Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic anion channel activity	GPR89B GABRR1 GABRR2 CLIC5 GPR89A	1.57e-05	103	61	5	GO:0005253
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	GPR89B GABRR1 GABRR2 CLIC5 GPR89A	9.79e-05	151	61	5	GO:0008509
GeneOntologyMolecularFunction	ATP hydrolysis activity	PMS1 KIF1B SMC5 POLQ DNAH6 ATP2B3 ATP2B4	3.81e-04	441	61	7	GO:0016887
GeneOntologyMolecularFunction	MHC class II receptor activity	HLA-DQA1 HLA-DQA2	4.96e-04	11	61	2	GO:0032395
GeneOntologyMolecularFunction	P-type calcium transporter activity	ATP2B3 ATP2B4	4.96e-04	11	61	2	GO:0005388
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	GPR89B GPR89A	1.21e-03	17	61	2	GO:0008308
GeneOntologyMolecularFunction	GABA-gated chloride ion channel activity	GABRR1 GABRR2	1.36e-03	18	61	2	GO:0022851
GeneOntologyMolecularFunction	GABA-A receptor activity	GABRR1 GABRR2	1.52e-03	19	61	2	GO:0004890
Domain	GABAAa_rho_rcpt	GABRR1 GABRR2	9.15e-06	2	57	2	IPR008057
Domain	KRAB	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.23e-05	358	57	8	PS50805
Domain	KRAB	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.23e-05	358	57	8	PF01352
Domain	KRAB	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.53e-05	369	57	8	SM00349
Domain	KRAB	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.56e-05	370	57	8	IPR001909
Domain	ATP_Ca_trans_C	ATP2B3 ATP2B4	5.47e-05	4	57	2	IPR022141
Domain	P-type_ATPase_IIB	ATP2B3 ATP2B4	5.47e-05	4	57	2	IPR006408
Domain	ATP_Ca_trans_C	ATP2B3 ATP2B4	5.47e-05	4	57	2	PF12424
Domain	C1-set_C	HLA-DQA1 HLA-DQA2	9.10e-05	5	57	2	PF16196
Domain	C1-set_C	HLA-DQA1 HLA-DQA2	9.10e-05	5	57	2	IPR032431
Domain	MHC_II_alpha	HLA-DQA1 HLA-DQA2	9.10e-05	5	57	2	SM00920
Domain	MHC_II_alpha	HLA-DQA1 HLA-DQA2	1.36e-04	6	57	2	PF00993
Domain	MHC_II_a_N	HLA-DQA1 HLA-DQA2	1.90e-04	7	57	2	IPR001003
Domain	zf-C2H2	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	2.31e-04	693	57	9	PF00096
Domain	ZINC_FINGER_C2H2_2	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	5.24e-04	775	57	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	5.34e-04	777	57	9	PS00028
Domain	Znf_C2H2-like	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	6.35e-04	796	57	9	IPR015880
Domain	Znf_C2H2	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	6.88e-04	805	57	9	IPR007087
Domain	ZnF_C2H2	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	7.07e-04	808	57	9	SM00355
Domain	MHC_II_a/b_N	HLA-DQA1 HLA-DQA2	8.13e-04	14	57	2	IPR014745
Domain	-	HLA-DQA1 HLA-DQA2	8.13e-04	14	57	2	3.10.320.10
Domain	-	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.00e-03	679	57	8	3.30.160.60
Domain	-	ATP2B3 ATP2B4	1.07e-03	16	57	2	1.20.1110.10
Domain	ATPase_P-typ_TM_dom	ATP2B3 ATP2B4	1.07e-03	16	57	2	IPR023298
Domain	Znf_C2H2/integrase_DNA-bd	ZNF708 ZNF610 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	1.15e-03	694	57	8	IPR013087
Domain	ATPase_P-typ_cation-transptr_C	ATP2B3 ATP2B4	1.21e-03	17	57	2	IPR006068
Domain	Cation_ATPase_C	ATP2B3 ATP2B4	1.21e-03	17	57	2	PF00689
Domain	Cation_ATPase_N	ATP2B3 ATP2B4	1.36e-03	18	57	2	PF00690
Domain	Cation_ATPase_N	ATP2B3 ATP2B4	1.36e-03	18	57	2	SM00831
Domain	ATPase_P-typ_cation-transptr_N	ATP2B3 ATP2B4	1.51e-03	19	57	2	IPR004014
Domain	GABAA/Glycine_rcpt	GABRR1 GABRR2	2.22e-03	23	57	2	IPR006028
Domain	zf-C2H2_6	ZNF737 ZNF782 ZNF700 ZNF726 ZNF181	2.67e-03	314	57	5	PF13912
Domain	ATPase_P-typ_cyto_domN	ATP2B3 ATP2B4	5.10e-03	35	57	2	IPR023299
Domain	ATPase_P-typ_P_site	ATP2B3 ATP2B4	5.39e-03	36	57	2	IPR018303
Domain	P_typ_ATPase	ATP2B3 ATP2B4	5.39e-03	36	57	2	IPR001757
Domain	ATPASE_E1_E2	ATP2B3 ATP2B4	5.39e-03	36	57	2	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP2B3 ATP2B4	5.69e-03	37	57	2	IPR008250
Domain	E1-E2_ATPase	ATP2B3 ATP2B4	5.69e-03	37	57	2	PF00122
Domain	MHC_I/II-like_Ag-recog	HLA-DQA1 HLA-DQA2	6.00e-03	38	57	2	IPR011162
Domain	Neurotransmitter_ion_chnl_CS	GABRR1 GABRR2	8.33e-03	45	57	2	IPR018000
Domain	Neur_chan_memb	GABRR1 GABRR2	8.69e-03	46	57	2	PF02932
Domain	Neur_chan_LBD	GABRR1 GABRR2	9.06e-03	47	57	2	PF02931
Domain	Neur_channel	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006201
Domain	Neur_chan_lig-bd	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	GABRR1 GABRR2	9.06e-03	47	57	2	PS00236
Domain	Neurotrans-gated_channel_TM	GABRR1 GABRR2	9.06e-03	47	57	2	IPR006029
Domain	-	GABRR1 GABRR2	9.06e-03	47	57	2	2.70.170.10
Pathway	REACTOME_REGULATION_OF_ENDOGENOUS_RETROELEMENTS	ZNF610 ZNF782 ZNF454 ZNF726	2.23e-05	56	42	4	MM17236
Pathway	WP_GPCRS_ODORANT	GPR89B OR7A5 GPR89A GPR160 ADGRG6	9.81e-05	157	42	5	MM15872
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B3 ATP2B4	5.61e-04	12	42	2	M27326
Pathway	REACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION	ZNF610 ZNF782 ZNF454 ZNF726	6.98e-04	136	42	4	MM14848
Pathway	REACTOME_REDUCTION_OF_CYTOSOLIC_CA_LEVELS	ATP2B3 ATP2B4	7.71e-04	14	42	2	MM15052
