Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	parathyroid hormone receptor activity	PTH1R PTH2R	6.40e-06	2	51	2	GO:0004991
GeneOntologyMolecularFunction	peptide hormone binding	MC4R PTH1R PTH2R	3.75e-04	55	51	3	GO:0017046
GeneOntologyCellularComponent	GLI-SUFU complex	GLI1 GLI3	3.49e-05	4	51	2	GO:1990788
GeneOntologyCellularComponent	ciliary tip	IFT140 GLI1 GLI3	2.19e-04	48	51	3	GO:0097542
HumanPheno	Preductal coarctation of the aorta	GLI3 PTH1R	1.05e-05	2	17	2	HP:0005151
HumanPheno	Distal shortening of limbs	GLI3 PTH1R	3.14e-05	3	17	2	HP:0006402
HumanPheno	Coarctation of the descending aortic arch	GLI3 PTH1R	3.14e-05	3	17	2	HP:0012305
HumanPheno	Accelerated skeletal maturation	GLI3 MC4R HSD11B1 PTH1R	6.80e-05	70	17	4	HP:0005616
HumanPheno	Renal dysplasia	IFT140 ZNF148 GLI3 ITGB4	8.47e-05	74	17	4	HP:0000110
HumanPheno	Abnormal aortic morphology	IFT140 GJA8 ZNF148 AEBP1 GLI3 UBE3B PTH1R	9.16e-05	363	17	7	HP:0030963
HumanPheno	Coarctation of aorta	GJA8 ZNF148 GLI3 UBE3B PTH1R	9.63e-05	150	17	5	HP:0001680
HumanPheno	Abnormal aortic morphology	IFT140 GJA8 ZNF148 AEBP1 GLI3 UBE3B PTH1R	1.73e-04	401	17	7	HP:0001679
HumanPheno	Abnormality of the elbow	P4HTM AEBP1 GLI1 GLI3 L1CAM PTH1R	2.01e-04	282	17	6	HP:0009811
HumanPheno	Mesoaxial foot polydactyly	GJA8 GLI3	2.18e-04	7	17	2	HP:0010112
Domain	ZINC_FINGER_C2H2_2	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	1.89e-04	775	50	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	1.93e-04	777	50	9	PS00028
Domain	Znf_C2H2-like	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	2.31e-04	796	50	9	IPR015880
Domain	Znf_C2H2	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	2.51e-04	805	50	9	IPR007087
Domain	ZnF_C2H2	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	2.58e-04	808	50	9	SM00355
Domain	-	ZNF148 ZNF382 GLI1 GLI3 ZNF511 PRDM15 ZBTB1 ZNF548	4.07e-04	679	50	8	3.30.160.60
Domain	zf-C2H2	ZNF148 ZNF382 GLI1 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	4.66e-04	693	50	8	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF148 ZNF382 GLI1 GLI3 ZNF511 PRDM15 ZBTB1 ZNF548	4.71e-04	694	50	8	IPR013087
Domain	WD40_repeat_dom	IFT140 VPS11 DCAF10 UTP4 BRWD1	1.16e-03	297	50	5	IPR017986
Domain	-	IFT140 VPS11 DCAF10 UTP4 BRWD1	1.92e-03	333	50	5	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	IFT140 VPS11 DCAF10 UTP4 BRWD1	1.97e-03	335	50	5	IPR015943
Domain	HormR	PTH1R PTH2R	2.03e-03	25	50	2	SM00008
Domain	HRM	PTH1R PTH2R	2.54e-03	28	50	2	PF02793
Domain	GPCR_2_secretin-like_CS	PTH1R PTH2R	3.73e-03	34	50	2	IPR017983
Domain	WD40	IFT140 DCAF10 UTP4 BRWD1	5.05e-03	259	50	4	PF00400
Domain	G_PROTEIN_RECEP_F2_1	PTH1R PTH2R	5.13e-03	40	50	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	PTH1R PTH2R	5.13e-03	40	50	2	PS50227
Domain	GPCR_2_extracellular_dom	PTH1R PTH2R	5.13e-03	40	50	2	IPR001879
Domain	WD40	IFT140 DCAF10 UTP4 BRWD1	5.69e-03	268	50	4	SM00320
Domain	WD40_repeat	IFT140 DCAF10 UTP4 BRWD1	5.99e-03	272	50	4	IPR001680
Domain	WD_REPEATS_1	IFT140 DCAF10 UTP4 BRWD1	6.47e-03	278	50	4	PS00678
