Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intramolecular transferase activity	PUSL1 PGM2L1 PGM2 PUS7L	9.18e-06	29	92	4	GO:0016866
GeneOntologyMolecularFunction	alkaline phosphatase activity	ALPI ALPG	3.11e-04	6	92	2	GO:0004035
Domain	LisH	TBL1Y TBL1XR1 TBL1X	8.32e-06	9	88	3	PF08513
Domain	G-protein_beta_WD-40_rep	TBL1Y PRPF19 BUB3 TBL1XR1 TBL1X	5.05e-05	85	88	5	IPR020472
Domain	Alk_phosphatase	ALPI ALPG	1.31e-04	4	88	2	PF00245
Domain	Alkaline_phosphatase_AS	ALPI ALPG	1.31e-04	4	88	2	IPR018299
Domain	Alkaline_phosphatase	ALPI ALPG	1.31e-04	4	88	2	IPR001952
Domain	PGM_PMM_III	PGM2L1 PGM2	1.31e-04	4	88	2	PF02880
Domain	alkPPc	ALPI ALPG	1.31e-04	4	88	2	SM00098
Domain	ALKALINE_PHOSPHATASE	ALPI ALPG	1.31e-04	4	88	2	PS00123
Domain	A-D-PHexomutase_a/b/a-III	PGM2L1 PGM2	1.31e-04	4	88	2	IPR005846
Domain	-	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 BIRC6 TBL1X	1.75e-04	333	88	8	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 BIRC6 TBL1X	1.82e-04	335	88	8	IPR015943
Domain	TF_AP2	TFAP2E TFAP2C	2.17e-04	5	88	2	IPR004979
Domain	TF_AP2_C	TFAP2E TFAP2C	2.17e-04	5	88	2	IPR013854
Domain	PGM_PMM	PGM2L1 PGM2	2.17e-04	5	88	2	PS00710
Domain	PGM_PMM_II	PGM2L1 PGM2	2.17e-04	5	88	2	PF02879
Domain	PGM_PMM_I	PGM2L1 PGM2	2.17e-04	5	88	2	PF02878
Domain	PGM_PMM_IV	PGM2L1 PGM2	2.17e-04	5	88	2	PF00408
Domain	-	PGM2L1 PGM2	2.17e-04	5	88	2	3.40.120.10
Domain	A-D-PHexomutase_a/b/a-I/II/III	PGM2L1 PGM2	2.17e-04	5	88	2	IPR016055
Domain	-	PGM2L1 PGM2	2.17e-04	5	88	2	3.30.310.50
Domain	TF_AP-2	TFAP2E TFAP2C	2.17e-04	5	88	2	PF03299
Domain	A-D-PHexomutase_a/b/a-I	PGM2L1 PGM2	2.17e-04	5	88	2	IPR005844
Domain	A-D-PHexomutase_a/b/a-II	PGM2L1 PGM2	2.17e-04	5	88	2	IPR005845
Domain	A-D-PHexomutase_C	PGM2L1 PGM2	2.17e-04	5	88	2	IPR005843
Domain	Alpha-D-phosphohexomutase_SF	PGM2L1 PGM2	2.17e-04	5	88	2	IPR005841
Domain	WD40	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	2.22e-04	259	88	7	PF00400
Domain	WD40	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	2.73e-04	268	88	7	SM00320
Domain	WD40_repeat	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	2.99e-04	272	88	7	IPR001680
Domain	LisH	TBL1Y TBL1XR1 TBL1X	3.04e-04	28	88	3	SM00667
Domain	LisH	TBL1Y TBL1XR1 TBL1X	3.04e-04	28	88	3	IPR006594
Domain	LISH	TBL1Y TBL1XR1 TBL1X	3.04e-04	28	88	3	PS50896
Domain	Sec23/24_helical_dom	SEC24A SEC24B	3.25e-04	6	88	2	IPR006900
Domain	Sec23_24_beta_S	SEC24A SEC24B	3.25e-04	6	88	2	IPR012990
Domain	zf-Sec23_Sec24	SEC24A SEC24B	3.25e-04	6	88	2	PF04810
Domain	Sec23_trunk	SEC24A SEC24B	3.25e-04	6	88	2	PF04811
Domain	Sec23_helical	SEC24A SEC24B	3.25e-04	6	88	2	PF04815
Domain	Sec23_BS	SEC24A SEC24B	3.25e-04	6	88	2	PF08033
Domain	Sec23/24_trunk_dom	SEC24A SEC24B	3.25e-04	6	88	2	IPR006896
Domain	Znf_Sec23_Sec24	SEC24A SEC24B	3.25e-04	6	88	2	IPR006895
Domain	WD_REPEATS_1	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	3.41e-04	278	88	7	PS00678
Domain	WD_REPEATS_2	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	3.48e-04	279	88	7	PS50082
Domain	WD_REPEATS_REGION	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	3.48e-04	279	88	7	PS50294
Domain	Alkaline_phosphatase_core	SULF2 ALPI ALPG	4.13e-04	31	88	3	IPR017850