Pathway	KEGG_MEDICUS_REFERENCE_ANTIGEN_PROCESSING_AND_PRESENTATION_BY_MHC_CLASS_II_MOLECULES	HLA-DQA1 HLA-DQA2	8.88e-04	15	42	2	M47604
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_NFY_MEDIATED_TRANSCRIPTION	HLA-DQA1 HLA-DQA2	8.88e-04	15	42	2	M47588
Pathway	REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE	HLA-DQA1 HLA-DQA2	1.01e-03	16	42	2	MM14808
Pathway	WP_GPCRS_ORPHAN	GPR89B GPR89A	1.43e-03	19	42	2	MM15991
Pathway	REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS	HLA-DQA1 HLA-DQA2	1.43e-03	19	42	2	MM14807
Pathway	REACTOME_PD_1_SIGNALING	HLA-DQA1 HLA-DQA2	1.59e-03	20	42	2	MM15001
Pubmed	A molecular basis for the Ia.2 and Ia.19 antigenic determinants.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	2581258
Pubmed	Analysis of the tissue-specific distribution of mRNAs encoding the plasma membrane calcium-pumping ATPases and characterization of an alternately spliced form of PMCA4 at the cDNA and genomic levels.	ATP2B3 ATP2B4	3.13e-06	2	62	2	1531651
Pubmed	Functional adaptive CD4 Foxp3 T cells develop in MHC class II-deficient mice.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	17142726
Pubmed	The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction.	GABRR1 GABRR2	3.13e-06	2	62	2	9153229
Pubmed	PCR-RFLP genotyping of murine MHC haplotypes.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	8879564
Pubmed	HLA-DQ6 transgenic mice resistance to experimental autoimmune myasthenia gravis is linked to reduced acetylcholine receptor-specific IFN-gamma, IL-2 and IL-10 production.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	11712854
Pubmed	Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	16322110
Pubmed	Targeted disruption of the MHC class II Aa gene in C57BL/6 mice.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	8398989
Pubmed	Impaired ability of MHC class II-/- dendritic cells to provide tumor protection is rescued by CD40 ligation.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	10384102
Pubmed	Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	17947646
Pubmed	Characterization of defective I-A surface expression in a mixed isotype expressing murine B cell lymphoma: continued expression of E alpha d A beta d despite competition from restored A alpha d A beta d pairs.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	1329933
Pubmed	Regions of allelic hypervariability in the murine A alpha immune response gene.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	6309407
Pubmed	Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	7722444
Pubmed	Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	25252912
Pubmed	Elimination of the rho1 subunit abolishes GABA(C) receptor expression and alters visual processing in the mouse retina.	GABRR1 GABRR2	3.13e-06	2	62	2	12019334
Pubmed	A comparative approach linking molecular dynamics of altered peptide ligands and MHC with in vivo immune responses.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	20657836
Pubmed	Gene-based interaction analysis shows GABAergic genes interacting with parenting in adolescent depressive symptoms.	GABRR1 GABRR2	3.13e-06	2	62	2	28660714
Pubmed	Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	2513578
Pubmed	Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	3610256
Pubmed	GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.	GPR89B GPR89A	3.13e-06	2	62	2	18794847
Pubmed	Development of a major histocompatibility complex class II conditional knockout mouse to study cell-specific and time-dependent adaptive immune responses in peripheral nerves.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	38922958
Pubmed	CD8+ T cells are capable of rejecting pancreatic islet xenografts.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	11014643
Pubmed	The class II MHC I-Ag7 molecules from non-obese diabetic mice are poor peptide binders.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	8543793
Pubmed	GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence.	GABRR1 GABRR2	3.13e-06	2	62	2	19536785
Pubmed	GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.	GPR89B GPR89A	3.13e-06	2	62	2	22572823
Pubmed	Major histocompatibility complex class II expression by intrinsic renal cells is required for crescentic glomerulonephritis.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	9687536
Pubmed	Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	9334361
Pubmed	CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses.	HLA-DQA1 HLA-DQA2	3.13e-06	2	62	2	12938235
Pubmed	Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.	CCNT1 HLA-DQA1 HLA-DQA2	4.32e-06	18	62	3	11118314
Pubmed	Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.	CCNT1 HLA-DQA1 HLA-DQA2	4.32e-06	18	62	3	10661406
