Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	1.86e-06	60	68	5	GO:0005544
GeneOntologyMolecularFunction	iron-responsive element binding	ACO1 IREB2	3.42e-05	3	68	2	GO:0030350
GeneOntologyMolecularFunction	endothelin receptor activity	EDNRA EDNRB	3.42e-05	3	68	2	GO:0004962
GeneOntologyMolecularFunction	aconitate hydratase activity	ACO1 IREB2	3.42e-05	3	68	2	GO:0003994
GeneOntologyMolecularFunction	hexose-phosphate:phosphate antiporter activity	SLC37A1 SLC37A2	6.83e-05	4	68	2	GO:0015526
GeneOntologyMolecularFunction	hexose phosphate transmembrane transporter activity	SLC37A1 SLC37A2	6.83e-05	4	68	2	GO:0015119
GeneOntologyMolecularFunction	glucose-6-phosphate transmembrane transporter activity	SLC37A1 SLC37A2	6.83e-05	4	68	2	GO:0015152
GeneOntologyMolecularFunction	glucose 6-phosphate:phosphate antiporter activity	SLC37A1 SLC37A2	6.83e-05	4	68	2	GO:0061513
GeneOntologyMolecularFunction	iron-sulfur cluster binding	ACO1 XDH IREB2 NDUFS1	1.45e-04	78	68	4	GO:0051536
GeneOntologyMolecularFunction	metal cluster binding	ACO1 XDH IREB2 NDUFS1	1.85e-04	83	68	4	GO:0051540
GeneOntologyMolecularFunction	organophosphate:phosphate antiporter activity	SLC37A1 SLC37A2	2.37e-04	7	68	2	GO:0015315
GeneOntologyMolecularFunction	nitrite reductase (NO-forming) activity	XDH CBS	2.37e-04	7	68	2	GO:0050421
GeneOntologyMolecularFunction	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor	XDH CBS	2.37e-04	7	68	2	GO:0016662
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	2.37e-04	7	68	2	GO:0019770
GeneOntologyMolecularFunction	4 iron, 4 sulfur cluster binding	ACO1 IREB2 NDUFS1	5.50e-04	47	68	3	GO:0051539
GeneOntologyMolecularFunction	nitrite reductase activity	XDH CBS	6.16e-04	11	68	2	GO:0098809
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2B	6.16e-04	11	68	2	GO:0019864
GeneOntologyMolecularFunction	lyase activity	TKFC ACO1 IREB2 CBS HDC	7.79e-04	212	68	5	GO:0016829
GeneOntologyMolecularFunction	pyridoxal phosphate binding	OAT CBS HDC	9.20e-04	56	68	3	GO:0030170
GeneOntologyMolecularFunction	vitamin B6 binding	OAT CBS HDC	9.69e-04	57	68	3	GO:0070279
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2B	1.01e-03	14	68	2	GO:0019763
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	PROKR1 SORCS3 EDNRA EDNRB	1.10e-03	133	68	4	GO:0008528
GeneOntologyMolecularFunction	hydro-lyase activity	ACO1 IREB2 CBS	1.30e-03	63	68	3	GO:0016836
GeneOntologyMolecularFunction	peptide receptor activity	PROKR1 SORCS3 EDNRA EDNRB	1.33e-03	140	68	4	GO:0001653
GeneOntologyMolecularFunction	oxidoreductase activity, acting on other nitrogenous compounds as donors	XDH CBS	1.50e-03	17	68	2	GO:0016661
GeneOntologyMolecularFunction	phospholipid binding	CPNE8 CPNE9 ADGRB1 CPNE1 PLA2G4D CPNE5 GSN	2.58e-03	548	68	7	GO:0005543
GeneOntologyMolecularFunction	carbon-oxygen lyase activity	ACO1 IREB2 CBS	2.76e-03	82	68	3	GO:0016835
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC37A1 SLC37A2	3.00e-03	24	68	2	GO:0005315
GeneOntologyMolecularFunction	kinase activity	JAK1 SEPHS2 TKFC DGKK DOLK DAPK1 STKLD1 EDNRA	4.31e-03	764	68	8	GO:0016301
GeneOntologyMolecularFunction	2 iron, 2 sulfur cluster binding	XDH NDUFS1	4.37e-03	29	68	2	GO:0051537
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	JAK1 SEPHS2 NMNAT2 TKFC DGKK DOLK DAPK1 STKLD1 EDNRA	4.38e-03	938	68	9	GO:0016772
GeneOntologyMolecularFunction	solute:inorganic anion antiporter activity	SLC37A1 SLC37A2	5.31e-03	32	68	2	GO:0005452
GeneOntologyMolecularFunction	ubiquitin protein ligase binding	JAK1 MAGEA6 TSG101 HERC2 CBS	5.81e-03	337	68	5	GO:0031625
GeneOntologyMolecularFunction	immunoglobulin binding	FCGR2C FCGR2B	6.68e-03	36	68	2	GO:0019865
GeneOntologyMolecularFunction	phospholipase activity	PNPLA6 PLA2G4D EDNRA	6.94e-03	114	68	3	GO:0004620
GeneOntologyMolecularFunction	ubiquitin-like protein ligase binding	JAK1 MAGEA6 TSG101 HERC2 CBS	7.46e-03	358	68	5	GO:0044389
GeneOntologyMolecularFunction	organophosphate ester transmembrane transporter activity	SLC37A1 SLC37A2	7.81e-03	39	68	2	GO:0015605
GeneOntologyBiologicalProcess	renal protein absorption	EDNRA EDNRB GSN	7.38e-06	12	68	3	GO:0097017
GeneOntologyBiologicalProcess	neuron projection development	FLNA KIRREL3 NMNAT2 CPNE9 MAP1A FCGR2B FAT3 WNT7B ADGRB1 ADGRB3 CPNE1 RUNX3 CPNE5 EDNRA	6.38e-05	1285	68	14	GO:0031175
GeneOntologyBiologicalProcess	response to metal ion	CPNE8 CPNE9 ACO1 CPNE1 XDH IREB2 CPNE5 GSN	6.46e-05	415	68	8	GO:0010038
GeneOntologyBiologicalProcess	neuron development	FLNA KIRREL3 NMNAT2 CPNE9 MAP1A FCGR2B FAT3 WNT7B ADGRB1 ADGRB3 CPNE1 RUNX3 CPNE5 EDNRA EDNRB	6.66e-05	1463	68	15	GO:0048666
GeneOntologyBiologicalProcess	cellular response to metal ion	CPNE8 CPNE9 CPNE1 IREB2 CPNE5 GSN	8.46e-05	219	68	6	GO:0071248
GeneOntologyBiologicalProcess	citrate metabolic process	ACO1 IREB2	1.06e-04	5	68	2	GO:0006101
GeneOntologyBiologicalProcess	cellular response to calcium ion	CPNE8 CPNE9 CPNE1 CPNE5	2.05e-04	88	68	4	GO:0071277
GeneOntologyBiologicalProcess	tricarboxylic acid cycle	ACO1 IREB2 SDHA	2.08e-04	35	68	3	GO:0006099
GeneOntologyBiologicalProcess	kidney development	FREM2 KIRREL3 FRAS1 TRAF3IP1 WNT7B EDNRA EDNRB	2.21e-04	372	68	7	GO:0001822
GeneOntologyBiologicalProcess	hexose phosphate transport	SLC37A1 SLC37A2	2.23e-04	7	68	2	GO:0015712
GeneOntologyBiologicalProcess	glucose-6-phosphate transport	SLC37A1 SLC37A2	2.23e-04	7	68	2	GO:0015760
MousePheno	cryptophthalmos	FREM2 FRAS1	5.06e-05	3	58	2	MP:0005242
MousePheno	absent photoreceptor outer segment	PDE6A CLCN7 OAT	5.29e-05	18	58	3	MP:0008585
MousePheno	abnormal respiratory system physiology	JAK1 FLNA NMNAT2 FRAS1 CLCN7 FCGR2B ACKR3 FAT3 WNT7B RUNX3 EDNRA EDNRB GSN	6.06e-05	897	58	13	MP:0002133
MousePheno	abnormal photoreceptor outer segment number	PDE6A CLCN7 OAT	7.35e-05	20	58	3	MP:0020815
MousePheno	increased intestinal iron level	IREB2 HEPH	1.01e-04	4	58	2	MP:0020369
MousePheno	fetal bleb	FREM2 FRAS1	1.01e-04	4	58	2	MP:0008856
MousePheno	abnormal respiration	JAK1 NMNAT2 FRAS1 CLCN7 ACKR3 FAT3 WNT7B RUNX3 EDNRA EDNRB	1.55e-04	598	58	10	MP:0001943
Domain	Copine	CPNE8 CPNE9 CPNE1 CPNE5	1.77e-08	9	66	4	PF07002
Domain	Copine	CPNE8 CPNE9 CPNE1 CPNE5	1.77e-08	9	66	4	IPR010734
Domain	Endthln_rcpt	EDNRA EDNRB	1.23e-05	2	66	2	IPR000499
Domain	Aconitase/IRP2	ACO1 IREB2	1.23e-05	2	66	2	IPR006249
