Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA2 SMARCA4 CHD9	8.42e-05	37	46	3	GO:0140658
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	SMARCA2 SMARCA4 CHD9 MSH3	2.07e-04	127	46	4	GO:0008094
GeneOntologyBiologicalProcess	regulation of nucleotide-excision repair	SMARCA2 SMARCA4 RAD52	2.97e-05	29	43	3	GO:2000819
GeneOntologyBiologicalProcess	aortic smooth muscle cell differentiation	SMARCA2 SMARCA4	6.33e-05	6	43	2	GO:0035887
GeneOntologyCellularComponent	bBAF complex	SMARCA2 SMARCA4	2.11e-04	10	46	2	GO:0140092
GeneOntologyCellularComponent	npBAF complex	SMARCA2 SMARCA4	4.24e-04	14	46	2	GO:0071564
GeneOntologyCellularComponent	GBAF complex	SMARCA2 SMARCA4	4.24e-04	14	46	2	GO:0140288
GeneOntologyCellularComponent	nBAF complex	SMARCA2 SMARCA4	5.57e-04	16	46	2	GO:0071565
MousePheno	abnormal mast cell physiology	PIP5K1B C3 ENPP3 MILR1	2.53e-05	67	36	4	MP:0002423
Domain	BRK	SMARCA2 SMARCA4 CHD9	3.17e-07	6	48	3	SM00592
Domain	BRK_domain	SMARCA2 SMARCA4 CHD9	3.17e-07	6	48	3	IPR006576
Domain	BRK	SMARCA2 SMARCA4 CHD9	3.17e-07	6	48	3	PF07533
Domain	SnAC	SMARCA2 SMARCA4	6.47e-06	2	48	2	SM01314
Domain	Gln-Leu-Gln_QLQ	SMARCA2 SMARCA4	6.47e-06	2	48	2	IPR014978
Domain	SnAC	SMARCA2 SMARCA4	6.47e-06	2	48	2	IPR029295
Domain	SnAC	SMARCA2 SMARCA4	6.47e-06	2	48	2	PF14619
Domain	QLQ	SMARCA2 SMARCA4	6.47e-06	2	48	2	SM00951
Domain	QLQ	SMARCA2 SMARCA4	6.47e-06	2	48	2	PS51666
Domain	QLQ	SMARCA2 SMARCA4	6.47e-06	2	48	2	PF08880
Domain	HSA	SMARCA2 SMARCA4	3.87e-05	4	48	2	SM00573
Domain	HSA	SMARCA2 SMARCA4	3.87e-05	4	48	2	PS51204
Domain	HSA_dom	SMARCA2 SMARCA4	3.87e-05	4	48	2	IPR014012
Domain	HSA	SMARCA2 SMARCA4	3.87e-05	4	48	2	PF07529
Domain	SNF2_N	SMARCA2 SMARCA4 CHD9	7.50e-05	32	48	3	IPR000330
Domain	SNF2_N	SMARCA2 SMARCA4 CHD9	7.50e-05	32	48	3	PF00176
Domain	Homeobox_KN	TGIF2LX TGIF2LY	8.58e-04	17	48	2	PF05920
Domain	Homeobox_KN_domain	TGIF2LX TGIF2LY	8.58e-04	17	48	2	IPR008422
Domain	Bromodomain_CS	SMARCA2 SMARCA4	2.02e-03	26	48	2	IPR018359
Domain	Helicase_C	SMARCA2 SMARCA4 CHD9	2.62e-03	107	48	3	PF00271
Domain	HELICc	SMARCA2 SMARCA4 CHD9	2.62e-03	107	48	3	SM00490
Domain	Helicase_C	SMARCA2 SMARCA4 CHD9	2.69e-03	108	48	3	IPR001650
Domain	HELICASE_CTER	SMARCA2 SMARCA4 CHD9	2.76e-03	109	48	3	PS51194
Domain	HELICASE_ATP_BIND_1	SMARCA2 SMARCA4 CHD9	2.76e-03	109	48	3	PS51192
Domain	DEXDc	SMARCA2 SMARCA4 CHD9	2.76e-03	109	48	3	SM00487
Domain	-	SMARCA2 SMARCA4 CHD9 MSH3 DNAH8 GIMAP5 BMS1	2.79e-03	746	48	7	3.40.50.300
Domain	Helicase_ATP-bd	SMARCA2 SMARCA4 CHD9	2.84e-03	110	48	3	IPR014001
Domain	BROMODOMAIN_1	SMARCA2 SMARCA4	4.07e-03	37	48	2	PS00633
Domain	Bromodomain	SMARCA2 SMARCA4	4.29e-03	38	48	2	PF00439
Domain	BROMODOMAIN_2	SMARCA2 SMARCA4	4.98e-03	41	48	2	PS50014
Domain	BROMO	SMARCA2 SMARCA4	5.22e-03	42	48	2	SM00297
Domain	Bromodomain	SMARCA2 SMARCA4	5.22e-03	42	48	2	IPR001487
Domain	-	SMARCA2 SMARCA4	5.22e-03	42	48	2	1.20.920.10
Pubmed	The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.	SMARCA2 SMARCA4 SLC4A1	4.04e-07	11	48	3	18094026
Pubmed	The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.	SMARCA2 SMARCA4	1.87e-06	2	48	2	8670841
Pubmed	Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23163725
Pubmed	Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23076393
