Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	8.04e-06	2	59	2	GO:0021816
GeneOntologyBiologicalProcess	gamma-tubulin complex localization	CEP72 ZNF365	2.41e-05	3	59	2	GO:0033566
GeneOntologyBiologicalProcess	microtubule-based process	DNAAF8 DNHD1 TCTE1 LRGUK SRGAP2C CEP72 TTC21A DIAPH1 KIF4A KIF4B SRGAP2 GOLGA2	3.73e-05	1058	59	12	GO:0007017
GeneOntologyBiologicalProcess	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	8.00e-05	5	59	2	GO:0021815
GeneOntologyBiologicalProcess	cell motility involved in cerebral cortex radial glia guided migration	SRGAP2C SRGAP2	1.67e-04	7	59	2	GO:0021814
MousePheno	increased dendritic spine number	KIF4A KIF4B	3.60e-05	3	49	2	MP:0021019
Domain	-	TCTE1 LRGUK CEP72 LRRC69 LRRCC1 ZYG11B FBXL20 STK11IP LRRC8D FBXL21P	8.12e-08	321	61	10	3.80.10.10
Domain	L_dom-like	TCTE1 LRGUK CEP72 LRRC69 LRRCC1 ZYG11B FBXL20 STK11IP LRRC8D FBXL21P	9.92e-08	328	61	10	IPR032675
Domain	Leu-rich_rpt	TCTE1 LRGUK CEP72 LRRC69 LRRCC1 ZYG11B FBXL20 STK11IP LRRC8D	2.24e-07	271	61	9	IPR001611
Domain	LRR	LRGUK CEP72 LRRC69 LRRCC1 ZYG11B STK11IP LRRC8D	4.02e-06	201	61	7	PS51450
Domain	srGAP2	SRGAP2C SRGAP2	3.14e-05	3	61	2	IPR030252
Domain	LRR_1	LRGUK CEP72 LRRC69 LRRCC1 FBXL20 LRRC8D	7.87e-05	219	61	6	PF00560
Domain	LRRcap	CEP72 LRRCC1	5.66e-04	11	61	2	SM00446
Domain	U2A'_phosphoprotein32A_C	CEP72 LRRCC1	5.66e-04	11	61	2	IPR003603
Domain	FBOX	FBXL18 FBXL20 FBXL21P	6.54e-04	52	61	3	SM00256
Domain	F-box	FBXL18 FBXL20 FBXL21P	1.37e-03	67	61	3	PF00646
Domain	FBOX	FBXL18 FBXL20 FBXL21P	1.68e-03	72	61	3	PS50181
Domain	F-box_dom	FBXL18 FBXL20 FBXL21P	1.89e-03	75	61	3	IPR001810
Domain	FCH	SRGAP2C SRGAP2	2.32e-03	22	61	2	PF00611
Domain	FCH	SRGAP2C SRGAP2	2.32e-03	22	61	2	SM00055
Domain	FCH_dom	SRGAP2C SRGAP2	2.54e-03	23	61	2	IPR001060
Domain	F_BAR	SRGAP2C SRGAP2	3.00e-03	25	61	2	IPR031160
Domain	F_BAR	SRGAP2C SRGAP2	3.00e-03	25	61	2	PS51741
Domain	LAM_G_DOMAIN	EYS LAMA5	6.84e-03	38	61	2	PS50025
Domain	-	FASN CES4A SPG21	6.94e-03	119	61	3	3.40.50.1820
Domain	AB_hydrolase	FASN CES4A SPG21	6.94e-03	119	61	3	IPR029058
Domain	GDS_CDC24_CS	VAV3 PREX1	7.19e-03	39	61	2	IPR001331
Domain	Laminin_G_2	EYS LAMA5	7.56e-03	40	61	2	PF02210
Domain	Kinesin_motor_CS	KIF4A KIF4B	7.93e-03	41	61	2	IPR019821
Domain	Kinesin-like_fam	KIF4A KIF4B	8.69e-03	43	61	2	IPR027640
Domain	KINESIN_MOTOR_1	KIF4A KIF4B	9.09e-03	44	61	2	PS00411
Domain	-	KIF4A KIF4B	9.09e-03	44	61	2	3.40.850.10
Domain	F-box-like	FBXL20 FBXL21P	9.09e-03	44	61	2	PF12937
Domain	Kinesin_motor_dom	KIF4A KIF4B	9.09e-03	44	61	2	IPR001752
Domain	Kinesin	KIF4A KIF4B	9.09e-03	44	61	2	PF00225
Domain	KINESIN_MOTOR_2	KIF4A KIF4B	9.09e-03	44	61	2	PS50067
Domain	LamG	EYS LAMA5	9.09e-03	44	61	2	SM00282
Domain	KISc	KIF4A KIF4B	9.09e-03	44	61	2	SM00129
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SALL2 TTC28 MYCBP2 CEP72 PREX1 UNC80	2.83e-06	225	61	6	12168954
Pubmed	KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.	KIF4A KIF4B	3.03e-06	2	61	2	36482480
