Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium channel activity	TRPV5 TRPV6 TRPA1	2.77e-04	129	20	3	GO:0005262
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	TRPV5 TRPV6 TRPA1	4.40e-04	151	20	3	GO:0015085
GeneOntologyMolecularFunction	telomeric DNA binding	UPF2 SMG5	7.27e-04	40	20	2	GO:0042162
GeneOntologyMolecularFunction	calmodulin binding	ASPM TRPV5 TRPV6	1.49e-03	230	20	3	GO:0005516
GeneOntologyMolecularFunction	phosphatase binding	CLEC12A SMG5 SFI1	2.21e-03	264	20	3	GO:0019902
GeneOntologyMolecularFunction	monoatomic cation channel activity	TRPV5 TRPV6 TRPA1	4.61e-03	343	20	3	GO:0005261
GeneOntologyBiologicalProcess	protein homotetramerization	TRPV5 TRPV6 TRPA1	4.64e-05	77	19	3	GO:0051289
GeneOntologyBiologicalProcess	dendrite arborization	AFDN CNTNAP2	8.38e-05	15	19	2	GO:0140059
GeneOntologyBiologicalProcess	regulation of neuronal action potential	TRPA1 CNTNAP2	8.38e-05	15	19	2	GO:0098908
GeneOntologyBiologicalProcess	protein tetramerization	TRPV5 TRPV6 TRPA1	1.46e-04	113	19	3	GO:0051262
GeneOntologyBiologicalProcess	regulation of transmission of nerve impulse	TRPA1 CNTNAP2	3.00e-04	28	19	2	GO:0051969
Domain	TRPV5/TRPV6	TRPV5 TRPV6	1.09e-06	2	20	2	IPR008344
Domain	TRP_channel	TRPV5 TRPV6	5.96e-05	11	20	2	IPR004729
Domain	Ion_trans_dom	TRPV5 TRPV6 TRPA1	2.34e-04	114	20	3	IPR005821
Domain	Ion_trans	TRPV5 TRPV6 TRPA1	2.34e-04	114	20	3	PF00520
Domain	Ank_2	TRPV5 TRPV6 TRPA1	1.48e-03	215	20	3	PF12796
Domain	Ank	TRPV5 TRPV6 TRPA1	1.76e-03	228	20	3	PF00023
Domain	-	TRPV5 TRPV6 TRPA1	2.23e-03	248	20	3	1.25.40.20
Domain	ANK	TRPV5 TRPV6 TRPA1	2.31e-03	251	20	3	SM00248
Domain	ANK_REPEAT	TRPV5 TRPV6 TRPA1	2.36e-03	253	20	3	PS50088
Domain	Ankyrin_rpt-contain_dom	TRPV5 TRPV6 TRPA1	2.39e-03	254	20	3	IPR020683
Domain	ANK_REP_REGION	TRPV5 TRPV6 TRPA1	2.39e-03	254	20	3	PS50297
Domain	Ankyrin_rpt	TRPV5 TRPV6 TRPA1	2.61e-03	262	20	3	IPR002110
Domain	-	MYCBP2 CNTNAP2	2.74e-03	73	20	2	2.60.120.260
Domain	Galactose-bd-like	MYCBP2 CNTNAP2	4.49e-03	94	20	2	IPR008979
Domain	-	MYCBP2 MKRN1 USP22	1.16e-02	449	20	3	3.30.40.10
Domain	Znf_RING/FYVE/PHD	MYCBP2 MKRN1 USP22	1.23e-02	459	20	3	IPR013083
Pathway	REACTOME_TRP_CHANNELS	TRPV5 TRPV6 TRPA1	3.86e-06	28	16	3	M27241
Pathway	REACTOME_TRP_CHANNELS	TRPV5 TRPV6 TRPA1	3.86e-06	28	16	3	MM14943
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPV5 TRPV6 TRPA1	1.76e-04	99	16	3	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	TRPV5 TRPV6 TRPA1	2.16e-04	106	16	3	M27200
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPV5 TRPV6 TRPA1	9.51e-04	176	16	3	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	TRPV5 TRPV6 TRPA1	1.06e-03	183	16	3	M997
Pubmed	Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3.	TRPV5 TRPV6	3.14e-07	2	20	2	12077127
Pubmed	Interaction of the epithelial Ca2+ channels TRPV5 and TRPV6 with the intestine- and kidney-enriched PDZ protein NHERF4.	TRPV5 TRPV6	3.14e-07	2	20	2	16565876
Pubmed	Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium.	TRPV5 TRPV6	3.14e-07	2	20	2	20405023
Pubmed	Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.	TRPV5 TRPV6	3.14e-07	2	20	2	20178461