Domain	WD_REPEATS_2	IFT140 DCAF10 UTP4 BRWD1	6.55e-03	279	50	4	PS50082
Domain	WD_REPEATS_REGION	IFT140 DCAF10 UTP4 BRWD1	6.55e-03	279	50	4	PS50294
Pubmed	Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.	GLI1 GLI3 PTH1R	3.54e-07	10	51	3	16284117
Pubmed	Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia.	GLI1 GLI3 PTH1R	6.47e-07	12	51	3	17660199
Pubmed	Temporomandibular joint formation and condyle growth require Indian hedgehog signaling.	GLI1 GLI3 PTH1R	8.41e-07	13	51	3	17191253
Pubmed	Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.	IFT140 GLI1 GLI3	1.99e-06	17	51	3	23955340
Pubmed	Long bone development requires a threshold of Hox function.	GLI1 GLI3 PTH1R	1.99e-06	17	51	3	24930703
Pubmed	Protein phosphatase 2A and rapamycin regulate the nuclear localization and activity of the transcription factor GLI3.	GLI1 GLI3	2.11e-06	2	51	2	18559511
Pubmed	Molecular cloning and expression pattern of a Cubitus interruptus homologue from the mulberry silkworm Bombyx mori.	GLI1 GLI3	2.11e-06	2	51	2	12351188
Pubmed	A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome.	GLI1 GLI3	2.11e-06	2	51	2	21921029
Pubmed	PTH-receptors regulate norepinephrine release in human heart and kidney.	PTH1R PTH2R	2.11e-06	2	51	2	21756942
Pubmed	Lack of association of TNFAIP3 and JAK1 with Behçet's disease in the European population.	JAK1 TNFAIP3	2.11e-06	2	51	2	26005883
Pubmed	Parathyroid hormone stimulates juxtaglomerular cell cAMP accumulation without stimulating renin release.	PTH1R PTH2R	2.11e-06	2	51	2	22896038
Pubmed	Expression of the GLI family genes is associated with tumor progression in advanced lung adenocarcinoma.	GLI1 GLI3	2.11e-06	2	51	2	25103784
Pubmed	Palmar and plantar pads and flexion creases of genetic polydactyly mice (Pdn).	GLI1 GLI3	2.11e-06	2	51	2	9918099
Pubmed	Gli3 is a Key Factor in the Schwann Cells from Both Intact and Injured Peripheral Nerves.	GLI1 GLI3	2.11e-06	2	51	2	32114096
Pubmed	Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.	GLI1 GLI3	2.11e-06	2	51	2	10693759
Pubmed	Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.	PTH1R PTH2R	2.11e-06	2	51	2	18539702
Pubmed	Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation.	GLI1 PTH1R	2.11e-06	2	51	2	32039485
Pubmed	gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development.	GLI1 GLI3	2.11e-06	2	51	2	8364225
Pubmed	Ofd1 is required in limb bud patterning and endochondral bone development.	GLI1 GLI3 PTH1R	2.39e-06	18	51	3	20920500
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	WAPL ZNF148 UTP4 MORC3 ZNF512 PRDM15 DNTTIP1 BRWD1	2.74e-06	608	51	8	36089195
Pubmed	Sonic hedgehog regulates growth and morphogenesis of the tooth.	GLI1 GLI3 L1CAM	3.88e-06	21	51	3	11044393
Pubmed	Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome.	GLI1 GLI3 PTH1R	3.88e-06	21	51	3	14745966
Pubmed	Gli3 is required in Emx1+ progenitors for the development of the corpus callosum.	GLI1 GLI3 L1CAM	3.88e-06	21	51	3	23396189
Pubmed	ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.	IFT140 GLI1 GLI3	4.49e-06	22	51	3	25294941