Pubmed	Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.	SMARCA2 SMARCA4	1.87e-06	2	48	2	9603422
Pubmed	The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.	SMARCA2 SMARCA4	1.87e-06	2	48	2	15576411
Pubmed	Expression of a novel TGIF subclass homeobox gene, Tex1, in the spermatids of mouse testis during spermatogenesis.	TGIF2LX TGIF2LY	1.87e-06	2	48	2	11960710
Pubmed	Association of TGIFLX/Y mRNA expression with prostate cancer.	TGIF2LX TGIF2LY	1.87e-06	2	48	2	18663611
Pubmed	SWI/SNF gene variants and glioma risk and outcome.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23276717
Pubmed	Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.	SMARCA2 SMARCA4	1.87e-06	2	48	2	27097303
Pubmed	Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.	SMARCA2 SMARCA4	1.87e-06	2	48	2	15240517
Pubmed	Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.	SMARCA2 SMARCA4	1.87e-06	2	48	2	26564006
Pubmed	SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.	SMARCA2 SMARCA4	1.87e-06	2	48	2	33027072
Pubmed	SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.	SMARCA2 SMARCA4	1.87e-06	2	48	2	28038711
Pubmed	A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23872584
Pubmed	The human-specific Yp11.2/Xq21.3 homology block encodes a potentially functional testis-specific TGIF-like retroposon.	TGIF2LX TGIF2LY	1.87e-06	2	48	2	12226713
Pubmed	Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23963727
Pubmed	SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.	SMARCA2 SMARCA4	1.87e-06	2	48	2	12493776
Pubmed	Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.	SMARCA2 SMARCA4	1.87e-06	2	48	2	31375262
Pubmed	Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.	SMARCA2 SMARCA4	1.87e-06	2	48	2	23088494
Pubmed	Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.	SMARCA2 SMARCA4	1.87e-06	2	48	2	17075831
Pubmed	SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.	SMARCA2 SMARCA4	1.87e-06	2	48	2	20333683
Pubmed	Association of TGIFLX/Y mRNA expression with azoospermia in infertile men.	TGIF2LX TGIF2LY	1.87e-06	2	48	2	18384077
Pubmed	SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.	SMARCA2 SMARCA4	1.87e-06	2	48	2	34812766
Pubmed	Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.	SMARCA2 SMARCA4	1.87e-06	2	48	2	32855269
Pubmed	Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.	SMARCA2 SMARCA4	1.87e-06	2	48	2	30478150
Pubmed	Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.	SMARCA2 SMARCA4	1.87e-06	2	48	2	22721696
Pubmed	Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.	SMARCA2 SMARCA4	1.87e-06	2	48	2	18508913
Pubmed	Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.	SMARCA2 SMARCA4	1.87e-06	2	48	2	11719516
Pubmed	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.	SMARCA2 SMARCA4	1.87e-06	2	48	2	25808524
Pubmed	Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.	SMARCA2 SMARCA4	1.87e-06	2	48	2	19144648
Pubmed	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.	SMARCA2 SMARCA4	1.87e-06	2	48	2	28706277
Pubmed	Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm-deficient mice.	RAD52 ATM	1.87e-06	2	48	2	15122331
Pubmed	[Expression of BRG1 and BRM proteins in prostatic cancer].	SMARCA2 SMARCA4	1.87e-06	2	48	2	21092585