Pubmed	Whole genome expression microarray reveals novel roles for Kif4 in monocyte/macrophage cells.	KIF4A KIF4B	3.03e-06	2	61	2	31486502
Pubmed	Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization.	KIF4A KIF4B	3.03e-06	2	61	2	10773663
Pubmed	The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential.	KIF4A KIF4B	3.03e-06	2	61	2	30081192
Pubmed	Missense Pathogenic variants in KIF4A Affect Dental Morphogenesis Resulting in X-linked Taurodontism, Microdontia and Dens-Invaginatus.	KIF4A KIF4B	3.03e-06	2	61	2	31616463
Pubmed	Chromokinesin Kif4 promotes proper anaphase in mouse oocyte meiosis.	KIF4A KIF4B	3.03e-06	2	61	2	31067151
Pubmed	Kif4 regulates the expression of VEGFR1 through the PI3K/Akt signaling pathway in RAW264.7 monocytes/macrophages.	KIF4A KIF4B	3.03e-06	2	61	2	28350061
Pubmed	SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses.	SRGAP2C SRGAP2	3.03e-06	2	61	2	27373832
Pubmed	Cellular motor protein KIF-4 associates with retroviral Gag.	KIF4A KIF4B	3.03e-06	2	61	2	10559369
Pubmed	Kif4 interacts with EB1 and stabilizes microtubules downstream of Rho-mDia in migrating fibroblasts.	KIF4A KIF4B	3.03e-06	2	61	2	24658398
Pubmed	KIF4 regulates midzone length during cytokinesis.	KIF4A KIF4B	3.03e-06	2	61	2	21565503
Pubmed	A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally.	KIF4A KIF4B	3.03e-06	2	61	2	7929562
Pubmed	Structural basis for the ATP-induced isomerization of kinesin.	KIF4A KIF4B	3.03e-06	2	61	2	23500491
Pubmed	Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.	KIF4A KIF4B	3.03e-06	2	61	2	9658142
Pubmed	Inhibition of SRGAP2 function by its human-specific paralogs induces neoteny during spine maturation.	SRGAP2C SRGAP2	9.07e-06	3	61	2	22559944
Pubmed	Tumor formation via loss of a molecular motor protein.	KIF4A KIF4B	9.07e-06	3	61	2	16890532
Pubmed	KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.	KIF4A KIF4B	9.07e-06	3	61	2	19158085
Pubmed	Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.	KIF4A KIF4B	9.07e-06	3	61	2	10978527
Pubmed	KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.	KIF4A KIF4B	9.07e-06	3	61	2	16630823
Pubmed	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	KIF4A KIF4B	9.07e-06	3	61	2	35579738
Pubmed	Evolution of human-specific neural SRGAP2 genes by incomplete segmental duplication.	SRGAP2C SRGAP2	1.81e-05	4	61	2	22559943
Pubmed	Rho GEFs and cancer: linking gene expression and metastatic dissemination.	VAV3 PREX1	1.81e-05	4	61	2	23033535
Pubmed	Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.	KIF4A KIF4B	1.81e-05	4	61	2	18684836
Pubmed	Kif4 Is Essential for Mouse Oocyte Meiosis.	KIF4A KIF4B	1.81e-05	4	61	2	28125646
Pubmed	Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis.	PECAM1 DIAPH1	1.81e-05	4	61	2	24239357
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PHLDB3 FASN TULP4 MYCBP2 CSAD LAMA5 SRGAP2 EDC4 STK11IP PREX1	2.08e-05	1105	61	10	35748872
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TULP4 SACS CEP72 LRRCC1 ZFC3H1 PREX1 UNC80	2.48e-05	493	61	7	15368895