Pubmed	Revisiting the specificity of the MHC class II transactivator CIITA in vivo.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	16703565
Pubmed	Crystal structure of I-Ak in complex with a dominant epitope of lysozyme.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	9529148
Pubmed	Cloning and characterization of mouse GABA(C) receptor subunits.	GABRR1 GABRR2	9.37e-06	3	62	2	9507960
Pubmed	HLA class II nucleotide sequences, 1992.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	1362295
Pubmed	MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	14991600
Pubmed	Low-Level MHC Class II Expression Leads to Suboptimal Th Cell Response, Increased Autoaggression, and Heightened Cytokine Inducibility.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	28108557
Pubmed	GABAC receptor sensitivity is modulated by interaction with MAP1B.	GABRR1 GABRR2	9.37e-06	3	62	2	11102469
Pubmed	Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation.	GABRR1 GABRR2	9.37e-06	3	62	2	9839716
Pubmed	Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.	GPR89B GPR89A	9.37e-06	3	62	2	32220963
Pubmed	Alternate interactions define the binding of peptides to the MHC molecule IA(b).	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	12084926
Pubmed	Protection from radiation-induced colitis requires MHC class II antigen expression by cells of hemopoietic origin.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	10491007
Pubmed	Circulating, soluble forms of major histocompatibility complex antigens are not exosome-associated.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	17072917
Pubmed	Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	17404272
Pubmed	T cell-dependence of Lassa fever pathogenesis.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	20360949
Pubmed	Implications of aging and self-tolerance on the generation of immune and antitumor immune responses.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	18593945
Pubmed	The class II molecules of the human and murine major histocompatibility complex.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	6198089
Pubmed	Type I IFN-induced, NKT cell-mediated negative control of CD8 T cell priming by dendritic cells.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	18641299
Pubmed	Activated mouse T-cells synthesize MHC class II, process, and present morbillivirus nucleocapsid protein to primed T-cells.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	16083868
Pubmed	A novel inducible von Willebrand Factor Cre recombinase mouse strain to study microvascular endothelial cell-specific biological processes in vivo.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	38554988
Pubmed	Dissecting MHC class II export, B cell maturation, and DM stability defects in invariant chain mutant mice.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	15322189
Pubmed	GABAC receptors are functionally expressed in the intermediate zone and regulate radial migration in the embryonic mouse neocortex.	GABRR1 GABRR2	9.37e-06	3	62	2	20123002
Pubmed	Comparative sequence analysis of cDNA clones encoding I-A molecules of the CH12 B cell lymphoma: nucleotide differences do not account for their "defective" function in B cell stimulation.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	3500915
Pubmed	Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	27592607
Pubmed	Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3.	GABRR1 GABRR2	9.37e-06	3	62	2	10542332
Pubmed	Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	29411880
Pubmed	The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	6300851
Pubmed	Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	9053454
Pubmed	The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	2882518
Pubmed	Life-span, T-cell responses, and incidence of lymphomas in congenic mice.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	7732019
Pubmed	A triad of molecular regions contribute to the formation of two distinct MHC class II conformers.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	27148821
Pubmed	Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	32376649
Pubmed	Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	6584734
Pubmed	Signaling to a B-cell clone by Ek, but not Ak, does not reflect alteration of Ak genes.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	3137158
Pubmed	Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif.	HLA-DQA1 HLA-DQA2	9.37e-06	3	62	2	12589760
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF737 CENPV ZNF726 ZNF181	1.84e-05	181	62	5	37372979
Pubmed	Structural organization, ion transport, and energy transduction of P-type ATPases.	ATP2B3 ATP2B4	1.87e-05	4	62	2	8634322
Pubmed	Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	18799151
Pubmed	The Cdk9 and cyclin T subunits of TAK/P-TEFb localize to splicing factor-rich nuclear speckle regions.	CCNT1 ZMYM6	1.87e-05	4	62	2	11282025
