Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol binding

SNX25 LANCL2

1.03e-02316102GO:0035091
GeneOntologyMolecularFunctionubiquitin protein ligase binding

MAGEA10 USP9X

1.17e-02337102GO:0031625
GeneOntologyMolecularFunctionubiquitin-like protein ligase binding

MAGEA10 USP9X

1.31e-02358102GO:0044389
GeneOntologyBiologicalProcesssomatic diversification of T cell receptor genes

PRKDC LIG4

2.11e-065102GO:0002568
GeneOntologyBiologicalProcesssomatic recombination of T cell receptor gene segments

PRKDC LIG4

2.11e-065102GO:0002681
GeneOntologyBiologicalProcessT cell receptor V(D)J recombination

PRKDC LIG4

2.11e-065102GO:0033153
GeneOntologyBiologicalProcessimmunoglobulin V(D)J recombination

PRKDC LIG4

9.50e-0610102GO:0033152
GeneOntologyBiologicalProcesspro-B cell differentiation

PRKDC LIG4

1.65e-0513102GO:0002328
GeneOntologyBiologicalProcessV(D)J recombination

PRKDC LIG4

5.32e-0523102GO:0033151
GeneOntologyBiologicalProcesslymphoid progenitor cell differentiation

PRKDC LIG4

6.83e-0526102GO:0002320
GeneOntologyBiologicalProcessresponse to gamma radiation

PRKDC LIG4

3.21e-0456102GO:0010332
GeneOntologyBiologicalProcesssomatic recombination of immunoglobulin gene segments

PRKDC LIG4

4.88e-0469102GO:0016447
GeneOntologyBiologicalProcesssomatic diversification of immunoglobulins

PRKDC LIG4

6.07e-0477102GO:0016445
GeneOntologyBiologicalProcessdouble-strand break repair via nonhomologous end joining

PRKDC LIG4

6.07e-0477102GO:0006303
GeneOntologyBiologicalProcesssomatic cell DNA recombination

PRKDC LIG4

6.88e-0482102GO:0016444
GeneOntologyBiologicalProcessreceptor metabolic process

SNX25 USP9X

6.88e-0482102GO:0043112
GeneOntologyBiologicalProcesssomatic diversification of immune receptors via germline recombination within a single locus

PRKDC LIG4

6.88e-0482102GO:0002562
GeneOntologyBiologicalProcesspositive regulation of fibroblast proliferation

PRKDC LIG4

7.39e-0485102GO:0048146
GeneOntologyBiologicalProcesssomatic diversification of immune receptors

PRKDC LIG4

8.47e-0491102GO:0002200
GeneOntologyBiologicalProcessT cell differentiation in thymus

PRKDC LIG4

1.32e-03114102GO:0033077
GeneOntologyBiologicalProcesscell morphogenesis

PRKDC POTEJ FGR USP9X

1.77e-031194104GO:0000902
GeneOntologyBiologicalProcessregulation of fibroblast proliferation

PRKDC LIG4

1.85e-03135102GO:0048145
GeneOntologyBiologicalProcessregulation of circadian rhythm

PRKDC USP9X

1.85e-03135102GO:0042752
GeneOntologyBiologicalProcessimmune response-activating signaling pathway

PRKDC FGR USP9X

2.00e-03553103GO:0002757
GeneOntologyBiologicalProcessresponse to ionizing radiation

PRKDC LIG4

2.31e-03151102GO:0010212
GeneOntologyBiologicalProcessfibroblast proliferation

PRKDC LIG4

2.58e-03160102GO:0048144
GeneOntologyBiologicalProcessimmune response-regulating signaling pathway

PRKDC FGR USP9X

2.71e-03615103GO:0002764
GeneOntologyBiologicalProcessactivation of immune response

PRKDC FGR USP9X

2.81e-03623103GO:0002253
GeneOntologyBiologicalProcessDNA repair

PRKDC LIG4 USP9X

3.14e-03648103GO:0006281
GeneOntologyBiologicalProcesshematopoietic progenitor cell differentiation

PRKDC LIG4

3.88e-03197102GO:0002244
GeneOntologyCellularComponentDNA-dependent protein kinase-DNA ligase 4 complex

PRKDC LIG4

4.32e-067102GO:0005958
GeneOntologyCellularComponentnonhomologous end joining complex

PRKDC LIG4

7.40e-069102GO:0070419
GeneOntologyCellularComponentDNA repair complex

PRKDC LIG4

5.18e-0523102GO:1990391
GeneOntologyCellularComponentactin cytoskeleton

LANCL2 POTEJ FGR

2.16e-03576103GO:0015629
GeneOntologyCellularComponentchromosome, telomeric region