Domain	Alkaline_Pase-like_a/b/a	SULF2 ALPI ALPG	4.13e-04	31	88	3	IPR017849
Domain	-	SULF2 ALPI ALPG	4.13e-04	31	88	3	3.40.720.10
Domain	LRRCT	LRIG3 TLR4 TLR5	4.54e-04	32	88	3	PF01463
Domain	WD40_repeat_dom	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	5.07e-04	297	88	7	IPR017986
Domain	SLC26A	SLC26A7 SLC26A1	9.64e-04	10	88	2	PS01130
Domain	WD40_repeat_CS	TBL1Y NUP43 PRPF19 TBL1XR1 TBL1X	1.07e-03	164	88	5	IPR019775
Domain	STAS	SLC26A7 SLC26A1	1.17e-03	11	88	2	PS50801
Domain	STAS_dom	SLC26A7 SLC26A1	1.17e-03	11	88	2	IPR002645
Domain	SLC26A/SulP_dom	SLC26A7 SLC26A1	1.17e-03	11	88	2	IPR011547
Domain	STAS	SLC26A7 SLC26A1	1.17e-03	11	88	2	PF01740
Domain	SLC26A/SulP_fam	SLC26A7 SLC26A1	1.17e-03	11	88	2	IPR001902
Domain	-	SLC26A7 SLC26A1	1.17e-03	11	88	2	3.30.750.24
Domain	Sulfate_transp	SLC26A7 SLC26A1	1.17e-03	11	88	2	PF00916
Domain	PsdUridine_synth_cat_dom	PUSL1 PUS7L	1.66e-03	13	88	2	IPR020103
Domain	Gelsolin	SEC24A SEC24B	1.93e-03	14	88	2	PF00626
Domain	Gelsolin-like_dom	SEC24A SEC24B	1.93e-03	14	88	2	IPR007123
Domain	TIR	TLR4 TLR5	4.35e-03	21	88	2	SM00255
Pathway	REACTOME_NR1H2_AND_NR1H3_MEDIATED_SIGNALING	TBL1Y TBL1XR1 TBL1X	3.52e-05	13	72	3	MM15622
Pathway	REACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA	TBL1Y TBL1XR1 TBL1X	9.87e-05	18	72	3	MM15034
Pathway	REACTOME_METABOLISM_OF_STEROIDS	SEC24A SEC24B CUBN TBL1XR1 CYP46A1 TBL1X	1.33e-04	154	72	6	M27832
Pathway	REACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF	SEC24A SEC24B TBL1XR1 TBL1X	1.75e-04	55	72	4	M27001
Pathway	REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY	TBL1Y TBL1XR1 TBL1X	2.10e-04	23	72	3	MM14954
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1Y TBL1XR1 TBL1X	1.84e-07	5	93	3	21459324
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1Y TBL1XR1 TBL1X	3.68e-07	6	93	3	28348241
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1Y TBL1XR1 TBL1X	6.43e-07	7	93	3	15695367
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1Y TBL1XR1 TBL1X	6.43e-07	7	93	3	27646874
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1Y TBL1XR1 TBL1X	1.03e-06	8	93	3	16127449
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1Y TBL1XR1 TBL1X	1.03e-06	8	93	3	23770565
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1Y TBL1XR1 TBL1X	2.19e-06	10	93	3	14980219
Pubmed	Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex.	OR12D3 OR12D2 OR12D1	5.19e-06	13	93	3	14506126
Pubmed	Molecular identification of mammalian phosphopentomutase and glucose-1,6-bisphosphate synthase, two members of the alpha-D-phosphohexomutase family.	PGM2L1 PGM2	7.07e-06	2	93	2	17804405
Pubmed	Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori.	TLR4 TLR5	7.07e-06	2	93	2	16044857
Pubmed	Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.	TLR4 TLR5	7.07e-06	2	93	2	16891416
Pubmed	The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.	TLK2 TLK1	7.07e-06	2	93	2	21647934
Pubmed	TBL1X: At the crossroads of transcriptional and posttranscriptional regulation.	TBL1XR1 TBL1X	7.07e-06	2	93	2	36206873
Pubmed	Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.	TLR4 TLR5	7.07e-06	2	93	2	16829963