Pubmed	High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.	SMARCA2 SMARCA4	1.87e-06	2	48	2	29391527
Pubmed	Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.	SMARCA2 SMARCA4	1.87e-06	2	48	2	37634210
Pubmed	SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.	SMARCA2 SMARCA4	1.87e-06	2	48	2	26551623
Pubmed	SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.	SMARCA2 SMARCA4	1.87e-06	2	48	2	19458193
Pubmed	Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.	SMARCA2 SMARCA4	1.87e-06	2	48	2	8208605
Pubmed	The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.	SMARCA2 SMARCA4	1.87e-06	2	48	2	34289068
Pubmed	SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.	SMARCA2 SMARCA4	1.87e-06	2	48	2	34518526
Pubmed	SMARCA family of genes.	SMARCA2 SMARCA4	1.87e-06	2	48	2	32312722
Pubmed	Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.	SMARCA2 SMARCA4	1.87e-06	2	48	2	26356327
Pubmed	Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.	SMARCA2 SMARCA4	1.87e-06	2	48	2	12566296
Pubmed	A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.	SMARCA2 SMARCA4	1.87e-06	2	48	2	11163203
Pubmed	Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.	SMARCA2 SMARCA4	1.87e-06	2	48	2	12620226
Pubmed	SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.	SMARCA2 SMARCA4	1.87e-06	2	48	2	31406271
Pubmed	BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.	SMARCA2 SMARCA4	1.87e-06	2	48	2	27039070
Pubmed	Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.	SMARCA2 SMARCA4	1.87e-06	2	48	2	29848589
Pubmed	Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.	SMARCA2 SMARCA4	1.87e-06	2	48	2	29273066
Pubmed	FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ.	SMARCA2 SMARCA4 CHD9 FBXW2 L3MBTL2	5.44e-06	183	48	5	36129980
Pubmed	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.	SMARCA2 SMARCA4	5.59e-06	3	48	2	28292935
Pubmed	Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.	SMARCA2 SMARCA4	5.59e-06	3	48	2	36464671
Pubmed	DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.	SMARCA2 SMARCA4	5.59e-06	3	48	2	30287812
Pubmed	Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice.	SMARCA4 ATM	5.59e-06	3	48	2	38970714
Pubmed	DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population.	RAD52 MSH3	5.59e-06	3	48	2	23339595
Pubmed	The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes.	SMARCA2 SMARCA4	5.59e-06	3	48	2	17938176
Pubmed	Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.	SMARCA2 SMARCA4	5.59e-06	3	48	2	22740088
Pubmed	BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.	SMARCA2 SMARCA4	5.59e-06	3	48	2	15034933
Pubmed	TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.	SMARCA2 SMARCA4	5.59e-06	3	48	2	15075294
Pubmed	A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.	SMARCA2 SMARCA4	5.59e-06	3	48	2	12044884
Pubmed	SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.	SMARCA2 SMARCA4	5.59e-06	3	48	2	21518954
Pubmed	Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.	SMARCA2 SMARCA4	5.59e-06	3	48	2	19784067
Pubmed	Characterization of mammary tumors from Brg1 heterozygous mice.	SMARCA2 SMARCA4	5.59e-06	3	48	2	17637742
Pubmed	BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.	SMARCA2 SMARCA4	5.59e-06	3	48	2	20571081