PRKDC LIG4

3.03e-03176102GO:0000781
HumanPhenoSevere combined immunodeficiency

PRKDC LIG4

4.84e-052132HP:0004430
MousePhenoabnormal T cell receptor beta chain V(D)J recombination

PRKDC LIG4

3.22e-06672MP:0008758
MousePhenoabnormal T cell receptor V(D)J recombination

PRKDC LIG4

1.67e-051372MP:0008754
MousePhenodecreased splenocyte number

PRKDC LIG4

8.07e-052872MP:0009339
MousePhenoarrested T cell differentiation

PRKDC LIG4

9.29e-053072MP:0001825
MousePhenoincreased central memory CD8 positive, alpha-beta T cell number

PRKDC LIG4

1.27e-043572MP:0010847
MousePhenoimpaired humoral immune response

PRKDC LIG4

1.66e-044072MP:0020154
MousePhenoincreased effector memory CD4-positive, alpha-beta T cell number

PRKDC LIG4

1.75e-044172MP:0010844
MousePhenoabnormal central memory CD8 positive, alpha-beta T cell morphology

PRKDC LIG4

1.83e-044272MP:0010846
MousePhenoabnormal central memory CD8-positive, alpha-beta T cell number

PRKDC LIG4

1.83e-044272MP:0012772
MousePhenoarrested B cell differentiation

PRKDC LIG4

2.20e-044672MP:0001802
MousePhenoabnormal effector memory CD4-positive, alpha-beta T cell morphology

PRKDC LIG4

2.40e-044872MP:0010843
MousePhenodecreased double-negative T cell number

PRKDC LIG4

2.40e-044872MP:0005089
MousePhenoabnormal effector memory CD4-positive, alpha-beta T cell number

PRKDC LIG4

2.40e-044872MP:0012770
MousePhenoincreased cellular sensitivity to gamma-irradiation

PRKDC LIG4

2.82e-045272MP:0002007
MousePhenoabnormal splenocyte number

PRKDC LIG4

2.82e-045272MP:0009337
MousePhenodecreased CD8-positive, naive alpha-beta T cell number

PRKDC LIG4

2.82e-045272MP:0013435
MousePhenoincreased T cell derived lymphoma incidence

PRKDC LIG4

2.93e-045372MP:0002024
MousePhenoincreased thymus tumor incidence

PRKDC LIG4

3.04e-045472MP:0010365
MousePhenoabnormal CD4-positive, alpha-beta memory T cell morphology

PRKDC LIG4

3.15e-045572MP:0010834
MousePhenoabnormal splenocyte morphology

PRKDC LIG4

3.27e-045672MP:0009332
MousePhenodecreased hematopoietic stem cell number

PRKDC LIG4

3.39e-045772MP:0004810
MousePhenoincreased CD4-positive, alpha-beta memory T cell number

PRKDC LIG4

3.63e-045972MP:0010835
MousePhenoabnormal CD8-positive, naive alpha-beta T cell number

PRKDC LIG4

4.68e-046772MP:0013434
MousePhenoabnormal CD4-positive, alpha-beta memory T cell number

PRKDC LIG4

5.71e-047472MP:0012769
MousePhenoincreased cellular sensitivity to ionizing radiation

PRKDC LIG4

6.83e-048172MP:0004227
MousePhenoincreased NK cell number

PRKDC LIG4

7.00e-048272MP:0008044
MousePhenoincreased CD8-positive, alpha-beta memory T cell number

PRKDC LIG4

7.35e-048472MP:0010838
MousePhenodecreased bone marrow cell number

PRKDC LIG4

7.70e-048672MP:0000333
MousePhenoabnormal T cell apoptosis

PRKDC LIG4

9.00e-049372MP:0006412
MousePhenoabnormal CD8-positive, alpha-beta memory T cell morphology

PRKDC LIG4

1.15e-0310572MP:0010837
MousePhenoabnormal CD8-positive, alpha-beta memory T cell number