Pubmed	Toll-like receptors 4 and 5 induce distinct types of vasculitis.	TLR4 TLR5	7.07e-06	2	93	2	19150884
Pubmed	Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.	TLK2 TLK1	7.07e-06	2	93	2	32755577
Pubmed	cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.	TLK2 TLK1	7.07e-06	2	93	2	9427565
Pubmed	Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice.	TLR4 TLR5	7.07e-06	2	93	2	25797291
Pubmed	Toll-like Receptors 4 and 5 Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichia coli Infection in Mouse Epididymal Epithelial Cells.	TLR4 TLR5	7.07e-06	2	93	2	26819479
Pubmed	Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice.	SLC26A7 SLC26A1	7.07e-06	2	93	2	28559854
Pubmed	X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats.	TBL1Y TBL1X	7.07e-06	2	93	2	10330347
Pubmed	The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin.	TLR4 TLR5	7.07e-06	2	93	2	33008952
Pubmed	Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance.	TLR4 TLR5	7.07e-06	2	93	2	18590761
Pubmed	Association of TLR4 and TLR5 gene polymorphisms with Graves' disease in Chinese Cantonese population.	TLR4 TLR5	7.07e-06	2	93	2	24830583
Pubmed	Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma.	TLR4 TLR5	7.07e-06	2	93	2	19067129
Pubmed	Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5.	TLR4 TLR5	7.07e-06	2	93	2	20952467
Pubmed	Toll-like receptor triggering in cord blood mesenchymal stem cells.	TLR4 TLR5	7.07e-06	2	93	2	20196781
Pubmed	SUMOylation of TBL1 and TBLR1 promotes androgen-independent prostate cancer cell growth.	TBL1XR1 TBL1X	7.07e-06	2	93	2	27129164
Pubmed	Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.	TLR4 TLR5	7.07e-06	2	93	2	12794153
Pubmed	Toll-like receptors -4 and -5 in oral and cutaneous squamous cell carcinomas.	TLR4 TLR5	7.07e-06	2	93	2	25047824
Pubmed	Transducin β-like 1, X-linked and nuclear receptor co-repressor cooperatively augment the ligand-independent stimulation of TRH and TSHβ gene promoters by thyroid hormone receptors.	TBL1Y TBL1X	7.07e-06	2	93	2	29794369
Pubmed	Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis.	TLR4 TLR5	7.07e-06	2	93	2	26996117
Pubmed	Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.	PRKDC TBL1XR1 TBL1X	8.23e-06	15	93	3	17242407
Pubmed	Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.	CSDE1 PRPF19 PRKDC BUB3 BIRC6 TFRC	9.28e-06	180	93	6	30110629
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	CUBN ALPI ALPG	1.74e-05	19	93	3	31345929
Pubmed	Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.	TLK2 TLK1	2.12e-05	3	93	2	28535374
Pubmed	Tbl1 promotes Wnt-β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells.	TBL1Y TBL1X	2.12e-05	3	93	2	38639717
Pubmed	Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia.	TLR4 TLR5	2.12e-05	3	93	2	21455638
Pubmed	Transducin β-like protein 1 recruits nuclear factor κB to the target gene promoter for transcriptional activation.	TBL1Y TBL1X	2.12e-05	3	93	2	21189284
Pubmed	Attenuated TLRs in middle ear mucosa contributes to susceptibility of chronic suppurative otitis media.	TLR4 TLR5	2.12e-05	3	93	2	24882571
