Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	RFX1_trans_act	RFX2 RFX3	1.78e-05	3	46	2	IPR007668
Domain	RFX1_trans_act	RFX2 RFX3	1.78e-05	3	46	2	PF04589
Domain	DOCK_N	DOCK1 DOCK4	5.91e-05	5	46	2	PF16172
Domain	DOCK_N	DOCK1 DOCK4	5.91e-05	5	46	2	IPR032376
Domain	DNA/RNA_helicase_DEAH_CS	DHX36 FANCM CHD5	8.66e-05	35	46	3	IPR002464
Domain	DEAH_ATP_HELICASE	DHX36 FANCM CHD5	1.11e-04	38	46	3	PS00690
Domain	RFX_DNA_binding	RFX2 RFX3	2.11e-04	9	46	2	PF02257
Domain	DNA-bd_RFX	RFX2 RFX3	2.11e-04	9	46	2	IPR003150
Domain	RFX_DBD	RFX2 RFX3	2.11e-04	9	46	2	PS51526
Domain	DOCK_C	DOCK1 DOCK4	3.22e-04	11	46	2	IPR010703
Domain	DHR-1_domain	DOCK1 DOCK4	3.22e-04	11	46	2	IPR027007
Domain	DHR_2	DOCK1 DOCK4	3.22e-04	11	46	2	PS51651
Domain	DHR_1	DOCK1 DOCK4	3.22e-04	11	46	2	PS51650
Domain	DOCK-C2	DOCK1 DOCK4	3.22e-04	11	46	2	PF14429
Domain	DHR-2	DOCK1 DOCK4	3.22e-04	11	46	2	IPR027357
Domain	DHR-2	DOCK1 DOCK4	3.22e-04	11	46	2	PF06920
Domain	DOCK	DOCK1 DOCK4	3.22e-04	11	46	2	IPR026791
Domain	Helicase_C	DHX36 FANCM CHD5	2.32e-03	107	46	3	PF00271
Domain	HELICc	DHX36 FANCM CHD5	2.32e-03	107	46	3	SM00490
Domain	Helicase_C	DHX36 FANCM CHD5	2.38e-03	108	46	3	IPR001650
Domain	HELICASE_CTER	DHX36 FANCM CHD5	2.45e-03	109	46	3	PS51194
Domain	HELICASE_ATP_BIND_1	DHX36 FANCM CHD5	2.45e-03	109	46	3	PS51192
Domain	DEXDc	DHX36 FANCM CHD5	2.45e-03	109	46	3	SM00487
Domain	Helicase_ATP-bd	DHX36 FANCM CHD5	2.51e-03	110	46	3	IPR014001
Domain	Neurotransmitter_ion_chnl_CS	HTR3A GABRA4	5.49e-03	45	46	2	IPR018000
Domain	Neur_chan_memb	HTR3A GABRA4	5.73e-03	46	46	2	PF02932
Domain	Neur_chan_LBD	HTR3A GABRA4	5.98e-03	47	46	2	PF02931
Domain	NEUROTR_ION_CHANNEL	HTR3A GABRA4	5.98e-03	47	46	2	PS00236
Domain	Neurotrans-gated_channel_TM	HTR3A GABRA4	5.98e-03	47	46	2	IPR006029
Domain	-	HTR3A GABRA4	5.98e-03	47	46	2	2.70.170.10
Domain	Neur_channel	HTR3A GABRA4	5.98e-03	47	46	2	IPR006201
Domain	Neur_chan_lig-bd	HTR3A GABRA4	5.98e-03	47	46	2	IPR006202
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX2 RFX3	5.36e-06	3	47	2	15024578
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX2 RFX3	5.36e-06	3	47	2	12403718
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX2 RFX3	5.36e-06	3	47	2	8289803
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX2 RFX3	5.36e-06	3	47	2	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX2 RFX3	5.36e-06	3	47	2	22415835
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX2 RFX3	5.36e-06	3	47	2	32725242
Pubmed	Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.	C3 PSEN2	1.07e-05	4	47	2	31433986
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX2 RFX3	1.07e-05	4	47	2	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX2 RFX3	1.07e-05	4	47	2	19596083
Pubmed	Identification and characterization of a seven transmembrane hormone receptor using differential display.	C3 RFX2	2.67e-05	6	47	2	9169125
Pubmed	Isolation and characterization of novel presenilin binding protein.	DOCK1 PSEN2	2.67e-05	6	47	2	10854253
