81e-07	9	38	3	GO:0070453
GeneOntologyBiologicalProcess	regulation of tetrapyrrole metabolic process	TMEM14C TMEM14DP TMEM14B	6.86e-07	10	38	3	GO:1901401
GeneOntologyBiologicalProcess	heme metabolic process	TMEM14C AMBP TMEM14DP TMEM14B	2.90e-06	54	38	4	GO:0042168
GeneOntologyBiologicalProcess	porphyrin-containing compound metabolic process	TMEM14C AMBP TMEM14DP TMEM14B	5.40e-06	63	38	4	GO:0006778
GeneOntologyBiologicalProcess	tetrapyrrole metabolic process	TMEM14C AMBP TMEM14DP TMEM14B	9.73e-06	73	38	4	GO:0033013
GeneOntologyBiologicalProcess	pigment metabolic process	TMEM14C AMBP TMEM14DP TMEM14B	2.65e-05	94	38	4	GO:0042440
GeneOntologyBiologicalProcess	heme biosynthetic process	TMEM14C TMEM14DP TMEM14B	3.32e-05	34	38	3	GO:0006783
GeneOntologyBiologicalProcess	mitochondrial transport	TMEM14C SLC25A20 TMEM14DP SLC1A3 TMEM14B	3.55e-05	205	38	5	GO:0006839
GeneOntologyBiologicalProcess	porphyrin-containing compound biosynthetic process	TMEM14C TMEM14DP TMEM14B	5.04e-05	39	38	3	GO:0006779
GeneOntologyBiologicalProcess	tetrapyrrole biosynthetic process	TMEM14C TMEM14DP TMEM14B	5.04e-05	39	38	3	GO:0033014
GeneOntologyBiologicalProcess	pigment biosynthetic process	TMEM14C TMEM14DP TMEM14B	2.12e-04	63	38	3	GO:0046148
GeneOntologyBiologicalProcess	Golgi to endosome transport	WIPI1 SLC30A6	4.96e-04	18	38	2	GO:0006895
GeneOntologyCellularComponent	organelle inner membrane	TMEM14C AMBP SLC25A20 TMEM14DP DPY19L2 SLC1A3 TMEM14B	1.27e-04	652	37	7	GO:0019866
GeneOntologyCellularComponent	mitochondrial inner membrane	TMEM14C AMBP SLC25A20 TMEM14DP SLC1A3 TMEM14B	5.58e-04	593	37	6	GO:0005743
GeneOntologyCellularComponent	mitochondrial membrane	TMEM14C AMBP SLC25A20 TMEM14DP SLC1A3 CYP27C1 TMEM14B	7.09e-04	866	37	7	GO:0031966
GeneOntologyCellularComponent	mitochondrial envelope	TMEM14C AMBP SLC25A20 TMEM14DP SLC1A3 CYP27C1 TMEM14B	9.61e-04	912	37	7	GO:0005740
MousePheno	decreased cellular hemoglobin content	TMEM14C TMEM14DP TMEM14B	6.01e-07	10	25	3	MP:0008956
MousePheno	abnormal cellular hemoglobin content	TMEM14C TMEM14DP TMEM14B	1.10e-06	12	25	3	MP:0008954
Domain	TMEM14	TMEM14C TMEM14DP TMEM14B	7.14e-08	5	37	3	IPR005349
Domain	Tmemb_14	TMEM14C TMEM14DP TMEM14B	7.14e-08	5	37	3	PF03647
Pubmed	TMEM14C is required for erythroid mitochondrial heme metabolism.	TMEM14C TMEM14DP TMEM14B	1.20e-09	3	38	3	25157825
Pubmed	Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.	TMEM14C TMEM14DP TMEM14B	4.20e-08	7	38	3	19656490
Pubmed	Identification of the Mitochondrial Heme Metabolism Complex.	TMEM14C TMEM14DP TMEM14B	1.58e-06	21	38	3	26287972
Pubmed	The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.	ONECUT2 FOXA2	1.74e-05	6	38	2	12781686
Pubmed	NDRG2 and PRA1 interact and synergistically inhibit T-cell factor/β-catenin signaling.	NDRG1 LEF1	2.43e-05	7	38	2	23068607
Pubmed	Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord.	FOXA2 SLC1A3	3.24e-05	8	38	2	34478646
Pubmed	Links between signal transduction, transcription and adhesion in epithelial bud development.	LAMA5 LEF1	3.24e-05	8	38	2	12646922
Pubmed	The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.	LEF1 SLC1A3	6.35e-05	11	38	2	36067402
Pubmed	Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape.	LAMA5 LEF1	6.35e-05	11	38	2	16365040
Pubmed	Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors.	FOXA2 SLC1A3	7.62e-05	12	38	2	18351630