Pubmed	Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons.	ATP2B3 ATP2B4	1.87e-05	4	62	2	12209837
Pubmed	The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	47219
Pubmed	H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	8598041
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B3 ATP2B4	1.87e-05	4	62	2	7989379
Pubmed	HLA variants rs9271366 and rs9275328 are associated with systemic lupus erythematosus susceptibility in Malays and Chinese.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	23257407
Pubmed	Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	11376336
Pubmed	Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps.	ATP2B3 ATP2B4	1.87e-05	4	62	2	11152753
Pubmed	Analysis of MHC class II genes in the susceptibility to lupus in New Zealand mice.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	10072504
Pubmed	MHC class II upregulation and colocalization with Fas in experimental models of immune-mediated bone marrow failure.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	21635935
Pubmed	Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	11465104
Pubmed	Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta.	ATP2B3 ATP2B4	1.87e-05	4	62	2	12784250
Pubmed	Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	1855817
Pubmed	Developmentally regulated expression of GABA receptor rho1 and rho2 subunits, L7 and cone-rod homeobox (CRX) genes in mouse retina.	GABRR1 GABRR2	1.87e-05	4	62	2	11520487
Pubmed	Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	3036828
Pubmed	MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	20696698
Pubmed	Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.	GPR89B GPR89A	1.87e-05	4	62	2	31118204
Pubmed	Calcium pumps of plasma membrane and cell interior.	ATP2B3 ATP2B4	1.87e-05	4	62	2	15101689
Pubmed	A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	3023699
Pubmed	Antigen presentation and T cell development in H2-M-deficient mice.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	8638109
Pubmed	PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†.	ATP2B3 ATP2B4	1.87e-05	4	62	2	36130203
Pubmed	The plasma membrane calcium pump in health and disease.	ATP2B3 ATP2B4	1.87e-05	4	62	2	23413890
Pubmed	The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	16887989
Pubmed	Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.	ATP2B3 ATP2B4	1.87e-05	4	62	2	10434059
Pubmed	Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes.	ATP2B3 ATP2B4	1.87e-05	4	62	2	8245032
Pubmed	Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	7809906
Pubmed	Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.	GABRR1 GABRR2	1.87e-05	4	62	2	20820800
Pubmed	Autonomous maturation of alpha/beta T lineage cells in the absence of COOH-terminal Src kinase (Csk).	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	11283154
Pubmed	Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function.	ATP2B3 ATP2B4	1.87e-05	4	62	2	10577388
Pubmed	Altered major histocompatibility complex class II peptide loading in H2-O-deficient mice.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	11069069
Pubmed	MHC characterization of ALR and ALS mice: respective similarities to the NOD and NON strains.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	10369935
Pubmed	MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	30001419
Pubmed	MHC class II-alpha chain knockout mice support increased viral replication that is independent of their lack of MHC class II cell surface expression and associated immune function deficiencies.	HLA-DQA1 HLA-DQA2	1.87e-05	4	62	2	23840854
Cytoband	19p12	ZNF708 ZNF737 ZNF726	2.53e-04	90	62	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF708 ZNF737 ZNF726	6.18e-04	122	62	3	chr19p12
Cytoband	6q15	GABRR1 GABRR2	8.14e-04	31	62	2	6q15
Cytoband	6p12.3	EFHC1 CLIC5	1.10e-03	36	62	2	6p12.3
Cytoband	19q13.11	GARRE1 ZNF181	1.71e-03	45	62	2	19q13.11
Cytoband	Ensembl 112 genes in cytogenetic band chr6q15	GABRR1 GABRR2	2.19e-03	51	62	2	chr6q15
Cytoband	1q21.1	GPR89B GPR89A	3.22e-03	62	62	2	1q21.1
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF708 ZNF610 ZNF451 ZNF737 ZNF782 ZNF700 ZNF454 ZNF726 ZNF181	2.11e-05	718	40	9	28
GeneFamily	ATPases Ca2+ transporting	ATP2B3 ATP2B4	1.70e-04	9	40	2	1209
GeneFamily	Gamma-aminobutyric acid type A receptor subunits	GABRR1 GABRR2	7.97e-04	19	40	2	563
GeneFamily	C1-set domain containing	HLA-DQA1 HLA-DQA2	3.89e-03	42	40	2	591
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-DQA1 HLA-DQA2	4.26e-03	44	40	2	588
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CADPS PLEKHF2 KIF1B	1.06e-02	206	40	3	682