Domain	-	ACO1 IREB2	3.68e-05	3	66	2	3.40.1060.10
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB3	3.68e-05	3	66	2	IPR008077
Domain	-	ACO1 IREB2	3.68e-05	3	66	2	3.20.19.10
Domain	Acoase/IPM_deHydtase	ACO1 IREB2	3.68e-05	3	66	2	IPR015937
Domain	Acnase/IPM_dHydase_lsu_aba_1/3	ACO1 IREB2	3.68e-05	3	66	2	IPR015931
Domain	Aconitase/IPMdHydase_lsu_aba_2	ACO1 IREB2	3.68e-05	3	66	2	IPR015932
Domain	AconitaseA/IPMdHydase_ssu_swvl	ACO1 IREB2	3.68e-05	3	66	2	IPR000573
Domain	ACONITASE_1	ACO1 IREB2	3.68e-05	3	66	2	PS00450
Domain	Aconitase/3IPM_dehydase_swvl	ACO1 IREB2	3.68e-05	3	66	2	IPR015928
Domain	Aconitase_C	ACO1 IREB2	3.68e-05	3	66	2	PF00694
Domain	Aconitase	ACO1 IREB2	3.68e-05	3	66	2	PF00330
Domain	Aconitase_4Fe-4S_BS	ACO1 IREB2	3.68e-05	3	66	2	IPR018136
Domain	-	ACO1 IREB2	3.68e-05	3	66	2	3.30.499.10
Domain	ACONITASE_2	ACO1 IREB2	3.68e-05	3	66	2	PS01244
Domain	Acoase/IPM_deHydtase_lsu_aba	ACO1 IREB2	3.68e-05	3	66	2	IPR001030
Domain	Sugar_P_transporter	SLC37A1 SLC37A2	7.35e-05	4	66	2	IPR000849
Domain	C2	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	9.97e-05	131	66	5	PF00168
Domain	2Fe2S_fd_BS	XDH NDUFS1	1.22e-04	5	66	2	IPR006058
Domain	2FE2S_FER_1	XDH NDUFS1	1.22e-04	5	66	2	PS00197
Domain	C2	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	1.23e-04	137	66	5	SM00239
Domain	C2	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	1.46e-04	142	66	5	PS50004
Domain	-	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	1.77e-04	148	66	5	2.60.40.150
Domain	Fer2	XDH NDUFS1	1.83e-04	6	66	2	PF00111
Domain	2FE2S_FER_2	XDH NDUFS1	1.83e-04	6	66	2	PS51085
Domain	2Fe-2S_ferredoxin-type	XDH NDUFS1	1.83e-04	6	66	2	IPR001041
Domain	VWFA	CPNE8 CPNE9 CPNE1 CPNE5	2.02e-04	82	66	4	PS50234
Domain	VWA	CPNE8 CPNE9 CPNE1 CPNE5	2.22e-04	84	66	4	SM00327
Domain	C2_dom	CPNE8 CPNE9 CPNE1 PLA2G4D CPNE5	2.85e-04	164	66	5	IPR000008
Domain	Calx_beta	FREM2 FRAS1	3.40e-04	8	66	2	SM00237
Domain	VWF_A	CPNE8 CPNE9 CPNE1 CPNE5	4.16e-04	99	66	4	IPR002035
Domain	Calx_beta	FREM2 FRAS1	4.36e-04	9	66	2	IPR003644
Domain	Calx-beta	FREM2 FRAS1	4.36e-04	9	66	2	PF03160
Domain	IG_FLMN	FLNA TRIM71	5.43e-04	10	66	2	SM00557
Domain	Filamin	FLNA TRIM71	6.63e-04	11	66	2	PF00630
Domain	GAIN_dom_N	ADGRB1 ADGRB3	6.63e-04	11	66	2	IPR032471
Domain	FILAMIN_REPEAT	FLNA TRIM71	6.63e-04	11	66	2	PS50194
Domain	Filamin/ABP280_rpt	FLNA TRIM71	6.63e-04	11	66	2	IPR001298
Domain	GAIN	ADGRB1 ADGRB3	6.63e-04	11	66	2	PF16489
Domain	Filamin/ABP280_repeat-like	FLNA TRIM71	6.63e-04	11	66	2	IPR017868
Domain	Beta-grasp_dom	XDH NDUFS1	1.09e-03	14	66	2	IPR012675
Domain	-	XDH NDUFS1	1.09e-03	14	66	2	3.10.20.30
Domain	CBS	CLCN7 CBS	1.43e-03	16	66	2	SM00116
Domain	TSP_1	CILP ADGRB1 ADGRB3	1.44e-03	63	66	3	PF00090
Domain	TSP1	CILP ADGRB1 ADGRB3	1.57e-03	65	66	3	SM00209
Domain	TSP1_rpt	CILP ADGRB1 ADGRB3	1.57e-03	65	66	3	IPR000884
Domain	TSP1	CILP ADGRB1 ADGRB3	1.57e-03	65	66	3	PS50092
Domain	Acyl_Trfase/lysoPLipase	PNPLA6 PLA2G4D	1.62e-03	17	66	2	IPR016035
Domain	CBS_dom	CLCN7 CBS	2.24e-03	20	66	2	IPR000644
Domain	CBS	CLCN7 CBS	2.24e-03	20	66	2	PF00571
Domain	CBS	CLCN7 CBS	2.24e-03	20	66	2	PS51371
Domain	MFS_1	SLC37A1 SLC37A2 SLC16A11	2.56e-03	77	66	3	PF07690
Domain	MFS	SLC37A1 SLC37A2 SLC16A11	2.56e-03	77	66	3	IPR011701
Domain	HormR	ADGRB1 ADGRB3	3.50e-03	25	66	2	SM00008
Pubmed	The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans.	CPNE8 CPNE9 CPNE1 CPNE5	1.67e-09	9	68	4	9430674
Pubmed	Biochemical characterization of copine: a ubiquitous Ca2+-dependent, phospholipid-binding protein.	CPNE8 CPNE9 CPNE1	7.15e-09	3	68	3	11123945
Pubmed	Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina.	ACO1 IREB2 HEPH	2.86e-08	4	68	3	15354085
Pubmed	HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.	ACO1 IREB2 HERC2	1.42e-07	6	68	3	24778179
Pubmed	Subcellular localization of iron regulatory proteins to Golgi and ER membranes.	ACO1 IREB2	3.77e-06	2	68	2	16144863
Pubmed	Associations of EDNRA and EDNRB Polymorphisms with Intracerebral Hemorrhage.	EDNRA EDNRB	3.77e-06	2	68	2	31150867
Pubmed	Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.	ACO1 IREB2	3.77e-06	2	68	2	15866737
Pubmed	A regulated RNA binding protein also possesses aconitase activity.	ACO1 IREB2	3.77e-06	2	68	2	1946430
Pubmed	Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.	ACO1 IREB2	3.77e-06	2	68	2	16283625
Pubmed	Facial hyperalgesia due to direct action of endothelin-1 in the trigeminal ganglion of mice.	EDNRA EDNRB	3.77e-06	2	68	2	29570803
Pubmed	Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.	ACO1 IREB2	3.77e-06	2	68	2	38301068
Pubmed	Endothelin receptor heteromerization inhibits β-arrestin function in HEK293 cells.	EDNRA EDNRB	3.77e-06	2	68	2	32744876
Pubmed	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	ACO1 IREB2	3.77e-06	2	68	2	14726953
Pubmed	Identification of a novel role for endothelins within the oviduct.	EDNRA EDNRB	3.77e-06	2	68	2	20357223
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	3.77e-06	2	68	2	2531080
Pubmed	Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.	EDNRA EDNRB	3.77e-06	2	68	2	16962346
Pubmed	Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.	ACO1 IREB2	3.77e-06	2	68	2	17200797
Pubmed	Identification of two novel CAKUT-causing genes by massively parallel exon resequencing of candidate genes in patients with unilateral renal agenesis.	FREM2 FRAS1	3.77e-06	2	68	2	21900877
Pubmed	The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea.	EDNRA EDNRB	3.77e-06	2	68	2	17607529
Pubmed	Patients with Leber hereditary optic neuropathy fail to compensate impaired oxidative phosphorylation.	NDUFS1 SDHA	3.77e-06	2	68	2	19836344
Pubmed	Role of ET(A) receptors in the vasoconstriction induced by endothelin-1 in subcutaneous small arteries of normotensive subjects and hypertensive patients.	EDNRA EDNRB	3.77e-06	2	68	2	11930911
Pubmed	In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.	ACO1 IREB2	3.77e-06	2	68	2	19533074
Pubmed	Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.	ACO1 IREB2	3.77e-06	2	68	2	15831703
Pubmed	Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency.	SLC37A1 SLC37A2	3.77e-06	2	68	2	11112347
Pubmed	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	ACO1 IREB2	3.77e-06	2	68	2	25771171
Pubmed	Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.	ACO1 IREB2	3.77e-06	2	68	2	15208438