PRKDC LIG4

1.15e-0310572MP:0012774
MousePhenodecreased double-positive T cell number

PRKDC LIG4

1.17e-0310672MP:0005092
MousePhenoabnormal hematopoietic stem cell morphology

PRKDC LIG4

1.30e-0311272MP:0004808
MousePhenoabnormal double-negative T cell morphology

PRKDC LIG4

1.30e-0311272MP:0002407
MousePhenodecreased IgM level

PRKDC LIG4

1.37e-0311572MP:0001806
MousePhenoabnormal regulatory T cell morphology

LANCL2 LIG4

1.42e-0311772MP:0004941
MousePhenodecreased macrophage cell number

PRKDC LANCL2

1.44e-0311872MP:0003884
MousePhenoincreased memory T cell number

PRKDC LIG4

1.59e-0312472MP:0008049
MousePhenodecreased thymocyte number

PRKDC LIG4

1.67e-0312772MP:0000715
MousePhenoabnormal DNA repair

PRKDC LIG4

1.75e-0313072MP:0008058
MousePhenoincreased gland tumor incidence

PRKDC LIG4

2.00e-0313972MP:0010288
MousePhenoabnormal double-positive T cell morphology

PRKDC LIG4

2.00e-0313972MP:0002408
MousePhenodecreased T cell number

PRKDC LANCL2 LIG4

2.05e-0356673MP:0005018
MousePhenoabnormal bone marrow cell number

PRKDC LIG4

2.44e-0315472MP:0000172
MousePhenoliver inflammation

PRKDC LIG4

2.50e-0315672MP:0001860
MousePhenodecreased T cell proliferation

PRKDC LIG4

2.54e-0315772MP:0005095
MousePhenoabnormal memory T cell number

PRKDC LIG4

2.70e-0316272MP:0008048
MousePhenoabnormal memory T cell morphology

PRKDC LIG4

2.73e-0316372MP:0010833
MousePhenoincreased lymphoma incidence

PRKDC LIG4

2.76e-0316472MP:0012431
MousePhenoabnormal B cell activation

PRKDC LIG4

2.83e-0316672MP:0008217
MousePhenoabnormal NK cell number

PRKDC LIG4

3.04e-0317272MP:0008043
MousePhenoabnormal NK cell morphology

PRKDC LIG4

3.43e-0318372MP:0005068
MousePhenoincreased sensitivity to induced cell death

PRKDC LIG4

3.46e-0318472MP:0008943
MousePhenoincreased hemolymphoid system tumor incidence

PRKDC LIG4

3.73e-0319172MP:0010296
MousePhenointestinal inflammation

PRKDC LIG4

3.88e-0319572MP:0001858
MousePhenoincreased CD8-positive, alpha-beta T cell number

PRKDC LIG4

3.88e-0319572MP:0008078
MousePhenodecreased CD8-positive, alpha-beta T cell number

PRKDC LIG4

4.83e-0321872MP:0008079
MousePhenodecreased CD4-positive, alpha-beta T cell number

PRKDC LIG4

4.92e-0322072MP:0008075
MousePhenoabnormal IgM level

PRKDC LIG4

5.05e-0322372MP:0020180
MousePhenoabnormal T cell number

PRKDC LANCL2 LIG4

5.85e-0381873MP:0006387
MousePhenoincreased CD4-positive, alpha-beta T cell number