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	GPR89B CCNT1 TMEM131L GARRE1 ZMYM6	5.80e-06	184	62	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	GPR89B CCNT1 TMEM131L GARRE1 ZMYM6	5.96e-06	185	62	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	GPR89B CCNT1 ZNF708 TMEM131L POLQ	6.96e-06	191	62	5	9454f642c3621370fa23640b631301346b300950
ToppCell	B_cells-Memory_B_cells\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2 TMEM131L	7.14e-06	192	62	5	eef591095921ede098f41a2b81897b18915bb753
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TICRR CENPV C1QTNF2 POLQ ZNF726	7.69e-06	195	62	5	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	B_cells-Memory_B_cells\|B_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2 TMEM131L	8.08e-06	197	62	5	cdd1dbdaf257b0864c6dc8c1cbed6e9b68e114b7
ToppCell	Transplant_Alveoli_and_parenchyma-Endothelial-Endothelial\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	HLA-DQA1 HLA-DQA2 GARRE1 ADGRG6 JAM2	8.70e-06	200	62	5	2ae62c428728c1d9d4471d4be24bd6ab074fa22c
ToppCell	RV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	GABRR1 GABRR2 COL6A3 CATSPERB	3.67e-05	134	62	4	8c4046ba1f85172915a112499e492c3efe8474c2
ToppCell	Dividing_Macrophages-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TICRR ZNF610 ZNF737 POLQ	6.00e-05	152	62	4	e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_11\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 TEX15 ADGRG6	6.31e-05	154	62	4	5967a0a33456d5930fc492a700ebb015ac050abb
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_11\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 TEX15 ADGRG6	6.47e-05	155	62	4	fab281db4c275d51240b122be78713c839ba5a95
ToppCell	normal_Lymph_Node-B_lymphocytes-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	EFHC1 HLA-DQA1 HLA-DQA2 INPP5D	7.68e-05	162	62	4	91ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell	COVID-CD8-exh_CD4\|COVID / Condition, Cell_class and T cell subcluster	TMEM131L ZDBF2 ZNF726 CCDC136	8.44e-05	166	62	4	4ca8c91b03d08489f244898cf9423b9d10348bc8
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 ADGRG6 JAM2	8.44e-05	166	62	4	d373f1092e85eeb317a7406032b259f11e6adbe0
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_2\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 ADGRG6 JAM2	8.44e-05	166	62	4	f453a1d545d59003d98485ac31e85e6cf451817c
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TET2 GPR89B INPP5D ADGRG6	8.84e-05	168	62	4	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 C9orf43 CADPS C1QTNF2	9.90e-05	173	62	4	75e26a65071b0d2f30ed0b2aa9859c488f5cf362
ToppCell	356C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	COL6A3 C9orf43 CADPS C1QTNF2	9.90e-05	173	62	4	26e2e674f5d312fa8f61c11b553dc6101f063b16
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PMS1 ALMS1 HLA-DQA1 ANKRD12	1.03e-04	175	62	4	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C9orf43 INPP5D POLQ CCDC136	1.10e-04	178	62	4	24e8c62060455159235985f456af0c5023a7f3f5
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	C9orf43 INPP5D POLQ CCDC136	1.10e-04	178	62	4	4f1cc954d4d9b5b2b75a4cf995ba81e2ada27084
ToppCell	COVID-19-Myeloid-MoAM4\|Myeloid / Condition, Lineage and Cell class	HLA-DQA1 HLA-DQA2 ZNF726 ATP2B4	1.10e-04	178	62	4	fe0017e6a1f23dc45f644b9acacc7e8aa80d0116
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	GABRR2 GARRE1 ADGRG6 JAM2	1.13e-04	179	62	4	d2db9e70b780643f1e004c41a70464d0abe26088
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPT1B ATP2B4 ADGRG6 JAM2	1.15e-04	180	62	4	67c5068b660cd5e727a665cefe3bd5f8ae887221
ToppCell	Healthy-multiplets\|World / disease group, cell group and cell class	HLA-DQA1 HLA-DQA2 GPR160 ADGRG6	1.18e-04	181	62	4	f8dbac3cd500cc8d80853312b00d124c27b8fd85
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPT1B ATP2B4 ADGRG6 JAM2	1.20e-04	182	62	4	ebc812ed3f25839ea25f76b952c463d79a8325b1
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDBF2 ATP2B4 ADGRG6 JAM2	1.20e-04	182	62	4	c7f2d24697affa530b748ab32b1d40bdc1bdc20a
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDBF2 ATP2B4 ADGRG6 JAM2	1.20e-04	182	62	4	d95635b74e8cd8bc00bfe40340806b59fb9bee43
ToppCell	facs-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CPT1B ATP2B4 ADGRG6 JAM2	1.20e-04	182	62	4	47ff6b4002a4167412c79210651316d1342503f9
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune-Myeloid\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CADPS HLA-DQA1 INPP5D CCDC136	1.23e-04	183	62	4	a97f052950429245c3231464271e1ba539863bba
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ZDBF2 ATP2B4 ADGRG6 JAM2	1.25e-04	184	62	4	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	FAM149B1 GARRE1 JAM2	1.28e-04	70	62	3	37e34ef782b253c43628d5bb2fe5e0294573d0ef
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL6A3 EFHC1 C1QTNF2 ADGRG6	1.28e-04	185	62	4	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	CCNT1 ZNF708 TMEM131L POLQ	1.28e-04	185	62	4	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	droplet-Lung-nan-21m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZDBF2 ATP2B4 ADGRG6 JAM2	1.31e-04	186	62	4	5d0cd07b6b51e8ce9e1da949f757dc4575ec5752