Pubmed	Expression of endothelin receptor subtypes in bronchial tumors.	EDNRA EDNRB	3.77e-06	2	68	2	20043107
Pubmed	Modulation of endothelin receptors in the failing right ventricle of the heart and vasculature of the lung in human pulmonary arterial hypertension.	EDNRA EDNRB	3.77e-06	2	68	2	24582810
Pubmed	Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.	ACO1 IREB2	3.77e-06	2	68	2	8262972
Pubmed	Functional diversity of endothelin pathways in human lung fibroblasts may be based on structural diversity of the endothelin receptors.	EDNRA EDNRB	3.77e-06	2	68	2	14636059
Pubmed	Combined knockout of collecting duct endothelin A and B receptors causes hypertension and sodium retention.	EDNRA EDNRB	3.77e-06	2	68	2	18784261
Pubmed	Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.	ACO1 IREB2	3.77e-06	2	68	2	16503547
Pubmed	Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.	ACO1 IREB2	3.77e-06	2	68	2	21566147
Pubmed	Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.	ACO1 IREB2	3.77e-06	2	68	2	15938636
Pubmed	Selective in vivo antagonism of endothelin receptors in transforming growth factor-beta1 transgenic mice that mimic the vascular pathology of Alzheimer's disease.	EDNRA EDNRB	3.77e-06	2	68	2	20628431
Pubmed	Endothelin ETA and ETB receptor expression in the human trigeminal ganglion.	EDNRA EDNRB	3.77e-06	2	68	2	16816835
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	3.77e-06	2	68	2	9516136
Pubmed	Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries.	EDNRA EDNRB	3.77e-06	2	68	2	14729387
Pubmed	Association between migraine and endothelin type A receptor (ETA -231 A/G) gene polymorphism.	EDNRA EDNRB	3.77e-06	2	68	2	11376172
Pubmed	Iron regulatory proteins secure mitochondrial iron sufficiency and function.	ACO1 IREB2	3.77e-06	2	68	2	20674864
Pubmed	Molecular characterization and regulation of the human endothelin receptors.	EDNRA EDNRB	3.77e-06	2	68	2	8440682
Pubmed	Excess capacity of the iron regulatory protein system.	ACO1 IREB2	3.77e-06	2	68	2	17604281
Pubmed	Altered expression and signal transduction of endothelin-1 receptors in heritable and idiopathic pulmonary arterial hypertension.	EDNRA EDNRB	3.77e-06	2	68	2	22688668
Pubmed	ETA and ETB receptors are expressed in vascular adventitial fibroblasts.	EDNRA EDNRB	3.77e-06	2	68	2	21949113
Pubmed	Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease.	EDNRA EDNRB	3.77e-06	2	68	2	19299580
Pubmed	Agonist-promoted ubiquitination differentially regulates receptor trafficking of endothelin type A and type B receptors.	EDNRA EDNRB	3.77e-06	2	68	2	25381251
Pubmed	Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.	ACO1 IREB2	3.77e-06	2	68	2	2172968
Pubmed	Effects of endothelin-related gene polymorphisms and aerobic exercise habit on age-related arterial stiffening: a 10-yr longitudinal study.	EDNRA EDNRB	3.77e-06	2	68	2	29097630
Pubmed	Molecular study of 33 families with Fraser syndrome new data and mutation review.	FREM2 FRAS1	3.77e-06	2	68	2	18671281
Pubmed	The contractile effects of endothelins on isolated isthmic segment of human oviduct at the luteal phase of the menstrual cycle.	EDNRA EDNRB	3.77e-06	2	68	2	20401344
Pubmed	Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice.	EDNRA EDNRB	3.77e-06	2	68	2	10198387
Pubmed	Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.	ACO1 IREB2	3.77e-06	2	68	2	22331484
Pubmed	Increased gene expression and production of murine endothelin receptors after birth.	EDNRA EDNRB	3.77e-06	2	68	2	12763050
Pubmed	[Molecular cloning of human endothelin receptors and their expression in vascular endothelial cells and smooth muscle cells].	EDNRA EDNRB	3.77e-06	2	68	2	1291713
Pubmed	Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.	ACO1 IREB2	3.77e-06	2	68	2	7983023
Pubmed	Novel loss of function variants in FRAS1 AND FREM2 underlie renal agenesis in consanguineous families.	FREM2 FRAS1	3.77e-06	2	68	2	32643034
Pubmed	Down-regulation of ETA receptors in ETB receptor-deficient mice.	EDNRA EDNRB	3.77e-06	2	68	2	15838300
Pubmed	Real-time polymerase chain reaction quantification of gene expression levels of murine endothelin-A and endothelin-B receptors: gene expression profiles by the standard curve method.	EDNRA EDNRB	3.77e-06	2	68	2	15838311
Pubmed	Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice.	EDNRA EDNRB	3.77e-06	2	68	2	22365955
Pubmed	Blood pressure regulation by ETA and ETB receptors in conscious, telemetry-instrumented mice and role of ETA in hypertension produced by selective ETB blockade.	EDNRA EDNRB	3.77e-06	2	68	2	16399858
Pubmed	Endothelin receptor pharmacology and function in the mouse: comparison with rat and man.	EDNRA EDNRB	3.77e-06	2	68	2	15838332
Pubmed	Comparison of endothelin-A and endothelin-B receptor distribution visualized by radioligand binding versus immunocytochemical localization using subtype selective antisera.	EDNRA EDNRB	3.77e-06	2	68	2	15838285
Pubmed	Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.	ACO1 IREB2	3.77e-06	2	68	2	18655771
Pubmed	Upregulation of vascular ET(B) receptor gene expression after chronic ET(A) receptor blockade in prediabetic NOD mice.	EDNRA EDNRB	3.77e-06	2	68	2	15838254
Pubmed	High expression of CPNE5 and CPNE9 predicts positive prognosis in multiple myeloma.	CPNE9 CPNE5	3.77e-06	2	68	2	33780365
Pubmed	Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells.	EDNRA EDNRB	3.77e-06	2	68	2	28732172
Pubmed	Ovarian hormones modulate endothelin-1 receptor responses in young women.	EDNRA EDNRB	3.77e-06	2	68	2	29999581
Pubmed	Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.	ACO1 IREB2	3.77e-06	2	68	2	12855587
Pubmed	Targeting endothelin receptors A and B attenuates the inflammatory response and improves locomotor function following spinal cord injury in mice.	EDNRA EDNRB	3.77e-06	2	68	2	24756152
Pubmed	Cloning and chromosomal localization of a human endothelin ETA receptor.	EDNRA EDNRB	3.77e-06	2	68	2	1659806
Pubmed	Endothelin receptor blockade inhibits molecular effectors of Kaposi's sarcoma cell invasion and tumor growth in vivo.	EDNRA EDNRB	3.77e-06	2	68	2	12875994
Pubmed	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	ACO1 IREB2	3.77e-06	2	68	2	15604406