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	FASN MYCBP2 DIAPH1 ZFC3H1 EDC4	2.87e-05	202	61	5	24639526
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CCT3 MYCBP2 DIAPH1 KIF4A KIF4B SRGAP2 GRIK5 EDC4 GOLGA2	4.40e-05	963	61	9	28671696
Pubmed	Pathogenic variants in MDFIC cause recessive central conducting lymphatic anomaly with lymphedema.	PECAM1 LAMA5	4.52e-05	6	61	2	35235341
Pubmed	P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.	VAV3 PREX1	4.52e-05	6	61	2	25538043
Pubmed	The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.	CCT3 TTC28 SACS EDC4 GOLGA2	5.33e-05	230	61	5	35449600
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	KIF4A KIF4B	6.32e-05	7	61	2	9196009
Pubmed	P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.	VAV3 PREX1	6.32e-05	7	61	2	21178006
Pubmed	Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells.	KIF4A KIF4B	6.32e-05	7	61	2	23362347
Pubmed	Kinesin family in murine central nervous system.	KIF4A KIF4B	6.32e-05	7	61	2	1447303
Pubmed	Genetic variations strongly influence phenotypic outcome in the mouse retina.	KIF4A KIF4B ZNF365	7.38e-05	46	61	3	21779340
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	FASN OPTN CCT3 MYCBP2 CEP72 USP24 DIAPH1 LAMA5 NCOA4 STK11IP	8.02e-05	1297	61	10	33545068
Pubmed	P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.	VAV3 PREX1	8.42e-05	8	61	2	24659802
Pubmed	Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.	PECAM1 LAMA5	8.42e-05	8	61	2	32182215
Pubmed	Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.	PECAM1 LAMA5	8.42e-05	8	61	2	19651211
Pubmed	A mutation affecting laminin alpha 5 polymerisation gives rise to a syndromic developmental disorder.	PECAM1 LAMA5	8.42e-05	8	61	2	32439764
Pubmed	Functional consequences of cell type-restricted expression of laminin α5 in mouse placental labyrinth and kidney glomerular capillaries.	PECAM1 LAMA5	1.35e-04	10	61	2	22911783
Pubmed	Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass.	KIF4A KIF4B	1.35e-04	10	61	2	29101321
Pubmed	Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome.	PECAM1 LAMA5	1.35e-04	10	61	2	15623520
Pubmed	Anuria, omphalocele, and perinatal lethality in mice lacking the CD34-related protein podocalyxin.	PECAM1 LAMA5	1.65e-04	11	61	2	11435469
Pubmed	Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities.	KIF4A KIF4B	1.65e-04	11	61	2	20493910
Pubmed	Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung.	PECAM1 LAMA5	1.65e-04	11	61	2	12051813
Pubmed	Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.	KIF4A KIF4B	1.65e-04	11	61	2	15843429
Pubmed	Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.	PECAM1 LAMA5	1.65e-04	11	61	2	27899284
Pubmed	Identification and comparative analysis of hepatitis C virus-host cell protein interactions.	OPTN MYCBP2	1.65e-04	11	61	2	24136289
Pubmed	Systematic analysis and nomenclature of mammalian F-box proteins.	FBXL18 FBXL20 FBXL21P	1.72e-04	61	61	3	15520277