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GREB1L ATP2B4 ADGRG6 JAM2	1.31e-04	186	62	4	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	CCNT1 ZNF708 TMEM131L POLQ	1.31e-04	186	62	4	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CPT1B ATP2B4 ADGRG6 JAM2	1.31e-04	186	62	4	5302399825f213d105ac70b91366a4513b732838
ToppCell	10x3'2.3-week_14-16-Mesenchymal_fibro-stroma-endosteal_fibroblast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	COL6A3 CLIC5 KRT75 C1QTNF2	1.36e-04	188	62	4	0e2d1b21f0a7ee306e7dae16fc8c19d16a467883
ToppCell	ILEUM-non-inflamed-(2)_Memory_B_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.39e-04	189	62	4	8d9b8a952db78646f137526f3175ba502f1d3692
ToppCell	3'_v3-GI_small-bowel-Myeloid_Mac-Cycling_Myeloid-Mac\|GI_small-bowel / Manually curated celltypes from each tissue	TICRR HLA-DQA1 HLA-DQA2 POLQ	1.45e-04	191	62	4	c3944332c5226b0113f8aa9ac07837b755606c6c
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CADPS ZDBF2 ANKRD12 ATP2B3	1.48e-04	192	62	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 C1QTNF2 ITIH3 JAM2	1.51e-04	193	62	4	7cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HLA-DQA1 HLA-DQA2 ADGRG6 JAM2	1.51e-04	193	62	4	daefbfd3a3dd1351fbe94b9abfd807db44d56c24
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 C1QTNF2 ITIH3 JAM2	1.51e-04	193	62	4	96c85b250d04b5f400512097d925061c6dc2906b
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 GPR160 ADGRG6	1.54e-04	194	62	4	b16ed97eb6b7b7a220e943474c0d85c141b6e3a5
ToppCell	PBMC-Control-Myeloid-cDC-cDC-cDC_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 GPR160 ADGRG6	1.54e-04	194	62	4	2210f0755882d8f04edb4c109fb17c3f9149f6f7
ToppCell	normal_Lymph_Node-B_lymphocytes-Follicular_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.54e-04	194	62	4	cd2485ba732ab32b33197bc8f78c755e098f1891
ToppCell	normal_Lymph_Node-B_lymphocytes\|normal_Lymph_Node / Location, Cell class and cell subclass	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.54e-04	194	62	4	cef40ae0bd5c07e73e726100113c46af05548690
ToppCell	NS-critical-d_16-33-Lymphoid-B_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.57e-04	195	62	4	1ce4c9ab82212f399ddba9784d2bcec70b6b98b2
ToppCell	10x5'\|World / Manually curated celltypes from each tissue	COL6A3 HLA-DQA1 HLA-DQA2 TMEM131L	1.57e-04	195	62	4	de28b998793271c4f69ce9e183c3e62d809e9cc8
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 C1QTNF2 ITIH3 JAM2	1.60e-04	196	62	4	308fa54385ca34e9e590967d4553b84aad96c92f
ToppCell	tumor_Lung-T/NK_cells-Exhausted_Tfh\|T/NK_cells / Location, Cell class and cell subclass	COL6A3 HLA-DQA1 HLA-DQA2 ANKRD12	1.60e-04	196	62	4	5a0b5aeff7e535781ea2a4c85799bb468afcb6f8
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_interstitial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	HLA-DQA2 FAM149B1 CPT1B ZMYM6	1.60e-04	196	62	4	e12fc1bfeb42457b204d582d3e19f01e2345cb6a
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	ZNF708 COL6A3 CATSPERB SMC5	1.60e-04	196	62	4	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TEX15 POLQ ADGRG6 JAM2	1.63e-04	197	62	4	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Mesothelial-1\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	ZNF737 C1QTNF2 ZDBF2 ZNF454	1.66e-04	198	62	4	9b1a58fcf818f9c4ae57bbe99655f0a64fe87df7
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NETO2 HLA-DQA1 INPP5D POLQ	1.66e-04	198	62	4	732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCell	356C-Myeloid-Dendritic-cDC_proliferating_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	TICRR NETO2 HLA-DQA1 POLQ	1.66e-04	198	62	4	f801157468e59b5d049f703feadc9bb0f11e85cc
ToppCell	Tracheal-10x5prime-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	INPP5D ZNF454 GARRE1 JAM2	1.66e-04	198	62	4	c77421898cc84ae2e8cc335087198dd05f13bfa5
ToppCell	mLN-B_cell\|mLN / Region, Cell class and subclass	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.69e-04	199	62	4	99c7d157a1e819ff86c526ffd9b7036ed3514cae
ToppCell	Sepsis-Leuk-UTI-Myeloid-tDC\|Leuk-UTI / Disease, condition lineage and cell class	HLA-DQA1 HLA-DQA2 POLQ GPR160	1.69e-04	199	62	4	a2f154b15087803958a656d2a41b6d83fd37b32f
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL6A3 C1QTNF2 ITIH3 JAM2	1.69e-04	199	62	4	eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPR89B CADPS FAM149B1 ZNF700	1.69e-04	199	62	4	6e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	GPR89B CADPS FAM149B1 ZNF700	1.69e-04	199	62	4	5f499595597c10857bba8272f62afe4d32d733ac
ToppCell	mLN-(2)_B_cell\|mLN / shred on region, Cell_type, and subtype	HLA-DQA1 HLA-DQA2 INPP5D PLEKHF2	1.69e-04	199	62	4	9464c8c72a6b2e14a27b413cc1f5d64550212776