Pubmed	Up-regulation of endothelin receptors induced by cigarette smoke--involvement of MAPK in vascular and airway hyper-reactivity.	EDNRA EDNRB	3.77e-06	2	68	2	21057729
Pubmed	The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.	ACO1 IREB2	3.77e-06	2	68	2	8041788
Pubmed	Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.	ACO1 IREB2	3.77e-06	2	68	2	38773499
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	FLNA FREM2 CPNE8 TKFC CPNE9 CILP ACO1 CPNE1 TSG101 CPNE5 GSN	6.84e-06	1070	68	11	23533145
Pubmed	Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum.	ACO1 IREB2	1.13e-05	3	68	2	18177727
Pubmed	Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.	ACO1 IREB2	1.13e-05	3	68	2	19965627
Pubmed	Transforming growth factor-β regulates endothelin-1 signaling in the newborn mouse lung during hypoxia exposure.	EDNRA EDNRB	1.13e-05	3	68	2	22287612
Pubmed	ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo.	EDNRA EDNRB	1.13e-05	3	68	2	18524860
Pubmed	ETB receptor polymorphism is associated with airway obstruction.	EDNRA EDNRB	1.13e-05	3	68	2	17470272
Pubmed	TNFα-induced airway smooth muscle cell proliferation depends on endothelin receptor signaling, GM-CSF and IL-6.	EDNRA EDNRB	1.13e-05	3	68	2	27422754
Pubmed	Gene expression of endothelin receptors in replaced rheumatic mitral stenotic valves.	EDNRA EDNRB	1.13e-05	3	68	2	23515723
Pubmed	The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.	ACO1 IREB2	1.13e-05	3	68	2	23395174
Pubmed	Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.	ACO1 IREB2	1.13e-05	3	68	2	22003390
Pubmed	Expression of the Endothelin-axis in the different histologic subtypes of renal cell carcinoma: a tissue microarray analysis.	EDNRA EDNRB	1.13e-05	3	68	2	17203161
Pubmed	Activation of endothelin-1 receptor signaling pathways is associated with neointima formation, neoangiogenesis and irreversible pulmonary artery hypertension in patients with congenital heart disease.	EDNRA EDNRB	1.13e-05	3	68	2	21498912
Pubmed	Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization.	EDNRA EDNRB	1.13e-05	3	68	2	17616673
Pubmed	Overexpression of endothelin-1 and endothelin receptors in the pulmonary arteries of failed Fontan patients.	EDNRA EDNRB	1.13e-05	3	68	2	21356562
Pubmed	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	ACO1 IREB2	1.13e-05	3	68	2	23135277
Pubmed	Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.	EDNRA EDNRB	1.13e-05	3	68	2	11982704
Pubmed	Function and survival of dendritic cells depend on endothelin-1 and endothelin receptor autocrine loops.	EDNRA EDNRB	1.13e-05	3	68	2	15213100
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	1.13e-05	3	68	2	23261299
Pubmed	Polymorphisms in genes of the endothelin system and cerebral small-vessel disease.	EDNRA EDNRB	1.13e-05	3	68	2	16002759
Pubmed	Increased expression of endothelin-1 and its receptors in varicocele: an immunohistochemical study.	EDNRA EDNRB	1.13e-05	3	68	2	21601190
Pubmed	Iron regulatory protein (IRP)-mediated iron homeostasis is critical for neutrophil development and differentiation in the bone marrow.	ACO1 IREB2	1.13e-05	3	68	2	36197975
Pubmed	C-terminus of ETA/ETB receptors regulate endothelin-1 signal transmission.	EDNRA EDNRB	1.13e-05	3	68	2	23436727
Pubmed	Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes.	EDNRA EDNRB	1.13e-05	3	68	2	17660396
Pubmed	New concepts in endothelin control of sodium balance.	EDNRA EDNRB	1.13e-05	3	68	2	21418087
Pubmed	Expression of endothelin-1, endothelin-A, and endothelin-B receptor in human breast cancer and correlation with long-term follow-up.	EDNRA EDNRB	1.13e-05	3	68	2	14519635
GeneFamily	Copines	CPNE8 CPNE9 CPNE1 CPNE5	3.81e-09	9	44	4	829
GeneFamily	Endothelin receptors	EDNRA EDNRB	5.79e-06	2	44	2	225
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB3	1.73e-05	3	44	2	912
GeneFamily	Solute carriers	SLC37A1 SLC39A11 SLC37A2 SLC16A11 SLC7A14	2.62e-03	395	44	5	752
Coexpression	GSE3982_DC_VS_EFF_MEMORY_CD4_TCELL_UP	FCGR2C SEPHS2 CLCN7 ACO1 DAPK1 TSG101	1.31e-05	199	68	6	M5474
Coexpression	GSE7852_LN_VS_THYMUS_TCONV_UP	PNPLA6 PRSS12 ADGRB1 XDH DAPK1 SLC37A2	1.31e-05	199	68	6	M5745
Coexpression	GSE28737_WT_VS_BCL6_KO_FOLLICULAR_BCELL_DN	JAK1 TRAF3IP1 HERC2 EDNRA GSN HDC	1.35e-05	200	68	6	M9374
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_top-relative-expression-ranked_1000	JAK1 CPNE8 ACKR3 FAT3 DGKK ADGRB3 TRIM71 HERC2 SLC7A14 EDNRA EDNRB HDC	9.86e-06	818	68	12	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Npw\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE9 DGKK DYNLRB2 CPNE5 CFAP65	8.40e-07	113	68	5	165de4316059222f33d1e51aeff4554037c0b937
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cpa6_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE8 FRAS1 CPNE9 ACKR3 WNT7B	2.59e-06	142	68	5	84742a7e35bab09ee1cca80cfe120b613d6aed6a
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE8 CPNE9 FAT3 WNT7B CPNE5	5.73e-06	167	68	5	f1ce6e64ebede1f3ef36fe982f46919fd1f814dd
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	KIRREL3 ADGRB3 SORCS3 SYBU SLC7A14	5.89e-06	168	68	5	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	facs-Large_Intestine-Proximal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIRREL3 PNPLA6 MAP1A ADGRB3 CPNE5	6.24e-06	170	68	5	c638dfde9ce30190abbe0caea1c3eb874af09857
ToppCell	3'_v3-bone_marrow-Myeloid_Mac-Erythrophagocytic_macrophages\|bone_marrow / Manually curated celltypes from each tissue	SEPHS2 CPNE9 ACKR3 SLC37A2 EDNRB	8.24e-06	180	68	5	daf69a548ed7c6f285a6adcff00f99aa22f9d6a5
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	KIRREL3 CILP ACKR3 ADGRB3 GSN	9.91e-06	187	68	5	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	RA\|World / Chamber and Cluster_Paper	CPNE8 NMNAT2 FRAS1 EDNRA GSN	1.18e-05	194	68	5	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	CPNE8 NMNAT2 FRAS1 CPNE5 EDNRA	1.18e-05	194	68	5	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	severe-NK_CD56bright\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK1 FRAS1 PRSS12 RUNX3 GSN	1.37e-05	200	68	5	82818ab1796fdd0b8be02b341818897595eed841
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Whrn_Tox2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE8 FRAS1 PRSS12 WNT7B	6.80e-05	143	68	4	36ce6f163fb33141c86288086c354b91853fad25
