Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	mitotic sister chromatid cohesion, centromeric	CDK11A CDK11B	4.57e-05	7	31	2	GO:0071962
Domain	BRCT	TOPBP1 XRCC1	5.08e-04	19	33	2	PF00533
Domain	BRCT	TOPBP1 XRCC1	6.84e-04	22	33	2	SM00292
Domain	-	TOPBP1 XRCC1	7.48e-04	23	33	2	3.40.50.10190
Domain	BRCT	TOPBP1 XRCC1	9.58e-04	26	33	2	PS50172
Domain	BRCT_dom	TOPBP1 XRCC1	1.11e-03	28	33	2	IPR001357
Domain	-	PITPNM2 ATP8B1	5.70e-03	64	33	2	3.40.50.1000
Domain	-	XRCC1 F5	7.36e-03	73	33	2	2.60.120.260
Domain	HAD-like_dom	PITPNM2 ATP8B1	8.57e-03	79	33	2	IPR023214
Domain	Galactose-bd-like	XRCC1 F5	1.20e-02	94	33	2	IPR008979
Pathway	BIOCARTA_HIVNEF_PATHWAY	CDK11A CDK11B SPTAN1	9.94e-05	56	23	3	MM1406
Pathway	BIOCARTA_HIVNEF_PATHWAY	CDK11A CDK11B SPTAN1	9.94e-05	56	23	3	M13968
Pathway	REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES	CDK11A SFI1 CDK11B	2.98e-04	81	23	3	M748
Pubmed	Regulated expression of a cell division control-related protein kinase during development.	CDK11A CDK11B	1.04e-06	2	36	2	2069872
Pubmed	A cyclin-dependent kinase homologue, p130PITSLRE is a phosphotyrosine-independent SH2 ligand.	CDK11A CDK11B	1.04e-06	2	36	2	7528743
Pubmed	Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15.	CDK11A CDK11B	1.04e-06	2	36	2	1774066
Pubmed	Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.	CDK11A CDK11B	1.04e-06	2	36	2	8195233
Pubmed	CDK11p58 Promotes Microglia Activation via Inducing Cyclin D3 Nuclear Localization.	CDK11A CDK11B	1.04e-06	2	36	2	28101846
Pubmed	CDK11p110 plays a critical role in the tumorigenicity of esophageal squamous cell carcinoma cells and is a potential drug target.	CDK11A CDK11B	1.04e-06	2	36	2	30722725
Pubmed	Identification and characterization of a novel cell cycle-regulated internal ribosome entry site.	CDK11A CDK11B	1.04e-06	2	36	2	10882096
Pubmed	The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer.	CDK11A CDK11B	1.04e-06	2	36	2	27049727
Pubmed	Structure and expression of the human p58clk-1 protein kinase chromosomal gene.	CDK11A CDK11B	1.04e-06	2	36	2	1639388
Pubmed	Protein expression pattern of CDK11(p58) during testicular development in the mouse.	CDK11A CDK11B	1.04e-06	2	36	2	15792358
Pubmed	Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development.	CDK11A CDK11B	1.04e-06	2	36	2	15060143
Pubmed	Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.	CDK11A CDK11B	1.04e-06	2	36	2	7920654
Pubmed	Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.	CDK11A CDK11B	3.12e-06	3	36	2	17389615
Pubmed	Repression of estrogen receptor alpha by CDK11p58 through promoting its ubiquitin-proteasome degradation.	CDK11A CDK11B	3.12e-06	3	36	2	19122208
Pubmed	The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo.	CDK11A CDK11B	3.12e-06	3	36	2	9580558
Pubmed	The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.	CDK11A CDK11B	3.12e-06	3	36	2	12624090
Pubmed	APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.	APLP2 PRC1	3.12e-06	3	36	2	27796194
Pubmed	CDK11 Promotes Cytokine-Induced Apoptosis in Pancreatic Beta Cells Independently of Glucose Concentration and Is Regulated by Inflammation in the NOD Mouse Model.	CDK11A CDK11B	3.12e-06	3	36	2	33664748
Pubmed	The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM.	CDK11A CDK11B	3.12e-06	3	36	2	14511641
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CEP350 TOPBP1 CDK11A XRCC1 PRC1 F5 SPTAN1	3.82e-06	645	36	7	25281560
Pubmed	Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.	CDK11A CDK11B	6.24e-06	4	36	2	2217177
Pubmed	CDK11 complexes promote pre-mRNA splicing.	CDK11A CDK11B	6.24e-06	4	36	2	12501247