ToppCell	Sepsis-Bac-SEP-Lymphocyte-B-B_naive\|Bac-SEP / Disease, condition lineage and cell class	HLA-DQA1 HLA-DQA2 PLEKHF2 GPR160	1.73e-04	200	62	4	d377227314a4684d1bad15a13d87b1fa74b998f1
ToppCell	Sepsis-Leuk-UTI-Myeloid-cDC1\|Leuk-UTI / Disease, condition lineage and cell class	HLA-DQA1 HLA-DQA2 TP53RK GPR160	1.73e-04	200	62	4	186852d54eced4c036876cc891773605068b56b5
ToppCell	Dendritic_Cells-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	HLA-DQA1 HLA-DQA2 RFPL3S	3.66e-04	100	62	3	bb7bd11e28be830f381144d4a6f29a86da59d9fa
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	TICRR HLA-DQA1 CPT1B	4.97e-04	111	62	3	a1b7940c6fa0e5a58aa4798b604469d79f33fa44
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	TICRR HLA-DQA1 CPT1B	4.97e-04	111	62	3	d1ec8e8e9adb11511b4ef363cc6f99286e2cc842
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)-MACROPHAGE_Macrophage.C1qb.Mrc1_(Resident_macrophage)\|Thalamus / BrainAtlas - Mouse McCarroll V32	TICRR HLA-DQA1 CPT1B	4.97e-04	111	62	3	567e5ac2c78d45db207067f0f152bb24ed048c50
ToppCell	Thalamus-Hematopoietic-MACROPHAGE-MP1(C1qb)\|Thalamus / BrainAtlas - Mouse McCarroll V32	TICRR HLA-DQA1 CPT1B	4.97e-04	111	62	3	fd7aa25e83a0d762969e3966a658652da40c490e
ToppCell	Thalamus-Hematopoietic-MACROPHAGE\|Thalamus / BrainAtlas - Mouse McCarroll V32	TICRR HLA-DQA1 CPT1B	4.97e-04	111	62	3	d48561078c387ac856c1c30e3d7a3e75ebde942e
ToppCell	\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TICRR ZDBF2 POLQ	6.39e-04	121	62	3	da8fe561dcf50792d0cbcaad383d564f900a6677
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Nxph1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLIC5 ATP2B4 ADGRG6	6.55e-04	122	62	3	dba1c647172a11381efcb178a23808161908daa3
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALMS1 INPP5D ZNF451	7.36e-04	127	62	3	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b-L6b_ALM_Olfr111_Spon1\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLIC5 ATP2B4 ADGRG6	7.36e-04	127	62	3	cd69ba386796715e87674f8324d2acaad1d4d094
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZHX1-C8orf76 HHLA1 JAM2	8.78e-04	135	62	3	0e5dfbe79598fc7822a7b3baa8d7dba3c9da1dad
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-7\|TCGA-Brain / Sample_Type by Project: Shred V9	TICRR POLQ ZNF726	8.97e-04	136	62	3	d94f0fbeb7b80d4cf0687d1924ebf8f9dd07358c
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	C1QTNF2 POLQ ITIH3	9.16e-04	137	62	3	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	Control-B_naive-11\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	HLA-DQA1 HLA-DQA2 RFPL3S	9.55e-04	139	62	3	2af7ad44b707d139c6f055e63d68c09b5c1bb1be
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L6b\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLIC5 ATP2B4 ADGRG6	9.75e-04	140	62	3	17005ca714ba03d7528fe7979ffb4654a46b666c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6b\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CLIC5 ATP2B4 ADGRG6	9.95e-04	141	62	3	5ef3166c5271aa90fd0633016edfe2c74b835319
ToppCell	Adult-Immune-dendritic_cell-D231\|Adult / Lineage, Cell type, age group and donor	HLA-DQA1 INPP5D TEX15	1.12e-03	147	62	3	7cc4f74dd7a86247db8dc049ed7eadeb53825a96
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|343B / Donor, Lineage, Cell class and subclass (all cells)	ZDBF2 ZNF782 CPT1B	1.17e-03	149	62	3	2a7f71da51c85e04de2123164914122480e60d66
ToppCell	facs-Limb_Muscle-Muscle_Diaphragm-18m-Endothelial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GABRR1 CLIC5 DNAH6	1.19e-03	150	62	3	96b160f163030fbf48aedc37d6ae224e11492c52
ToppCell	TCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8\|TCGA-Bladder / Sample_Type by Project: Shred V9	ZNF708 ZNF737 ZNF726	1.19e-03	150	62	3	1aa9320d97ff10994ea024751790524fe133aba9
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TEX15 ITIH3 JAM2	1.19e-03	150	62	3	909ccab92855f5f049dc29593aadab1ea973297b
ToppCell	Bac-SEP-Lymphocyte-T_NK-Treg\|Bac-SEP / Disease, Lineage and Cell Type	ZHX1-C8orf76 ZDBF2 GARRE1	1.21e-03	151	62	3	5df5e754a45b8a592ca7ad49a70953be1615066a
ToppCell	droplet-Lung-nan-3m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR TMEM131L POLQ	1.24e-03	152	62	3	77b319f594d5e4df29034bbf69c7490076f89dd3
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 ADGRG6	1.26e-03	153	62	3	91e9d70a5d3f6fd68c284ed0cc113f03d7d1e10b
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 ADGRG6	1.26e-03	153	62	3	f17f62646633cf95c810dcd5328978058741b276
ToppCell	343B-Myeloid-Dendritic-cDC1\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CLIC5 NETO2 ADGRG6	1.28e-03	154	62	3	71d33b5dbfab5820e3daddb01806a69116ba8008
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ZHX1-C8orf76 C9orf43 RFPL3S	1.28e-03	154	62	3	3c9d38709f507e91ec3bcc6184cbbfa9b1250128