Pubmed	Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.	TLR4 TLR5	2.12e-05	3	93	2	17371986
Pubmed	Organic pyrophosphates as substrates for human alkaline phosphatases.	ALPI ALPG	2.12e-05	3	93	2	16742561
Pubmed	Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide.	TLR4 TLR5	2.12e-05	3	93	2	20566829
Pubmed	Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.	TLR4 TLR5	2.12e-05	3	93	2	28246611
Pubmed	Antigenic analysis of the major human phosphoglucomutase isozymes: PGM1, PGM2, PGM3 and PGM4.	PGM2L1 PGM2	2.12e-05	3	93	2	1840235
Pubmed	Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.	TLR4 TLR5	2.12e-05	3	93	2	25172014
Pubmed	The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.	TLR4 TLR5	2.12e-05	3	93	2	21721932
Pubmed	Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells.	TLR4 TLR5	2.12e-05	3	93	2	17493681
Pubmed	Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.	TLR4 TLR5	2.12e-05	3	93	2	18213697
Pubmed	Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.	ALPI ALPG	2.12e-05	3	93	2	3443302
Pubmed	TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.	TLR4 TLR5	2.12e-05	3	93	2	21182074
Pubmed	ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.	TLR4 TLR5	2.12e-05	3	93	2	22250085
Pubmed	NOD-scid IL2rγnull mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.	TLR4 PRKDC	2.12e-05	3	93	2	36801998
Pubmed	Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.	TLR4 TLR5	2.12e-05	3	93	2	34420402
Pubmed	Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin.	TLR4 TLR5	2.12e-05	3	93	2	18566425
Pubmed	Polymorphisms in toll-like receptors 2, 4 and 5 are associated with Legionella pneumophila infection.	TLR4 TLR5	2.12e-05	3	93	2	23526294
Pubmed	Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages.	TLR4 TLR5	2.12e-05	3	93	2	20196778
Pubmed	Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration.	ALPI ALPG	2.12e-05	3	93	2	19407215
Pubmed	Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer.	FHIT TFAP2C	2.12e-05	3	93	2	19130459
Pubmed	Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.	ALPI ALPG	2.12e-05	3	93	2	2286375
Pubmed	Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants.	TLR4 TLR5	2.12e-05	3	93	2	23867959
Pubmed	The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.	TLK2 TLK1	2.12e-05	3	93	2	38498025
Pubmed	The association of variations in TLR genes and spontaneous immune control of hepatitis B virus.	TLR4 TLR5	2.12e-05	3	93	2	29276096
Pubmed	Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.	TLR4 TLR5	2.12e-05	3	93	2	37330637
Pubmed	Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels.	ALPI ALPG	2.12e-05	3	93	2	27106638
Pubmed	Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse.	ALPI ALPG	2.12e-05	3	93	2	10767088
Pubmed	MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice.	ALPI ALPG	2.12e-05	3	93	2	11722850
Pubmed	Mutant Tbl1x male mice have a short life span and do not breed: unexpected findings.	TBL1Y TBL1X	2.12e-05	3	93	2	38381448
Pubmed	TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.	TLR4 TLR5	2.12e-05	3	93	2	31989925
Pubmed	Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer.	TLR4 TLR5	2.12e-05	3	93	2	18809506