Pubmed	CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.	CDK11A CDK11B	6.24e-06	4	36	2	24436071
Pubmed	Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2.	CDK11A CDK11B	6.24e-06	4	36	2	9750192
Pubmed	A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.	CDK11A CDK11B	6.24e-06	4	36	2	7777541
Pubmed	Cyclin D3/CDK11p58 complex is involved in the repression of androgen receptor.	CDK11A CDK11B	6.24e-06	4	36	2	17698582
Pubmed	Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor.	CDK11A CDK11B	6.24e-06	4	36	2	9115219
Pubmed	Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha.	CDK11A CDK11B	6.24e-06	4	36	2	15330758
Pubmed	CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.	CDK11A CDK11B	1.04e-05	5	36	2	17516030
Pubmed	Riz maps to distal chromosome 4 near genes involved in tumorigenesis and nerve degeneration.	CDK11A CDK11B	1.04e-05	5	36	2	8679000
Pubmed	Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death.	CDK11A CDK11B	1.04e-05	5	36	2	9632733
Pubmed	The gene for mouse p58cdc2L1 (Cdc2l1) protein kinase maps to distal mouse chromosome 4.	CDK11A CDK11B	1.04e-05	5	36	2	8199413
Pubmed	Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.	CDK11A CDK11B	1.56e-05	6	36	2	19245811
Pubmed	Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity.	CDK11A CDK11B	1.56e-05	6	36	2	15963510
Pubmed	The cyclin-dependent kinase 11 interacts with 14-3-3 proteins.	CDK11A CDK11B	2.18e-05	7	36	2	15883043
Pubmed	Genomic organization and genetic mapping of the neuroimmune gene I2rf5 to mouse chromosome 4.	CDK11A CDK11B	2.91e-05	8	36	2	7774930
Pubmed	FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.	CDK11A CDK11B	2.91e-05	8	36	2	22024926
Pubmed	Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors.	CDK11A CDK11B	3.73e-05	9	36	2	14623875
Pubmed	UbE2E1/UBCH6 Is a Critical in Vivo E2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119.	UBE2E1 PRC1	5.70e-05	11	36	2	28073915
Pubmed	Cyclin-dependent kinases: a family portrait.	CDK11A CDK11B	6.83e-05	12	36	2	19884882
Pubmed	The protein interaction landscape of the human CMGC kinase group.	CEP350 CDK11A DGCR8 WDR6 PHF3 SPTAN1	7.28e-05	695	36	6	23602568
Pubmed	Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.	CDK11A CDK11B	1.08e-04	15	36	2	18827223
Pubmed	A human MAP kinase interactome.	CEP350 APLP2 CGNL1 SPTAN1 MCM3AP	1.38e-04	486	36	5	20936779
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TOPBP1 TBRG4 CDK11B PRC1 PHF3	1.62e-04	503	36	5	16964243
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SFI1 CCDC144A MCM3AP	1.78e-04	105	36	3	9628581
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	CDK11A CDK11B XRCC1 PHF3	2.06e-04	283	36	4	30585729
Pubmed	The Role of CDKs and CDKIs in Murine Development.	CDK11A CDK11B	2.16e-04	21	36	2	32731332
Pubmed	Positional cloning of the mouse saccharin preference (Sac) locus.	CDK11A CDK11B	2.38e-04	22	36	2	11555487
Pubmed	Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.	TOPBP1 XRCC1	2.83e-04	24	36	2	22522401
Pubmed	NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy.	SPTAN1 MYO5C	3.08e-04	25	36	2	30309841
Pubmed	Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV.	CDK11B XRCC1	3.08e-04	25	36	2	15385968
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	TOPBP1 CDK11A CDK11B CGNL1 MCM3AP	3.32e-04	588	36	5	38580884
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	CDK11A CDK11B XRCC1 PRC1 SPTAN1 MYO5C	3.93e-04	949	36	6	36574265
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TOPBP1 CDK11A DGCR8 CDK11B XRCC1 PHF3	4.04e-04	954	36	6	36373674
Pubmed	Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).	CDK11B WDR6	4.75e-04	31	36	2	26678539
