Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	catalytic activity, acting on a tRNA	QARS1 LARS2 THG1L	2.03e-03	144	35	3	GO:0140101
GeneOntologyMolecularFunction	small GTPase binding	YIPF2 YIPF1 FARP1 ADCYAP1R1	2.32e-03	321	35	4	GO:0031267
GeneOntologyMolecularFunction	hydrolase activity, hydrolyzing N-glycosyl compounds	MAN2A1 TLR2	2.34e-03	41	35	2	GO:0016799
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	QARS1 LARS2	2.46e-03	42	35	2	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	QARS1 LARS2	2.46e-03	42	35	2	GO:0004812
GeneOntologyMolecularFunction	GTPase binding	YIPF2 YIPF1 FARP1 ADCYAP1R1	3.50e-03	360	35	4	GO:0051020
GeneOntologyCellularComponent	Golgi medial cisterna	YIPF2 MAN2A1 YIPF1	7.44e-06	23	35	3	GO:0005797
GeneOntologyCellularComponent	Golgi trans cisterna	YIPF2 YIPF1	1.48e-04	11	35	2	GO:0000138
GeneOntologyCellularComponent	late endosome membrane	YIPF2 ATP13A3 YIPF1 B2M	2.21e-04	179	35	4	GO:0031902
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	SV2C YIPF2 ATP13A3 YIPF1 B2M SNX13 TLR2 SEC16A	1.18e-03	1307	35	8	GO:0030659
GeneOntologyCellularComponent	vesicle membrane	SV2C YIPF2 ATP13A3 YIPF1 B2M SNX13 TLR2 SEC16A	1.29e-03	1325	35	8	GO:0012506
GeneOntologyCellularComponent	Golgi cisterna	YIPF2 MAN2A1 YIPF1	1.48e-03	135	35	3	GO:0031985
GeneOntologyCellularComponent	transport vesicle	SV2C YIPF2 YIPF1 B2M SEC16A	1.62e-03	519	35	5	GO:0030133
GeneOntologyCellularComponent	late endosome	YIPF2 ATP13A3 YIPF1 B2M	2.63e-03	348	35	4	GO:0005770
GeneOntologyCellularComponent	endosome	YIPF2 ATP13A3 SAMD9L YIPF1 ADCYAP1R1 B2M SNX13	2.82e-03	1167	35	7	GO:0005768
GeneOntologyCellularComponent	Golgi stack	YIPF2 MAN2A1 YIPF1	2.90e-03	171	35	3	GO:0005795
GeneOntologyCellularComponent	endosome membrane	YIPF2 ATP13A3 YIPF1 B2M SNX13	3.09e-03	602	35	5	GO:0010008
Domain	Cu_amine_oxidase	YIPF2 AOC1	1.93e-05	4	34	2	IPR000269
Domain	Yip1	YIPF2 YIPF1	6.72e-05	7	34	2	PF04893
Domain	Yip1	YIPF2 YIPF1	6.72e-05	7	34	2	IPR006977
Domain	aa-tRNA-synth_I_CS	QARS1 LARS2	4.83e-04	18	34	2	IPR001412
Domain	AA_TRNA_LIGASE_I	QARS1 LARS2	5.39e-04	19	34	2	PS00178
Domain	Rossmann-like_a/b/a_fold	QARS1 LARS2	2.77e-03	43	34	2	IPR014729
Domain	-	QARS1 LARS2	2.77e-03	43	34	2	3.40.50.620
Domain	-	ATP13A3 CTDSPL2	6.04e-03	64	34	2	3.40.50.1000
Pathway	REACTOME_MODULATION_BY_MTB_OF_HOST_IMMUNE_SYSTEM	B2M TLR2	6.83e-05	7	26	2	M29822
Pathway	REACTOME_BACTERIAL_INFECTION_PATHWAYS	SV2C B2M TLR2	2.93e-04	71	26	3	M48033
Pubmed	Up-regulated SAMD9L modulated by TLR2 and HIF-1α as a promising biomarker in tuberculosis.	SAMD9L TLR2	2.95e-06	3	35	2	35388602
Pubmed	YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis.	YIPF2 YIPF1	5.90e-06	4	35	2	28286305
Pubmed	Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.	B2M TLR2	5.90e-06	4	35	2	17462991
Pubmed	Apoptotic vesicles crossprime CD8 T cells and protect against tuberculosis.	B2M TLR2	1.47e-05	6	35	2	16413927
Pubmed	Glial TLR2-driven innate immune responses and CD8+ T cell activation against brain tumor.	B2M TLR2	2.06e-05	7	35	2	30720218