Pubmed	Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation.	NR6A1 FOXA2	7.62e-05	12	38	2	11134352
Pubmed	Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.	FOXA2 SETBP1	9.00e-05	13	38	2	22693459
Pubmed	Epithelial cell plasticity drives endoderm formation during gastrulation.	FOXA2 LEF1	9.00e-05	13	38	2	34168324
Pubmed	Dentate gyrus development requires a cortical hem-derived astrocytic scaffold.	LEF1 SLC1A3	1.05e-04	14	38	2	33393905
Pubmed	Proteomic characterization of the human sperm nucleus.	LAMA5 IZUMO4 DPY19L2 CMAS PSMB5	1.10e-04	438	38	5	21630459
Pubmed	Serum response factor is essential for mesoderm formation during mouse embryogenesis.	FOXA2 LEF1	1.38e-04	16	38	2	9799237
Pubmed	Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal.	FOXA2 SLC1A3	1.96e-04	19	38	2	31461644
Pubmed	Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.	FOXA2 SLC1A3	2.18e-04	20	38	2	19439492
Pubmed	Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.	FOXA2 LEF1	2.18e-04	20	38	2	22573616
Pubmed	Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.	SLC1A3 CRX	2.41e-04	21	38	2	17559664
Pubmed	Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions.	FOXA2 LEF1	2.41e-04	21	38	2	36026468
Pubmed	Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.	LAMA5 LEF1	2.65e-04	22	38	2	16462742
Pubmed	Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.	TMEM14C TMEM14DP MYOZ1 TMEM14B	2.87e-04	292	38	4	12819125
Pubmed	Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis.	LEF1 SLC1A3	2.90e-04	23	38	2	26371318
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ONECUT2 NR6A1 FOXA2 LEF1 CRX	3.01e-04	544	38	5	28473536
Pubmed	BAF (mSWI/SNF) complex regulates mediolateral cortical patterning in the developing forebrain.	LEF1 SLC1A3	3.16e-04	24	38	2	36263009
Pubmed	Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos.	FOXA2 LEF1	3.16e-04	24	38	2	31235634
Pubmed	Deficiency of Wdr60 and Wdr34 cause distinct neural tube malformation phenotypes in early embryos.	FOXA2 LEF1	3.72e-04	26	38	2	37228654
Pubmed	The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium.	NDRG1 FOXA2	3.72e-04	26	38	2	26809587
Pubmed	A census of human transcription factors: function, expression and evolution.	ONECUT2 NR6A1 FOXA2 LEF1 SETBP1 CRX	4.21e-04	908	38	6	19274049
Pubmed	A conserved MST1/2-YAP axis mediates Hippo signaling during lung growth.	NDRG1 FOXA2	4.32e-04	28	38	2	25912685
Pubmed	Secreted frizzled-related proteins are required for Wnt/β-catenin signalling activation in the vertebrate optic cup.	LEF1 CRX	4.32e-04	28	38	2	21896628
Pubmed	Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation.	ONECUT2 CRX	4.32e-04	28	38	2	32744119
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	ONECUT2 CRX	4.96e-04	30	38	2	37048108
Pubmed	Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.	ONECUT2 SLC1A3	4.96e-04	30	38	2	31399471
Pubmed	Molecular design of hypothalamus development.	ONECUT2 SLC1A3	5.30e-04	31	38	2	32499648
Pubmed	Identification of transcripts with enriched expression in the developing and adult pancreas.	STK16 AMBP ONECUT2 FOXA2 SLC31A1	5.63e-04	624	38	5	18554416
Pubmed	Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.	PRTG FOXA2	5.65e-04	32	38	2	38110169
Pubmed	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis.	LAMA5 LEF1	6.76e-04	35	38	2	18676816
Pubmed	Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development.	ONECUT2 CRX	1.02e-03	43	38	2	25228773