Pubmed	The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.	TRPV5 TRPV6	3.14e-07	2	20	2	22354706
Pubmed	Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane.	TRPV5 TRPV6	3.14e-07	2	20	2	16564089
Pubmed	Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2.	TRPV5 TRPV6	3.14e-07	2	20	2	11719848
Pubmed	A single amino acid mutation results in a rapid inactivation of epithelial calcium channels.	TRPV5 TRPV6	3.14e-07	2	20	2	11846401
Pubmed	Concerted action of associated proteins in the regulation of TRPV5 and TRPV6.	TRPV5 TRPV6	3.14e-07	2	20	2	17233615
Pubmed	First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.	TRPV5 TRPV6	3.14e-07	2	20	2	25164318
Pubmed	Endogenous expression of TRPV5 and TRPV6 calcium channels in human leukemia K562 cells.	TRPV5 TRPV6	3.14e-07	2	20	2	19295174
Pubmed	Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.	TRPV5 TRPV6	3.14e-07	2	20	2	23968883
Pubmed	Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta.	TRPV5 TRPV6	3.14e-07	2	20	2	12390878
Pubmed	[The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].	TRPV5 TRPV6	3.14e-07	2	20	2	24592736
Pubmed	Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6.	TRPV5 TRPV6	3.14e-07	2	20	2	12574114
Pubmed	Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6.	TRPV5 TRPV6	3.14e-07	2	20	2	16705151
Pubmed	Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.	TRPV5 TRPV6	3.14e-07	2	20	2	24761864
Pubmed	Structural conservation of the genes encoding CaT1, CaT2, and related cation channels.	TRPV5 TRPV6	3.14e-07	2	20	2	11549322
Pubmed	[TRPV5 and TRPV6 calcium channels in human T cells].	TRPV5 TRPV6	3.14e-07	2	20	2	19140341
Pubmed	TRPV5 and TRPV6 are expressed in placenta and bone tissues during pregnancy in mice.	TRPV5 TRPV6	3.14e-07	2	20	2	30916584
Pubmed	Regulation of the mouse epithelial Ca2(+) channel TRPV6 by the Ca(2+)-sensor calmodulin.	TRPV5 TRPV6	3.14e-07	2	20	2	15123711
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPV5 TRPV6 TRPA1	3.27e-07	24	20	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPV5 TRPV6 TRPA1	3.71e-07	25	20	3	16382100
Pubmed	An introduction to TRP channels.	TRPV5 TRPV6 TRPA1	4.71e-07	27	20	3	16460286
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPV5 TRPV6 TRPA1	8.77e-07	33	20	3	19834762
Pubmed	Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.	TRPV5 TRPV6	9.42e-07	3	20	2	17200157
Pubmed	Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear.	TRPV5 TRPV6	9.42e-07	3	20	2	19922080
Pubmed	Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport.	TRPV5 TRPV6	9.42e-07	3	20	2	16763551
Pubmed	Identification of BSPRY as a novel auxiliary protein inhibiting TRPV5 activity.	TRPV5 TRPV6	9.42e-07	3	20	2	16380433
Pubmed	A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.	TRPV5 TRPV6	9.42e-07	3	20	2	27291418
Pubmed	Direct interaction with Rab11a targets the epithelial Ca2+ channels TRPV5 and TRPV6 to the plasma membrane.	TRPV5 TRPV6	9.42e-07	3	20	2	16354700
Pubmed	Functional expression of the epithelial Ca(2+) channels (TRPV5 and TRPV6) requires association of the S100A10-annexin 2 complex.	TRPV5 TRPV6	1.88e-06	4	20	2	12660155
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPV5 TRPV6 TRPA1	2.12e-06	44	20	3	19322198