Pubmed	NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses.	TLR2 SEC16A	5.38e-05	11	35	2	31114588
Pubmed	A high-density association screen of 155 ion transport genes for involvement with common migraine.	KCNK12 SCN5A	6.45e-05	12	35	2	18676988
Pubmed	Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility.	B2M TLR2	6.45e-05	12	35	2	22933629
Pubmed	Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis.	B2M APOBEC3F	8.89e-05	14	35	2	38967302
Pubmed	Noradrenergic circuit control of non-REM sleep substates.	B2M APOBEC3F	8.89e-05	14	35	2	34648731
Pubmed	Phosphoproteomic of the acetylcholine pathway enables discovery of the PKC-β-PIX-Rac1-PAK cascade as a stimulatory signal for aversive learning.	B2M APOBEC3F	8.89e-05	14	35	2	35665767
Pubmed	Early loss of cerebellar Purkinje cells in human and a transgenic mouse model of Alzheimer's disease.	B2M APOBEC3F	8.89e-05	14	35	2	33688799
Pubmed	Axotomy-induced target disconnection promotes an additional death mechanism involved in motoneuron degeneration in amyotrophic lateral sclerosis transgenic mice.	B2M APOBEC3F	8.89e-05	14	35	2	24424947
Pubmed	The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.	B2M APOBEC3F	8.89e-05	14	35	2	36787309
Pubmed	Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets.	B2M APOBEC3F	1.02e-04	15	35	2	35719268
Pubmed	AdipoRon accelerates bone repair of calvarial defect in diet-induced obesity mice.	B2M APOBEC3F	1.02e-04	15	35	2	36873496
Pubmed	Behavioral and cortical arousal from sleep, muscimol-induced coma, and anesthesia by direct optogenetic stimulation of cortical neurons.	B2M APOBEC3F	1.02e-04	15	35	2	38812551
Pubmed	Activation of neuronal Ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and axonal plasticity in mice.	B2M APOBEC3F	1.02e-04	15	35	2	32964455
Pubmed	δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions.	B2M APOBEC3F	1.02e-04	15	35	2	37707499
Pubmed	Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.	B2M APOBEC3F	1.02e-04	15	35	2	37883185
Pubmed	ERG K+ channels mediate a major component of action potential repolarization in lymphatic muscle.	B2M APOBEC3F	1.02e-04	15	35	2	37689781
Pubmed	Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior.	B2M APOBEC3F	1.17e-04	16	35	2	36049479
Pubmed	Asprosin-neutralizing antibodies as a treatment for metabolic syndrome.	B2M APOBEC3F	1.17e-04	16	35	2	33904407
Pubmed	Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.	B2M APOBEC3F	1.33e-04	17	35	2	30995469
Pubmed	The bone microenvironment invigorates metastatic seeds for further dissemination.	B2M APOBEC3F	1.33e-04	17	35	2	33878291
Pubmed	Movement-related increases in subthalamic activity optimize locomotion.	B2M APOBEC3F	1.33e-04	17	35	2	39068661
Pubmed	A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.	B2M APOBEC3F	1.33e-04	17	35	2	37034992
Pubmed	Vagal sensory neurons mediate the Bezold-Jarisch reflex and induce syncope.	B2M APOBEC3F	1.49e-04	18	35	2	37914931
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	AOC1 MAN2A1 LARS2 KCNQ4	1.67e-04	276	35	4	28319085
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	B2M APOBEC3F	2.46e-04	23	35	2	34473953