Pubmed	Gpr177 regulates pulmonary vasculature development.	FOXA2 LEF1	1.07e-03	44	38	2	23884445
Cytoband	Ensembl 112 genes in cytogenetic band chr9q32	AMBP SLC31A1	7.97e-04	50	38	2	chr9q32
Cytoband	Ensembl 112 genes in cytogenetic band chr6p24	TMEM14C TMEM14B	1.55e-03	70	38	2	chr6p24
Cytoband	1q44	OR2M4 OR2M5	3.78e-03	110	38	2	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2M4 OR2M5	5.08e-03	128	38	2	chr1q44
GeneFamily	Solute carriers	SLC25A20 SLC31A1 SLC1A3 SLC30A6	1.20e-03	395	22	4	752
GeneFamily	Olfactory receptors, family 2	OR2M4 OR2M5	8.24e-03	113	22	2	149
Disease	Blastocyst Disintegration	GRK2 SLC31A1	3.03e-05	7	36	2	C0012684
Disease	Embryo Resorption	GRK2 SLC31A1	3.03e-05	7	36	2	C0013937
Disease	Embryo Disintegration	GRK2 SLC31A1	3.03e-05	7	36	2	C1136082
Disease	Embryo Loss	GRK2 SLC31A1	3.03e-05	7	36	2	C0752351
Disease	Embryo Death	GRK2 SLC31A1	3.03e-05	7	36	2	C0752350
Disease	Congenital Abnormality	GRK2 SLC31A1	7.90e-05	11	36	2	C0000768
Disease	hair colour measurement	NYAP2 NR6A1 LEF1 SLC1A3 SETBP1	8.55e-04	615	36	5	EFO_0007822
Disease	creatinine measurement	LAMA5 WIPI1 NYAP2 NDRG1 SLC1A3 SETBP1	1.19e-03	995	36	6	EFO_0004518
Disease	reticulocyte count	STK16 SLC25A20 WIPI1 NYAP2 SETBP1 PSMB5	1.52e-03	1045	36	6	EFO_0007986
Disease	reticulocyte measurement	STK16 SLC25A20 WIPI1 NYAP2 SETBP1 PSMB5	1.58e-03	1053	36	6	EFO_0010700
Disease	visceral:abdominal adipose tissue ratio measurement	NYAP2 SETBP1	1.85e-03	52	36	2	EFO_0803318
Disease	free cholesterol in very large HDL measurement	WIPI1 NYAP2	2.61e-03	62	36	2	EFO_0022273
Disease	total lipids in very large HDL measurement	WIPI1 NYAP2	2.96e-03	66	36	2	EFO_0022312
Disease	cholesterol in very large HDL measurement	WIPI1 NYAP2	3.23e-03	69	36	2	EFO_0022229
Disease	leucine measurement	NYAP2 NDRG1	3.60e-03	73	36	2	EFO_0009770
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	WIPI1 NYAP2	4.96e-03	86	36	2	EFO_0008595, EFO_0020945

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGMTSRYFYNGTSMA	AMBP	241	P02760
MFSMFKTSMYAGAIP	CYP27C1	261	Q4G0S4
FPGYESGFMLMKNCM	FBN3	1056	Q75N90
MHGYMSKMGNPFLTQ	GRK2	561	P25098
PSYSSYSGYIMMPNM	LEF1	106	Q9UJU2
YSGYIMMPNMNNDPY	LEF1	111	Q9UJU2
MSAYGMPMYKSGDLV	HDGFL1	1	Q5TGJ6
YYGAAMFMYMRPASK	OR2M4	251	Q96R27
MVVGMYYGAGLFMYI	OR2M5	246	A3KFT3
KYFVQGMGYMPSASM	NDRG1	306	Q92597
AMNNLYSPYKEMPGM	ONECUT2	206	O95948
LMRDVPASGMYFMTY	SLC25A20	176	O43772
FYGMSSEMAMKKYAG	GMPR2	266	Q9P2T1
FVMYMGSRQATGDYM	LAMA5	2781	O15230
SYVGKHFRMGFMTMP	NYAP2	86	Q9P242
MMGLFFMYGAYLSGT	DPY19L2	256	Q6NUT2
FYIVAYMPMGASQMS	PRTG	491	Q2VWP7
SGKMGMRAVVYYMTT	SLC1A3	116	P43003
TMFNPCGYSMNGMKS	AMD1	221	P17707
GDSSMMMMPMTFYFG	SLC31A1	36	O15431
QMMDQLYQGKMYFPG	IZUMO4	86	Q1ZYL8
MMAYMNPGPHYSVNA	CRX	1	O43186
PYANMNSMSPMYGQA	FOXA2	126	Q9Y261
GFMAFREQYMGMSVP	NR6A1	206	Q15406
YAMMFGEGPYDMVFQ	STK16	226	O75716
EMGYLQGGKMAYYEM	CMAS	226	Q8NFW8
AGGNMMSQMILGYRY	SEL1L2	211	Q5TEA6
GFSPMNMNNKEYGSM	MED13	846	Q9UHV7
MGMRFYHSGKFMPAG	TMEM14C	76	Q9P0S9
GIMGMRSYYYGKFMP	TMEM14DP	76	A8MWL7
GVMGMRSYYYGKFMP	TMEM14B	76	Q9NUH8
VSPNYNATFMGFKMM	ZNF518A	436	Q6AHZ1
ALMTFGTMYPMSVYS	SLC30A6	236	Q6NXT4
YSPMSQKIMTKMGYI	ERVK-18	111	P63123
MAKGMFTSIEPGYYK	XPNPEP2	546	O43895
SGYMGKMFMAATNYL	WIPI1	276	Q5MNZ9
VYQYKGMGLSMGTMI	PSMB5	146	P28074
YGMPYTSMPMMNLGY	SETBP1	1051	Q9Y6X0
TSMPMMNLGYYGQYP	SETBP1	1056	Q9Y6X0
MPYGGYEKASKRMTF	MYOZ1	226	Q9NP98