PRKDC LIG4

5.87e-0324172MP:0008074
MousePhenodecreased IgG level

PRKDC LIG4

6.11e-0324672MP:0001805
MousePhenoabnormal induced cell death

PRKDC LIG4

6.60e-0325672MP:0008942
MousePhenoabnormal interferon-gamma secretion

FGR LIG4

6.85e-0326172MP:0008559
DomainTPR-contain_dom

GTF3C3 PRKDC

2.76e-03150102IPR013026
DomainTPR

GTF3C3 PRKDC

3.33e-03165102PS50005
DomainTPR_REGION

GTF3C3 PRKDC

3.33e-03165102PS50293
Domain-

PRKDC USP9X

5.94e-032221021.25.10.10
DomainTPR-like_helical_dom

GTF3C3 PRKDC

6.53e-03233102IPR011990
DomainARM-like

PRKDC USP9X

8.68e-03270102IPR011989
DomainARM-type_fold

PRKDC USP9X

1.34e-02339102IPR016024
DomainKinase-like_dom

PRKDC FGR

3.24e-02542102IPR011009
PathwayWP_NONHOMOLOGOUS_END_JOINING

PRKDC LIG4

6.78e-061062M39469
PathwayKEGG_MEDICUS_REFERENCE_V_D_J_RECOMBINATION

PRKDC LIG4

9.95e-061262M47856
PathwayKEGG_NON_HOMOLOGOUS_END_JOINING

PRKDC LIG4

1.18e-051362M7857
PathwayKEGG_MEDICUS_REFERENCE_NON_HOMOLOGOUS_END_JOINING

PRKDC LIG4

1.18e-051362M47837
PathwayPID_DNA_PK_PATHWAY

PRKDC LIG4

1.81e-051662M42
PathwayREACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ

PRKDC LIG4

1.62e-044762MM15296
PathwayREACTOME_PROTEIN_UBIQUITINATION

PRKDC USP9X

3.10e-046562MM15490
PathwayREACTOME_NONHOMOLOGOUS_END_JOINING_NHEJ

PRKDC LIG4

3.40e-046862M27587
PathwayREACTOME_PROTEIN_UBIQUITINATION

PRKDC USP9X

4.58e-047962M27742
PathwayWP_DNA_REPAIR_PATHWAYS_FULL_NETWORK

PRKDC LIG4

1.05e-0312062M40049
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

PRKDC LIG4

1.56e-0314662MM15292
PathwayREACTOME_DNA_DOUBLE_STRAND_BREAK_REPAIR

PRKDC LIG4

2.10e-0317062M27582
PathwayREACTOME_DNA_REPAIR

PRKDC LIG4

6.44e-0330162MM15433
PathwayREACTOME_DNA_REPAIR

PRKDC LIG4

7.79e-0333262M15434
Pubmed

DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.

PRKDC LIG4

7.44e-08210218508926
Pubmed

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.

PRKDC LIG4

2.23e-07310215194694
Pubmed

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.

PRKDC LIG4

2.23e-07310221245316
Pubmed

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.

PRKDC LIG4

2.23e-0731029259561
Pubmed

Extensive ssDNA end formation at DNA double-strand breaks in non-homologous end-joining deficient cells during the S phase.

PRKDC LIG4

2.23e-07310217963495
Pubmed

Phosphorylated Sp1 is the regulator of DNA-PKcs and DNA ligase IV transcription of daunorubicin-resistant leukemia cell lines.

PRKDC LIG4

2.23e-07310224530422
Pubmed

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

PRKDC LIG4

2.23e-07310217241822
Pubmed

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.

PRKDC LIG4

4.46e-07410222529269
Pubmed

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse.

PRKDC LIG4

4.46e-07410217145779
Pubmed

Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication.

PRKDC LIG4

7.44e-07510219596237
Pubmed

Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.

PRKDC LIG4

7.44e-07510210716994
Pubmed

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development.

PRKDC LIG4

7.44e-07510211248063
Pubmed

DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

PRKDC LIG4

7.44e-07510215520013
Pubmed

Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility.

PRKDC LIG4

7.44e-07510212750264
Pubmed

Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

PRKDC LIG4

7.44e-07510212547193
Pubmed

DNA-PK suppresses a p53-independent apoptotic response to DNA damage.

PRKDC LIG4

1.12e-06610219057578
Pubmed

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.

PRKDC LIG4

1.12e-06610234352203
Pubmed

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.

PRKDC LIG4

1.56e-06710220383123
Pubmed

RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.

PRKDC LIG4

1.56e-06710219092295
Pubmed

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.

PRKDC LIG4

2.08e-06810225941166
Pubmed

The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.

PRKDC FGR

2.08e-06810223896410
Pubmed

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

PRKDC USP9X

7.80e-061510218303054
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

GTF3C3 HSDL2 PRKDC USP9X

1.07e-0553410435032548
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

GTF3C3 PRKDC LANCL2 USP9X

1.40e-0557110437167062
Pubmed

Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.

PRKDC LANCL2 USP9X

1.67e-0518310323956138
Pubmed

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

PRKDC POTEJ

1.71e-052210225331947
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

GTF3C3 HSDL2 PRKDC LANCL2 USP9X

1.77e-05133510529229926
Pubmed

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.

PRKDC LIG4

2.22e-052510215385968
Pubmed

Substrate specificities and identification of putative substrates of ATM kinase family members.

PRKDC LIG4

2.22e-052510210608806
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

GTF3C3 HSDL2 PRKDC LANCL2 USP9X

2.43e-05142510530948266
Pubmed

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.

PRKDC LIG4

2.60e-052710220610542
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

GTF3C3 PRKDC USP9X

2.78e-0521710331685992
Pubmed

Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies.

PRKDC LIG4

3.44e-053110220813000
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

GTF3C3 PRKDC LANCL2

3.62e-0523710329564676
Pubmed

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif.