ToppCell	facs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA P2RY10 XDH RUNX3	9.07e-05	154	68	4	1e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT3 P2RY10 RUNX3 HDC	9.30e-05	155	68	4	c648512305166d2a2f0e284c127bc802af908071
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FRAS1 CPNE9 FAT3 WNT7B	9.77e-05	157	68	4	5aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Batf3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE8 FRAS1 PRSS12 WNT7B	9.77e-05	157	68	4	921805932f7974d37aed547861d555b07f30aba6
ToppCell	Control-Epithelial_airway\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FREM2 WNT7B SLC16A11 CFAP65	1.00e-04	158	68	4	35aee1c3b92169e73569331022833cb44ab7e7e8
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DYNLRB2 CPNE5 HDC CFAP65	1.03e-04	159	68	4	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE9 FAT3 WNT7B CPNE5	1.05e-04	160	68	4	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIRREL3 CPNE1 GSN HDC	1.16e-04	164	68	4	8e6dbddacd56a07769163813e3ebfad13302bb62
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	FLNA FAT3 CPNE5 EDNRB	1.18e-04	165	68	4	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	CILP FAT3 ADGRB3 TRIM71	1.18e-04	165	68	4	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	facs-Marrow-T_cells-18m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.21e-04	166	68	4	fab4da2537904ad114218f720e18a600f14a00a1
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A ADGRB3 HEPH EDNRA	1.24e-04	167	68	4	e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A ADGRB3 HEPH EDNRA	1.24e-04	167	68	4	7cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1A ADGRB3 HEPH EDNRA	1.24e-04	167	68	4	bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.27e-04	168	68	4	3611605114f6b668b44728d6563cd02389e106af
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	JAK1 SEPHS2 P2RY10 RUNX3	1.27e-04	168	68	4	187b98664843a304406f086ea696adbf32283d07
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.30e-04	169	68	4	f38b52972a6c492ce2fd520a26bb3fc8db23bf85
ToppCell	facs-Marrow-Granulocytes-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.30e-04	169	68	4	ee1969755180df58d32904e2bb4192da9373d03e
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.30e-04	169	68	4	5320da1d61806b53e0bd96bbdfdb8fd69246681b
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS12 GYPA P2RY10 CPNE5	1.30e-04	169	68	4	c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	KIRREL3 ADGRB3 CBS GSN	1.30e-04	169	68	4	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CLCN7 CILP FAT3 EDNRA	1.33e-04	170	68	4	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CPNE8 FRAS1 FAT3 WNT7B	1.33e-04	170	68	4	67415b098e8ba815b501e557192a9f2b10ee995a
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	JAK1 PRSS12 P2RY10 RUNX3	1.33e-04	170	68	4	8e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.36e-04	171	68	4	ab21f20ec041cbaacccbd7da4dccdb77ec8bc5c6
ToppCell	facs-Marrow-Granulocytes\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.36e-04	171	68	4	1701dedf0c18751db6c9fee3d93fff150ed0e17f
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.36e-04	171	68	4	97ad2cfff568a9d006ab1d2e6e00946ee4e3beb3
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS12 GYPA P2RY10 CPNE5	1.36e-04	171	68	4	20ac3de9c164b409b70a30a8b6544ea491ef7c0e
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA MAP1A CPNE5 EDNRB	1.36e-04	171	68	4	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNA MAP1A CPNE5 EDNRB	1.36e-04	171	68	4	09e653973962fb884878089d281f0947f7a285f6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE6A FCGR2B SLC39A11 HDC	1.39e-04	172	68	4	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PDE6A FCGR2B SLC39A11 HDC	1.39e-04	172	68	4	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.42e-04	173	68	4	0f9784b30c81a4a4940e0623cec60d596e9985d2
ToppCell	facs-Marrow-T_cells-18m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.42e-04	173	68	4	60f79e0698a7cf7516690fb20f1b82ee46547699
ToppCell	COVID-19-Heart-Neuronal\|Heart / Disease (COVID-19 only), tissue and cell type	KIRREL3 ADGRB3 SORCS3 SYBU	1.42e-04	173	68	4	6fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT3 P2RY10 RUNX3 HDC	1.42e-04	173	68	4	2cba41c3d9d3076f703115d19729073a3ac3feb6
ToppCell	E16.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FAT3 P2RY10 RUNX3 HDC	1.42e-04	173	68	4	11d69a4ab4a87b8820cd3bd204de8c4124450a90
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	ACKR3 FAT3 ADGRB1 EDNRA	1.45e-04	174	68	4	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NMNAT2 MAP1A STKLD1 EDNRA	1.45e-04	174	68	4	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	(5)_Dendritic_cell-(50)_cDC2\|(5)_Dendritic_cell / shred on Cell_type and subtype	FCGR2B RUNX3 GSN	1.48e-04	67	68	3	41566121ac0e97a7df4fc83fc196160b700d3639
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PRSS12 DYNLRB2 SORCS3 CPNE5	1.48e-04	175	68	4	c227fc5d1ccb69b82a96a6354913cafaf27d0eec
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	JAK1 PRSS12 P2RY10 RUNX3	1.48e-04	175	68	4	f949613ee45f5d950578c512d197716855118d18
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4\|TCGA-Lung / Sample_Type by Project: Shred V9	FCGR2C NMNAT2 CILP FCGR2B	1.52e-04	176	68	4	0923b01137d6f9956ca815b41102c81e82624065
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACKR3 XDH HEPH EDNRB	1.52e-04	176	68	4	eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.55e-04	177	68	4	065bebd22031f143e90a407f952b444a3f8818c7
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 ADGRB3 HEPH EDNRA	1.55e-04	177	68	4	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	droplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B SLC16A11 STKLD1 CFAP65	1.55e-04	177	68	4	7ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCGR2B P2RY10 SLC37A2 RUNX3	1.55e-04	177	68	4	3a150dcaefa342d49968b42c7cdb1fbb633adcd0
ToppCell	NS-critical-d_07-13-Lymphoid-B_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FCGR2B P2RY10 RUNX3 CPNE5	1.55e-04	177	68	4	d4db058c09012ec9fbde61277a9f86d9956de8fc
ToppCell	BAL-Severe-cDC_3\|Severe / Compartment, Disease Groups and Clusters	FCGR2B ADGRB3 CPNE5 GSN	1.55e-04	177	68	4	939487a05311b66edfc3f44a7955fbf25266d6bf
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FCGR2B P2RY10 SLC37A2 RUNX3	1.55e-04	177	68	4	c9e5820ff0bc7ad1adcfb2651713fdfc58bced56