Pubmed	Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.	SMARCA2 SMARCA4	5.59e-06	3	48	2	14603256
Pubmed	ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.	SMARCA4 ATM	5.59e-06	3	48	2	24413084
Pubmed	SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†.	SMARCA2 SMARCA4	5.59e-06	3	48	2	36440965
Pubmed	Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2.	SMARCA2 SMARCA4	5.59e-06	3	48	2	9099865
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	RAD52 MSH3 ATM RB1CC1 HSD17B4 IL17RB	8.69e-06	351	48	6	20453000
Pubmed	Molecular cloning of a mouse scavenger receptor with C-type lectin (SRCL)(1), a novel member of the scavenger receptor family.	TGIF2LX TGIF2LY	1.12e-05	4	48	2	11718900
Pubmed	Dual role of NRSF/REST in activation and repression of the glucocorticoid response.	SMARCA2 SMARCA4	1.12e-05	4	48	2	17984088
Pubmed	Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma.	SMARCA2 SMARCA4	1.12e-05	4	48	2	31906887
Pubmed	Functional specificities of Brm and Brg-1 Swi/Snf ATPases in the feedback regulation of hepatic bile acid biosynthesis.	SMARCA2 SMARCA4	1.12e-05	4	48	2	19805516
Pubmed	SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice.	SMARCA2 SMARCA4	1.12e-05	4	48	2	25904594
Pubmed	BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development.	SMARCA2 SMARCA4	1.12e-05	4	48	2	11231080
Pubmed	BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.	SMARCA2 SMARCA4	1.12e-05	4	48	2	15141164
Pubmed	BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes.	SMARCA2 SMARCA4	1.12e-05	4	48	2	23897427
Pubmed	BRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.	SMARCA4 RAD52	1.12e-05	4	48	2	25395584
Pubmed	Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.	SMARCA2 SMARCA4	1.12e-05	4	48	2	19781646
Pubmed	Brahma safeguards canalization of cardiac mesoderm differentiation.	SMARCA2 SMARCA4	1.12e-05	4	48	2	35082446
Pubmed	Radiation-induced assembly of Rad51 and Rad52 recombination complex requires ATM and c-Abl.	RAD52 ATM	1.12e-05	4	48	2	10212258
Pubmed	Regulation of ATM and ATR by SMARCAL1 and BRG1.	SMARCA4 ATM	1.12e-05	4	48	2	30317028
Pubmed	BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.	SMARCA2 SMARCA4	1.12e-05	4	48	2	28232072
Pubmed	The clinicopathological significance of SWI/SNF alterations in gastric cancer is associated with the molecular subtypes.	SMARCA2 SMARCA4	1.12e-05	4	48	2	33481850
Pubmed	Mitotic inactivation of a human SWI/SNF chromatin remodeling complex.	SMARCA2 SMARCA4	1.12e-05	4	48	2	9744861
Pubmed	Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.	SMARCA2 SMARCA4	1.12e-05	4	48	2	24421395
Pubmed	Mammalian chromatin remodeling complex SWI/SNF is essential for enhanced expression of the albumin gene during liver development.	SMARCA2 SMARCA4	1.12e-05	4	48	2	16452305
Pubmed	Control of B cell development by the histone H2A deubiquitinase MYSM1.	SMARCA2 SMARCA4	1.12e-05	4	48	2	22169041
Pubmed	Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes.	SMARCA2 SMARCA4	1.86e-05	5	48	2	18487222
Pubmed	Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).	SMARCA2 SMARCA4	1.86e-05	5	48	2	9843504
Pubmed	The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.	SMARCA2 SMARCA4	1.86e-05	5	48	2	19342595