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPV5 TRPV6	3.14e-06	5	20	2	12765698
Pubmed	Calcium transport genes are differently regulated in maternal and fetal placenta in the knockout mice of calbindin-D(9k) and -D(28k).	TRPV5 TRPV6	3.14e-06	5	20	2	22407925
Pubmed	Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.	UPF2 SMG5	4.71e-06	6	20	2	25770585
Pubmed	Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.	UPF2 SMG5	6.59e-06	7	20	2	17916692
Pubmed	Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.	UPF2 SMG5	6.59e-06	7	20	2	14636577
Pubmed	Cyclin M2 (CNNM2) knockout mice show mild hypomagnesaemia and developmental defects.	TRPV5 TRPV6	8.78e-06	8	20	2	33859252
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	UPF2 SMG5	1.13e-05	9	20	2	16488880
Pubmed	Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay.	UPF2 SMG5	2.07e-05	12	20	2	21145460
Pubmed	SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.	UPF2 SMG5	2.44e-05	13	20	2	20930030
Pubmed	Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos.	TRPV5 TRPV6	2.44e-05	13	20	2	22266179
Pubmed	Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SMG5 USP22 ZNF507	2.85e-05	104	20	3	10470851
Pubmed	Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins.	ASPM SFI1	3.75e-05	16	20	2	29764992
Pubmed	Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.	SFI1 CNTNAP2	4.78e-05	18	20	2	24939585
Pubmed	Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.	MGP TRPV6	6.55e-05	21	20	2	23895994
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	UPF2 SMG5	1.26e-04	29	20	2	20371770
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	UPF2 MYCBP2 ZBTB38 MKRN1	1.66e-04	497	20	4	23414517
Pubmed	The sperm-associated antigen 6 interactome and its role in spermatogenesis.	MGP MYCBP2 USP22	1.96e-04	199	20	3	31146259
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	UPF2 MYCBP2 AFDN	2.05e-04	202	20	3	24639526
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SMG5 SFI1 ZNF507 CNTNAP2	2.11e-04	529	20	4	14621295
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	TRPV5 TRPV6	2.18e-04	38	20	2	30786075
Pubmed	14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation.	MYCBP2 AFDN	2.67e-04	42	20	2	23444366
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRPV5 TRPV6 MKRN1	6.98e-05	185	20	3	chr7q34
Cytoband	7q35	TRPV5 CNTNAP2	2.64e-04	55	20	2	7q35
Cytoband	7q34	TRPV6 MKRN1	2.39e-03	167	20	2	7q34
GeneFamily	Transient receptor potential cation channels	TRPV5 TRPV6 TRPA1	1.49e-06	28	15	3	249
GeneFamily	Ankyrin repeat domain containing	TRPV5 TRPV6 TRPA1	9.57e-04	242	15	3	403
Coexpression	GSE3982_MAST_CELL_VS_BCELL_DN	TRPV6 SFI1 TRPA1 CNTNAP2	1.36e-05	197	20	4	M5437
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM MYCBP2 ALPK2	4.99e-05	162	20	3	93bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ALPK2 ARID3B ZNF507	5.09e-05	163	20	3	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c12-MKI67-TYROBP\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MGP SMG5 ZNF507	5.18e-05	164	20	3	4ef776d1bab4103d42d3a4f22cdfb49e8d2bc5a0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZBTB38 TRPA1 ZNF507	6.39e-05	176	20	3	5914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM CLEC12A KMT5A	6.61e-05	178	20	3	15a99080e9f669572ab6d82934f324e6714846c1