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KIRREL3 PRSS12 CPNE5 HDC	1.55e-04	177	68	4	86c41d262142eeaa95ea7fa6668169eb1bb2953f
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 ADGRB3 HEPH EDNRA	1.55e-04	177	68	4	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TKFC ACO1 OAT HDC	1.55e-04	177	68	4	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	facs-Marrow-Granulocytes-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.55e-04	177	68	4	eb304f20aab075bd17aa3aef819386c0e1a235bd
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B SLC16A11 STKLD1 CFAP65	1.55e-04	177	68	4	092a345cb802f183322aa5542341ba2d96d4f06a
ToppCell	droplet-Fat-SCAT-30m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIRREL3 CILP ACKR3 GSN	1.58e-04	178	68	4	5cf12927f0756c4d8a289fe4308d736382e6212e
ToppCell	control-NK_CD56bright\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	JAK1 FRAS1 RUNX3 GSN	1.58e-04	178	68	4	f3d0bc9a39ed94785676f10c285c5b031bc93aae
ToppCell	control-Epithelial-Secretory-diff\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	KIRREL3 STKLD1 EDNRA	1.61e-04	69	68	3	2c1eb6b358c323b4b6a642f473068681987a9e91
ToppCell	droplet-Liver-LIVER-NPC-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 TKFC OAT ECI1	1.62e-04	179	68	4	10baf575f06f9a15384bcdc751446b4670acf942
ToppCell	droplet-Bladder-nan-24m-Epithelial-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE6A CILP FAT3 GSN	1.62e-04	179	68	4	dfd9d29281510d32f1a2e8336d2e58ef496cfd1d
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FREM2 FRAS1 DAPK1 TRIM71	1.62e-04	179	68	4	815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCell	15-Distal-Epithelial-Neuroendocrine\|Distal / Age, Tissue, Lineage and Cell class	CPNE9 SYBU PLA2G4D SLC7A14	1.62e-04	179	68	4	bc04789f0fbd293fdcea66acba8cf227af251b7a
ToppCell	(05)_Ciliated-(4)_1wkpi\|(05)_Ciliated / shred by cell type and Timepoint	CPNE8 FCGR2B HDC CFAP65	1.65e-04	180	68	4	85fc9b164147b28545e2397d32302eea03ef6346
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 PRSS12 XDH OAT	1.65e-04	180	68	4	b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCell	facs-Spleen-nan-3m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JAK1 P2RY10 CPNE1 GSN	1.65e-04	180	68	4	87fb1fdbc49c808bb5f6fe9fb747057b45fa78d0
ToppCell	control-Lymphoid-B_cell\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FCGR2B P2RY10 RUNX3 CPNE5	1.69e-04	181	68	4	e414303bb90e5fe7b667c2acf9a50f8694b90e54
ToppCell	P03-Epithelial-airway_epithelial_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TRAF3IP1 DYNLRB2 SLC16A11 CFAP65	1.69e-04	181	68	4	1ea21d860d4d7abab3e21e130a16d044006656ee
ToppCell	droplet-Liver-LIVER-NPC-1m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 TKFC OAT ECI1	1.69e-04	181	68	4	48d28eafbb5f4b141deeb0bf020dfca39e7be7a5
ToppCell	P03-Epithelial-airway_epithelial_cell-club_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TRAF3IP1 DYNLRB2 SLC16A11 CFAP65	1.69e-04	181	68	4	60a91587c59029a34e7bec1255083337fe21b72a
ToppCell	droplet-Liver-LIVER-NPC-1m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEPHS2 TKFC OAT ECI1	1.69e-04	181	68	4	0a44781cc34535f061812d1370f748b7bbdef17b
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA DYNLRB2 EDNRA CFAP65	1.69e-04	181	68	4	c1b1e62440805800a3a600b1ddd79be1c9762598
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FRAS1 FAT3 ADGRB3 EDNRA	1.69e-04	181	68	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIRREL3 CPNE9 MAP1A GSN	1.72e-04	182	68	4	9bbe8062aa562dc3b9c299581faf6ebbcb72a9f7
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CILP DYNLRB2 HDC CFAP65	1.72e-04	182	68	4	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	NS-control-d_0-4-Lymphoid-B_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FCGR2B P2RY10 RUNX3 CPNE5	1.72e-04	182	68	4	4b9b55154a79992112c1c467e8752c3cdbb541d9
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CILP DYNLRB2 HDC CFAP65	1.72e-04	182	68	4	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	3'-Adult-LargeIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC37A1 PRSS12 HEPH GSN	1.72e-04	182	68	4	b4f347fb684f6840c166d7473f3f56389f69c14b
ToppCell	systemic_lupus_erythematosus-treated-Myeloid-plasmacytoid_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	KIRREL3 CPNE9 MAP1A GSN	1.72e-04	182	68	4	4602a98df7045e2c70b7560abfba9b444fbd5d30
ToppCell	droplet-Lung-LUNG-30m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B DYNLRB2 SLC16A11 STKLD1	1.76e-04	183	68	4	3991830726d05cf19606d540de04093985b7bdeb
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_vein-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	KIRREL3 CPNE8 ACKR3 ADGRB3	1.76e-04	183	68	4	c1297d8eddfc7132e84ceef14f01b6281f9d0f6a
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WNT7B DYNLRB2 SLC16A11 STKLD1	1.76e-04	183	68	4	cc844f54c7564bf432b179ca63bc7c4b9b8cfdd9
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 FAT3 DGKK	1.80e-04	184	68	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OAT SLC16A11 SYBU GSN	1.80e-04	184	68	4	c2ca984551baf4becbefbe58bd1889828542b045
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 FAT3 DGKK	1.80e-04	184	68	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 FRAS1 FAT3 DGKK	1.80e-04	184	68	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Marrow-nan-21m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA XDH GSN HDC	1.80e-04	184	68	4	d071f53ad9e957dc0f8ae9c53aaa31cfebcf815e
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CILP ACKR3 EDNRB GSN	1.83e-04	185	68	4	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FREM2 DYNLRB2 SLC37A2 CFAP65	1.83e-04	185	68	4	05bc89a566b0db90ae06506e067190a4739a0974
Drug	DL-arginine	VMP1 TKFC ACO1 XDH IREB2 OAT CBS EDNRA EDNRB HDC	7.27e-08	344	68	10	CID000000232
Drug	C04226	ACO1 XDH IREB2	1.41e-06	8	68	3	CID000151255
Drug	3-methylitaconate	ACO1 XDH IREB2	1.41e-06	8	68	3	CID006438940
Drug	ferric ammonium citrate	ACO1 XDH IREB2 SDHA	2.79e-06	33	68	4	CID000014457
Drug	arginine hydroxamate	ACO1 IREB2 OAT	3.01e-06	10	68	3	CID000151275
Drug	Cocaine	JAK1 KIRREL3 CPNE8 FRAS1 SPG7 MAP1A CLCN7 SLC39A11 XDH SORCS3 SYBU EDNRA EDNRB GSN HDC	5.94e-06	1314	68	15	ctd:D003042
Drug	pyrazinoic acid	ACO1 XDH IREB2	7.13e-06	13	68	3	CID000001047
Drug	Bosentan	EDNRA EDNRB	8.79e-06	2	68	2	DB00559