Pubmed	FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton.	GLI1 GLI3 PTH1R	5.88e-06	24	51	3	39012257
Pubmed	Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.	GLI1 GLI3	6.32e-06	3	51	2	24311597
Pubmed	Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes.	GLI1 GLI3	6.32e-06	3	51	2	26010061
Pubmed	Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3.	GLI1 GLI3	6.32e-06	3	51	2	10075717
Pubmed	A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene.	GLI1 GLI3	6.32e-06	3	51	2	8387379
Pubmed	Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.	GLI1 GLI3	6.32e-06	3	51	2	16571352
Pubmed	The SHH/Gli axis regulates CD90-mediated liver cancer stem cell function by activating the IL6/JAK2 pathway.	GLI1 GLI3	6.32e-06	3	51	2	29722127
Pubmed	Different expression patterns of Gli1-3 in mouse embryonic maxillofacial development.	GLI1 GLI3	6.32e-06	3	51	2	22178118
Pubmed	Brachyphalangy, an allele of extra-toes in the mouse.	GLI1 GLI3	6.32e-06	3	51	2	5806166
Pubmed	Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.	GLI1 GLI3	6.32e-06	3	51	2	28965847
Pubmed	Gli family members are differentially expressed during the mitotic phase of spermatogenesis.	GLI1 GLI3	6.32e-06	3	51	2	9178901
Pubmed	Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.	GLI1 GLI3	6.32e-06	3	51	2	8378770
Pubmed	The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development.	GLI1 GLI3 L1CAM	6.68e-06	25	51	3	22479201
Pubmed	Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.	IFT140 GLI1 GLI3	6.68e-06	25	51	3	27340223
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	JAK1 KCNH7 FBL GLI3 UBE3B DNTTIP1	8.92e-06	331	51	6	19490893
Pubmed	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.	IFT140 GLI1 GLI3	1.06e-05	29	51	3	21209331
Pubmed	Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15.	SOX21 GLI1 GLI3	1.17e-05	30	51	3	28560839
Pubmed	Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.	GLI1 GLI3	1.26e-05	4	51	2	9027508
Pubmed	Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.	GLI1 GLI3	1.26e-05	4	51	2	22281533
Pubmed	Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development.	GLI1 GLI3	1.26e-05	4	51	2	9006072
Pubmed	Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.	GLI1 GLI3	1.26e-05	4	51	2	27793025
Pubmed	Expression profile of Gli family members and Shh in normal and mutant mouse limb development.	GLI1 GLI3	1.26e-05	4	51	2	9438426
Pubmed	Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm- and mesoderm-derived tissues suggests multiple roles during postimplantation development.	GLI1 GLI3	1.26e-05	4	51	2	8150204
Pubmed	Genetic variation in the PTH pathway and bone phenotypes in elderly women: evaluation of PTH, PTHLH, PTHR1 and PTHR2 genes.	PTH1R PTH2R	1.26e-05	4	51	2	18280230
Pubmed	Anorectal malformations caused by defects in sonic hedgehog signaling.	GLI1 GLI3	1.26e-05	4	51	2	11485934
Pubmed	Gene polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis.	MC4R TNFAIP3	1.26e-05	4	51	2	29696068