Pubmed	A novel phosphatase upregulated in Akp3 knockout mice.	ALPI ALPG	2.12e-05	3	93	2	17901166
Pubmed	Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.	TLR4 TLR5	2.12e-05	3	93	2	32912327
Pubmed	TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia.	TLR4 TLR5	2.12e-05	3	93	2	18680520
Pubmed	SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.	SLC26A7 SLC26A1	2.12e-05	3	93	2	26671068
Pubmed	Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.	LGR4 ALPI ALPG	3.15e-05	23	93	3	24680895
Pubmed	Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.	ALPI ALPG	4.23e-05	4	93	2	21900644
Pubmed	Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow.	PRKDC TFRC	4.23e-05	4	93	2	32814027
Pubmed	Metagenomic analysis of the effects of toll-like receptors on bacterial infection in the peritoneal cavity following cecum ligation and puncture in mice.	TLR4 TLR5	4.23e-05	4	93	2	31348811
Pubmed	Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency.	ALPI ALPG	4.23e-05	4	93	2	39273477
Pubmed	Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.	TLK2 TLK1	4.23e-05	4	93	2	10523312
Pubmed	A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.	FRAS1 F5	4.23e-05	4	93	2	23703922
Pubmed	Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression.	TLR4 LGR4	4.23e-05	4	93	2	23589304
Pubmed	Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.	TLR5 PRKDC	4.23e-05	4	93	2	26831100
Pubmed	Deletion of TLR5 results in spontaneous colitis in mice.	TLR4 TLR5	4.23e-05	4	93	2	18008007
Pubmed	Damaged spermatogenic cells induce inflammatory gene expression in mouse Sertoli cells through the activation of Toll-like receptors 2 and 4.	TLR4 TLR5	4.23e-05	4	93	2	23123736
Pubmed	Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia.	ALPI ALPG	4.23e-05	4	93	2	9056646
Pubmed	SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells.	TLR4 TLR5	4.23e-05	4	93	2	20364327
Pubmed	Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation.	TLR4 TLR5	4.23e-05	4	93	2	25378591
Pubmed	TBL1-TBLR1 and beta-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis.	TBL1XR1 TBL1X	4.23e-05	4	93	2	18193033
Pubmed	Structural evidence of functional divergence in human alkaline phosphatases.	ALPI ALPG	4.23e-05	4	93	2	12372831
Pubmed	TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.	TBL1XR1 TBL1X	4.23e-05	4	93	2	18374649
Pubmed	Source of biomass cooking fuel determines pulmonary response to household air pollution.	TLR4 TLR5	4.23e-05	4	93	2	24102120
Pubmed	The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion.	SEC24A SEC24B	4.23e-05	4	93	2	32058034
Pubmed	Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.	TLK2 TLK1	4.23e-05	4	93	2	11470414
Pubmed	Stage-specific expression patterns of alkaline phosphatase during development of the first arch skeleton in inbred C57BL/6 mouse embryos.	ALPI ALPG	4.23e-05	4	93	2	9061447
Pubmed	Differences in the expression of TLRs and inflammatory cytokines in pre-eclamptic compared with healthy pregnant women.	TLR4 TLR5	4.23e-05	4	93	2	25549591
Pubmed	Toll-like receptor signaling in airborne Burkholderia thailandensis infection.	TLR4 TLR5	4.23e-05	4	93	2	19797072