Drug	TAK 044	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C088196
Drug	6-bromo-2,3-dihydrobenzofuran	EDNRA EDNRB	8.79e-06	2	68	2	CID011252616
Drug	Sitaxentan	EDNRA EDNRB	8.79e-06	2	68	2	DB06268
Drug	A 182086	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C467893
Drug	1H-Indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1S,2R,3S)-	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C087551
Drug	IRL 1620	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C074308
Drug	PD 156252	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C106950
Drug	enrasentan	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C098288
Drug	PD 145065	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C082887
Drug	LU 224332	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C113044
Drug	L-671,776	EDNRA EDNRB	8.79e-06	2	68	2	CID000122853
Drug	p-nitrophenylhydroxylamine	ACO1 IREB2	8.79e-06	2	68	2	CID005486551
Drug	tezosentan	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C120582
Drug	spirodihydrobenzofuranlactam VI	EDNRA EDNRB	8.79e-06	2	68	2	CID000469820
Drug	J 104132	EDNRA EDNRB	8.79e-06	2	68	2	ctd:C119319
Drug	Alloxan	XDH EDNRA SDHA EDNRB	1.08e-05	46	68	4	ctd:D000496
Drug	AC1O7EMV	ACO1 XDH IREB2	2.01e-05	18	68	3	CID005460650
Drug	AC1L1EVQ	ACO1 IREB2 ECI1	2.39e-05	19	68	3	CID000002970
Drug	Ipratropium bromide [22254-24-6]; Up 200; 9.8uM; HL60; HG-U133A	FLNA PNPLA6 CLCN7 DOLK CPNE1 RUNX3	2.50e-05	194	68	6	1769_UP
Drug	WS009A	EDNRA EDNRB	2.63e-05	3	68	2	CID000131948
Drug	Pd164333	EDNRA EDNRB	2.63e-05	3	68	2	CID005311351
Drug	2-nitrobenzoyl chloride	EDNRA EDNRB	2.63e-05	3	68	2	CID000011875
Drug	E106E	EDNRA EDNRB	2.63e-05	3	68	2	CID000026761
Drug	pyrazolinone	EDNRA EDNRB	2.63e-05	3	68	2	CID000351317
Drug	2-ethylacetanilide	EDNRA EDNRB	2.63e-05	3	68	2	CID000036332
Drug	ZD 2574	EDNRA EDNRB	2.63e-05	3	68	2	ctd:C415840
Drug	myriceric acid C	EDNRA EDNRB	2.63e-05	3	68	2	CID005274625
Drug	NSC 90	EDNRA EDNRB	2.63e-05	3	68	2	CID000073811
Drug	Methionine sulfoximine (L) [15985-39-4]; Down 200; 22.2uM; MCF7; HT_HG-U133A	FRAS1 CILP GYPA WNT7B RUNX3 GSN	2.65e-05	196	68	6	4151_DN
Drug	muramic acids	ACO1 GYPA IREB2	2.80e-05	20	68	3	CID000092864
Drug	BFNU	ACO1 IREB2	5.25e-05	4	68	2	CID000096886
Drug	4-phenoxybutyric acid	EDNRA EDNRB	5.25e-05	4	68	2	CID000022741
Drug	sarafotoxins s6	EDNRA EDNRB	5.25e-05	4	68	2	ctd:C057354
Drug	indane-2-carboxylic acid	EDNRA EDNRB	5.25e-05	4	68	2	CID000575777
Drug	2-hydroxyisonicotinate	ACO1 IREB2	5.25e-05	4	68	2	CID000280756
Drug	Cicloral	ACO1 IREB2	5.25e-05	4	68	2	CID000012628
Drug	Clofibric Acid	CPNE8 FCGR2B ACO1 XDH OAT ECI1 CBS NDUFS1 SDHA HDC	5.65e-05	727	68	10	ctd:D002995
Drug	p-nitroaniline	ACO1 XDH IREB2 ECI1	5.75e-05	70	68	4	CID000007475
Drug	nitrofen	FREM2 FRAS1 CLCN7 WNT7B EDNRA EDNRB	7.62e-05	237	68	6	ctd:C007350
Drug	ferrous ammonium sulfate	ACO1 IREB2 HEPH	7.91e-05	28	68	3	CID000024863
Drug	croconic acid	ACO1 IREB2	8.74e-05	5	68	2	CID000546874
Drug	AC1NSY0C	ACO1 IREB2	8.74e-05	5	68	2	CID005372273
Drug	MDL 20,610	FCGR2C FCGR2B	8.74e-05	5	68	2	CID000128209
Drug	pd 151242	EDNRA EDNRB	8.74e-05	5	68	2	CID000132991
Drug	1,5-dihydroxyisoquinoline	EDNRA EDNRB	8.74e-05	5	68	2	ctd:C095653
Drug	Et-(16-21)	EDNRA EDNRB	8.74e-05	5	68	2	CID000129432
Drug	p-nitroacetanilide	ACO1 IREB2	8.74e-05	5	68	2	CID000007691
Drug	L015040	EDNRA EDNRB	8.74e-05	5	68	2	CID004574540
Drug	CpMo	PNPLA6 SDHA	8.74e-05	5	68	2	CID000075644
Drug	1,3-difluoroacetone	ACO1 IREB2	8.74e-05	5	68	2	CID000228397
Drug	butynediol	EDNRA EDNRB	8.74e-05	5	68	2	CID000008066
Drug	2-phenylethenesulfonamide	EDNRA EDNRB	8.74e-05	5	68	2	CID000257501
Drug	Be 18257a	EDNRA EDNRB	8.74e-05	5	68	2	CID000197302
Drug	1,3-difluoro-2-propanol	ACO1 IREB2	8.74e-05	5	68	2	CID000067985
Drug	fluoroacetaldehyde	ACO1 IREB2	8.74e-05	5	68	2	CID000073766
Drug	SB 234551	EDNRA EDNRB	8.74e-05	5	68	2	CID005311425
Drug	gliftor	ACO1 IREB2	8.74e-05	5	68	2	CID000197109
Drug	cinchoninic acid	ACO1 IREB2	8.74e-05	5	68	2	CID000010243
Drug	Fe4S4	ACO1 XDH IREB2 CBS NDUFS1 SDHA	1.00e-04	249	68	6	CID000439317
Drug	superoxide	FCGR2C FCGR2B ACO1 XDH IREB2 NDUFS1 HEPH SDHA	1.04e-04	490	68	8	CID000520535
Drug	yersiniabactin	TKFC ACO1 IREB2	1.08e-04	31	68	3	CID005462519
Drug	sodium nitroprusside	PDE6A ACO1 XDH IREB2 EDNRA EDNRB	1.29e-04	261	68	6	CID000045469
Drug	manganese pyrophosphate	ACO1 IREB2	1.31e-04	6	68	2	CID000152037
Drug	TAN-1030A	FCGR2C FCGR2B	1.31e-04	6	68	2	CID009576886
Drug	CGS 27830	EDNRA EDNRB	1.31e-04	6	68	2	CID000190809
Drug	Bq 153	EDNRA EDNRB	1.31e-04	6	68	2	CID000196897
Drug	A-192621	EDNRA EDNRB	1.31e-04	6	68	2	CID005310991
Drug	Bq 928	EDNRA EDNRB	1.31e-04	6	68	2	CID000133071
Drug	R)-3-pyrrolidinecarboxylic acid	EDNRA EDNRB	1.31e-04	6	68	2	CID001501969
Drug	oxalomalic acid	ACO1 IREB2	1.31e-04	6	68	2	CID000439620
Drug	fulvene	SPG7 CBS	1.31e-04	6	68	2	CID000136323
Drug	FE-S CLUSTER	ACO1 IREB2	1.31e-04	6	68	2	CID006416167
Drug	1,1'-azobis(N,N-dimethylformamide	ACO1 GYPA IREB2 CBS NDUFS1	1.69e-04	173	68	5	CID000004278
Drug	L-NMMA	ACO1 XDH IREB2 EDNRA EDNRB	1.74e-04	174	68	5	CID000004366
Drug	19-oxo-11-deoxycorticosterone acetate	EDNRA EDNRB	1.83e-04	7	68	2	ctd:C040168
Drug	Fc nu	ACO1 IREB2	1.83e-04	7	68	2	CID000083807
Drug	isovaline	XDH CBS	1.83e-04	7	68	2	CID000094744
Drug	catecholborane	CBS EDNRA	1.83e-04	7	68	2	CID006327445
Drug	2,1,3-benzothiadiazole	EDNRA EDNRB	1.83e-04	7	68	2	CID000067502
Drug	dibenzocycloheptatriene	EDNRA EDNRB	1.83e-04	7	68	2	CID000067492
Drug	TAN-999	FCGR2C FCGR2B	1.83e-04	7	68	2	CID000130283
Drug	Be 18257b	EDNRA EDNRB	1.83e-04	7	68	2	CID000197303
Drug	AC1MHTIN	FCGR2C FCGR2B	1.83e-04	7	68	2	CID003011133
Drug	2-methylcitric acid	ACO1 IREB2 CBS	2.16e-04	39	68	3	CID000000515
Drug	methylselenic acid	JAK1 OAT ECI1 HEPH EDNRA EDNRB GSN	2.26e-04	412	68	7	ctd:C008493
Drug	clazosentan	EDNRA EDNRB	2.43e-04	8	68	2	CID006433095
Drug	Intravenous Immunoglobulin	FCGR2C FCGR2B	2.43e-04	8	68	2	DB00028
Drug	citrazinic acid	ACO1 IREB2	2.43e-04	8	68	2	CID000007425
Drug	Cyclacillin [3485-14-1]; Up 200; 11.8uM; PC3; HT_HG-U133A	LDB1 CLCN7 CILP XDH CBS	2.81e-04	193	68	5	4536_UP
Drug	Flumethasone [2135-17-3]; Down 200; 9.8uM; PC3; HT_HG-U133A	LDB1 MAP1A CLCN7 TRAF3IP1 WNT7B	2.81e-04	193	68	5	3712_DN