PRKDC USP9X

5.77e-054010230865227
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

PRKDC USP9X

9.79e-055210224591637
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

GTF3C3 HSDL2 PRKDC USP9X

9.86e-0594210431073040
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

GTF3C3 PRKDC LANCL2

1.22e-0435710337059091
Pubmed

Identification of a USP9X Substrate NFX1-123 by SILAC-Based Quantitative Proteomics.

GTF3C3 PRKDC USP9X

1.51e-0438410331059266
Pubmed

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

GTF3C3 USP9X

1.53e-046510229378950
Pubmed

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.

GTF3C3 PRKDC USP9X

1.66e-0439610326687479
Pubmed

Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.

PRKDC LIG4

1.68e-046810220496165
Pubmed

Variation within DNA repair pathway genes and risk of multiple sclerosis.

PRKDC LIG4

1.88e-047210220522537
Pubmed

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

LANCL2 POTEJ USP9X

1.94e-0441810332552912
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

PRKDC POTEJ FGR USP9X

2.15e-04115310429845934
Pubmed

Proteomic analysis reveals novel ligands and substrates for LNX1 E3 ubiquitin ligase.

PRKDC USP9X

2.27e-047910229121065
Pubmed

HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.

GTF3C3 USP9X

2.75e-048710233711283
InteractionXRCC4 interactions

HSDL2 PRKDC LIG4

2.06e-05114103int:XRCC4
InteractionNHEJ1 interactions

PRKDC LIG4

3.00e-0517102int:NHEJ1
InteractionCUL9 interactions

GTF3C3 POTEJ MAGEA10

6.89e-05171103int:CUL9
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

GTF3C3 PRKDC USP9X

9.12e-06193103abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX25 FGR

5.35e-04157102ec433d2fe827abdb647be4176c231b7052482b6f
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX25 FGR

5.76e-041631028dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SNX25 FGR

5.76e-04163102fd243ca223079033be480a24817a399f281fa4d4
ToppCelldroplet-Lung-21m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LANCL2 FGR

5.90e-04165102354978d4f35154d7b2e36e94de669e045adef512
ToppCelltumor_Lymph_Node_/_Brain-Myeloid_cells-Pleural_Mac|Myeloid_cells / Location, Cell class and cell subclass

SNX25 GTF3C3

6.12e-041681028697b40b2ec2cce68ef3beb4792eb3eff29be053
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_naive-B_naive-5|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LANCL2 LIG4

6.33e-0417110223b3120706bb9c20b9214fe3760c6d7a84f1e749
ToppCell356C-Lymphocytic-ILC-ILC-2|ILC / Donor, Lineage, Cell class and subclass (all cells)

SNX25 LIG4

6.41e-041721024977e1f4deae781750e27a8054deccd336cfb74a
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PRKDC FGR

7.41e-04185102daea170d827226dda6750bf1838ffd82f070c4d4
ToppCell368C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GTF3C3 FGR

7.56e-04187102c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PRKDC LANCL2

8.47e-041981027225a6194c52b01c581e58d3cda107c4af96dc4f
DrugAC1NDYYW

PRKDC FGR LIG4

2.06e-0660103CID004633871
DrugDNA-PK inhibitor

PRKDC LIG4

2.96e-0519102CID000088505
Drug1-(2-trifluoromethoxyphenyl)-2-nitroethanone

HSDL2 FGR USP9X

5.98e-05184103ctd:C576882
Drugnickel chloride

HSDL2 PRKDC FGR LIG4 USP9X

7.45e-051178105ctd:C022838
Drug1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

PRKDC FGR

9.67e-0534102ctd:C569670
DiseaseSevere Combined Immunodeficiency

PRKDC LIG4

1.57e-052092C0085110
DiseaseCombined immunodeficiency

PRKDC LIG4

6.74e-054192C0494261

Protein segments in the cluster

PeptideGeneStartEntry
NMMGLYDGMEHLIYG

MAGEA10

251

P43363
VAEGMAYMERMNYIH

FGR

366

P09769
GAAHGMAGIYYMLMQ

LANCL2

261

Q9NS86
AKYGMSMYVLGMAEE

HSDL2

171

Q6YN16
GERMQMHKDGDVYKY

LIG4

276

P49917
FGGEYMGEVFDHMMK

USP9X

1921

Q93008
FYREHFGMYMERMDK

SNX25

296

Q9H3E2
MMGGMHQKESYVGKE

POTEJ

706

P0CG39
YEQMGDHKMAMDGYR

GTF3C3

261

Q9Y5Q9
MSGKHDVGAYMLMYK

PRKDC

3846

P78527