Pubmed	Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.	TLK2 TLK1	4.23e-05	4	93	2	20016786
Pubmed	Expression patterns and functions of toll-like receptors in mouse sertoli cells.	TLR4 TLR5	4.23e-05	4	93	2	18499758
Pubmed	Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.	TBL1Y TBL1X	4.23e-05	4	93	2	26070712
Interaction	DDR2 interactions	STIM1 FLG ZFYVE9 SEC24A SEC24B PRKDC TFRC	2.03e-06	136	87	7	int:DDR2
Cytoband	6p22.2-p21.31	OR12D2 OR12D1	4.04e-05	5	93	2	6p22.2-p21.31
Cytoband	8q23	SLC26A7 PKHD1L1	6.08e-04	18	93	2	8q23
GeneFamily	Olfactory receptors, family 12	OR12D3 OR12D2 OR12D1	3.47e-08	3	60	3	160
GeneFamily	WD repeat domain containing	DCAF8L1 TBL1Y NUP43 PRPF19 BUB3 TBL1XR1 TBL1X	2.48e-05	262	60	7	362
GeneFamily	Alkaline phosphatases	ALPI ALPG	6.47e-05	4	60	2	1072
GeneFamily	CD molecules\|Toll like receptors	TLR4 TLR5	4.79e-04	10	60	2	948
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	ZFYVE9 FGD3	4.73e-03	31	60	2	81
GeneFamily	Nucleoporins	NUP210 NUP43	5.04e-03	32	60	2	1051
CoexpressionAtlas	DevelopingLowerUrinaryTract_e15.5_Urothelium_emap-28091_k-means-cluster#3_top-relative-expression-ranked_1000	PCNX4 NUP210 LGR4 CUBN C1QTNF12 TFRC FANCA	1.79e-05	197	88	7	gudmap_developingLowerUrinaryTract_e15.5_Urothelium_1000_k3
ToppCell	Club-club-16\|World / Class top	PASK SULF2 ACSM3 PORCN F5 SLC26A1	1.30e-06	165	93	6	684f3c4872bd630d3f744f15d57dccfd34e96160
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	LRIG3 ATP13A4 FRAS1 TBL1Y LGR4 MMP12	2.02e-06	178	93	6	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	COVID-19-Heart-EC_(POSTN)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRIG3 ANO2 SULF2 MTUS1 F5 PKHD1L1	2.86e-06	189	93	6	7346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLG HOXC8 SLC26A7 CUBN	1.05e-05	65	93	4	db5db7d5811a714535bdb367c5e2863a3edf89a0
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5-Inhibitory_Gad1Gad2_Htr3a.Cpne5_(Interneuron,__(candidate_CGE-derived_5))\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLG HOXC8 SLC26A7 CUBN	1.05e-05	65	93	4	a4873ffa71ac0016c9abce82cb4e1060946627cd
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Cpne5-Inhibitory_Gad1Gad2_Htr3a.Cpne5_(Interneuron,__(candidate_CGE-derived_5))-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	FLG HOXC8 SLC26A7 CUBN	1.05e-05	65	93	4	9cc767bfb26231af3bdb9423978b68ee42797cf4
ToppCell	wk_20-22-Hematologic-Myeloid-HSC/ELP\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MORC1 ZNF620 SLC26A1 TMEM38B ERVFRD-1	2.43e-05	164	93	5	3c07d8f53511f269540bf032738a4ada35650b18
ToppCell	343B-Lymphocytic-NK_cells-Proliferating_NK_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	PASK ZNF620 KIF18B CYP46A1 FANCA	2.80e-05	169	93	5	02fa66a91b8bd2bf971aec4f5ec58318b5bfdf14
ToppCell	15-Airway-Immune-Hematopoietic,_Natural_Killer_Cell\|Airway / Age, Tissue, Lineage and Cell class	KIR3DX1 TFAP2E NUP210 KIF18B FGD3	3.59e-05	178	93	5	0003c3f2561b7a1fd86772bcba59883ba1f17cd2
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHL1 FRAS1 SLC26A7 ASIC1 PKHD1L1	3.59e-05	178	93	5	bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHL1 FRAS1 SLC26A7 ASIC1 PKHD1L1	3.59e-05	178	93	5	c413861148129be1ee94f2ceb5999840217eebe5