Pubmed	Expression pattern of TG-interacting factor 2 during mouse development.	TGIF2LX TGIF2LY	1.86e-05	5	48	2	15749073
Pubmed	Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors.	SMARCA2 SMARCA4	1.86e-05	5	48	2	12200431
Pubmed	Dynamic recruitment of functionally distinct Swi/Snf chromatin remodeling complexes modulates Pdx1 activity in islet β cells.	SMARCA2 SMARCA4	1.86e-05	5	48	2	25801033
Pubmed	Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression.	SMARCA2 SMARCA4	1.86e-05	5	48	2	20011120
Pubmed	Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth.	SMARCA2 SMARCA4	1.86e-05	5	48	2	12065415
Pubmed	A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes.	SMARCA2 SMARCA4	2.79e-05	6	48	2	10619021
Pubmed	Testing for association between MeCP2 and the brahma-associated SWI/SNF chromatin-remodeling complex.	SMARCA2 SMARCA4	2.79e-05	6	48	2	16940996
Pubmed	Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene.	SMARCA2 SMARCA4	2.79e-05	6	48	2	15347669
Interaction	NSD3 interactions	SMARCA2 SMARCA4 ATM RB1CC1 DOT1L	8.49e-06	117	48	5	int:NSD3
GeneFamily	TALE class homeoboxes and pseudogenes	TGIF2LX TGIF2LY	1.08e-03	26	34	2	526
Coexpression	HADDAD_B_LYMPHOCYTE_PROGENITOR	SMARCA4 RAD52 ATM RB1CC1 WASHC4 SPPL2B	1.45e-05	290	48	6	M939
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN	SMARCA2 CHD9 EIF3A	3.03e-05	33	48	3	M1359
Coexpression	GSE3982_BASOPHIL_VS_CENT_MEMORY_CD4_TCELL_UP	RB1CC1 WASHC4 HSD17B4 MILR1 RASGRP3	3.23e-05	200	48	5	M5559
Coexpression	SCHAEFFER_PROSTATE_DEVELOPMENT_AND_CANCER_BOX4_DN	SMARCA2 CHD9 EIF3A	4.29e-05	37	48	3	MM570
ToppCell	facs-Heart-LA-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 PIP5K1B SLC4A1 MYBPC3	2.99e-05	165	48	4	95866f7cc6eb1bb51a034a104a0eb2a53b0256f2
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 ROBO1 SLC14A2 SLC4A1	2.99e-05	165	48	4	c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 ROBO1 SLC14A2 SLC4A1	2.99e-05	165	48	4	4cdd80580d5638fd649280ba3893251c2f898f3f
ToppCell	facs-Heart-LA-18m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 PIP5K1B SLC4A1 MYBPC3	2.99e-05	165	48	4	f8bfe336b9a4460b9349c01acd0bd3167812662f
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3 SLC14A2 MYBPC3	5.20e-05	67	48	3	f117cec517d15bff2d4b963c5791877426272631
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Crispld2_(Neuron.Gad1Gad2.Synpr-Crispld2)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	C3 SLC14A2 MYBPC3	5.20e-05	67	48	3	df06046269894edbc872b48b9eccb458f6be8cf2
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ROBO1 PIP5K1B DNAH8 RASGRP3	5.29e-05	191	48	4	6a8b0987e75456a257954288206da0032605ff2a
ToppCell	droplet-Heart-nan-18m-Mesenchymal-cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 PIP5K1B MYBPC3 PDZRN4	5.40e-05	192	48	4	0bf99e029a06151092db1e8a0dcb45f4e688e771
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.40e-05	192	48	4	c8dcd75d695d09adff083af8d5a64cf15fe027d4
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.40e-05	192	48	4	e4dd24aefdf13cd4206714f02fde2288f3173ffc
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.40e-05	192	48	4	1a3f24607cb49aa610c183f4c2b7d735f484a3a4