Pubmed	RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow.	RFX2 RFX3	3.74e-05	7	47	2	22233545
Pubmed	Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins.	C3 RFX2	6.40e-05	9	47	2	8661125
Pubmed	G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.	RFX2 RFX3	9.75e-05	11	47	2	18218630
Pubmed	Neutrophil-activating therapy for the treatment of cancer.	C3 NCF1B	9.75e-05	11	47	2	36706760
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	SORCS2 PSMD6 DHX36 FLII HDAC11 WDR7 ARHGAP21 RPL7 NDUFV2	1.09e-04	1431	47	9	37142655
Pubmed	The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.	DOCK1 DOCK4	1.38e-04	13	47	2	21930703
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	RFX3 DNAH5	1.38e-04	13	47	2	17884984
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK1 DOCK4	1.61e-04	14	47	2	12432077
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FEM1B DOCK4 UBR5 WDR7 ARHGAP21	2.19e-04	407	47	5	12693553
Pubmed	Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.	RFX2 RFX3	2.40e-04	17	47	2	31068677
Pubmed	In vivo dual-tagging proteomic approach in studying signaling pathways in immune response.	PRPF31 FLII	2.40e-04	17	47	2	15952741
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	PSMD6 DHX36 PTPN11 UBR5	2.70e-04	231	47	4	36597993
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	DOCK1 RFX3 DNAH5	3.41e-04	100	47	3	25807483
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX2 RFX3	3.69e-04	21	47	2	20148032
Pubmed	Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.	DOCK1 DOCK4 PTPN11	3.72e-04	103	47	3	21706016
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DOCK1 DHX36 HDAC11 RPL7 GABRA4	3.92e-04	462	47	5	31138677
Pubmed	The Rfx4 transcription factor modulates Shh signaling by regional control of ciliogenesis.	RFX2 RFX3	4.06e-04	22	47	2	19887680
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	PSMD6 DHX36 PRPF31 FLII RPL7	4.20e-04	469	47	5	37314180
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MRPS10 DHX36 PRPF31 FLII PTPN11 UBR5 RSU1 RPL7	5.62e-04	1415	47	8	28515276
Pubmed	Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.	DOCK1 PTPN11	7.59e-04	30	47	2	24472646
Pubmed	Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress.	C3 NCF1B	8.11e-04	31	47	2	38395995
Pubmed	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	DOCK1 SORCS2 SDK1	9.47e-04	142	47	3	19851296
Pubmed	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	DOCK1 SORCS2 SDK1	9.67e-04	143	47	3	20198315
Pubmed	Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.	PSMD6 UBR5	9.75e-04	34	47	2	32842143
Pubmed	Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.	UBR5 RPL7	1.03e-03	35	47	2	19287380
Pubmed	RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibition.	DHX36 UBR5 CHD5	1.07e-03	148	47	3	35676246
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	SORCS2 ARHGAP21 CHD5	1.17e-03	153	47	3	10718198