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 ATP13A4 FRAS1 OTOGL PKHD1L1	4.21e-05	184	93	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 ATP13A4 FRAS1 OTOGL PKHD1L1	4.21e-05	184	93	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANO2 ATP13A4 FRAS1 OTOGL PKHD1L1	4.21e-05	184	93	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MORC1 SLCO2B1 TLR4 MMP12 TFRC	4.66e-05	188	93	5	fcf1bebef7aa81b4a11c1f9e4319339c290ecd22
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_2-Dcn_2_2-Mgp-Endothelial_Tip.Dcn.Mgp-Clu_(Clu)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KLHL38 SLC26A7 IFI44L CUBN	4.91e-05	96	93	4	9a1da3809073a4321134bf3767e0a40398b69caa
ToppCell	facs-Skin\|facs / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 LRIG3 HOXC8 TFAP2E C1QTNF12	5.02e-05	191	93	5	ae524103331fa53fa82888dbb567fc36abcee7e0
ToppCell	Transverse-T_cell-Treg\|T_cell / Region, Cell class and subclass	PASK TLK1 TLR5 PGM2L1 F5	5.82e-05	197	93	5	b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 LRIG3 TLR5 PUSL1 IFI44L	6.25e-05	200	93	5	68b0f987c4fb8078675475f4f1e71302f832ef69
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CHL1 LRIG3 TLR5 PUSL1 IFI44L	6.25e-05	200	93	5	1b527bebbca1ef8c52449e40beb9358e37494e04
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; PC3; HT_HG-U133A	ACSM3 MTUS1 TBL1Y NUP210 TEX15 TFAP2C TBL1X	1.23e-05	197	89	7	4635_UP
Drug	2-phenylpropionitrile	PORCN FHIT	1.51e-05	2	89	2	CID000015761
Drug	ms37	TLK2 TLK1	1.51e-05	2	89	2	CID016122503
Drug	2'-deoxymugineic acid	MAS1 ZIC1	1.51e-05	2	89	2	CID000189811
Disease	sensory system disease (implicated_via_orthology)	TBL1Y TBL1XR1 TBL1X	2.74e-08	3	90	3	DOID:0050155 (implicated_via_orthology)
Disease	Abnormality of the respiratory system	PPP1R21 SUZ12	9.20e-06	2	90	2	C4018871
Disease	primary immunodeficiency disease (implicated_via_orthology)	TLR4 TLR5	2.75e-05	3	90	2	DOID:612 (implicated_via_orthology)
Disease	Combined immunodeficiency	STIM1 PRKDC TFRC	2.69e-04	41	90	3	C0494261
Disease	ankylosing spondylitis (is_marker_for)	TLR4 TLR5	4.07e-04	10	90	2	DOID:7147 (is_marker_for)
Disease	sleep disorder (implicated_via_orthology)	TFAP2E TFAP2C	4.97e-04	11	90	2	DOID:535 (implicated_via_orthology)
Disease	collagen disease (implicated_via_orthology)	TLR4 TLR5	5.95e-04	12	90	2	DOID:854 (implicated_via_orthology)
Disease	hippocampal atrophy	TLK1 PGM2L1 F5	6.77e-04	56	90	3	EFO_0005039
Disease	glaucoma (implicated_via_orthology)	MAS1 LGR4	1.21e-03	17	90	2	DOID:1686 (implicated_via_orthology)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR4 TLR5	1.21e-03	17	90	2	DOID:8677 (biomarker_via_orthology)
Disease	diet measurement, body mass index	ATP13A4 TBL1XR1	1.69e-03	20	90	2	EFO_0004340, EFO_0008111
Disease	Severe Combined Immunodeficiency	PRKDC TFRC	1.69e-03	20	90	2	C0085110
Disease	longevity	TLK2 KIR3DX1 SUZ12 TEX15 FGD3	1.80e-03	284	90	5	EFO_0004300

Protein segments in the cluster

Peptide	Gene	Start	Entry
SQFTSLAEHQRFHTG	ZNF354C	366	Q86Y25
SHFSLITHGFGSQAI	TFAP2C	391	Q92754
GSGLALAISHASHFL	BIRC6	1756	Q9NR09