Pubmed	Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.	GLI1 GLI3	1.26e-05	4	51	2	10531011
Pubmed	SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.	GLI1 GLI3	2.10e-05	5	51	2	20711444
Pubmed	Functional compensation in Hedgehog signaling during mouse prostate development.	GLI1 GLI3	2.10e-05	5	51	2	16707121
Pubmed	Genomic organization, chromosomal assignment, and expression analysis of the mouse suppressor of fused gene (Sufu) coding a Gli protein partner.	GLI1 GLI3	2.10e-05	5	51	2	10920228
Pubmed	A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.	GLI1 GLI3	2.10e-05	5	51	2	9118802
Pubmed	Evidence for the involvement of the Gli gene family in embryonic mouse lung development.	GLI1 GLI3	2.10e-05	5	51	2	9268579
Pubmed	Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.	GLI1 GLI3	2.10e-05	5	51	2	24218555
Pubmed	Gli regulation by the opposing activities of fused and suppressor of fused.	GLI1 GLI3	2.10e-05	5	51	2	10806483
Pubmed	p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.	GLI1 GLI3	2.10e-05	5	51	2	26282181
Pubmed	Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.	GLI1 GLI3	2.10e-05	5	51	2	9216996
Pubmed	Expression of the mouse Fgf15 gene is directly initiated by Sonic hedgehog signaling in the diencephalon and midbrain.	GLI1 GLI3	2.10e-05	5	51	2	15614767
Pubmed	Extra-toes (Xt) homozygous mutant mice demonstrate a role for the Gli-3 gene in the development of the forebrain.	GLI3 L1CAM	2.10e-05	5	51	2	7976186
Pubmed	Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3.	GLI1 GLI3	2.10e-05	5	51	2	19996099
Pubmed	Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse.	GLI1 GLI3	2.10e-05	5	51	2	10096602
Pubmed	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation.	GLI1 GLI3	2.10e-05	5	51	2	16611981
Pubmed	Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.	GLI1 GLI3	2.10e-05	5	51	2	15315762
Pubmed	A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud.	GLI1 GLI3	2.10e-05	5	51	2	24700818
Pubmed	Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli.	GLI1 GLI3	2.10e-05	5	51	2	10564661
Pubmed	Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma.	GLI1 GLI3	2.10e-05	5	51	2	19593328
Pubmed	NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.	FBL UTP4	2.10e-05	5	51	2	22916032
Pubmed	Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.	GLI1 GLI3	2.10e-05	5	51	2	26120032
Pubmed	Expression pattern of Irx1 and Irx2 during mouse digit development.	GLI1 GLI3	2.10e-05	5	51	2	11472848
Pubmed	Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis.	GLI1 GLI3 PTH1R	2.42e-05	38	51	3	16818445
Pubmed	Cell cycle-related kinase is a crucial regulator for ciliogenesis and Hedgehog signaling in embryonic mouse lung development.	IFT140 GLI1 GLI3	2.82e-05	40	51	3	32317081
Pubmed	Nerve-derived sonic hedgehog defines a niche for hair follicle stem cells capable of becoming epidermal stem cells.	GLI1 GLI3	3.15e-05	6	51	2	21549329
Pubmed	Pleiotropy in FOXC1-attributable phenotypes involves altered ciliation and cilia-dependent signaling.	GLI1 GLI3	3.15e-05	6	51	2	39217245