Pubmed	Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages.	CDK11A CDK11B	5.07e-04	32	36	2	26142281
Pubmed	Association of mitotic regulation pathway polymorphisms with pancreatic cancer risk and outcome.	TOPBP1 PRC1	5.07e-04	32	36	2	20056645
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	CDK11A XRCC1 PRC1 F5 SPTAN1	5.62e-04	660	36	5	32780723
Pubmed	Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.	CRYBB1 APLP2 SPTAN1	5.67e-04	156	36	3	29961565
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	TOPBP1 CDK11A CDK11B PHF3	5.67e-04	370	36	4	22922362
Pubmed	Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.	CDK11A CDK11B	6.42e-04	36	36	2	9457670
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	TOPBP1 NDUFA13 CDK11A APLP2 DGCR8 XRCC1 PHF3	7.52e-04	1497	36	7	31527615
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CEP350 PRC1 WDR6 PHF3 SPTAN1	8.52e-04	724	36	5	36232890
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CEP350 CDK11B XRCC1 WDR6 PHF3	9.00e-04	733	36	5	34672954
Interaction	SPDEF interactions	CDK11A CDK11B PRC1 MYO5C	7.48e-07	40	36	4	int:SPDEF
GeneFamily	Cyclin dependent kinases	CDK11A CDK11B	4.51e-04	26	22	2	496
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	CEP350 NDUFA13 ANKRD62 TBRG4 WDR6 TCEAL9	1.14e-08	197	36	6	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PITPNM2 F5 TCEAL9 SPTAN1	3.65e-06	130	36	4	0f9d3e6297f48ae14d24ac997d8d3a94f337d4d4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_2\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PITPNM2 F5 TCEAL9 SPTAN1	3.65e-06	130	36	4	fc68a648161dd314d9ee6612fd039cb12171b8c6
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBB1 NDUFA13 MLXIPL PRC1	1.35e-05	181	36	4	9fce5eee75684a7ecac6996e26e9215bc95098b2
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBB1 NDUFA13 MLXIPL PRC1	1.35e-05	181	36	4	ad97e802e934738ddece675232a72308db2da256
Disease	Tourette syndrome, schizophrenia	PITPNM2 PHF3	1.72e-04	18	32	2	EFO_0004895, MONDO_0005090
Disease	liver cirrhosis (is_implicated_in)	XRCC1 F5	1.00e-03	43	32	2	DOID:5082 (is_implicated_in)
Disease	triacylglycerol 52:2 measurement	CRYBB1 MLXIPL	1.63e-03	55	32	2	EFO_0010414
Disease	hemoglobin A1 measurement	MLXIPL PRC1 TRIM58 MYO5C	2.32e-03	520	32	4	EFO_0007629
Disease	Dermatologic disorders	UBE2E1 GOLGA6L7	3.01e-03	75	32	2	C0037274

Protein segments in the cluster

Peptide	Gene	Start	Entry
CRRRMATWRKNRDKD	ANKRD62	11	A6NC57
MQSLRRLRDKQWHLE	CRYBB1	226	P53674
REWERQKRREMAREH	CDK11B	146	P21127
WAERRQFNREMKRKQ	DGCR8	461	Q8WYQ5
HRKRLKAEEQWQRRQ	ATP8B1	1181	O43520
AHWLMRRRRRKQRKK	TP53I13	126	Q8NBR0
HRNRMDRVKKEWEEA	APLP2	401	Q06481
WREAVTARKKLRRQM	MCM3AP	1246	O60318
NRRMKWRNSKERELL	DBX1	231	A6NMT0
MKWNRERRRLQIEDF	NDUFA13	51	Q9P0J0
RKHEEKMWRQEQRLR	GOLGA6L7	251	A0A1B0GV03
KMWRQEQRLRDQEKE	GOLGA6L7	256	A0A1B0GV03
REKWQRKRTHVKLRN	PITPNM2	986	Q9BZ72
QLRRLKNEMENERWH	CGNL1	931	Q0VF96
MWKVRQRAQIQPRHR	REXO1L1P	651	Q8IX06
MQRRQHAEELLEWKR	CEP350	1866	Q5VT06
WERQKRREMAREHSR	CDK11A	136	Q9UQ88
QRTRQEWVRLHDKMK	CCDC144A	941	A2RUR9
QSVEQEVRWRMRKLK	TBRG4	166	Q969Z0
WRQKMFQHRENRLAE	SFI1	526	A8K8P3
LKKITREQRRHMKRW	F5	336	P12259
DRKLMQEKWLRDHKR	ODAD4	251	Q96NG3
WEMHRLEKERAKQER	PRC1	436	O43663
MRNHLNEKRALRLEW	RMND1	416	Q9NWS8
KRRIEVVMREYHKWR	MLXIPL	171	Q9NP71
CEQMWHREKRRQRNK	SEMA3D	731	O95025
DIWRVNIQRKRRQDM	ZNF793	81	Q6ZN11
RNEVLDRWRRLKAQM	SPTAN1	1526	Q13813
WRRRENRHTIEMIEK	PHF3	1026	Q92576
RRVRNKLIVMRWKVN	TCEAL9	81	Q9UHQ7
DEYWDRQRNRHRMVK	WDR6	841	Q9NNW5
VRKEWVLDCHRMRRR	XRCC1	381	P18887
NRAEHDRMARQWTKR	UBE2E1	176	P51965
QQRRLALAAMRWRKK	TOPBP1	1366	Q92547
WKEKVEMQRQRFRLE	TRIM58	171	Q8NG06
HLKGERARWQQRMRK	GOLGA8CP	236	A6NN73
HMRGWLQRKKFLRER	MYO5C	766	Q9NQX4