TGKSFHVISQHFSSL	ATP13A4	796	Q4VNC1
SVLHSFISGVSGSHV	APOBEC4	196	Q8WW27
VFGLHSASSGHSEFG	BAZ2B	76	Q9UIF8
SFHNIHNTFATGGSD	BUB3	241	O43684
GTVSFHSHSDHRFLG	CSDE1	416	O75534
VSGIFQFSASLHVDH	C1QTNF12	201	Q5T7M4
SGHSGSFLYQVSTHE	FLG	3056	P20930
NGTLHGFVNHTLSFF	ANO2	841	Q9NQ90
SCLTHFSLITHGFGG	TFAP2E	381	Q6VUC0
LFHQGGRSSTFLSHS	NUP43	301	Q8NFH3
HSGGTNLFLTAVHEI	MMP12	206	P39900
HGTTTLAFKFQHGVI	PSMB8	71	P28062
DFIHANSTTHSFLFG	MORC1	16	Q86VD1
NSGDVFHAHSSVLNF	NUP210	1411	Q8TEM1
TIHGINHSFALTLFG	PASK	356	Q96RG2
ERTSNGQHFHLTSTF	FRAS1	2361	Q86XX4
STFGNLHHISLLFST	MAS1	256	P04201
TASNFLGTATHDFHV	CHL1	311	O00533
HAIGKSQSFHTAGSL	MTUS1	176	Q9ULD2
SGSHHQFVTSSGAGF	LRIG3	876	Q6UXM1
SSFFNSVKSIFHGHV	IFI44L	211	Q53G44
SLLHHFAGFSQISKS	PCNX4	371	Q63HM2
GIFNHSPTHTFLFSL	OR2M4	16	Q96R27
ITHHSVGSTGFLTTA	MUC3A	451	Q02505
TTLKFVHTSFHGVGH	PGM2L1	256	Q6PCE3
SSIGLDFSLHGFEHL	GANC	211	Q8TET4
HGVGHSFVQSAFKAF	PGM2	256	Q96G03
FVGNSAFHNLSDLHS	LGR4	286	Q9BXB1
FSNISSIHRFHGQFL	FGD3	201	Q5JSP0
ISQLHFFHSLGSTES	OR12D2	96	P58182
SSVLTNVGAALHGFH	PPP1R21	421	Q6ZMI0
FQHTTHSVLDSFLQG	KIF18B	86	Q86Y91
FQTTGTRSHELHTGL	KIR3DX1	61	Q9H7L2
ITQLHFFHFLGSTEA	OR12D3	96	Q9UGF7
ISQLHFFHFLGSTEA	OR12D1	96	P0DN82
SSSFLQHDAGHLSIF	FADS2B	211	A8MWK0
TLVTADHSHVFSFGG	ALPI	371	P09923
FTEHSGLTTGVAFGH	PRPF19	471	Q9UMS4
SLVTADHSHVFSFGG	ALPG	371	P10696
ASALLHGFSFHLAAV	PORCN	336	Q9H237
HTISLFFHSLGIENS	CUBN	3431	O60494
GTVVEKHFHGTSLTF	FHIT	66	P49789
GFQSKHNSVTHVFGS	IGLL1	86	P15814
HNSVTHVFGSGTQLT	IGLL1	91	P15814
QEHSGIFGFSVSHTT	GUK1	26	Q16774
FVTFFIAGHETSANH	CYP46A1	296	Q9Y6A2
SHGGALTQDITAHFF	FANCA	1121	O15360
FGHLTHDALGLSTFQ	FAM166B	256	A8MTA8
VQDFFHHGTSGISNS	HOXC8	56	P31273
LLGSHAGSVSTIHFN	DCAF8L1	191	A6NGE4
LGSFQGAASSASHLH	SEC24B	131	O95487
HTGFHTLNFTLVNCS	OTOGL	2151	Q3ZCN5
GHVFHSVSSLFINLT	OR11H7	196	Q8NGC8
HLLGTHDFSAFQSAG	PUSL1	171	Q8N0Z8
VAIHLFSPGTSFAGH	RHBDD1	181	Q8TEB9
LSGVFFVHESSQLQH	TMEM150A	191	Q86TG1
GTQNEILTIHFTGHS	F5	616	P12259
HGASLDNFHFIGVSL	LIPI	146	Q6XZB0
DNFHFIGVSLGAHIS	LIPI	151	Q6XZB0
FFNDHVGFHGTIKSS	PUS7L	16	Q9H0K6
GLSIHTFHGNFFVRS	SEC24A	756	O95486
GVTSVFRHSFIINHG	PKDREJ	546	Q9NTG1
HTFNAHAATDITGFG	SEPHS1	256	P49903
KRNTLFGTFHVAHSS	STIM1	386	Q13586
VNAELSFFGHAHLGT	TFRC	291	P02786
FSHSAFTFGIESHIS	TBL1XR1	21	Q9BZK7
LGHFTTVRHGASFTE	TLK2	296	Q86UE8
AHTHSSFGLGLSVNG	ACSM3	246	Q53FZ2
FASSSTLHGLAHIFS	ASIC1	21	P78348
GFSHSAFTFGIESHI	TBL1X	71	O60907
GHFTTVRHGASFTEQ	TLK1	301	Q9UKI8
QLVLHAGDTTNFHFS	GTF2H1	66	P32780
FGTSLTPLFHFHIST	ERVFRD-1	276	P60508
SHFGQLHKRFGSSVA	SLC26A1	306	Q9H2B4
LSHSAFGQAFSKILH	TTI2	21	Q6NXR4
FFIGCSSHQIAGITH	SLCO2B1	461	O94956
LTLHSSEAFLGGHSV	SPATA31D1	381	Q6ZQQ2
HSLSAHLQLTFTGFF	SUZ12	151	Q15022
SSSVFLQHQRFHTGE	ZNF620	291	Q6ZNG0
TLLGSVIFTFQHTQH	TMEM38B	186	Q9NVV0
LLAFLSTQGFHVDHT	TMPRSS9	46	Q7Z410
KTTGTFIGHHNVSFI	PKHD1L1	226	Q86WI1
FSHSAFTFGIESHIS	TBL1Y	21	Q9BQ87
ASLGSSQGSVIHFSH	PRKDC	1541	P78527
AIGVTTFGASRHHSA	ZIC1	11	Q15915
TVHTFGASGHITLNV	TEX15	2591	Q9BXT5
RHLDLSHGFVFSLNS	TLR5	291	O60602
GHHVATGTFALTSLI	SLC26A7	96	Q8TE54
HTHTRVAFNGIFNGL	TLR4	456	O00206
FSLLGGSSAFLSHHR	SULF2	16	Q8IWU5
SFTFRSGLIGHQAIH	ZNF850	401	A8MQ14
SFTFRSGLIGHQAVH	ZNF850	541	A8MQ14
GHSFFSQSFLGSKEH	ZFYVE9	1016	O95405
HRSTAHKNFIFSIGG	KLHL38	376	Q2WGJ6