Pubmed	RNF220-mediated ubiquitination promotes aggresomal accumulation and autophagic degradation of cytoplasmic Gli via HDAC6.	GLI1 GLI3	3.15e-05	6	51	2	33895473
Pubmed	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.	GLI1 GLI3	3.15e-05	6	51	2	14681189
Pubmed	Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia.	GLI1 GLI3	3.15e-05	6	51	2	19536807
Pubmed	A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.	GLI1 GLI3	3.15e-05	6	51	2	12385751
Pubmed	Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.	GLI1 GLI3	3.15e-05	6	51	2	31279575
Pubmed	Physical and functional interactions between Zic and Gli proteins.	GLI1 GLI3	3.15e-05	6	51	2	11238441
Pubmed	Expression of sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium.	GLI1 GLI3	3.15e-05	6	51	2	19432668
Pubmed	Titration of GLI3 repressor activity by sonic hedgehog signaling is critical for maintaining multiple adult neural stem cell and astrocyte functions.	GLI1 GLI3	3.15e-05	6	51	2	24174682
Pubmed	Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.	GLI1 GLI3	3.15e-05	6	51	2	34423857
Pubmed	The Pluripotency Factor NANOG Binds to GLI Proteins and Represses Hedgehog-mediated Transcription.	GLI1 GLI3	3.15e-05	6	51	2	26797124
Pubmed	Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.	GLI1 GLI3	3.15e-05	6	51	2	17202190
Pubmed	Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.	GLI1 GLI3	3.15e-05	6	51	2	16254602
Pubmed	Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.	GLI1 GLI3	3.15e-05	6	51	2	21209912
Pubmed	Genetic analysis of Hedgehog signaling in ventral body wall development and the onset of omphalocele formation.	GLI1 GLI3	3.15e-05	6	51	2	21283718
Pubmed	Irx1 and Irx2 expression in early lung development.	GLI1 GLI3	3.15e-05	6	51	2	11472847
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	JAK1 IFT140 WAPL ZNF148 FBL GLI3 HSD11B1 TUBGCP5 BRWD1	3.16e-05	1116	51	9	31753913
Pubmed	Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice.	GLI1 GLI3	4.41e-05	7	51	2	9152005
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	GLI1 GLI3	4.41e-05	7	51	2	21653639
Pubmed	Analysis of the Sonic Hedgehog signaling pathway in normal and abnormal bladder development.	GLI1 GLI3	4.41e-05	7	51	2	23308271
Pubmed	Sonic hedgehog regulates discrete populations of astrocytes in the adult mouse forebrain.	GLI1 GLI3	4.41e-05	7	51	2	20943901
Pubmed	Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.	GLI1 GLI3	4.41e-05	7	51	2	23201751
Pubmed	FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine.	GLI1 GLI3	4.41e-05	7	51	2	19049965
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	GLI1 GLI3	4.41e-05	7	51	2	38261656
Pubmed	Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus.	GLI1 GLI3	4.41e-05	7	51	2	14568100
Cytoband	7p13	AEBP1 GLI3	8.73e-04	39	51	2	7p13
Cytoband	1q23.3	CCDC190 ARHGAP30	1.38e-03	49	51	2	1q23.3
GeneFamily	Parathyroid hormone receptors	PTH1R PTH2R	4.77e-06	2	40	2	270
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF148 ZNF382 GLI1 GLI3 ZNF511 ZNF512 PRDM15 ZBTB1 ZNF548	2.11e-05	718	40	9	28