Pubmed	Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.	PECAM1 LAMA5	1.97e-04	12	61	2	17460146
Pubmed	Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function.	PECAM1 LAMA5	1.97e-04	12	61	2	16750824
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	FBXL18 CCT3 MYCBP2 CEP72 DIAPH1 FBXL20	2.31e-04	495	61	6	27705803
Pubmed	Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development.	PECAM1 LAMA5	2.33e-04	13	61	2	27789626
Pubmed	Tie1 is required for lymphatic valve and collecting vessel development.	PECAM1 LAMA5	2.72e-04	14	61	2	25576926
Pubmed	Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.	FASN PECAM1	2.72e-04	14	61	2	22055502
Pubmed	Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation.	PECAM1 LAMA5	2.72e-04	14	61	2	22665518
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PHLDB3 TTC28 MYCBP2 DIAPH1 KIF4A SRGAP2 NCOA4	2.92e-04	733	61	7	34672954
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	MROH9 TCTE1 TMPRSS15 OPTN SLC44A5 USP24 EDC4 LRRC8D ZNF365	2.99e-04	1242	61	9	30973865
Pubmed	Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane.	PECAM1 LAMA5	3.13e-04	15	61	2	10625553
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNHD1 CCT3 CEP72 ZFC3H1	3.32e-04	187	61	4	26460568
Pubmed	Cell-matrix signals specify bone endothelial cells during developmental osteogenesis.	PECAM1 LAMA5	3.57e-04	16	61	2	28218908
Pubmed	Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2.	PECAM1 LAMA5	3.57e-04	16	61	2	17767158
Pubmed	Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.	PECAM1 LAMA5	3.57e-04	16	61	2	26953188
Pubmed	Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.	PECAM1 LAMA5	3.57e-04	16	61	2	28179430
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	FASN TTC28 MYCBP2 USP24 KIF4A EDC4	4.01e-04	549	61	6	38280479
Pubmed	Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae.	VAV3 PREX1	4.05e-04	17	61	2	21257963
Pubmed	A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.	CNNM2 PECAM1	4.05e-04	17	61	2	21378988
Pubmed	Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation.	PECAM1 LAMA5	4.05e-04	17	61	2	22306086
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	CCT3 MYCBP2 CEP72 LAMA5 EDC4 GOLGA2	4.45e-04	560	61	6	21653829
Pubmed	GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126.	PECAM1 LAMA5	4.55e-04	18	61	2	31582413
Pubmed	Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis.	PECAM1 LAMA5	4.55e-04	18	61	2	19686679
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXL18 FBXL20 FBXL21P	4.58e-04	85	61	3	19028597
Pubmed	CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.	PECAM1 GOLGA2	5.08e-04	19	61	2	35705037
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	MYCBP2 USP24 KIF4A ZFC3H1	5.34e-04	212	61	4	33853758
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	FASN CCT3 USP24 DIAPH1 KIF4A EDC4	5.45e-04	582	61	6	20467437
Pubmed	Multiple roles of lymphatic vessels in peripheral lymph node development.	PECAM1 LAMA5	5.63e-04	20	61	2	30355615