ToppCell	droplet-Heart-nan-18m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK3 PIP5K1B MYBPC3 PDZRN4	5.40e-05	192	48	4	d766221acfce30cbf2c60b3ae40f6744968b952c
ToppCell	E18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.51e-05	193	48	4	f4dd52491254ce321bc4d0dad988a7ce5970f52d
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ATM GIMAP5 ENPP3 MCF2L2	5.51e-05	193	48	4	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	ROBO1 CHD9 C3 PDZRN4	5.62e-05	194	48	4	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.62e-05	194	48	4	9235849c7ef3236454eced413acff6274e991a0e
ToppCell	E16.5-Endothelial\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.62e-05	194	48	4	c048b7e08a08bb645a28c5b904bd87304d7a4f55
ToppCell	LV-02._Fibroblast_II\|LV / Chamber and Cluster_Paper	ROBO1 CHD9 C3 PDZRN4	5.62e-05	194	48	4	014d2feb5db2a6a35ef759761a41e466e108c3c1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.62e-05	194	48	4	7062b152367987aba12a2f6f653b647c74b4e160
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SMARCA2 DNAH8 GIMAP5 RASGRP3	5.62e-05	194	48	4	855ddaf1ec91e6fe1f1617900216a5742e96dda2
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PIP5K1B C3 OTULINL MILR1	5.97e-05	197	48	4	50f994e0d4e69019ec92e164edf3e4e951333766
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PIP5K1B C3 OTULINL MILR1	5.97e-05	197	48	4	769a4203c014b34d16d4d76d3caf07ddb2c41abc
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMARCA2 ATM ENPP3 MCF2L2	5.97e-05	197	48	4	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CDH23 C3 OTULINL DOT1L	6.20e-05	199	48	4	b0a906586e58009f5ed9272fc29ba28e49c85ee6
Computational	Neighborhood of RFC1	CHD9 ATM PEX3 BMS1	2.24e-04	109	30	4	MORF_RFC1
Disease	Hereditary Non-Polyposis Colon Cancer Type 2	SMARCA4 MSH3 ATM	3.38e-06	19	46	3	C1333991
Disease	Colorectal cancer, hereditary nonpolyposis, type 1	SMARCA4 MSH3 ATM	3.38e-06	19	46	3	C2936783
Disease	Hereditary Nonpolyposis Colorectal Neoplasms	SMARCA4 MSH3 ATM	8.99e-06	26	46	3	C0009405
Disease	Hereditary non-polyposis colorectal cancer syndrome	SMARCA4 MSH3 ATM	1.01e-05	27	46	3	C1112155
Disease	Hereditary Nonpolyposis Colorectal Cancer	SMARCA4 MSH3 ATM	1.26e-05	29	46	3	C1333990
Disease	Perrault syndrome (is_implicated_in)	HARS2 HSD17B4	2.37e-05	5	46	2	DOID:0050857 (is_implicated_in)
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	SMARCA2 SMARCA4	2.37e-05	5	46	2	C3281201
Disease	Perrault syndrome	HARS2 HSD17B4	3.55e-05	6	46	2	cv:C0685838
Disease	Gonadal dysgenesis XX type deafness	HARS2 HSD17B4	4.97e-05	7	46	2	C0685838
Disease	lung non-small cell carcinoma (is_implicated_in)	SMARCA4 RAD52 MSH3 ATM	6.60e-05	139	46	4	DOID:3908 (is_implicated_in)
Disease	renal tubular acidosis (implicated_via_orthology)	ATP6V0A1 SLC4A1	6.62e-05	8	46	2	DOID:14219 (implicated_via_orthology)
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCA2 SMARCA4	8.50e-05	9	46	2	DOID:0050340 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (is_implicated_in)	ALPK3 MYBPC3	8.50e-05	9	46	2	DOID:0080326 (is_implicated_in)
Disease	Zellweger Spectrum	HSD17B4 PEX3	1.83e-04	13	46	2	C3658299
Disease	Coffin-Siris syndrome	SMARCA2 SMARCA4	1.83e-04	13	46	2	C0265338
Disease	Zellweger-Like Syndrome	HSD17B4 PEX3	1.83e-04	13	46	2	C0751594