ToppCell	facs-Marrow-Granulocytes-18m-Myeloid-granulocytopoietic_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM CLEC12A KMT5A	6.61e-05	178	20	3	200308e109abb7e6f8816a6f8cce6d56862d4098
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGP ASPM ZBTB38	7.53e-05	186	20	3	4ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGP ASPM ZBTB38	7.53e-05	186	20	3	15ab6666748a641226e42e6ca6eeaf186a501c95
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MGP MYCBP2 ZBTB38	8.92e-05	197	20	3	cfd4cc5fb8d7a60dd5c0d2a1a7bad7ba38c19d40
ToppCell	LPS_only-Endothelial-Endothelial-FOXM1\|LPS_only / Treatment groups by lineage, cell group, cell type	ASPM KMT5A ZNF507	8.92e-05	197	20	3	038fd92750257d43d5e980fd06d77742b543f11a
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	UPF2 AFDN ALPK2	9.19e-05	199	20	3	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASPM TRPV5 MKRN1	9.19e-05	199	20	3	565404c155dfac57c020a8f2d09cbf756da20ffd
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Degenerative_Connecting_Tubule_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MGP TRPV5 TRPV6	9.19e-05	199	20	3	5059a1d4df7d9989c922007a8dcba98b1f5687d5
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASPM TRPV5 MKRN1	9.19e-05	199	20	3	284ee9632413f6404fc0b0c7c393ad813db834f2
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MGP TRPV5 TRPV6	9.19e-05	199	20	3	a4ebb0598e9a0c9f6e39a0db6d0623654c2a7d88
ToppCell	LPS_anti-TNF-Hematopoietic_Erythro-Megakary\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ASPM TRPV5 MKRN1	9.19e-05	199	20	3	6c174dbcc25b980f10a3d1dfe39e613acac73bb6
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	MYCBP2 AFDN CNTNAP2	9.33e-05	200	20	3	bad32a95b759fad509401b07bc96a56687c2a592
Drug	Chicago sky blue 6B [2610-05-1]; Down 200; 4uM; PC3; HT_HG-U133A	AFDN TRPV6 SMG5 CNTNAP2	2.27e-05	195	20	4	6626_DN
Drug	Quipazine dimaleate salt [4774-24-7]; Up 200; 9uM; MCF7; HT_HG-U133A	AFDN TRPV6 SFI1 CNTNAP2	2.32e-05	196	20	4	7240_UP
Drug	Fluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; PC3; HT_HG-U133A	MGP AFDN TRPA1 CNTNAP2	2.36e-05	197	20	4	5741_UP
Drug	Khellin [82-02-0]; Down 200; 15.4uM; PC3; HT_HG-U133A	MGP AFDN SMG5 CNTNAP2	2.41e-05	198	20	4	6641_DN
Drug	Cefaclor [70356-03-5]; Down 200; 10.4uM; PC3; HT_HG-U133A	MGP AFDN SMG5 CNTNAP2	2.41e-05	198	20	4	6622_DN
Drug	Lymecycline [992-21-2]; Up 200; 6.6uM; HL60; HT_HG-U133A	AFDN SMG5 SFI1 CNTNAP2	2.46e-05	199	20	4	2953_UP
Drug	3,5-bis(trifluoromethyl)pyrazole	TRPV5 TRPV6	3.28e-05	10	20	2	CID000518991
Drug	capsazepine	TRPV5 TRPV6 TRPA1	5.28e-05	84	20	3	CID002733484
Drug	menthol	TRPV5 ALPK2 TRPA1	5.86e-05	87	20	3	CID000001254
Drug	TRK-820	MGP TRPA1	6.63e-05	14	20	2	CID006445230
Drug	AC1LWLPQ	TRPV5 TRPV6	8.73e-05	16	20	2	CID001778727
Drug	sodium	MGP UPF2 TRPV5 TRPV6 ALPK2 CNTNAP2	1.18e-04	944	20	6	CID000000923
Drug	Gadolinium	TRPV6 TRPA1	1.52e-04	21	20	2	ctd:D005682
Drug	pH-6	MGP TRPV6	1.52e-04	21	20	2	CID000478566
Drug	florfenicol	TRPV5 TRPV6	1.52e-04	21	20	2	CID000114811