Pubmed	TMED2/emp24 is required in both the chorion and the allantois for placental labyrinth layer development.	PECAM1 GOLGA2	5.63e-04	20	61	2	30236446
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	FASN CCT3 LAMA5	5.95e-04	93	61	3	38245532
Pubmed	Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1.	PECAM1 GOLGA2	6.22e-04	21	61	2	20003423
Pubmed	Pofut1 is required for the proper localization of the Notch receptor during mouse development.	PECAM1 GOLGA2	7.48e-04	23	61	2	18547789
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	FASN CCT3 USP24 DIAPH1 KIF4A SRGAP2 LRRC8D GOLGA2 DNAJC2	7.67e-04	1415	61	9	28515276
Pubmed	ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.	FASN SALL2 CCT3 MYCBP2 KIF4B DNAJC2	7.83e-04	624	61	6	33729478
Pubmed	Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.	PECAM1 GOLGA2	8.15e-04	24	61	2	26060116
Pubmed	Dual role for CXCL12 signaling in semilunar valve development.	PECAM1 GOLGA2	8.15e-04	24	61	2	34433040
Pubmed	Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades.	PECAM1 GOLGA2	8.15e-04	24	61	2	22364862
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FASN SALL2 TTC28 MYCBP2 USP24	8.38e-04	418	61	5	34709266
Pubmed	Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.	CCT3 LAMA5 VAV3	8.71e-04	106	61	3	18654987
Pubmed	Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature.	PECAM1 RUFY4	8.84e-04	25	61	2	38521877
Pubmed	Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis.	PECAM1 GOLGA2	8.84e-04	25	61	2	27471260
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	TTC28 MYCBP2 CEP72 DIAPH1 KIF4A EDC4	9.29e-04	645	61	6	25281560
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FASN CCT3 MYCBP2 USP24 KIF4A EDC4	9.90e-04	653	61	6	22586326
Pubmed	Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.	DIAPH1 SRGAP2	1.36e-03	31	61	2	19041431
Pubmed	Mutagenesis of diploid mammalian genes by gene entrapment.	PECAM1 DCST2 ZFC3H1	1.40e-03	125	61	3	17062627
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	FASN CCT3 EDC4	1.50e-03	128	61	3	28027390
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	FASN CCT3 DIAPH1 EDC4 GOLGA2 GFM2	1.53e-03	711	61	6	33022573
Pubmed	Large-scale identification of genes implicated in kidney glomerulus development and function.	PECAM1 LAMA5	1.64e-03	34	61	2	16498405
Cytoband	2q35	STK11IP UNC80 RUFY4	1.64e-04	79	61	3	2q35
Cytoband	22q12.1	TTC28 C22orf31	8.40e-04	32	61	2	22q12.1
GeneFamily	F-box and leucine rich repeat proteins	FBXL18 FBXL20 FBXL21P	1.02e-05	21	37	3	558
GeneFamily	Rho GTPase activating proteins\|F-BAR domain containing	SRGAP2C SRGAP2	1.00e-03	23	37	2	1288
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF4A KIF4B	3.99e-03	46	37	2	622
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	SACS DNAJC2	4.51e-03	49	37	2	584
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	VAV3 PREX1	8.05e-03	66	37	2	722
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PHLDB3 VAV3 PREX1	8.52e-03	206	37	3	682