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF10 BRWD1	7.14e-04	18	40	2	498
GeneFamily	WD repeat domain containing	IFT140 DCAF10 UTP4 BRWD1	2.61e-03	262	40	4	362
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI3 GPR173 CCDC190 HSD11B1 PTH1R	8.06e-08	190	51	6	8cb950effc449ae59a915132ecc079be54d1acfe
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI3 GPR173 CCDC190 HSD11B1 PTH1R	8.06e-08	190	51	6	17a73a658fb30a4322b31e38db7b240023738f29
ToppCell	droplet-Pancreas-Exocrine-24m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI3 GPR173 CCDC190 HSD11B1 PTH1R	8.06e-08	190	51	6	5dfbd064ab1f8a0b18b5975c47f8e79697f3db15
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 AGMO PTH1R	2.76e-06	193	51	5	03678162648bd5b1d65a5450b60c8863edbf95c7
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 AGMO PTH1R	2.76e-06	193	51	5	59b8186d0221fba06a16157e9d148399ed801f38
ToppCell	droplet-Pancreas-Endocrine-21m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 AGMO PTH1R	2.76e-06	193	51	5	dc92680b4bb9fc26430c92e03adb839c8c3b3b98
ToppCell	CV-Severe-0\|Severe / Virus stimulation, Condition and Cluster	JAK1 L1CAM RASGEF1B TNFAIP3 ZBTB1	3.05e-06	197	51	5	d13fc20b31ab6d9117437fba319c72f3a552858f
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D122\|Adult / Lineage, Cell type, age group and donor	AEBP1 GLI1 GLI3 PTH1R	3.22e-05	158	51	4	410fa08c9d880d27e80ec939fa5ba5a41dcb31ab
ToppCell	droplet-Heart-HEART_(LV+RV_ONLY)-30m-Hematologic-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE7A L1CAM ARHGAP30 HSD11B1	4.18e-05	169	51	4	15a9183c838cc6384d7f5dfeae3d30602964c9b3
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI3 HSD11B1 PTH1R	4.18e-05	169	51	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX21 AEBP1 GLI3 ITGB4	5.12e-05	178	51	4	4813d6509738f088c12ebf395b70d496af04649a
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI1 GLI3 CCDC190 HSD11B1	5.70e-05	183	51	4	99bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX21 AEBP1 GLI3 ITGB4	6.07e-05	186	51	4	73cf266aeecd3cc15e8cb6094588a393bca8fbe6
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 HSD11B1	6.20e-05	187	51	4	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 HSD11B1	6.20e-05	187	51	4	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 GLI1 GLI3 HSD11B1	6.20e-05	187	51	4	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE7A AGMO PTH1R PTH2R	6.20e-05	187	51	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDE7A AGMO PTH1R PTH2R	6.20e-05	187	51	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX21 AEBP1 GLI3 ITGB4	6.59e-05	190	51	4	78cc6c28b31de041c24175a98f47da256ecc15a2
ToppCell	Primary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Astro-Astrocyte\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SOX21 AEBP1 GLI3 ITGB4	6.59e-05	190	51	4	e67d9400467b438592690b23d681e6c2fb8f09fd
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX21 GLI3 CCDC190 HSD11B1	6.73e-05	191	51	4	fd345837bfc40d85256b9a7e4fd3343bcbfe0ae5