Disease	Adrenoleukodystrophy, Neonatal	HSD17B4 PEX3	2.46e-04	15	46	2	C0282525
Disease	Zellweger Syndrome	HSD17B4 PEX3	2.81e-04	16	46	2	C0043459
Disease	leukemia (implicated_via_orthology)	ATM DOT1L	4.00e-04	19	46	2	DOID:1240 (implicated_via_orthology)
Disease	BREAST CANCER	ATM RB1CC1	4.90e-04	21	46	2	114480
Disease	Immunologic Deficiency Syndromes	C3 ATM	5.89e-04	23	46	2	C0021051
Disease	lung squamous cell carcinoma (is_implicated_in)	RAD52 ATM	6.42e-04	24	46	2	DOID:3907 (is_implicated_in)
Disease	cancer (implicated_via_orthology)	SMARCA2 SMARCA4 PIP5K1B ATM	8.05e-04	268	46	4	DOID:162 (implicated_via_orthology)
Disease	Malignant tumor of breast	ATM RB1CC1	8.14e-04	27	46	2	cv:C0006142
Disease	Breast neoplasm	ATM RB1CC1	8.14e-04	27	46	2	cv:C1458155
Disease	Familial cancer of breast	ATM RB1CC1	8.14e-04	27	46	2	cv:C0346153
Disease	lung small cell carcinoma (is_implicated_in)	RAD52 ATM	8.76e-04	28	46	2	DOID:5409 (is_implicated_in)
Disease	nicotine use, generational effect measurement, illegal drug consumption, non-substance related disinhibited behaviour, alcohol drinking, alcohol dependence	WDR64 ZNF827	9.40e-04	29	46	2	EFO_0004329, EFO_0005430, EFO_0005431, EFO_0005432, EFO_0008364, MONDO_0007079
Disease	refractive error, self reported educational attainment	GABRR1 SLC14A2	1.29e-03	34	46	2	EFO_0004784, MONDO_0004892
Disease	endometrial cancer (is_implicated_in)	MSH3 ATM	1.45e-03	36	46	2	DOID:1380 (is_implicated_in)
Disease	human immunodeficiency virus infectious disease (is_marker_for)	C3 ATM	1.45e-03	36	46	2	DOID:526 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
DVPYVKRVKTWRMHL	SLC4A1	821	P02730
EYKIHQRWFAKLKRK	ALPK3	376	Q96L96
REALKLEEKKHYLMW	C3	1591	P01024
LWNTKDKMSRKVRYY	CFAP92	191	Q9ULG3
MKWYGKKHAEYTLER	DOT1L	206	Q8TEK3
YVQMRLKKHRWYKKI	BMS1	921	Q14692
MNWYYRTVHKRKLKA	CDH23	3086	Q9H251
WFEYRKRTFKHLKEK	CENPP	176	Q6IPU0
KMGRYWSKEERKQHL	PDZRN4	936	Q6ZMN7
WESHRKSQDMKKRKY	RAD52	401	P43351
RKMFIKHYREWAGAL	RB1CC1	506	Q8TDY2
RKRLKYFAKLWTMHN	MSH3	1101	P20585
KQKEKIELMRTFFHW	POC5	241	Q8NA72
IHAKFTDWKGYLMKR	L3MBTL2	286	Q969R5
VAGIYLMWRHERIKK	IL17RB	306	Q9NRM6
PFSVWTIHKDRYKMK	MCF2L2	846	Q86YR7
KMGRYWSKEERKQHL	PDZD4	671	Q76G19
MLRSVWNFLKRHKKK	PEX3	1	P56589
RLMKKLEHSWKALVY	PIP5K1B	356	O14986
LEHWKRMSAKFNYII	DNAH8	176	Q96JB1
FWVLPKYKTRKAMRN	MILR1	246	Q7Z6M3
NKLMRKAYEELFWRH	OTULINL	111	Q9NUU6
NWAYKALLRVKHLML	GIMAP5	266	Q96F15
WHLTKERKYIFSVRM	ATM	1026	Q13315
WTKFRAMARLHKKTD	CHD9	1866	Q3L8U1
KKIWVPDMFFVHSKR	GABRR1	151	P24046
LYDVMKSKKHRTWQK	EIF3A	31	Q14152
FRKMWDYFHSVLLIK	ENPP3	721	O14638
TRAAWEHMKKQKYGR	HSD17B4	131	P51659
LDTKVHLKDLKFYWM	FAAH2	296	Q6GMR7
ALHWKKVYLKAILRM	FBXW2	116	Q9UKT8
EVRWRMRKLKYKHLA	TBRG4	171	Q969Z0
RRQIKYSKDKMWYLA	MRPL22	71	Q9NWU5
SVKILRDWMYKHRFK	TGIF2LX	61	Q8IUE1
KKMKRYHVGKVWRRE	HARS2	146	P49590
SVKILRDWMYKHRFK	TGIF2LY	61	Q8IUE0
DKHILAKIRWKYMIV	SMARCA2	836	P51531
YDWMRRVTQRKKVSK	RASGRP3	126	Q8IV61
DKHILAKIRWKYMIV	SMARCA4	866	P51532
KLTARKYREWKVMNT	CNK3/IPCEF1	846	G9CGD6
YWAGSRDVKKRYMKH	SPPL2B	191	Q8TCT7
LMVFSIWLYRHRKKR	ROBO1	911	Q9Y6N7
LVIKRKSYWKRHMVI	ZNF827	381	Q17R98
RVWFIKVRKMKAIYH	ATP6V0A1	291	Q93050
ITLKDHWTMYKRLLK	WASHC4	211	Q2M389
DMKEYRIWLKDKHLA	SLC14A2	101	Q15849
SYMEKLWLKKHRRTP	ZBBX	316	A8MT70
VKRKLHNDWVMKIRY	WDR64	271	B1ANS9
YILERKKKKSYRWMR	MYBPC3	806	Q14896