ToppCell	BAL-Severe-Myeloid-cDC-cDC-cDC_12\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ZHX1-C8orf76 C9orf43 RFPL3S	1.28e-03	154	62	3	1ad4152a3e4bf5912954235fe21c2447e99f3de7
ToppCell	Adult-Immune-dendritic_cell-D122\|Adult / Lineage, Cell type, age group and donor	HLA-DQA1 HLA-DQA2 GPR89A	1.28e-03	154	62	3	64a4686586d08b1e9632dde917b472ac660de2d3
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	HLA-DQA1 HLA-DQA2 GPR160	1.31e-03	155	62	3	ab539c04f10276ae919d82b1c75f99a84eb695bf
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_3\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DQA1 HLA-DQA2 GPR160	1.31e-03	155	62	3	9a27558c457f05808af07190b7a5006b047f1d58
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-liver_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HLA-DQA1 HLA-DQA2 ITIH3	1.33e-03	156	62	3	411c170a7dd65269ae442b8069caf5231bddb116
Disease	Hailey-Hailey disease (implicated_via_orthology)	ATP2B3 ATP2B4	5.67e-05	6	58	2	DOID:0050429 (implicated_via_orthology)
Disease	N-acetylcarnosine measurement	GABRR1 GABRR2	1.06e-04	8	58	2	EFO_0022101
Disease	uveitis (implicated_via_orthology)	HLA-DQA1 HLA-DQA2	2.06e-04	11	58	2	DOID:13141 (implicated_via_orthology)
Disease	esophageal squamous cell carcinoma	HLA-DQA1 HHLA1	2.92e-04	13	58	2	EFO_0005922
Disease	focal segmental glomerulosclerosis	ALMS1 DNAH6	4.48e-04	16	58	2	EFO_0004236
Disease	colorectal cancer, inflammatory bowel disease	ALMS1 HLA-DQA1	6.36e-04	19	58	2	EFO_0003767, MONDO_0005575
Disease	smoking status measurement, chronic obstructive pulmonary disease	TET2 HLA-DQA1 ADGRG6	7.02e-04	88	58	3	EFO_0000341, EFO_0006527
Disease	chronic hepatitis B virus infection	HLA-DQA1 HLA-DQA2	1.02e-03	24	58	2	EFO_0004239
Disease	neutrophil count	TET2 GPR89B EFHC1 HLA-DQA1 HLA-DQA2 INPP5D KIF1B GPR89A ADGRG6	1.42e-03	1382	58	9	EFO_0004833
Disease	Alzheimer disease, peptic ulcer disease	HLA-DQA1 INPP5D	2.69e-03	39	58	2	MONDO_0004247, MONDO_0004975
Disease	peak expiratory flow	TET2 EFHC1 HLA-DQA1 KIF1B ADGRG6	2.95e-03	498	58	5	EFO_0009718
Disease	hepatocellular carcinoma	HLA-DQA1 KIF1B	2.96e-03	41	58	2	EFO_0000182
Disease	central corneal thickness	TET2 COL6A3 EFHC1 SMC5	3.21e-03	309	58	4	EFO_0005213
Disease	diabetic nephropathy	GABRR1 GABRR2 HLA-DQA1	3.24e-03	150	58	3	EFO_0000401
Disease	platelet measurement	EFHC1 HLA-DQA1 KIF1B TMEM131L	3.44e-03	315	58	4	EFO_0005036
Disease	hydroxy-leucine measurement	ALMS1 CADPS	3.56e-03	45	58	2	EFO_0005276
Disease	autism spectrum disorder, schizophrenia	HLA-DQA1 HLA-DQA2 ATP2B4 ITIH3	3.93e-03	327	58	4	EFO_0003756, MONDO_0005090

Protein segments in the cluster

Peptide	Gene	Start	Entry
IKKTFHSFYTSAITF	CATSPERB	451	Q9H7T0
TYLTSKSKSSSTTYF	ADGRG6	1171	Q86SQ4
KSKSSSTTYFKRNSH	ADGRG6	1176	Q86SQ4
LSSSYFHREKSNIFS	ALMS1	2091	Q8TCU4
TSNLAHKTYSLSSSF	CCNT1	551	O60563
NTHYAFSKLTYKSSS	ANKRD12	1601	Q6UB98
FTIQHSKAFSTTKYS	CLIC5	141	Q9NZA1
SFLSKSDHSFFKISY	HLA-DQA1	161	P01909
YLTTHVTKSATSSVF	ATP2B3	1191	Q16720
SSSYIKVVKAFHSSL	ATP2B4	1136	P23634
HAISSAQGKYKAFST	OR7A5	226	Q15622
QHSFTSSDKTIKSFF	C8orf76	191	Q96K31
SSFLSFTVKAASKYV	CADPS	1206	Q9ULU8
TSFLSKSDHSFFKIS	HLA-DQA2	161	P01906
SSSSTTHLFSKCFFY	IRF1-AS1	81	Q8N8D9
AKYLKSSHNSSRTFY	KIF1B	1341	O60333
GHTKSAFSVAVTKSY	C1QTNF2	146	Q9BXJ5
YFSKETSFQKSNSSS	JAM2	266	P57087
TGKVSFLASHFKTTS	GREB1L	601	Q9C091
FSSHSSYTVRSKKIF	GPR160	226	Q9UJ42
AKKSFATSSTQFLEH	DNAH6	111	Q9C0G6
QEFHTTTKLAFYSST	GABRR1	251	P24046
ITLTKFFYAISSSKS	GPR89A	361	B7ZAQ6
ITLTKFFYAISSSKS	GPR89B	361	P0CG08
FTKAHSLLSQSSKFY	C9orf43	76	Q8TAL5
SLLSQSSKFYSKFHG	C9orf43	81	Q8TAL5
HTFISQTKSSYKKLT	POLQ	921	O75417
FSTVFRNSHYSKAAT	GARRE1	101	O15063
VRATYHGSFSTKKSQ	COL6A3	3066	P12111
ITTYTFNTHKAQHTF	CENPV	201	Q7Z7K6
SFKDSTKTAFHRSQT	EFHC1	16	Q5JVL4
TEYSKTCFISSVKHT	PMS1	451	P54277
TIFFHISSKFSSSET	CPT1B	731	Q92523
QKFHTTSRLAFYSST	GABRR2	231	P28476
TKSFAVYAATATEKS	PLEKHF2	106	Q9H8W4
FSSSYAHKASSIAKS	FAM149B1	191	Q96BN6
KRSLFHYTSSITTKF	PNPLA8	186	Q9NP80
KKFFSLLSVTSYSSF	HHLA1	96	C9JL84
SVYYSKHKTSTAAAS	TMEM131L	981	A2VDJ0
YSTKINSKVTSRFAH	ITIH3	46	Q06033
KTKSQTKFYLEFHSS	INPP5D	741	Q92835
STFKKSSYTFKQGHE	NETO2	476	Q8NC67
YTSTQTSSKSFLKSY	CCDC136	776	Q96JN2
KISSSFTTHIFNKYR	ZNF610	166	Q8N9Z0
EKSNLYKFTASASHT	ZNF451	826	Q9Y4E5
FYSAKSFQTHEKTHT	ZNF700	371	Q9H0M5
IKQLSFSRTHSASFY	TICRR	1016	Q7Z2Z1
SFFNSVSSSKIKTFH	RFPL3S	76	P0C7P2
SSSQIKASFSHDFTY	WDR44	786	Q5JSH3
SSHVETTSFSYQKHK	ZDBF2	241	Q9HCK1
FKTASTSFEASNHKF	THUMPD2	451	Q9BTF0
FTKSSTLTYHKVIHT	ZNF708	401	P17019
KAFNQSSNYTTHKVT	ZNF726	236	A6NNF4
SQKVFSSTSVTAYKQ	ZMYM6	251	O95789
KAFSVSSSLTYHQKI	ZNF454	251	Q8N9F8
TVFEAFLKSYSTSSK	TP53RK	216	Q96S44
TFSYQSTFSVHQKVH	ZNF782	346	Q6ZMW2
SVSQRKYYSTKHFSS	TEX15	1051	Q9BXT5
FFSISSKTSNHYSLS	TRIM64C	376	A6NLI5
VKTSFYSNKVISSNT	SMC5	621	Q8IY18
FKQSSVFTKDSFSAT	TET2	381	Q6N021
SFTSSDKTIKSFFPH	ZHX1-C8orf76	161	Q96EF9
KYNIFRSTFHSKSTL	ZNF181	156	Q2M3W8
FKYSSSLTTHKIIHT	ZNF737	406	O75373
VKFVSTTSSSQKSYT	KRT75	536	O95678