Drug	potassium	AFDN TRPV5 TRPV6 ALPK2 TRPA1 CNTNAP2	1.68e-04	1008	20	6	CID000000813
Drug	AC1L8UHC	TRPV5 TRPV6	1.83e-04	23	20	2	CID000432954
Drug	lanthanum	TRPV5 TRPV6 TRPA1	2.21e-04	136	20	3	CID000023926
Drug	alfacalcidol	TRPV5 TRPV6	2.35e-04	26	20	2	ctd:C008088
Drug	1kwq	TRPV5 TRPV6	2.35e-04	26	20	2	CID003092847
Drug	chlorpropham	MGP AFDN	2.35e-04	26	20	2	CID000002728
Drug	Dantrolene-13C3	MGP TRPV6 TRPA1	2.66e-04	145	20	3	CID000002951
Drug	Bay K 8644	TRPV5 TRPV6 TRPA1	2.94e-04	150	20	3	CID000002303
Drug	SNC80	MGP TRPA1	3.36e-04	31	20	2	CID000123924
Drug	CNS 1145	TRPV6 TRPA1	3.81e-04	33	20	2	CID000190902
Drug	IHC-64	TRPV6 TRPA1	3.81e-04	33	20	2	CID000162753
Drug	1,25-dihydroxyvitamin D	TRPV6 KMT5A	4.29e-04	35	20	2	ctd:C097949
Drug	norflurazon	TRPV5 TRPV6	4.29e-04	35	20	2	CID000033775
Drug	2-chlorobenzoate	TRPV5 TRPV6	4.54e-04	36	20	2	CID000008374
Drug	Withaferin A [5119-48-2]; Down 200; 1uM; PC3; HT_HG-U133A	SMG5 SFI1 CNTNAP2	4.94e-04	179	20	3	4554_DN
Drug	S-(p-nitrobenzyl)-6-thioinosine	MGP UPF2	5.33e-04	39	20	2	CID000005129
Drug	C09179	TRPV5 TRPA1	5.33e-04	39	20	2	CID000442082
Drug	Methylprednisolone, 6-alpha [83-43-2]; Up 200; 10.6uM; MCF7; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.15e-04	193	20	3	3183_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	TRPV6 SFI1 CNTNAP2	6.15e-04	193	20	3	5584_DN
Drug	hydroxyvaline	TRPV5 TRPV6	6.18e-04	42	20	2	CID000095562
Drug	Dosulepin hydrochloride [897-15-4]; Down 200; 12uM; MCF7; HT_HG-U133A	TRPV6 SMG5 SFI1	6.24e-04	194	20	3	2864_DN
Drug	Estrone [53-16-7]; Up 200; 14.8uM; HL60; HT_HG-U133A	AFDN TRPV5 SFI1	6.24e-04	194	20	3	3071_UP
Drug	Sulmazole [73384-60-8]; Down 200; 14uM; HL60; HT_HG-U133A	TRPV6 SMG5 ZBTB38	6.33e-04	195	20	3	2153_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A	TRPV6 SFI1 CNTNAP2	6.33e-04	195	20	3	4399_DN
Drug	Bethanechol chloride [590-63-6]; Up 200; 20.4uM; HL60; HT_HG-U133A	AFDN SMG5 SFI1	6.33e-04	195	20	3	2975_UP
Drug	CP-690334-01 [459212-38-5]; Up 200; 1uM; PC3; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.43e-04	196	20	3	3826_UP
Drug	Tridihexethyl chloride; Up 200; 11.4uM; HL60; HT_HG-U133A	AFDN TRPV6 SMG5	6.43e-04	196	20	3	2964_UP
Drug	Tocainide hydrochloride; Down 200; 17.4uM; PC3; HT_HG-U133A	MGP AFDN CNTNAP2	6.43e-04	196	20	3	4256_DN
Drug	Progesterone [57-83-0]; Up 200; 12.8uM; PC3; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.43e-04	196	20	3	6646_UP
Drug	Diphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; MCF7; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.43e-04	196	20	3	6061_UP
Drug	Bisoprolol fumarate; Down 200; 9uM; PC3; HT_HG-U133A	TRPV6 SFI1 CNTNAP2	6.43e-04	196	20	3	6748_DN
Drug	Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; MCF7; HT_HG-U133A	SMG5 SFI1 CNTNAP2	6.52e-04	197	20	3	4986_DN
Drug	Betahistine mesylate [54856-23-4]; Down 200; 17.2uM; PC3; HT_HG-U133A	MGP AFDN TRPV6	6.52e-04	197	20	3	6611_DN
Drug	Desipramine hydrochloride [58-28-6]; Down 200; 13.2uM; MCF7; HT_HG-U133A	TRPV6 SMG5 SFI1	6.52e-04	197	20	3	3212_DN
Drug	Lansoprazole [103577-45-3]; Up 200; 10.8uM; HL60; HT_HG-U133A	AFDN TRPV6 SFI1	6.52e-04	197	20	3	2967_UP