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNK12 KCNQ4 SCN5A	3.72e-04	139	35	3	16985003
Pubmed	Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions.	NOX3 KCNQ4	3.93e-04	29	35	2	24952082
Pubmed	EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.	MMP12 TLR2	9.06e-04	44	35	2	35493520
GeneFamily	Yip1 domain containing	YIPF2 YIPF1	4.83e-05	7	28	2	105
GeneFamily	Aminoacyl tRNA synthetases, Class I	QARS1 LARS2	3.89e-04	19	28	2	131
ToppCell	facs-Brain_Myeloid-Cerebellum_-18m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L LARS2 B2M TLR2	7.59e-06	161	35	4	b14a83ad07a7acb07c766aa862b527698976b6fc
ToppCell	facs-Brain_Myeloid-Cerebellum_\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L LARS2 B2M TLR2	7.59e-06	161	35	4	5c762609531a7c5505aa5637abf8e0311568d7fd
ToppCell	facs-Brain_Myeloid-Cerebellum_-18m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L LARS2 B2M TLR2	7.59e-06	161	35	4	c5d9d47dcedfbb1ac77f4afaf860ae4d9f26fd3f
ToppCell	facs-Brain_Myeloid-Cerebellum_-18m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L LARS2 B2M TLR2	7.59e-06	161	35	4	26c0d876339bfd34d9a43af5b9fb08f50526f2c9
ToppCell	facs-Brain_Myeloid-Cerebellum_-18m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD9L LARS2 B2M TLR2	8.56e-06	166	35	4	4ab1959c526c2fd83077fc03e4de207f34841a19
Computational	Genes in the cancer module 35.	QARS1 LARS2	3.50e-04	16	19	2	MODULE_35
Disease	tea consumption measurement	NOX3 NAA25 SNX13	4.82e-04	129	35	3	EFO_0010091
Disease	solar lentigines measurement	MMP12 NT5C1B	6.63e-04	32	35	2	EFO_0007850
Disease	carbohydrate intake measurement	NAA25 PJA1	7.49e-04	34	35	2	EFO_0010811
Disease	complement factor H-related protein 5 measurement	TLR2 THG1L	1.14e-03	42	35	2	EFO_0008098
Disease	TPE interval measurement	AOC1 SCN5A	1.75e-03	52	35	2	EFO_0004644

Protein segments in the cluster

Peptide	Gene	Start	Entry
DDYEAAYWASMRSFY	NT5C1B	276	Q96P26
FSKDWSFYLLYYTEF	B2M	76	P61769
ATYEEDWEVFDPYYF	CTDSPL2	246	Q05D32
FSVILWSTDEYYYYA	ATP13A3	221	Q9H7F0
YYEVWDTEPSFNVSY	A4GNT	271	Q9UNA3
STVYNYDYIWDFIFY	AOC1	456	P19801
SSFEDVDIFYSFWYN	DNAJC2	206	Q99543
RTYFFVDNQYWRYDE	MMP12	391	P39900
YADRDDHYWSGYFTS	MAN2A1	496	Q16706
DMSRAYLTATWYYYD	KCNQ4	356	P56696
WDYVDSLYFCFVTFS	KCNK12	241	Q9HB15
DFWYATYTLYSVSEK	TUBGCP5	506	Q96RT8
VETFFPERRYFYWYT	ADCYAP1R1	256	P41586
IFTARLYYFWDTDYQ	APOBEC3F	301	Q8IUX4
EEYQDSFERYSYLWT	DNAH17	981	Q9UFH2
SDYYTDYVATRWYRS	CDKL1	156	Q00532
VYYFRAESEYTFERW	FARP1	1006	Q9Y4F1
KVTYASDYFDQLYAW	QARS1	331	P47897
VQYWYYTLSDDESFL	SNX13	116	Q9Y5W8
ITFDDDYSAYWIYFV	SV2C	571	Q496J9
DTFVDSAWYYFRYTD	LARS2	521	Q15031
WNFYFSSENYSSDFV	SAMD9L	696	Q8IVG5
WTKYVEYTFTAIYTF	SCN5A	156	Q14524
FYWYEEEESFHYTRV	NOX3	31	Q9HBY0
SSWEYYASVYTERFM	FAP	651	Q12884
FWTFEYYQTFFDVDT	YIPF1	76	Q9Y548
ASNSDYTWEYEYYEI	MRAP2	16	Q96G30
TYDRRYWCDAEYDAY	SEC16A	1286	O15027
SQFASSYVFYWRDYF	THG1L	131	Q9NWX6
VTDYRDWTDTNYYSE	TSPAN6	156	O43657
YDYSASEYRWHINFT	SCD	306	O00767
GFWTFSYYQSFFDVD	YIPF2	76	Q9BWQ6
YDAFVSYSERDAYWV	TLR2	641	O60603
ADPDFWTHSDDYYKY	PJA1	346	Q8NG27
YDYYSKAEAHFERSW	LEG1	226	Q6P5S2
DDWQFYLTYFDSVFR	NAA25	261	Q14CX7