Drug	Decamethonium bromide [541-22-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	MAP1A CLCN7 CILP GYPA RUNX3	2.88e-04	194	68	5	4174_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A	MAP1A CILP SYBU RUNX3 EDNRA	3.02e-04	196	68	5	3965_DN
Disease	hair color	FREM2 KIRREL3 FRAS1 SPG7 WNT7B HERC2 EDNRB	7.55e-06	311	68	7	EFO_0003924
Disease	Cryptophthalmos syndrome	FREM2 FRAS1	1.57e-05	3	68	2	C0265233
Disease	FRASER SYNDROME 1	FREM2 FRAS1	1.57e-05	3	68	2	C4551480
Disease	malaria (is_implicated_in)	FCGR2B GYPA CBS	2.29e-05	24	68	3	DOID:12365 (is_implicated_in)
Disease	Fraser syndrome (implicated_via_orthology)	FREM2 FRAS1	3.13e-05	4	68	2	DOID:0090001 (implicated_via_orthology)
Disease	Polyneuropathy	NMNAT2 PNPLA6	3.13e-05	4	68	2	C0152025
Disease	gut microbiome measurement, bone density	FCGR2C FCGR2B ACKR3 SORCS3	3.24e-05	78	68	4	EFO_0003923, EFO_0007874
Disease	Lateral Sclerosis	PNPLA6 SPG7	5.21e-05	5	68	2	C0154682
Disease	porphyria (implicated_via_orthology)	ACO1 IREB2	5.21e-05	5	68	2	DOID:13268 (implicated_via_orthology)
Disease	Congenital small ears	FREM2 FRAS1 EDNRA	1.17e-04	41	68	3	C0152423
Disease	systemic lupus erythematosus (implicated_via_orthology)	JAK1 FCGR2C FCGR2B	1.35e-04	43	68	3	DOID:9074 (implicated_via_orthology)
Disease	blindness (implicated_via_orthology)	PNPLA6 SLC7A14	1.45e-04	8	68	2	DOID:1432 (implicated_via_orthology)
Disease	Unilateral agenesis of kidney	FREM2 FRAS1	1.45e-04	8	68	2	C0266294
Disease	Polydactyly	FREM2 FRAS1 PNPLA6 TRAF3IP1	1.57e-04	117	68	4	C0152427
Disease	plexin-B2 measurement	FCGR2C FCGR2B	1.86e-04	9	68	2	EFO_0021867
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	1.86e-04	9	68	2	DOID:12365 (implicated_via_orthology)
Disease	hair colour measurement, hair morphology measurement	SPG7 HERC2	3.40e-04	12	68	2	EFO_0007821, EFO_0007822
Disease	hyperhomocysteinemia (biomarker_via_orthology)	CBS EDNRA	3.40e-04	12	68	2	DOID:9279 (biomarker_via_orthology)
Disease	neurodegenerative disease (implicated_via_orthology)	NMNAT2 PNPLA6 RNF41 SDHA	3.57e-04	145	68	4	DOID:1289 (implicated_via_orthology)
Disease	rosacea severity measurement	WNT7B SORCS3 SYBU HERC2	3.76e-04	147	68	4	EFO_0009180
Disease	hematocrit	VMP1 FCGR2C FCGR2B ACO1 WNT7B DGKK EDNRA EDNRB GSN	5.05e-04	1011	68	9	EFO_0004348
Disease	alkaline phosphatase measurement	JAK1 KIRREL3 FCGR2C MAP1A FCGR2B SLC16A11 STKLD1 ECI1 GSN	5.19e-04	1015	68	9	EFO_0004533
Disease	–	FCGR2B GYPA	6.15e-04	16	68	2	611162
Disease	Malaria, susceptibility to	FCGR2B GYPA	6.15e-04	16	68	2	cv:C1970028
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	6.96e-04	17	68	2	EFO_0021969
Disease	urinary bladder cancer (is_implicated_in)	XDH DAPK1 RUNX3	7.30e-04	76	68	3	DOID:11054 (is_implicated_in)
Disease	parahippocampal gyrus volume measurement	FREM2 XDH	7.82e-04	18	68	2	EFO_0010318
Disease	sensorineural hearing loss (implicated_via_orthology)	SLC7A14 EDNRB	8.72e-04	19	68	2	DOID:10003 (implicated_via_orthology)
Disease	portal hypertension (implicated_via_orthology)	EDNRA EDNRB	8.72e-04	19	68	2	DOID:10762 (implicated_via_orthology)
Disease	angiopoietin-1 receptor measurement	KIRREL3 STKLD1	8.72e-04	19	68	2	EFO_0010600
Disease	Malaria	FCGR2B GYPA	9.68e-04	20	68	2	C0024530
Disease	e-selectin measurement	KIRREL3 STKLD1	1.17e-03	22	68	2	EFO_0004575
Disease	Disorder of eye	FREM2 FRAS1 PDE6A OAT	1.47e-03	212	68	4	C0015397
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	1.52e-03	25	68	2	EFO_0021970
Disease	FEV/FEC ratio	FREM2 FCGR2C FRAS1 TRAF3IP1 FCGR2B GYPA IREB2 RUNX3 HDC	1.97e-03	1228	68	9	EFO_0004713
Disease	Myocardial Failure	XDH EDNRA EDNRB	2.12e-03	110	68	3	C1959583
Disease	Congestive heart failure	XDH EDNRA EDNRB	2.12e-03	110	68	3	C0018802
Disease	Heart failure	XDH EDNRA EDNRB	2.12e-03	110	68	3	C0018801
Disease	Left-Sided Heart Failure	XDH EDNRA EDNRB	2.12e-03	110	68	3	C0023212
Disease	Heart Failure, Right-Sided	XDH EDNRA EDNRB	2.12e-03	110	68	3	C0235527
Disease	Heart Decompensation	XDH EDNRA EDNRB	2.12e-03	110	68	3	C1961112

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGGIEAEAVMLGQPI	ACO1	221	P21399
DEVMVYGGVRIVPVE	DAPK1	1121	P53355
VGPAAAVVLVNMVIG	ADGRB1	1096	O14514
VGPAAAVVLVNMVIG	ADGRB3	1026	O60242
PMGIIVAVVTGIAVA	FCGR2B	221	P31994
LAIPEAIGFVMVPFE	EDNRA	216	P25101
VLAVPEAIGFDIITM	EDNRB	231	P24530
VENIMVEEFVEGGPL	JAK1	661	P23458
VGGIETEAVMLGLPV	IREB2	296	P48200
EAAQELMPVVAGAVF	NUP205	1326	Q92621
SIFGDIERIIMPGVV	HDC	56	P19113
PQVLGVMIGAGVAVV	PNPLA6	56	Q8IY17
VMITIDGEEGIPVQV	DGKK	996	Q5KSL6
GVIGTMVVNAEGIPI	DYNLRB2	16	Q8TF09
FVLALMLGALPEVVG	PRSS12	6	P56730
PVVMVGGVLASLGFV	SLC16A11	106	Q8NCK7
AIDVVVMVSGEPLLA	TRAF3IP1	76	Q8TDR0
FIIEEGGKEIMTAAP	FRAS1	2411	Q86XX4
GIAITPDGMIVVVDF	TRIM71	846	Q2Q1W2
KAIVFEIMEAGEPTG	MAP1A	1096	P78559
VFGIELMEVDPIGHV	MAGEA6	161	P43360
DPVDFFLLVVVVGMV	DOLK	221	Q9UPQ8
DVMVVGEPTLMGGEF	LDB1	336	Q86U70
ENPEVGGLMAVLAVI	HERC2	2196	O95714
DFGEVSVSPMIGVVA	CFAP65	1481	Q6ZU64
APEIFVGEQLIVMEG	FREM2	1066	Q5SZK8
TIHEIPVFIAMGVVG	CLCN7	371	P51798
PMGIIVAVVTGIAVA	FCGR2C	221	P31995
EIVFPLDMGIVGHVA	PDE6A	131	P16499
GGFFVAVIERVEMPT	NSUN5P2	231	Q63ZY6
LSFVVPGAIVAAMGI	SLC37A1	221	P57057
FIVPGIITAVMGVIT	SLC37A2	211	Q8TED4
RVLVEPDAGAGVAVM	ECI1	46	P42126
AGTGEVEVVIQDPMG	FLNA	411	P21333
IIIVGVGPAMFEAME	CPNE9	456	Q8IYJ1
IFIVTMEDDFPGGVI	FAT3	3556	Q8TDW7
EITLIIFGVMAGVIG	GYPA	91	P02724
APVVDEAGVILGMVT	CBS	446	P35520
GMELVSVVLGFAVPF	ACKR3	211	P25106
GLEAESVPMAVIIGV	KIRREL3	526	Q8IZU9
SVPMAVIIGVAVGAG	KIRREL3	531	Q8IZU9
IGRFVIEEVPGELMQ	GSN	676	P06396
VQEPGLVMIFAHGVE	RNF41	301	Q9H4P4
MVEPLAGVFGAFAVV	SLC39A11	271	Q8N1S5
IIIVGVGPAEFDAMV	CPNE8	466	Q86YQ8
LPMSIIIVGVGQAEF	CPNE5	481	Q9HCH3
LPMSVIIVGVGGADF	CPNE1	441	Q99829
VGMITVAELAGFVIP	P2RY10	196	O00398
QEDEVPVVGIMATGG	PLA2G4D	316	Q86XP0
VALGDVPDGTVVTVM	RUNX3	96	Q13761
PGISETAMIFAGVDV	SDHA	381	P31040
LIEVFVDGQSVMVEP	NDUFS1	31	P28331
VPLFVDGALVEAGME	SORCS3	651	Q9UPU3
VVDLFPGTFEVVEMV	HEPH	1021	Q9BQS7
LAMAGPEFVEVIGGL	SPG7	371	Q9UQ90
AFMVEPIQGEAGVVV	OAT	226	P04181
AMETNIIPLGEVVGE	CILP	581	O75339
GLIQVMIVVFGDEPP	TSG101	126	Q99816
IFGIEFVGPVVTMTL	PROKR1	236	Q8TCW9
EMAGPGVIVSFIIAA	SLC7A14	81	Q8TBB6
PDAIIVIGEGAQMGI	WNT7B	56	P56706
FIMPDSAVVGDVLVL	SEPHS2	236	Q99611
PGALGVNLVVEEMET	STKLD1	36	Q8NE28
LPIVMGQEEGSVVVE	SYBU	471	Q9NX95
EEVAVPPGLVGYVMV	RNASEH2C	71	Q8TDP1
IAVPKGEAGEMELFV	XDH	751	P47989
RAEGIPVEMVVIGDD	TKFC	126	Q3LXA3
IVEQMVAFIGAVPGI	VMP1	316	Q96GC9
ADMEVIVGDFGIVVV	NMNAT2	216	Q9BZQ4