Drug	Meclofenoxate hydrochloride [3685-84-5]; Up 200; 13.6uM; MCF7; HT_HG-U133A	AFDN SMG5 CNTNAP2	6.52e-04	197	20	3	4729_UP
Drug	Atropine-N-oxide hydrochloride [4574-60-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	AFDN SMG5 SFI1	6.62e-04	198	20	3	4476_UP
Drug	Procarbazine hydrochloride [366-70-1]; Up 200; 15.6uM; HL60; HT_HG-U133A	AFDN ZBTB38 SFI1	6.62e-04	198	20	3	2971_UP
Drug	6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.62e-04	198	20	3	6073_UP
Drug	Procainamide hydrochloride [614-39-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.62e-04	198	20	3	5663_UP
Drug	Chlorthalidone [77-36-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A	AFDN SFI1 CNTNAP2	6.72e-04	199	20	3	3198_UP
Drug	Benzydamine hydrochloride [132-69-4]; Up 200; 11.6uM; HL60; HG-U133A	MYCBP2 SMG5 SFI1	6.72e-04	199	20	3	1552_UP
Drug	Theobromine [83-67-0]; Up 200; 22.2uM; HL60; HT_HG-U133A	AFDN ZBTB38 CNTNAP2	6.72e-04	199	20	3	2995_UP
Drug	gadolinium	TRPV5 TRPV6 TRPA1	6.72e-04	199	20	3	CID000023982
Drug	Clozapine [5786-21-0]; Down 200; 12.2uM; PC3; HT_HG-U133A	MGP SMG5 CNTNAP2	6.72e-04	199	20	3	4670_DN
Drug	Oxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; PC3; HT_HG-U133A	AFDN TRPV6 CNTNAP2	6.72e-04	199	20	3	6624_DN
Drug	Merbromin [129-16-8]; Down 200; 5uM; HL60; HT_HG-U133A	MGP AFDN TRPV6	6.72e-04	199	20	3	2577_DN
Drug	methoxyl	ARID3B MTNR1A	6.78e-04	44	20	2	CID000123146
Disease	visual epilepsy (is_implicated_in)	ASPM CNTNAP2	2.39e-05	11	20	2	DOID:11832 (is_implicated_in)
Disease	family history of Alzheimer’s disease	ALPK2 CNTNAP2	1.05e-03	71	20	2	EFO_0009268
Disease	age-related hearing impairment	SFI1 MKRN1 CNTNAP2	1.30e-03	324	20	3	EFO_0005782
Disease	Autism Spectrum Disorders	CNTNAP2 MTNR1A	1.51e-03	85	20	2	C1510586
Disease	cancer	TRPV5 TRPV6 ZBTB38	2.37e-03	400	20	3	MONDO_0004992
Disease	anxiety measurement	TRPV5 TRPV6	2.42e-03	108	20	2	EFO_0009863
Disease	Alzheimer disease, family history of Alzheimer’s disease	ALPK2 CNTNAP2	2.92e-03	119	20	2	EFO_0009268, MONDO_0004975
Disease	Sclerocystic Ovaries	ASPM TRPV6	4.24e-03	144	20	2	C1136382
Disease	Polycystic Ovary Syndrome	ASPM TRPV6	4.24e-03	144	20	2	C0032460
Disease	nasopharyngeal neoplasm	ZNF507 CNTNAP2	4.65e-03	151	20	2	EFO_0004252
Disease	non-alcoholic fatty liver disease	ALPK2 CNTNAP2	6.68e-03	182	20	2	EFO_0003095
Disease	neutrophil percentage of leukocytes	KMT5A ZBTB38 SFI1	7.71e-03	610	20	3	EFO_0007990
Disease	osteoarthritis	KMT5A ALPK2	9.79e-03	222	20	2	MONDO_0005178

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVLYMACRYVLSNQY	AFDN	636	P55196
LRTQYMKYLYAYECE	ARID3B	291	Q8IVW6
ECYVQNTARYYAKIY	ALPK2	1981	Q86TB3
QSTYRMYRQYCFYQK	ASPM	2561	Q8IZT6
CYMYYFQYLSKTYCV	KMT5A	311	Q9NQR1
YCEQYVSYFCKMSRL	CNTNAP2	681	Q9UHC6
YRLCERYAMVYGYNA	MGP	76	P08493
DARYVTMVENAYYYC	UPF2	741	Q9HAU5
YSVVCKYFQRGYCIY	MKRN1	86	Q9UHC7
DCHYRYYLYNLMFQT	SFI1	146	A8K8P3
YYNVEAMYCYLRCIQ	SMG5	226	Q9UPR3
MNRYAYYVCYKCRKA	MYCBP2	4536	O75592
YCGYINRLYVQYYHC	CLEC12A	226	Q5QGZ9
MYGGIYCFLCQDYIY	USP22	106	Q9UPT9
CRDYYIEYNFKYLQC	TRPA1	651	O75762
YLLYIICFTMCCIYR	TRPV6	376	Q9H1D0
AYEQYGMYRCLFCSY	ZNF507	241	Q8TCN5
YQCIFCLETFMTYYI	ZBTB38	516	Q8NAP3
YLLYMICFTTCCVYR	TRPV5	336	Q9NQA5
YYMAYFNSCLNAIIY	MTNR1A	281	P48039