Computational	Neighborhood of CDC16	MYCBP2 USP24 DIAPH1 ZFC3H1	5.96e-05	75	31	4	MORF_CDC16
Disease	polycystic ovary syndrome (is_marker_for)	PECAM1 NCOA4	2.56e-04	12	59	2	DOID:11612 (is_marker_for)
Disease	preeclampsia	MYCBP2 CSAD PREX1	5.19e-04	78	59	3	EFO_0000668
Disease	urate measurement, bone density	FAM234B EYS SALL2 TTC28 DIAPH1 LAMA5	1.46e-03	619	59	6	EFO_0003923, EFO_0004531
Disease	bitter non-alcoholic beverage consumption measurement	FAM124B ZNF365	1.88e-03	32	59	2	EFO_0010093
Disease	Inherited neuropathies	SACS SPG21	2.92e-03	40	59	2	C0598589
Disease	emphysema imaging measurement	MROH9 MYCBP2 GRIK5	3.15e-03	146	59	3	EFO_0007626
Disease	hemoglobin A1 measurement	CNNM2 CCT3 TULP4 ZYG11B SRGAP2	3.82e-03	520	59	5	EFO_0007629

Protein segments in the cluster

Peptide	Gene	Start	Entry
GLRQSILLNTRLQDC	C22orf31	16	O95567
NLQIAGLQTSVKRLC	CEP72	551	Q9P209
VGTLQRDLDCLLQQL	DNHD1	4496	Q96M86
LLSCLESLRVSLNNN	DIAPH1	161	O60610
RLELASLQCLNETLT	DNAJC2	386	Q99543
LLQRLCTQLEGLQST	EDC4	971	Q6P2E9
LCNLTQLTTLNLGNN	LRRC69	56	Q6ZNQ3
SQERSRLLELNCLQG	PHLDB3	316	Q6NSJ2
NTNLISLNLRLNCIE	TCTE1	361	Q5JU00
LTILGRNTQICESIN	EYS	1986	Q5T1H1
LTPSQQCLQDSLIRL	TMPRSS15	751	P98073
LRNTDVQGALCQLLV	OR3A3	301	P47888
LLTLLLCSSLEGQEN	PECAM1	16	P16284
NCSNLLITTRQSLVL	FAM234B	396	A2RU67
LITTRQSLVLLRGQN	FAM234B	401	A2RU67
NSTQILVNCLRALSG	CES4A	276	Q5XG92
NLTLSGCNLIDVSIL	LRGUK	131	Q96M69
LDGCILRTNLDTLLQ	MSLNL	331	Q96KJ4
LCQVSLQQGRVSLQL	LAMA5	3171	O15230
ALRVLLNCSGLQQVD	MROH9	451	Q5TGP6
SLRQLSQQLNGLVCE	GOLGA2	126	Q08379
NQVSVCLERLGSLTL	NCOA4	116	Q13772
GSLLQRTLDQLLDCI	FAM124B	21	Q9H5Z6
LLAVGCSLAVRQLQN	GGT6	66	Q6P531
LRTCTGKSQLLQQLR	DNAAF8	426	Q8IYS4
LQCSALLLQDTSNLL	CSAD	311	Q9Y600
ININRGLLCLGNVIS	KIF4A	261	O95239
ININRGLLCLGNVIS	KIF4B	261	Q2VIQ3
NLLRCTSPSVLLNLQ	SLC44A5	96	Q8NCS7
LQQGNISILSRRCLL	DCST2	476	Q5T1A1
RLNCNLTQIGGLLDT	GRIK5	731	Q16478
LLSAACRLQLNGNLQ	FASN	1181	P49327
EQICRQVLLLGSLGQ	SALL2	201	Q9Y467
CSLQGRLQLLLSSEQ	SACS	3996	Q9NZJ4
KLRTLNLGQNCITSL	LRRC8D	776	Q7L1W4
LVCGDTSLNELQIIL	OR10C1	186	Q96KK4
LTVSQLLLCLREGNQ	OPTN	231	Q96CV9
ILSQLVNCSIQTLGL	FBXL21P	136	Q9UKT6
SQLETLICSRSLQAL	STK11IP	131	Q8N1F8
NINGNCTERISRLLL	GFM2	401	Q969S9
LNLQTCLQITDEGLI	FBXL20	226	Q96IG2
VNIGLQCQQLRSLSL	FBXL18	551	Q96ME1
EGSNLTDICTQLLLQ	PREX1	261	Q8TCU6
LVNICLIGTQNLFSL	RNF26	151	Q9BY78
RGQLAEALQLCLLNS	RUFY4	111	Q6ZNE9
TGALLLLTALQLCDQ	ST6GALNAC1	521	Q9NSC7
IRLLLAQCNALVQGT	SLC26A10	501	Q8NG04
LIQNCGASTIRLLTS	CCT3	451	P49368
LVQRCQQLQSRLSTL	SRGAP2C	366	P0DJJ0
LCLRSLQALLNVLQG	MYCBP2	221	O75592
LGQSELASRLTLNCQ	SPG21	191	Q9NZD8
LCSLLLGNVLVNTTL	CNNM2	316	Q9H8M5
SLQLLCQQAIASTLR	TULP4	376	Q9NRJ4
QNLQCLVLNSLTLSL	ZYG11B	136	Q9C0D3
ASNLIEGVCLTLQRQ	UNC80	2611	Q8N2C7
LVQRCQQLQSRLSTL	SRGAP2	366	O75044
SSQTQLRLLQGLCRL	TTC21A	1121	Q8NDW8
GDRLQQCSSTLQSLL	TTC28	1811	Q96AY4
LSLLVTCLQLRSQQL	USP24	1411	Q9UPU5
NISLLTLGQLQNCVI	ZNF365	171	Q70YC4
TGRCQSALAILQNAL	ZFC3H1	1491	O60293
TLRDGVLLCQLLNNL	VAV3	36	Q9UKW4
QLQCLEGLLDNLVSS	LRRCC1	216	Q9C099