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	DHX36 FLII UBR5	1.24e-03	156	47	3	29961565
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	PSMD6 DHX36 PSEN2 RSU1 ARHGAP21	1.32e-03	606	47	5	36538041
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	RFX2 RFX3	1.35e-03	40	47	2	32317081
Cytoband	18p11.22	PIEZO2 NDUFV2	1.38e-04	17	47	2	18p11.22
Cytoband	Ensembl 112 genes in cytogenetic band chr18p11	MC5R PIEZO2 NDUFV2	1.32e-03	210	47	3	chr18p11
Cytoband	19p13.3	GPR108 RFX2 ZNF77	1.86e-03	237	47	3	19p13.3
GeneFamily	Regulatory factor X family	RFX2 RFX3	9.54e-05	8	34	2	1153
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK1 HDAC11 PIEZO2 ARHGAP21 MEGF10	1.87e-06	194	47	5	cb0422e7607dbd77204428b7e2c70dfe14a6ca11
Disease	Schizophrenia	MC5R DOCK4 HTR3A PSEN2 MEGF10 NDUFV2 EDEM2 GABRA4	5.03e-05	883	45	8	C0036341
Disease	tetralogy of Fallot (implicated_via_orthology)	DOCK1 DNAH5	2.05e-04	14	45	2	DOID:6419 (implicated_via_orthology)
Disease	coronary atherosclerosis measurement, traffic air pollution measurement	DOCK1 MEGF10	4.69e-04	21	45	2	EFO_0007908, EFO_0007938
Disease	gestational age	MALRD1 UBR5 SDK1	1.23e-03	138	45	3	EFO_0005112
Disease	facial height measurement	PSEN2 RFX3 NDUFV2	1.34e-03	142	45	3	EFO_0007856
Disease	visceral heterotaxy (implicated_via_orthology)	RFX3 DNAH5	1.46e-03	37	45	2	DOID:0050545 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
TRRDYIMAKYVEHRF	ASAP3	526	Q8TDY4
LELYHTVMYRNYQRK	CHD5	531	Q8TDI0
YEEESCMRYLHRIYV	ABHD2	321	P08910
KRVYIMDVYNRHIYP	HDAC11	196	Q96DB2
SNYYAEMKFYVVIRR	HTR3A	226	P46098
RAHEAKIRYYTYLIM	C3	481	P01024
IYTKLMEYYDRHFTQ	ACSF3	296	Q4G176
MYTKYYIHRIPRSRE	ALG14	96	Q96F25
YRMKGDHLRVYLHYL	DCPS	256	Q96C86
YRTAYRHGEKTMYRR	MEGF10	76	Q96KG7
TVEDTHYVTRMYRVY	FLII	611	Q13045
EIYRYIHYVFDIQML	FANCM	2021	Q8IYD8
KTYHYLYLAMLERFQ	FEM1B	271	Q9UK73
RERVKAMFYHAYDSY	EDEM2	36	Q9BV94
RYVLHYYRTGRLHVM	KCNV1	111	Q6PIU1
GEYIVMTVYFHLRRK	GABRA4	241	P48169
YRFIYMAVQHYIETL	PTPN11	511	Q06124
HYHKEYRQMYRTEIR	RPL7	56	P18124
KRFVPSQHYVRYMFL	NCF1B	16	A6NI72
YYHMFGKRIYRLAIY	MALRD1	946	Q5VYJ5
MPEEIARYYKHYVKV	OSGIN2	171	Q9Y236
FYKEIEREEMYIRYL	DOCK1	1206	Q14185
EEMYIRYIHKLYDLH	DOCK4	1196	Q8N1I0
LIYHLKMRTSSIYLY	DHX36	886	Q9H2U1
LYIFHRLYKDYDMPR	GJB4	146	Q9NTQ9
YVTIFYALRYHHIMT	MC5R	141	P33032
HLKKYRRYEVIMTAY	SDK1	1666	Q7Z5N4
IIEHMTYEVYKYAAR	DNAH5	3871	Q8TE73
HYRYYVREMRIHAYS	PSMD6	291	Q15008
RYVYLLVRHMYRIYG	RNF139	206	Q8WU17
YIRSETYKYLYGRHM	RSU1	236	Q15404
IYKKHRVQYEMRTLY	MRPS10	126	P82664
YCRTYSRHMKYVVRR	TRIM34	366	Q9BYJ4
IRLLYDEYMFYLVEH	RFX2	641	P48378
IRLLYDEYMFYLVEH	RFX3	626	P48380
IVFRYYHKLRMSVEY	JAML	181	Q86YT9
LKLFRHYYVMVICYV	GPR108	441	Q9NPR9
YYVSYRRNEFVLMKL	SORCS2	366	Q96PQ0
YPLYRHFKLVMKAYR	SHQ1	331	Q6PI26
GKTFMYYSYLTRHVR	ZNF77	246	Q15935
RRVFMSYYFLHVVAD	PIEZO2	1426	Q9H5I5
KHRIYEYVESRMSFI	PRPF31	201	Q8WWY3
VMTIFLVVLYKYRCY	PSEN2	151	P49810
MYVVLRGHSLYLYKD	ARHGAP21	961	Q5T5U3
FYMVSYYERNHRIAV	WDR7	1356	Q9Y4E6
VYEYVRKYAEHRMLV	UBR5	2631	O95071
RVYEVATFYTMYNRK	NDUFV2	111	P19404