ToppCell	CV-Moderate-0\|CV / Virus stimulation, Condition and Cluster	JAK1 RASGEF1B TNFAIP3 ZBTB1	7.15e-05	194	51	4	9ff69139dae007fcc349daefcb5021defb0e0d2a
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SOX21 ADAMTS6 GLI3 PTH2R	8.04e-05	200	51	4	ed4a41cb6782541d8fc928aaa12cf03bc1c630a2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Radial_glial-RGCs_3\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	SOX21 ADAMTS6 FBL GLI3	8.04e-05	200	51	4	55a1df656545ff078b727d55e4d65d61ddb5c41f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	SOX21 ADAMTS6 GLI3 PTH2R	8.04e-05	200	51	4	792fef1f3e47ce5c131fedfad55075fc254aeead
Disease	primary bacterial infectious disease (implicated_via_orthology)	GLI1 GLI3	8.88e-05	9	47	2	DOID:0050338 (implicated_via_orthology)
Disease	Disproportionate short stature	IFT140 GLI3 PTH1R	2.55e-04	77	47	3	C0878659
Disease	pre-malignant neoplasm (biomarker_via_orthology)	GLI1 GLI3	3.33e-04	17	47	2	DOID:0060071 (biomarker_via_orthology)
Disease	coronary artery disease	IFT140 VPS11 KCNH7 ASIC2 UBE3B RASGEF1B MC4R R3HDM2	5.42e-04	1194	47	8	EFO_0001645
Disease	Polydactyly	IFT140 GLI3 UBE3B	8.68e-04	117	47	3	C0152427
Disease	sporadic amyotrophic lateral sclerosis	WAPL ASIC2 PTH2R	1.45e-03	140	47	3	EFO_0001357

Protein segments in the cluster

Peptide	Gene	Start	Entry
HYAAMHGRARIARLM	ASB7	86	Q9H672
RCLMFLMLYRFGHLK	AGMO	396	Q6ZNB7
DFRHHSYKDMRQLMK	AEBP1	561	Q8IUX7
IGREMAYHLAKMGAH	HSD11B1	46	P28845
MMVGYHGRKDIEHYI	ADAMTS6	261	Q9UKP5
FLHRVGHDLKDMMLY	ASIC2	156	Q16515
NMDLRDFHKYMRSHK	P4HTM	251	Q9NXG6
MTSYHRMLLHRVAAY	R3HDM2	196	Q9Y2K5
RMLLHRVAAYFGMDH	R3HDM2	201	Q9Y2K5
MMRQVSHKHIVYLYG	JAK1	641	P23458
PFKAQYMLVVHMRRH	GLI3	526	P10071
YHMQMLRVKEFIRFH	KCNH7	676	Q9NS40
MERHMVRGQLYKHFD	CCDC190	1	Q86UF4
DHYGIMMYHRNRLIK	MORC3	311	Q14149
LMILDHRLHMAMYFF	OR14K1	46	Q8NGZ2
HRLHMAMYFFLRHLS	OR14K1	51	Q8NGZ2
HGLIEYFHLDMMKLR	PDE7A	181	Q13946
PHKKFFHTRFLMRMR	DCAF10	291	Q5QP82
DARHPHKYRMLIAMV	FBL	216	P22087
YEIHLFKERMFRHQM	L1CAM	1086	P32004
PFKAQYMLVVHMRRH	GLI1	281	P08151
HRMFLLRVKLMHFVN	TUBGCP5	881	Q96RT8
RLFMHPYELMAKVCH	RASGEF1B	71	Q0VAM2
RGHMVGFKEDHYMLR	ITGB4	751	P16144
KEFMSKHVHLMCYRI	GPAT4	206	Q86UL3
MYVGHAVHYVRMEEK	GJA8	91	P48165
TMYQHIKMHRRILGH	BRWD1	171	Q9NSI6
RYMAIAHHRFYAKRM	GPR173	121	Q9NS66
LYVHMFLMARLHIKR	MC4R	211	P32245
STRHLHAMAFYVVKM	MALSU1	131	Q96EH3
MDRAVMLYHKAGHFS	IFT140	1081	Q96RY7
DMKYALHHVFCGMRI	OR11H7	296	Q8NGC8
NYRTLEFLMRHLVHM	ARHGAP30	141	Q7Z6I6
KRPMHILLHDAYMFC	UTP4	591	Q969X6
AKRLRAMHMKEHPDY	SOX21	61	Q9Y651
ERMMGEKLFYLSHLH	SYT16	446	Q17RD7
MFYRKDVMLDHQRRH	PRDM15	861	P57071
RKDHMVRMHLYPADF	ZNF511	161	Q8NB15
AESNMKRYGKILMHH	VPS11	541	Q9H270
IIHHFKTMHRYTLEM	TNFAIP3	36	P21580
HHMRATGGKMAYLLI	DNTTIP1	256	Q9H147
YIHMHLFLSFMLRAV	PTH1R	221	Q03431
RMHLRAHGMVAMVFK	WAPL	691	Q7Z5K2
KHLKHMRRMYGTSLY	TTLL2	161	Q9BWV7
RNYIHMHLFVSFMLR	PTH2R	176	P49190
LRLHNDMHKGMARYV	ZBTB1	621	Q9Y2K1
KISYIHLMAHFRMHT	UBE3B	876	Q7Z3V4
SFMYNYRLMRHKRVH	ZNF548	261	Q8NEK5
MVRKYAFHMILAGHR	TRAPPC8	556	Q9Y2L5
KAKMAHRREILRGMY	TRIM49B	216	A6NDI0
ECGMRFIQKYHMERH	ZNF148	231	Q9UQR1
FLMKGMLFTHTRAHR	ZNF382	221	Q96SR6
LRSLAGMKYHVMANH	ZNF512	206	Q96ME7